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Sangram Sign Sisodia, PhD - Publications

Affiliations: 
Neurobiology University of Chicago, Chicago, IL 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=30
Website:
http://pps.bsd.uchicago.edu/faculty/sangram_sisodia.html

230 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. Iscience. 24: 102942. PMID 34430820 DOI: 10.1016/j.isci.2021.102942  0.304
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313  0.338
2020 Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371  0.384
2020 Dodiya HB, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, Sisodia SS. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice. Scientific Reports. 10: 8183. PMID 32424118 DOI: 10.1038/s41598-020-64797-5  0.356
2020 Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative Evidence for a Role of APH1B T27I Variant in Alzheimer's Disease. Human Molecular Genetics. PMID 31995180 DOI: 10.1093/Hmg/Ddaa017  0.383
2019 Ortega-Martinez S, Palla N, Zhang X, Lipman E, Sisodia SS. Deficits in Enrichment-Dependent neurogenesis and enhanced Anxiety behaviors mediated by expression of Alzheimer's disease-linked PS1 variants are rescued by Microglial Depletion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31217332 DOI: 10.1523/JNEUROSCI.0884-19.2019  0.46
2019 Dodiya HB, Kuntz T, Shaik SM, Baufeld C, Leibowitz J, Zhang X, Gottel N, Zhang X, Butovsky O, Gilbert JA, Sisodia SS. Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. The Journal of Experimental Medicine. PMID 31097468 DOI: 10.1084/Jem.20182386  0.403
2019 Dodiya HB, Kuntz T, Shaik SM, Baufeld C, Leibowitz J, Zhang X, Gottel N, Zhang X, Butovsky O, Gilbert JA, Sisodia SS. P1-216: SEX-SPECIFIC PERTURBATIONS IN CEREBRAL AMYLOIDOSIS AND MICROGLIA PHENOTYPES IN ANTIBIOTIC-TREATED APPSWE /PS1L166P TRANSGENIC MICE Alzheimer's & Dementia. 15: P319-P319. DOI: 10.1016/J.Jalz.2019.06.771  0.311
2018 Sisodia SS. Ec-03-03: Gut Microbiome Alterations In Alzheimer'S Disease: Preclinical Evidence Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2767  0.374
2017 Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease. Scientific Reports. 7: 10411. PMID 28874832 DOI: 10.1038/S41598-017-11047-W  0.413
2017 Füger P, Hefendehl JK, Veeraraghavalu K, Wendeln AC, Schlosser C, Obermüller U, Wegenast-Braun BM, Neher JJ, Martus P, Kohsaka S, Thunemann M, Feil R, Sisodia SS, Skodras A, Jucker M. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nature Neuroscience. PMID 28846081 DOI: 10.1038/Nn.4631  0.375
2016 Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Scientific Reports. 6: 30028. PMID 27443609 DOI: 10.1038/Srep30028  0.389
2016 Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence that the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. The Journal of Biological Chemistry. PMID 26887941 DOI: 10.1074/Jbc.C115.701649  0.342
2015 Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, et al. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. The Journal of Biological Chemistry. 290: 18609-20. PMID 26085104 DOI: 10.1074/Jbc.M115.647180  0.359
2014 Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. The Journal of Biological Chemistry. 289: 34851-61. PMID 25352592 DOI: 10.1074/Jbc.M114.609636  0.415
2014 DeBoer SR, Dolios G, Wang R, Sisodia SS. Differential release of β-amyloid from dendrite- versus axon-targeted APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12313-27. PMID 25209273 DOI: 10.1523/JNEUROSCI.2255-14.2014  0.722
2014 Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3668-73. PMID 24599465 DOI: 10.1523/Jneurosci.5079-13.2014  0.472
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/Bi401537V  0.407
2013 Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors. Molecular Neurodegeneration. 8: 41. PMID 24138759 DOI: 10.1186/1750-1326-8-41  0.563
2013 Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/Science.1235505  0.405
2013 Veeraraghavalu K, Sisodia SS. Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 9148-53. PMID 23674689 DOI: 10.1073/pnas.1302106110  0.416
2012 Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8633-48. PMID 22723704 DOI: 10.1523/Jneurosci.0556-12.2012  0.415
2012 Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proceedings of the National Academy of Sciences of the United States of America. 109: 8534-9. PMID 22586122 DOI: 10.1073/Pnas.1202691109  0.324
2012 Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine. 2: a006270. PMID 22553493 DOI: 10.1101/Cshperspect.A006270  0.463
2012 Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Experimental Brain Research. 217: 353-64. PMID 21960299 DOI: 10.1007/S00221-011-2870-1  0.437
2011 Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. Plos One. 6: e28179. PMID 22140537 DOI: 10.1371/Journal.Pone.0028179  0.585
2011 Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. The Journal of Biological Chemistry. 286: 21440-9. PMID 21454611 DOI: 10.1074/Jbc.M110.193326  0.324
2010 Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic gamma-secretase activity of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 107: 21435-40. PMID 21115843 DOI: 10.1073/Pnas.1013246107  0.386
2010 Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15677-85. PMID 21084623 DOI: 10.1523/Jneurosci.4464-10.2010  0.451
