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Tom Huxford, Ph.D. - Publications

Affiliations: 
2005- Chemistry & Biochemistry San Diego State University, San Diego, CA, United States 
Area:
NF-kappaB, Metalloantibodies, Myosin, Signal Transduction, Structural Biochemistry
Website:
http://thuxford.sdsu.edu
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhu N, Mealka M, Mitchel S, Milani C, Acuña LM, Rogers E, Lahana AN, Huxford T. X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA. Biomolecules. 13. PMID 37759710 DOI: 10.3390/biom13091310  0.728
2023 Borar P, Biswas T, Chaudhuri A, Huxford T, Chakrabarti S, Ghosh G, Polley S. Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα without requiring ATP. Biorxiv : the Preprint Server For Biology. PMID 37732175 DOI: 10.1101/2023.06.27.546692  0.618
2022 Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, et al. TWEAK-Fn14-RelB signaling cascade promotes stem cell-like features that contribute to post-chemotherapy ovarian cancer relapse. Molecular Cancer Research : McR. PMID 36214671 DOI: 10.1158/1541-7786.MCR-22-0486  0.734
2022 Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2. The Journal of Biological Chemistry. 298: 101864. PMID 35339487 DOI: 10.1016/j.jbc.2022.101864  0.815
2021 Kour S, Rana S, Kizhake S, Lagundžin D, Klinkebiel D, Mallareddy JR, Huxford T, Woods NT, Natarajan A. Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA. Rsc Chemical Biology. 3: 32-36. PMID 35128406 DOI: 10.1039/d1cb00183c  0.302
2020 Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140526. PMID 32853772 DOI: 10.1016/J.Bbapap.2020.140526  0.801
2020 Farokhi E, Fleming JK, Erasmus MF, Ward AD, Wu Y, Gutierrez MG, Wojciak JM, Huxford T. Ion Binding Properties of a Naturally Occurring Metalloantibody. Antibodies (Basel, Switzerland). 9. PMID 32316193 DOI: 10.3390/Antib9020010  0.753
2019 Caldwell JT, Mermelstein DJ, Walker RC, Bernstein SI, Huxford T. X-ray crystallographic and molecular dynamic analyses of Drosophila melanogaster embryonic muscle myosin define domains responsible for isoform-specific properties. Journal of Molecular Biology. PMID 31786266 DOI: 10.1016/J.Jmb.2019.11.013  0.758
2019 Mulero MC, Huxford T, Ghosh G. NF-κB, IκB, and IKK: Integral Components of Immune System Signaling. Advances in Experimental Medicine and Biology. 1172: 207-226. PMID 31628658 DOI: 10.1007/978-981-13-9367-9_10  0.666
2019 Mulero MC, Wang VY, Huxford T, Ghosh G. Genome reading by the NF-κB transcription factors. Nucleic Acids Research. PMID 31501881 DOI: 10.1093/Nar/Gkz739  0.783
2019 Maniaci B, Lipper CH, Anipindi LD, Erlandsen H, Cole JL, Stec B, Huxford T, Love JJ. Design of High-Affinity Metal-Controlled Protein Dimers. Biochemistry. PMID 30938154 DOI: 10.1021/Acs.Biochem.9B00055  0.381
2018 Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang D, Wang VY, Amaro RE, Huxford T, Ghosh G. Protein co-factors are essential for high affinity DNA binding by the nuclear factor κB RelA subunit. Biochemistry. PMID 29708732 DOI: 10.1021/Acs.Biochem.8B00158  0.78
2017 King AN, Fleming JK, Knapik SS, Visentin B, Wojciak JM, Huxford T. High-affinity, pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. Journal of Lipid Research. PMID 28507038 DOI: 10.1194/Jlr.M075614  0.32
2017 Caldwell JT, Huxford T, Melkani G, Bernstein S. X-Ray Crystallography Structures of Drosophila Striated Muscle Myosin II Biophysical Journal. 112: 266a. DOI: 10.1016/J.Bpj.2016.11.1442  0.744
2016 Geronimo I, Denning CA, Rogers WE, Othman T, Huxford T, Heidary DK, Glazer EC, Payne CM. Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants. Biochemistry. PMID 27267136 DOI: 10.1021/Acs.Biochem.6B00183  0.364
2014 Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 53: 2064-73. PMID 24611898 DOI: 10.1021/Bi401551R  0.794
2014 Caldwell JT, Melkani G, Bernstein SI, Huxford T. X-Ray Structure Determination of the First Insect Skeletal Muscle Myosin II Biophysical Journal. 106: 45a. DOI: 10.1016/J.Bpj.2013.11.330  0.757
2013 Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. Plos Biology. 11: e1001581. PMID 23776406 DOI: 10.1371/Journal.Pbio.1001581  0.773
2012 Caldwell JT, Melkani GC, Huxford T, Bernstein SI. Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system. Methods (San Diego, Calif.). 56: 25-32. PMID 22178692 DOI: 10.1016/J.Ymeth.2011.12.002  0.704
2012 Caldwell JT, Melkani GC, Huxford T, Bernstein SI. A Method for the Transgenic Expression and Purification of Skeletal Muscle Myosin II Isoforms using Drosophila Melanogaster Biophysical Journal. 102: 149a. DOI: 10.1016/J.Bpj.2011.11.813  0.703
2011 Lee CF, Hauenstein AV, Fleming JK, Gasper WC, Engelke V, Sankaran B, Bernstein SI, Huxford T. X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster. Structure (London, England : 1993). 19: 397-408. PMID 21397190 DOI: 10.1016/J.Str.2011.01.002  0.789
