Osamu Hayaishi - Publications

Affiliations: 
Kyoto University, Kyōto-shi, Kyōto-fu, Japan 
Area:
Biochemistry

299 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D(2) is crucial for seizure suppression and postictal sleep. Experimental Neurology. 253: 82-90. PMID 24333565 DOI: 10.1016/j.expneurol.2013.12.002  0.56
2013 Kallweit U, Aritake K, Bassetti CL, Blumenthal S, Hayaishi O, Linnebank M, Baumann CR, Urade Y. Elevated CSF histamine levels in multiple sclerosis patients. Fluids and Barriers of the Cns. 10: 19. PMID 23659456 DOI: 10.1186/2045-8118-10-19  0.56
2011 Urade Y, Hayaishi O. Prostaglandin D2 and sleep/wake regulation. Sleep Medicine Reviews. 15: 411-8. PMID 22024172 DOI: 10.1016/j.smrv.2011.08.003  0.56
2011 Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10067-75. PMID 21734299 DOI: 10.1523/JNEUROSCI.6730-10.2011  0.56
2011 Huang ZL, Urade Y, Hayaishi O. The role of adenosine in the regulation of sleep. Current Topics in Medicinal Chemistry. 11: 1047-57. PMID 21401496 DOI: 10.2174/156802611795347654  0.56
2011 Huang ZL, Urade Y, Hayaishi O. Key roles of the histaminergic system in sleep-wake regulation Sleep and Biological Rhythms. 9: 34-37. DOI: 10.1111/j.1479-8425.2010.00471.x  0.56
2010 Urade Y, Hayaishi O. Crucial role of prostaglandin D2 and adenosine in sleep regulation: Experimental evidence from pharmacological approaches to gene-knockout mice Future Neurology. 5: 363-376. DOI: 10.2217/fnl.10.18  0.56
2009 Kumasaka T, Aritake K, Ago H, Irikura D, Tsurumura T, Yamamoto M, Miyano M, Urade Y, Hayaishi O. Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase. The Journal of Biological Chemistry. 284: 22344-52. PMID 19546224 DOI: 10.1074/jbc.M109.018341  0.56
2008 Oishi Y, Huang ZL, Fredholm BB, Urade Y, Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 105: 19992-7. PMID 19066225 DOI: 10.1073/pnas.0810926105  0.56
2008 Hayaishi O, Urade Y. Prostaglandins and the regulation of sleep and wakefulness Neurochemistry of Sleep and Wakefulness. 363-386. DOI: 10.1017/CBO9780511541674.014  0.56
2007 Huang ZL, Urade Y, Hayaishi O. Prostaglandins and adenosine in the regulation of sleep and wakefulness. Current Opinion in Pharmacology. 7: 33-8. PMID 17129762 DOI: 10.1016/j.coph.2006.09.004  0.56
2006 Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi N, Nambu F, Narumiya S, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proceedings of the National Academy of Sciences of the United States of America. 103: 17949-54. PMID 17093043 DOI: 10.1073/pnas.0608581103  0.68
2006 Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y, Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 4687-92. PMID 16537376 DOI: 10.1073/pnas.0600451103  0.56
2005 Gallopin T, Luppi PH, Cauli B, Urade Y, Rossier J, Hayaishi O, Lambolez B, Fort P. The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus. Neuroscience. 134: 1377-90. PMID 16039802 DOI: 10.1016/j.neuroscience.2005.05.045  0.56
2005 Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nature Neuroscience. 8: 858-9. PMID 15965471 DOI: 10.1038/nn1491  0.56
2005 Hong ZY, Huang ZL, Qu WM, Eguchi N, Urade Y, Hayaishi O. An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. Journal of Neurochemistry. 92: 1542-9. PMID 15748171 DOI: 10.1111/j.1471-4159.2004.02991.x  0.56
2005 Hayaishi O, Coon MJ, Estabrook RW, Que L, Yamamoto S. Biochemical and Biophysical Research Communications: Preface Biochemical and Biophysical Research Communications. 338: 1. DOI: 10.1016/j.bbrc.2005.10.017  0.56
2004 Hayaishi O, Urade Y, Eguchi N, Huang ZL. Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. Archives Italiennes De Biologie. 142: 533-9. PMID 15493554  0.56
2004 Hayaishi O, Huang ZL. Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission. Drug News & Perspectives. 17: 105-9. PMID 15098064 DOI: 10.1358/dnp.2004.17.2.829043  0.56
2004 Urade Y, Eguchi N, Aritake K, Hayaishi O. [Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 123: 5-13. PMID 14695453 DOI: 10.1254/fpj.123.5  0.56
2004 Sakata M, Eguchi N, Qu WM, Huang ZL, Chen JF, Schwarzschild MA, Urade Y, Hayaishi O. Lack of rebound of non-rapid eye movement sleep after sleep deprivation in adenosine A2A receptor knockout mice Sleep and Biological Rhythms. 2: S56. DOI: 10.1111/j.1479-8425.2004.00115.x  0.56
2004 Qu WM, Huang ZL, Mochizuki T, Eguchi N, Chen JF, Schwarzschild MA, Fink SJ, Urade Y, Hayaishi O. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 Sleep and Biological Rhythms. 2: S55. DOI: 10.1111/j.1479-8425.2004.00114.x  0.56
2004 Huang ZL, Qu WM, Eguchi N, Chu M, Okada T, Sato Y, Sakata M, Mochizuki T, Urade Y, Hayaishi O. Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E2 and D2 Sleep and Biological Rhythms. 2: S21-S22. DOI: 10.1111/j.1479-8425.2004.00094.x  0.56
2004 Eguchi N, Qu WM, Huang ZL, Sakata M, Narumiya S, Chen JF, Urade Y, Hayaishi O. Molecular mechanism of prostaglandin D2-mediated non-REM sleep homeostasis studied by gene-knockout mice Sleep and Biological Rhythms. 2: S17-S18. DOI: 10.1111/j.1479-8425.2004.00092.x  0.68
2004 Hayaishi O, Urade Y. Sleep and Biological Rhythms: Foreword Sleep and Biological Rhythms. 2: S1. DOI: 10.1111/j.1479-8425.2004.00082.x  0.56
2003 Urade Y, Eguchi N, Qu WM, Sakata M, Huang ZL, Chen JF, Schwarzschild MA, Fink JS, Hayaishi O. Sleep regulation in adenosine A2A receptor-deficient mice. Neurology. 61: S94-6. PMID 14663019  0.56
2003 Okada T, Mochizuki T, Huang ZL, Eguchi N, Sugita Y, Urade Y, Hayaishi O. Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep. Biochemical and Biophysical Research Communications. 312: 29-34. PMID 14630012 DOI: 10.1016/j.bbrc.2003.09.220  0.56
2003 Huang ZL, Sato Y, Mochizuki T, Okada T, Qu WM, Yamatodani A, Urade Y, Hayaishi O. Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5975-83. PMID 12853415  0.56
2003 Irikura D, Kumasaka T, Yamamoto M, Ago H, Miyano M, Kubata KB, Sakai H, Hayaishi O, Urade Y. Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. Journal of Biochemistry. 133: 29-32. PMID 12761195 DOI: 10.1093/jb/mvg006  0.56
2003 Inui T, Ohkubo T, Emi M, Irikura D, Hayaishi O, Urade Y. Characterization of the unfolding process of lipocalin-type prostaglandin D synthase. The Journal of Biological Chemistry. 278: 2845-52. PMID 12441340 DOI: 10.1074/jbc.M209934200  0.56
2002 Hayaishi O, Urade Y. Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 12-5. PMID 11843094  0.56
2002 Lazarus M, Kubata BK, Eguchi N, Fujitani Y, Urade Y, Hayaishi O. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Archives of Biochemistry and Biophysics. 397: 336-41. PMID 11795891 DOI: 10.1006/abbi.2001.2614  0.56
2001 Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O. An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience. 107: 653-63. PMID 11720788 DOI: 10.1016/S0306-4522(01)00383-9  0.56
2001 Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T, Narumiya S, Urade Y, Hayaishi O. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 98: 11674-9. PMID 11562489 DOI: 10.1073/pnas.201398898  0.68
2001 Huang ZL, Qu WM, Li WD, Mochizuki T, Eguchi N, Watanabe T, Urade Y, Hayaishi O. Arousal effect of orexin A depends on activation of the histaminergic system. Proceedings of the National Academy of Sciences of the United States of America. 98: 9965-70. PMID 11493714 DOI: 10.1073/pnas.181330998  0.56
2000 Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. The Journal of Experimental Medicine. 192: 1327-38. PMID 11067881 DOI: 10.1084/jem.192.9.1327  0.56
2000 Urade Y, Hayaishi O. Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochimica Et Biophysica Acta. 1482: 259-71. PMID 11058767 DOI: 10.1016/S0167-4838(00)00161-8  0.56
