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Osamu Hayaishi - Publications

Affiliations: 
1954-1958 NIH (NIAMDD) 
 1958- Kyoto University 
Area:
Biochemistry
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Year Citation  Score
2014 Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D(2) is crucial for seizure suppression and postictal sleep. Experimental Neurology. 253: 82-90. PMID 24333565 DOI: 10.1016/J.Expneurol.2013.12.002  0.366
2013 Kallweit U, Aritake K, Bassetti CL, Blumenthal S, Hayaishi O, Linnebank M, Baumann CR, Urade Y. Elevated CSF histamine levels in multiple sclerosis patients. Fluids and Barriers of the Cns. 10: 19. PMID 23659456 DOI: 10.1186/2045-8118-10-19  0.305
2011 Urade Y, Hayaishi O. Prostaglandin D2 and sleep/wake regulation. Sleep Medicine Reviews. 15: 411-8. PMID 22024172 DOI: 10.1016/j.smrv.2011.08.003  0.421
2011 Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10067-75. PMID 21734299 DOI: 10.1523/Jneurosci.6730-10.2011  0.245
2011 Huang ZL, Urade Y, Hayaishi O. The role of adenosine in the regulation of sleep. Current Topics in Medicinal Chemistry. 11: 1047-57. PMID 21401496 DOI: 10.2174/156802611795347654  0.405
2011 Huang ZL, Urade Y, Hayaishi O. Key roles of the histaminergic system in sleep-wake regulation Sleep and Biological Rhythms. 9: 34-37. DOI: 10.1111/J.1479-8425.2010.00471.X  0.421
2011 Hayaishi O. Humoral mechanisms of sleep-wake regulation: Historical review of prostaglandin D 2 and related substances Sleep and Biological Rhythms. 9: 3-9. DOI: 10.1111/j.1479-8425.2010.00448.x  0.399
2010 Urade Y, Hayaishi O. Crucial role of prostaglandin D2 and adenosine in sleep regulation: Experimental evidence from pharmacological approaches to gene-knockout mice Future Neurology. 5: 363-376. DOI: 10.2217/fnl.10.18  0.429
2010 HAYAISHI O, TAKIKAWA S, YOSHIDA R. ChemInform Abstract: Indoleamine 2,3-Dioxygenase: Properties and Functions of a Superoxide Utilizing Enzyme Cheminform. 22: no-no. DOI: 10.1002/chin.199139323  0.288
2009 Kumasaka T, Aritake K, Ago H, Irikura D, Tsurumura T, Yamamoto M, Miyano M, Urade Y, Hayaishi O. Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase. The Journal of Biological Chemistry. 284: 22344-52. PMID 19546224 DOI: 10.1074/jbc.M109.018341  0.285
2009 Lazarus M, Higashi T, Enomoto T, Yasuda H, Urade Y, Hayaishi O. Adeno-associated viral (AAV) vectors carrying shRNA for the focal deletion of sleep-active adenosine A2A receptors Neuroscience Research. 65: S57. DOI: 10.1016/j.neures.2009.09.146  0.385
2008 Oishi Y, Huang ZL, Fredholm BB, Urade Y, Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 105: 19992-7. PMID 19066225 DOI: 10.1073/Pnas.0810926105  0.407
2008 Hayaishi O. From oxygenase to sleep. The Journal of Biological Chemistry. 283: 19165-75. PMID 18390546 DOI: 10.1074/jbc.X800002200  0.382
2008 Urade Y, Hayaishi O. Prostaglandin D (2) and sleep/wake regulation Sleep Medicine Reviews. 15: 266-278. DOI: 10.3109/9780203091715-28  0.405
2008 Hayaishi O, Urade Y. Prostaglandins and the regulation of sleep and wakefulness Neurochemistry of Sleep and Wakefulness. 363-386. DOI: 10.1017/CBO9780511541674.014  0.287
2007 Huang ZL, Urade Y, Hayaishi O. Prostaglandins and adenosine in the regulation of sleep and wakefulness. Current Opinion in Pharmacology. 7: 33-8. PMID 17129762 DOI: 10.1016/J.Coph.2006.09.004  0.32
2007 Urade Y, Qu W, Huang Z, Nambu F, Eguchi N, Hayaishi O. L0033 Antagonism of prostaglandin D2 receptor inhibits physiological sleep in rats Sleep Medicine. 8: S106. DOI: 10.1016/S1389-9457(07)70401-X  0.328
2007 Huang Z, Qu W, Eguchi N, Urade Y, Hayaishi O. L0032 Adenosine A2A receptor deficiency attenuates somnogenic effect of prostaglandin D2 Sleep Medicine. 8: S105-S106. DOI: 10.1016/S1389-9457(07)70400-8  0.266
2007 Qu W, Huang Z, Eguchi N, Urade Y, Hayaishi O. L0031 Lipocalin-type prostaglandin D synthase is the key enzyme for production of prostaglandin D2 involved in physiological sleep Sleep Medicine. 8: S105. DOI: 10.1016/S1389-9457(07)70399-4  0.348
2007 Hayaishi O. Chapter 1 Odyssey of a Biochemist Comprehensive Biochemistry. 45: 1-36. DOI: 10.1016/S0069-8032(07)45001-X  0.419
2007 Hayaishi O, Takikawa O, Yoshida R. Indoleamine 2,3‐Dioxygenase: Properties and Functions of a Superoxide Utilizing Enzyme Progress in Inorganic Chemistry. 38: 75-95. DOI: 10.1002/9780470166390.Ch2  0.388
2006 Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi N, Nambu F, Narumiya S, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proceedings of the National Academy of Sciences of the United States of America. 103: 17949-54. PMID 17093043 DOI: 10.1073/pnas.0608581103  0.486
2006 Hayaishi O. Memoirs of a biochemist. Iubmb Life. 58: 242-5. PMID 16754304 DOI: 10.1080/15216540600702271  0.185
2006 Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y, Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 4687-92. PMID 16537376 DOI: 10.1073/Pnas.0600451103  0.272
2005 Hayaishi O. An odyssey with oxygen. Biochemical and Biophysical Research Communications. 338: 2-6. PMID 16185652 DOI: 10.1016/j.bbrc.2005.09.019  0.183
2005 Gallopin T, Luppi PH, Cauli B, Urade Y, Rossier J, Hayaishi O, Lambolez B, Fort P. The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus. Neuroscience. 134: 1377-90. PMID 16039802 DOI: 10.1016/J.Neuroscience.2005.05.045  0.408
2005 Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nature Neuroscience. 8: 858-9. PMID 15965471 DOI: 10.1038/Nn1491  0.238
2005 Hong ZY, Huang ZL, Qu WM, Eguchi N, Urade Y, Hayaishi O. An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. Journal of Neurochemistry. 92: 1542-9. PMID 15748171 DOI: 10.1111/J.1471-4159.2004.02991.X  0.391
2005 Hayaishi O. "Fifty years of oxygen activation". Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 1-2. PMID 15592943 DOI: 10.1007/s00775-004-0615-3  0.203
2005 Hayaishi O. IUB(MB) 50th Anniversary Iubmb Life. 57: 213-214. DOI: 10.1080/15216540500091825  0.289
2005 Hayaishi O, Coon MJ, Estabrook RW, Que L, Yamamoto S. Biochemical and Biophysical Research Communications: Preface Biochemical and Biophysical Research Communications. 338: 1. DOI: 10.1016/J.Bbrc.2005.10.017  0.291
2004 Hayaishi O, Urade Y, Eguchi N, Huang ZL. Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. Archives Italiennes De Biologie. 142: 533-9. PMID 15493554 DOI: 10.4449/Aib.V142I4.424  0.413
2004 Hayaishi O, Huang ZL. Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission. Drug News & Perspectives. 17: 105-9. PMID 15098064 DOI: 10.1358/Dnp.2004.17.2.829043  0.393
2004 Urade Y, Eguchi N, Aritake K, Hayaishi O. [Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 123: 5-13. PMID 14695453 DOI: 10.1254/fpj.123.5  0.307
2004 Hayaishi O. Recent progress in sleep research: Medical and social impact Sleep and Biological Rhythms. 2: S61. DOI: 10.1111/j.1479-8425.2004.00120.x  0.355
2004 Sakata M, Eguchi N, Qu WM, Huang ZL, Chen JF, Schwarzschild MA, Urade Y, Hayaishi O. Lack of rebound of non-rapid eye movement sleep after sleep deprivation in adenosine A2A receptor knockout mice Sleep and Biological Rhythms. 2: S56. DOI: 10.1111/J.1479-8425.2004.00115.X  0.385
2004 Qu WM, Huang ZL, Mochizuki T, Eguchi N, Chen JF, Schwarzschild MA, Fink SJ, Urade Y, Hayaishi O. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 Sleep and Biological Rhythms. 2: S55. DOI: 10.1111/J.1479-8425.2004.00114.X  0.371
2004 Huang ZL, Qu WM, Eguchi N, Chu M, Okada T, Sato Y, Sakata M, Mochizuki T, Urade Y, Hayaishi O. Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E2 and D2 Sleep and Biological Rhythms. 2: S21-S22. DOI: 10.1111/j.1479-8425.2004.00094.x  0.316
2004 Eguchi N, Qu WM, Huang ZL, Sakata M, Narumiya S, Chen JF, Urade Y, Hayaishi O. Molecular mechanism of prostaglandin D2-mediated non-REM sleep homeostasis studied by gene-knockout mice Sleep and Biological Rhythms. 2: S17-S18. DOI: 10.1111/j.1479-8425.2004.00092.x  0.527
2004 Hayaishi O. Recent progress in sleep research - Biological, clinical and social impact Sleep and Biological Rhythms. 2: S2. DOI: 10.1111/j.1479-8425.2004.00083.x  0.359
2004 Hayaishi O, Urade Y. Sleep and Biological Rhythms: Foreword Sleep and Biological Rhythms. 2: S1. DOI: 10.1111/j.1479-8425.2004.00082.x  0.278
2003 Hayaishi O. Musajo Memorial Award Lecture: "Metabolism to function--an odyssey with tryptophan". Advances in Experimental Medicine and Biology. 527: 1-11. PMID 15206711  0.196
2003 Urade Y, Eguchi N, Qu WM, Sakata M, Huang ZL, Chen JF, Schwarzschild MA, Fink JS, Hayaishi O. Sleep regulation in adenosine A2A receptor-deficient mice. Neurology. 61: S94-6. PMID 14663019 DOI: 10.1212/01.Wnl.0000095222.41066.5E  0.415
2003 Okada T, Mochizuki T, Huang ZL, Eguchi N, Sugita Y, Urade Y, Hayaishi O. Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep. Biochemical and Biophysical Research Communications. 312: 29-34. PMID 14630012 DOI: 10.1016/j.bbrc.2003.09.220  0.44
2003 Huang ZL, Sato Y, Mochizuki T, Okada T, Qu WM, Yamatodani A, Urade Y, Hayaishi O. Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5975-83. PMID 12853415 DOI: 10.1523/Jneurosci.23-14-05975.2003  0.379
2003 Irikura D, Kumasaka T, Yamamoto M, Ago H, Miyano M, Kubata KB, Sakai H, Hayaishi O, Urade Y. Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. Journal of Biochemistry. 133: 29-32. PMID 12761195 DOI: 10.1093/jb/mvg006  0.38
2003 Inui T, Ohkubo T, Emi M, Irikura D, Hayaishi O, Urade Y. Characterization of the unfolding process of lipocalin-type prostaglandin D synthase. The Journal of Biological Chemistry. 278: 2845-52. PMID 12441340 DOI: 10.1074/jbc.M209934200  0.366
2003 Hayaishi O. A Tribute to Kunio Yagi Iubmb Life. 55: 635-636. DOI: 10.1080/15216540310001643936  0.289
2003 Hayaishi O. Metabolism to function an odyssey with tryptophan Advances in Experimental Medicine and Biology. 527: 1-11.  0.213
2002 Hayaishi O, Urade Y. Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 12-5. PMID 11843094 DOI: 10.1177/107385840200800105  0.403
2002 Hayaishi O. Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. Journal of Applied Physiology (Bethesda, Md. : 1985). 92: 863-8. PMID 11796702 DOI: 10.1152/japplphysiol.00766.2001  0.405
2002 Lazarus M, Kubata BK, Eguchi N, Fujitani Y, Urade Y, Hayaishi O. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Archives of Biochemistry and Biophysics. 397: 336-41. PMID 11795891 DOI: 10.1006/abbi.2001.2614  0.389
2002 Huang Z, Mochizuki T, Okada T, Hayaishi O, Urade Y. Prostaglandin E2 activates the histaminergic system in the rat brain International Congress Series. 1233: 441-445. DOI: 10.1016/S0531-5131(02)00526-5  0.273
2001 Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O. An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience. 107: 653-63. PMID 11720788 DOI: 10.1016/S0306-4522(01)00383-9  0.419
2001 Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T, Narumiya S, Urade Y, Hayaishi O. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 98: 11674-9. PMID 11562489 DOI: 10.1073/Pnas.201398898  0.539
2001 Huang ZL, Qu WM, Li WD, Mochizuki T, Eguchi N, Watanabe T, Urade Y, Hayaishi O. Arousal effect of orexin A depends on activation of the histaminergic system. Proceedings of the National Academy of Sciences of the United States of America. 98: 9965-70. PMID 11493714 DOI: 10.1073/Pnas.181330998  0.314
2000 Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. The Journal of Experimental Medicine. 192: 1327-38. PMID 11067881 DOI: 10.1084/jem.192.9.1327  0.364
2000 Urade Y, Hayaishi O. Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochimica Et Biophysica Acta. 1482: 259-71. PMID 11058767 DOI: 10.1016/S0167-4838(00)00161-8  0.44
2000 Beuckmann CT, Lazarus M, Gerashchenko D, Mizoguchi A, Nomura S, Mohri I, Uesugi A, Kaneko T, Mizuno N, Hayaishi O, Urade Y. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. The Journal of Comparative Neurology. 428: 62-78. PMID 11058225 DOI: 10.1002/1096-9861(20001204)428:1<62::AID-CNE6>3.0.CO;2-E  0.41
2000 Beuckmann CT, Fujimori K, Urade Y, Hayaishi O. Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. Neurochemical Research. 25: 733-8. PMID 10905636 DOI: 10.1023/A:1007579507804  0.436
2000 Pinzar E, Miyano M, Kanaoka Y, Urade Y, Hayaishi O. Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis. The Journal of Biological Chemistry. 275: 31239-44. PMID 10871602 DOI: 10.1074/jbc.M000750200  0.296
2000 Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. European Journal of Biochemistry / Febs. 267: 3315-22. PMID 10824118 DOI: 10.1046/j.1432-1327.2000.01362.x  0.375
2000 Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 97: 4903-7. PMID 10781097 DOI: 10.1073/pnas.090093997  0.398
2000 Gerashchenko D, Okano Y, Urade Y, Inoué S, Hayaishi O. Strong rebound of wakefulness follows prostaglandin D2- or adenosine A2a receptor agonist-induced sleep. Journal of Sleep Research. 9: 81-7. PMID 10733693 DOI: 10.1046/j.1365-2869.2000.00175.x  0.417