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Sisodia SS, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018  0.449
2010 Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6903-15. PMID 20484632 DOI: 10.1523/JNEUROSCI.0527-10.2010  0.528
2010 Veeraraghavalu K, Choi SH, Sisodia SS. Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis. Neuro-Degenerative Diseases. 7: 46-9. PMID 20160458 DOI: 10.1159/000283482  0.577
2010 Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nature Neuroscience. 13: 190-6. PMID 20037574 DOI: 10.1038/Nn.2476  0.389
2010 Lee J, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Sisodia SS, Cuervo AM, Nixon RA. P2-271: Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy Alzheimer's & Dementia. 6: S393-S394. DOI: 10.1016/J.Jalz.2010.05.1321  0.319
2009 Choi SH, Li Y, Parada LF, Sisodia SS. Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Molecular Neurodegeneration. 4: 52. PMID 20025751 DOI: 10.1186/1750-1326-4-52  0.48
2009 Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angewandte Chemie (International Ed. in English). 48: 1487-9. PMID 19152390 DOI: 10.1002/Anie.200805225  0.468
2009 Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry. 284: 2967-77. PMID 19036728 DOI: 10.1074/Jbc.M807269200  0.408
2009 Renzi F, Torres-Arancivia C, Zhang X, Li Y, Sisodia S. Structure Of Gamma-secretase Reveals An Active Site Facing An Internal Membrane Cavity Biophysical Journal. 96: 3-5. DOI: 10.1016/J.Bpj.2008.12.3805  0.339
2009 Meier M, Kennedy-Darling J, Choi SH, Sisodia S, Ismagilov RF. Amyloid Peptide Aggregation In Plugs Formed By Microfluidics Biophysical Journal. 96: 218a. DOI: 10.1016/J.Bpj.2008.12.1910  0.339
2008 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/Jneurosci.2635-08.2008  0.392
2008 Mirnics K, Norstrom EM, Garbett K, Choi SH, Zhang X, Ebert P, Sisodia SS. Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. Molecular Neurodegeneration. 3: 14. PMID 18834536 DOI: 10.1186/1750-1326-3-14  0.559
2008 Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron. 59: 568-80. PMID 18760694 DOI: 10.1016/J.Neuron.2008.07.033  0.557
2008 Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200  0.36
2008 Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP. Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiology of Disease. 29: 316-26. PMID 17980611 DOI: 10.1016/j.nbd.2007.09.005  0.518
2007 Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW. Biogenesis of gamma-secretase early in the secretory pathway. The Journal of Cell Biology. 179: 951-63. PMID 18056412 DOI: 10.1083/Jcb.200709012  0.441
2007 Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13092-7. PMID 18045903 DOI: 10.1523/JNEUROSCI.4244-07.2007  0.461
2007 Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. The Journal of Biological Chemistry. 282: 25453-63. PMID 17613531 DOI: 10.1074/Jbc.M701590200  0.317
2007 Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7011-20. PMID 17596450 DOI: 10.1523/Jneurosci.4272-06.2007  0.488
2007 Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7006-10. PMID 17596449 DOI: 10.1523/Jneurosci.1919-07.2007  0.57
2006 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/J.Neuron.2006.10.035  0.356
2006 Thinakaran G, Sisodia SS. Presenilins and Alzheimer disease: the calcium conspiracy. Nature Neuroscience. 9: 1354-5. PMID 17066063 DOI: 10.1038/Nn1106-1354  0.318
2006 Kim SH, Tang YP, Sisodia SS. Abeta star: a light onto synaptic dysfunction? Nature Medicine. 12: 760-1; discussion 76. PMID 16829934 DOI: 10.1038/nm0706-760  0.351
2006 Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 103: 1941-6. PMID 16449386 DOI: 10.1073/Pnas.0510708103  0.418
2006 Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proceedings of the National Academy of Sciences of the United States of America. 103: 1936-40. PMID 16449385 DOI: 10.1073/Pnas.0510710103  0.459
2006 Lazarov O, Peterson LD, Peterson DA, Sisodia SS. Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 429-34. PMID 16407539 DOI: 10.1523/JNEUROSCI.3961-05.2006  0.449
2006 Chauhan NB, Sandoval JS, Sisodia SS. P4-088: Aged garlic extract reduces the secretion of Alzheimer’s beta-amyloid peptides in N2a cells transfected with human “Swedish” APP695 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1826  0.346
2005 Unger T, Korade Z, Lazarov O, Terrano D, Schor NF, Sisodia SS, Mirnics K. Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 13: 1041-51. PMID 16319296 DOI: 10.1097/00019442-200512000-00003  0.396
2005 Unger T, Korade Z, Lazarov O, Terrano D, Sisodia SS, Mirnics K. True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice. Methods (San Diego, Calif.). 37: 261-73. PMID 16308155 DOI: 10.1016/J.Ymeth.2005.09.005  0.31
2005 Perez SE, Lazarov O, Koprich JB, Chen EY, Rodriguez-Menendez V, Lipton JW, Sisodia SS, Mufson EJ. Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10220-9. PMID 16267229 DOI: 10.1523/Jneurosci.2773-05.2005  0.462
2005 Kim SH, Sisodia SS. Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. The Journal of Biological Chemistry. 280: 41953-66. PMID 16234243 DOI: 10.1074/jbc.M509070200  0.359
2005 Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF. P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiology of Disease. 20: 969-85. PMID 16006137 DOI: 10.1016/J.Nbd.2005.06.004  0.319
