☰

Mark L. McLaughlin, Ph.D. - Publications

Affiliations: 
1986-2002 Chemistry Louisiana State University, Baton Rouge, LA, United States 
 2002-2016 Chemistry University of South Florida, Tampa, FL, United States 
Area:
Medicinal chemistry, oncology
Website:
http://directory.hsc.wvu.edu/Individual/Index/45305
Tree Info Similar researchers PubMed Report error

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jain P, Badger DB, Liang Y, Gebhard AW, Santiago D, Murray P, Kaulagari SR, Gauthier TJ, Nair R, Kumar M, Guida WC, Hazlehurst LA, McLaughlin ML. Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101. Peptide Science (Hoboken, N.J.). 113: e24199. PMID 35859761 DOI: 10.1002/pep2.24199  0.683
2017 Barber C, Antonucci V, Baumann JC, Brown R, Covey-Crump E, Elder D, Elliott E, Fennell JW, Gallou F, Ide ND, Jordine G, Kallemeyn JM, Lauwers D, Looker AR, Lovelle LE, ... McLaughlin M, et al. A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies. Regulatory Toxicology and Pharmacology : Rtp. PMID 28822875 DOI: 10.1016/j.yrtph.2017.08.008  0.481
2013 Gebhard AW, Jain P, Nair RR, Emmons MF, Argilagos RF, Koomen JM, McLaughlin ML, Hazlehurst LA. MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. Molecular Cancer Therapeutics. 12: 2446-58. PMID 24048737 DOI: 10.1158/1535-7163.Mct-13-0310  0.665
2012 Drake BL, Morris JL, McLaughlin ML, Fronczek FR, Watkins SF. Tetra-methyl anthracene-2,3,6,7-tetra-carboxyl-ate-tetra-methyl 9,10-dihydro-9,10-dioxoanthracene-2,3,6,7-tetra-carboxyl-ate (1/1). Acta Crystallographica. Section E, Structure Reports Online. 68: o2540-1. PMID 22904973 DOI: 10.1107/S1600536812032424  0.325
2011 Phelan WA, Ngu-Schwemlein M, Fronczek FR, McLaughlin ML, Watkins SF. 1,2-Dihydro-9H-carbazole-4(3H)-thione. Acta Crystallographica. Section E, Structure Reports Online. 67: o757. PMID 21754054 DOI: 10.1107/S1600536811006623  0.354
2010 Fronczek CF, Kil H, McLaughlin ML, Fronczek FR. (S)-(Z)-Methyl 2-[2,3-bis-(benzyl-oxy-carbon-yl)guanidino]-4-methyl-penta-no-ate. Acta Crystallographica. Section E, Structure Reports Online. 67: o27-8. PMID 21522740 DOI: 10.1107/S1600536810050130  0.346
2010 Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics. The Journal of Organic Chemistry. 75: 4288-91. PMID 20469918 DOI: 10.1021/Jo100272D  0.755
2010 Sharma V, McLaughlin ML. Efficient assembly of 2,5,6-substituted pyrimidines via MgI(2)-mediated Morita-Baylis-Hillman reaction. Journal of Combinatorial Chemistry. 12: 327-31. PMID 20218627 DOI: 10.1021/Cc100001E  0.336
2009 Yi SW, Jain P, Ajmera M, Kaulagari SR, Topper M, Anderson L, McLaughlin ML. Cysteine based PNA (CPNA): design and synthesis of novel CPNA monomers. Advances in Experimental Medicine and Biology. 611: 553-4. PMID 19400310 DOI: 10.1007/978-0-387-73657-0_243  0.711
2009 Anderson L, Topper M, Jain P, McIntosh E, McLaughlin ML. Synthesis of N-Boc protected hydrazine diacids as key structural units for the formation of alpha-helix mimics. Advances in Experimental Medicine and Biology. 611: 211-2. PMID 19400164 DOI: 10.1007/978-0-387-73657-0_97  0.741
2008 Mokdad A, Belof JL, Yi SW, Shuler SE, McLaughlin ML, Space B, Larsen RW. Photophysical studies of the trans to cis isomerization of the push-pull molecule: 1-(pyridin-4-yl)-2-(N-methylpyrrol-2-yl)ethene (mepepy). The Journal of Physical Chemistry. A. 112: 8310-5. PMID 18700732 DOI: 10.1021/Jp803268R  0.544
2006 Weiss ST, McIntyre NR, McLaughlin ML, Merkler DJ. The development of molecular clamps as drugs. Drug Discovery Today. 11: 819-24. PMID 16935750 DOI: 10.1016/J.Drudis.2006.07.011  0.514
