| Year |
Citation |
Score |
| 2023 |
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, ... ... Robbins DJ, et al. The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature Communications. 14: 6173. PMID 37798301 DOI: 10.1038/s41467-023-41836-z |
0.575 |
|
| 2023 |
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, ... Robbins DJ, et al. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nature Communications. 14: 6174. PMID 37798281 DOI: 10.1038/s41467-023-41843-0 |
0.364 |
|
| 2023 |
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, et al. USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling. Science Signaling. 16: eabn8372. PMID 36749823 DOI: 10.1126/scisignal.abn8372 |
0.727 |
|
| 2022 |
Yang F, Wynn DT, Shen C, Ayad NG, Robbins DJ. Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer. Life (Basel, Switzerland). 12. PMID 36556332 DOI: 10.3390/life12121967 |
0.4 |
|
| 2022 |
Wynn DT, Rodriguez-Blanco J, Long J, Yang F, Shen C, Fei D, Tang HY, Hanson D, Robbins DJ. Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression. Neuro-Oncology Advances. 4: vdac144. PMID 36299796 DOI: 10.1093/noajnl/vdac144 |
0.302 |
|
| 2022 |
Yang F, Rodriguez-Blanco J, Long J, Swiderska-Syn M, Wynn DT, Li B, Shen C, Nayak A, Ban Y, Sun X, Suter RK, McCrea HJ, Capobianco AJ, Ayad NG, Robbins DJ. A druggable UHRF1/DNMT1/GLI complex regulates Sonic hedgehog dependent tumor growth. Molecular Cancer Research : McR. PMID 35925047 DOI: 10.1158/1541-7786.MCR-22-0182 |
0.326 |
|
| 2022 |
Shen C, Nayak A, Neitzel LR, Yang F, Li B, Williams CH, Hong CC, Ahmed Y, Lee E, Robbins DJ. The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon. The Journal of Biological Chemistry. 102227. PMID 35780831 DOI: 10.1016/j.jbc.2022.102227 |
0.425 |
|
| 2021 |
Shersher E, Lahiry M, Alvarez-Trotta A, Diluvio G, Robbins DJ, Shiekhattar R, Capobianco AJ. NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis. Cell Communication and Signaling : Ccs. 19: 96. PMID 34551776 DOI: 10.1186/s12964-021-00776-1 |
0.321 |
|
| 2021 |
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, ... ... Robbins DJ, et al. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nature Communications. 12: 5263. PMID 34489457 DOI: 10.1038/s41467-021-25634-z |
0.458 |
|
| 2020 |
Alvarez-Trotta A, Wang Z, Shersher E, Li B, Long J, Lohse I, Wahlestedt C, El-Rifai W, Robbins DJ, Capobianco AJ. The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling. Oncotarget. 11: 3174-3187. PMID 32913560 DOI: 10.18632/Oncotarget.27699 |
0.321 |
|
| 2020 |
Shen C, Nayak A, Melendez RA, Wynn DT, Jackson J, Lee E, Ahmed Y, Robbins DJ. Casein Kinase 1α as a Regulator of Wnt-Driven Cancer. International Journal of Molecular Sciences. 21. PMID 32824859 DOI: 10.3390/Ijms21165940 |
0.455 |
|
| 2020 |
Anthony CC, Robbins DJ, Ahmed Y, Lee E. Nuclear Regulation of Wnt/β-Catenin Signaling: It's a Complex Situation. Genes. 11. PMID 32759724 DOI: 10.3390/Genes11080886 |
0.338 |
|
| 2019 |
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/Acs.Biochem.9B00891 |
0.604 |
|
| 2019 |
Cabel CR, Alizadeh E, Robbins DJ, Ahmed Y, Lee E, Thorne CA. Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells. Developmental Cell. 49: 827-828. PMID 31211991 DOI: 10.1016/J.Devcel.2019.05.039 |
0.711 |
|
| 2019 |
Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E. Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Mechanisms of Development. PMID 30904594 DOI: 10.1016/J.Mod.2019.03.002 |
0.436 |
|
| 2018 |
