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James L. Hougland, Ph.D. - Publications

Affiliations: 
2005-2010 Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
 2010- Chemistry Syracuse University, Syracuse, NY, United States 
Area:
chemistry and biochemistryof nucleic acids
Website:
https://hougland.expressions.syr.edu/
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Justyna K, Das R, Lorimer EL, Hu J, Pedersen JS, Sprague-Getsy AM, Schey GL, Sieburg MA, Koehn OJ, Wang YC, Chen YX, Hougland JL, Williams CL, Distefano MD. Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues. Organic Letters. PMID 37669435 DOI: 10.1021/acs.orglett.3c02736  0.388
2023 Campaña MB, Davis TR, Novak SX, Cleverdon ER, Bates M, Krishnan N, Curtis ER, Childs MD, Pierce MR, Morales-Rodriguez Y, Sieburg MA, Hehnly H, Luyt LG, Hougland JL. Cellular Uptake of a Fluorescent Ligand Reveals Ghrelin -Acyltransferase Interacts with Extracellular Peptides and Exhibits Unexpected Localization for a Secretory Pathway Enzyme. Acs Chemical Biology. PMID 37494676 DOI: 10.1021/acschembio.3c00334  0.792
2023 Pierce MR, Hougland JL. A rising tide lifts all MBOATs: recent progress in structural and functional understanding of membrane bound -acyltransferases. Frontiers in Physiology. 14: 1167873. PMID 37250116 DOI: 10.3389/fphys.2023.1167873  0.332
2022 Morstein J, Bader T, Cardillo AL, Schackmann J, Ashok S, Hougland JL, Hrycyna CA, Trauner DH, Distefano MD. Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. Acs Chemical Biology. PMID 36194691 DOI: 10.1021/acschembio.2c00645  0.773
2022 Hossain MS, Zhang Z, Ashok S, Jenks AR, Lynch CJ, Hougland JL, Mozhdehi D. Temperature-Responsive Nano-Biomaterials from Genetically Encoded Farnesylated Disordered Proteins. Acs Applied Bio Materials. PMID 35044146 DOI: 10.1021/acsabm.1c01162  0.787
2021 Schey GL, Buttery PH, Hildebrandt ER, Novak SX, Schmidt WK, Hougland JL, Distefano MD. MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase. International Journal of Molecular Sciences. 22. PMID 34769472 DOI: 10.3390/ijms222112042  0.362
2021 Davis TR, Pierce MR, Novak SX, Hougland JL. Ghrelin octanoylation by ghrelin -acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling. Open Biology. 11: 210080. PMID 34315274 DOI: 10.1098/rsob.210080  0.356
2020 Wang Y, Kilic O, Csizmar CM, Ashok S, Hougland JL, Distefano MD, Wagner CR. Engineering reversible cell-cell interactions using enzymatically lipidated chemically self-assembled nanorings. Chemical Science. 12: 331-340. PMID 34168743 DOI: 10.1039/d0sc03194a  0.774
2020 Moose JE, Leets KA, Mate NA, Chisholm JD, Hougland JL. An overview of ghrelin -acyltransferase inhibitors: a literature and patent review for 2010-2019. Expert Opinion On Therapeutic Patents. 1-13. PMID 32564644 DOI: 10.1080/13543776.2020.1776263  0.381
2020 Ashok S, Hildebrandt ER, Ruiz CS, Hardgrove DS, Coreno DW, Schmidt WK, Hougland JL. Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences. Biochemistry. PMID 32125828 DOI: 10.1021/Acs.Biochem.0C00081  0.8
2019 Abizaid A, Hougland JL. Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity. Trends in Endocrinology and Metabolism: Tem. PMID 31636018 DOI: 10.1016/J.Tem.2019.09.006  0.347
2019 Campaña MB, Irudayanathan FJ, Davis TR, McGovern-Gooch KR, Loftus R, Ashkar M, Escoffery N, Navarro M, Sieburg MA, Nangia S, Hougland JL. The ghrelin -acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation. The Journal of Biological Chemistry. PMID 31413115 DOI: 10.1074/Jbc.Ac119.009749  0.778