2000 Hayaishi O. Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355: 275-80. PMID 10724461 DOI: 10.1098/rstb.2000.0564  0.45
2000 Yamamoto S, Ueda N, Mahmud I, Yamaguchi H, Yamashita R, Yamamoto K, Ishimura K, Urade Y, Kanaoka Y, Hayaishi O. Fatty acid cyclooxygenase induction accompanied by prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. Biofactors (Oxford, England). 11: 57-61. PMID 10705961 DOI: 10.1002/Biof.5520110116  0.38
2000 Urade Y, Hayaishi O. Prostaglandin D synthase: structure and function. Vitamins and Hormones. 58: 89-120. PMID 10668396 DOI: 10.1016/S0083-6729(00)58022-4  0.455
1999 Beuckmann CT, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase (beta-trace) binds non-substrate lipophilic ligands. Advances in Experimental Medicine and Biology. 469: 55-60. PMID 10667310 DOI: 10.1007/978-1-4615-4793-8_9  0.4
1999 Urade Y, Eguchi Y, Eguchi N, Kijima Y, Matsuura Y, Oda H, Seiki K, Hayaishi O. Secretion of lipocalin-type prostaglandin D synthase (beta-trace) from human heart to plasma during coronary circulation. Advances in Experimental Medicine and Biology. 469: 49-54. PMID 10667309 DOI: 10.1007/978-1-4615-4793-8_8  0.4
1999 Yamamoto S, Ueda N, Mahmud I, Yamaguchi H, Yamashita R, Yamamoto K, Ishimura K, Urade Y, Kanaoka Y, Hayaishi O. Fatty acid cyclooxygenase induction and prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. Advances in Experimental Medicine and Biology. 469: 17-21. PMID 10667304 DOI: 10.1007/978-1-4615-4793-8_3  0.425
1999 Inui T, Ohkubo T, Urade Y, Hayaishi O. Enhancement of lipocalin-type prostaglandin D synthase enzyme activity by guanidine hydrochloride. Biochemical and Biophysical Research Communications. 266: 641-6. PMID 10603301 DOI: 10.1006/bbrc.1999.1881  0.403
1999 Hayaishi O. Prostaglandin D2 and sleep--a molecular genetic approach. Journal of Sleep Research. 8: 60-4. PMID 10389108 DOI: 10.1046/j.1365-2869.1999.00010.x  0.448
1999 Beuckmann CT, Aoyagi M, Okazaki I, Hiroike T, Toh H, Hayaishi O, Urade Y. Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. Biochemistry. 38: 8006-13. PMID 10387044 DOI: 10.1021/bi990261p  0.394
1999 Satoh S, Matsumura H, Koike N, Tokunaga Y, Maeda T, Hayaishi O. Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor agonist. The European Journal of Neuroscience. 11: 1587-97. PMID 10215911 DOI: 10.1046/j.1460-9568.1999.00569.x  0.412
1999 Urade Y, Hayaishi O. Prostaglandin D2 and sleep regulation. Biochimica Et Biophysica Acta. 1436: 606-15. PMID 9989291 DOI: 10.1016/S0005-2760(98)00163-5  0.423
1999 Eguchi N, Minami T, Shirafuji N, Kanaoka Y, Tanaka T, Nagata A, Yoshida N, Urade Y, Ito S, Hayaishi O. Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 726-30. PMID 9892701 DOI: 10.1073/pnas.96.2.726  0.356
1999 Hayaishi O. Arachidonic acid cascade - Recent progress Acta Obstetrica Et Gynaecologica Japonica. 51: 514-522.  0.245
1998 Fujitani Y, Urade Y, Hayaishi O. [Sleep-promoting substances]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 35: 811-6. PMID 10064966 DOI: 10.3143/Geriatrics.35.811  0.378
1998 Hayaishi O. [Scientific study of sleep--molecular mechanism for the regulation of sleep and wakefulness]. Masui. the Japanese Journal of Anesthesiology. 47: S11-7. PMID 9921159  0.285
1998 Kilunga Kubata B, Eguchi N, Urade Y, Yamashita K, Mitamura T, Tai K, Hayaishi O, Horii T. Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. The Journal of Experimental Medicine. 188: 1197-202. PMID 9743538 DOI: 10.1084/jem.188.6.1197  0.354
1998 Gerashchenko D, Beuckmann CT, Kanaoka Y, Eguchi N, Gordon WC, Urade Y, Bazan NG, Hayaishi O. Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes. Journal of Neurochemistry. 71: 937-45. PMID 9721719 DOI: 10.1046/J.1471-4159.1998.71030937.X  0.375
1998 Satoh S, Matsumura H, Hayaishi O. Involvement of adenosine A2A receptor in sleep promotion. European Journal of Pharmacology. 351: 155-62. PMID 9686998 DOI: 10.1016/S0014-2999(98)00302-1  0.401
1998 Scammell T, Gerashchenko D, Urade Y, Onoe H, Saper C, Hayaishi O. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proceedings of the National Academy of Sciences of the United States of America. 95: 7754-9. PMID 9636223 DOI: 10.1073/pnas.95.13.7754  0.406
1998 García-Fernández LF, Urade Y, Hayaishi O, Bernal J, Muñoz A. Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. Brain Research. Molecular Brain Research. 55: 321-30. PMID 9582446 DOI: 10.1016/S0169-328X(98)00015-1  0.386
1998 Hayaishi O. [Prostaglandins and sleep]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 56: 285-9. PMID 9503823  0.378
1998 Tokugawa Y, Kunishige I, Kubota Y, Shimoya K, Nobunaga T, Kimura T, Saji F, Murata Y, Eguchi N, Oda H, Urade Y, Hayaishi O. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biology of Reproduction. 58: 600-7. PMID 9475419 DOI: 10.1095/biolreprod58.2.600  0.381
1998 Gerashchenko DY, Beuckmann CT, Marcheselli VL, Gordon WC, Kanaoka Y, Eguchi N, Urade Y, Hayaishi O, Bazan NG. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Investigative Ophthalmology & Visual Science. 39: 198-203. PMID 9430563  0.279
1998 Kubata B, Eguchi N, Urade Y, Hayaishi O, Yamashita K, Mitamura T, Tai K, Horii T. Production and secretion of prostanoids by malaria parasite Plasmodium falciparum Parasitology International. 47: 412. DOI: 10.1016/s1383-5769(98)81218-x  0.188
1998 Eguchi N, Kuwahata Y, Kanaoka Y, Nagata A, Yoshida N, Urade Y, Hayaishi O. Sleep analysis in mice laking lipocalin-type prostaglandin D synthase Neuroscience Research. 31. DOI: 10.1016/S0168-0102(98)82318-3  0.397
1998 Gerashchenko D, Scammell T, Onoe H, Urade Y, Saper C, Hayaishi O. The somnogen PGD2 induces FOS expression within unique populations of sleep-active neurons Neuroscience Research. 31: S221. DOI: 10.1016/S0168-0102(98)82317-1  0.377
1998 Satoh S, Koike N, Hayaishi O. Studies on the sleep-promoting mechanisms mediated by adenosine A2A receptors Neuroscience Research. 31. DOI: 10.1016/S0168-0102(98)82316-X  0.391
1998 Kubata BK, Eguchi N, Urade Y, Yamashita K, Horii T, Hayaishi O. Evidence of prostaglandin production by the human malaria parasite, Plasmodium falciparum South African Journal of Science. 94: 285-286.  0.194
1997 Hayaishi O. Prostaglandin D synthase, beta-trace and sleep. Advances in Experimental Medicine and Biology. 433: 347-50. PMID 9561167 DOI: 10.1007/978-1-4899-1810-9_74  0.457
1997 Suzuki T, Watanabe K, Kanaoka Y, Sato T, Hayaishi O. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochemical and Biophysical Research Communications. 241: 288-93. PMID 9425264 DOI: 10.1006/bbrc.1997.7803  0.404
1997 Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O. Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Proceedings of the National Academy of Sciences of the United States of America. 94: 14689-94. PMID 9405674 DOI: 10.1073/pnas.94.26.14689  0.361
1997 Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase in human megakaryoblastic cells. The Journal of Biological Chemistry. 272: 28263-6. PMID 9353279 DOI: 10.1074/jbc.272.45.28263  0.394
1997 Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell. 90: 1085-95. PMID 9323136 DOI: 10.1016/S0092-8674(00)80374-8  0.433
1997 García-Fernández LF, Rausell E, Urade Y, Hayaishi O, Bernal J, Muñoz A. Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain. The European Journal of Neuroscience. 9: 1566-73. PMID 9283811 DOI: 10.1111/J.1460-9568.1997.Tb01514.X  0.402
1997 Ezashi T, Sakamoto K, Miwa K, Okuda-Ashitaka E, Ito S, Hayaishi O. Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor. Gene. 190: 271-8. PMID 9197544 DOI: 10.1016/S0378-1119(97)00012-7  0.33
1997 Watanabe K, Kurihara K, Tokunaga Y, Hayaishi O. Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases. Biochemical and Biophysical Research Communications. 235: 148-52. PMID 9196052 DOI: 10.1006/bbrc.1997.6708  0.408
1997 Tanaka T, Urade Y, Kimura H, Eguchi N, Nishikawa A, Hayaishi O. Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter. The Journal of Biological Chemistry. 272: 15789-95. PMID 9188476 DOI: 10.1074/jbc.272.25.15789  0.432
1997 Ram A, Pandey HP, Matsumura H, Kasahara-Orita K, Nakajima T, Takahata R, Satoh S, Terao A, Hayaishi O. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Research. 751: 81-9. PMID 9098570 DOI: 10.1016/S0006-8993(96)01401-1  0.406
1997 Yamashima T, Sakuda K, Tohma Y, Yamashita J, Oda H, Irikura D, Eguchi N, Beuckmann CT, Kanaoka Y, Urade Y, Hayaishi O. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2376-82. PMID 9065498 DOI: 10.1523/Jneurosci.17-07-02376.1997  0.375
1997 HAYAISHI O. Mystery of sleep. Molecular mechanism of control of sleep. Nihon Naika Gakkai Zasshi. 86: 46-47. DOI: 10.2169/NAIKA.86.SUPPLEMENT_46  0.28
1997 Terao A, Matsumura H, Satoh S, Saito M, Hayaishi O. 905 Role of Cox-2 enzyme in the interleukin-1-induced slow-wave sleep Neuroscience Research. 28. DOI: 10.1016/S0168-0102(97)90295-9  0.412
1997 Yamashima T, Sakuda K, Yamashita J, Oda H, Beuckmann CT, Urade Y, Hayaishi O. 501 Prostaglandin D synthase (β-trace) in human meninges Neuroscience Research. 28. DOI: 10.1016/S0168-0102(97)90198-X  0.349
1996 Toh H, Kubodera H, Nakajima N, Sekiya T, Eguchi N, Tanaka T, Urade Y, Hayaishi O. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Engineering. 9: 1067-82. PMID 9010921 DOI: 10.1093/Protein/9.12.1067  0.351
1996 Takahata R, Matsumura H, Eguchi N, Kantha SS, Satoh S, Sakai T, Kondo N, Hayaishi O. Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 54: 77-81. PMID 8992498 DOI: 10.1016/S0952-3278(96)90085-X  0.34
1996 Melegos DN, Diamandis EP, Oda H, Urade Y, Hayaishi O. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clinical Chemistry. 42: 1984-91. PMID 8969637  0.26
1996 Okuda-Ashitaka E, Sakamoto K, Ezashi T, Miwa K, Ito S, Hayaishi O. Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype. The Journal of Biological Chemistry. 271: 31255-61. PMID 8940129 DOI: 10.1074/jbc.271.49.31255  0.365
1996 Urade Y, Hayaishi O, Matsumura H, Watanabe K. Molecular mechanism of sleep regulation by prostaglandin D2. Journal of Lipid Mediators and Cell Signalling. 14: 71-82. PMID 8906548 DOI: 10.1016/0929-7855(96)01511-8  0.416
1996 Hayaishi O. Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation. Advances in Experimental Medicine and Biology. 398: 285-9. PMID 8906279 DOI: 10.1007/978-1-4613-0381-7_45  0.375
1996 Hayaishi O. Tryptophan, oxygenase, and sleep. Advances in Experimental Medicine and Biology. 398: 3-11, vi. PMID 8906236 DOI: 10.1007/978-1-4613-0381-7_1  0.425
1996 Minami T, Okuda-Ashitaka E, Mori H, Ito S, Hayaishi O. Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. The Journal of Pharmacology and Experimental Therapeutics. 278: 1146-52. PMID 8819497  0.258
1996 Beuckmann CT, Gordon WC, Kanaoka Y, Eguchi N, Marcheselli VL, Gerashchenko DY, Urade Y, Hayaishi O, Bazan NG. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6119-24. PMID 8815894 DOI: 10.1523/Jneurosci.16-19-06119.1996  0.417
1996 Blödorn B, Mäder M, Urade Y, Hayaishi O, Felgenhauer K, Brück W. Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. Neuroscience Letters. 209: 117-20. PMID 8761996 DOI: 10.1016/0304-3940(96)12614-8  0.369
1996 Satoh S, Matsumura H, Suzuki F, Hayaishi O. Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. Proceedings of the National Academy of Sciences of the United States of America. 93: 5980-4. PMID 8650205 DOI: 10.1073/Pnas.93.12.5980  0.419
1996 ODA H, EGUCHI N, URADE Y, HAYAISHI O. Quantitative Sandwich Enzyme-linked Immunosorbent Assay for Human Secretory Prostaglandin D Synthase (.BETA.-Trace). Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences. 72: 108-111. DOI: 10.2183/PJAB.72.108  0.312
1996 Hayaishi O. Obituary for Fellow Member Professor Hideo Nishimura (1912–1995) Congenital Anomalies. 36: 54-55. DOI: 10.1111/j.1741-4520.1996.tb00620.x  0.183
1996 Melegos DN, Diamandis EP, Oda H, Urade Y, Hayaishi O. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids Clinical Chemistry. 42: 1984-1991. DOI: 10.1093/Clinchem/42.12.1984  0.262
1996 Hayaishi O. International Colloquium on β-trace: Opening remarks Prostaglandins. 51: 277-280. DOI: 10.1016/S0090-6980(96)90028-3  0.181
1996 Terao A, Matsumura H, Satoh S, Saito M, Hayaishi O. 1004 Sleep-promoting effect of interleukin- 1 β in the rostral basal forebrain Neuroscience Research. 25. DOI: 10.1016/0168-0102(96)88856-0  0.373
1996 Garcia-Fernandez LF, Rausell E, Fairen A, Urade Y, Hayaishi O, Bernal J, Munoz A. Rat brain prostaglandin D2 synthase is regulated by thyroid hormone in vivo Prostaglandins. 51: 302-306. DOI: 10.1016/0090-6980(96)86807-9  0.383
1996 Eguchi N, Kanaoka Y, Urade Y, Hayaishi O. Expression and cellular localization of β-trace in genital organs Prostaglandins. 51: 298. DOI: 10.1016/0090-6980(96)86803-1  0.304
