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Kevin P. Cole, Ph.D. - Publications

Affiliations: 
2005 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Natural Product Synthesis
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Day JI, Allen-Moyer KN, Cole KP. Process Development for a 1-Indazole Synthesis Using an Intramolecular Ullmann-Type Reaction. The Journal of Organic Chemistry. 88: 4209-4223. PMID 36951763 DOI: 10.1021/acs.joc.2c02771  0.337
2020 Cole KP, Argentine MD, Conder EW, Vaid RK, Feng P, Jia M, Huang P, Liu P, Sun B, Tadayon S, Zhu C, Zhu R. Development and Production of an Enantioselective Tetrahydroisoquinoline Synthesis Enabled by Continuous Cryogenic Lithium–Halogen Exchange Organic Process Research & Development. DOI: 10.1021/Acs.Oprd.0C00141  0.337
2018 Alpers D, Cole K, Stephenson C. Visible light mediated aryl migration by homolytic C-N cleavage of aryl amines. Angewandte Chemie (International Ed. in English). PMID 30025192 DOI: 10.1002/Anie.201806659  0.355
2018 Lu Y, Cole KP, Fennell JW, Maloney TD, Mitchell D, Subbiah R, Ramadas B. An Alternative Indazole Synthesis for Merestinib Organic Process Research & Development. 22: 409-419. DOI: 10.1021/Acs.Oprd.8B00016  0.456
2017 Cole KP, Ryan SJ, Groh JM, Miller RD. Reagent-free continuous thermal tert-butyl ester deprotection. Bioorganic & Medicinal Chemistry. PMID 28336406 DOI: 10.1016/J.Bmc.2017.03.020  0.4
2016 Beatty JW, Douglas JJ, Miller R, McAtee RC, Cole KP, Stephenson CRJ. Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale. Chem. 1: 456-472. PMID 28462396 DOI: 10.1016/J.Chempr.2016.08.002  0.326
2016 Mitchell D, Kallman N, Cole K, Koenig T, Buser J, McFarland A, McNulty L. Synthesis of Aminopyrazoles from Isoxazoles: Comparison of Preparative Methods by in situ NMR Analysis Synthesis. 48: 3537-3543. DOI: 10.1055/S-0035-1561861  0.428
2016 Kopach ME, Cole KP, Pollock PM, Johnson MD, Braden TM, Webster LP, McClary Groh J, McFarland AD, Schafer JP, Adler JJ, Rosemeyer M. Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material Organic Process Research and Development. 20: 1581-1592. DOI: 10.1021/Acs.Oprd.6B00131  0.31
2016 Douglas JJ, Sevrin MJ, Cole KP, Stephenson CRJ. Preparative Scale Demonstration and Mechanistic Investigation of a Visible Light-Mediated Radical Smiles Rearrangement Organic Process Research and Development. 20: 1148-1155. DOI: 10.1021/Acs.Oprd.6B00126  0.31
2016 Cole KP, Campbell BM, Forst MB, McClary Groh J, Hess M, Johnson MD, Miller RD, Mitchell D, Polster CS, Reizman BJ, Rosemeyer M. An Automated Intermittent Flow Approach to Continuous Suzuki Coupling Organic Process Research and Development. 20: 820-830. DOI: 10.1021/Acs.Oprd.6B00030  0.302
2015 Devery Iii JJ, Douglas JJ, Nguyen JD, Cole KP, Flowers Ii RA, Stephenson CRJ. Ligand functionalization as a deactivation pathway in a fac-Ir(ppy)3-mediated radical addition. Chemical Science. 6: 537-541. PMID 28706624 DOI: 10.1039/C4Sc03064H  0.348
2015 Beatty JW, Douglas JJ, Cole KP, Stephenson CR. A scalable and operationally simple radical trifluoromethylation. Nature Communications. 6: 7919. PMID 26258541 DOI: 10.1038/Ncomms8919  0.367
2014 Douglas JJ, Cole KP, Stephenson CR. Photoredox catalysis in a complex pharmaceutical setting: toward the preparation of JAK2 inhibitor LY2784544. The Journal of Organic Chemistry. 79: 11631-43. PMID 25356724 DOI: 10.1021/Jo502288Q  0.335
