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Ryan A. Mehl, Ph.D. - Publications

Affiliations: 
2001 Cornell University, Ithaca, NY, United States 
Area:
Barton Professor of Chemistry
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Eddins AJ, Bednar RM, Jana S, Pung AH, Mbengi L, Meyer K, Perona JJ, Cooley RB, Karplus PA, Mehl RA. Truncation-Free Genetic Code Expansion with Tetrazine Amino Acids for Quantitative Protein Ligations. Bioconjugate Chemistry. PMID 38047550 DOI: 10.1021/acs.bioconjchem.3c00380  0.371
2023 Bednar RM, Karplus PA, Mehl RA. Site-specific dual encoding and labeling of proteins via genetic code expansion. Cell Chemical Biology. PMID 36977415 DOI: 10.1016/j.chembiol.2023.03.004  0.34
2023 Galles GD, Infield DT, Clark CJ, Hemshorn ML, Manikandan S, Fazan F, Rasouli A, Tajkhorshid E, Galpin JD, Cooley RB, Mehl RA, Ahern CA. Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells. Nature Communications. 14: 59. PMID 36599844 DOI: 10.1038/s41467-022-35761-w  0.335
2021 Zhu P, Franklin R, Vogel A, Stanisheuski S, Reardon P, Sluchanko NN, Beckman JS, Karplus PA, Mehl RA, Cooley RB. PermaPhos : autonomous synthesis of functional, permanently phosphorylated proteins. Biorxiv : the Preprint Server For Biology. PMID 34931187 DOI: 10.1101/2021.10.22.465468  0.349
2021 Bednar RM, Jana S, Kuppa S, Franklin R, Beckman J, Antony E, Cooley RB, Mehl RA. Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells. Acs Chemical Biology. PMID 34590824 DOI: 10.1021/acschembio.1c00649  0.376
2021 Galles GD, Infield DT, Mehl RA, Ahern CA. Selection and validation of orthogonal tRNA/synthetase pairs for the encoding of unnatural amino acids across kingdoms. Methods in Enzymology. 654: 3-18. PMID 34120719 DOI: 10.1016/bs.mie.2021.03.009  0.333
2020 Jang HS, Gu X, Cooley RB, Porter JJ, Henson RL, Willi T, DiDonato JA, Hazen SL, Mehl RA. Correction to Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins. Acs Chemical Biology. PMID 33382237 DOI: 10.1021/acschembio.0c00951  0.376
2020 Oscar BG, Zhu L, Wolfendeen H, Rozanov ND, Chang A, Stout KT, Sandwisch JW, Porter JJ, Mehl RA, Fang C. Dissecting Optical Response and Molecular Structure of Fluorescent Proteins With Non-canonical Chromophores. Frontiers in Molecular Biosciences. 7: 131. PMID 32733917 DOI: 10.3389/Fmolb.2020.00131  0.315
2020 Beyer J, Hosseinzadeh P, Gottfried-Lee I, Van Fossen EM, Zhu P, Bednar RM, Karplus PA, Mehl RA, Cooley RB. Overcoming near-cognate suppression in a Release Factor 1-deficient host with an improved nitro-tyrosine tRNA synthetase. Journal of Molecular Biology. PMID 32569745 DOI: 10.1016/J.Jmb.2020.06.014  0.435
2020 Jang HS, Jana S, Blizzard RJ, Meeuwsen JC, Mehl RA. Access To Faster Eukaryotic Cell Labeling With Encoded Tetrazine Amino Acids. Journal of the American Chemical Society. PMID 32251579 DOI: 10.1021/Jacs.9B11520  0.465
2020 Jang HS, Gu X, Cooley RB, Porter JJ, Henson RL, Willi T, DiDonato JA, Hazen SL, Mehl RA. Efficient site-specific prokaryotic and eukaryotic incorporation of halotyrosine amino acids into proteins. Acs Chemical Biology. PMID 31994864 DOI: 10.1021/Acschembio.9B01026  0.411
2019 Bednar R, Golbek TW, Kean KM, Brown WJ, Jana S, Baio JE, Karplus PA, Mehl RA. Immobilization of Proteins with Controlled Load and Orientation. Acs Applied Materials & Interfaces. PMID 31525993 DOI: 10.1021/Acsami.9B12746  0.369
2019 Zhu P, Gafken PR, Mehl RA, Cooley RB. A Highly Versatile Expression System for the Production of Multiply Phosphorylated Proteins. Acs Chemical Biology. PMID 31243963 DOI: 10.1021/Acschembio.9B00307  0.323