1996 Yamashima T, Sakuda K, Tohma Y, Kida S, Yamashita J, Eguchi N, Kanaoka Y, Irikura D, Urade Y, Hayaishi O. Prostaglandin D synthase in human arachnoid, arachnoid villi and meningiomas Prostaglandins. 51: 287. DOI: 10.1016/0090-6980(96)86792-X  0.363
1996 Matsumura H, Satoh S, Pandey HP, Ram A, Gerashchenko D, Kasahara K, Nakajima T, Hayaishi O. Role of prostaglandin D2 in the regulation of sleep Prostaglandins. 51: 282. DOI: 10.1016/0090-6980(96)86787-6  0.406
1996 Hayaishi O. Introductory remarks - Prostaglandin D synthase, β-trace and sleep Prostaglandins. 51: 281. DOI: 10.1016/0090-6980(96)86786-4  0.399
1996 Hayaishi O. Prostaglandin d synthase, β-Trace and sleep Prostaglandins. 51: 281.  0.299
1995 Minami T, Onaka M, Okuda-Ashitaka E, Mori H, Ito S, Hayaishi O. L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2. Neuroscience Letters. 201: 239-42. PMID 8786849 DOI: 10.1016/0304-3940(95)12176-5  0.355
1995 Urade Y, Watanabe K, Hayaishi O. Prostaglandin D, E, and F synthases. Journal of Lipid Mediators and Cell Signalling. 12: 257-73. PMID 8777570 DOI: 10.1016/0929-7855(95)00032-L  0.356
1995 Pandey HP, Ram A, Matsumura H, Hayaishi O. Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. Biochemistry and Molecular Biology International. 37: 431-7. PMID 8595382  0.292
1995 Osaka T, Hayaishi O. Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. Neuroscience Research. 23: 257-68. PMID 8545074 DOI: 10.1016/0168-0102(95)00948-5  0.393
1995 Urade Y, Tanaka T, Eguchi N, Kikuchi M, Kimura H, Toh H, Hayaishi O. Structural and functional significance of cysteine residues of glutathione-independent prostaglandin D synthase. Identification of Cys65 as an essential thiol. The Journal of Biological Chemistry. 270: 1422-8. PMID 7836410 DOI: 10.1074/Jbc.270.3.1422  0.468
1995 Sakamoto K, Ezashi T, Miwa K, Okuda-Ashitaka E, Houtani T, Sugimoto T, Ito S, Hayaishi O. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 259-61. PMID 7732848  0.231
1995 Sakamoto K, Miwa K, Ezashi T, Okuda-Ashitaka E, Okuda K, Houtani T, Sugimoto T, Ito S, Hayaishi O. Expression of mRNA encoding the prostaglandin F2 alpha receptor in bovine corpora lutea throughout the oestrous cycle and pregnancy. Journal of Reproduction and Fertility. 103: 99-105. PMID 7707306 DOI: 10.1530/Jrf.0.1030099  0.335
1995 Minami T, Nishihara I, Ito S, Sakamoto K, Hyodo M, Hayaishi O. Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice. Pain. 61: 285-90. PMID 7659439 DOI: 10.1016/0304-3959(94)00183-F  0.368
1995 Minami T, Nishihara I, Sakamoto K, Ito S, Hyodo M, Hayaishi O. Blockade by ONO-NT-012, a unique prostanoid analogue, of prostaglandin E2-induced allodynia in conscious mice. British Journal of Pharmacology. 115: 73-6. PMID 7647986 DOI: 10.1111/J.1476-5381.1995.Tb16321.X  0.346
1995 Pandey HP, Ram A, Matsumura H, Satoh S, Hayaishi O. Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. Biochemical and Biophysical Research Communications. 213: 625-9. PMID 7646520 DOI: 10.1006/bbrc.1995.2177  0.387
1995 Matsumura H, Kinoshita G, Satoh S, Osaka T, Hayaishi O. A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal. Journal of Neuroscience Methods. 57: 145-9. PMID 7609577 DOI: 10.1016/0165-0270(94)00107-R  0.332
1995 Nishihara I, Minami T, Uda R, Ito S, Hyodo M, Hayaishi O. Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice. Brain Research. 677: 138-44. PMID 7606458 DOI: 10.1016/0006-8993(95)00133-B  0.361
1995 Vesin MF, Urade Y, Hayaishi O, Droz B. Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 470-6. PMID 7529829  0.273
1995 Nishihara I, Minami T, Watanabe Y, Ito S, Hayaishi O. Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord. Neuroscience Letters. 196: 57-60. PMID 7501257 DOI: 10.1016/0304-3940(95)11839-O  0.351
1995 Hayaishi O, Matsumura H. Prostaglandins and sleep. Advances in Neuroimmunology. 5: 211-6. PMID 7496614 DOI: 10.1016/0960-5428(95)00010-Y  0.399
1994 Ito S, Sakamoto K, Mochizuki-Oda N, Ezashi T, Miwa K, Okuda-Ashitaka E, Shevchenko VI, Kiso Y, Hayaishi O. Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. Biochemical and Biophysical Research Communications. 200: 756-62. PMID 8179609 DOI: 10.1006/bbrc.1994.1515  0.341
1994 Koyama Y, Hayaishi O. Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. Brain Research Bulletin. 33: 367-72. PMID 8124575 DOI: 10.1016/0361-9230(94)90278-X  0.391
1994 Hayaishi O. [Prostaglandins--present and future]. Nihon HinyåKika Gakkai Zasshi. the Japanese Journal of Urology. 85: 6-8. PMID 8107344  0.211
1994 Watanabe K, Urade Y, Mäder M, Murphy C, Hayaishi O. Identification of beta-trace as prostaglandin D synthase. Biochemical and Biophysical Research Communications. 203: 1110-6. PMID 8093029 DOI: 10.1006/bbrc.1994.2297  0.437
1994 Koyama Y, Hayaishi O. Firing of neurons in the preoptic/anterior hypothalamic areas in rat: its possible involvement in slow wave sleep and paradoxical sleep. Neuroscience Research. 19: 31-8. PMID 8008233 DOI: 10.1016/0168-0102(94)90005-1  0.394
1994 Matsumura H, Nakajima T, Osaka T, Satoh S, Kawase K, Kubo E, Kantha SS, Kasahara K, Hayaishi O. Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. Proceedings of the National Academy of Sciences of the United States of America. 91: 11998-2002. PMID 7991572 DOI: 10.1073/Pnas.91.25.11998  0.406
1994 Hayaishi O. Tryptophan, oxygen, and sleep. Annual Review of Biochemistry. 63: 1-24. PMID 7979234 DOI: 10.1146/annurev.bi.63.070194.000245  0.379
1994 Sri Kantha S, Matsumura H, Kubo E, Kawase K, Takahata R, Serhan CN, Hayaishi O. Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 51: 87-93. PMID 7972271 DOI: 10.1016/0952-3278(94)90083-3  0.41
1994 Minami T, Nishihara I, Uda R, Ito S, Hyodo M, Hayaishi O. Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice. British Journal of Pharmacology. 112: 735-40. PMID 7921597 DOI: 10.1111/J.1476-5381.1994.Tb13139.X  0.351
1994 Minami T, Nishihara I, Uda R, Ito S, Hyodo M, Hayaishi O. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice. Pain. 57: 225-31. PMID 7916453 DOI: 10.1016/0304-3959(94)90227-5  0.351
1994 Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. Pain. 57: 217-23. PMID 7916452 DOI: 10.1016/0304-3959(94)90226-7  0.249
1994 Satoh S, Matsumura H, Nakajima T, Onoe H, Sakai K, Nakajima T, Jouvet M, Hayaishi O. Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. Neuroscience Research. 21: 41-50. PMID 7708292 DOI: 10.1016/0168-0102(94)90066-3  0.42
1994 Sakamoto K, Ezashi T, Miwa K, Okuda-Ashitaka E, Houtani T, Sugimoto T, Ito S, Hayaishi O. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. The Journal of Biological Chemistry. 269: 3881-6. PMID 7508922  0.256
1994 Osaka T, Matsumura H, Hayaishi O. Prostaglandin D2 modulates activity of sleep-related neurons in the preoptic area and neighbouring basal forebrain of the rat Neuroscience Research Supplements. 19: S238. DOI: 10.1016/0921-8696(94)92941-6  0.412
1993 Hayaishi O. My life with tryptophan--never a dull moment. Protein Science : a Publication of the Protein Society. 2: 472-5. PMID 8453383 DOI: 10.1002/pro.5560020320  0.288
1993 Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N, Hayaishi O. Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proceedings of the National Academy of Sciences of the United States of America. 90: 9070-4. PMID 8415655 DOI: 10.1073/Pnas.90.19.9070  0.447
1993 Okuda-Ashitaka E, Sakamoto K, Giles H, Ito S, Hayaishi O. Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. Biochimica Et Biophysica Acta. 1176: 148-54. PMID 8384001 DOI: 10.1016/0167-4889(93)90190-Z  0.335
1993 Hayaishi O, Matsumura H, Urade Y. Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep. Journal of Lipid Mediators. 6: 429-31. PMID 8358001  0.359
1993 Takahata R, Matsumura H, Kantha SS, Kubo E, Kawase K, Sakai T, Hayaishi O. Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats. Brain Research. 623: 65-71. PMID 8221095 DOI: 10.1016/0006-8993(93)90010-K  0.421
1993 Osaka T, Matsumura H, Hayaishi O. 2025 Clonidine inhibits sleep-active neurons in the preoptic area in the rat Neuroscience Research Supplements. 18: S224. DOI: 10.1016/S0921-8696(05)81311-8  0.403
1993 Onoe H, Fukui-Ono K, Hayaishi O, Watanabe Y. 2003 Neurochemical regulatory mechanism of waking by prostaglandin E2 in the posterior hypothalamus of the rhesus monkey Neuroscience Research Supplements. 18: S217. DOI: 10.1016/S0921-8696(05)81289-7  0.344
1993 Matsumura H, Nakajima T, Kubo E, Kawase K, Kantha SS, Satoh S, Osaka T, Kinoshita G, Hayaishi O. 2002 Site of action for the sleep-promoting effect of prostaglandin D2 is located in the rostromedial basal forebrain in the rat Neuroscience Research Supplements. 18: S217. DOI: 10.1016/S0921-8696(05)81288-5  0.41
1993 Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N, Akazawa C, Suzuki T, Watanabe K, Hayaishi O. 2001 Expression of mRNA for prostaglandin D synthase in leptomeninges and choroid plexus of rat central nervous system, and secretion of the enzyme into the cerebrospinal fluid Neuroscience Research Supplements. 18: S216. DOI: 10.1016/S0921-8696(05)81287-3  0.41
1992 Onoe H, Watanabe Y, Ono K, Koyama Y, Hayaishi O. Prostaglandin E2 exerts an awaking effect in the posterior hypothalamus at a site distinct from that mediating its febrile action in the anterior hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 2715-25. PMID 1613554 DOI: 10.1523/Jneurosci.12-07-02715.1992  0.402
1992 Igarashi M, Nagata A, Toh H, Urade Y, Hayaishi O. Structural organization of the gene for prostaglandin D synthase in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. 89: 5376-80. PMID 1608945  0.293
1992 Chen LY, Watanabe K, Hayaishi O. Purification and characterization of prostaglandin F synthase from bovine liver. Archives of Biochemistry and Biophysics. 296: 17-26. PMID 1605628 DOI: 10.1016/0003-9861(92)90539-9  0.344
1992 Eguchi N, Kaneko T, Urade Y, Hayashi H, Hayaishi O. Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. The Journal of Pharmacology and Experimental Therapeutics. 262: 1110-20. PMID 1527717  0.261
1992 Fujimoto N, Kaneko T, Eguchi N, Urade Y, Mizuno N, Hayaishi O. Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain. Neuroscience. 49: 591-606. PMID 1501767 DOI: 10.1016/0306-4522(92)90229-U  0.364
1992 Hayaishi O. [Regulatory mechanism of sleep and arousal by PGD2 and PGE2]. Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica. 94: 815-9. PMID 1484902  0.286
1992 Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Allodynia evoked by intrathecal administration of prostaglandin F2 alpha to conscious mice. Pain. 50: 223-9. PMID 1408321 DOI: 10.1016/0304-3959(92)90166-9  0.341
1992 Kuchinke W, Barski O, Watanabe K, Hayaishi O. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Biochemical and Biophysical Research Communications. 183: 1238-46. PMID 1339268 DOI: 10.1016/S0006-291X(05)80323-7  0.407
1992 Ito S, Sugama K, Inagaki N, Fukui H, Giles H, Wada H, Hayaishi O. Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. Glia. 6: 67-74. PMID 1324890 DOI: 10.1002/glia.440060109  0.364
1992 Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Effects of Clonidine and Baclofen on Prostaglandin F2α- induced Allodynia in Conscious Mice Pain Research. 7: 129-134. DOI: 10.11154/PAIN.7.129  0.318
1992 Osaka T, Matsumura H, Hayaishi O. Responses of preoptic sleep-related neurons to stimulation of the locus ceruleus and the ventrolateral medulla in the rat Neuroscience Research Supplements. 17: 277. DOI: 10.1016/0921-8696(92)91220-Z  0.387
1992 Hayaishi O, Matsumura H, Onoe H, Urade Y. Molecular basis of sleep-wake regulation — Roles of prostaglandins D2 and E2 Neuroscience Research Supplements. 17: 27. DOI: 10.1016/0921-8696(92)90679-U  0.409
1991 Watanabe K, Fujii Y, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S, Hayaishi O. Expression of bovine lung prostaglandin F synthase in Escherichia coli. Biochemical and Biophysical Research Communications. 181: 272-8. PMID 1958196 DOI: 10.1016/S0006-291X(05)81413-5  0.294
1991 Nakajima M, Goh Y, Azuma I, Hayaishi O. Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fã¼R Klinische Und Experimentelle Ophthalmologie. 229: 411-3. PMID 1937072 DOI: 10.1007/BF00166301  0.241
1991 Matsumura H, Takahata R, Hayaishi O. Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase. Proceedings of the National Academy of Sciences of the United States of America. 88: 9046-50. PMID 1924366 DOI: 10.1073/Pnas.88.20.9046  0.43
1991 Islam F, Watanabe Y, Morii H, Hayaishi O. Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds. Archives of Biochemistry and Biophysics. 289: 161-6. PMID 1910313 DOI: 10.1016/0003-9861(91)90456-S  0.416
1991 Hayaishi O. Molecular mechanisms of sleep-wake regulation: roles of prostaglandins D2 and E2. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2575-81. PMID 1907936 DOI: 10.1096/Fasebj.5.11.1907936  0.406