2000 Beuckmann CT, Lazarus M, Gerashchenko D, Mizoguchi A, Nomura S, Mohri I, Uesugi A, Kaneko T, Mizuno N, Hayaishi O, Urade Y. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. The Journal of Comparative Neurology. 428: 62-78. PMID 11058225 DOI: 10.1002/1096-9861(20001204)428:1<62::AID-CNE6>3.0.CO;2-E  0.56
2000 Beuckmann CT, Fujimori K, Urade Y, Hayaishi O. Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. Neurochemical Research. 25: 733-8. PMID 10905636 DOI: 10.1023/A:1007579507804  0.56
2000 Pinzar E, Miyano M, Kanaoka Y, Urade Y, Hayaishi O. Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis. The Journal of Biological Chemistry. 275: 31239-44. PMID 10871602 DOI: 10.1074/jbc.M000750200  0.56
2000 Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. European Journal of Biochemistry / Febs. 267: 3315-22. PMID 10824118 DOI: 10.1046/j.1432-1327.2000.01362.x  0.56
2000 Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 97: 4903-7. PMID 10781097 DOI: 10.1073/pnas.090093997  0.56
2000 Gerashchenko D, Okano Y, Urade Y, Inoué S, Hayaishi O. Strong rebound of wakefulness follows prostaglandin D2- or adenosine A2a receptor agonist-induced sleep. Journal of Sleep Research. 9: 81-7. PMID 10733693 DOI: 10.1046/j.1365-2869.2000.00175.x  0.56
2000 Yamamoto S, Ueda N, Mahmud I, Yamaguchi H, Yamashita R, Yamamoto K, Ishimura K, Urade Y, Kanaoka Y, Hayaishi O. Fatty acid cyclooxygenase induction accompanied by prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. Biofactors (Oxford, England). 11: 57-61. PMID 10705961  0.56
2000 Urade Y, Hayaishi O. Prostaglandin D synthase: structure and function. Vitamins and Hormones. 58: 89-120. PMID 10668396  0.56
1999 Beuckmann CT, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase (beta-trace) binds non-substrate lipophilic ligands. Advances in Experimental Medicine and Biology. 469: 55-60. PMID 10667310  0.56
1999 Urade Y, Eguchi Y, Eguchi N, Kijima Y, Matsuura Y, Oda H, Seiki K, Hayaishi O. Secretion of lipocalin-type prostaglandin D synthase (beta-trace) from human heart to plasma during coronary circulation. Advances in Experimental Medicine and Biology. 469: 49-54. PMID 10667309  0.56
1999 Yamamoto S, Ueda N, Mahmud I, Yamaguchi H, Yamashita R, Yamamoto K, Ishimura K, Urade Y, Kanaoka Y, Hayaishi O. Fatty acid cyclooxygenase induction and prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. Advances in Experimental Medicine and Biology. 469: 17-21. PMID 10667304  0.56
1999 Inui T, Ohkubo T, Urade Y, Hayaishi O. Enhancement of lipocalin-type prostaglandin D synthase enzyme activity by guanidine hydrochloride. Biochemical and Biophysical Research Communications. 266: 641-6. PMID 10603301 DOI: 10.1006/bbrc.1999.1881  0.56
1999 Beuckmann CT, Aoyagi M, Okazaki I, Hiroike T, Toh H, Hayaishi O, Urade Y. Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. Biochemistry. 38: 8006-13. PMID 10387044 DOI: 10.1021/bi990261p  0.56
1999 Satoh S, Matsumura H, Koike N, Tokunaga Y, Maeda T, Hayaishi O. Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor agonist. The European Journal of Neuroscience. 11: 1587-97. PMID 10215911 DOI: 10.1046/j.1460-9568.1999.00569.x  0.56
1999 Urade Y, Hayaishi O. Prostaglandin D2 and sleep regulation. Biochimica Et Biophysica Acta. 1436: 606-15. PMID 9989291 DOI: 10.1016/S0005-2760(98)00163-5  0.56
1999 Eguchi N, Minami T, Shirafuji N, Kanaoka Y, Tanaka T, Nagata A, Yoshida N, Urade Y, Ito S, Hayaishi O. Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 726-30. PMID 9892701 DOI: 10.1073/pnas.96.2.726  0.56
1998 Fujitani Y, Urade Y, Hayaishi O. [Sleep-promoting substances]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 35: 811-6. PMID 10064966  0.56
1998 Kilunga Kubata B, Eguchi N, Urade Y, Yamashita K, Mitamura T, Tai K, Hayaishi O, Horii T. Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. The Journal of Experimental Medicine. 188: 1197-202. PMID 9743538 DOI: 10.1084/jem.188.6.1197  0.56
1998 Gerashchenko D, Beuckmann CT, Kanaoka Y, Eguchi N, Gordon WC, Urade Y, Bazan NG, Hayaishi O. Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes. Journal of Neurochemistry. 71: 937-45. PMID 9721719  0.56
1998 Satoh S, Matsumura H, Hayaishi O. Involvement of adenosine A2A receptor in sleep promotion. European Journal of Pharmacology. 351: 155-62. PMID 9686998 DOI: 10.1016/S0014-2999(98)00302-1  0.56
1998 Scammell T, Gerashchenko D, Urade Y, Onoe H, Saper C, Hayaishi O. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proceedings of the National Academy of Sciences of the United States of America. 95: 7754-9. PMID 9636223 DOI: 10.1073/pnas.95.13.7754  0.56
1998 García-Fernández LF, Urade Y, Hayaishi O, Bernal J, Muñoz A. Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. Brain Research. Molecular Brain Research. 55: 321-30. PMID 9582446 DOI: 10.1016/S0169-328X(98)00015-1  0.56
1998 Tokugawa Y, Kunishige I, Kubota Y, Shimoya K, Nobunaga T, Kimura T, Saji F, Murata Y, Eguchi N, Oda H, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biology of Reproduction. 58: 600-7. PMID 9475419 DOI: 10.1095/biolreprod58.2.600  0.56
1998 Gerashchenko DY, Beuckmann CT, Marcheselli VL, Gordon WC, Kanaoka Y, Eguchi N, Urade Y, Hayaishi O, Bazan NG. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Investigative Ophthalmology & Visual Science. 39: 198-203. PMID 9430563  0.56
1998 Kubata BK, Eguchi N, Urade Y, Yamashita K, Horii T, Hayaishi O. Evidence of prostaglandin production by the human malaria parasite, Plasmodium falciparum South African Journal of Science. 94: 285-286.  0.56
1997 Suzuki T, Watanabe K, Kanaoka Y, Sato T, Hayaishi O. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochemical and Biophysical Research Communications. 241: 288-93. PMID 9425264 DOI: 10.1006/bbrc.1997.7803  0.56
1997 Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O. Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Proceedings of the National Academy of Sciences of the United States of America. 94: 14689-94. PMID 9405674 DOI: 10.1073/pnas.94.26.14689  0.56
1997 Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase in human megakaryoblastic cells. The Journal of Biological Chemistry. 272: 28263-6. PMID 9353279 DOI: 10.1074/jbc.272.45.28263  0.56
1997 Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell. 90: 1085-95. PMID 9323136 DOI: 10.1016/S0092-8674(00)80374-8  0.56
1997 García-Fernández LF, Rausell E, Urade Y, Hayaishi O, Bernal J, Muñoz A. Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain. The European Journal of Neuroscience. 9: 1566-73. PMID 9283811 DOI: 10.1111/j.1460-9568.1997.tb01514.x  0.56
1997 Ezashi T, Sakamoto K, Miwa K, Okuda-Ashitaka E, Ito S, Hayaishi O. Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor. Gene. 190: 271-8. PMID 9197544 DOI: 10.1016/S0378-1119(97)00012-7  0.56
1997 Watanabe K, Kurihara K, Tokunaga Y, Hayaishi O. Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases. Biochemical and Biophysical Research Communications. 235: 148-52. PMID 9196052 DOI: 10.1006/bbrc.1997.6708  0.56
1997 Tanaka T, Urade Y, Kimura H, Eguchi N, Nishikawa A, Hayaishi O. Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter. The Journal of Biological Chemistry. 272: 15789-95. PMID 9188476 DOI: 10.1074/jbc.272.25.15789  0.56
1997 Ram A, Pandey HP, Matsumura H, Kasahara-Orita K, Nakajima T, Takahata R, Satoh S, Terao A, Hayaishi O. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Research. 751: 81-9. PMID 9098570 DOI: 10.1016/S0006-8993(96)01401-1  0.56