2014 White TD, Alt CA, Cole KP, Groh JM, Johnson MD, Miller RD. How to convert a walk-in hood into a manufacturing facility: Demonstration of a continuous, high-temperature cyclization to process solids in flow Organic Process Research and Development. 18: 1482-1491. DOI: 10.1021/Op500239F  0.346
2014 Pollock PM, Cole KP. t‐Butyl as a Pyrazole Protecting Group: Preparation and Use of 1‐tert‐Butyl‐3‐Methyl‐1H‐Pyrazole‐5‐Amine Organic Syntheses. 537-548. DOI: 10.1002/0471264229.Os089.52  0.332
2013 Campbell AN, Cole KP, Martinelli JR, May SA, Mitchell D, Pollock PM, Sullivan KA. Development of an alternate synthesis for a key JAK2 inhibitor intermediate via sequential c-h bond functionalization Organic Process Research and Development. 17: 273-281. DOI: 10.1021/Op300344M  0.492
2013 Tang Y, Cole KP, Hsung RP. Phomactin A Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry. 183-210. DOI: 10.1007/978-3-642-34065-9_8  0.455
2012 Mitchell D, Cole KP, Pollock PM, Coppert DM, Burkholder TP, Clayton JR. Development and a practical synthesis of the JAK2 inhibitor LY2784544 Organic Process Research and Development. 16: 70-81. DOI: 10.1021/Op200229J  0.509
2011 Buchanan GS, Cole KP, Li G, Tang Y, You LF, Hsung RP. Constructing the Architecturally Distinctive ABD-Tricycle of Phomactin A through an Intramolecular Oxa-[3 + 3] Annulation Strategy. Tetrahedron. 67: 10105-10118. PMID 23750054 DOI: 10.1016/J.Tet.2011.09.111  0.787
2011 Buchanan GS, Cole KP, Tang Y, Hsung RP. Total synthesis of (±)-phomactin A. Lessons learned from respecting a challenging structural topology. The Journal of Organic Chemistry. 76: 7027-39. PMID 21819039 DOI: 10.1021/Jo200936R  0.719
2010 Wang J, Cole KP, Wei L, Zehnder LR, Hsung RP. ChemInform Abstract: An Unexpected Retro-Aldol-Aldol in the AB-Ring in the Synthesis of (.+-.)-Arisugacin A. Cheminform. 33: no-no. DOI: 10.1002/chin.200234211  0.772
2010 Zehnder LR, Wei L, Hsung RP, Cole KP, McLaughlin MJ, Shen HC, Sklenicka HM, Wang J, Zificsak CA. ChemInform Abstract: Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β-Unsaturated Iminium Ions with 1,3-Dicarbonyl Equivalents. Cheminform. 32: no-no. DOI: 10.1002/chin.200143065  0.742
2009 Tang Y, Cole KP, Buchanan GS, Li G, Hsung RP. Total synthesis of phomactin A. Organic Letters. 11: 1591-4. PMID 19260663 DOI: 10.1021/Ol900237E  0.727
2009 Cole KP, Mitchell D, Austin Carr M, Stout JR, Belvo MD. Synthesis and axial chirality of an enantiopure aminodibenzazepinone Tetrahedron Asymmetry. 20: 1262-1266. DOI: 10.1016/J.Tetasy.2009.04.016  0.465
2009 Tang Y, Cole KP, Buchanan GS, Li G, Hsung RP. ChemInform Abstract: Total Synthesis of Phomactin A (I). Cheminform. 40. DOI: 10.1002/chin.200934204  0.653
2008 You LF, Hsung RP, Bedermann AA, Kurdyumov AV, Tang Y, Buchanan GS, Cole KP. An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition. Advanced Synthesis & Catalysis. 350. PMID 24273477 DOI: 10.1002/Adsc.200800552  0.807
2008 You LF, Hsung RP, Bedermann AA, Kurdyumov AV, Tang Y, Buchanan GS, Cole KP. An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition. Advanced Synthesis & Catalysis. 350: 2885-2891. PMID 20351791  0.81
2007 Nicolaou KC, Cole KP, Frederick MO, Aversa RJ, Denton RM. Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin. Angewandte Chemie (International Ed. in English). 46: 8875-9. PMID 17943950 DOI: 10.1002/Anie.200703742  0.302
2006 Nicolaou KC, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV, Yamada YM. Second-generation total synthesis of azaspiracids-1, -2, and -3. Chemistry, An Asian Journal. 1: 245-63. PMID 17441061 DOI: 10.1002/Asia.200600059  0.416
