| Year |
Citation |
Score |
| 2020 |
Greite R, Derlin K, Hensen B, Thorenz A, Rong S, Chen R, Hellms S, Jang MS, Bräsen JH, Meier M, Willenberg I, Immenschuh S, Haller H, Luft FC, Panigrahy D, ... Hwang SH, et al. Early antihypertensive treatment and ischemia-induced acute kidney injury. American Journal of Physiology. Renal Physiology. PMID 32799675 DOI: 10.1152/Ajprenal.00078.2020 |
0.301 |
|
| 2020 |
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, et al. A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. Theranostics. 10: 4749-4761. PMID 32308747 DOI: 10.7150/Thno.43108 |
0.344 |
|
| 2020 |
Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Archives of Toxicology. PMID 32239239 DOI: 10.1007/S00204-020-02728-Z |
0.308 |
|
| 2020 |
Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 126: 109907. PMID 32114358 DOI: 10.1016/J.Biopha.2020.109907 |
0.35 |
|
| 2020 |
Sun CC, Zhang CY, Duan JX, Guan XX, Yang HH, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX, Liu SK, Zhang J. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochemical and Biophysical Research Communications. PMID 31973813 DOI: 10.1016/J.Bbrc.2019.12.131 |
0.323 |
|
| 2019 |
Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence. The Febs Journal. PMID 31646730 DOI: 10.1111/Febs.15105 |
0.344 |
|
| 2019 |
Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Frontiers in Pharmacology. 10: 1118. PMID 31611798 DOI: 10.3389/Fphar.2019.01118 |
0.368 |
|
| 2019 |
Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hwang SH, Jones RD, Hammock B, Yang GY. Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer Research. 39: 3651-3660. PMID 31262891 DOI: 10.21873/Anticanres.13513 |
0.345 |
|
| 2019 |
McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in Pharmacology. 10: 533. PMID 31214021 DOI: 10.3389/Fphar.2019.00533 |
0.346 |
|
| 2019 |
Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, et al. Inhibition of Soluble Epoxide Hydrolase Ameliorates Hyperhomocysteinemia-Induced Hepatic Steatosis by Enhancing β-oxidation of Fatty Acid in Mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 30789748 DOI: 10.1152/Ajpgi.00148.2018 |
0.348 |
|
| 2019 |
Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 30647111 DOI: 10.1073/Pnas.1803999116 |
0.318 |
|
| 2018 |
Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH. Development of Multitarget Agents Possessing Soluble Epoxide Hydrolase Inhibitory Activity. Prostaglandins & Other Lipid Mediators. PMID 30593866 DOI: 10.1016/J.Prostaglandins.2018.12.003 |
0.304 |
|
| 2018 |
Lakkappa N, Krishnamurthy PT, Pandareesh MD, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. PMID 30472438 DOI: 10.1016/J.Neuro.2018.11.010 |
0.321 |
|
| 2018 |
Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Molecular Pharmacology. PMID 29844231 DOI: 10.1124/Mol.118.111831 |
0.324 |
|
| 2018 |
Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally available soluble epoxide hydrolase/phosphodiesterase 4 dual inhibitor treats inflammatory pain. Journal of Medicinal Chemistry. PMID 29614224 DOI: 10.1021/Acs.Jmedchem.7B01804 |
0.334 |
|
| 2018 |
Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L. Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. Kidney & Blood Pressure Research. 43: 329-349. PMID 29529602 DOI: 10.1159/000487902 |
0.304 |
|
| 2018 |
Kala P, Sedláková L, Škaroupková P, Kopkan L, Vaňourková Z, Táborský M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovský V, Imig JD, Červenka L. Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula. Physiological Research. PMID 29527914 DOI: 10.33549/Physiolres.933757 |