1991 Tsubokura S, Watanabe Y, Ehara H, Imamura K, Sugimoto O, Kagamiyama H, Yamamoto S, Hayaishi O. Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain. Brain Research. 543: 15-24. PMID 1905180 DOI: 10.1016/0006-8993(91)91043-Z  0.368
1991 Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proceedings of the National Academy of Sciences of the United States of America. 88: 4020-4. PMID 1902577  0.348
1991 Ito S, Negishi M, Mochizuki-Oda N, Yokohama H, Hayaishi O. Sodium fluoride mimics the effect of prostaglandin E2 on catecholamine release from bovine adrenal chromaffin cells. Journal of Neurochemistry. 56: 44-51. PMID 1898968 DOI: 10.1111/J.1471-4159.1991.Tb02560.X  0.372
1991 Watanabe K, Fujii Y, Hayashi H, Urade Y, Hayaishi O. The structure and function of prostaglandin F synthase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 85-8. PMID 1825592  0.204
1991 Hayaishi O, Matsumura H, Onoe H, Koyama Y, Watanabe Y. Sleep-wake regulation by PGD2 and E2. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 723-6. PMID 1825402  0.288
1991 Onoe H, Watanabe Y, Tamura M, Hayaishi O. REM sleep-associated hemoglobin oxygenation in the monkey forebrain studied using near-infrared spectrophotometry. Neuroscience Letters. 129: 209-13. PMID 1745402 DOI: 10.1016/0304-3940(91)90463-4  0.384
1991 Ito S, Negishi M, Sugama K, Okuda-Ashitaka E, Hayaishi O. Signal transduction coupled to prostaglandin D2. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 371-4. PMID 1705384  0.223
1991 Takeuchi Y, Morii H, Tamura M, Hayaishi O, Watanabe Y. A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acid. Archives of Biochemistry and Biophysics. 289: 33-8. PMID 1654847 DOI: 10.1016/0003-9861(91)90438-O  0.311
1991 Koyama Y, Hayaishi O. Prostaglanins activate sleep-related neurons in the preoptic area of rats Neuroscience Research Supplements. 14: S154. DOI: 10.1016/S0921-8696(06)80450-0  0.394
1991 Onoe H, Tsukada H, Ito T, Suzuki K, Kitazume M, Kobayashi K, Mataga N, Hayaishi O, Watanabe Y, Inoue O, Tateno Y. Increase in striatal dopamine D1 and D2 receptor binding by ketamine: Positron emission tomography study using the conscious rhesus monkey Neuroscience Research Supplements. 14: S135. DOI: 10.1016/S0921-8696(06)80394-4  0.342
1991 Mori K, Ikeda J, Hayaishi O. The midsagittal radial glial system in postnatally developing and adult brainstem studied with monoclonal antibody R2D5 Neuroscience Research Supplements. 14: S36. DOI: 10.1016/S0921-8696(06)80097-6  0.303
1990 Urade Y, Ujihara M, Horiguchi Y, Igarashi M, Nagata A, Ikai K, Hayaishi O. Mast cells contain spleen-type prostaglandin D synthetase. The Journal of Biological Chemistry. 265: 371-5. PMID 2403560  0.356
1990 Hayashi H, Fujii Y, Watanabe K, Hayaishi O. Enzymatic formation of prostaglandin F2 alpha in human brain. Neurochemical Research. 15: 385-92. PMID 2388711 DOI: 10.1007/BF00969923  0.334
1990 Urade Y, Watanabe K, Eguchi N, Fujii Y, Hayaishi O. 9 alpha,11 beta-prostaglandin F2 formation in various bovine tissues. Different isozymes of prostaglandin D2 11-ketoreductase, contribution of prostaglandin F synthetase and its cellular localization. The Journal of Biological Chemistry. 265: 12029-35. PMID 2365709  0.306
1990 Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. Brain Research. 510: 26-32. PMID 2322844 DOI: 10.1016/0006-8993(90)90723-O  0.286
1990 Negishi M, Ito S, Hayaishi O. Involvement of protein kinase C in prostaglandin E2-induced catecholamine release from cultured bovine adrenal chromaffin cells. The Journal of Biological Chemistry. 265: 6182-8. PMID 2318853  0.259
1990 Nishino S, Mignot E, Kilduff TS, Sakai T, Hayaishi O, Dement WC. Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs. Biological Psychiatry. 28: 904-10. PMID 2268692 DOI: 10.1016/0006-3223(90)90570-R  0.394
1990 Mori K, Ikeda J, Hayaishi O. Monoclonal antibody R2D5 reveals midsagittal radial glial system in postnatally developing and adult brainstem. Proceedings of the National Academy of Sciences of the United States of America. 87: 5489-93. PMID 2196568 DOI: 10.1073/Pnas.87.14.5489  0.334
1990 Fujii Y, Watanabe K, Hayashi H, Urade Y, Kuramitsu S, Kagamiyama H, Hayaishi O. Purification and characterization of rho-crystallin from Japanese common bullfrog lens. The Journal of Biological Chemistry. 265: 9914-23. PMID 2190986  0.316
1990 Negishi M, Ito S, Hayaishi O. Arachidonic acid stimulates phosphoinositide metabolism and catecholamine release from bovine adrenal chromaffin cells. Biochemical and Biophysical Research Communications. 169: 773-9. PMID 2162673 DOI: 10.1016/0006-291X(90)90398-7  0.362
1990 Ito S, Okuda E, Sugama K, Negishi M, Hayaishi O. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British Journal of Pharmacology. 99: 13-4. PMID 2158830 DOI: 10.1111/J.1476-5381.1990.Tb14645.X  0.369
1990 Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Synergistic effect of prostaglandin E2 and ouabain on catecholamine release from cultured bovine adrenal chromaffin cells. Journal of Neurochemistry. 54: 86-95. PMID 2152800 DOI: 10.1111/J.1471-4159.1990.Tb13286.X  0.361
1990 Islam F, Watanabe Y, Hayaishi O. Inhibition of rat brain prostaglandin D synthase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Biochemistry International. 22: 601-5. PMID 2127671  0.319
1990 Islam F, Urade Y, Watanabe Y, Hayaishi O. A particle concentration fluorescence immunoassay for prostaglandin D synthase in the rat central nervous system. Archives of Biochemistry and Biophysics. 277: 290-5. PMID 2106829 DOI: 10.1016/0003-9861(90)90581-I  0.418
1990 Matsumura K, Watanabe Y, Onoe H, Watanabe Y, Hayaishi O. High density of prostaglandin E2 binding sites in the anterior wall of the 3rd ventricle: a possible site of its hyperthermic action. Brain Research. 533: 147-51. PMID 1964828 DOI: 10.1016/0006-8993(90)91808-T  0.338
1990 Koyama Y, Onoe H, Ono K, Watanabe Y, Hayaishi O. Sleep-suppressive effect of prostaglandin E2 can be dissociated from its pyrogenic effect in rhesus monkey Neuroscience Research Supplements. 11: S127. DOI: 10.1016/0921-8696(90)90832-N  0.385
1990 Islam F, Watanabe Y, Morii H, Hayaishi O. Effect of trace metals and nucleotide-related compounds on prostaglandin D synthetase activity in rat brain Neuroscience Research Supplements. 11. DOI: 10.1016/0921-8696(90)90692-V  0.38
1990 Matsumura H, Honda K, Sung Choi W, Inoué S, Sakai T, Hayaishi O. A role of prostaglandin E2 in physiological sleep-wakefulness regulation Neuroscience Research Supplements. 15: S126. DOI: 10.1016/0921-8696(90)90408-U  0.393
1990 Tsubokura S, Watanabe Y, Ehara H, Imamura K, Mori K, Sugimoto O, Kagamiyama H, Yamamoto S, Hayaishi O. Prostaglandin endoperoxide synthase exists in neurons and glial cells in monkey brain Neuroscience Research Supplements. 15: S80. DOI: 10.1016/0921-8696(90)90268-8  0.346
1990 Hayaishi O. Plenary Lecture Prostaglandins and the Brain—With Special Reference to Sleep-Wake Regulation by Prostaglandins D2 and E2 Wednesday, October 18 3:45-4:30 PM Stroke. 21: I-1-I-2.  0.307
1990 Hayaishi O. Prostaglandins and the brain - With special reference to sleep-wake regulation by prostaglandins D2 and E2 Stroke. 21: I-1-I-2.  0.322
1989 Nishino S, Mignot E, Fruhstorfer B, Dement WC, Hayaishi O. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Proceedings of the National Academy of Sciences of the United States of America. 86: 2483-7. PMID 2928344 DOI: 10.1073/Pnas.86.7.2483  0.383
1989 Watanabe Y, Watanabe Y, Hamada K, Bommelaer-Bayt MC, Dray F, Kaneko T, Yumoto N, Hayaishi O. Distinct localization of prostaglandin D2, E2 and F2 alpha binding sites in monkey brain. Brain Research. 478: 143-8. PMID 2924110 DOI: 10.1016/0006-8993(89)91486-8  0.369
1989 Hayashi H, Fujii Y, Watanabe K, Urade Y, Hayaishi O. Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lung. The Journal of Biological Chemistry. 264: 1036-40. PMID 2910843  0.333
1989 Hayaishi O. Prostaglandin D2 and sleep. Annals of the New York Academy of Sciences. 559: 374-81. PMID 2774407 DOI: 10.1111/J.1749-6632.1989.Tb22623.X  0.402
1989 Matsumura H, Honda K, Choi WS, Inoué S, Sakai T, Hayaishi O. Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. Proceedings of the National Academy of Sciences of the United States of America. 86: 5666-9. PMID 2748610 DOI: 10.1073/Pnas.86.14.5666  0.429
1989 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Hayashi H, Kagamiyama H, Nakanishi S, Hayaishi O. Prostaglandin F synthetase--a dual function enzyme. Progress in Clinical and Biological Research. 290: 351-64. PMID 2726822  0.275
1989 Matsumura H, Honda K, Goh Y, Ueno R, Sakai T, Inoué S, Hayaishi O. Awaking effect of prostaglandin E2 in freely moving rats. Brain Research. 481: 242-9. PMID 2720378 DOI: 10.1016/0006-8993(89)90800-7  0.313
1989 Hayashi H, Fujii Y, Watanabe K, Urade Y, Hayaishi O. Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver. Progress in Clinical and Biological Research. 290: 365-79. PMID 2657759  0.249
1989 Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O. Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence. The Journal of Biological Chemistry. 264: 1041-5. PMID 2642896  0.32
1989 Nishino S, Ueno R, Ohishi K, Sakai T, Hayaishi O. Salivary prostaglandin concentrations: possible state indicators for major depression. The American Journal of Psychiatry. 146: 365-8. PMID 2627202  0.184
1989 Ito S, Negishi M, Yokohama H, Tanaka T, Hayashi H, Katada T, Ui M, Hayaishi O. Enhancement of catecholamine release may be mediated by prostaglandin E receptor-stimulated phosphoinositide metabolism. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 19: 176-9. PMID 2546380  0.246
1989 Sugama K, Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. Biochimica Et Biophysica Acta. 1011: 75-80. PMID 2538150 DOI: 10.1016/0167-4889(89)90081-5  0.373
1989 Negishi M, Ito S, Hayaishi O. Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner. The Journal of Biological Chemistry. 264: 3916-23. PMID 2537296  0.288
1989 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Hayashi H, Kagamiyama H, Nakanishi S, Hayaishi O. Cloning, nucleotide sequence and gene expression of bovine lung prostaglandin F synthetase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 19: 462-5. PMID 2526518  0.211
1989 Hayaishi O. Prostaglandin D2 and sleep. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 19: 26-33. PMID 2526481  0.304
1989 Ito S, Narumiya S, Hayaishi O. Prostaglandin D2: a biochemical perspective. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 37: 219-34. PMID 2510183 DOI: 10.1016/0952-3278(89)90033-1  0.487
1989 Urade Y, Ujihara M, Horiguchi Y, Ikai K, Hayaishi O. The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. Journal of Immunology (Baltimore, Md. : 1950). 143: 2982-9. PMID 2509561  0.322
1989 Hatanaka M, Yumoto N, Miwa N, Morii H, Tanemura M, Ueno R, Watanabe Y, Hayaishi O. Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. Journal of Neurochemistry. 53: 1450-5. PMID 2507741 DOI: 10.1111/j.1471-4159.1989.tb08537.x  0.245
1989 Carper DA, Wistow G, Nishimura C, Graham C, Watanabe K, Fujii Y, Hayashi H, Hayaishi O. A superfamily of NADPH-dependent reductases in eukaryotes and prokaryotes. Experimental Eye Research. 49: 377-88. PMID 2507340  0.282
1989 Goh Y, Araie M, Nakajima M, Azuma I, Hayaishi O. Effect of topical prostaglandin D2 on the aqueous humor dynamics in rabbits. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fã¼R Klinische Und Experimentelle Ophthalmologie. 227: 476-81. PMID 2478423 DOI: 10.1007/BF02172902  0.222
1989 Watanabe Y, Langstrom B, Hamada K, Gillberg PG, Stalnacke CG, Hatanaka M, Hayashi H, Hayaishi O. Functional-site study of prostaglandins in the monkey brain using quantitative autoradiography and positron emission tomography Annals of the New York Academy of Sciences. 559: 494-496. DOI: 10.1111/J.1749-6632.1989.Tb22653.X  0.323
1989 Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O. Primary structure of rat brain prostaglandin D synthetase deduced from the cDNA sequence Annals of the New York Academy of Sciences. 559: 491-493. DOI: 10.1111/J.1749-6632.1989.Tb22652.X  0.377
1989 Ito S, Negishi M, Hayashi H, Hayaishi O. The role and new action mechanism of prostaglandin E2 in neurotransmission Annals of the New York Academy of Sciences. 559: 453-454. DOI: 10.1111/J.1749-6632.1989.Tb22638.X  0.337
1989 Hayashi H, Eguchi N, Urade Y, Ito S, Hayaishi O. Prostaglandin E2 administered intravenously crosses the blood-brain barrier and induces hyperthermia as a central action Annals of the New York Academy of Sciences. 559: 451-452. DOI: 10.1111/J.1749-6632.1989.Tb22637.X  0.347
1989 Hayaishi O. Foreword III Biomedical Research. 10: x. DOI: 10.1016/S0070-2153(08)60647-X  0.185
1989 Watanabe Y, Långström B, Hayaishi O. Chemical anatomy of living animal and molecular analysis of higher brain functions by positron emission tomography Neuroscience Research Supplements. 9: 14. DOI: 10.1016/0921-8696(89)90520-3  0.323