1997 Yamashima T, Sakuda K, Tohma Y, Yamashita J, Oda H, Irikura D, Eguchi N, Beuckmann CT, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2376-82. PMID 9065498  0.56
1996 Toh H, Kubodera H, Nakajima N, Sekiya T, Eguchi N, Tanaka T, Urade Y, Hayaishi O. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Engineering. 9: 1067-82. PMID 9010921  0.56
1996 Takahata R, Matsumura H, Eguchi N, Kantha SS, Satoh S, Sakai T, Kondo N, Hayaishi O. Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 54: 77-81. PMID 8992498 DOI: 10.1016/S0952-3278(96)90085-X  0.56
1996 Melegos DN, Diamandis EP, Oda H, Urade Y, Hayaishi O. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clinical Chemistry. 42: 1984-91. PMID 8969637  0.56
1996 Okuda-Ashitaka E, Sakamoto K, Ezashi T, Miwa K, Ito S, Hayaishi O. Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype. The Journal of Biological Chemistry. 271: 31255-61. PMID 8940129 DOI: 10.1074/jbc.271.49.31255  0.56
1996 Urade Y, Hayaishi O, Matsumura H, Watanabe K. Molecular mechanism of sleep regulation by prostaglandin D2. Journal of Lipid Mediators and Cell Signalling. 14: 71-82. PMID 8906548 DOI: 10.1016/0929-7855(96)01511-8  0.56
1996 Minami T, Okuda-Ashitaka E, Mori H, Ito S, Hayaishi O. Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. The Journal of Pharmacology and Experimental Therapeutics. 278: 1146-52. PMID 8819497  0.56
1996 Beuckmann CT, Gordon WC, Kanaoka Y, Eguchi N, Marcheselli VL, Gerashchenko DY, Urade Y, Hayaishi O, Bazan NG. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6119-24. PMID 8815894  0.56
1996 Blödorn B, Mäder M, Urade Y, Hayaishi O, Felgenhauer K, Brück W. Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. Neuroscience Letters. 209: 117-20. PMID 8761996 DOI: 10.1016/0304-3940(96)12614-8  0.56
1996 Satoh S, Matsumura H, Suzuki F, Hayaishi O. Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. Proceedings of the National Academy of Sciences of the United States of America. 93: 5980-4. PMID 8650205  0.56
1996 Garcia-Fernandez LF, Rausell E, Fairen A, Urade Y, Hayaishi O, Bernal J, Munoz A. Rat brain prostaglandin D2 synthase is regulated by thyroid hormone in vivo Prostaglandins. 51: 302-306. DOI: 10.1016/0090-6980(96)86807-9  0.56
1996 Eguchi N, Kanaoka Y, Urade Y, Hayaishi O. Expression and cellular localization of β-trace in genital organs Prostaglandins. 51: 298. DOI: 10.1016/0090-6980(96)86803-1  0.56
1996 Yamashima T, Sakuda K, Tohma Y, Kida S, Yamashita J, Eguchi N, Kanaoka Y, Irikura D, Urade Y, Hayaishi O. Prostaglandin D synthase in human arachnoid, arachnoid villi and meningiomas Prostaglandins. 51: 287. DOI: 10.1016/0090-6980(96)86792-X  0.56
1996 Matsumura H, Satoh S, Pandey HP, Ram A, Gerashchenko D, Kasahara K, Nakajima T, Hayaishi O. Role of prostaglandin D2 in the regulation of sleep Prostaglandins. 51: 282. DOI: 10.1016/0090-6980(96)86787-6  0.56
1995 Minami T, Onaka M, Okuda-Ashitaka E, Mori H, Ito S, Hayaishi O. L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2. Neuroscience Letters. 201: 239-42. PMID 8786849 DOI: 10.1016/0304-3940(95)12176-5  0.56
1995 Urade Y, Watanabe K, Hayaishi O. Prostaglandin D, E, and F synthases. Journal of Lipid Mediators and Cell Signalling. 12: 257-73. PMID 8777570 DOI: 10.1016/0929-7855(95)00032-L  0.56
1995 Pandey HP, Ram A, Matsumura H, Hayaishi O. Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. Biochemistry and Molecular Biology International. 37: 431-7. PMID 8595382  0.56
1995 Osaka T, Hayaishi O. Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. Neuroscience Research. 23: 257-68. PMID 8545074 DOI: 10.1016/0168-0102(95)00948-5  0.56
1995 Urade Y, Tanaka T, Eguchi N, Kikuchi M, Kimura H, Toh H, Hayaishi O. Structural and functional significance of cysteine residues of glutathione-independent prostaglandin D synthase. Identification of Cys65 as an essential thiol. The Journal of Biological Chemistry. 270: 1422-8. PMID 7836410  0.56
1995 Sakamoto K, Ezashi T, Miwa K, Okuda-Ashitaka E, Houtani T, Sugimoto T, Ito S, Hayaishi O. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 259-61. PMID 7732848  0.56
1995 Sakamoto K, Miwa K, Ezashi T, Okuda-Ashitaka E, Okuda K, Houtani T, Sugimoto T, Ito S, Hayaishi O. Expression of mRNA encoding the prostaglandin F2 alpha receptor in bovine corpora lutea throughout the oestrous cycle and pregnancy. Journal of Reproduction and Fertility. 103: 99-105. PMID 7707306  0.56
1995 Minami T, Nishihara I, Ito S, Sakamoto K, Hyodo M, Hayaishi O. Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice. Pain. 61: 285-90. PMID 7659439 DOI: 10.1016/0304-3959(94)00183-F  0.56
1995 Minami T, Nishihara I, Sakamoto K, Ito S, Hyodo M, Hayaishi O. Blockade by ONO-NT-012, a unique prostanoid analogue, of prostaglandin E2-induced allodynia in conscious mice. British Journal of Pharmacology. 115: 73-6. PMID 7647986  0.56
1995 Pandey HP, Ram A, Matsumura H, Satoh S, Hayaishi O. Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. Biochemical and Biophysical Research Communications. 213: 625-9. PMID 7646520 DOI: 10.1006/bbrc.1995.2177  0.56
1995 Matsumura H, Kinoshita G, Satoh S, Osaka T, Hayaishi O. A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal. Journal of Neuroscience Methods. 57: 145-9. PMID 7609577 DOI: 10.1016/0165-0270(94)00107-R  0.56
1995 Nishihara I, Minami T, Uda R, Ito S, Hyodo M, Hayaishi O. Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice. Brain Research. 677: 138-44. PMID 7606458 DOI: 10.1016/0006-8993(95)00133-B  0.56
1995 Vesin MF, Urade Y, Hayaishi O, Droz B. Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 470-6. PMID 7529829  0.56
1995 Nishihara I, Minami T, Watanabe Y, Ito S, Hayaishi O. Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord. Neuroscience Letters. 196: 57-60. PMID 7501257 DOI: 10.1016/0304-3940(95)11839-O  0.56
1995 Hayaishi O, Matsumura H. Prostaglandins and sleep. Advances in Neuroimmunology. 5: 211-6. PMID 7496614 DOI: 10.1016/0960-5428(95)00010-Y  0.56
1994 Ito S, Sakamoto K, Mochizuki-Oda N, Ezashi T, Miwa K, Okuda-Ashitaka E, Shevchenko VI, Kiso Y, Hayaishi O. Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. Biochemical and Biophysical Research Communications. 200: 756-62. PMID 8179609 DOI: 10.1006/bbrc.1994.1515  0.56
1994 Koyama Y, Hayaishi O. Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. Brain Research Bulletin. 33: 367-72. PMID 8124575 DOI: 10.1016/0361-9230(94)90278-X  0.56
1994 Watanabe K, Urade Y, Mäder M, Murphy C, Hayaishi O. Identification of beta-trace as prostaglandin D synthase. Biochemical and Biophysical Research Communications. 203: 1110-6. PMID 8093029 DOI: 10.1006/bbrc.1994.2297  0.56
1994 Koyama Y, Hayaishi O. Firing of neurons in the preoptic/anterior hypothalamic areas in rat: its possible involvement in slow wave sleep and paradoxical sleep. Neuroscience Research. 19: 31-8. PMID 8008233 DOI: 10.1016/0168-0102(94)90005-1  0.56
1994 Matsumura H, Nakajima T, Osaka T, Satoh S, Kawase K, Kubo E, Kantha SS, Kasahara K, Hayaishi O. Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. Proceedings of the National Academy of Sciences of the United States of America. 91: 11998-2002. PMID 7991572 DOI: 10.1073/pnas.91.25.11998  0.56
1994 Sri Kantha S, Matsumura H, Kubo E, Kawase K, Takahata R, Serhan CN, Hayaishi O. Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 51: 87-93. PMID 7972271 DOI: 10.1016/0952-3278(94)90083-3  0.56
1994 Minami T, Nishihara I, Uda R, Ito S, Hyodo M, Hayaishi O. Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice. British Journal of Pharmacology. 112: 735-40. PMID 7921597  0.56