Robbins DJ, Rodriguez-Blanco J, Li B, Shen C, Orton D, Collins SA, Kasahara N, Ayad N, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Long J, Yang F. A CK1α activator penetrates the brain, and shows efficacy against drug-resistant metastatic medulloblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30487124 DOI: 10.1158/1078-0432.Ccr-18-1319 |
0.532 |
|
| 2018 |
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, et al. APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Developmental Cell. 44: 566-581.e8. PMID 29533772 DOI: 10.1016/J.Devcel.2018.02.013 |
0.345 |
|
| 2018 |
Rodriguez Blanco J, Li B, Long J, Orthon D, Ayad N, MaCrea H, Roussel M, Weiss W, Capobianco A, Robbins D. DDIS-11. A CK1a ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA Neuro-Oncology. 20: vi71-vi71. DOI: 10.1093/Neuonc/Noy148.290 |
0.379 |
|
| 2018 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss W, Rodriguez C, Mehrdad N, Nguyen D, Ayad N, Rai P, Capobianco A, Robbins D. MBRS-64. SURPRISING ROLE FOR WNT SIGNALING IN SONIC HEDGEHOG DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 20: i142-i142. DOI: 10.1093/Neuonc/Noy059.508 |
0.589 |
|
| 2017 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. PMID 28714964 DOI: 10.1038/Onc.2017.232 |
0.502 |
|
| 2017 |
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, ... Robbins DJ, et al. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Science Signaling. 10. PMID 28655862 DOI: 10.1126/Scisignal.Aak9916 |
0.771 |
|
| 2017 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss W, Rodriguez C, Merhdad N, Nguyen D, Ayad N, Rai P, Capobianco A, Robbins DJ. PDTM-03. SURPRISING ROLE FOR WNT SIGNALING IN Trp53-MUTANT SHH MEDULLOBLASTOMA Neuro-Oncology. 19: vi190-vi190. DOI: 10.1093/Neuonc/Nox168.768 |
0.572 |
|
| 2016 |
Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Reports. PMID 27210761 DOI: 10.1016/J.Celrep.2016.04.070 |
0.315 |
|
| 2016 |
Astudillo L, da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver KL, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, et al. The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesis. Cancer Research. PMID 27197169 DOI: 10.1158/0008-5472.Can-16-0061 |
0.304 |
|
| 2016 |
Abujarour R, Lan W, Lee TT, Bonello G, Meza M, Robinson M, Clarke R, Truong C, Lynn C, Robbins D, Rezner B, Abbot SE, Shoemaker D, Valamehr B. Efficient Site-Specific Multi-Gene Engineering of Renewable Pluripotent Cells for Generation of Off-the-Shelf Hematopoietic Immunotherapeutics Blood. 128: 5887-5887. DOI: 10.1182/Blood.V128.22.5887.5887 |
0.319 |
|
| 2016 |
Rosen J, Rezner B, Robbins D, Hardy I, Peralta E, Maine C, Sabouri M, Reynal S, Truong C, Moreno S, Foster H, Borchelt S, Meza M, Thompson L, Fontenot J, et al. Identification of Small Molecule Modulators to Enhance the Therapeutic Properties of Chimeric Antigen Receptor T Cells Blood. 128: 4712-4712. DOI: 10.1182/BLOOD.V128.22.4712.4712 |
0.316 |
|
| 2016 |
Clarke R, Groff B, Sasaki J, Bauer M, Lee TT, Lan W, Burrascano M, Abujarour R, Bonello G, Robinson M, Foster H, Robbins D, Wolchko S, Shoemaker D, Abbot SE, et al. Genetically Enhanced Pluripotent Stem Cell-Derived T Lymphocytes for Off-the-Shelf Cellular Immunotherapy Blood. 128: 2164-2164. DOI: 10.1182/Blood.V128.22.2164.2164 |
0.314 |
|
| 2016 |
Castellanos J, Srinivasan S, Honnenahally K, Shi C, VanSaun M, Robbins D, Merchant N, Nagathihalli N. Abstract 2618: Oncogenic mutant KRAS modulates CREB activation through MEK-ERK and AKT signaling in pancreatic cancer Cancer Research. 76: 2618-2618. DOI: 10.1158/1538-7445.Am2016-2618 |
0.383 |
|
| 2015 |
Li B, Giambelli C, Tang B, Winterbottom E, Long J, Jin K, Wang Z, Liang Fei D, Nguyen DM, Athar M, Wang B, Subbarayan PR, Wang L, Rai P, Ardalan B, ... Robbins DJ, et al. Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context Dependent Manner. Molecular Pharmacology. PMID 26573582 DOI: 10.1124/Mol.115.100867 |