1989 Hayaishi O, Takikawa O, Yoshida R. Indoleamine 2, 3-dioxygenase: Properties and functions of a superoxide utilizing enzyme Journal of Inorganic Biochemistry. 36: 152. DOI: 10.1016/0162-0134(89)84026-7  0.39
1988 Sugino H, Miwa T, Ueno R, Hayaishi O. Alteration in morphology and induction of glutamine synthetase in rat glioma C6BU-1 cells cultured with prostaglandin D(2)-supplemented media. Neurochemistry International. 12: 5-12. PMID 20501196  0.289
1988 Ohishi K, Ueno R, Nishino S, Sakai T, Hayaishi O. Increased level of salivary prostaglandins in patients with major depression. Biological Psychiatry. 23: 326-34. PMID 3422573 DOI: 10.1016/0006-3223(88)90283-1  0.315
1988 Hayaishi O, Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S. Prostaglandin F synthetase, a dual function enzyme. Progress in Clinical and Biological Research. 274: 577-87. PMID 3406039  0.275
1988 Naito K, Osama H, Ueno R, Hayaishi O, Honda K, Inoué S. Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats. Brain Research. 453: 329-36. PMID 3401770 DOI: 10.1016/0006-8993(88)90173-4  0.404
1988 Ito S, Tanaka T, Hayashi H, Hayaishi O. Problems in production of prostaglandin D2-specific antibody. Eicosanoids. 1: 111-6. PMID 3273218  0.265
1988 Goh Y, Nakajima M, Azuma I, Hayaishi O. Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. Japanese Journal of Ophthalmology. 32: 471-80. PMID 3236567  0.255
1988 Eguchi N, Hayashi H, Urade Y, Ito S, Hayaishi O. Central action of prostaglandin E2 and its methyl ester in the induction of hyperthermia after their systemic administration in urethane-anesthetized rats. The Journal of Pharmacology and Experimental Therapeutics. 247: 671-9. PMID 3183962  0.264
1988 Goh Y, Nakajima M, Azuma I, Hayaishi O. Prostaglandin D2 reduces intraocular pressure. The British Journal of Ophthalmology. 72: 461-4. PMID 3164634  0.233
1988 Watanabe Y, Watanabe Y, Hayaishi O. Quantitative autoradiographic localization of prostaglandin E2 binding sites in monkey diencephalon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2003-10. PMID 3164357  0.238
1988 Onoe H, Ueno R, Fujita I, Nishino H, Oomura Y, Hayaishi O. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proceedings of the National Academy of Sciences of the United States of America. 85: 4082-6. PMID 3163802 DOI: 10.1073/Pnas.85.11.4082  0.409
1988 Matsumura H, Goh Y, Ueno R, Sakai T, Hayaishi O. Awaking effect of PGE2 microinjected into the preoptic area of rats. Brain Research. 444: 265-72. PMID 3162820  0.293
1988 Ujihara M, Urade Y, Eguchi N, Hayashi H, Ikai K, Hayaishi O. Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. Archives of Biochemistry and Biophysics. 260: 521-31. PMID 3124755 DOI: 10.1016/0003-9861(88)90477-8  0.414
1988 Yamamoto K, Miwa T, Ueno R, Hayaishi O. Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. Biochemical and Biophysical Research Communications. 156: 882-8. PMID 3056405  0.27
1988 Hirata Y, Hayashi H, Ito S, Kikawa Y, Ishibashi M, Sudo M, Miyazaki H, Fukushima M, Narumiya S, Hayaishi O. Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. The Journal of Biological Chemistry. 263: 16619-25. PMID 3053696  0.453
1988 Hayaishi O. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of Biological Chemistry. 263: 14593-6. PMID 3049580  0.309
1988 Negishi M, Ito S, Yokohama H, Hayashi H, Katada T, Ui M, Hayaishi O. Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. The Journal of Biological Chemistry. 263: 6893-900. PMID 2896200  0.257
1988 Yokohama H, Tanaka T, Ito S, Negishi M, Hayashi H, Hayaishi O. Prostaglandin E receptor enhancement of catecholamine release may be mediated by phosphoinositide metabolism in bovine adrenal chromaffin cells. The Journal of Biological Chemistry. 263: 1119-22. PMID 2891706  0.269
1988 Yokohama H, Negishi M, Sugama K, Hayashi H, Ito S, Hayaishi O. Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells. The Biochemical Journal. 255: 957-62. PMID 2850804 DOI: 10.1042/Bj2550957  0.391
1988 Miwa N, Sugino H, Ueno R, Hayaishi O. Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. Journal of Neurochemistry. 50: 1418-24. PMID 2834513  0.233
1988 Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S, Hayaishi O. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proceedings of the National Academy of Sciences of the United States of America. 85: 11-5. PMID 2829166 DOI: 10.1073/Pnas.85.1.11  0.55
1988 Suzuki S, Watanabe Y, Tsubokura S, Kagamiyama H, Hayaishi O. Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase. Brain Research. 446: 1-10. PMID 2453255  0.304
1988 Onoe H, Ueno R, Hayaishi O, Fujita I, Nishino H, Oomura Y. Molecular specificity of prostaglandins of their sleep-inducing effects Neuroscience Research Supplements. 7: S190. DOI: 10.1016/0921-8696(88)90388-X  0.39
1988 Yokohama H, Negishi M, Sugama K, Hayashi H, Ito S, Hayaishi O. Phorbol ester inhibits PGE2-induced phosphoinositide metabolism in bovine adrenal chromaffin cells Neuroscience Research Supplements. 7: S174. DOI: 10.1016/0921-8696(88)90359-3  0.369
1988 Mori K, Watanabe Y, Yumoto N, Fujita SC, Obata K, Hayaishi O. Telencephalon-specific antigen: Biochemical characterization and postnatal development Neuroscience Research Supplements. 7: S123. DOI: 10.1016/0921-8696(88)90256-3  0.313
1988 Miwa N, Ueno R, Hayaishi O. The effect of prostaglandin on cellular calcium concentration in neuronal cells in culture Neuroscience Research Supplements. 7. DOI: 10.1016/0921-8696(88)90253-8  0.318
1988 Ueno R, Miwa N, Yamamoto K, Hayaishi O. Molecular aspect of PGD2 on inducing sleep Neuroscience Research Supplements. 7: S7. DOI: 10.1016/0921-8696(88)90030-8  0.384
1987 Tanaka T, Yokohama H, Negishi M, Hayashi H, Ito S, Hayaishi O. Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells. Biochemical and Biophysical Research Communications. 144: 907-14. PMID 3579947 DOI: 10.1016/S0006-291X(87)80050-5  0.351
1987 Goh Y, Urade Y, Fujimoto N, Hayaishi O. Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. Biochimica Et Biophysica Acta. 921: 302-11. PMID 3477292  0.317
1987 Hayashi H, Ito S, Tanaka T, Negishi M, Kawabe H, Yokohama H, Watanabe K, Hayaishi O. Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. Prostaglandins. 33: 517-30. PMID 3474704 DOI: 10.1016/0090-6980(87)90275-9  0.367
1987 Hayashi H, Ito S, Watanabe K, Negishi M, Shintani T, Hayaishi O. Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. Biochimica Et Biophysica Acta. 917: 356-64. PMID 3467796  0.286
1987 Suzuki F, Hayashi H, Ito S, Hayaishi O. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochimica Et Biophysica Acta. 917: 224-30. PMID 3467795  0.28
1987 Yoshida R, Hayaishi O. Indoleamine 2,3-dioxygenase. Methods in Enzymology. 142: 188-95. PMID 3298973 DOI: 10.1016/S0076-6879(87)42028-4  0.363
1987 Mori K, Fujita SC, Watanabe Y, Obata K, Hayaishi O. Telencephalon-specific antigen identified by monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. 84: 3921-5. PMID 3295872 DOI: 10.1073/Pnas.84.11.3921  0.327
1987 Tachibana M, Fex J, Urade Y, Hayaishi O. Brain-type prostaglandin D synthetase occurs in the rat cochlea. Proceedings of the National Academy of Sciences of the United States of America. 84: 7677-80. PMID 3118375 DOI: 10.1073/Pnas.84.21.7677  0.436
1987 Urade Y, Fujimoto N, Kaneko T, Konishi A, Mizuno N, Hayaishi O. Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain. The Journal of Biological Chemistry. 262: 15132-6. PMID 3117794  0.3
1987 Hayaishi O. Prostaglandins: fundamental and clinical aspects. Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association. 86: 341-7. PMID 3110367  0.183
1987 Urade Y, Fujimoto N, Ujihara M, Hayaishi O. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. The Journal of Biological Chemistry. 262: 3820-5. PMID 3102495  0.373
1987 Takai K, Hayaishi O. Purification and properties of tryptophan side chain oxidase types I and II from Pseudomonas. Methods in Enzymology. 142: 195-217. PMID 3037258 DOI: 10.1016/S0076-6879(87)42029-6  0.333
1987 Hayaishi O, Ueno R, Onoe H, Osama H, Fujita I, Nishino H, Oomura Y. Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 946-8. PMID 2960208  0.307
1987 Watanabe Y, LÃ¥ngström B, StÃ¥lnacke CG, Gullberg P, Svärd H, Halldin C, Hayaishi O. Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 943-5. PMID 2960207  0.201
1987 Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 44-6. PMID 2959094  0.246
1987 Ueno R, Kuno S, Hayaishi O. Possible pathogenesis of acquired immune deficiency syndrome in homosexual males: an unexpected action of seminal prostaglandin E2 on AIDS-virus infection. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 151-4. PMID 2959040  0.196
1987 Yumoto N, Hatanaka M, Watanabe Y, Hayaishi O. Solubilization, separation, and reconstitution of brain prostaglandin E2 receptor and GTP-regulatory component. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 471-3. PMID 2889339  0.252
1987 Negishi M, Ito S, Tanaka T, Yokohama H, Hayashi H, Katada T, Ui M, Hayaishi O. Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein. The Journal of Biological Chemistry. 262: 12077-84. PMID 2887564  0.265
1987 Gullberg P, Watanabe Y, Svärd H, Hayaishi O, LÃ¥ngström B. Syntheses of [11C]methyl esters of prostaglandins D2 and E2. International Journal of Radiation Applications and Instrumentation. Part a, Applied Radiation and Isotopes. 38: 647-9. PMID 2822623 DOI: 10.1016/0883-2889(87)90132-8  0.349
1987 Kawabe H, Hayashi H, Hayaishi O. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. Biochemical and Biophysical Research Communications. 143: 467-74. PMID 2436614 DOI: 10.1016/0006-291X(87)91377-5  0.335
1987 NARUSE H, HAYASHI T, TAKESADA M, NAKANE A, YAMAZAKI K, NOGUCHI T, WATANABE Y, HAYAISHI O. Therapeutic effect of tetrahydrobiopterin in infantile autism. Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences. 63: 231-233. DOI: 10.2183/PJAB.63.231  0.176
1987 Kawata R, Tachibana M, Urade Y, Hayaishi O. Prostaglandin Synthesis by the Cochlea Ear Research Japan. 18: 69-72. DOI: 10.11289/Otoljpn1981.18.69  0.344
1987 Tachibana M, Urade Y, Hayaishi O, Fex J. Prostaglandin D Synthetase in the Inner Ear I. Immunocytochemical localization in the rat cochlea Ear Research Japan. 18: 66-68. DOI: 10.11289/Otoljpn1981.18.66  0.369
1987 Takai K, Hayaishi O. [27] Purification and properties of tryptophan side chain oxidase types I and II from pseudomonas Methods in Enzymology. 142: 195-217. DOI: 10.1016/S0076-6879(87)42029-6  0.224
1987 Ueno R, Onoe H, Hayaishi O, Fujita I, Nishino H, Oomura Y. Sleep inducing effects of PGD2 Neuroscience Research Supplements. 5: S173. DOI: 10.1016/0921-8696(87)90357-4  0.385
1987 Tanaka T, Yokohama H, Ito S, Negishi M, Hayashi H, Hayaishi O. Synergetic action of prostaglandin E2 and ouabain on catecholamine release from cultured bovine adrenal chromaffin cells Neuroscience Research Supplements. 5: S121. DOI: 10.1016/0921-8696(87)90255-6  0.337
1987 Watanabe Y, Langstrom B, Yumoto N, Hatanaka M, Watanabe Y, Hayashi H, Hayaishi O. Uptake of 11C-labeled prostaglandin D2 into monkey brain by positron emission tomography study Neuroscience Research Supplements. 5: S108. DOI: 10.1016/0921-8696(87)90230-1  0.347
1987 Mori K, Fujita SC, Watanabe Y, Obata K, Hayaishi O. Telencephalon specific antigen — An immunohistochemical analysis using a monoclonal antibody Neuroscience Research Supplements. 5: S40. DOI: 10.1016/0921-8696(87)90097-1  0.299
1986 Park SW, Ueno R, Hayaishi O. Prostaglandin synthesizing enzyme activities of hepatocytes and non-hepatocytes in rat liver as a function of age. Biochemistry International. 13: 827-34. PMID 3814160  0.316
1986 Hatakeyama K, Nemoto Y, Ueda K, Hayaishi O. Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose). The Journal of Biological Chemistry. 261: 14902-11. PMID 3771556  0.269
1986 Hiroshima O, Hayashi H, Ito S, Hayaishi O. Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. Prostaglandins. 32: 63-80. PMID 3532208 DOI: 10.1016/0090-6980(86)90144-9  0.424
1986 Yoshida R, Oku T, Imanishi J, Kishida T, Hayaishi O. Interferon: a mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly(I) X poly(C), and pokeweed mitogen in mouse lung. Archives of Biochemistry and Biophysics. 249: 596-604. PMID 3489442  0.245
1986 Suzuki F, Hayashi H, Hayaishi O. Transport of prostaglandin D2 into brain. Brain Research. 385: 321-8. PMID 3465420 DOI: 10.1016/0006-8993(86)91079-6  0.388
1986 Horiguchi S, Ueno R, Hyodo M, Hayaishi O. Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. European Journal of Pharmacology. 122: 173-9. PMID 3458588 DOI: 10.1016/0014-2999(86)90100-7  0.364
1986 Kuno S, Ueno R, Hayaishi O. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. Proceedings of the National Academy of Sciences of the United States of America. 83: 2682-3. PMID 3458226 DOI: 10.1073/Pnas.83.8.2682  0.34