1994 Minami T, Nishihara I, Uda R, Ito S, Hyodo M, Hayaishi O. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice. Pain. 57: 225-31. PMID 7916453 DOI: 10.1016/0304-3959(94)90227-5  0.56
1994 Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. Pain. 57: 217-23. PMID 7916452 DOI: 10.1016/0304-3959(94)90226-7  0.56
1994 Satoh S, Matsumura H, Nakajima T, Onoe H, Sakai K, Nakajima T, Jouvet M, Hayaishi O. Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. Neuroscience Research. 21: 41-50. PMID 7708292 DOI: 10.1016/0168-0102(94)90066-3  0.56
1994 Sakamoto K, Ezashi T, Miwa K, Okuda-Ashitaka E, Houtani T, Sugimoto T, Ito S, Hayaishi O. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. The Journal of Biological Chemistry. 269: 3881-6. PMID 7508922  0.56
1993 Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N, Hayaishi O. Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proceedings of the National Academy of Sciences of the United States of America. 90: 9070-4. PMID 8415655  0.56
1993 Okuda-Ashitaka E, Sakamoto K, Giles H, Ito S, Hayaishi O. Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. Biochimica Et Biophysica Acta. 1176: 148-54. PMID 8384001 DOI: 10.1016/0167-4889(93)90190-Z  0.56
1993 Hayaishi O, Matsumura H, Urade Y. Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep. Journal of Lipid Mediators. 6: 429-31. PMID 8358001  0.56
1993 Takahata R, Matsumura H, Kantha SS, Kubo E, Kawase K, Sakai T, Hayaishi O. Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats. Brain Research. 623: 65-71. PMID 8221095 DOI: 10.1016/0006-8993(93)90010-K  0.56
1992 Onoe H, Watanabe Y, Ono K, Koyama Y, Hayaishi O. Prostaglandin E2 exerts an awaking effect in the posterior hypothalamus at a site distinct from that mediating its febrile action in the anterior hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 2715-25. PMID 1613554  0.56
1992 Igarashi M, Nagata A, Toh H, Urade Y, Hayaishi O. Structural organization of the gene for prostaglandin D synthase in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. 89: 5376-80. PMID 1608945  0.56
1992 Chen LY, Watanabe K, Hayaishi O. Purification and characterization of prostaglandin F synthase from bovine liver. Archives of Biochemistry and Biophysics. 296: 17-26. PMID 1605628 DOI: 10.1016/0003-9861(92)90539-9  0.56
1992 Eguchi N, Kaneko T, Urade Y, Hayashi H, Hayaishi O. Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. The Journal of Pharmacology and Experimental Therapeutics. 262: 1110-20. PMID 1527717  0.56
1992 Fujimoto N, Kaneko T, Eguchi N, Urade Y, Mizuno N, Hayaishi O. Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain. Neuroscience. 49: 591-606. PMID 1501767 DOI: 10.1016/0306-4522(92)90229-U  0.56
1992 Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Allodynia evoked by intrathecal administration of prostaglandin F2 alpha to conscious mice. Pain. 50: 223-9. PMID 1408321 DOI: 10.1016/0304-3959(92)90166-9  0.56
1992 Kuchinke W, Barski O, Watanabe K, Hayaishi O. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Biochemical and Biophysical Research Communications. 183: 1238-46. PMID 1339268 DOI: 10.1016/S0006-291X(05)80323-7  0.56
1992 Ito S, Sugama K, Inagaki N, Fukui H, Giles H, Wada H, Hayaishi O. Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. Glia. 6: 67-74. PMID 1324890 DOI: 10.1002/glia.440060109  0.56
1991 Watanabe K, Fujii Y, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S, Hayaishi O. Expression of bovine lung prostaglandin F synthase in Escherichia coli. Biochemical and Biophysical Research Communications. 181: 272-8. PMID 1958196 DOI: 10.1016/S0006-291X(05)81413-5  0.56
1991 Nakajima M, Goh Y, Azuma I, Hayaishi O. Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 229: 411-3. PMID 1937072 DOI: 10.1007/BF00166301  0.56
1991 Matsumura H, Takahata R, Hayaishi O. Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase. Proceedings of the National Academy of Sciences of the United States of America. 88: 9046-50. PMID 1924366  0.56
1991 Islam F, Watanabe Y, Morii H, Hayaishi O. Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds. Archives of Biochemistry and Biophysics. 289: 161-6. PMID 1910313 DOI: 10.1016/0003-9861(91)90456-S  0.56
1991 Tsubokura S, Watanabe Y, Ehara H, Imamura K, Sugimoto O, Kagamiyama H, Yamamoto S, Hayaishi O. Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain. Brain Research. 543: 15-24. PMID 1905180 DOI: 10.1016/0006-8993(91)91043-Z  0.56
1991 Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proceedings of the National Academy of Sciences of the United States of America. 88: 4020-4. PMID 1902577  0.56
1991 Ito S, Negishi M, Mochizuki-Oda N, Yokohama H, Hayaishi O. Sodium fluoride mimics the effect of prostaglandin E2 on catecholamine release from bovine adrenal chromaffin cells. Journal of Neurochemistry. 56: 44-51. PMID 1898968  0.56
1991 Watanabe K, Fujii Y, Hayashi H, Urade Y, Hayaishi O. The structure and function of prostaglandin F synthase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 85-8. PMID 1825592  0.56
1991 Hayaishi O, Matsumura H, Onoe H, Koyama Y, Watanabe Y. Sleep-wake regulation by PGD2 and E2. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 723-6. PMID 1825402  0.56
1991 Onoe H, Watanabe Y, Tamura M, Hayaishi O. REM sleep-associated hemoglobin oxygenation in the monkey forebrain studied using near-infrared spectrophotometry. Neuroscience Letters. 129: 209-13. PMID 1745402 DOI: 10.1016/0304-3940(91)90463-4  0.56
1991 Ito S, Negishi M, Sugama K, Okuda-Ashitaka E, Hayaishi O. Signal transduction coupled to prostaglandin D2. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 371-4. PMID 1705384  0.56
1991 Takeuchi Y, Morii H, Tamura M, Hayaishi O, Watanabe Y. A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acid. Archives of Biochemistry and Biophysics. 289: 33-8. PMID 1654847 DOI: 10.1016/0003-9861(91)90438-O  0.56
1990 Urade Y, Ujihara M, Horiguchi Y, Igarashi M, Nagata A, Ikai K, Hayaishi O. Mast cells contain spleen-type prostaglandin D synthetase. The Journal of Biological Chemistry. 265: 371-5. PMID 2403560  0.56
1990 Hayashi H, Fujii Y, Watanabe K, Hayaishi O. Enzymatic formation of prostaglandin F2 alpha in human brain. Neurochemical Research. 15: 385-92. PMID 2388711 DOI: 10.1007/BF00969923  0.56
1990 Urade Y, Watanabe K, Eguchi N, Fujii Y, Hayaishi O. 9 alpha,11 beta-prostaglandin F2 formation in various bovine tissues. Different isozymes of prostaglandin D2 11-ketoreductase, contribution of prostaglandin F synthetase and its cellular localization. The Journal of Biological Chemistry. 265: 12029-35. PMID 2365709  0.56
1990 Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. Brain Research. 510: 26-32. PMID 2322844 DOI: 10.1016/0006-8993(90)90723-O  0.56
1990 Negishi M, Ito S, Hayaishi O. Involvement of protein kinase C in prostaglandin E2-induced catecholamine release from cultured bovine adrenal chromaffin cells. The Journal of Biological Chemistry. 265: 6182-8. PMID 2318853  0.56
1990 Nishino S, Mignot E, Kilduff TS, Sakai T, Hayaishi O, Dement WC. Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs. Biological Psychiatry. 28: 904-10. PMID 2268692 DOI: 10.1016/0006-3223(90)90570-R  0.56
1990 Mori K, Ikeda J, Hayaishi O. Monoclonal antibody R2D5 reveals midsagittal radial glial system in postnatally developing and adult brainstem. Proceedings of the National Academy of Sciences of the United States of America. 87: 5489-93. PMID 2196568  0.56
1990 Fujii Y, Watanabe K, Hayashi H, Urade Y, Kuramitsu S, Kagamiyama H, Hayaishi O. Purification and characterization of rho-crystallin from Japanese common bullfrog lens. The Journal of Biological Chemistry. 265: 9914-23. PMID 2190986  0.56