2005 Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. The Journal of Biological Chemistry. 280: 25892-900. PMID 15886206 DOI: 10.1074/Jbc.M503570200  0.364
2005 Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 120: 701-13. PMID 15766532 DOI: 10.1016/J.Cell.2005.01.015  0.451
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005  0.758
2005 Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS. Presenilin-1-dependent transcriptome changes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1571-8. PMID 15703411 DOI: 10.1523/Jneurosci.4145-04.2005  0.436
2005 Parent AT, Barnes NY, Taniguchi Y, Thinakaran G, Sisodia SS. Presenilin attenuates receptor-mediated signaling and synaptic function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1540-9. PMID 15703408 DOI: 10.1523/Jneurosci.3850-04.2005  0.369
2005 Kim SH, Sisodia SS. A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. The Journal of Biological Chemistry. 280: 1992-2001. PMID 15537629 DOI: 10.1074/jbc.M412404200  0.353
2004 Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. The Journal of Biological Chemistry. 279: 48615-9. PMID 15456788 DOI: 10.1074/Jbc.C400396200  0.375
2004 Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Müller U. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members Embo Journal. 23: 4106-4115. PMID 15385965 DOI: 10.1038/Sj.Emboj.7600390  0.453
2004 Louvi A, Sisodia SS, Grove EA. Presenilin 1 in migration and morphogenesis in the central nervous system. Development (Cambridge, England). 131: 3093-105. PMID 15163631 DOI: 10.1242/dev.01191  0.332
2004 Mirnics K, Mirnics ZK, Portugal CF, Terrano D, Lazarov O, Douglass KC, Lewis DA, Schor NF, Sisodia SS. P4-266 Brain transcriptome changes in presenilin-1 mutant mice Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81824-4  0.305
2004 Müller U, Anliker B, Heber S, Fuhrmann M, Kretzschmar H, Sisodia S, Herms J. O4-04-07 Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP-family members Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80278-1  0.309
2004 Lazarov O, Robinson J, Tang Y, Hairston IS, Lee VM, Hersh LB, Sapolsky RM, Sisodia SS. O2-03-01 Reduced amyloid deposition and enhanced Aβ-catabolism in FAD-linked APPSWE/PS1ΔE9 mice following exposure Neurobiology of Aging. 25: S36. DOI: 10.1016/S0197-4580(04)80119-2  0.356
2003 Mirnics ZK, Mirnics K, Terrano D, Lewis DA, Sisodia SS, Schor NF. DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes. Molecular Psychiatry. 8: 863-78. PMID 14515137 DOI: 10.1038/Sj.Mp.4001389  0.371
2003 Taniguchi Y, Kim SH, Sisodia SS. Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC). The Journal of Biological Chemistry. 278: 30425-8. PMID 12840034 DOI: 10.1074/jbc.C300239200  0.373
2003 Kim SH, Ikeuchi T, Yu C, Sisodia SS. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. The Journal of Biological Chemistry. 278: 33992-4002. PMID 12821663 DOI: 10.1074/jbc.M305834200  0.409
2003 Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7  0.418
2003 Ikeuchi T, Sisodia SS. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. The Journal of Biological Chemistry. 278: 7751-4. PMID 12551931 DOI: 10.1074/jbc.C200711200  0.349
2003 Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase". The Journal of Biological Chemistry. 278: 7010-8. PMID 12493731 DOI: 10.1074/jbc.M209252200  0.404
2003 Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 3446-54. PMID 12435726 DOI: 10.1074/Jbc.M209065200  0.42
2002 Trojanowski JQ, Lieberburg I, Lemere C, Gandy S, Bush A, Frangione B, Citron M, Li YM, Lee VMY, Sisodia S, Clark C, Karlawish J. Emerging Alzheimer's disease therapies: Focusing on the future Neurobiology of Aging. 23: 985-990. PMID 12470793 DOI: 10.1016/S0197-4580(02)00123-9  0.317
2002 Lazarov O, Lee M, Peterson DA, Sisodia SS. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9785-93. PMID 12427834 DOI: 10.1523/Jneurosci.22-22-09785.2002  0.436
2002 Ikeuchi T, Sisodia SS. Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities. Neuromolecular Medicine. 1: 43-54. PMID 12025815 DOI: 10.1385/NMM:1:1:43  0.37
2002 Mirinics ZK, Calafat J, Udby L, Lovelock J, Kjeldsen L, Rothermund K, Sisodia SS, Borregaard N, Corey SJ. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Blood Cells, Molecules & Diseases. 28: 28-38. PMID 11987239 DOI: 10.1006/bcmd.2002.0486  0.424
2002 Sisodia SS, St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nature Reviews. Neuroscience. 3: 281-90. PMID 11967558 DOI: 10.1038/nrn785  0.427
2002 Sisodia SS. Biomedicine. A cargo receptor mystery APParently solved? Science (New York, N.Y.). 295: 805-7. PMID 11823626 DOI: 10.1126/science.1069661  0.364
2002 Borchelt DR, Lee MK, Gonzales V, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice. Neurobiology of Aging. 23: 171-7. PMID 11804700 DOI: 10.1016/S0197-4580(01)00280-9  0.561
2002 Kalback W, Watson MD, Kokjohn TA, Kuo YM, Weiss N, Luehrs DC, Lopez J, Brune D, Sisodia SS, Staufenbiel M, Emmerling M, Roher AE. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry. 41: 922-8. PMID 11790115 DOI: 10.1021/bi015685+  0.452
2002 Kim SH, Creemers JW, Chu S, Thinakaran G, Sisodia SS. Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides. The Journal of Biological Chemistry. 277: 1872-7. PMID 11709554 DOI: 10.1074/Jbc.M108739200  0.314