0.317 |
|
| 2018 |
Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. PMID 29366648 DOI: 10.1016/J.Bmcl.2018.01.003 |
0.383 |
|
| 2018 |
Bastan I, Ge XN, Dileepan M, Greenberg YG, Guedes AG, Hwang SH, Hammock BD, Washabau RJ, Rao SP, Sriramarao P. Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation. Journal of Leukocyte Biology. PMID 29345370 DOI: 10.1002/Jlb.3Ma1017-423R |
0.344 |
|
| 2018 |
Zimmermann M, Hwang SH, Hammock BD, Cimino G, Henderson PT. Abstract B06: Enhancement of checkpoint inhibitor efficacy by combination treatment with a novel COX2/sEH dual inhibitor Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-B06 |
0.345 |
|
| 2017 |
Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, et al. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Anti-tumor Efficacy of Cisplatin. Molecular Cancer Therapeutics. PMID 29284644 DOI: 10.1158/1535-7163.Mct-16-0818 |
0.332 |
|
| 2017 |
Li J, Zhou Y, Wang H, Gao Y, Li L, Hwang SH, Ji X, Hammock BD. COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor. Oncotarget. 8: 87353-87363. PMID 29152086 DOI: 10.18632/Oncotarget.20928 |
0.304 |
|
| 2016 |
Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorganic & Medicinal Chemistry Letters. PMID 28025003 DOI: 10.1016/J.Bmcl.2016.12.002 |
0.317 |
|
| 2016 |
Liao J, Xia R, Yang J, Li H, Xu D, Wang X, You X, Hwang SH, Hammock B, Yang G. Abstract LB-299: Enhanced inhibitory effects on mutant KrasG12D-initiated murine pancreatic carcinoma growth in Fat-1 transgenic mice treated with soluble epoxide hydrolase inhibitor t-AUCB Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-299 |
0.351 |
|
| 2015 |
Liao J, Hwang SH, Li H, Yang Y, Yang J, Wecksler AT, Liu JY, Hammock BD, Yang GY. Inhibition of mutant Kras(G12D) -initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. Cancer Letters. PMID 26683769 DOI: 10.1016/J.Canlet.2015.11.042 |
0.348 |
|
| 2015 |
Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochemical Pharmacology. PMID 26494425 DOI: 10.1016/J.Bcp.2015.10.013 |
0.328 |
|
| 2015 |
Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb NH. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins & Other Lipid Mediators. PMID 26117215 DOI: 10.1016/J.Prostaglandins.2015.06.005 |
0.347 |
|
| 2015 |
?ervenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J. Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. Physiological Research / Academia Scientiarum Bohemoslovaca. PMID 26047375 DOI: 10.33549/Physiolres.932977 |
0.325 |
|
| 2015 |
Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. American Journal of Physiology. Renal Physiology. 308: F131-9. PMID 25377915 DOI: 10.1152/Ajprenal.00531.2014 |
0.349 |
|
| 2015 |
Yang J, Bratt J, Franzi L, Liu JY, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. American Journal of Respiratory Cell and Molecular Biology. 52: 46-55. PMID 24922186 DOI: 10.1165/Rcmb.2013-0440Oc |
0.301 |
|
| 2014 |
Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clinical and Experimental Pharmacology & Physiology. 41: 1003-13. PMID 25224811 DOI: 10.1111/1440-1681.12310 |
0.343 |
|
| 2014 |
Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, et al. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. Journal of Medicinal Chemistry. 57: 7016-30. PMID 25079952 DOI: 10.1021/Jm500694P |
0.312 |
|
| 2014 |
Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: 11127-32. PMID 25024195 DOI: 10.1073/Pnas.1410432111 |
0.324 |
|
| 2014 |