0.413 |
|
| 2015 |
Farzan SF, Robbins DJ. Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components. Methods in Molecular Biology (Clifton, N.J.). 1322: 93-104. PMID 26179042 DOI: 10.1007/978-1-4939-2772-2_9 |
0.377 |
|
| 2015 |
Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, et al. Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell Reports. 11: 249-60. PMID 25843713 DOI: 10.1016/J.Celrep.2015.03.016 |
0.301 |
|
| 2015 |
Allen BK, Stathias V, Maloof ME, Vidovic D, Winterbottom EF, Capobianco AJ, Clarke J, Schurer S, Robbins DJ, Ayad NG. Epigenetic pathways and glioblastoma treatment: insights from signaling cascades. Journal of Cellular Biochemistry. 116: 351-63. PMID 25290986 DOI: 10.1002/Jcb.24990 |
0.309 |
|
| 2015 |
Huang X, Lan W, Parone P, Clarke R, Abujarour R, Robinson M, Meza M, Raynel S, Rezner B, Robbins D, Lee TT, Shoemaker D, Valamehr B. Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics Blood. 126: 3237-3237. DOI: 10.1182/Blood.V126.23.3237.3237 |
0.334 |
|
| 2015 |
Clarke R, Kim W, Groff B, Abujarour R, Robinson M, Huang X, Sahaf N, Raynel S, Rezner B, Robbins D, Guerrettaz L, Shoemaker D, Valamehr B. A Platform for the Scalable Derivation of Genetically-Enhanced T and NK Lymphocytes from Naive Human Induced Pluripotent Stem Cells for Cancer Immunotherapy Blood. 126: 2364-2364. DOI: 10.1182/Blood.V126.23.2364.2364 |
0.311 |
|
| 2015 |
Allen BK, Stathias V, Maloof ME, Vidovic D, Winterbottom EF, Capobianco AJ, Clarke J, Schurer S, Robbins DJ, Ayad NG. Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades Journal of Cellular Biochemistry. 116: iii. DOI: 10.1002/Jcb.25034 |
0.328 |
|
| 2014 |
Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. The Journal of Biological Chemistry. 289: 35494-502. PMID 25355313 DOI: 10.1074/Jbc.M114.595348 |
0.438 |
|
| 2014 |
Wang Z, Da Silva TG, Jin K, Han X, Ranganathan P, Zhu X, Sanchez-Mejias A, Bai F, Li B, Fei DL, Weaver K, Carpio RV, Moscowitz AE, Koshenkov VP, Sanchez L, ... Robbins DJ, et al. Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma. Cancer Research. 74: 6364-74. PMID 25164006 DOI: 10.1158/0008-5472.Can-14-2051 |
0.303 |
|
| 2014 |
Weaver KL, Alves-Guerra MC, Jin K, Wang Z, Han X, Ranganathan P, Zhu X, DaSilva T, Liu W, Ratti F, Demarest RM, Tzimas C, Rice M, Vasquez-Del Carpio R, Dahmane N, Robbins DJ, et al. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer Research. 74: 4741-51. PMID 25038227 DOI: 10.1158/0008-5472.Can-14-1547 |
0.349 |
|
| 2014 |
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ, et al. Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer Research. 74: 4811-21. PMID 24994715 DOI: 10.1158/0008-5472.Can-14-0317 |
0.443 |
|
| 2014 |
Abujarour R, Bennett M, Valamehr B, Lee TT, Robinson M, Robbins D, Le T, Lai K, Flynn P. Myogenic differentiation of muscular dystrophy-specific induced pluripotent stem cells for use in drug discovery. Stem Cells Translational Medicine. 3: 149-60. PMID 24396035 DOI: 10.5966/Sctm.2013-0095 |
0.306 |
|
| 2014 |
You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro. The Journal of Thoracic and Cardiovascular Surgery. 147: 508-16. PMID 24094913 DOI: 10.1016/J.Jtcvs.2013.08.035 |
0.341 |
|
| 2014 |
Robbins D. An introduction to EMG Signal processing using MatLab and Microsoft Excel Applications, Challenges, and Advancements in Electromyography Signal Processing. 95-112. DOI: 10.4018/978-1-4666-6090-8.ch004 |
0.302 |
|
| 2014 |