1990 Negishi M, Ito S, Hayaishi O. Arachidonic acid stimulates phosphoinositide metabolism and catecholamine release from bovine adrenal chromaffin cells. Biochemical and Biophysical Research Communications. 169: 773-9. PMID 2162673 DOI: 10.1016/0006-291X(90)90398-7  0.56
1990 Ito S, Okuda E, Sugama K, Negishi M, Hayaishi O. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British Journal of Pharmacology. 99: 13-4. PMID 2158830  0.56
1990 Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Synergistic effect of prostaglandin E2 and ouabain on catecholamine release from cultured bovine adrenal chromaffin cells. Journal of Neurochemistry. 54: 86-95. PMID 2152800  0.56
1990 Islam F, Watanabe Y, Hayaishi O. Inhibition of rat brain prostaglandin D synthase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Biochemistry International. 22: 601-5. PMID 2127671  0.56
1990 Islam F, Urade Y, Watanabe Y, Hayaishi O. A particle concentration fluorescence immunoassay for prostaglandin D synthase in the rat central nervous system. Archives of Biochemistry and Biophysics. 277: 290-5. PMID 2106829 DOI: 10.1016/0003-9861(90)90581-I  0.56
1990 Matsumura K, Watanabe Y, Onoe H, Watanabe Y, Hayaishi O. High density of prostaglandin E2 binding sites in the anterior wall of the 3rd ventricle: a possible site of its hyperthermic action. Brain Research. 533: 147-51. PMID 1964828 DOI: 10.1016/0006-8993(90)91808-T  0.56
1989 Nishino S, Mignot E, Fruhstorfer B, Dement WC, Hayaishi O. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Proceedings of the National Academy of Sciences of the United States of America. 86: 2483-7. PMID 2928344  0.56
1989 Watanabe Y, Watanabe Y, Hamada K, Bommelaer-Bayt MC, Dray F, Kaneko T, Yumoto N, Hayaishi O. Distinct localization of prostaglandin D2, E2 and F2 alpha binding sites in monkey brain. Brain Research. 478: 143-8. PMID 2924110 DOI: 10.1016/0006-8993(89)91486-8  0.56
1989 Hayashi H, Fujii Y, Watanabe K, Urade Y, Hayaishi O. Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lung. The Journal of Biological Chemistry. 264: 1036-40. PMID 2910843  0.44
1989 Matsumura H, Honda K, Choi WS, Inoué S, Sakai T, Hayaishi O. Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. Proceedings of the National Academy of Sciences of the United States of America. 86: 5666-9. PMID 2748610  0.56
1989 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Hayashi H, Kagamiyama H, Nakanishi S, Hayaishi O. Prostaglandin F synthetase--a dual function enzyme. Progress in Clinical and Biological Research. 290: 351-64. PMID 2726822  0.56
1989 Matsumura H, Honda K, Goh Y, Ueno R, Sakai T, Inoué S, Hayaishi O. Awaking effect of prostaglandin E2 in freely moving rats. Brain Research. 481: 242-9. PMID 2720378 DOI: 10.1016/0006-8993(89)90800-7  0.56
1989 Hayashi H, Fujii Y, Watanabe K, Urade Y, Hayaishi O. Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver. Progress in Clinical and Biological Research. 290: 365-79. PMID 2657759  0.56
1989 Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O. Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence. The Journal of Biological Chemistry. 264: 1041-5. PMID 2642896  0.44
1989 Nishino S, Ueno R, Ohishi K, Sakai T, Hayaishi O. Salivary prostaglandin concentrations: possible state indicators for major depression. The American Journal of Psychiatry. 146: 365-8. PMID 2627202  0.4
1989 Ito S, Negishi M, Yokohama H, Tanaka T, Hayashi H, Katada T, Ui M, Hayaishi O. Enhancement of catecholamine release may be mediated by prostaglandin E receptor-stimulated phosphoinositide metabolism. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 19: 176-9. PMID 2546380  0.56
1989 Sugama K, Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. Biochimica Et Biophysica Acta. 1011: 75-80. PMID 2538150 DOI: 10.1016/0167-4889(89)90081-5  0.56
1989 Negishi M, Ito S, Hayaishi O. Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner. The Journal of Biological Chemistry. 264: 3916-23. PMID 2537296  0.56
1989 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Hayashi H, Kagamiyama H, Nakanishi S, Hayaishi O. Cloning, nucleotide sequence and gene expression of bovine lung prostaglandin F synthetase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 19: 462-5. PMID 2526518  0.56
1989 Ito S, Narumiya S, Hayaishi O. Prostaglandin D2: a biochemical perspective. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 37: 219-34. PMID 2510183 DOI: 10.1016/0952-3278(89)90033-1  0.68
1989 Urade Y, Ujihara M, Horiguchi Y, Ikai K, Hayaishi O. The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. Journal of Immunology (Baltimore, Md. : 1950). 143: 2982-9. PMID 2509561  0.56
1989 Hatanaka M, Yumoto N, Miwa N, Morii H, Tanemura M, Ueno R, Watanabe Y, Hayaishi O. Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. Journal of Neurochemistry. 53: 1450-5. PMID 2507741  0.56
1989 Carper DA, Wistow G, Nishimura C, Graham C, Watanabe K, Fujii Y, Hayashi H, Hayaishi O. A superfamily of NADPH-dependent reductases in eukaryotes and prokaryotes. Experimental Eye Research. 49: 377-88. PMID 2507340  0.44
1989 Goh Y, Araie M, Nakajima M, Azuma I, Hayaishi O. Effect of topical prostaglandin D2 on the aqueous humor dynamics in rabbits. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 227: 476-81. PMID 2478423 DOI: 10.1007/BF02172902  0.56
1989 Ito S, Negishi M, Hayashi H, Hayaishi O. The role and new action mechanism of prostaglandin E2 in neurotransmission Annals of the New York Academy of Sciences. 559: 453-454.  0.56
1989 Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O. Primary structure of rat brain prostaglandin D synthetase deduced from the cDNA sequence Annals of the New York Academy of Sciences. 559: 491-493.  0.56
1989 Hayashi H, Eguchi N, Urade Y, Ito S, Hayaishi O. Prostaglandin E2 administered intravenously crosses the blood-brain barrier and induces hyperthermia as a central action Annals of the New York Academy of Sciences. 559: 451-452.  0.56
1989 Watanabe Y, Langstrom B, Hamada K, Gillberg PG, Stalnacke CG, Hatanaka M, Hayashi H, Hayaishi O. Functional-site study of prostaglandins in the monkey brain using quantitative autoradiography and positron emission tomography Annals of the New York Academy of Sciences. 559: 494-496.  0.56
1988 Sugino H, Miwa T, Ueno R, Hayaishi O. Alteration in morphology and induction of glutamine synthetase in rat glioma C6BU-1 cells cultured with prostaglandin D(2)-supplemented media. Neurochemistry International. 12: 5-12. PMID 20501196  0.4
1988 Ohishi K, Ueno R, Nishino S, Sakai T, Hayaishi O. Increased level of salivary prostaglandins in patients with major depression. Biological Psychiatry. 23: 326-34. PMID 3422573  0.4
1988 Hayaishi O, Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S. Prostaglandin F synthetase, a dual function enzyme. Progress in Clinical and Biological Research. 274: 577-87. PMID 3406039  0.44
1988 Naito K, Osama H, Ueno R, Hayaishi O, Honda K, Inoué S. Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats. Brain Research. 453: 329-36. PMID 3401770  0.4
1988 Ito S, Tanaka T, Hayashi H, Hayaishi O. Problems in production of prostaglandin D2-specific antibody. Eicosanoids. 1: 111-6. PMID 3273218  0.56
1988 Eguchi N, Hayashi H, Urade Y, Ito S, Hayaishi O. Central action of prostaglandin E2 and its methyl ester in the induction of hyperthermia after their systemic administration in urethane-anesthetized rats. The Journal of Pharmacology and Experimental Therapeutics. 247: 671-9. PMID 3183962  0.56