2006 Thalji RK, McLaughlin ML, Watkins SF, Fronczek FR. Di-tert-butyl 4-oxocyclohexane-1,1 -dicarboxylate Acta Crystallographica Section E: Structure Reports Online. 62: o2584-o2585. DOI: 10.1107/S1600536806019908  0.327
2005 Hammarström LGJ, Fu Y, Vail S, Hammer RP, McLaughlin ML. A Convenient Preparation of an Orthogonally Protected Cα,Cα‐Disubstituted Amino Acid Analog of Lysine: 1‐tert‐butyloxycarbonyl‐4‐((9‐fluorenylmethyloxycarbonyl)amino)‐piperidine‐4‐carboxylic Acid Organic Syntheses. 213-224. DOI: 10.1002/0471264229.Os081.23  0.315
2004 Fu Y, Zhou Z, Hazendonk P, Bain AD, Fronczek FR, Escobedo J, McLaughlin ML, Hammer RP. Solution and solid structure of a boc-protected piperidine-spiro-hydantoin as studied by two-dimensional NMR and X-ray crystallography Journal of Molecular Structure. 687: 65-72. DOI: 10.1016/J.Molstruc.2003.09.013  0.337
2003 Heathcock CH, McLaughlin M, Medina J, Hubbs JL, Wallace GA, Scott R, Claffey MM, Hayes CJ, Ott GR. Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2). Journal of the American Chemical Society. 125: 12844-9. PMID 14558833 DOI: 10.1021/Ja030317+  0.303
2003 Fronczek FR, Giraldés J, McLaughlin ML. Disordered syn-anti hydrogen-bonded chains in 3-(ferrocenylcarbonyl)propionic acid. Acta Crystallographica. Section C, Crystal Structure Communications. 59: m159-61. PMID 12743384 DOI: 10.1107/S0108270103006309  0.771
2003 Clark JC, Talele T, McLaughlin ML, Fronczek FR. (E)-3-Hexene-1,6-diyl dibenzoate Acta Crystallographica Section E: Structure Reports Online. 59: o962-o963. DOI: 10.1107/S1600536803012315  0.304
2002 Adams PD, Chen Y, Ma K, Zagorski MG, Sönnichsen FD, McLaughlin ML, Barkley MD. Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides. Journal of the American Chemical Society. 124: 9278-86. PMID 12149035 DOI: 10.1021/Ja0167710  0.327
2002 Giraldés J, McLaughlin ML, Fronczek FR. 1-Benzoyl-2(S)-tert-butyl-4-methoxy-6(S)-carbomethoxy-1,2,5,6-tetrahydro-1,3-pyrimidine: a useful precursor of α-alkylated aspartic acids Acta Crystallographica Section E Structure Reports Online. 58: o261-o262. DOI: 10.1107/S1600536802002210  0.783
2002 Oguz U, Guilbeau GG, McLaughlin ML. A facile stereospecific synthesis of α-hydrazino esters Tetrahedron Letters. 43: 2873-2875. DOI: 10.1016/S0040-4039(02)00352-0  0.757
2001 Fu Y, Hammarström LG, Miller TJ, Fronczek FR, McLaughlin ML, Hammer RP. Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides. The Journal of Organic Chemistry. 66: 7118-24. PMID 11597239 DOI: 10.1021/Jo015809O  0.354
2001 Hammarström LG, Gauthier TJ, Hammer RP, McLaughlin ML. Amphipathic control of the 3(10)-/alpha-helix equilibrium in synthetic peptides. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 108-16. PMID 11532070 DOI: 10.1034/J.1399-3011.2001.00858.X  0.75
2001 Giraldés J, McLaughlin ML, Fronczek FR. 2-Propenyl 4-ferrocenyl-4-oxobutanoate Acta Crystallographica Section E Structure Reports Online. 57: m426-m427. DOI: 10.1107/S1600536801014659  0.764
2000 Hammarström LG, Zhang T, Giraldés J, McLaughlin ML, Billodeaux DR, Fronczek FR. Two N-ortho-nitrobenzenesulfonyl alpha,alpha-disubstituted amino acid adducts. Acta Crystallographica. Section C, Crystal Structure Communications. 56: 1484-6. PMID 11118999 DOI: 10.1107/S0108270100012464  0.772
2000 Giraldés J, McLaughlin ML, Fronczek FR. N∊-Benzyloxycarbonyl-Nα-(2-nitrobenzenesulfonyl)-L-lysine Acta Crystallographica Section E Structure Reports Online. 57: o48-o49. DOI: 10.1107/S1600536800018961  0.767