Robbins D, Le T, Troung C, Foster H, Rezner B, Mitchell L, Guerrettaz L, Multani PS, Shoemaker D. Ex Vivo Modulation of Mobilized Peripheral Blood: Characterization of HSC and T-Cell Responses to Prostaglandin E2 Blood. 124: 1092-1092. DOI: 10.1182/BLOOD.V124.21.1092.1092 |
0.308 |
|
| 2014 |
Singh S, Nguyen DM, Capobianco AJ, Robbins DJ. Abstract 1951: Role of embryonic signaling pathways in lung cancer Cancer Research. 74: 1951-1951. DOI: 10.1158/1538-7445.Am2014-1951 |
0.335 |
|
| 2013 |
Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, ... Robbins DJ, et al. The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene. 32: 2335-45. PMID 22733134 DOI: 10.1038/Onc.2012.243 |
0.316 |
|
| 2013 |
You M, Santos JV, Robbins DJ, Savaraj N, Nguyen DM. Abstract 3246: Pharmacologic targeting of the Hedgehog (HH) signal transduction pathway significantly suppresses growth of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) cells in vitro. Cancer Research. 73: 3246-3246. DOI: 10.1158/1538-7445.Am2013-3246 |
0.377 |
|
| 2013 |
Singh S, Robbins D, Capobianco AJ, Nguyen DM. Abstract 2645: Role of embryonic signaling pathways in lung cancer. Cancer Research. 73: 2645-2645. DOI: 10.1158/1538-7445.Am2013-2645 |
0.336 |
|
| 2012 |
Robbins DJ, Fei DL, Riobo NA. The Hedgehog signal transduction network. Science Signaling. 5: re6. PMID 23074268 DOI: 10.1126/Scisignal.2002906 |
0.441 |
|
| 2012 |
Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, ... Robbins DJ, et al. Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Research. 72: 4449-58. PMID 22815529 DOI: 10.1158/0008-5472.Can-11-4123 |
0.314 |
|
| 2012 |
Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & Medicinal Chemistry. 20: 1869-77. PMID 22261025 DOI: 10.1016/J.Bmc.2011.12.044 |
0.686 |
|
| 2012 |
Wang Z, Ranganathan P, Koshenkov V, Bai F, Li B, Fei DL, Livingstone A, Franceschi D, Martell J, Robbins DJ, Capobianco AJ. Abstract 3336: The role of Notch signaling in esophageal adenocarcinoma Cancer Research. 72: 3336-3336. DOI: 10.1158/1538-7445.Am2012-3336 |
0.414 |
|
| 2011 |
Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, ... Robbins DJ, et al. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. Journal of Biomolecular Screening. 16: 995-1006. PMID 21859680 DOI: 10.1177/1087057111416657 |
0.723 |
|
| 2011 |
Singh S, Wang Z, Giambelli C, Long J, Briegel KJ, Bejarano PA, Capobianco AJ, Robbins DJ. Abstract LB-430: Hedgehog signaling is required for the survival and tumorigenicity of cancer cells. Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-430 |
0.324 |
|
| 2011 |
Galimberti F, Busch A, Chinyengetere F, Ma T, Sekula D, Memoli V, Dragnev K, Liu F, Andrew AS, Greninger P, Robbins D, Settleman J, Benes C, Dmitrovsky E. Abstract 1615: Gene expression profile predicts response to smoothened inhibitors in epithelial cancers Cancer Research. 71: 1615-1615. DOI: 10.1158/1538-7445.Am2011-1615 |
0.38 |
|
| 2010 |
Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y. Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G1252-65. PMID 20847300 DOI: 10.1152/Ajpgi.00512.2009 |
0.301 |
|
| 2010 |
Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ. Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Research. 70: 1981-8. PMID 20179202 DOI: 10.1158/0008-5472.Can-09-2898 |
0.318 |
|
| 2010 |
Farzan SF, Ogden SK, Robbins DJ. Quantitative insight into models of Hedgehog signal transduction Fly. 4: 141-144. PMID 20081354 DOI: 10.4161/Fly.4.2.10927 |
0.448 |
|
| 2010 |
Tokhunts R, Singh S, Chu T, D'Angelo G, Baubet V, Goetz JA, Huang Z, Yuan Z, Ascano M, Zavros Y, Thérond PP, Kunes S, Dahmane N, Robbins DJ. The full-length unprocessed hedgehog protein is an active signaling molecule. The Journal of Biological Chemistry. 285: 2562-8. PMID 19920144 DOI: 10.1074/Jbc.M109.078626 |
