Christian M.T. Spahn, PhD - Publications

Affiliations: 
2015-2016 Institut für Medizinische Physik und Biophysik Charité - Universitätsmedizin Berlin, Germany 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Nikolay R, Hilal T, Qin B, Mielke T, Bürger J, Loerke J, Textoris-Taube K, Nierhaus KH, Spahn CMT. Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution. Molecular Cell. 70: 881-893.e3. PMID 29883607 DOI: 10.1016/j.molcel.2018.05.003  0.64
2015 Yamamoto H, Collier M, Loerke J, Ismer J, Schmidt A, Hilal T, Sprink T, Yamamoto K, Mielke T, Bürger J, Shaikh TR, Dabrowski M, Hildebrand PW, Scheerer P, Spahn CM. Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA. The Embo Journal. PMID 26604301 DOI: 10.15252/embj.201592469  0.52
2015 Kirmizialtin S, Loerke J, Behrmann E, Spahn CM, Sanbonmatsu KY. Using Molecular Simulation to Model High-Resolution Cryo-EM Reconstructions. Methods in Enzymology. 558: 497-514. PMID 26068751 DOI: 10.1016/bs.mie.2015.02.011  0.52
2015 Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM. Structural snapshots of actively translating human ribosomes. Cell. 161: 845-57. PMID 25957688 DOI: 10.1016/j.cell.2015.03.052  0.44
2014 Yamamoto H, Unbehaun A, Loerke J, Behrmann E, Collier M, Bürger J, Mielke T, Spahn CM. Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA. Nature Structural & Molecular Biology. 21: 721-7. PMID 25064512 DOI: 10.1038/nsmb.2859  0.52
2014 Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJ, Mielke T, Ismer J, Hildebrand PW, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CM. Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement. Cell. 158: 121-31. PMID 24995983 DOI: 10.1016/j.cell.2014.04.044  0.64
2014 Penczek PA, Fang J, Li X, Cheng Y, Loerke J, Spahn CM. CTER-rapid estimation of CTF parameters with error assessment. Ultramicroscopy. 140: 9-19. PMID 24562077 DOI: 10.1016/j.ultramic.2014.01.009  0.44
2014 Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, ... ... Spahn CM, et al. A new system for naming ribosomal proteins. Current Opinion in Structural Biology. 24: 165-9. PMID 24524803 DOI: 10.1016/j.sbi.2014.01.002  0.52
2014 Shah C, Hegde BG, Morén B, Behrmann E, Mielke T, Moenke G, Spahn CM, Lundmark R, Daumke O, Langen R. Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure (London, England : 1993). 22: 409-20. PMID 24508342 DOI: 10.1016/j.str.2013.12.015  0.52
2014 Yamamoto H, Qin Y, Achenbach J, Li C, Kijek J, Spahn CM, Nierhaus KH. EF-G and EF4: translocation and back-translocation on the bacterial ribosome. Nature Reviews. Microbiology. 12: 89-100. PMID 24362468 DOI: 10.1038/nrmicro3176  0.64
2012 Ramrath DJ, Yamamoto H, Rother K, Wittek D, Pech M, Mielke T, Loerke J, Scheerer P, Ivanov P, Teraoka Y, Shpanchenko O, Nierhaus KH, Spahn CM. The complex of tmRNA-SmpB and EF-G on translocating ribosomes. Nature. 485: 526-9. PMID 22622583 DOI: 10.1038/nature11006  0.64
2011 Whitford PC, Ahmed A, Yu Y, Hennelly SP, Tama F, Spahn CM, Onuchic JN, Sanbonmatsu KY. Excited states of ribosome translocation revealed through integrative molecular modeling. Proceedings of the National Academy of Sciences of the United States of America. 108: 18943-8. PMID 22080606 DOI: 10.1073/pnas.1108363108  0.52
2011 Penczek PA, Kimmel M, Spahn CM. Identifying conformational states of macromolecules by eigen-analysis of resampled cryo-EM images. Structure (London, England : 1993). 19: 1582-90. PMID 22078558 DOI: 10.1016/j.str.2011.10.003  0.52
2011 Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex. Molecular Cell. 44: 214-24. PMID 22017870 DOI: 10.1016/j.molcel.2011.07.040  0.52