2019 Porter JJ, Jang HS, Van Fossen EM, Nguyen DP, Willi TS, Cooley RB, Mehl RA. Genetically encoded protein tyrosine nitration in mammalian cells. Acs Chemical Biology. PMID 31117397 DOI: 10.1021/Acschembio.9B00371  0.372
2019 Petersson EJ, Mehl RA, Ahern CA. Expanding Genetic Code Expansion through Resource Facilities, Workshops, and Conferences. International Journal of Molecular Sciences. 20. PMID 31035437 DOI: 10.3390/Ijms20092103  0.313
2019 Fick RJ, Horowitz S, McDole BG, Clay MC, Mehl RA, Al-Hashimi HM, Scheiner S, Trievel RC. Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. Biochemistry. PMID 30810306 DOI: 10.1021/Acs.Biochem.8B01141  0.305
2018 Muzika M, Muskat NH, Sarid S, Ben-David O, Mehl RA, Arbely E. Chemically-defined lactose-based autoinduction medium for site-specific incorporation of non-canonical amino acids into proteins. Rsc Advances. 8: 25558-25567. PMID 30713681 DOI: 10.1039/C8Ra04359K  0.453
2018 Porter JJ, Mehl RA. Genetic Code Expansion: A Powerful Tool for Understanding the Physiological Consequences of Oxidative Stress Protein Modifications. Oxidative Medicine and Cellular Longevity. 2018: 7607463. PMID 29849913 DOI: 10.1155/2018/7607463  0.353
2018 Blizzard RJ, Gibson TE, Mehl RA. Site-Specific Protein Labeling with Tetrazine Amino Acids. Methods in Molecular Biology (Clifton, N.J.). 1728: 201-217. PMID 29405000 DOI: 10.1007/978-1-4939-7574-7_13  0.469
2018 Kean KM, van Zee K, Mehl RA. Unnatural Chemical Biology: Research-Based Laboratory Course Utilizing Genetic Code Expansion Journal of Chemical Education. 96: 66-74. DOI: 10.1021/Acs.Jchemed.8B00011  0.383
2017 Pokhrel N, Origanti S, Davenport EP, Gandhi D, Kaniecki K, Mehl RA, Greene EC, Dockendorff C, Antony E. Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids. Nucleic Acids Research. 45: 9413-9426. PMID 28934470 DOI: 10.1093/Nar/Gkx598  0.353
2017 Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28848969 DOI: 10.1039/C7Ob90144E  0.505
2017 Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28752889 DOI: 10.1039/C7Ob01707C  0.581
2017 Row RD, Shih HW, Alexander AT, Mehl RA, Prescher JA. Cyclopropenones for metabolic targeting and sequential bioorthogonal labeling. Journal of the American Chemical Society. PMID 28478678 DOI: 10.1021/Jacs.7B03010  0.365
2017 Sungwienwong I, Hostetler ZM, Blizzard RJ, Porter JJ, Driggers CM, Mbengi LZ, Villegas JA, Speight LC, Saven JG, Perona JJ, Kohli RM, Mehl RA, Petersson EJ. Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection. Organic & Biomolecular Chemistry. PMID 28397914 DOI: 10.1039/C7Ob00582B  0.418
2017 Scholfield MR, Ford MC, Carlsson AC, Butta H, Mehl RA, Ho PS. Structure-Energy Relationships of Halogen Bonds in Proteins. Biochemistry. PMID 28345933 DOI: 10.1021/Acs.Biochem.7B00022  0.312
2016 Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL. A systematic investigation of structure/function requirements for the apolipoprotein A-I - lecithin cholesterol acyltransferase interaction loop of HDL. The Journal of Biological Chemistry. PMID 26797122 DOI: 10.1074/Jbc.M115.696088  0.311
2015 Rauch BJ, Porter JJ, Mehl RA, Perona JJ. Improved incorporation of noncanonical amino acids by an engineered tRNATyr suppressor. Biochemistry. PMID 26694948 DOI: 10.1021/Acs.Biochem.5B01185  0.429
2015 Leisle L, Valiyaveetil F, Mehl RA, Ahern CA. Incorporation of Non-Canonical Amino Acids. Advances in Experimental Medicine and Biology. 869: 119-51. PMID 26381943 DOI: 10.1007/978-1-4939-2845-3_7  0.411
2015 Blizzard RJ, Backus DR, Brown W, Bazewicz CG, Li YI, Mehl RA. Ideal Bioorthogonal Reactions Using A Site-Specifically Encoded Tetrazine Amino Acid. Journal of the American Chemical Society. PMID 26237426 DOI: 10.1021/Jacs.5B03275  0.428