1988 Onoe H, Ueno R, Fujita I, Nishino H, Oomura Y, Hayaishi O. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proceedings of the National Academy of Sciences of the United States of America. 85: 4082-6. PMID 3163802  0.56
1988 Matsumura H, Goh Y, Ueno R, Sakai T, Hayaishi O. Awaking effect of PGE2 microinjected into the preoptic area of rats. Brain Research. 444: 265-72. PMID 3162820  0.4
1988 Ujihara M, Urade Y, Eguchi N, Hayashi H, Ikai K, Hayaishi O. Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. Archives of Biochemistry and Biophysics. 260: 521-31. PMID 3124755  0.32
1988 Yamamoto K, Miwa T, Ueno R, Hayaishi O. Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. Biochemical and Biophysical Research Communications. 156: 882-8. PMID 3056405  0.4
1988 Hirata Y, Hayashi H, Ito S, Kikawa Y, Ishibashi M, Sudo M, Miyazaki H, Fukushima M, Narumiya S, Hayaishi O. Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. The Journal of Biological Chemistry. 263: 16619-25. PMID 3053696  0.68
1988 Negishi M, Ito S, Yokohama H, Hayashi H, Katada T, Ui M, Hayaishi O. Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. The Journal of Biological Chemistry. 263: 6893-900. PMID 2896200  0.56
1988 Yokohama H, Tanaka T, Ito S, Negishi M, Hayashi H, Hayaishi O. Prostaglandin E receptor enhancement of catecholamine release may be mediated by phosphoinositide metabolism in bovine adrenal chromaffin cells. The Journal of Biological Chemistry. 263: 1119-22. PMID 2891706  0.56
1988 Yokohama H, Negishi M, Sugama K, Hayashi H, Ito S, Hayaishi O. Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells. The Biochemical Journal. 255: 957-62. PMID 2850804  0.56
1988 Miwa N, Sugino H, Ueno R, Hayaishi O. Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. Journal of Neurochemistry. 50: 1418-24. PMID 2834513  0.4
1988 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S, Hayaishi O. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proceedings of the National Academy of Sciences of the United States of America. 85: 11-5. PMID 2829166  0.44
1988 Suzuki S, Watanabe Y, Tsubokura S, Kagamiyama H, Hayaishi O. Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase. Brain Research. 446: 1-10. PMID 2453255  0.44
1987 Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells. Biochemical and Biophysical Research Communications. 144: 907-14. PMID 3579947  0.56
1987 Hayashi H, Ito S, Tanaka T, Negishi M, Kawabe H, Yokohama H, Watanabe K, Hayaishi O. Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. Prostaglandins. 33: 517-30. PMID 3474704  0.56
1987 Hayashi H, Ito S, Watanabe K, Negishi M, Shintani T, Hayaishi O. Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. Biochimica Et Biophysica Acta. 917: 356-64. PMID 3467796  0.56
1987 Suzuki F, Hayashi H, Ito S, Hayaishi O. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochimica Et Biophysica Acta. 917: 224-30. PMID 3467795  0.56
1987 Takai K, Hayaishi O. Purification and properties of tryptophan side chain oxidase types I and II from Pseudomonas. Methods in Enzymology. 142: 195-217. PMID 3037258  0.44
1987 Hayaishi O, Ueno R, Onoe H, Osama H, Fujita I, Nishino H, Oomura Y. Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 946-8. PMID 2960208  0.56
1987 Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 44-6. PMID 2959094  0.44
1987 Ueno R, Kuno S, Hayaishi O. Possible pathogenesis of acquired immune deficiency syndrome in homosexual males: an unexpected action of seminal prostaglandin E2 on AIDS-virus infection. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 151-4. PMID 2959040  0.64
1987 Negishi M, Ito S, Tanaka T, Yokohama H, Hayashi H, Katada T, Ui M, Hayaishi O. Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein. The Journal of Biological Chemistry. 262: 12077-84. PMID 2887564  0.56
1987 Kawabe H, Hayashi H, Hayaishi O. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. Biochemical and Biophysical Research Communications. 143: 467-74. PMID 2436614  0.32
1986 Park SW, Ueno R, Hayaishi O. Prostaglandin synthesizing enzyme activities of hepatocytes and non-hepatocytes in rat liver as a function of age. Biochemistry International. 13: 827-34. PMID 3814160  0.4
1986 Hatakeyama K, Nemoto Y, Ueda K, Hayaishi O. Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose). The Journal of Biological Chemistry. 261: 14902-11. PMID 3771556  0.36
1986 Hiroshima O, Hayashi H, Ito S, Hayaishi O. Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. Prostaglandins. 32: 63-80. PMID 3532208  0.56
1986 Suzuki F, Hayashi H, Hayaishi O. Transport of prostaglandin D2 into brain. Brain Research. 385: 321-8. PMID 3465420  0.32
1986 Horiguchi S, Ueno R, Hyodo M, Hayaishi O. Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. European Journal of Pharmacology. 122: 173-9. PMID 3458588  0.4
1986 Kuno S, Ueno R, Hayaishi O. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. Proceedings of the National Academy of Sciences of the United States of America. 83: 2682-3. PMID 3458226  0.64
1986 Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Proceedings of the National Academy of Sciences of the United States of America. 83: 1583-7. PMID 3456602  0.44
1986 Yumoto N, Watanabe Y, Watanabe K, Watanabe Y, Hayaishi O. Solubilization and characterization of prostaglandin E2 binding protein from porcine cerebral cortex. Journal of Neurochemistry. 46: 125-32. PMID 3455668  0.44
1986 Kuno S, Ueno R, Hayaishi O, Nakashima H, Harada S, Yamamoto N. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83: 3487-90. PMID 3010301  0.64
1986 Yasui H, Takai K, Yoshida R, Hayaishi O. Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 83: 6622-6. PMID 2428037  0.44
1985 Hayaishi O, Ueda K, Oka J, Komura H, Nakanishi K. 3-Deoxy-D-glycero-pentos-2-ulose, a novel pentose derived from poly(ADP-ribosyl) histones. Current Topics in Cellular Regulation. 27: 253-64. PMID 4092491  0.36
1985 Tanaka T, Ito S, Hiroshima O, Hayashi H, Hayaishi O. Rat monoclonal antibody specific for prostaglandin E structure. Biochimica Et Biophysica Acta. 836: 125-33. PMID 3927979  0.56
1985 Ueda K, Hayaishi O. ADP-ribosylation. Annual Review of Biochemistry. 54: 73-100. PMID 3927821 DOI: 10.1146/annurev.bi.54.070185.000445  0.36
1985 Ueno R, Osama H, Urade Y, Hayaishi O. Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. Journal of Neurochemistry. 45: 483-9. PMID 3925085  0.4
1985 Park SW, Ueno R, Hayaishi O. Developmental changes in the activities of prostaglandin synthesizing enzymes in the digestive and immune systems of rat. Biochemistry International. 10: 873-9. PMID 3862409  0.4
1985 Watanabe K, Yoshida R, Shimizu T, Hayaishi O. Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. The Journal of Biological Chemistry. 260: 7035-41. PMID 3858278  0.48
1985 Watanabe Y, Tokumoto H, Yamashita A, Narumiya S, Mizuno N, Hayaishi O. Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. Brain Research. 342: 110-6. PMID 2994820  0.68
1985 Ueno R, Hayaishi O, Inoué S, Nakayama T. Prostaglandin D2: a cerebral sleep-regulating substance in rats. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 581-3. PMID 2936173  0.4
1985 Watanabe K, Yoshida R, Shimizu T, Hayaishi O. Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 151-3. PMID 2936081  0.48
1984 Oka J, Ueda K, Hayaishi O, Komura H, Nakanishi K. ADP-ribosyl protein lyase. Purification, properties, and identification of the product. The Journal of Biological Chemistry. 259: 986-95. PMID 6693407  0.36