2006 Kurdyumov AV, Lin N, Hsung RP, Gullickson GC, Cole KP, Sydorenko N, Swidorski JJ. A Lewis acid-catalyzed formal [3 + 3] cycloaddition of alpha,beta-unsaturated aldehydes with 4-hydroxy-2-pyrone, diketones, and vinylogous esters. Organic Letters. 8: 191-3. PMID 16408872 DOI: 10.1021/Ol0523042  0.786
2006 Kurdyumov AV, Lin N, Hsung RP, Gullickson GC, Cole KP, Sydorenko N, Swidorski JJ. A Lewis Acid Catalyzed Formal [3 + 3] Cycloaddition of α,β-Unsaturated Aldehydes with 4-Hydroxy-2-pyrone, Diketones, and Vinylogous Esters. Cheminform. 37. DOI: 10.1002/chin.200621141  0.738
2005 Cole KP, Hsung RP. Unique structural topology and reactivities of the ABD tricycle in phomactin A. Chemical Communications (Cambridge, England). 5784-6. PMID 16307145 DOI: 10.1039/B511338E  0.534
2004 Hsung RP, Cole KP. Chapter 3 The total synthesis of (-)-Arisugacina A Strategies and Tactics in Organic Synthesis. 4: 41-70. DOI: 10.1016/S1874-6004(04)80007-8  0.512
2003 Cole KP, Hsung RP. Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. Organic Letters. 5: 4843-6. PMID 14653688 DOI: 10.1021/Ol030115I  0.687
2003 Noland WE, Cole KP, Britton D. Five (1H-pyrrol-2-yl)pyridines. Acta Crystallographica. Section C, Crystal Structure Communications. 59: o263-7. PMID 12743410 DOI: 10.1107/S0108270103007042  0.301
2003 Shen HC, Wang J, Cole KP, McLaughlin MJ, Morgan CD, Douglas CJ, Hsung RP, Coverdale HA, Gerasyuto AI, Hahn JM, Liu J, Sklenicka HM, Wei LL, Zehnder LR, Zificsak CA. A formal [3 + 3] cycloaddition reaction. Improved reactivity using alpha,beta-unsaturated iminium salts and evidence for reversibility of 6pi-electron electrocyclic ring closure of 1-oxatrienes. The Journal of Organic Chemistry. 68: 1729-35. PMID 12608785 DOI: 10.1021/Jo020688T  0.711
2003 Hsung RP, Cole KP, Zehnder LR, Wang J, Wei LL, Yang XF, Coverdale HA. The total synthesis of (±)-arisugacin A Tetrahedron. 59: 311-324. DOI: 10.1016/S0040-4020(02)01524-7  0.817
2003 Hsung RP, Cole KP, Zehnder LR, Wang J, Wei L, Yang X, Coverdale HA. The Total Synthesis of (.+-.)-Arisugacin A (I). Cheminform. 34. DOI: 10.1002/chin.200320208  0.748
2003 Cole KP, Hsung RP. Synthetic Approaches to Phomactin A Chemtracts. 16: 811-818.  0.445
2002 McLaughlin MJ, Hsung RP, Cole KP, Hahn JM, Wang J. A novel and highly stereoselective approach to aza-spirocycles. A short total synthesis of 2-epi-(+/-)-perhydrohistrionicotoxin and an unprecedented decarboxylation of 2-pyrones. Organic Letters. 4: 2017-20. PMID 12049506 DOI: 10.1021/Ol020052O  0.822
2002 Cole KP, Hsung RP. The first enantioselective total synthesis of (-)-arisugacin A Tetrahedron Letters. 43: 8791-8793. DOI: 10.1016/S0040-4039(02)02094-4  0.675
2002 Wang J, Cole KP, Wei LL, Zehnder LR, Hsung RP. An unexpected retro-aldol-aldol in the AB-ring in the synthesis of (±)-arisugacin A Tetrahedron Letters. 43: 3337-3340. DOI: 10.1016/S0040-4039(02)00550-6  0.794
2001 Zehnder LR, Wei LL, Hsung RP, Cole KP, McLaughlin MJ, Shen HC, Sklenicka HM, Wang J, Zificsak CA. Stereoselective trans- and cis-dihydroxylations of 2H-pyranyl and dihydropyridinyl heterocycles synthesized from formal [3 + 3]-cycloaddition reactions of alpha,beta-unsaturated iminium ions with 1,3-dicarbonyl equivalents. Organic Letters. 3: 2141-4. PMID 11440564 DOI: 10.1021/Ol010034R  0.748
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