2015 Kamber DN, Liang Y, Blizzard RJ, Liu F, Mehl RA, Houk KN, Prescher JA. 1,2,4-Triazines Are Versatile Bioorthogonal Reagents. Journal of the American Chemical Society. PMID 26084312 DOI: 10.1021/Jacs.5B05100  0.332
2014 Darko A, Wallace S, Dmitrenko O, Machovina MM, Mehl RA, Chin JW, Fox JM. Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. Chemical Science. 5: 3770-3776. PMID 26113970 DOI: 10.1039/C4Sc01348D  0.547
2014 Cooley RB, Karplus PA, Mehl RA. Gleaning unexpected fruits from hard-won synthetases: probing principles of permissivity in non-canonical amino acid-tRNA synthetases. Chembiochem : a European Journal of Chemical Biology. 15: 1810-9. PMID 25044993 DOI: 10.1002/Cbic.201402180  0.405
2014 Horowitz S, Adhikari U, Dirk LM, Del Rizzo PA, Mehl RA, Houtz RL, Al-Hashimi HM, Scheiner S, Trievel RC. Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. Acs Chemical Biology. 9: 1692-7. PMID 24914947 DOI: 10.1021/Cb5001185  0.308
2014 Wang K, Sachdeva A, Cox DJ, Wilf NM, Wilf NW, Lang K, Wallace S, Mehl RA, Chin JW. Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET. Nature Chemistry. 6: 393-403. PMID 24755590 DOI: 10.1038/Nchem.1919  0.651
2014 Cooley RB, Feldman JL, Driggers CM, Bundy TA, Stokes AL, Karplus PA, Mehl RA. Structural basis of improved second-generation 3-nitro-tyrosine tRNA synthetases. Biochemistry. 53: 1916-24. PMID 24611875 DOI: 10.1021/Bi5001239  0.394
2014 Wang K, Sachdeva A, Cox DJ, Wilf NM, Lang K, Wallace S, Mehl RA, Chin JW. Erratum: Corrigendum: Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET Nature Chemistry. 7: 178-178. DOI: 10.1038/Nchem.2175  0.544
2013 Speight LC, Muthusamy AK, Goldberg JM, Warner JB, Wissner RF, Willi TS, Woodman BF, Mehl RA, Petersson EJ. Efficient synthesis and in vivo incorporation of acridon-2-ylalanine, a fluorescent amino acid for lifetime and Förster resonance energy transfer/luminescence resonance energy transfer studies. Journal of the American Chemical Society. 135: 18806-14. PMID 24303933 DOI: 10.1021/Ja403247J  0.455
2013 Wu IL, Patterson MA, Carpenter Desai HE, Mehl RA, Giorgi G, Conticello VP. Multiple site-selective insertions of noncanonical amino acids into sequence-repetitive polypeptides. Chembiochem : a European Journal of Chemical Biology. 14: 968-78. PMID 23625817 DOI: 10.1002/Cbic.201300069  0.465
2013 Averick SE, Bazewicz CG, Woodman BF, Simakova A, Mehl RA, Matyjaszewski K. Protein-polymer hybrids: Conducting ARGET ATRP from a genetically encoded cleavable ATRP initiator European Polymer Journal. 49: 2919-2924. DOI: 10.1016/J.Eurpolymj.2013.04.015  0.352
2012 Seitchik JL, Peeler JC, Taylor MT, Blackman ML, Rhoads TW, Cooley RB, Refakis C, Fox JM, Mehl RA. Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes. Journal of the American Chemical Society. 134: 2898-901. PMID 22283158 DOI: 10.1021/Ja2109745  0.49
2012 Libby RD, Mehl RA. Characterization of covalent Ene adduct intermediates in "hydride equivalent" transfers in a dihydropyridine model for NADH reduction reactions. Bioorganic Chemistry. 40: 57-66. PMID 22112981 DOI: 10.1016/J.Bioorg.2011.10.002  0.308
2012 Peeler JC, Mehl RA. Site-specific incorporation of unnatural amino acids as probes for protein conformational changes. Methods in Molecular Biology (Clifton, N.J.). 794: 125-34. PMID 21956560 DOI: 10.1007/978-1-61779-331-8_8  0.447
2011 Averick SE, Magenau AJD, Simakova A, Woodman BF, Seong A, Mehl RA, Matyjaszewski K. Covalently incorporated protein-nanogels using AGET ATRP in an inverse miniemulsion Polymer Chemistry. 2: 1476-1478. DOI: 10.1039/C1Py00050K  0.409
2010 Rowe L, Ensor M, Mehl R, Daunert S. Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids. Acs Chemical Biology. 5: 455-60. PMID 20230005 DOI: 10.1021/Cb9002909  0.463