2011 Muhs M, Yamamoto H, Ismer J, Takaku H, Nashimoto M, Uchiumi T, Nakashima N, Mielke T, Hildebrand PW, Nierhaus KH, Spahn CM. Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Research. 39: 5264-75. PMID 21378123 DOI: 10.1093/nar/gkr114  0.64
2010 Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, ... ... Spahn CM, et al. Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature. 468: 713-6. PMID 21124459 DOI: 10.1038/nature09547  0.52
2009 Spahn CM, Penczek PA. Exploring conformational modes of macromolecular assemblies by multiparticle cryo-EM. Current Opinion in Structural Biology. 19: 623-31. PMID 19767196 DOI: 10.1016/j.sbi.2009.08.001  0.44
2009 Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome's metastable energy landscape. Trends in Biochemical Sciences. 34: 390-400. PMID 19647434 DOI: 10.1016/j.tibs.2009.04.004  0.52
2009 Schuette JC, Murphy FV, Kelley AC, Weir JR, Giesebrecht J, Connell SR, Loerke J, Mielke T, Zhang W, Penczek PA, Ramakrishnan V, Spahn CM. GTPase activation of elongation factor EF-Tu by the ribosome during decoding. The Embo Journal. 28: 755-65. PMID 19229291 DOI: 10.1038/emboj.2009.26  0.52
2008 Connell SR, Topf M, Qin Y, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM. A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology. 15: 910-5. PMID 19172743  0.64
2008 Zhang W, Kimmel M, Spahn CM, Penczek PA. Heterogeneity of large macromolecular complexes revealed by 3D cryo-EM variance analysis. Structure (London, England : 1993). 16: 1770-6. PMID 19081053 DOI: 10.1016/j.str.2008.10.011  0.52
2008 Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. A dose-rate effect in single-particle electron microscopy. Journal of Structural Biology. 161: 92-100. PMID 17977018 DOI: 10.1016/j.jsb.2007.09.017  0.52
2006 Schüler M, Connell SR, Lescoute A, Giesebrecht J, Dabrowski M, Schroeer B, Mielke T, Penczek PA, Westhof E, Spahn CM. Structure of the ribosome-bound cricket paralysis virus IRES RNA. Nature Structural & Molecular Biology. 13: 1092-6. PMID 17115051 DOI: 10.1038/nsmb1177  0.44
2006 Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R. Structure of eEF3 and the mechanism of transfer RNA release from the E-site. Nature. 443: 663-8. PMID 16929303 DOI: 10.1038/nature05126  0.52
2006 Hofmann KP, Spahn CM, Heinrich R, Heinemann U. Building functional modules from molecular interactions. Trends in Biochemical Sciences. 31: 497-508. PMID 16890441 DOI: 10.1016/j.tibs.2006.07.006  0.52
2006 Penczek PA, Frank J, Spahn CM. A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation. Journal of Structural Biology. 154: 184-94. PMID 16520062 DOI: 10.1016/j.jsb.2005.12.013  0.52
2006 Penczek PA, Yang C, Frank J, Spahn CM. Estimation of variance in single-particle reconstruction using the bootstrap technique. Journal of Structural Biology. 154: 168-83. PMID 16510296 DOI: 10.1016/j.jsb.2006.01.003  0.52
2005 Halic M, Becker T, Frank J, Spahn CM, Beckmann R. Localization and dynamic behavior of ribosomal protein L30e. Nature Structural & Molecular Biology. 12: 467-8. PMID 15864315 DOI: 10.1038/nsmb933  0.92
2004 Sengupta J, Nilsson J, Gursky R, Spahn CM, Nissen P, Frank J. Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nature Structural & Molecular Biology. 11: 957-62. PMID 15334071 DOI: 10.1038/nsmb822  0.92
2004 Spahn CM, Jan E, Mulder A, Grassucci RA, Sarnow P, Frank J. Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell. 118: 465-75. PMID 15315759 DOI: 10.1016/j.cell.2004.08.001  0.52
2004 Agrawal RK, Sharma MR, Kiel MC, Hirokawa G, Booth TM, Spahn CM, Grassucci RA, Kaji A, Frank J. Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proceedings of the National Academy of Sciences of the United States of America. 101: 8900-5. PMID 15178758 DOI: 10.1073/pnas.0401904101  0.92
