| Year |
Citation |
Score |
| 2018 |
Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers NL, Chen MZ, Choi C, Collis LP, Crouse K, F Auml Rneg Aring Rdh M, ... ... Meyers MJ, et al. Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide. A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist. Journal of Medicinal Chemistry. PMID 30130103 DOI: 10.1021/Acs.Jmedchem.8B00392 |
0.326 |
|
| 2014 |
Casimiro-Garcia A, Piotrowski DW, Ambler C, Arhancet GB, Banker ME, Banks T, Boustany-Kari CM, Cai C, Chen X, Eudy R, Hepworth D, Hulford CA, Jennings SM, Loria PM, Meyers MJ, et al. Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist. Journal of Medicinal Chemistry. 57: 4273-88. PMID 24738581 DOI: 10.1021/Jm500206R |
0.354 |
|
| 2010 |
Meyers MJ, Arhancet GB, Hockerman SL, Chen X, Long SA, Mahoney MW, Rico JR, Garland DJ, Blinn JR, Collins JT, Yang S, Huang HC, McGee KF, Wendling JM, Dietz JD, et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. Journal of Medicinal Chemistry. 53: 5979-6002. PMID 20672822 DOI: 10.1021/jm100505n |
0.36 |
|
| 2007 |
Meyers MJ, Hu X. Non-steroidal mineralocorticoid receptor antagonists Expert Opinion On Therapeutic Patents. 17: 17-23. DOI: 10.1517/13543776.17.1.17 |
0.33 |
|
| 2002 |
Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nature Structural Biology. 9: 359-64. PMID 11953755 DOI: 10.1038/Nsb787 |
0.555 |
|
| 2001 |
Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, Katzenellenbogen JA. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. Journal of Medicinal Chemistry. 44: 4230-51. PMID 11708925 DOI: 10.1021/Jm010254A |
0.56 |
|
| 1999 |
Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS. Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β. Endocrinology. 140: 800-804. PMID 28204395 DOI: 10.1210/endo.140.2.6480 |
0.486 |
|
| 1999 |
Meyers MJ, Sun J, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA. Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. Journal of Medicinal Chemistry. 42: 2456-68. PMID 10395487 DOI: 10.1021/Jm990101B |
0.555 |
|
| 1999 |
Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 140: 800-4. PMID 9927308 DOI: 10.1210/Endo.140.2.6480 |
0.568 |
|
| 1998 |
Meyers MJ, Carlson KE, Katzenellenbogen JA. Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters. 8: 3589-94. PMID 9934476 DOI: 10.1016/S0960-894X(98)00652-0 |
0.496 |
|
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