1986 Watanabe K, Iguchi Y, Iguchi S, Arai Y, Hayaishi O, Roberts LJ. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. Proceedings of the National Academy of Sciences of the United States of America. 83: 1583-7. PMID 3456602  0.301
1986 Yumoto N, Watanabe Y, Watanabe K, Watanabe Y, Hayaishi O. Solubilization and characterization of prostaglandin E2 binding protein from porcine cerebral cortex. Journal of Neurochemistry. 46: 125-32. PMID 3455668  0.263
1986 Kuno S, Ueno R, Hayaishi O, Nakashima H, Harada S, Yamamoto N. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83: 3487-90. PMID 3010301  0.216
1986 Watanabe Y, Mori K, Imamura K, Takagi SF, Hayaishi O. Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. Brain Research. 378: 216-22. PMID 2873871 DOI: 10.1016/0006-8993(86)90924-8  0.342
1986 Yumoto N, Hatanaka M, Watanabe Y, Hayaishi O. Involvement of GTP-regulatory protein in brain prostaglandin E2 receptor and separation of the two components. Biochemical and Biophysical Research Communications. 135: 282-9. PMID 2869755 DOI: 10.1016/0006-291X(86)90974-5  0.357
1986 Tokumoto H, Watanabe Y, Yamashita A, Arai Y, Hayaishi O. Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain. Brain Research. 362: 114-21. PMID 2867812  0.295
1986 Yasui H, Takai K, Yoshida R, Hayaishi O. Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 83: 6622-6. PMID 2428037 DOI: 10.1073/Pnas.83.17.6622  0.363
1986 Takikawa O, Yoshida R, Kido R, Hayaishi O. Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. The Journal of Biological Chemistry. 261: 3648-53. PMID 2419335  0.319
1986 Kuno S, Ueno R, Hayaishi O. Regulation of Ca2+/calmodulin-dependent protein phosphorylation by prostaglandin D2 in mitochondrial fractions of rat brain Neuroscience Research Supplements. 3. DOI: 10.1016/0921-8696(86)90219-7  0.372
1986 Ueno R, Hayashi Y, Miwa N, Hayaishi O. The effects of prostaglandins on the differentiation of NG108-15 hybrid cells Neuroscience Research Supplements. 3. DOI: 10.1016/0921-8696(86)90218-5  0.318
1986 Kaneko T, Urade Y, Fujimoto N, Konishi A, Mizuno N, Hayaishi O. Distribution of prostaglandin D synthetase-containing neurons in the brain of adult rats Neuroscience Research Supplements. 3: S97. DOI: 10.1016/0921-8696(86)90207-0  0.374
1986 Urade Y, Kaneko T, Fujimoto N, Konishi A, Mizuno N, Hayaishi O. Immunohistochemical studies of prostaglandin D synthetase in the brain of fetal and newborn rats Neuroscience Research Supplements. 3: S97. DOI: 10.1016/0921-8696(86)90206-9  0.39
1985 Hayaishi O. Medical research and its impact on future society. World Hospitals. 21: 14-6. PMID 10274907  0.169
1985 Hayaishi O, Ueda K, Oka J, Komura H, Nakanishi K. 3-Deoxy-D-glycero-pentos-2-ulose, a novel pentose derived from poly(ADP-ribosyl) histones. Current Topics in Cellular Regulation. 27: 253-64. PMID 4092491 DOI: 10.1016/B978-0-12-152827-0.50029-3  0.289
1985 Miwa S, Watanabe Y, Hayaishi O. 6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain. Archives of Biochemistry and Biophysics. 239: 234-41. PMID 4004257 DOI: 10.1016/0003-9861(85)90831-8  0.248
1985 Urade Y, Fujimoto N, Hayaishi O. Purification and characterization of rat brain prostaglandin D synthetase. The Journal of Biological Chemistry. 260: 12410-5. PMID 3930495  0.35
1985 Tanaka T, Ito S, Hiroshima O, Hayashi H, Hayaishi O. Rat monoclonal antibody specific for prostaglandin E structure. Biochimica Et Biophysica Acta. 836: 125-33. PMID 3927979  0.238
1985 Ueda K, Hayaishi O. ADP-ribosylation. Annual Review of Biochemistry. 54: 73-100. PMID 3927821 DOI: 10.1146/annurev.bi.54.070185.000445  0.247
1985 Ueno R, Osama H, Urade Y, Hayaishi O. Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. Journal of Neurochemistry. 45: 483-9. PMID 3925085  0.317
1985 Park SW, Ueno R, Hayaishi O. Developmental changes in the activities of prostaglandin synthesizing enzymes in the digestive and immune systems of rat. Biochemistry International. 10: 873-9. PMID 3862409  0.31
1985 Watanabe K, Yoshida R, Shimizu T, Hayaishi O. Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. The Journal of Biological Chemistry. 260: 7035-41. PMID 3858278  0.34
1985 Watanabe Y, Watanabe Y, Kaneko T, Hayaishi O. Localization of prostaglandin bindings in the central nervous system. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 553-4. PMID 3004147  0.203
1985 Watanabe Y, Tokumoto H, Yamashita A, Narumiya S, Mizuno N, Hayaishi O. Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. Brain Research. 342: 110-6. PMID 2994820 DOI: 10.1016/0006-8993(85)91358-7  0.448
1985 Ueno R, Hayaishi O, Inoué S, Nakayama T. Prostaglandin D2: a cerebral sleep-regulating substance in rats. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 581-3. PMID 2936173  0.318
1985 Urade Y, Kaneko T, Fujimoto N, Watanabe Y, Mizuno N, Hayaishi O. Purification, characterization, and immunohistochemistry of rat brain prostaglandin D synthetase. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 549-51. PMID 2936167  0.296
1985 Watanabe K, Yoshida R, Shimizu T, Hayaishi O. Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 15: 151-3. PMID 2936081  0.301
1985 Hayaishi O. Indoleamine 2,3-dioxygenase--with special reference to the mechanism of interferon action. Biken Journal. 28: 39-49. PMID 2416307  0.205
1985 Kaneko T, Urade Y, Fujimoto N, Watanabe Y, Konishi A, Mizuno N, Hayaishi O. Distribution of prostaglandin D synthetase in cerebral neocortical neurons: An immunohistochemical study in neonatal rats Neuroscience Research Supplements. 1. DOI: 10.1016/S0921-8696(85)80062-1  0.364
1985 Urade Y, Kaneko T, Fujimoto N, Watanabe Y, Konishi A, Mizuno N, Hayaishi O. Prostaglandin D synthetase exists in both neurons and oligodendrocytes: An immunohistochemical study in adult rats Neuroscience Research Supplements. 1: S32. DOI: 10.1016/S0921-8696(85)80060-8  0.362
1985 Urade Y, Kaneko T, Fujimoto N, Watanabe Y, Konishi A, Mizuno N, Hayaishi O. Prostaglandin D synthetase exists in both neurons and oligodendrocytes: An immunohistochemical study in adult rats Neuroscience Research. 3: S32. DOI: 10.1016/0168-0102(85)90113-0  0.256
1984 Oka J, Ueda K, Hayaishi O, Komura H, Nakanishi K. ADP-ribosyl protein lyase. Purification, properties, and identification of the product. The Journal of Biological Chemistry. 259: 986-95. PMID 6693407  0.335
1984 Inoué S, Honda K, Komoda Y, Uchizono K, Ueno R, Hayaishi O. Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. Neuroscience Letters. 49: 207-11. PMID 6593603 DOI: 10.1016/0304-3940(84)90161-7  0.398
1984 Inoué S, Honda K, Komoda Y, Uchizono K, Ueno R, Hayaishi O. Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. Proceedings of the National Academy of Sciences of the United States of America. 81: 6240-4. PMID 6592612 DOI: 10.1073/Pnas.81.19.6240  0.396
1984 Kikawa Y, Narumiya S, Fukushima M, Wakatsuka H, Hayaishi O. 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. Proceedings of the National Academy of Sciences of the United States of America. 81: 1317-21. PMID 6584883 DOI: 10.1073/Pnas.81.5.1317  0.512
1984 Hayaishi O. The brain and prostaglandins. Bulletin of the Osaka Medical School. Supplement. 14: 1-17. PMID 6443188  0.234
1984 Eguchi N, Watanabe Y, Kawanishi K, Hashimoto Y, Hayaishi O. Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives. Archives of Biochemistry and Biophysics. 232: 602-9. PMID 6431906  0.322
1984 Ogorochi T, Narumiya S, Mizuno N, Yamashita K, Miyazaki H, Hayaishi O. Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. Journal of Neurochemistry. 43: 71-82. PMID 6427411 DOI: 10.1111/J.1471-4159.1984.Tb06680.X  0.484
1984 Ueda K, Hayaishi O. Evidence for poly(ADP-ribosyl) derivatives of carboxylates in histone. Methods in Enzymology. 106: 450-61. PMID 6387381 DOI: 10.1016/0076-6879(84)06049-3  0.356
1984 Yoshida R, Hayaishi O. Overview: superoxygenase. Methods in Enzymology. 105: 61-70. PMID 6203011 DOI: 10.1016/S0076-6879(84)05009-6  0.395
1984 Ohashi Y, Ueda K, Hayaishi O, Ikai K, Niwa O. Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 7132-6. PMID 6095269 DOI: 10.1073/Pnas.81.22.7132  0.398
1984 Ueda K, Zhang J, Hayaishi O. Poly(ADP-ribose) synthetase. Methods in Enzymology. 106: 500-4. PMID 6092836 DOI: 10.1016/0076-6879(84)06054-7  0.433
1983 Zavala F, Takai K, Hayaishi O. Isolation and characterization of the common intermediate in dichotomous reaction catalyzed by tryptophan side chain oxidase. The Journal of Biological Chemistry. 258: 344-51. PMID 6848506  0.232
1983 Ueda K, Ohashi Y, Hatakeyama K, Hayaishi O. Inhibition of DNA ligase activity by histones and its reversal by poly(ADP-ribose). Princess Takamatsu Symposia. 13: 175-82. PMID 6654829  0.232
1983 Hayaishi O. [The brain and prostaglandins]. Rinshå Shinkeigaku = Clinical Neurology. 23: 1056-66. PMID 6587956  0.234
1983 Ueno R, Honda K, Inoué S, Hayaishi O. Prostaglandin D2, a cerebral sleep-inducing substance in rats. Proceedings of the National Academy of Sciences of the United States of America. 80: 1735-7. PMID 6572936  0.313
1983 Osama H, Narumiya S, Hayaishi O, Iinuma H, Takeuchi T, Umezawa H. Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. Biochimica Et Biophysica Acta. 752: 251-8. PMID 6407532  0.496
1983 Ohashi Y, Ueda K, Kawaichi M, Hayaishi O. Activation of DNA ligase by poly(ADP-ribose) in chromatin. Proceedings of the National Academy of Sciences of the United States of America. 80: 3604-7. PMID 6407017 DOI: 10.1073/Pnas.80.12.3604  0.356
1983 Takikawa O, Yoshida R, Hayaishi O. Monooxygenase activities of dioxygenases. Benzphetamine demethylation and aniline hydroxylation reactions catalyzed by indoleamine 2,3-dioxygenase. The Journal of Biological Chemistry. 258: 6808-15. PMID 6406489  0.252
1983 Hirai K, Ueda K, Hayaishi O. Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. Cancer Research. 43: 3441-6. PMID 6406058  0.252
1983 Urade Y, Yoshida R, Kitamura H, Hayaishi O. Induction of indoleamine 2,3-dioxygenase in alveolar interstitial cells of mouse lung by bacterial lipopolysaccharide. The Journal of Biological Chemistry. 258: 6621-7. PMID 6343379  0.282
1983 Kawaichi M, Oka J, Zhang J, Ueda K, Hayaishi O. Properties of poly(ADP-ribose) synthetase and ADP-ribosyl histone splitting enzyme. Princess Takamatsu Symposia. 13: 121-8. PMID 6317633  0.338
1983 Yamashita A, Watanabe Y, Hayaishi O. Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 80: 6114-8. PMID 6310617 DOI: 10.1073/Pnas.80.19.6114  0.365
1983 Watanabe Y, Yamashita A, Tokumoto H, Hayaishi O. Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 80: 4542-5. PMID 6308629  0.295
1983 Hayaishi O. Prostaglandin D2: a neuromodulator. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 12: 333-7. PMID 6221610  0.253
1983 KOMURA H, IWASHITA T, NAOKI H, NAKANISHI K, OKA J, UEDA K, HAYAISHI O. ChemInform Abstract: STRUCTURE AND SYNTHESIS OF 3-DEOXY-D-GLYCERO-PENTOS-2-ULOSE, AN UNUSUAL SUGAR PRODUCED ENZYMATICALLY FROM (ADP-RIBOSYL)HISTONE H2B Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198345327  0.273
1982 Hayaishi O. [Prostaglandins--current progress in research]. Nihon Naibunpi Gakkai Zasshi. 58: 1403-12. PMID 7160495  0.178
1982 Shimizu T, Yamamoto S, Hayaishi O. Purification of PGH-PGD isomerase from rat brain. Methods in Enzymology. 86: 73-7. PMID 7132774 DOI: 10.1016/0076-6879(82)86171-5  0.402
1982 Shimizu T, Watanabe K, Tokumoto H, Hayaishi O. Isolation of NADP+-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain. Methods in Enzymology. 86: 147-52. PMID 7132752 DOI: 10.1016/0076-6879(82)86184-3  0.393
1982 Watanabe T, Shimizu T, Narumiya S, Hayaishi O. [Metabolism and action of prostaglandin D2 in blood platelets]. Rinsho Byori. the Japanese Journal of Clinical Pathology. 9-20. PMID 7131811  0.43
1982 Urade Y, Yoshida R, Kitamura H, Hayaishi O. Heterogeneous localization of two cytochrome P-450-dependent monooxygenase activities in dispersed cells of mouse lung. Biochemical and Biophysical Research Communications. 105: 567-74. PMID 6980003  0.22
1982 Ueno R, Narumiya S, Ogorochi T, Nakayama T, Ishikawa Y, Hayaishi O. Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 79: 6093-7. PMID 6964402 DOI: 10.1073/Pnas.79.19.6093  0.528
1982 Fukushima M, Kato T, Ota K, Arai Y, Narumiya S, Hayaishi O. 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. Biochemical and Biophysical Research Communications. 109: 626-33. PMID 6961920 DOI: 10.1016/0006-291X(82)91986-6  0.442
1982 Ueno R, Ishikawa Y, Nakayama T, Hayaishi O. Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. Biochemical and Biophysical Research Communications. 109: 576-82. PMID 6960896  0.318
1982 Narumiya S, Ogorochi T, Nakao K, Hayaishi O. Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. Life Sciences. 31: 2093-103. PMID 6960222 DOI: 10.1016/0024-3205(82)90101-1  0.524