2004 Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R. Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature. 427: 808-14. PMID 14985753 DOI: 10.1038/nature02342  0.52
2004 Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jørgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J. Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. The Embo Journal. 23: 1008-19. PMID 14976550 DOI: 10.1038/sj.emboj.7600102  0.92
2003 Moccia R, Chen D, Lyles V, Kapuya E, E Y, Kalachikov S, Spahn CM, Frank J, Kandel ER, Barad M, Martin KC. An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9409-17. PMID 14561869  0.52
2002 Gao H, Spahn CM, Grassucci RA, Frank J. An assay for local quality in cryo-electron micrographs of single particles. Ultramicroscopy. 93: 169-78. PMID 12425594  0.92
2002 Schäfer MA, Tastan AO, Patzke S, Blaha G, Spahn CM, Wilson DN, Nierhaus KH. Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit. The Journal of Biological Chemistry. 277: 19095-105. PMID 11867615 DOI: 10.1074/jbc.M108902200  0.64
2001 Beckmann R, Spahn CM, Frank J, Blobel G. The active 80S ribosome-Sec61 complex. Cold Spring Harbor Symposia On Quantitative Biology. 66: 543-54. PMID 12762056  0.52
2001 Spahn CM, Beckmann R, Eswar N, Penczek PA, Sali A, Blobel G, Frank J. Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell. 107: 373-86. PMID 11701127 DOI: 10.1016/S0092-8674(01)00539-6  0.52
2001 Beckmann R, Spahn CM, Eswar N, Helmers J, Penczek PA, Sali A, Frank J, Blobel G. Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell. 107: 361-72. PMID 11701126 DOI: 10.1016/S0092-8674(01)00541-4  0.52
2001 Spahn CM, Blaha G, Agrawal RK, Penczek P, Grassucci RA, Trieber CA, Connell SR, Taylor DE, Nierhaus KH, Frank J. Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance. Molecular Cell. 7: 1037-45. PMID 11389850  0.92
2001 Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science (New York, N.Y.). 291: 1959-62. PMID 11239155 DOI: 10.1126/science.1058409  0.52
2000 Diedrich G, Spahn CM, Stelzl U, Schäfer MA, Wooten T, Bochkariov DE, Cooperman BS, Traut RR, Nierhaus KH. Ribosomal protein L2 is involved in the association of the ribosomal subunits, tRNA binding to A and P sites and peptidyl transfer. The Embo Journal. 19: 5241-50. PMID 11013226 DOI: 10.1093/emboj/19.19.5241  0.52
2000 Spahn CM, Penczek PA, Leith A, Frank J. A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome. Structure (London, England : 1993). 8: 937-48. PMID 10986461  0.92
2000 Agrawal RK, Spahn CM, Penczek P, Grassucci RA, Nierhaus KH, Frank J. Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle. The Journal of Cell Biology. 150: 447-60. PMID 10931859  0.92
2000 Stelzl U, Spahn CM, Nierhaus KH. RNA-protein interactions in ribosomes: in vitro selection from randomly fragmented rRNA. Methods in Enzymology. 318: 251-68. PMID 10889993  0.64
2000 Gomez-Lorenzo MG, Spahn CM, Agrawal RK, Grassucci RA, Penczek P, Chakraburtty K, Ballesta JP, Lavandera JL, Garcia-Bustos JF, Frank J. Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution. The Embo Journal. 19: 2710-8. PMID 10835368 DOI: 10.1093/emboj/19.11.2710  0.92
2000 Blaha G, Stelzl U, Spahn CM, Agrawal RK, Frank J, Nierhaus KH. Preparation of functional ribosomal complexes and effect of buffer conditions on tRNA positions observed by cryoelectron microscopy. Methods in Enzymology. 317: 292-309. PMID 10829287  0.92