1984 Inoué S, Honda K, Komoda Y, Uchizono K, Ueno R, Hayaishi O. Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. Neuroscience Letters. 49: 207-11. PMID 6593603  0.4
1984 Inoué S, Honda K, Komoda Y, Uchizono K, Ueno R, Hayaishi O. Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. Proceedings of the National Academy of Sciences of the United States of America. 81: 6240-4. PMID 6592612  0.4
1984 Kikawa Y, Narumiya S, Fukushima M, Wakatsuka H, Hayaishi O. 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. Proceedings of the National Academy of Sciences of the United States of America. 81: 1317-21. PMID 6584883  0.68
1984 Ogorochi T, Narumiya S, Mizuno N, Yamashita K, Miyazaki H, Hayaishi O. Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. Journal of Neurochemistry. 43: 71-82. PMID 6427411  0.68
1984 Ueda K, Hayaishi O. Evidence for poly(ADP-ribosyl) derivatives of carboxylates in histone. Methods in Enzymology. 106: 450-61. PMID 6387381 DOI: 10.1016/0076-6879(84)06049-3  0.36
1984 Ohashi Y, Ueda K, Hayaishi O, Ikai K, Niwa O. Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 7132-6. PMID 6095269  0.36
1984 Ueda K, Zhang J, Hayaishi O. Poly(ADP-ribose) synthetase. Methods in Enzymology. 106: 500-4. PMID 6092836 DOI: 10.1016/0076-6879(84)06054-7  0.36
1983 Zavala F, Takai K, Hayaishi O. Isolation and characterization of the common intermediate in dichotomous reaction catalyzed by tryptophan side chain oxidase. The Journal of Biological Chemistry. 258: 344-51. PMID 6848506  0.44
1983 Ueda K, Ohashi Y, Hatakeyama K, Hayaishi O. Inhibition of DNA ligase activity by histones and its reversal by poly(ADP-ribose). Princess Takamatsu Symposia. 13: 175-82. PMID 6654829  0.36
1983 Ueno R, Honda K, Inoué S, Hayaishi O. Prostaglandin D2, a cerebral sleep-inducing substance in rats. Proceedings of the National Academy of Sciences of the United States of America. 80: 1735-7. PMID 6572936  0.4
1983 Osama H, Narumiya S, Hayaishi O, Iinuma H, Takeuchi T, Umezawa H. Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. Biochimica Et Biophysica Acta. 752: 251-8. PMID 6407532  0.68
1983 Ohashi Y, Ueda K, Kawaichi M, Hayaishi O. Activation of DNA ligase by poly(ADP-ribose) in chromatin. Proceedings of the National Academy of Sciences of the United States of America. 80: 3604-7. PMID 6407017  0.36
1983 Hirai K, Ueda K, Hayaishi O. Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. Cancer Research. 43: 3441-6. PMID 6406058  0.36
1983 Kawaichi M, Oka J, Zhang J, Ueda K, Hayaishi O. Properties of poly(ADP-ribose) synthetase and ADP-ribosyl histone splitting enzyme. Princess Takamatsu Symposia. 13: 121-8. PMID 6317633  0.36
1982 Shimizu T, Yamamoto S, Hayaishi O. Purification of PGH-PGD isomerase from rat brain. Methods in Enzymology. 86: 73-7. PMID 7132774  0.48
1982 Shimizu T, Watanabe K, Tokumoto H, Hayaishi O. Isolation of NADP+-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain. Methods in Enzymology. 86: 147-52. PMID 7132752  0.48
1982 Watanabe T, Shimizu T, Narumiya S, Hayaishi O. [Metabolism and action of prostaglandin D2 in blood platelets]. Rinsho Byori. the Japanese Journal of Clinical Pathology. 9-20. PMID 7131811  0.68
1982 Ueno R, Narumiya S, Ogorochi T, Nakayama T, Ishikawa Y, Hayaishi O. Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 79: 6093-7. PMID 6964402  0.68
1982 Fukushima M, Kato T, Ota K, Arai Y, Narumiya S, Hayaishi O. 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. Biochemical and Biophysical Research Communications. 109: 626-33. PMID 6961920  0.68
1982 Ueno R, Ishikawa Y, Nakayama T, Hayaishi O. Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. Biochemical and Biophysical Research Communications. 109: 576-82. PMID 6960896  0.4
1982 Narumiya S, Ogorochi T, Nakao K, Hayaishi O. Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. Life Sciences. 31: 2093-103. PMID 6960222  0.68
1982 Tokumoto H, Watanabe K, Fukushima D, Shimizu T, Hayaishi O. An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. The Journal of Biological Chemistry. 257: 13576-80. PMID 6958674  0.48
1982 Watanabe T, Shimizu T, Narumiya S, Hayaishi O. NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. Archives of Biochemistry and Biophysics. 216: 372-9. PMID 6954879  0.68
1982 Fukushima M, Kato T, Ueda R, Ota K, Narumiya S, Hayaishi O. Prostaglandin D2, a potential antineoplastic agent. Biochemical and Biophysical Research Communications. 105: 956-64. PMID 6953969  0.68
1982 Kinoshita F, Nakai Y, Katakami H, Imura H, Shimizu T, Hayaishi O. Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. Endocrinology. 110: 2207-9. PMID 6951712 DOI: 10.1210/endo-110-6-2207  0.48
1982 Watanabe T, Narumiya S, Shimizu T, Hayaishi O. Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. The Journal of Biological Chemistry. 257: 14847-53. PMID 6816798  0.68
1982 Ueno R, Shimizu T, Kondo K, Hayaishi O. Activation mechanism of prostaglandin endoperoxide synthetase by hemoproteins. The Journal of Biological Chemistry. 257: 5584-8. PMID 6802818  0.48
1982 Shimizu T, Yamashita A, Hayaishi O. Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. The Journal of Biological Chemistry. 257: 13570-5. PMID 6292197  0.48
1982 Ueda K, Ogata N, Kawaichi M, Inada S, Hayaishi O. ADP-ribosylation reactions. Current Topics in Cellular Regulation. 21: 175-87. PMID 6291854  0.36
1981 Kawaichi M, Oka J, Ueda K, Hayaishi O. A new method for oligo (ADP-ribose) fractionation according to chain length. Biochemical and Biophysical Research Communications. 101: 672-9. PMID 7306102  0.36
1981 Ito S, Takai K, Tokuyama T, Hayaishi O. Enzymatic modification of tryptophan residues by tryptophan side chain oxidase I and II from Pseudomonas. The Journal of Biological Chemistry. 256: 7834-43. PMID 7263628  0.56
1981 Kondo K, Shimizu T, Hayaishi O. Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye. Biochemical and Biophysical Research Communications. 98: 648-55. PMID 7225118 DOI: 10.1016/0006-291X(81)91163-3  0.48
1981 Shimizu T, Kondo K, Hayaishi O. Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. Archives of Biochemistry and Biophysics. 206: 271-6. PMID 7224637 DOI: 10.1016/0003-9861(81)90091-6  0.48
1981 Ogata N, Ueda K, Hayaishi O. Synthesis of [ribose (NMN)-14C]nicotinamide adenine dinucleotide from D-[14C]glucose. Analytical Biochemistry. 115: 58-60. PMID 7030128  0.36
1981 Kawaichi M, Ueda K, Hayaishi O. Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase. The Journal of Biological Chemistry. 256: 9483-9. PMID 6270088  0.36
1981 Ogata N, Ueda K, Kawaichi M, Hayaishi O. Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei. The Journal of Biological Chemistry. 256: 4135-7. PMID 6260786  0.36
1980 Ogata N, Ueda K, Hayaishi O. ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. The Journal of Biological Chemistry. 255: 7610-5. PMID 7400135  0.36
1980 Ogata N, Ueda K, Kagamiyama H, Hayaishi O. ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites. The Journal of Biological Chemistry. 255: 7616-20. PMID 6772638  0.44
1979 Ushiro H, Takai K, Narumiya S, Ito S, Hayaishi O. Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase. The Journal of Biological Chemistry. 254: 11794-7. PMID 500674  0.68
1979 Narumiya S, Takai K, Tokuyama T, Noda Y, Ushiro H, Hayaishi O. A new metabolic pathway of tryptophan initiated by tryptophan side chain oxidase. The Journal of Biological Chemistry. 254: 7007-15. PMID 110802  0.68
1978 Ushiro H, Takai K, Noda Y, Narumiya S, Tokuyama T, Hayaishi O. Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol. The Journal of Biological Chemistry. 253: 9002-8. PMID 721824  0.68