2000 Oguz U, McLaughlin ML, Fronczek FR. 2-Nitro-N,N-bis(2-nitrophenylthio)benzenesulfonamide Acta Crystallographica Section C Crystal Structure Communications. 56: e27-e28. DOI: 10.1107/S0108270199016121  0.757
1998 Yokum TS, Bursavich MG, Gauthier T, Hammer RP, McLaughlin ML. 310-Helix stabilization via side-chain salt bridges Chemical Communications. 1801-1802. DOI: 10.1039/A805458D  0.748
1997 Gauthier TJ, Yokum TS, Morales GA, McLaughlin ML, Liu YH, Fronczek FR. Two cyclohexanespiro-5'-hydantoin monohydrates. Acta Crystallographica. Section C, Crystal Structure Communications. 53: 1659-61. PMID 9396146 DOI: 10.1107/S0108270197007488  0.741
1997 Dávila A, Mclaughlin ML, Fronczek FR, Watkins SF. 1,5-Dibromocycloocta-1,5-diene Acta Crystallographica Section C: Crystal Structure Communications. 53: 84-86. DOI: 10.1107/S0108270196012322  0.335
1997 Yokum TS, Gauthier TJ, Hammer RP, McLaughlin ML. Solvent effects on the 310-/α-helix equilibrium in short amphipathic peptides rich in α,α-disubstituted amino acids Journal of the American Chemical Society. 119: 1167-1168. DOI: 10.1021/Ja962875C  0.736
1997 Yokum TS, Tungaturthi PK, McLaughlin ML. Benz[f]tryptophan, a bathochromic analog of tryptophan, synthesis of its N-α-t-Boc derivative Tetrahedron Letters. 38: 5111-5114. DOI: 10.1016/S0040-4039(97)01139-8  0.319
1997 Yokum TS, Bursavich MG, Piha-Paul SA, Hall DA, McLaughlin ML. Synthesis of a series of polar, orthogonally protected, α,α-disubstituted amino acids Tetrahedron Letters. 38: 4013-4016. DOI: 10.1016/S0040-4039(97)00822-8  0.358
1996 Sánchez Peña M, Zhang Y, Thibodeaux S, McLaughlin ML, Muñoz De La Peña A, Warner IM. Synthesis of a water-soluble chiral N-acylcalix(4)arene amino acid derivative Tetrahedron Letters. 37: 5841-5844. DOI: 10.1016/0040-4039(96)01240-3  0.345
1996 Dávila A, Ramezanian MS, Fronczek FR, McLaughlin ML. 3 + 2 Cycloaddition via a Diels-Alder/retro-Diels-Alder sequence: Tandem cyclopentadienyl annulation of a 1,5-cyclooctadiyne synthetic equivalent Tetrahedron Letters. 37: 2517-2520. DOI: 10.1016/0040-4039(96)00384-X  0.301
1996 Nauman TR, McLaughlin ML, Fronczek FR, Watkins SF. The structure of a tetrabromotetrahydrodibenzocyclooctene Journal of Chemical Crystallography. 26: 107-110. DOI: 10.1007/Bf01669725  0.322
1995 Garcia JG, McLaughlin ML. Inverse-electron demand diels-alder cyclocondensations in the synthesis of 5-8-5 fused ring systems Organic Preparations and Procedures International. 27: 92-95. DOI: 10.1080/00304949509458183  0.764
1995 Morris JL, McLaughlin ML, Daly WH. A Novel Monomer and Polymers Based on 2,3,6,7-Anthracenetetracarboxylic Acid Macromolecules. 28: 3973-3979. DOI: 10.1021/Ma00115A033  0.325
1994 Garcia JG, Morales G, Fronczek FR, McLaughlin ML. The structures of endo-13-syn-methyltricyclo[8.2.1.02,9]trideca-5,11-dien-13-anti-ol, endo-13-syn-methyltricyclo[8.2.1.02,9]trideca-5,11-dien-13-anti-yl acetate and its corresponding endo-endo-anti Diels–Alder adducts with 1,2,3,4-tetrachloro-5,5-dimethoxy-1,3-cyclopentadiene and hexachlorocyclopentadiene Acta Crystallographica Section C Crystal Structure Communications. 50: 317-324. DOI: 10.1107/S0108270193007061  0.35
1993 Erickson MS, Fronczek FR, McLaughlin ML. Synthesis of 1,4-(1,1′-ferrocenediyl)-1,3-butadiene: A dieno-ferrocenophane. Tetrahedron Letters. 34: 197-198. DOI: 10.1016/S0040-4039(00)60545-2  0.302
1992 Erickson MS, Cronan JM, Garcia JG, McLaughlin ML. Syntheses of dipentafulvenes: Bichromophoric effects correlated with structure Journal of Organic Chemistry. 57: 2504-2508. DOI: 10.1021/Jo00034A061  0.746