Sarnpitak P, Mujumdar P, Morisseau C, Hwang SH, Hammock B, Iurchenko V, Zozulya S, Gavalas A, Geronikaki A, Ivanenkov Y, Krasavin M. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. European Journal of Medicinal Chemistry. 84: 160-72. PMID 25016374 DOI: 10.1016/J.Ejmech.2014.07.023 |
0.35 |
|
| 2014 |
Sun D, Cuevas AJ, Gotlinger K, Hwang SH, Hammock BD, Schwartzman ML, Huang A. Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1146-53. PMID 24561863 DOI: 10.1152/Ajpheart.00920.2013 |
0.307 |
|
| 2014 |
Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anti-Cancer Drugs. 25: 433-46. PMID 24525589 DOI: 10.1097/Cad.0000000000000079 |
0.315 |
|
| 2013 |
Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. Plos One. 8: e80922. PMID 24349022 DOI: 10.1371/Journal.Pone.0080922 |
0.31 |
|
| 2013 |
Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3732-7. PMID 23726028 DOI: 10.1016/J.Bmcl.2013.05.011 |
0.356 |
|
| 2013 |
Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorganic & Medicinal Chemistry Letters. 23: 3818-21. PMID 23684894 DOI: 10.1016/J.Bmcl.2013.04.083 |
0.369 |
|
| 2013 |
Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sciences. 92: 1145-50. PMID 23651659 DOI: 10.1016/J.Lfs.2013.04.014 |
0.337 |
|
| 2013 |
Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 110: 6530-5. PMID 23553837 DOI: 10.1073/Pnas.1304321110 |
0.331 |
|
| 2013 |
Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 48: 619-27. PMID 23291046 DOI: 10.1016/J.Ejps.2012.12.013 |
0.383 |
|
| 2013 |
Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. European Journal of Pharmacology. 700: 93-101. PMID 23276668 DOI: 10.1016/J.Ejphar.2012.12.015 |
0.301 |
|
| 2013 |
Lee KSS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase Analytical Biochemistry. 434: 259-268. PMID 23219719 DOI: 10.1016/J.Ab.2012.11.015 |
0.337 |
|
| 2013 |
Kundu S, Roome T, Bhattacharjee A, Carnevale KA, Yakubenko VP, Zhang R, Hwang SH, Hammock BD, Cathcart MK. Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo. Journal of Lipid Research. 54: 436-47. PMID 23160182 DOI: 10.1194/Jlr.M031914 |
0.381 |
|
| 2013 |
Varcabova S, Huskova Z, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Kitada K, Cervenka L. Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system. Clinical and Experimental Pharmacology & Physiology. 40: 273-81. PMID 23039246 DOI: 10.1111/1440-1681.12018 |
0.317 |
|
| 2012 |
Kopkan L, Husková Z, Sporková A, Varcabová Š, Honetschlägerová Z, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Kramer HJ, Bürgelová M, Vojtíšková A, Kujal P, Vernerová Z, Červenka L. Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. Kidney & Blood Pressure Research. 35: 595-607. PMID 22948718 DOI: 10.1159/000339883 |
0.35 |
|
| 2012 |
Neckár J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-I-ylureido)cyclohexyloxy] benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension Clinical Science. 122: 513-525. PMID 22324471 DOI: 10.1042/Cs20110622 |
0.358 |
|
| 2012 |
Iyer A, Kauter K, Alam MA, Hwang SH, Morisseau C, Hammock BD, Brown L. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Experimental Diabetes Research. 2012: 758614. PMID 22007192 DOI: 10.1155/2012/758614 |
0.305 |
|
| 2012 |
Ulu A, Appt S, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. British Journal of Pharmacology. 165: 1401-12. PMID 21880036 DOI: 10.1111/J.1476-5381.2011.01641.X |
0.331 |
|
| 2011 |
Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biology & Therapy. 12: 827-36. PMID 21878748 DOI: 10.4161/Cbt.12.9.17680 |