2001 Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never more enigmatic. Trends in Neurosciences. 24: S2-6. PMID 11881741 DOI: 10.1016/S0166-2236(00)01987-1  0.408
2001 Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. The Journal of Biological Chemistry. 276: 43756-60. PMID 11583985 DOI: 10.1074/Jbc.C100410200  0.318
2001 Kim SH, Leem JY, Lah JJ, Slunt HH, Levey AI, Thinakaran G, Sisodia SS. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. The Journal of Biological Chemistry. 276: 43343-50. PMID 11564743 DOI: 10.1074/Jbc.M108245200  0.412
2001 Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG. Post-translational processing of β-secretase (β -amyloid-converting enzyme) and its ectodomain shedding: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production Journal of Biological Chemistry. 276: 10879-10887. PMID 11152688 DOI: 10.1074/Jbc.M009899200  0.429
2001 Sisodia SS, Tanzi RE. Guest editor's introduction: Alzheimer's disease clinical, biological, and therapeutic perspectives Journal of Molecular Neuroscience. 17: 99. DOI: 10.1385/JMN:17:2:99  0.33
2000 Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. Journal of Molecular Neuroscience : Mn. 15: 189-204. PMID 11303783 DOI: 10.1385/JMN:15:3:189  0.38
2000 Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, Lynn DG, Meredith SC, Sisodia SS. Familial British dementia: expression and metabolism of BRI. Annals of the New York Academy of Sciences. 920: 93-9. PMID 11193182 DOI: 10.1111/J.1749-6632.2000.Tb06909.X  0.364
2000 Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences. 920: 179-91. PMID 11193148 DOI: 10.1111/J.1749-6632.2000.Tb06920.X  0.648
2000 Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nature Cell Biology. 2: 863-70. PMID 11146649 DOI: 10.1038/35046500  0.412
2000 Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2  0.495
2000 Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, Kretzschmar H, Von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members Journal of Neuroscience. 20: 7951-7963. PMID 11050115 DOI: 10.1523/Jneurosci.20-21-07951.2000  0.447
2000 Sisodia SS. Neuroscience. An accomplice for gamma-secretase brought into focus. Science (New York, N.Y.). 289: 2296-7. PMID 11041797 DOI: 10.1126/science.289.5488.2296  0.375
2000 Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiology of Disease. 7: 54-63. PMID 10671322 DOI: 10.1006/Nbdi.1999.0271  0.403
2000 Sisodia SS, Martys SKJ, Wang R, Sklar J, Berechid B, Nye J, Thinakaran G. Molecular Mechanisms of Familial Alzheimer's Disease Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A129A  0.352
2000 Sato N, Kim S, Veselits M, Chu S, Sisodia SS, Thinakaran G. Influence of PS and FAD-linked PS variants on the mammalian unfolded protein response Neurobiology of Aging. 21: 259. DOI: 10.1016/S0197-4580(00)83117-6  0.31
2000 Sisodia S, Kim S, Martys J, Naruse S, Chu S, Nye J, Berechid B, Sklar J. The roles of presenilins in APP processing Neurobiology of Aging. 21: 140. DOI: 10.1016/S0197-4580(00)82427-6  0.306
1999 Sisodia SS. Alzheimer's disease: perspectives for the new millennium. The Journal of Clinical Investigation. 104: 1169-70. PMID 10545514 DOI: 10.1172/JCI8508  0.426
1999 Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Lynn DG, Thinakaran G, Meredith SC, Sisodia SS. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nature Neuroscience. 2: 984-8. PMID 10526337 DOI: 10.1038/14783  0.344
1999 Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nature Neuroscience. 2: 695-7. PMID 10412057 DOI: 10.1038/11154  0.482
1999 Sisodia SS, Kim SH, Thinakaran G. Function and dysfunction of the presenilins. American Journal of Human Genetics. 65: 7-12. PMID 10364510 DOI: 10.1086/302475  0.432
1999 Parent A, Linden DJ, Sisodia SS, Borchelt DR. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiology of Disease. 6: 56-62. PMID 10078973 DOI: 10.1006/Nbdi.1998.0207  0.377
1999 Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 96: 742-7. PMID 9892704 DOI: 10.1073/Pnas.96.2.742  0.444
1998 Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842 DOI: 10.1007/978-1-4615-4869-0_9  0.58
1998 Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annual Review of Genetics. 32: 461-93. PMID 9928488 DOI: 10.1146/Annurev.Genet.32.1.461  0.568
1998 Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6  0.543
1998 Buxbaum JD, Thinakaran G, Koliatsos V, O'Callahan J, Slunt HH, Price DL, Sisodia SS. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9629-37. PMID 9822724 DOI: 10.1523/Jneurosci.18-23-09629.1998  0.565
1998 Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: the human illness and transgenic models. Science (New York, N.Y.). 282: 1079-83. PMID 9804539 DOI: 10.1126/Science.282.5391.1079  0.536
1998 Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathology (Zurich, Switzerland). 8: 735-57. PMID 9804381 DOI: 10.1111/J.1750-3639.1998.Tb00198.X  0.572
1998 Sisodia SS. Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial? Cell. 95: 1-4. PMID 9778239 DOI: 10.1016/S0092-8674(00)81743-2  0.353
1998 Sisodia SS, Gallagher M. A role for the beta-amyloid precursor protein in memory? Proceedings of the National Academy of Sciences of the United States of America. 95: 12074-6. PMID 9770440 DOI: 10.1073/PNAS.95.21.12074  0.449