2019 Sieburg MA, Cleverdon ER, Hougland JL. Biochemical Assays for Ghrelin Acylation and Inhibition of Ghrelin O-Acyltransferase. Methods in Molecular Biology (Clifton, N.J.). 2009: 227-241. PMID 31152408 DOI: 10.1007/978-1-4939-9532-5_18  0.816
2019 Hougland JL. Ghrelin octanoylation by ghrelin -acyltransferase: Unique protein biochemistry underlying metabolic signaling. Biochemical Society Transactions. PMID 30626708 DOI: 10.1042/Bst20180436  0.501
2018 Berger BM, Kim JH, Hildebrandt ER, Davis IC, Morgan MC, Hougland JL, Schmidt WK. Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus. Genetics. PMID 30257935 DOI: 10.1534/Genetics.118.301454  0.404
2018 Cleverdon ER, Davis TR, Hougland JL. Functional group and stereochemical requirements for substrate binding by ghrelin O-acyltransferase revealed by unnatural amino acid incorporation. Bioorganic Chemistry. 79: 98-106. PMID 29738973 DOI: 10.1016/J.Bioorg.2018.04.009  0.82
2017 Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL. Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome. The Journal of Biological Chemistry. PMID 29282289 DOI: 10.1074/Jbc.M117.805770  0.8
2017 Shala-Lawrence A, Blanden MJ, Krylova SM, Gangopadhyay SA, Beloborodov SS, Hougland JL, Krylov SN. Simultaneous Analysis of a Non-Lipidated Protein and Its Lipidated Counterpart: Enabling Quantitative Investigation of Protein Lipidation's Impact on Cellular Regulation. Analytical Chemistry. PMID 29144728 DOI: 10.1021/Acs.Analchem.7B03846  0.778
2017 Cleverdon ER, McGovern-Gooch KR, Hougland JL. The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin's biological interactions and avenues for controlling ghrelin signaling. Molecular Membrane Biology. 1-14. PMID 29143554 DOI: 10.1080/09687688.2017.1388930  0.771
2017 McGovern-Gooch KR, Mahajani NS, Garagozzo A, Schramm AJ, Hannah LG, Sieburg MA, Chisholm JD, Hougland JL. Synthetic triterpenoid inhibition of human ghrelin O-acyltransferase: Involvement of a functionally required cysteine provides mechanistic insight into ghrelin acylation. Biochemistry. PMID 28134508 DOI: 10.1021/Acs.Biochem.6B01008  0.799
2016 McGovern-Gooch KR, Rodrigues T, Darling JE, Sieburg MA, Abizaid A, Hougland JL. Ghrelin octanoylation is completely stabilized in biological samples by alkyl fluorophosphonates. Endocrinology. en20161657. PMID 27623288 DOI: 10.1210/En.2016-1657  0.783
2015 Zhang Y, Blanden MJ, Chava S, Gangopadhyay SA, Rashidian M, Hougland JL, Distefano MD. Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases. Bioconjugate Chemistry. PMID 26561785 DOI: 10.1021/Acs.Bioconjchem.5B00553  0.791
2015 Wellman MK, Patterson ZR, MacKay H, Darling JE, Mani BK, Zigman JM, Hougland JL, Abizaid A. Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice. Frontiers in Endocrinology. 6: 144. PMID 26441834 DOI: 10.3389/Fendo.2015.00144  0.777
2015 McGovern KR, Darling JE, Hougland JL. Progress in Small Molecule and Biologic Therapeutics Targeting Ghrelin Signaling. Mini Reviews in Medicinal Chemistry. PMID 26202202 DOI: 10.2174/1389557515666150722101329  0.798
2015 Zhao F, Darling JE, Gibbs RA, Hougland JL. A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups. Bioorganic & Medicinal Chemistry Letters. 25: 2800-3. PMID 26009163 DOI: 10.1016/J.Bmcl.2015.05.009  0.779
2015 Darling JE, Zhao F, Loftus RJ, Patton LM, Gibbs RA, Hougland JL. Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. Biochemistry. 54: 1100-10. PMID 25562443 DOI: 10.1021/Bi5010359  0.831