2011 Fleming JK, Wojciak JM, Campbell MA, Huxford T. Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. Journal of Molecular Biology. 408: 462-76. PMID 21392506 DOI: 10.1016/J.Jmb.2011.02.061  0.387
2011 Huxford T, Hoffmann A, Ghosh G. Understanding the logic of IκB:NF-κB regulation in structural terms. Current Topics in Microbiology and Immunology. 349: 1-24. PMID 20845107 DOI: 10.1007/82_2010_99  0.685
2011 Huxford T, Hoffmann A, Ghosh G. Understanding the logic of IκB:NF-κB regulation in structural terms Current Topics in Microbiology and Immunology. 349: 1-24. DOI: 10.1007/82-2010-99  0.633
2010 Lee CF, Hauenstein AV, Gasper WC, Sankaran B, Bernstein SI, Huxford T. Crystal Structure of Drosophila Unc-45, a Putative Myosin Chaperone Biophysical Journal. 98: 34a. DOI: 10.1016/J.Bpj.2009.12.199  0.79
2009 Huxford T, Ghosh G. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harbor Perspectives in Biology. 1: a000075. PMID 20066103 DOI: 10.1101/Cshperspect.A000075  0.717
2009 Wojciak JM, Zhu N, Schuerenberg KT, Moreno K, Shestowsky WS, Hiraiwa M, Sabbadini R, Huxford T. The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. Proceedings of the National Academy of Sciences of the United States of America. 106: 17717-22. PMID 19815502 DOI: 10.1073/Pnas.0906153106  0.686
2008 Shaul JD, Farina A, Huxford T. The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity. Biochemical and Biophysical Research Communications. 374: 592-7. PMID 18657515 DOI: 10.1016/J.Bbrc.2008.07.082  0.397
2008 Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T. The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. Journal of Molecular Biology. 379: 122-35. PMID 18436238 DOI: 10.1016/J.Jmb.2008.03.060  0.759
2006 Bourne Y, Hansen SB, Sulzenbacher G, Talley TT, Huxford T, Taylor P, Marchot P. Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. Journal of Molecular Neuroscience : Mn. 30: 103-4. PMID 17192648 DOI: 10.1385/Jmn:30:1:103  0.305
2006 Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P. Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica. Journal of Molecular Neuroscience : Mn. 30: 101-2. PMID 17192647 DOI: 10.1385/Jmn:30:1:101  0.364
2006 Huxford T, Ghosh G. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods in Enzymology. 407: 527-34. PMID 16757350 DOI: 10.1016/S0076-6879(05)07042-4  0.655
2006 Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. Journal of Molecular Biology. 360: 421-34. PMID 16756995 DOI: 10.1016/J.Jmb.2006.05.014  0.693
2005 Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. The Embo Journal. 24: 3635-46. PMID 16193063 DOI: 10.1038/Sj.Emboj.7600828  0.358
2004 Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Science : a Publication of the Protein Society. 13: 1767-77. PMID 15215520 DOI: 10.1110/Ps.04731004  0.7
2004 Ghosh G, Huang DB, Huxford T. Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer. Current Opinion in Structural Biology. 14: 21-7. PMID 15102445 DOI: 10.1016/J.Sbi.2004.01.004  0.679
2003 Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. The Journal of Biological Chemistry. 278: 23094-100. PMID 12686541 DOI: 10.1074/Jbc.M301022200  0.774
2002 Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. Journal of Molecular Biology. 324: 587-97. PMID 12460563 DOI: 10.2210/Pdb1My5/Pdb  0.82
2002 Huang D, Ghosh G, Huxford T, Chen Y. NF-kB regulation by IkB-α and IkB-β Acta Crystallographica Section a Foundations of Crystallography. 58: c306-c306. DOI: 10.1107/S0108767302097210  0.558
2001 Malek S, Chen Y, Huxford T, Ghosh G. IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. The Journal of Biological Chemistry. 276: 45225-35. PMID 11571291 DOI: 10.1074/Jbc.M105865200  0.764
2000 Huxford T, Malek S, Ghosh G. Preparation and crystallization of dynamic NF-kappa B.Ikappa B complexes. The Journal of Biological Chemistry. 275: 32800-6. PMID 10906335 DOI: 10.1074/Jbc.M006037200  0.751
2000 Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G. Mechanism of I kappa B alpha binding to NF-kappa B dimers. The Journal of Biological Chemistry. 275: 29840-6. PMID 10882738 DOI: 10.1074/Jbc.M004899200  0.803
1999 Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harbor Symposia On Quantitative Biology. 64: 533-40. PMID 11232330 DOI: 10.1101/Sqb.1999.64.533  0.714
1998 Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell. 95: 759-70. PMID 9865694 DOI: 10.1016/S0092-8674(00)81699-2  0.775
1998 Malek S, Huxford T, Ghosh G. Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. The Journal of Biological Chemistry. 273: 25427-35. PMID 9738011 DOI: 10.1074/Jbc.273.39.25427  0.784
1997 Huang DB, Huxford T, Chen YQ, Ghosh G. The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. Structure (London, England : 1993). 5: 1427-36. PMID 9384558 DOI: 10.1016/S0969-2126(97)00293-1  0.683
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