1991 Garcia JG, Fronczek FR, McLaughlin ML. Pentacyclo[12.2.1.16,9.02,13.05,10] octadeca-7,15-diene-17,18-dione Acta Crystallographica Section C: Crystal Structure Communications. 47: 2009-2011. DOI: 10.1107/S0108270191002871  0.333
1991 Garcia JG, Fronczek FR, McLaughlin ML. Tricyclo[8.2.1.02,9]trideca-5,11-dien-13-one Acta Crystallographica Section C: Crystal Structure Communications. 47: 1998-2000. DOI: 10.1107/S010827019100286X  0.302
1991 Garcia JG, Fronczek FR, McLaughlin ML. endo–endo Diels–Alder diadduct of 5,5‐dimethoxy‐1,2,3,4‐tetrachloro‐1,3‐cyclopentadiene with 1,5‐cyclooctadiene, (1), and the dechlorinated Diels–Alder diadduct, (2) Acta Crystallographica Section C. 47: 206-209. DOI: 10.1107/S0108270190006965  0.308
1991 Garcia JG, Fronczek FR, McLaughlin ML. trans‐1,5‐Bicyclo[4.4.0]decadione Acta Crystallographica Section C. 47: 204-206. DOI: 10.1107/S0108270190006953  0.319
1991 Garcia JG, Fronczek FR, McLaughlin ML. (4S,5S)‐4,5‐Bis(pyrrolidinylcarbonyl)‐2,2‐dimethyl‐1,3‐dioxolane Acta Crystallographica Section C. 47: 202-204. DOI: 10.1107/S0108270190006941  0.311
1991 Garcia JG, McLaughlin ML. Reverse-electron-demand diels-alder dienophile π-face selectivity via conformation dependent transmission of π-σ-π electronic interactions. Tetrahedron Letters. 32: 3293-3296. DOI: 10.1016/S0040-4039(00)92689-3  0.754
1991 Garcia JG, Fronczek FR, McLaughlin ML. Tandem reverse-electron-demand diels-alder reactions of 1,5-cyclooctadiene. Tetrahedron Letters. 32: 3289-3292. DOI: 10.1016/S0040-4039(00)92688-1  0.755
1991 Erickson MS, Fronczek FR, McLaughlin ML. Stereoselectivity in the synthesis of tetramethylethano-bridged 3,3′-di-tert-butyltitanocene dichloride Journal of Organometallic Chemistry. 415: 75-85. DOI: 10.1016/0022-328X(91)83282-9  0.335
1990 Erickson MS, Fronczek FR, McLaughlin ML. The syn tetramethylethano-bridged 3,3'-di-tert-butyltitanocene dichloride Acta Crystallographica Section C Crystal Structure Communications. 46: 1802-1804. DOI: 10.1107/S0108270190001032  0.308
1990 Vela MA, Fronczek FR, Horn GW, McLaughlin ML. Syntheses of 1- and 2-naphthol analogues of DL-tyrosine. Potential fluorescent probes of peptide structure and dynamics in complex environments Journal of Organic Chemistry. 55: 2913-2918. DOI: 10.1021/Jo00296A064  0.318
1989 Fronczek FR, McLaughlin ML, Cronan Jnr JM. The mono Diels–Alder adduct of 1,4-bis(2,4-cyclopentadien-1-ylidene)cyclohexane and dimethyl butynedioate Acta Crystallographica Section C Crystal Structure Communications. 45: 1184-1186. DOI: 10.1107/S0108270189000740  0.308
1989 Vela MA, McLaughlin ML, Fronczek FR. An aminocyclohexanecarboxylic acid Acta Crystallographica Section C. 45: 1091-1093. DOI: 10.1107/S0108270189000284  0.305
1987 Paquette LA, Gugelchuk M, McLaughlin ML. Isodicyclopentadienes and related molecules. 38. Homochiral pinene-fused cyclopentadienes. Synthesis and .pi.-facially selective course of Diels-Alder cycloadditions and metallocene formation The Journal of Organic Chemistry. 52: 4732-4740. DOI: 10.1021/Jo00230A015  0.407
1986 Lewis ES, Mclaughlin ML, Douglas TA. Methyl Transfers. Part 10. The Marcus Equation Application to Soft Nucleophiles. Cheminform. 17. DOI: 10.1002/Chin.198610091  0.545
1985 Lewis ES, McLaughlin ML, Douglas TA. Methyl transfers. 10. The Marcus equation application to soft nucleophiles Journal of the American Chemical Society. 107: 6668-6673. DOI: 10.1021/Ja00309A040  0.558
1985 Lewis ES, Douglas TA, Mclaughlin ML. Methyl Transfer Reaction IX. Linear Free Energy Relations and the Reactivity—Selectivity Principle Israel Journal of Chemistry. 26: 331-338. DOI: 10.1002/Ijch.198500116  0.517
Show low-probability matches.