0.327 |
|
| 2011 |
Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicology and Applied Pharmacology. 255: 200-6. PMID 21741984 DOI: 10.1016/J.Taap.2011.06.017 |
0.33 |
|
| 2011 |
Liu X, Li C, Gebremedhin D, Hwang SH, Hammock BD, Falck JR, Roman RJ, Harder DR, Koehler RC. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo American Journal of Physiology - Heart and Circulatory Physiology. 301: H373-H381. PMID 21602473 DOI: 10.1152/Ajpheart.00745.2010 |
0.306 |
|
| 2011 |
Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of Medicinal Chemistry. 54: 3037-50. PMID 21434686 DOI: 10.1021/Jm2001376 |
0.374 |
|
| 2011 |
Honetschlägerová Z, Z Husková Z, Vaňourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Červenka L, Kopkan L. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. The Journal of Physiology. 589: 207-19. PMID 21078594 DOI: 10.1113/Jphysiol.2010.199505 |
0.301 |
|
| 2010 |
Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, Hammock BD. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 40: 222-38. PMID 20359531 DOI: 10.1016/J.Ejps.2010.03.018 |
0.365 |
|
| 2010 |
Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochemical Pharmacology. 79: 880-7. PMID 19896470 DOI: 10.1016/J.Bcp.2009.10.025 |
0.38 |
|
| 2010 |
Chaudhary KR, Abukhashim M, Hwang SH, Hammock BD, Seubert JM. Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology. 55: 67-73. PMID 19834332 DOI: 10.1097/Fjc.0B013E3181C37D69 |
0.336 |
|
| 2009 |
Li N, Liu JY, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. Journal of Molecular and Cellular Cardiology. 47: 835-45. PMID 19716829 DOI: 10.1016/J.Yjmcc.2009.08.017 |
0.333 |
|
| 2009 |
Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Molecular Cancer Therapeutics. 8: 2193-203. PMID 19671760 DOI: 10.1158/1535-7163.Mct-09-0119 |
0.374 |
|
| 2009 |
Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. British Journal of Pharmacology. 156: 284-96. PMID 19154430 DOI: 10.1111/J.1476-5381.2008.00009.X |
0.353 |
|
| 2007 |
Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD. Orally bioavailable potent soluble epoxide hydrolase inhibitors. Journal of Medicinal Chemistry. 50: 3825-40. PMID 17616115 DOI: 10.1021/Jm070270T |
0.346 |
|
| 2006 |
Hwang SH, Morisseau C, Do Z, Hammock BD. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 5773-7. PMID 16949285 DOI: 10.1016/J.Bmcl.2006.08.078 |
0.311 |
|
| 2004 |
Hwang SH, Lehman A, Cong X, Olmstead MM, Lam KS, Lebrilla CB, Kurth MJ. OBOC small-molecule combinatorial library encoded by halogenated mass-tags. Organic Letters. 6: 3829-32. PMID 15469360 DOI: 10.1021/Ol048408E |
0.439 |
|
| 2004 |
Hwang SH, Olmstead MM, Kurth MJ. Solid-phase synthesis of an isoxazolinopyrrole library. Journal of Combinatorial Chemistry. 6: 142-8. PMID 14714998 DOI: 10.1021/Cc034023W |
0.462 |
|
| 2002 |
Hwang SH, Kurth MJ. Versatile "traceless" sulfone linker for SPOS: preparation of isoxazolinopyrrole 2-carboxylates. The Journal of Organic Chemistry. 67: 6564-7. PMID 12201785 DOI: 10.1021/Jo016377K |
0.465 |
|
| 2002 |
Kwon HJ, Smith WC, Scharon AJ, Hwang SH, Kurth MJ, Shen B. C-O bond formation by polyketide synthases. Science (New York, N.Y.). 297: 1327-30. PMID 12193782 DOI: 10.1126/Science.1073175 |
0.437 |
|
| 2002 |
Hwang SH, Kurth MJ. 1,3-Dipolar cycloaddition of nitrile oxides to 1-phenylsulfonyl-1,3-butadienes: Synthesis of 3-(4,5-dihydroisoxazol-5-yl)pyrroles Tetrahedron Letters. 43: 53-56. DOI: 10.1016/S0040-4039(01)02069-X |
0.451 |
|
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