1998 Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiology of Disease. 5: 27-35. PMID 9702785 DOI: 10.1006/Nbdi.1998.0178  0.616
1998 Price DL, Sisodia SS, Borchelt DR. Alzheimer disease--when and why? Nature Genetics. 19: 314-6. PMID 9697686 DOI: 10.1038/1196  0.523
1998 Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiology of Disease. 4: 438-53. PMID 9666482 DOI: 10.1006/Nbdi.1998.0171  0.56
1998 Bergin A, Kim G, Price DL, Sisodia SS, Lee MK, Rabin BA. Corrigendum to: 'Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron' Gene. 213: 227. PMID 9630645 DOI: 10.1016/S0378-1119(98)00226-1  0.453
1998 Lyckman AW, Confaloni AM, Thinakaran G, Sisodia SS, Moya KL. Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. The Journal of Biological Chemistry. 273: 11100-6. PMID 9556595 DOI: 10.1074/Jbc.273.18.11100  0.436
1998 Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, ... Sisodia SS, et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine. 4: 447-51. PMID 9546791 DOI: 10.1038/Nm0498-447  0.461
1998 Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20: 603-9. PMID 9539132 DOI: 10.1016/S0896-6273(00)80998-8  0.595
1998 Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annual Review of Neuroscience. 21: 479-505. PMID 9530504 DOI: 10.1146/annurev.neuro.21.1.479  0.556
1997 Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue Neurologique. 153: 484-95. PMID 9683997  0.547
1997 von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiology of Aging. 18: 661-9. PMID 9461064 DOI: 10.1016/S0197-4580(97)00151-6  0.532
1997 Bergin A, Kim G, Price DL, Sisodia SS, Lee MK, Rabin BA. Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron. Gene. 204: 47-53. PMID 9434164 DOI: 10.1016/S0378-1119(97)00510-6  0.489
1997 Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19: 939-45. PMID 9354339 DOI: 10.1016/S0896-6273(00)80974-5  0.623
1997 Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. The Journal of Biological Chemistry. 272: 28415-22. PMID 9353300 DOI: 10.1074/Jbc.272.45.28415  0.563
1997 Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR. Endoproteolytic processing and stabilization of wild-type and mutant presenilin. The Journal of Biological Chemistry. 272: 24536-41. PMID 9305918 DOI: 10.1074/Jbc.272.39.24536  0.519
1997 Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Human Molecular Genetics. 6: 1535-41. PMID 9285791 DOI: 10.1093/Hmg/6.9.1535  0.595
1997 Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Medicine. 3: 756-60. PMID 9212102 DOI: 10.1038/Nm0797-756  0.588
1997 Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 387: 288-92. PMID 9153393 DOI: 10.1038/387288a0  0.567
1997 Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 5090-4. PMID 9144195 DOI: 10.1073/Pnas.94.10.5090  0.327
1997 Li HL, Roch JM, Sundsmo M, Otero D, Sisodia S, Thomas R, Saitoh T. Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease. Journal of Neurobiology. 32: 469-80. PMID 9110259 DOI: 10.1002/(Sici)1097-4695(199705)32:5<469::Aid-Neu3>3.0.Co;2-3  0.365
1997 Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 3748-52. PMID 9108049 DOI: 10.1073/Pnas.94.8.3748  0.372
1997 Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18: 327-38. PMID 9052802 DOI: 10.1016/S0896-6273(00)80272-X  0.638
1997 Zhao B, Chrest FJ, Horton WE, Sisodia SS, Kusiak JW. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. Journal of Neuroscience Research. 47: 253-63. PMID 9039647 DOI: 10.1002/(SICI)1097-4547(19970201)47:3<253::AID-JNR3>3.0.CO;2-H  0.401
1997 Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896  0.329
1997 Marquez-Sterling NR, Lo AC, Sisodia SS, Koo EH. Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 140-51. PMID 8987743 DOI: 10.1523/Jneurosci.17-01-00140.1997  0.348
1997 Saporito-irwin SM, Thinakaran G, Ruffini L, Sisodia SS, Nostrand WEV. Amyloid $sZ-protein stimulates parallel increases in cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells Amyloid. 4: 54-60. DOI: 10.3109/13506129708995270  0.408
1996 Price DL, Borchelt DR, Wong PC, Pardo CA, Thinakaran G, Lee MK, Cleveland DW, Sisodia SS. Neurodegenerative diseases and model systems. Cold Spring Harbor Symposia On Quantitative Biology. 61: 725-38. PMID 9246498 DOI: 10.1101/Sqb.1996.061.01.072  0.58
1996 Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, Price DL. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genetic Analysis : Biomolecular Engineering. 13: 159-63. PMID 9117892 DOI: 10.1016/S1050-3862(96)00167-2  0.531
1996 Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 93: 14940-4. PMID 8962160 DOI: 10.1073/Pnas.93.25.14940  0.398
1996 Price DL, Becher MW, Wong PC, Borchelt DR, Lee MK, Sisodia SS. Inherited neurodegenerative diseases and transgenic models. Brain Pathology (Zurich, Switzerland). 6: 467-80. PMID 8944317 DOI: 10.1111/J.1750-3639.1996.Tb00876.X  0.541
1996 Wang R, Sweeney D, Gandy SE, Sisodia SS. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. The Journal of Biological Chemistry. 271: 31894-902. PMID 8943233 DOI: 10.1074/jbc.271.50.31894  0.416
1996 Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9  0.508
1996 Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, ... ... Sisodia SS, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5  0.608