1982 Tokumoto H, Watanabe K, Fukushima D, Shimizu T, Hayaishi O. An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. The Journal of Biological Chemistry. 257: 13576-80. PMID 6958674  0.371
1982 Watanabe T, Shimizu T, Narumiya S, Hayaishi O. NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. Archives of Biochemistry and Biophysics. 216: 372-9. PMID 6954879 DOI: 10.1016/0003-9861(82)90223-5  0.488
1982 Fukushima M, Kato T, Ueda R, Ota K, Narumiya S, Hayaishi O. Prostaglandin D2, a potential antineoplastic agent. Biochemical and Biophysical Research Communications. 105: 956-64. PMID 6953969 DOI: 10.1016/0006-291X(82)91063-4  0.435
1982 Kinoshita F, Nakai Y, Katakami H, Imura H, Shimizu T, Hayaishi O. Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. Endocrinology. 110: 2207-9. PMID 6951712 DOI: 10.1210/endo-110-6-2207  0.275
1982 Watanabe T, Narumiya S, Shimizu T, Hayaishi O. Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. The Journal of Biological Chemistry. 257: 14847-53. PMID 6816798  0.443
1982 Ueno R, Shimizu T, Kondo K, Hayaishi O. Activation mechanism of prostaglandin endoperoxide synthetase by hemoproteins. The Journal of Biological Chemistry. 257: 5584-8. PMID 6802818  0.349
1982 Shimizu T, Yamashita A, Hayaishi O. Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. The Journal of Biological Chemistry. 257: 13570-5. PMID 6292197  0.282
1982 Ueda K, Ogata N, Kawaichi M, Inada S, Hayaishi O. ADP-ribosylation reactions. Current Topics in Cellular Regulation. 21: 175-87. PMID 6291854  0.201
1982 Yoshida R, Hayaishi O. [Rhythms and physiological significance of indoleamine 2,3-dioxygenase (author's transl)]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 27: 143-51. PMID 6175995  0.201
1981 Kawaichi M, Oka J, Ueda K, Hayaishi O. A new method for oligo (ADP-ribose) fractionation according to chain length. Biochemical and Biophysical Research Communications. 101: 672-9. PMID 7306102  0.209
1981 Ito S, Takai K, Tokuyama T, Hayaishi O. Enzymatic modification of tryptophan residues by tryptophan side chain oxidase I and II from Pseudomonas. The Journal of Biological Chemistry. 256: 7834-43. PMID 7263628  0.262
1981 Kondo K, Shimizu T, Hayaishi O. Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye. Biochemical and Biophysical Research Communications. 98: 648-55. PMID 7225118 DOI: 10.1016/0006-291X(81)91163-3  0.229
1981 Shimizu T, Kondo K, Hayaishi O. Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. Archives of Biochemistry and Biophysics. 206: 271-6. PMID 7224637 DOI: 10.1016/0003-9861(81)90091-6  0.24
1981 Ogata N, Ueda K, Hayaishi O. Synthesis of [ribose (NMN)-14C]nicotinamide adenine dinucleotide from D-[14C]glucose. Analytical Biochemistry. 115: 58-60. PMID 7030128  0.231
1981 Yoshida R, Urade Y, Nakata K, Watanabe Y, Hayaishi O. Specific induction of indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide in the mouse lung. Archives of Biochemistry and Biophysics. 212: 629-37. PMID 6976775  0.203
1981 Watanabe Y, Yoshida R, Sono M, Hayaishi O. Immunohistochemical localization of indoleamine 2,3-dioxygenase in the argyrophilic cells of rabbit duodenum and thyroid gland. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 29: 623-32. PMID 6788834 DOI: 10.1177/29.5.6788834  0.38
1981 Kawaichi M, Ueda K, Hayaishi O. Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase. The Journal of Biological Chemistry. 256: 9483-9. PMID 6270088  0.261
1981 Ogata N, Ueda K, Kawaichi M, Hayaishi O. Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei. The Journal of Biological Chemistry. 256: 4135-7. PMID 6260786  0.289
1981 Sayama S, Yoshida R, Oku T, Imanishi J, Kishida T, Hayaishi O. Inhibition of interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung by inhibitors of prostaglandin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 78: 7327-30. PMID 6174971 DOI: 10.1073/Pnas.78.12.7327  0.399
1981 Yoshida R, Imanishi J, Oku T, Kishida T, Hayaishi O. Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. Proceedings of the National Academy of Sciences of the United States of America. 78: 129-32. PMID 6165986 DOI: 10.1073/Pnas.78.1.129  0.423
1980 Ogata N, Ueda K, Hayaishi O. ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. The Journal of Biological Chemistry. 255: 7610-5. PMID 7400135  0.238
1980 Ikai K, Ueda K, Fukushima M, Nakamura T, Hayaishi O. Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. 77: 3682-5. PMID 6997880 DOI: 10.1073/pnas.77.6.3682  0.342
1980 Ikai K, Ueda K, Hayaishi O. Immunohistochemical demonstration of poly(adenosine diphosphate-ribose) in nuclei of various rat tissues Journal of Histochemistry and Cytochemistry. 28: 670-676. PMID 6993553 DOI: 10.1177/28.7.6993553  0.392
1980 Watanabe Y, Fujiwara M, Yoshida R, Hayaishi O. Stereospecificity of hepatic L-tryptophan 2,3-dioxygenase. The Biochemical Journal. 189: 393-405. PMID 6783035  0.335
1980 Ogata N, Ueda K, Kagamiyama H, Hayaishi O. ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites. The Journal of Biological Chemistry. 255: 7616-20. PMID 6772638  0.238
1980 Shizuta Y, Ito S, Nakata K, Hayaishi O. [25] Poly(ADP-ribose) synthetase from calf thymus Methods in Enzymology. 66: 159-165. PMID 6246389 DOI: 10.1016/0076-6879(80)66455-6  0.419
1980 Okayama H, Ueda K, Hayaishi O. [24] Poly(ADP-ribose) synthetase from rat liver nuclei Methods in Enzymology. 66: 154-158. PMID 6246388 DOI: 10.1016/0076-6879(80)66454-4  0.426
1980 Okayama H, Ueda K, Hayaishi O. [23] NAD glycohydrolases from rat liver nuclei Methods in Enzymology. 66: 151-154. PMID 6246387 DOI: 10.1016/0076-6879(80)66453-2  0.4
1980 Kawaichi M, Ueda K, Hayaishi O. Initiation of poly(ADP-ribosyl) histone synthesis by poly(ADP-ribose) synthetase Journal of Biological Chemistry. 255: 816-819. PMID 6243297  0.277
1979 Ushiro H, Takai K, Narumiya S, Ito S, Hayaishi O. Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase. The Journal of Biological Chemistry. 254: 11794-7. PMID 500674  0.439
1979 Fujiwara M, Shibata M, Nomiyama Y, Sugimoto T, Hirata F, Tokuyama T, Senoh S, Hayaishi O. Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine Proceedings of the National Academy of Sciences of the United States of America. 76: 1145-1149. PMID 312499 DOI: 10.1073/Pnas.76.3.1145  0.402
1979 Iwasaki Y, Kato Y, Ohgo S, Abe H, Imura H, Hirata F, Senoh S, Tokuyama T, Hayaishi O. Effects of indoleamines and their newly identified metabolites on prolactin release in rats. Endocrinology. 103: 254-8. PMID 311280 DOI: 10.1210/endo-103-1-254  0.348
1979 Yoshida R, Urade Y, Tokuda M, Hayaishi O. Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection Proceedings of the National Academy of Sciences of the United States of America. 76: 4084-4086. PMID 291064 DOI: 10.1073/Pnas.76.8.4084  0.365
1979 Shimizu T, Mizuno N, Amano T, Hayaishi O. Prostaglandin D2, a neuromodulator Proceedings of the National Academy of Sciences of the United States of America. 76: 6231-6234. PMID 230503 DOI: 10.1073/Pnas.76.12.6231  0.399
1979 Ito S, Shizuta Y, Hayaishi O. Purification and characterization of poly(ADP-ribose) synthetase from calf thymus Journal of Biological Chemistry. 254: 3647-3651. PMID 218977  0.309
1979 Narumiya S, Takai K, Tokuyama T, Noda Y, Ushiro H, Hayaishi O. A new metabolic pathway of tryptophan initiated by tryptophan side chain oxidase. The Journal of Biological Chemistry. 254: 7007-15. PMID 110802  0.423
1979 SUDA M, HAYAISHI O, NAKAGAWA H. Biological Rhythms and Their Central Mechanism The Annual of Animal Psychology. 29: 105-106. DOI: 10.2502/janip1944.29.105  0.204
1978 Ushiro H, Takai K, Noda Y, Narumiya S, Tokuyama T, Hayaishi O. Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol. The Journal of Biological Chemistry. 253: 9002-8. PMID 721824  0.407
1978 Okayama H, Hayaishi O. ADP-ribosylation of nuclear protein A24 Biochemical and Biophysical Research Communications. 84: 755-762. PMID 718716 DOI: 10.1016/0006-291X(78)90769-6  0.237
1978 Yoshida R, Hayaishi O. Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 75: 3998-4000. PMID 279015 DOI: 10.1073/Pnas.75.8.3998  0.42
1978 Okayama H, Honda M, Hayaishi O. Novel enzyme from rat liver that cleaves an ADP-ribosyl histone linkage. Proceedings of the National Academy of Sciences of the United States of America. 75: 2254-2257. PMID 276865 DOI: 10.1073/Pnas.75.5.2254  0.433
1978 Okayama H, Ueda K, Hayaishi O. Purification of ADP-ribosylated nuclear proteins by covalent chromatography on dihydroxyboryl polyacrylamide beads and their characterization Proceedings of the National Academy of Sciences of the United States of America. 75: 1111-1115. PMID 274702  0.278
1978 Hayaishi O, Yoshida R. Specific induction of pulmonary indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide Ciba Foundation Symposium. 199-203. PMID 258162  0.315
1978 Noda Y, Takai K, Tokuyama T, Narumiya S, Ushiro H, Hayaishi O. Tryptophan side chain oxidase from Pseudomonas. pH-dependent formation of alpha,beta-didehydro, beta-hydroxy, and beta-keto derivatives of N-acetyltryptophanamide. The Journal of Biological Chemistry. 253: 4819-22. PMID 27505  0.418
1977 Noda Y, Takai K, Tokuyama T, Narumiya S, Ushiro H, Hayaishi O. Enzymatic oxidation of acetyltryptophanamide- and tryptophan-containing peptides. Formation of dehydrotryptophan. The Journal of Biological Chemistry. 252: 4413-5. PMID 863932  0.396
1977 Ohki S, Ogino N, Yamamoto S, Hayaishi O, Yamamoto H. Inhibition of prostaglandin endoperoxide synthetase by thiol analogues of prostaglandin. Proceedings of the National Academy of Sciences of the United States of America. 74: 144-8. PMID 402003 DOI: 10.1073/pnas.74.1.144  0.387
1977 Yui Y, Watanabe Y, Ito S, Shizuta Y, Hayaishi O. Multivalent Induction of Biodegradative Threonine Deaminase Journal of Bacteriology. 132: 363-369. PMID 334736 DOI: 10.1128/Jb.132.2.363-369.1977  0.43
1977 Hayaishi O, Ueda K. Poly(ADP-ribose) and ADP-ribosylation of proteins Annual Review of Biochemistry. 46: 95-116. PMID 197884  0.232
1977 Taniguchi T, Hirata F, Hayaishi O. Intracellular utilization of superoxide anion by indoleamine 2,3 dioxygenase of rabbit enterocytes Journal of Biological Chemistry. 252: 2774-2776. PMID 192720  0.275
1976 Okuma M, Tokuyama T, Senoh S, Hirata F, Hayaishi O. Antagonism of 5-hydroxykynurenamine against serotonin action on platelet aggregation. Proceedings of the National Academy of Sciences of the United States of America. 73: 643-645. PMID 1061163 DOI: 10.1073/Pnas.73.2.643  0.33
1976 Hayaishi O. Properties and function of indoleamine 2,3 dioxygenase Journal of Biochemistry. 79. PMID 931956  0.188
1976 Shizuta Y, Hayaishi O. Regulation of biodegradative threonine deaminase Current Topics in Cellular Regulation. 11: 99-146. PMID 187387  0.215
1976 Ishimura Y, Hayaishi O. On the prosthetic groups of L-tryptophan 2,3-dioxygenase from Pseudomonas: evidence for noninvolvement of copper in the reaction Advances in Experimental Medicine and Biology. 74: 363-373. PMID 183474  0.284
1976 Hayaishi O. Poly ADP-ribose and ADP-ribosylation of proteins Trends in Biochemical Sciences. 1: 9-10. DOI: 10.1016/0968-0004(76)90255-3  0.239
1975 Hayaishi O. Indoleamine 2,3 dioxygenase. A new vista in tryptophan metabolism Acta Vitaminologica Et Enzymologica. 29: 17-20. PMID 1244087  0.222
1975 Yamauchi T, Yamamoto S, Hayaishi O. A possible involvement of sulfhydryl groups in the conversion of lysine monooxygenase to an oxidase Journal of Biological Chemistry. 250: 7127-7133. PMID 1165238  0.341
1975 Hirata F, Hayaishi O. Studies on indoleamine 2,3 dioxygenase. I. Superoxide anion as substrate Journal of Biological Chemistry. 250: 5960-5966. PMID 238993  0.308
1975 Ueda K, Omachi A, Kawaichi M, Hayaishi O. Natural occurrence of poly(ADP-ribosyl) histones in rat liver Proceedings of the National Academy of Sciences of the United States of America. 72: 205-209. PMID 164015 DOI: 10.1073/Pnas.72.1.205  0.397
1975 UEDA K, OKAYAMA H, FUKUSHIMA M, HAYAISHI O. Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine1 The Journal of Biochemistry. 77: 1-1. DOI: 10.1093/oxfordjournals.jbchem.a130857  0.241
1975 Hayaishi O, Nozaki M, Abbott MT. 3 Oxygenases: Dioxygenases Enzymes. 12: 119-189. DOI: 10.1016/S1874-6047(08)60226-7  0.388
1974 Toda N, Tokuyama T, Senoh S, Hirata F, Hayaishi O. Effects of 5-Hydroxykynurenamine, a New Serotonin Metabolite, on Isolated Dog Basilar Arteries Proceedings of the National Academy of Sciences of the United States of America. 71: 122-124. PMID 4521045 DOI: 10.1073/Pnas.71.1.122  0.328
1974 Takai K, Kurashina Y, Hayaishi O. Adenylate cyclase from Brevibacterium liquefaciens. Methods in Enzymology. 38: 160-9. PMID 4453188 DOI: 10.1016/0076-6879(74)38025-1  0.412
1974 Hayaishi O. Enzymes of microorganisms-with special reference to adenylate cyclase Japanese Journal of Bacteriology. 29: 729-741. PMID 4374562  0.316