2000 Triana-Alonso FJ, Spahn CM, Burkhardt N, Röhrdanz B, Nierhaus KH. Experimental prerequisites for determination of tRNA binding to ribosomes from Escherichia coli. Methods in Enzymology. 317: 261-76. PMID 10829285  0.64
2000 Stelzl U, Spahn CM, Nierhaus KH. Selecting rRNA binding sites for the ribosomal proteins L4 and L6 from randomly fragmented rRNA: application of a method called SERF. Proceedings of the National Academy of Sciences of the United States of America. 97: 4597-602. PMID 10781065 DOI: 10.1073/pnas.090009297  0.64
2000 Gabashvili IS, Agrawal RK, Spahn CM, Grassucci RA, Svergun DI, Frank J, Penczek P. Solution structure of the E. coli 70S ribosome at 11.5 A resolution. Cell. 100: 537-49. PMID 10721991  0.92
1999 Spahn CM, Grassucci RA, Penczek P, Frank J. Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cryo-electron microscopy. Structure (London, England : 1993). 7: 1567-73. PMID 10647187  0.92
1998 Dabrowski M, Spahn CM, Schäfer MA, Patzke S, Nierhaus KH. Protection patterns of tRNAs do not change during ribosomal translocation. The Journal of Biological Chemistry. 273: 32793-800. PMID 9830024  0.64
1998 Spahn CM, Nierhaus KH. Models of the elongation cycle: an evaluation. Biological Chemistry. 379: 753-72. PMID 9705140  0.64
1998 Burkhardt N, Jünemann R, Spahn CM, Nierhaus KH. Ribosomal tRNA binding sites: three-site models of translation. Critical Reviews in Biochemistry and Molecular Biology. 33: 95-149. PMID 9598294 DOI: 10.1080/10409239891204189  0.64
1998 Saarma U, Spahn CM, Nierhaus KH, Remme J. Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center. Rna (New York, N.Y.). 4: 189-94. PMID 9570318  0.64
1997 Nierhaus KH, Jünemann R, Spahn CM. Are the current three-site models valid descriptions of the ribosomal elongation cycle? Proceedings of the National Academy of Sciences of the United States of America. 94: 10499-500. PMID 9380668  0.64
1996 Dabrowski M, Junemann R, Schafer MA, Spahn CM, Nierhaus KH, Alekseeva EV, Dontsova OA, Shpanchenko OV, Bogdanov AA. [Phosphate sites of RNA-ligands interacting with ribosome at different stages of translation. Thiophosphate method of analysis]. BiokhimiiÍ¡a (Moscow, Russia). 61: 1971-83. PMID 9004858  0.64
1996 Spahn CM, Schäfer MA, Krayevsky AA, Nierhaus KH. Conserved nucleotides of 23 S rRNA located at the ribosomal peptidyltransferase center. The Journal of Biological Chemistry. 271: 32857-62. PMID 8955124  0.64
1996 Spahn CM, Remme J, Schäfer MA, Nierhaus KH. Mutational analysis of two highly conserved UGG sequences of 23 S rRNA from Escherichia coli. The Journal of Biological Chemistry. 271: 32849-56. PMID 8955123  0.64
1996 Meyer HA, Triana-Alonso F, Spahn CM, Twardowski T, Sobkiewicz A, Nierhaus KH. Effects of antisense DNA against the alpha-sarcin stem-loop structure of the ribosomal 23S rRNA. Nucleic Acids Research. 24: 3996-4002. PMID 8918803  0.64
1996 Spahn CM, Prescott CD. Throwing a spanner in the works: antibiotics and the translation apparatus. Journal of Molecular Medicine (Berlin, Germany). 74: 423-39. PMID 8872856  0.52
1995 Nierhaus KH, Beyer D, Dabrowski M, Schäfer MA, Spahn CM, Wadzack J, Bittner JU, Burkhardt N, Diedrich G, Jünemann R. The elongating ribosome: structural and functional aspects. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 73: 1011-21. PMID 8722016  0.64
1995 Dabrowski M, Spahn CM, Nierhaus KH. Interaction of tRNAs with the ribosome at the A and P sites. The Embo Journal. 14: 4872-82. PMID 7588616  0.64
1990 Kutay UR, Spahn CM, Nierhaus KH. Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA. Biochimica Et Biophysica Acta. 1050: 193-6. PMID 2169893 DOI: 10.1016/0167-4781(90)90165-X  0.52
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