1996 Lee MK, Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic models of neurodegenerative diseases. Current Opinion in Neurobiology. 6: 651-60. PMID 8937830 DOI: 10.1016/S0959-4388(96)80099-7  0.55
1996 Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7513-25. PMID 8922407 DOI: 10.1523/Jneurosci.16-23-07513.1996  0.542
1996 Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM. cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Human Molecular Genetics. 5: 1589-98. PMID 8894693 DOI: 10.1093/Hmg/5.10.1589  0.36
1996 Price DL, Koliatsos VE, Wong PC, Pardo CA, Borchelt DR, Lee MK, Cleveland DW, Griffin JW, Hoffman PN, Cork LC, Sisodia SS. Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Foundation Symposium. 196: 3-13; discussion 13-. PMID 8866125  0.621
1996 Crain BJ, Hu W, Sze CI, Slunt HH, Koo EH, Price DL, Thinakaran G, Sisodia SS. Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain. The American Journal of Pathology. 149: 1087-95. PMID 8863657  0.511
1996 Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL. Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology. 47: S54-61; discussion S. PMID 8858052 DOI: 10.1212/Wnl.47.4_Suppl_2.54S  0.651
1996 Borchelt DR, Sisodia SS. Loss of functional prion protein: a role in prion disorders? Chemistry & Biology. 3: 619-21. PMID 8807894 DOI: 10.1016/S1074-5521(96)90128-3  0.32
1996 Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408  0.498
1996 Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, ... ... Sisodia SS, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17: 181-90. PMID 8755489 DOI: 10.1016/S0896-6273(00)80291-3  0.558
1996 Sisodia SS, Thinakaran G, Slunt HH, Kitt CA, Von Koch CS, Reed RR, Zheng H, Price DL. Studies on the metabolism and biological function of APLP2. Annals of the New York Academy of Sciences. 777: 77-81. PMID 8624130 DOI: 10.1111/J.1749-6632.1996.Tb34404.X  0.552
1996 Zheng H, Jiang M, Trumbauer ME, Hopkins R, Sirinathsinghji DJ, Stevens KA, Conner MW, Slunt HH, Sisodia SS, Chen HY, Van der Ploeg LH. Mice deficient for the amyloid precursor protein gene. Annals of the New York Academy of Sciences. 777: 421-6. PMID 8624124 DOI: 10.1111/J.1749-6632.1996.Tb34456.X  0.434
1996 Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. The Journal of Biological Chemistry. 271: 9390-7. PMID 8621605 DOI: 10.1074/Jbc.271.16.9390  0.439
1996 Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Sisodia SS, Fukuchi K, Deeb SS, Disteche CM, Martin GM. 786 Investigation of FE65 and its potential role in the etiology of Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80788-3  0.316
1996 Price D, Borchelt D, Lee M, Wong P, Martin L, Sisodia S. 631 Neurodegenerative Diseases and Model Systems Neurobiology of Aging. 17: S157. DOI: 10.1016/S0197-4580(96)80633-6  0.463
1996 Gouras G, Makimura H, Sweeney D, Jovanovic J, Smith J, Sisodia S, Greengard P, Relkin N, Gandy S, Kaplitt M. 444 Expression of Alzheimer's disease associated genes in vitro and in vivo using viral vectors Neurobiology of Aging. 17: S111. DOI: 10.1016/S0197-4580(96)80446-5  0.368
1996 Thinakaran G, Doan A, Lee M, Slunt H, Savage M, Greenberg B, Wang R, Price D, Sisodia S. 443 Characterization of presenilin 1 (PS1) with mutations linked to familial Alzheimer's disease: Metabolism, topology and influence on Aβ generation Neurobiology of Aging. 17: S110. DOI: 10.1016/S0197-4580(96)80445-3  0.54
1996 Walters J, Hung A, Thinakaran G, Sisodia S, Selkoe D, Haassl C. 388 Phosphorylation of ß-amyloid precursor protein at two distinct cellular locations Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80390-3  0.364
1996 Xu H, Sweeney D, Wang R, Sisodia S, Grecngard P, Gandy S. 323 Regulation of Alzheimer β-amyloid protein precursor metabolism in cell-free systems Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80325-3  0.347
1996 Lee M, Slunt H, Thinakaran G, Price D, Sisodia S. 224 Expression of presenilin 1 and 2 in human and mouse tissues Neurobiology of Aging. 17: S56. DOI: 10.1016/S0197-4580(96)80226-0  0.436
1996 Sisodia S, Thinakaran G, Teplow D, Siman R, Savage M, Greenberg B, Lamb B, Wang R, Price D, Borchelt D. 173 Cellular sites of APP processing and all production Neurobiology of Aging. 17: S44. DOI: 10.1016/S0197-4580(96)80175-8  0.43
1996 Wong PC, Borchelt DR, Lee MK, Pardo CA, Sisodia SS, Cleveland DW, Koliatsos VE, Price DL. Transgenic and gene-targeting approaches to model disorders of motor neurons Seminars in Neuroscience. 8: 163-169. DOI: 10.1006/Smns.1996.0021  0.529
1995 Sisodia SS, Price DL. Role of the beta-amyloid protein in Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 366-70. PMID 7896005 DOI: 10.1096/Fasebj.9.5.7896005  0.56
1995 Lai A, Sisodia SS, Trowbridge IS. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. The Journal of Biological Chemistry. 270: 3565-73. PMID 7876092 DOI: 10.1074/Jbc.270.8.3565  0.405
1995 Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 954-8. PMID 7862672 DOI: 10.1073/Pnas.92.4.954  0.607
1995 Borchelt DR, Guarnieri M, Wong PC, Lee MK, Slunt HS, Xu ZS, Sisodia SS, Price DL, Cleveland DW. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. The Journal of Biological Chemistry. 270: 3234-8. PMID 7852409 DOI: 10.1074/Jbc.270.7.3234  0.61