0.738 |
|
| 2009 |
Farzan SF, Stegman MA, Ogden SK, Ascano M, Black KE, Tacchelly O, Robbins DJ. A quantification of pathway components supports a novel model of Hedgehog signal transduction. The Journal of Biological Chemistry. 284: 28874-84. PMID 19717563 DOI: 10.1074/Jbc.M109.041608 |
0.808 |
|
| 2008 |
Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature. 456: 967-70. PMID 18987629 DOI: 10.1038/Nature07459 |
0.478 |
|
| 2008 |
Farzan SF, Ascano M, Ogden SK, Sanial M, Brigui A, Plessis A, Robbins DJ. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Current Biology : Cb. 18: 1215-20. PMID 18691888 DOI: 10.1016/J.Cub.2008.07.026 |
0.751 |
|
| 2008 |
Li N, Singh S, Cherukuri P, Li H, Yuan Z, Ellisen LW, Wang B, Robbins D, DiRenzo J. Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (Dayton, Ohio). 26: 1253-64. PMID 18292212 DOI: 10.1634/Stemcells.2007-0691 |
0.311 |
|
| 2008 |
Farzan SF, Singh S, Schilling NS, Robbins DJ. The adventures of sonic hedgehog in development and repair. III. Hedgehog processing and biological activity. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G844-9. PMID 18239057 DOI: 10.1152/ajpgi.00564.2007 |
0.328 |
|
| 2007 |
Stegman M, Robbins D. Biochemical fractionation of Drosophila cells. Methods in Molecular Biology (Clifton, N.J.). 397: 203-13. PMID 18025722 DOI: 10.1007/978-1-59745-516-9_14 |
0.661 |
|
| 2007 |
Robbins DJ, Hebrok M. Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells. Embo Reports. 8: 451-5. PMID 17431408 DOI: 10.1038/Sj.Embor.7400959 |
0.326 |
|
| 2006 |
Ogden SK, Casso DJ, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. The Journal of Biological Chemistry. 281: 7237-43. PMID 16423832 DOI: 10.1074/Jbc.M510169200 |
0.768 |
|
| 2005 |
Robbins D, Goetz J, Yuan Z, Stegman M. Inhibitors of the Hedgehog Signal Transduction Pathway Current Cancer Therapy Reviews. 1: 277-288. DOI: 10.2174/157339405774574243 |
0.718 |
|
| 2004 |
Ascano M, Robbins DJ. An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Molecular and Cellular Biology. 24: 10397-405. PMID 15542847 DOI: 10.1128/Mcb.24.23.10397-10405.2004 |
0.761 |
|
| 2004 |
Ogden SK, Ascano M, Stegman MA, Robbins DJ. Regulation of Hedgehog signaling: a complex story. Biochemical Pharmacology. 67: 805-14. PMID 15104233 DOI: 10.1016/J.Bcp.2004.01.002 |
0.805 |
|
| 2004 |
Stegman MA, Goetz JA, Ascano M, Ogden SK, Nybakken KE, Robbins DJ. The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. The Journal of Biological Chemistry. 279: 7064-71. PMID 14645371 DOI: 10.1074/Jbc.M311794200 |
0.783 |
|
| 2003 |
Ogden SK, Ascano M, Stegman MA, Suber LM, Hooper JE, Robbins DJ. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Current Biology : Cb. 13: 1998-2003. PMID 14614827 DOI: 10.1016/J.Cub.2003.10.004 |
0.819 |
|
| 2002 |
Nybakken KE, Turck CW, Robbins DJ, Bishop JM. Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. The Journal of Biological Chemistry. 277: 24638-47. PMID 11934882 DOI: 10.1074/jbc.M110730200 |
0.566 |
|
| 2002 |
Alvarez J, Sohn P, Zeng X, Doetschman T, Robbins DJ, Serra R. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development (Cambridge, England). 129: 1913-24. PMID 11934857 |
0.338 |
|
| 2002 |
Ascano M, Nybakken KE, Sosinski J, Stegman MA, Robbins DJ. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Molecular and Cellular Biology. 22: 1555-66. PMID 11839821 DOI: 10.1128/Mcb.22.5.1555-1566.2002 |
0.8 |
|
| 2002 |
Goetz JA, Suber LM, Zeng X, Robbins DJ. Sonic Hedgehog as a mediator of long-range signaling. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 157-65. PMID 11835280 DOI: 10.1002/bies.10056 |