1974 Umezawa K, Takai K, Tsuji S, Kurashina Y, Hayaishi O. Adenylate cyclase from Brevibacterium liquefaciens. III. In situ regulation of adenylate cyclase by pyruvate. Proceedings of the National Academy of Sciences of the United States of America. 71: 4598-601. PMID 4373721 DOI: 10.1073/Pnas.71.11.4598  0.418
1974 Hayaishi O. Bacterial enzymology: adenylate cyclase Japanese Journal of Bacteriology. 29: 30. PMID 4365638  0.218
1974 Miyamoto T, Yamamoto S, Hayaishi O. Prostaglandin synthetase system: resolution into oxygenase and isomerase components Proceedings of the National Academy of Sciences of the United States of America. 71: 3645-3648. PMID 4215082 DOI: 10.1073/Pnas.71.9.3645  0.401
1974 Hayaishi O. History of Biochemistry. (Book Reviews: Development of Biochemical Concepts from Ancient to Modern Times) Science. 185: 936-937. DOI: 10.1126/Science.185.4155.936  0.303
1973 Honjo T, Hayaishi O. Enzymatic ADP-ribosylation of proteins and regulation of cellular activity Current Topics in Cellular Regulation. 7: 87-127. PMID 4360798 DOI: 10.1016/B978-0-12-152807-2.50011-5  0.564
1973 Ishimura Y, Hayaishi O. Noninvolvement of copper in the L tryptophan 2,3 dioxygenase reaction Journal of Biological Chemistry. 248: 8610-8612. PMID 4202780  0.205
1972 Tokushige M, Hayaishi O. Threonine metabolism and its regulation in Clostridium tetanomorphum Journal of Biochemistry. 72: 469-477. PMID 4644309  0.313
1972 Nakazawa T, Hori K, Hayaishi O. Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase Journal of Biological Chemistry. 247: 3439-3444. PMID 4624115  0.261
1972 Hirata F, Hayaishi O. New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase Biochemical and Biophysical Research Communications. 47: 1112-1119. PMID 4537396 DOI: 10.1016/0006-291X(72)90949-7  0.278
1972 Yamamoto S, Yamauchi T, Hayaishi O. Alkylamine-dependent amino-acid oxidation by lysine monooxygenase--fragmented substrate of oxygenase Proceedings of the National Academy of Sciences of the United States of America. 69: 3723-3726. PMID 4509334 DOI: 10.1073/Pnas.69.12.3723  0.388
1972 Kajita Y, Hayaishi O. Effect of prostaglandin E1 on the induction of rat liver tyrosine aminotransferase Bba - General Subjects. 261: 281-283. PMID 4401086 DOI: 10.1016/0304-4165(72)90339-X  0.307
1972 Miyakawa N, Ueda K, Hayaishi O. Association of poly ADP-ribose glycohydrolase with liver chromatin. Biochemical and Biophysical Research Communications. 49: 239-45. PMID 4342723 DOI: 10.1016/0006-291X(72)90035-6  0.224
1971 Hirata F, Hayaishi O. Possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction Journal of Biological Chemistry. 246: 7825-7826. PMID 5002685  0.204
1971 Hayaishi O, Okamoto H. Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase American Journal of Clinical Nutrition. 24: 805-806. PMID 4397476  0.204
1971 Honjo T, Nishizuka Y, Kato I, Hayaishi O. Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. The Journal of Biological Chemistry. 246: 4251-60. PMID 4326212  0.623
1971 Ide M, Tokushige M, Hayaishi O. Reversible inactivation of phosphofructokinase from Brevibacterium liquefaciens Archives of Biochemistry and Biophysics. 146: 361-363. PMID 4259268 DOI: 10.1016/S0003-9861(71)80077-2  0.232
1971 Nozaki M, Hayaishi O. Chapter VI Separation and Purification of Proteins Methods in Microbiology. 5: 425-454. DOI: 10.1016/S0580-9517(08)70644-5  0.205
1971 Nishizuka Y, Ueda K, Hayaishi O. [130] Adenosine diphosphoribosyltransferase in chromatin Methods in Enzymology. 18: 230-233. DOI: 10.1016/S0076-6879(71)18087-1  0.669
1971 Nishizuka Y, Hayaishi O. [120] Picolinic car{ballot box}ylase in reference to NAD biosynthesis Methods in Enzymology. 18: 162-175. DOI: 10.1016/S0076-6879(71)18077-9  0.674
1971 Nishizuka Y, Hayaishi O. [116] Mammalian pyridine ribonucleoside phosphokinase Methods in Enzymology. 18: 141-144. DOI: 10.1016/S0076-6879(71)18073-1  0.677
1970 Ono K, Nozaki M, Hayaishi O. Purification and some properties of protocatechuate 4,5-dioxygenase Bba - Enzymology. 220: 224-238. PMID 5487881 DOI: 10.1016/0005-2744(70)90008-2  0.314
1970 Okamoto H, Hayaishi O. Intramitochondrial localization of kynurenine aminotransferase Journal of Biological Chemistry. 245: 3603-3605. PMID 5470826  0.184
1970 Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O. Enzymic studies on the biosynthesis of serotonin in mammalian brain. The Journal of Biological Chemistry. 245: 1699-709. PMID 5309585  0.643
1970 Hayaishi O, Shizuta Y. Binding of pyridoxal phosphate to apoenzymes as studied by optical rotatory dispersion and circular dichroism Vitamins and Hormones. 28: 245-264. PMID 4946802  0.203
1970 Honjo T, Hayaishi O. Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 15: 515-523. PMID 4913828  0.203
1970 Shizuta Y, Hayaishi O. Regulation of threonine metabolism by adenine nucleotides Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 15: 1342-1353. PMID 4320218  0.233
1970 Shizuta Y, Hayaishi O. Regulation of biodegradative threonine deaminase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate Journal of Biological Chemistry. 245: 5416-5423. PMID 4319241  0.277
1970 Kobayashi S, Hayaishi O. [61] Anthranilic acid conversion to catechol (pseudomonas) Methods in Enzymology. 17: 505-510. DOI: 10.1016/0076-6879(71)17231-X  0.426
1970 Nishizuka Y, Ichiyama A, Hayaishi O. [58] Metabolism of the benzene ring of tryptophan (mammals) Methods in Enzymology. 17: 463-491. DOI: 10.1016/0076-6879(71)17228-X  0.677
1970 Yamamoto S, Hayaishi O. [53] Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rabbit intestine) Methods in Enzymology. 17: 434-438. DOI: 10.1016/0076-6879(71)17223-0  0.428
1969 Hayaishi O. Electronic aspects of catalysis of the oxygenases Annals of the New York Academy of Sciences. 158: 318-335. PMID 5256965  0.186
1969 Hayaishi O. Enzymic hydroxylation Annual Review of Biochemistry. 38: 21-44. PMID 4389914  0.314
1969 Nishizuka Y, Ueda K, Yoshihara K, Yamamura H, Takeda M, Hayaishi O. Enzymic adenosine diphosphoribosylation of nuclear proteins. Cold Spring Harbor Symposia On Quantitative Biology. 34: 781-6. PMID 4314921 DOI: 10.1101/Sqb.1969.034.01.088  0.666
1969 Honjo T, Nishizuka Y, Hayaishi O. Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. Cold Spring Harbor Symposia On Quantitative Biology. 34: 603-8. PMID 4314916 DOI: 10.1101/Sqb.1969.034.01.069  0.717
1969 Hayaishi O, Nozaki M. Nature and mechanisms of oxygenases Science. 164: 389-396. PMID 4304952 DOI: 10.1126/Science.164.3878.389  0.311
1969 Okamoto H, Hayaishi O. Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors Archives of Biochemistry and Biophysics. 131: 603-608.  0.254
1968 Nakazawa K, Ueda K, Honjo T, Yoshihara K, Nishizuka Y, Hayaishi O. Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. Biochemical and Biophysical Research Communications. 32: 143-9. PMID 5672131 DOI: 10.1016/0006-291X(68)90360-4  0.718
1968 Ueda K, Reeder RH, Honjo T, Nishizuka Y, Hayaishi O. Poly adenosine diphosphate ribose synthesis associated with chromatin. Biochemical and Biophysical Research Communications. 31: 379-85. PMID 5653649 DOI: 10.1016/0006-291X(68)90486-5  0.706
1968 Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O. Tryptophan-5-hydroxylase in mammalian brain. Advances in Pharmacology. 6: 5-17. PMID 5302021  0.608
1968 Fujisawa H, Hayaishi O. Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization Journal of Biological Chemistry. 243: 2673-2681. PMID 4967959  0.178
1968 Deguchi T, Ichiyama A, Nishizuka Y, Hayaishi O. Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain. Biochimica Et Biophysica Acta. 158: 382-93. PMID 4298234 DOI: 10.1016/0304-4165(68)90292-4  0.655
1968 Nishizuka Y, Ueda K, Honjo T, Hayaishi O. Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. The Journal of Biological Chemistry. 243: 3765-7. PMID 4298073  0.647
1968 Honjo T, Nishizuka Y, Hayaishi O. Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. The Journal of Biological Chemistry. 243: 3553-5. PMID 4297784  0.625
1968 Yamazaki M, Hayaishi O. Allosteric properties of nucleoside diphosphatase and its identity with thiamine pyrophosphatase Journal of Biological Chemistry. 243: 2934-2942. PMID 4297466  0.224
1968 Okamoto H, Nozaki M, Hayaishi O. A role of sulfhydryl groups in imidazoleacetate monooxygenase Biochemical and Biophysical Research Communications. 32: 30-36.  0.192
1967 Yamamoto S, Hayaishi O. Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes Journal of Biological Chemistry. 242: 5260-5266. PMID 6065097  0.326
1967 Ishimura Y, Nozaki M, Hayaishi O. Evidence for an oxygenated intermediate in the tryptophan pyrrolase reaction Journal of Biological Chemistry. 242: 2574-2576. PMID 6026250  0.206
1967 Nakazawa A, Hayaishi O. On the mechanism of activation of L-threonine deaminase from Clostridium tetanomorphum by adenosine diphosphate Journal of Biological Chemistry. 242: 1146-1154. PMID 6023568  0.245
1967 Nakazawa A, Tokushige M, Hayaishi O. Circular dichroism of biodegradative threonine deaminase Biochemical and Biophysical Research Communications. 29: 184-188. PMID 4864068  0.293
1967 Tokushige M, Hayaishi O, Morita K. Reactivating effect of some naturally occurring dithiol compounds on threonine deaminase Archives of Biochemistry and Biophysics. 122: 522-523. PMID 4864065 DOI: 10.1016/0003-9861(67)90231-7  0.311
1967 Hayaishi O, Ijichi H, Ichiyama A. Studies on the biosynthesis of nad by a direct method of tracing metabolism in vivo Advances in Enzyme Regulation. 5: 9-22. PMID 4301796  0.271
1967 Hirata M, Hayaishi O. Adenyl cyclase of Brevibacterium liquefaciens Bba Section Nucleic Acids and Protein Synthesis. 149: 1-11. PMID 4295782  0.313
1967 Ohtsu E, Ichiyama A, Nishizuka Y, Hayaishi O. Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms. Biochemical and Biophysical Research Communications. 29: 635-41. PMID 4294854  0.619
1967 Higuchi K, Hayaishi O. Enzymic formation of d-kynurenine from d-tryptophan Archives of Biochemistry and Biophysics. 120: 397-403. PMID 4291827  0.334
1967 Reeder RH, Ueda K, Honjo T, Nishizuka Y, Hayaishi O. Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. The Journal of Biological Chemistry. 242: 3172-9. PMID 4291073  0.591
1967 Nishizuka Y, Ueda K, Nakazawa K, Hayaishi O. Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei. The Journal of Biological Chemistry. 242: 3164-71. PMID 4291072  0.635
1967 Okamoto H, Hayaishi O. Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria Biochemical and Biophysical Research Communications. 29: 394-399.  0.253
1966 Nishizuka Y, Hayaishi O, Morris HP. Cancer research: u. S.-Japan cooperative science program. Science (New York, N.Y.). 152: 1524-6. PMID 17788034 DOI: 10.1126/Science.152.3728.1524  0.607
1966 Hirata M, Hayaishi O. Enzymic formation of deoxyadenosine 3′,5′-phosphate Biochemical and Biophysical Research Communications. 24: 360-364. PMID 5967096  0.31
1966 Takeda H, Hayaishi O. Crystalline L-lysine oxygenase Journal of Biological Chemistry. 241: 2733-2736. PMID 5911646  0.206
1966 Hayaishi O. Crystalline oxygenases of pseudomonads Bacteriological Reviews. 30: 720-731. PMID 5342517  0.202
1966 Hayaishi O. Oxygenases [Zasshi] Journal. Nihon Naika Gakkai. 55: 741-752. PMID 5342007  0.249
1966 Honjo T, Nakamura S, Nishizuka Y, Hayaishi O. Stoichiometric utilization of adenosine 5'-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl-1-pyrophosphate. Biochemical and Biophysical Research Communications. 25: 199-204. PMID 4291351 DOI: 10.1016/0006-291X(66)90580-8  0.697
1966 Hayaishi O. Advances in enzymology in urology Japanese Journal of Urology. 57: 939-944. PMID 4289006  0.177
1966 Hayaishi O. Enzymic studies on the mechanism of double hydroxylation Pharmacological Reviews. 18: 71-75. PMID 4285737  0.308
1966 Hayaishi O. [16] Lactose dehydrogenase Methods in Enzymology. 9: 73-78. DOI: 10.1016/0076-6879(66)09020-7  0.404
1965 YAMAZAKI M, HAYAISHI O. THE ACTIVATION OF NUCLEOSIDE DIPHOSPHATASE BY NUCLEOSIDE TRIPHOSPHATES The Journal of Biological Chemistry. 240: 2761-2762. PMID 14304898  0.25
1965 IKEDA M, TSUJI H, NAKAMURA S, ICHIYAMA A, NISHIZUKA Y, HAYAISHI O. STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS. The Journal of Biological Chemistry. 240: 1395-401. PMID 14284754  0.624
1965 ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O, SENOH S. STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID. The Journal of Biological Chemistry. 240: 740-9. PMID 14275130  0.642
1965 NISHIZUKA Y, ICHIYAMA A, GHOLSON RK, HAYAISHI O. STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID. The Journal of Biological Chemistry. 240: 733-9. PMID 14275129  0.642
1965 HAYAISHI O. ENZYMES AND MEDICINE Current Therapeutic Research, Clinical and Experimental. 13: 66-84. PMID 14246373  0.303
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