1995 Lo AC, Thinakaran G, Slunt HH, Sisodia SS. Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain. The Journal of Biological Chemistry. 270: 12641-5. PMID 7759513 DOI: 10.1074/Jbc.270.21.12641  0.442
1995 Zhao B, Sisodia SS, Kusiak JW. Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells. Journal of Neuroscience Research. 40: 261-8. PMID 7745619 DOI: 10.1002/jnr.490400215  0.461
1995 Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL. Cellular and molecular biology of Alzheimer's disease and animal models. Neuroimaging Clinics of North America. 5: 59-68. PMID 7743085  0.501
1995 Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 3024-8. PMID 7708768 DOI: 10.1073/Pnas.92.7.3024  0.325
1995 Thinakaran G, Slunt HH, Sisodia SS. Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2. The Journal of Biological Chemistry. 270: 16522-5. PMID 7622456 DOI: 10.1074/Jbc.270.28.16522  0.459
1995 Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14: 1105-16. PMID 7605627 DOI: 10.1016/0896-6273(95)90259-7  0.656
1995 von Koch CS, Lahiri DK, Mammen AL, Copeland NG, Gilbert DJ, Jenkins NA, Sisodia S. The mouse APLP2 gene. Chromosomal localization and promoter characterization. The Journal of Biological Chemistry. 270: 25475-80. PMID 7592716 DOI: 10.1074/jbc.270.43.25475  0.342
1995 Price DL, Sisodia SS, Gandy SE. Amyloid beta amyloidosis in Alzheimer's disease. Current Opinion in Neurology. 8: 268-74. PMID 7582041 DOI: 10.1097/00019052-199508000-00004  0.585
1995 Reeves RH, Irving NG, Moran TH, Wohn A, Kitt C, Sisodia SS, Schmidt C, Bronson RT, Davisson MT. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genetics. 11: 177-84. PMID 7550346 DOI: 10.1038/ng1095-177  0.32
1994 Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS. Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). The Journal of Biological Chemistry. 269: 2637-44. PMID 8300594  0.33
1994 Price DL, Sisodia SS. Cellular and molecular biology of Alzheimer's disease and animal models. Annual Review of Medicine. 45: 435-46. PMID 8198393 DOI: 10.1146/annurev.med.45.1.435  0.592
1994 Thinakaran G, Sisodia SS. Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site. The Journal of Biological Chemistry. 269: 22099-104. PMID 8071334  0.339
1994 Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 8292-6. PMID 8058797 DOI: 10.1073/Pnas.91.17.8292  0.6
1994 Van Nostrand WE, Schmaier AH, Neiditch BR, Siegel RS, Raschke WC, Sisodia SS, Wagner SL. Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2. Biochimica Et Biophysica Acta. 1209: 165-70. PMID 7811686 DOI: 10.1016/0167-4838(94)90180-5  0.323
1994 Sisodia SS. Cellular and molecular genetic approaches in Alzheimer's disease. Neurobiology of Aging. 15: S135-7. PMID 7700438 DOI: 10.1016/0197-4580(94)90191-0  0.33
1994 Borchelt DR, Koliatsos VE, Guarnieri M, Pardo CA, Sisodia SS, Price DL. Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems. The Journal of Biological Chemistry. 269: 14711-4. PMID 7514179  0.419
1994 Koch CSv, Sisodia SS. Characterization of the promoter of the mouse amyloid precursor protein homologue, APLP2 Neurobiology of Aging. 15. DOI: 10.1016/0197-4580(94)92807-X  0.409
1994 Price DL, Sisodia SS, Martin LJ, Walker LC, Koliatsos VE. Animal models of age-associated cognitive impairment of Alzheimer's disease Journal of the Neurological Sciences. 127: 7. DOI: 10.1016/0022-510X(94)90121-X  0.472
1993 Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 3136-42. PMID 8331390  0.527
1993 da Cruz e Silva OA, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P. Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 57: 873-7. PMID 8309547 DOI: 10.1016/0306-4522(93)90031-A  0.4
1993 Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nature Genetics. 5: 95-100. PMID 8220435 DOI: 10.1038/Ng0993-95  0.448
1993 Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nature Genetics. 5: 22-30. PMID 8220418 DOI: 10.1038/Ng0993-22  0.586
1993 Price DL, Borchelt DR, Sisodia SS. Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses. Proceedings of the National Academy of Sciences of the United States of America. 90: 6381-4. PMID 8101988 DOI: 10.1073/Pnas.90.14.6381  0.556
1993 Sisodia S, Koo E, Hoffman P, Perry G, Price D. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system The Journal of Neuroscience. 13: 3136-3142. DOI: 10.1523/JNEUROSCI.13-07-03136.1993  0.578
1993 Price DL, Borchelt DR, Sisodia SS. Corrections: Alzheimer Disease and the Prion Disorders Amyloid β- Protein Amyloidoses Proceedings of the National Academy of Sciences of the United States of America. 90: 9233. DOI: 10.1073/Pnas.90.19.9233D  0.521
1993 Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Erratum: Corrigendum: Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice Nature Genetics. 5: 312-312. DOI: 10.1038/Ng1193-312D  0.538
1992 Sisodia SS. Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proceedings of the National Academy of Sciences of the United States of America. 89: 6075-9. PMID 1631093 DOI: 10.1073/Pnas.89.13.6075  0.405
1992 Price DL, Martin LJ, Clatterbuck RE, Koliatsos VE, Sisodia SS, Walker LC, Cork LC. Neuronal degeneration in human diseases and animal models. Journal of Neurobiology. 23: 1277-94. PMID 1469388 DOI: 10.1002/Neu.480230916  0.491
