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Patricia M. Legler, Ph.D. - Publications

Affiliations: 
NRL 
 2002 Johns Hopkins University, Baltimore, MD 
Area:
SSHHPS/nsP, Post-translational Silencing, Viruses, Sequence-to-Symtpom
Website:
https://www.jove.com/author/Patricia+M._Legler
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bouknight KD, Jurkouich KM, Compton JR, Khavrutskii IV, Guelta MA, Harvey SP, Legler PM. Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A. Biochemical Pharmacology. 113980. PMID 32305437 DOI: 10.1016/J.Bcp.2020.113980  0.35
2019 Hu X, Compton JR, Legler PM. Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods. Journal of Visualized Experiments : Jove. PMID 31904018 DOI: 10.3791/60421  0.378
2019 Punde N, Kooken J, Leary D, Legler PM, Angov E. Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity. Amb Express. 9: 167. PMID 31630257 DOI: 10.1186/S13568-019-0890-6  0.345
2019 Khavrutskii IV, Compton JR, Jurkouich K, Legler PM. Paired Carboxylic Acids in Enzymes and their Role in Selective Substrate Binding, Catalysis, and Unusually Shifted pK Values. Biochemistry. PMID 31192586 DOI: 10.1021/Acs.Biochem.9B00429  0.473
2019 Morazzani EM, Compton JR, Leary DH, Berry AV, Hu X, Marugan J, Glass PJ, Legler PM. Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and zika virus. Antiviral Research. PMID 30742841 DOI: 10.1016/J.Antiviral.2019.02.001  0.319
2017 Compton J, Mickey M, Hu X, Marugan JJ, Legler PM. Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease leads to a Self-inhibited state. Biochemistry. PMID 29064679 DOI: 10.1021/Acs.Biochem.7B00746  0.444
2016 Legler PM, Compton JR, Hale ML, Anderson GP, Olson MA, Millard CB, Goldman ER. Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies. Mabs. 0. PMID 27660893 DOI: 10.1080/19420862.2016.1236882  0.365
2016 Hu X, Compton JR, Leary DH, Olson MA, Lee MS, Cheung J, Ye W, Ferrer M, Southall N, Jadhav A, Morazzani EM, Glass PJ, Marugan JJ, Legler PM. Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. Biochemistry. PMID 27030368 DOI: 10.1021/Acs.Biochem.5B00992  0.496
2016 Olson MA, Legler PM, Goldman ER. Comparison of Replica Exchange Simulations of a Kinetically Trapped Protein Conformational State and Its Native Form. The Journal of Physical Chemistry. B. PMID 26886055 DOI: 10.1021/Acs.Jpcb.6B00233  0.365
2015 Olson MA, Zabetakis D, Legler PM, Turner KB, Anderson GP, Goldman ER. Can template-based protein models guide the design of sequence fitness for enhanced thermal stability of single domain antibodies? Protein Engineering, Design & Selection : Peds. 28: 395-402. PMID 26374895 DOI: 10.1093/Protein/Gzv047  0.316
2015 Legler PM, Soojhawon I, Millard CB. A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime. Acta Crystallographica. Section D, Biological Crystallography. 71: 1788-98. PMID 26327369 DOI: 10.1107/S1399004715011281  0.393
2014 Zabetakis D, Olson MA, Anderson GP, Legler PM, Goldman ER. Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody. Plos One. 9: e115405. PMID 25526640 DOI: 10.1371/Journal.Pone.0115405  0.334
2014 Khavrutskii IV, Legler PM, Friedlander AM, Wallqvist A. A reaction path study of the catalysis and inhibition of the Bacillus anthracis CapD γ-glutamyl transpeptidase. Biochemistry. 53: 6954-67. PMID 25334088 DOI: 10.1021/Bi500623C  0.426
2014 George J, Compton JR, Leary DH, Olson MA, Legler PM. Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins. 82: 3101-16. PMID 25136772 DOI: 10.1002/Prot.24671  0.393
2014 Legler PM, Boisvert SM, Compton JR, Millard CB. Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase. Frontiers in Chemistry. 2: 46. PMID 25077141 DOI: 10.3389/Fchem.2014.00046  0.365
2014 Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. Journal of Computer-Aided Molecular Design. 28: 765-78. PMID 24958623 DOI: 10.1007/S10822-014-9758-7  0.339
2014 Turner KB, Zabetakis D, Legler P, Goldman ER, Anderson GP. Isolation and epitope mapping of staphylococcal enterotoxin B single-domain antibodies. Sensors (Basel, Switzerland). 14: 10846-63. PMID 24949641 DOI: 10.3390/S140610846  0.317