1978 Noda Y, Takai K, Tokuyama T, Narumiya S, Ushiro H, Hayaishi O. Tryptophan side chain oxidase from Pseudomonas. pH-dependent formation of alpha,beta-didehydro, beta-hydroxy, and beta-keto derivatives of N-acetyltryptophanamide. The Journal of Biological Chemistry. 253: 4819-22. PMID 27505  0.68
1977 Noda Y, Takai K, Tokuyama T, Narumiya S, Ushiro H, Hayaishi O. Enzymatic oxidation of acetyltryptophanamide- and tryptophan-containing peptides. Formation of dehydrotryptophan. The Journal of Biological Chemistry. 252: 4413-5. PMID 863932  0.68
1971 Honjo T, Nishizuka Y, Kato I, Hayaishi O. Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. The Journal of Biological Chemistry. 246: 4251-60. PMID 4326212  1
1971 Nishizuka Y, Hayaishi O. [120] Picolinic car{ballot box}ylase in reference to NAD biosynthesis Methods in Enzymology. 18: 162-175. DOI: 10.1016/S0076-6879(71)18077-9  1
1971 Nishizuka Y, Hayaishi O. [116] Mammalian pyridine ribonucleoside phosphokinase Methods in Enzymology. 18: 141-144. DOI: 10.1016/S0076-6879(71)18073-1  1
1970 Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O. Enzymic studies on the biosynthesis of serotonin in mammalian brain. The Journal of Biological Chemistry. 245: 1699-709. PMID 5309585  1
1970 Nishizuka Y, Ichiyama A, Hayaishi O. [58] Metabolism of the benzene ring of tryptophan (mammals) Methods in Enzymology. 17: 463-491. DOI: 10.1016/0076-6879(71)17228-X  0.56
1969 Nishizuka Y, Ueda K, Yoshihara K, Yamamura H, Takeda M, Hayaishi O. Enzymic adenosine diphosphoribosylation of nuclear proteins. Cold Spring Harbor Symposia On Quantitative Biology. 34: 781-6. PMID 4314921  1
1969 Honjo T, Nishizuka Y, Hayaishi O. Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. Cold Spring Harbor Symposia On Quantitative Biology. 34: 603-8. PMID 4314916  1
1968 Nakazawa K, Ueda K, Honjo T, Yoshihara K, Nishizuka Y, Hayaishi O. Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. Biochemical and Biophysical Research Communications. 32: 143-9. PMID 5672131  1
1968 Ueda K, Reeder RH, Honjo T, Nishizuka Y, Hayaishi O. Poly adenosine diphosphate ribose synthesis associated with chromatin. Biochemical and Biophysical Research Communications. 31: 379-85. PMID 5653649  1
1968 Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O. Tryptophan-5-hydroxylase in mammalian brain. Advances in Pharmacology. 6: 5-17. PMID 5302021  1
1968 Deguchi T, Ichiyama A, Nishizuka Y, Hayaishi O. Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain. Biochimica Et Biophysica Acta. 158: 382-93. PMID 4298234  1
1968 Nishizuka Y, Ueda K, Honjo T, Hayaishi O. Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. The Journal of Biological Chemistry. 243: 3765-7. PMID 4298073  1
1968 Honjo T, Nishizuka Y, Hayaishi O. Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. The Journal of Biological Chemistry. 243: 3553-5. PMID 4297784  1
1967 Ohtsu E, Ichiyama A, Nishizuka Y, Hayaishi O. Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms. Biochemical and Biophysical Research Communications. 29: 635-41. PMID 4294854  1
1967 Reeder RH, Ueda K, Honjo T, Nishizuka Y, Hayaishi O. Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. The Journal of Biological Chemistry. 242: 3172-9. PMID 4291073  1
1967 Nishizuka Y, Ueda K, Nakazawa K, Hayaishi O. Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei. The Journal of Biological Chemistry. 242: 3164-71. PMID 4291072  1
1966 Nishizuka Y, Hayaishi O, Morris HP. Cancer research: u. S.-Japan cooperative science program. Science (New York, N.Y.). 152: 1524-6. PMID 17788034 DOI: 10.1126/science.152.3728.1524  1
1966 Honjo T, Nakamura S, Nishizuka Y, Hayaishi O. Stoichiometric utilization of adenosine 5'-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl-1-pyrophosphate. Biochemical and Biophysical Research Communications. 25: 199-204. PMID 4291351  1
1965 IKEDA M, TSUJI H, NAKAMURA S, ICHIYAMA A, NISHIZUKA Y, HAYAISHI O. STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS. The Journal of Biological Chemistry. 240: 1395-401. PMID 14284754  1
1965 ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O, SENOH S. STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID. The Journal of Biological Chemistry. 240: 740-9. PMID 14275130  1
1965 NISHIZUKA Y, ICHIYAMA A, GHOLSON RK, HAYAISHI O. STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID. The Journal of Biological Chemistry. 240: 733-9. PMID 14275129  1
1964 NAKAMURA S, NISHIZUKA Y, HAYAISHI O. REGULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE BIOSYNTHESIS BY ADENOSINE TRIPHOSPHATE. The Journal of Biological Chemistry. 239: PC2717-9. PMID 14235558  1
1964 HONJO T, IKEDA M, ANDREOLI AJ, NISHIZUKA Y, HAYAISHI O. ENZYMIC PREPARATION OF NICOTINATE ADENINE DINUCLEOTIDE (DEAMIDO-NAD). Biochimica Et Biophysica Acta. 89: 549-52. PMID 14209340  1
1963 NISHIZUKA Y, HAYAISHI O. STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. I. ENZYMIC SYNTHESIS OF NIACIN RIBONUCLEOTIDES FROM 3-HYDROXYANTHRANILIC ACID IN MAMMALIAN TISSUES. The Journal of Biological Chemistry. 238: 3369-77. PMID 14085389  1
1963 ANDREOLI AJ, IKEDA M, NISHIZUKA Y, HAYAISHI O. Quinolinic acid: a precursor to nicotinamide adenine dinucleotide in Escherichia coli. Biochemical and Biophysical Research Communications. 12: 92-7. PMID 14013029  1
1963 TAKESHITA M, NISHIZUKA Y, HAYAISHI O. Studies on beta-(pyrazolyl-n)-L-alanine. The Journal of Biological Chemistry. 238: 660-5. PMID 13984678  1
1963 NISHIZUKA Y, HAYAISHI O. Enzymic synthesis of niacin nucleotides from 3-hydroxyanthranilic acid in mammalian liver. The Journal of Biological Chemistry. 238: 483-5. PMID 13938817  1
1962 NISHIZUKA Y, ICHIYAMA A, NAKAMURA S, HAYAISHI O. A new metabolic pathway of catechol. The Journal of Biological Chemistry. 237: PC268-PC270. PMID 14480006  1
1962 NISHIZUKA Y, HAYAISHI O. Enzymic formation of lactobionic acid from lactose. The Journal of Biological Chemistry. 237: 2721-8. PMID 14480005  1
1962 GHOLSON RK, NISHIZUKA Y, ICHIYAMA A, KAWAI H, NAKAMURA S, HAYAISHI O. New intermediates in the catabolism of tryptophan in mammalian liver. The Journal of Biological Chemistry. 237: 2043-5. PMID 13898215  1
1962 Hayaishi O, Nishizuka Y. [94c] β-Alanine-α-alanine transaminase (Pseudomonas). β-Alanine + pyruvic acid ⇄ Malonic semialdehyde + α-alanine Methods in Enzymology. 5: 698-702. DOI: 10.1016/S0076-6879(62)05297-0  1
1961 HAYAISHI O, NISHIZUKA Y. [Role of fats in oxidation in living organisms, with special reference to coenzyme O]. [Kagaku] [Science]. 31: 69-76. PMID 24546602  1
1961 NUMA S, ISHIMURA Y, NISHIZUKA Y, HAYAISHI O. beta-Hydroxybutyryl-CoA, an intermediate in glutarate catabolism. Biochemical and Biophysical Research Communications. 6: 38-43. PMID 14480702  1
1961 TAKESHITA M, NISHIZUKA Y, HAYAISHI O. Enzymic degradation of beta-(pyrazolyl-N)-L-alanine. Biochimica Et Biophysica Acta. 48: 409-10. PMID 13774970  1
1961 HAYAISHI O, NISHIZUKA Y, TATIBANA M, TAKESHITA M, KUNO S. Enzymatic studies on the metabolism of beta-alanine. The Journal of Biological Chemistry. 236: 781-90. PMID 13712439  1
1960 NISHIZUKA Y, KUNO S, HAYAISHI O. Lactose dehydrogenase, a new flavoprotein. The Journal of Biological Chemistry. 235: PC13-4. PMID 14427323  1
1960 NISHIZUKA Y, KUNO S, HAYAISHI O. Enzymic formation of acetyl-CoA and carbon dioxide from glutaryl-CoA. Biochimica Et Biophysica Acta. 43: 357-60. PMID 13729237  1
1959 NISHIZUKA Y, TAKESHITA M, KUNO S, HAYAISHI O. beta-Alanine-alpha-alanine transaminase of Pseudomonas. Biochimica Et Biophysica Acta. 33: 591-3. PMID 13670947  1
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