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Diego Acosta-Alvear, Ph.D. - Publications

Affiliations: 
2008 Basic Medical Science New York University, New York, NY, United States 
Area:
Mammalian Transcription
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, et al. Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nature Communications. 11: 2401. PMID 32409639 DOI: 10.1038/S41467-020-15694-Y  0.385
2020 Solley S, Zappa F, Acosta-Alvear D. Regulation of the mammalian cell cycle by the unfolded protein response The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08710  0.437
2019 Karagöz GE, Aragón T, Acosta-Alvear D. Recent advances in signal integration mechanisms in the unfolded protein response. F1000research. 8. PMID 31723416 DOI: 10.12688/F1000Research.19848.1  0.376
2019 Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, ... ... Acosta-Alvear D, et al. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. PMID 31371506 DOI: 10.1073/Pnas.1906999116  0.396
2019 Karagöz GE, Acosta-Alvear D, Walter P. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harbor Perspectives in Biology. PMID 30670466 DOI: 10.1101/Cshperspect.A033886  0.362
2018 Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 7. PMID 30582518 DOI: 10.7554/Elife.43036  0.357
2018 Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. Author response: The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1 Elife. DOI: 10.7554/Elife.43036.025  0.353
2017 Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 6. PMID 28971800 DOI: 10.7554/Elife.30700  0.342
2017 Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137856 DOI: 10.1073/Pnas.1621188114  0.354
2017 Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. Author response: An unfolded protein-induced conformational switch activates mammalian IRE1 Elife. DOI: 10.7554/Elife.30700.034  0.305
2017 Ramkumar P, Tawney J, Acosta-Alvear D, Kampmann M. Abstract A30: Identifying microenvironment-dependent vulnerabilities in multiple myeloma using CRISPRi Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A30  0.427
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4. PMID 25986605 DOI: 10.7554/Elife.05434  0.326
2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the hsp70-bag3 protein-protein interaction as a potential therapeutic target in cancer. Molecular Cancer Therapeutics. 14: 642-8. PMID 25564440 DOI: 10.1158/1535-7163.Mct-14-0650  0.405
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Elife. DOI: 10.7554/Elife.05434.022  0.336
2015 Acosta-Alvear D, Kampmann M, Cho MY, Wild T, Choudhary C, Shuman MA, Weissman JS, Walter P. Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A43  0.453
2015 Acosta-Alvear D, Kampmann M, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-57  0.421
2015 Kampmann M, Acosta-Alvear D, Gilbert LA, Horlbeck MA, Cho MY, Adamson B, Villalta J, Chen Y, Walter P, Weissman JS. Abstract A2-56: Cancer-specific synthetic lethality and network rewiring elucidated by genetic interaction maps and CRISPR-based gain- and loss-of-function screens Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-56  0.439
2015 Cho MY, Acosta-Alvear D, Kampmann M, Wild T, Choudhary CR, Weissman JS, Walter P. Abstract A2-12: Opposing roles of the 19S regulatory and 20S core proteasomal subunits in controlling sensitivity to proteasome inhibitors Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-12  0.454
2014 Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Cell death. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science (New York, N.Y.). 345: 98-101. PMID 24994655 DOI: 10.1126/Science.1254312  0.373
2013 Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2: e00498. PMID 23741617 DOI: 10.7554/Elife.00498  0.354
2013 Kampmann M, Acosta-Alvear D, Cho M, Chen Y, Li X, Gilbert L, Aftab BT, Gestwicki J, Walter P, Weissman JS. Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Pr07  0.443
2013 Acosta-Alvear D, Kampmann M, Bassik MC, Lee CP, Cho MY, Aftab BT, Li X, Gestwicki JE, Shuman MA, Weissman JS, Walter P. Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C01  0.463
2013 Kampmann M, Acosta-Alvear D, Bassik MC, Chen Y, Walter P, Weissman JS. Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr06  0.428
2013 Acosta-Alvear D, Kampmann M, Bassik MC, Lee CP, Shuman MA, Weissman JS, Walter P. Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A08  0.476
2011 Behrman S, Acosta-Alvear D, Walter P. A CHOP-regulated microRNA controls rhodopsin expression. The Journal of Cell Biology. 192: 919-27. PMID 21402790 DOI: 10.1083/Jcb.201010055  0.332
2010 Tsikitis M, Acosta-Alvear D, Blais A, Campos EI, Lane WS, Sánchez I, Dynlacht BD. Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis. Embo Reports. 11: 969-76. PMID 20948544 DOI: 10.1038/Embor.2010.154  0.573
2010 Acosta-Alvear D, Hann BC, Rabinovich BA, Shuman MA, Walter P. Multi-Modality Imaging of Multiple Myeloma Bone Disease In Orthotopic Xenograft Models Blood. 116: 5014-5014. DOI: 10.1182/Blood.V116.21.5014.5014  0.309
2009 Asp P, Acosta-Alvear D, Tsikitis M, van Oevelen C, Dynlacht BD. E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes & Development. 23: 37-53. PMID 19136625 DOI: 10.1101/Gad.1727309  0.628
2007 Blais A, van Oevelen CJ, Margueron R, Acosta-Alvear D, Dynlacht BD. Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. The Journal of Cell Biology. 179: 1399-412. PMID 18166651 DOI: 10.1083/Jcb.200705051  0.602
2007 Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Molecular Cell. 27: 53-66. PMID 17612490 DOI: 10.1016/J.Molcel.2007.06.011  0.633
2005 Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BD. An initial blueprint for myogenic differentiation. Genes & Development. 19: 553-69. PMID 15706034 DOI: 10.1101/Gad.1281105  0.607
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