2014 Flynn SC, Lindgren DE, Hougland JL. Quantitative determination of cellular farnesyltransferase activity: towards defining the minimum substrate reactivity for biologically relevant protein farnesylation. Chembiochem : a European Journal of Chemical Biology. 15: 2205-10. PMID 25182009 DOI: 10.1002/Cbic.201402239  0.823
2014 Gangopadhyay SA, Losito EL, Hougland JL. Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition. Biochemistry. 53: 434-46. PMID 24344934 DOI: 10.1021/Bi4011732  0.706
2013 Darling JE, Prybolsky EP, Sieburg M, Hougland JL. A fluorescent peptide substrate facilitates investigation of ghrelin recognition and acylation by ghrelin O-acyltransferase. Analytical Biochemistry. 437: 68-76. PMID 23453974 DOI: 10.1016/J.Ab.2013.02.013  0.831
2012 Hougland JL, Gangopadhyay SA, Fierke CA. Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. The Journal of Biological Chemistry. 287: 38090-100. PMID 22992747 DOI: 10.1074/Jbc.M112.404954  0.779
2012 Placzek AT, Hougland JL, Gibbs RA. Synthesis of frame-shifted farnesyl diphosphate analogs. Organic Letters. 14: 4038-41. PMID 22857735 DOI: 10.1021/Ol300683R  0.31
2011 London N, Lamphear CL, Hougland JL, Fierke CA, Schueler-Furman O. Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. Plos Computational Biology. 7: e1002170. PMID 21998565 DOI: 10.1371/Journal.Pcbi.1002170  0.801
2011 Lamphear CL, Zverina EA, Hougland JL, Fierke CA. Global Identification of Protein Prenyltransferase Substrates. Defining the Prenylated Proteome. Enzymes. 29: 207-234. DOI: 10.1016/B978-0-12-381339-8.00012-3  0.812
2010 Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates. Bioorganic & Medicinal Chemistry Letters. 20: 767-70. PMID 20005705 DOI: 10.1016/J.Bmcl.2009.11.011  0.651
2010 Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. Journal of Molecular Biology. 395: 176-90. PMID 19878682 DOI: 10.1016/J.Jmb.2009.10.038  0.827
2009 Hougland JL, Piccirilli JA. 2'-amino-modified ribonucleotides as probes for local interactions within RNA. Methods in Enzymology. 468: 107-25. PMID 20946767 DOI: 10.1016/S0076-6879(09)68006-X  0.544
2009 Hougland JL, Fierke CA. Getting a handle on protein prenylation. Nature Chemical Biology. 5: 197-8. PMID 19295521 DOI: 10.1038/Nchembio0409-197  0.606
2009 Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA. Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry. 48: 1691-701. PMID 19199818 DOI: 10.1021/Bi801710G  0.812
2008 Hougland JL, Sengupta RN, Dai Q, Deb SK, Piccirilli JA. The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction. Biochemistry. 47: 7684-94. PMID 18572927 DOI: 10.1021/Bi8000648  0.671
2006 Dai Q, Deb SK, Hougland JL, Piccirilli JA. Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite. Bioorganic & Medicinal Chemistry. 14: 705-13. PMID 16202607 DOI: 10.1016/J.Bmc.2005.08.050  0.685
2006 Hougland JL, Piccirilli JA, Forconi M, Lee J, Herschlag D. 6 How the Group I Intron Works: A Case Study of RNA Structure and Function Cold Spring Harbor Monograph Archive. 43: 133-205. DOI: 10.1101/087969739.43.133  0.52
2005 Hougland JL, Kravchuk AV, Herschlag D, Piccirilli JA. Functional identification of catalytic metal ion binding sites within RNA. Plos Biology. 3: e277. PMID 16092891 DOI: 10.1371/Journal.Pbio.0030277  0.558
2004 Hougland JL, Deb SK, Maric D, Piccirilli JA. An atomic mutation cycle for exploring RNA's 2'-hydroxyl group. Journal of the American Chemical Society. 126: 13578-9. PMID 15493890 DOI: 10.1021/Ja0469129  0.657
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