2013 Hu X, Compton JR, Abdulhameed MD, Marchand CL, Robertson KL, Leary DH, Jadhav A, Hershfield JR, Wallqvist A, Friedlander AM, Legler PM. 3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening. Journal of Medicinal Chemistry. 56: 5275-87. PMID 23815100 DOI: 10.1021/Jm4001242  0.388
2013 Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER. Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 90-3. PMID 23385744 DOI: 10.1107/S1744309112050750  0.327
2013 Janosi L, Compton JR, Legler PM, Steele KE, Davis JM, Matyas GR, Millard CB. Disruption of the putative vascular leak peptide sequence in the stabilized ricin vaccine candidate RTA1-33/44-198. Toxins. 5: 224-48. PMID 23364220 DOI: 10.3390/Toxins5020224  0.411
2012 Legler PM, Leary DH, Hervey WJ, Millard CB. A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: evidence for an oxidation sensitive motif. Archives of Biochemistry and Biophysics. 528: 7-20. PMID 22906720 DOI: 10.1016/J.Abb.2012.08.001  0.392
2012 Anderson GP, Legler PM, Zabetakis D, Goldman ER. Comparison of immunoreactivity of staphylococcal enterotoxin B mutants for use as toxin surrogates. Analytical Chemistry. 84: 5198-203. PMID 22681495 DOI: 10.1021/Ac300864J  0.361
2012 Hu X, Legler PM, Khavrutskii I, Scorpio A, Compton JR, Robertson KL, Friedlander AM, Wallqvist A. Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase. Biochemistry. 51: 1199-212. PMID 22257032 DOI: 10.1021/Bi200987B  0.417
2012 Khan F, Legler PM, Mease RM, Duncan EH, Bergmann-Leitner ES, Angov E. Histidine affinity tags affect MSP1(42) structural stability and immunodominance in mice. Biotechnology Journal. 7: 133-47. PMID 22076863 DOI: 10.1002/Biot.201100331  0.316
2011 Legler PM, Brey RN, Smallshaw JE, Vitetta ES, Millard CB. Structure of RiVax: a recombinant ricin vaccine. Acta Crystallographica. Section D, Biological Crystallography. 67: 826-30. PMID 21904036 DOI: 10.1107/S0907444911026771  0.316
2011 Compton JR, Legler PM, Clingan BV, Olson MA, Millard CB. Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen. Proteins. 79: 1048-60. PMID 21387408 DOI: 10.1002/Prot.22933  0.391
2008 Legler PM, Kumaran D, Swaminathan S, Studier FW, Millard CB. Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase. Biochemistry. 47: 9592-601. PMID 18707125 DOI: 10.1021/Bi8010016  0.451
2006 Mildvan AS, Xia Z, Azurmendi HF, Legler PM, Balfour MR, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM. Hydrogen bonding in the mechanism of GDP-mannose mannosyl hydrolase Journal of Molecular Structure. 790: 160-167. DOI: 10.1016/J.Molstruc.2005.09.024  0.622
2005 Mildvan AS, Xia Z, Azurmendi HF, Saraswat V, Legler PM, Massiah MA, Gabelli SB, Bianchet MA, Kang LW, Amzel LM. Structures and mechanisms of Nudix hydrolases. Archives of Biochemistry and Biophysics. 433: 129-43. PMID 15581572 DOI: 10.1016/J.Abb.2004.08.017  0.621
2004 Legler PM, Cai M, Peterkofsky A, Clore GM. Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system. The Journal of Biological Chemistry. 279: 39115-21. PMID 15258141 DOI: 10.1074/Jbc.M406764200  0.394
2002 Legler PM, Massiah MA, Mildvan AS. Mutational, kinetic, and NMR studies of the mechanism of E. coli GDP-mannose mannosyl hydrolase, an unusual Nudix enzyme. Biochemistry. 41: 10834-48. PMID 12196023 DOI: 10.1021/Bi020362E  0.659
2002 Legler PM, Lee HC, Peisach J, Mildvan AS. Kinetic and magnetic resonance studies of the role of metal ions in the mechanism of Escherichia coli GDP-mannose mannosyl hydrolase, an unusual nudix enzyme. Biochemistry. 41: 4655-68. PMID 11926828 DOI: 10.1021/Bi012118D  0.615
2000 Legler PM, Massiah MA, Bessman MJ, Mildvan AS. GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases. Biochemistry. 39: 8603-8. PMID 10913267 DOI: 10.1021/Bi000537P  0.582
1999 Czerwinski RM, Harris TK, Johnson WH, Legler PM, Stivers JT, Mildvan AS, Whitman CP. Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis. Biochemistry. 38: 12358-66. PMID 10493803 DOI: 10.1021/Bi9911177  0.638
1999 Harris TK, Czerwinski RM, Johnson WH, Legler PM, Abeygunawardana C, Massiah MA, Stivers JT, Whitman CP, Mildvan AS. Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase. Biochemistry. 38: 12343-57. PMID 10493802 DOI: 10.1021/Bi991116E  0.652
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