| Year |
Citation |
Score |
| 2019 |
Sebti SM, Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31227505 DOI: 10.1158/1078-0432.Ccr-18-3399 |
0.567 |
|
| 2019 |
Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence H, Beato F, Yang Y, Kim MP, Delitto A, Underwood P, Fleming JB, et al. Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3088 |
0.508 |
|
| 2014 |
Aslamuzzaman K, Zhang X, Luo Y, Patel R, Fletcher S, Cummings C, Lawrence H, Hamilton A, Sebti SM. Abstract B35: Dual inhibitors of FT and GGT-1 as novel therapeutic agents for K-Ras-dependent tumors Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B35 |
0.496 |
|
| 2014 |
Zhang W, Zhang D, Stashko MA, DeRyckere D, Hunter D, Kireev D, Miley MJ, Cummings C, Lee M, Norris-Drouin J, Stewart WM, Sather S, Zhou Y, Kirkpatrick G, Machius M, et al. Correction to Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors Journal of Medicinal Chemistry. 57: 7141-7141. DOI: 10.1021/Jm501216S |
0.371 |
|
| 2013 |
Zhang W, Zhang D, Stashko MA, DeRyckere D, Hunter D, Kireev D, Miley MJ, Cummings C, Lee M, Norris-Drouin J, Stewart WM, Sather S, Zhou Y, Kirkpatrick G, Machius M, et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. Journal of Medicinal Chemistry. 56: 9683-92. PMID 24195762 DOI: 10.1021/Jm401387J |
0.418 |
|
| 2013 |
Cummings CG, Hamilton AD. Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics Tetrahedron. 69: 1663-1668. DOI: 10.1016/J.Tet.2012.11.070 |
0.507 |
|
| 2011 |
Kazi A, Luo Y, Berndt N, Fletcher S, Cummings C, Lawrence H, Hamilton AD, Sebti SM. Abstract 620: Development of a dual protein farnesyltransferase -geranylgeranyltransferase-I inhibitor with antitumor activity against human cancer cells Cancer Research. 71: 620-620. DOI: 10.1158/1538-7445.Am2011-620 |
0.614 |
|
| 2010 |
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/Jm1001748 |
0.731 |
|
| 2010 |
Cummings CG, Hamilton AD. Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Current Opinion in Chemical Biology. 14: 341-6. PMID 20430687 DOI: 10.1016/J.Cbpa.2010.04.001 |
0.519 |
|
| 2009 |
Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92. PMID 19246009 DOI: 10.1016/J.Chembiol.2009.01.014 |
0.708 |
|
| 2009 |
Cummings CG, Ross NT, Katt WP, Hamilton AD. Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. Organic Letters. 11: 25-8. PMID 19035840 DOI: 10.1021/Ol8022962 |
0.705 |
|
| 2008 |
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/Jm800113P |
0.803 |
|
| 2006 |
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. Journal of Medicinal Chemistry. 49: 5710-27. PMID 16970397 DOI: 10.1021/Jm060081V |
0.625 |
|
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