1992 Price DL, Borchelt DR, Walker LC, Sisodia SS. Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease. Neurobiology of Aging. 13: 623-5. PMID 1461354 DOI: 10.1016/0197-4580(92)90069-A  0.525
1992 Sisodia SS, Price DL. Amyloidogenesis in Alzheimer's disease: basic biology and animal models. Current Opinion in Neurobiology. 2: 648-52. PMID 1422121 DOI: 10.1016/0959-4388(92)90033-H  0.574
1992 Price DL, Walker LC, Martin LJ, Sisodia SS. Amyloidosis in aging and Alzheimer's disease. The American Journal of Pathology. 141: 767-72. PMID 1415474  0.434
1992 Price DL, Martin LJ, Sisodia SS, Walker LC, Cork LC. Alzheimer's disease-type brain abnormalities in animal models. Progress in Clinical and Biological Research. 379: 271-87. PMID 1409750  0.45
1992 Sisodia SS. Secretion of the beta-amyloid precursor protein. Annals of the New York Academy of Sciences. 674: 53-7. PMID 1288370 DOI: 10.1111/J.1749-6632.1992.Tb27476.X  0.369
1992 Levey AI, Sisodia SS, Price DL. Advances in the molecular neurobiology of Alzheimerʼs disease Current Opinion in Psychiatry. 5: 98-102. DOI: 10.1097/00001504-199202000-00022  0.456
1992 Wang R, Cotter RJ, Meschia JF, Sisodia SS. Determination of the Cleavage Site of the Amyloid Precursor Protein by Plasma Desorption Mass Spectrometry Techniques in Protein Chemistry. 505-513. DOI: 10.1016/B978-0-12-058756-8.50056-0  0.334
1992 Price D, Sisodia S, Martin L, Walker L, Koliatsos V. Models for the study of amyloidogenesis Neurochemistry International. 21: S11. DOI: 10.1016/0197-0186(92)91756-M  0.315
1991 Price DL, Koliatsos VE, Sisodia SS, Koo EH, Martin LJ, Walker LC, Appelgate MD, Cork LC. Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models. Clinical Neuropharmacology. 14: S9-14. PMID 1913711 DOI: 10.1097/00002826-199114001-00003  0.563
1991 Wang R, Meschia JF, Cotter RJ, Sisodia SS. Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells. The Journal of Biological Chemistry. 266: 16960-4. PMID 1909332  0.32
1991 Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. Amyloid precursor protein in aged nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 88: 1461-5. PMID 1899927 DOI: 10.1073/Pnas.88.4.1461  0.545
1991 Goedert M, Sisodia SS, Price DL. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Current Opinion in Neurobiology. 1: 441-7. PMID 1821689 DOI: 10.1016/0959-4388(91)90067-H  0.572
1991 Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Annals of the New York Academy of Sciences. 640: 161-5. PMID 1776735 DOI: 10.1111/J.1749-6632.1991.Tb00209.X  0.531
1991 Price DL, Martin LJ, Sisodia SS, Wagster MV, Koo EH, Walker LC, Koliatsos VE, Cork LC. Aged non-human primates: an animal model of age-associated neurodegenerative disease. Brain Pathology (Zurich, Switzerland). 1: 287-96. PMID 1688300 DOI: 10.1111/J.1750-3639.1991.Tb00672.X  0.49
1990 Price DL, Sisodia SS, Koo EH, Muma NA, Kitt CA, Walker LC, Martin LJ, Troncoso JC, Griffin JW, Hoffman PN. Neuronal disorders: studies of animal models and human diseases. Toxicologic Pathology. 18: 128-37. PMID 2195633 DOI: 10.1177/019262339001800118  0.51
1990 Koo EH, Sisodia SS, Cork LC, Unterbeck A, Bayney RM, Price DL. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron. 4: 97-104. PMID 2106906 DOI: 10.1016/0896-6273(90)90446-M  0.577
1990 Price DL, Koo EH, Sisodia SS, Martin LJ, Koliatsos VE, Muma NA, Walker LC, Cork LC. Neuronal responses to injury and aging: lessons from animal models. Progress in Brain Research. 86: 297-308. PMID 2087560 DOI: 10.1016/S0079-6123(08)63186-6  0.554
1990 Sisodia SS, Gay DA, Cleveland DW. In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. The New Biologist. 2: 66-76. PMID 2078553  0.456
1990 Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (New York, N.Y.). 248: 492-5. PMID 1691865 DOI: 10.1126/Science.1691865  0.544
1990 Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Fischer P, Masters CL, Price DL. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America. 87: 1561-5. PMID 1689489 DOI: 10.1073/Pnas.87.4.1561  0.583
1990 Sisodia SS, Meschia JF, Koo EH, Price DL. CHARACTERIZATION OF THE CARBOXY TERMINUS OF THE SECRETED FORM OF APP IN CULTURED CELLS Journal of Neuropathology and Experimental Neurology. 49: 333. DOI: 10.1097/00005072-199005000-00221  0.378
1989 Gay DA, Sisodia SS, Cleveland DW. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proceedings of the National Academy of Sciences of the United States of America. 86: 5763-7. PMID 2762294 DOI: 10.1073/Pnas.86.15.5763  0.498
1989 Price DL, Koo EH, Sisodia SS, Walker LC, Martin LJ, Cork LC. Cellular/molecular biological studies of brain abnormalities in Alzheimer's disease and animal models Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 1: 13-13. DOI: 10.1007/BF02312194  0.45
1987 Sisodia SS, Sollner-Webb B, Cleveland DW. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Molecular and Cellular Biology. 7: 3602-12. PMID 3683396 DOI: 10.1128/mcb.7.10.3602-3612.1987  0.431
1987 Gabriel A, Sisodia SS, Cleveland DW. Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. The Journal of Biological Chemistry. 262: 16192-9. PMID 3680249  0.397
1987 Sisodia SS, Cleveland DW, Sollner-Webb B. A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Research. 15: 1995-2011. PMID 3031584 DOI: 10.1093/nar/15.5.1995  0.442
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