0.337 |
|
| 2001 |
Zeng X, Goetz JA, Suber LM, Scott WJ, Schreiner CM, Robbins DJ. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature. 411: 716-20. PMID 11395778 DOI: 10.1038/35079648 |
0.302 |
|
| 2000 |
Stegman MA, Vallance JE, Elangovan G, Sosinski J, Cheng Y, Robbins DJ. Identification of a tetrameric hedgehog signaling complex. The Journal of Biological Chemistry. 275: 21809-12. PMID 10825151 DOI: 10.1074/jbc.C000043200 |
0.69 |
|
| 1997 |
Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Thérond PP. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell. 90: 225-34. PMID 9244297 DOI: 10.1016/S0092-8674(00)80331-1 |
0.58 |
|
| 1996 |
Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Advances in Pharmacology (San Diego, Calif.). 36: 49-65. PMID 8783554 DOI: 10.1016/S1054-3589(08)60576-1 |
0.558 |
|
| 1996 |
Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt CA, Cobb MH. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 5291-5. PMID 8643568 DOI: 10.1073/pnas.93.11.5291 |
0.508 |
|
| 1995 |
Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6808-12. PMID 7624324 DOI: 10.1073/pnas.92.15.6808 |
0.607 |
|
| 1995 |
Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098 DOI: 10.1073/Pnas.92.13.6180 |
0.665 |
|
| 1994 |
Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-11. PMID 8107865 DOI: 10.1038/367704A0 |
0.582 |
|
| 1994 |
Robbins DJ, Zhen E, Cheng M, Xu S, Ebert D, Cobb MH. MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Advances in Cancer Research. 63: 93-116. PMID 8036991 |
0.528 |
|
| 1994 |
Cobb MH, Xu S, Hepler JE, Hutchison M, Frost J, Robbins DJ. Regulation of the MAP kinase cascade. Cellular & Molecular Biology Research. 40: 253-6. PMID 7874203 |
0.566 |
|
| 1994 |
Cobb MH, Hepler JE, Cheng M, Robbins D. The mitogen-activated protein kinases, ERK1 and ERK2. Seminars in Cancer Biology. 5: 261-8. PMID 7803762 |
0.581 |
|
| 1993 |
Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. The Journal of Biological Chemistry. 268: 5097-106. PMID 8444886 |
0.566 |
|
| 1993 |
Zhang F, Robbins DJ, Cobb MH, Goldsmith EJ. Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag. Journal of Molecular Biology. 233: 550-2. PMID 8411162 DOI: 10.1006/Jmbi.1993.1532 |
0.579 |
|
| 1993 |
Robbins DJ, Zhen E, Cheng M, Xu S, Vanderbilt CA, Ebert D, Garcia C, Dang A, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3. Journal of the American Society of Nephrology : Jasn. 4: 1104-10. PMID 8305637 |
0.608 |
|
| 1993 |
Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell. 75: 887-97. PMID 8252625 DOI: 10.1016/0092-8674(93)90533-V |
0.596 |
|
| 1992 |
Robbins DJ, Cobb MH. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping. Molecular Biology of the Cell. 3: 299-308. PMID 1627831 |
0.534 |
|
| 1992 |
Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA, Cobb MH. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proceedings of the National Academy of Sciences of the United States of America. 89: 6924-8. PMID 1495981 DOI: 10.1073/Pnas.89.15.6924 |
0.531 |
|
| 1992 |
Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464 DOI: 10.1111/J.1471-4159.1992.Tb08885.X |
0.558 |
|
| 1991 |
Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J |
0.567 |
|
| 1991 |
Cobb MH, Boulton TG, Robbins DJ. Extracellular signal-regulated kinases: ERKs in progress. Cell Regulation. 2: 965-78. PMID 1801927 |
0.604 |
|
| 1991 |
Cobb MH, Robbins DJ, Boulton TG. ERKs, extracellular signal-regulated MAP-2 kinases. Current Opinion in Cell Biology. 3: 1025-32. PMID 1667578 DOI: 10.1016/0955-0674(91)90124-H |
0.588 |
|
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