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Rishi K. Jain, Ph.D. - Publications

Affiliations: 
2002 Yale University, New Haven, CT 
Area:
chemical biology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang AC, Pham HT, Lipps JM, Brittain SM, Harrington E, Wang Y, King FJ, Russ C, Pan X, Hoepfner D, Tallarico J, Feng Y, Jain RK, Schirle M, Thomas JR. Previously uncharacterized v-ATPase binding site discovered from structurally similar compounds with distinct mechanisms of action. Acs Chemical Biology. PMID 30461263 DOI: 10.1021/Acschembio.8B00656  0.316
2017 Thomas JR, Brittain SM, Lipps J, Llamas L, Jain RK, Schirle M. A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates. Methods in Molecular Biology (Clifton, N.J.). 1647: 1-18. PMID 28808992 DOI: 10.1007/978-1-4939-7201-2_1  0.37
2016 Wong ML, Murphy J, Harrington E, Gower CM, Jain RK, Schirle M, Thomas JR. Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors. Proteome Science. 15: 17. PMID 28725163 DOI: 10.1186/S12953-017-0125-1  0.321
2016 Gower CM, Thomas JR, Harrington E, Murphy J, Chang ME, Cornella-Taracido I, Jain RK, Schirle M, Maly DJ. Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity. Acs Chemical Biology. 11: 121-31. PMID 26505072 DOI: 10.1021/Acschembio.5B00847  0.577
2015 Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. Elife. 4. PMID 26651998 DOI: 10.7554/Elife.10222  0.34
2014 Bassilana F, Carlson A, DaSilva JA, Grosshans B, Vidal S, Beck V, Wilmeringwetter B, Llamas LA, Showalter TB, Rigollier P, Bourret A, Ramamurthy A, Wu X, Harbinski F, Plonsky S, ... ... Jain RK, et al. Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nature Chemical Biology. 10: 343-9. PMID 24633354 DOI: 10.1038/Nchembio.1481  0.306
2009 Jain RK, Tsou LK, Hamilton AD. Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates. Tetrahedron Letters. 50: 2787-2789. PMID 20352130 DOI: 10.1016/J.Tetlet.2009.03.153  0.663
2009 Miller-Moslin K, Peukert S, Jain RK, McEwan MA, Karki R, Llamas L, Yusuff N, He F, Li Y, Sun Y, Dai M, Perez L, Michael W, Sheng T, Lei H, et al. 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. Journal of Medicinal Chemistry. 52: 3954-68. PMID 19469545 DOI: 10.1021/Jm900309J  0.358
2009 Peukert S, Jain RK, Geisser A, Sun Y, Zhang R, Bourret A, Carlson A, Dasilva J, Ramamurthy A, Kelleher JF. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorganic & Medicinal Chemistry Letters. 19: 328-31. PMID 19091559 DOI: 10.1016/J.Bmcl.2008.11.096  0.364
2009 Jecklin MC, Touboul D, Jain R, Toole EN, Tallarico J, Drueckes P, Ramage P, Zenobi R. Affinity classification of kinase inhibitors by mass spectrometric methods and validation using standard IC50 measurements Analytical Chemistry. 81: 408-419. PMID 19067573 DOI: 10.1021/Ac801782C  0.363
2006 Zhou H, Wang DA, Baldini L, Ennis E, Jain R, Carie A, Sebti SM, Hamilton AD. Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Organic & Biomolecular Chemistry. 4: 2376-86. PMID 16763682 DOI: 10.1039/B515483A  0.505
2005 Wood WJ, Patterson AW, Tsuruoka H, Jain RK, Ellman JA. Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors. Journal of the American Chemical Society. 127: 15521-7. PMID 16262416 DOI: 10.1021/Ja0547230  0.696
2005 Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 24: 4701-9. PMID 15897913 DOI: 10.1038/Sj.Onc.1208391  0.512
2005 Jain RK, Tsou LK, Hamilton AD. Recognition of cytochrome C by tetraphenylporphyrin-based protein surface receptors Macrocyclic Chemistry: Current Trends and Future Perspectives. 267-275. DOI: 10.1007/1-4020-3687-6_17  0.682
2004 Jain R, Ernst JT, Kutzki O, Park HS, Hamilton AD. Protein recognition using synthetic surface-targeted agents. Molecular Diversity. 8: 89-100. PMID 15209160 DOI: 10.1023/B:Modi.0000025652.55320.16  0.711
2004 Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Research. 64: 3586-92. PMID 15150116 DOI: 10.1158/0008-5472.Can-03-2673  0.668
2004 Tsou LK, Jain RK, Hamilton AD. Protein surface recognition by porphyrin-based receptors Journal of Porphyrins and Phthalocyanines. 8: 141-147. DOI: 10.1142/S1088424604000131  0.717
2003 Jain RK, Trias J, Ellman JA. D-Ala-D-lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant enterococci. Journal of the American Chemical Society. 125: 8740-1. PMID 12862465 DOI: 10.1021/Ja0359761  0.49
2003 Wilson AJ, Groves K, Jain RK, Park HS, Hamilton AD. Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer. Journal of the American Chemical Society. 125: 4420-1. PMID 12683802 DOI: 10.1021/Ja028574M  0.545
2002 Jain RK, Hamilton AD. Designing Protein Denaturants: Synthetic Agents Induce Cytochromec Unfolding at Low Concentrations and Stoichiometries Angewandte Chemie International Edition. 41: 641-643. DOI: 10.1002/1521-3773(20020215)41:4<641::Aid-Anie641>3.0.Co;2-1  0.471
2000 Jain RK, Hamilton AD. Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold. Organic Letters. 2: 1721-3. PMID 10880210 DOI: 10.1021/Ol005871S  0.51
2000 Salvatella X, Peczuh MW, Gairí M, Jain RK, Sánchez-Quesada J, Mendoza Jd, Hamilton AD, Giralt E. Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides Chemical Communications. 1399-1400. DOI: 10.1039/B003728L  0.646
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