2010 Miyake-Stoner SJ, Refakis CA, Hammill JT, Lusic H, Hazen JL, Deiters A, Mehl RA. Generating permissive site-specific unnatural aminoacyl-tRNA synthetases. Biochemistry. 49: 1667-77. PMID 20082521 DOI: 10.1021/Bi901947R  0.63
2010 Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl RA, Pielak GJ. Protein (19)F NMR in Escherichia coli. Journal of the American Chemical Society. 132: 321-7. PMID 20050707 DOI: 10.1021/Ja907966N  0.381
2009 Stokes AL, Miyake-Stoner SJ, Peeler JC, Nguyen DP, Hammer RP, Mehl RA. Enhancing the utility of unnatural amino acid synthetases by manipulating broad substrate specificity. Molecular Biosystems. 5: 1032-8. PMID 19668869 DOI: 10.1039/B904032C  0.467
2009 Taskent-Sezgin H, Chung J, Patsalo V, Miyake-Stoner SJ, Miller AM, Brewer SH, Mehl RA, Green DF, Raleigh DP, Carrico I. Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study. Biochemistry. 48: 9040-6. PMID 19658436 DOI: 10.1021/Bi900938Z  0.345
2009 Miyake-Stoner SJ, Miller AM, Hammill JT, Peeler JC, Hess KR, Mehl RA, Brewer SH. Probing protein folding using site-specifically encoded unnatural amino acids as FRET donors with tryptophan. Biochemistry. 48: 5953-62. PMID 19492814 DOI: 10.1021/Bi900426D  0.449
2008 Neumann H, Hazen JL, Weinstein J, Mehl RA, Chin JW. Genetically encoding protein oxidative damage. Journal of the American Chemical Society. 130: 4028-33. PMID 18321101 DOI: 10.1021/Ja710100D  0.562
2007 Hammill JT, Miyake-Stoner S, Hazen JL, Jackson JC, Mehl RA. Preparation of site-specifically labeled fluorinated proteins for 19F-NMR structural characterization. Nature Protocols. 2: 2601-7. PMID 17948003 DOI: 10.1038/Nprot.2007.379  0.361
2007 Jackson JC, Hammill JT, Mehl RA. Site-specific incorporation of a (19)F-amino acid into proteins as an NMR probe for characterizing protein structure and reactivity. Journal of the American Chemical Society. 129: 1160-6. PMID 17263397 DOI: 10.1021/Ja064661T  0.41
2006 Jackson JC, Duffy SP, Hess KR, Mehl RA. Improving nature's enzyme active site with genetically encoded unnatural amino acids. Journal of the American Chemical Society. 128: 11124-7. PMID 16925430 DOI: 10.1021/Ja061099Y  0.452
2005 Farrell IS, Toroney R, Hazen JL, Mehl RA, Chin JW. Photo-cross-linking interacting proteins with a genetically encoded benzophenone. Nature Methods. 2: 377-84. PMID 16170867 DOI: 10.1038/Nmeth0505-377  0.541
2004 Lawhorn BG, Mehl RA, Begley TP. Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Organic & Biomolecular Chemistry. 2: 2538-46. PMID 15326535 DOI: 10.1039/B405429F  0.723
2003 Mehl RA, Anderson JC, Santoro SW, Wang L, Martin AB, King DS, Horn DM, Schultz PG. Generation of a bacterium with a 21 amino acid genetic code. Journal of the American Chemical Society. 125: 935-9. PMID 12537491 DOI: 10.1021/Ja0284153  0.714
2002 Mehl RA, Begley TP. Synthesis of 32P-labeled intermediates on the purine biosynthetic pathway Journal of Labelled Compounds and Radiopharmaceuticals. 45: 1097-1102. DOI: 10.1002/Jlcr.627  0.435
2001 Begley TP, Kinsland C, Mehl RA, Osterman A, Dorrestein P. The biosynthesis of nicotinamide adenine dinucleotides in bacteria. Vitamins and Hormones. 61: 103-19. PMID 11153263 DOI: 10.1016/S0083-6729(01)61003-3  0.752
2000 Mehl RA, Kinsland C, Begley TP. Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene. Journal of Bacteriology. 182: 4372-4. PMID 10894752 DOI: 10.1128/Jb.182.15.4372-4374.2000  0.698
1999 Mehl RA, Begley TP. Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct. Organic Letters. 1: 1065-6. PMID 10825958 DOI: 10.1021/Ol9908676  0.434
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