Susumu Tonegawa - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Learning and Memory
Website:
http://web.mit.edu/bcs/people/tonegawa.shtml

235 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Roy DS, Park YG, Kim ME, Zhang Y, Ogawa SK, DiNapoli N, Gu X, Cho JH, Choi H, Kamentsky L, Martin J, Mosto O, Aida T, Chung K, Tonegawa S. Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions. Nature Communications. 13: 1799. PMID 35379803 DOI: 10.1038/s41467-022-29384-4  0.689
2021 MacDonald CJ, Tonegawa S. Reply to Lehr and Stöber: What's in a name? On the distinction between temporal coding and internally driven activity. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34518215 DOI: 10.1073/pnas.2112026118  0.509
2021 MacDonald CJ, Tonegawa S. Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33431691 DOI: 10.1073/pnas.2020698118  0.635
2020 Bari A, Xu S, Pignatelli M, Takeuchi D, Feng J, Li Y, Tonegawa S. Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 33139568 DOI: 10.1073/pnas.2015635117  0.688
2020 Lak A, Hueske E, Hirokawa J, Masset P, Ott T, Urai AE, Donner TH, Carandini M, Tonegawa S, Uchida N, Kepecs A. Confidence-guided updating of choice bias during perceptual decisions is a widespread behavioral phenomenon. Elife. 9. PMID 32286227 DOI: 10.7554/Elife.49834  0.765
2020 Sun C, Yang W, Martin J, Tonegawa S. Hippocampal neurons represent events as transferable units of experience. Nature Neuroscience. PMID 32251386 DOI: 10.1038/s41593-020-0614-x  0.333
2020 Zhang X, Kim J, Tonegawa S. Amygdala Reward Neurons Form and Store Fear Extinction Memory. Neuron. PMID 31952856 DOI: 10.1016/J.Neuron.2019.12.025  0.55
2020 Josselyn SA, Tonegawa S. Memory engrams: Recalling the past and imagining the future. Science (New York, N.Y.). 367. PMID 31896692 DOI: 10.1126/Science.Aaw4325  0.656
2018 Pignatelli M, Ryan TJ, Roy DS, Lovett C, Smith LM, Muralidhar S, Tonegawa S. Engram Cell Excitability State Determines the Efficacy of Memory Retrieval. Neuron. PMID 30551997 DOI: 10.1016/J.Neuron.2018.11.029  0.815
2018 Tonegawa S, Morrissey MD, Kitamura T. The role of engram cells in the systems consolidation of memory. Nature Reviews. Neuroscience. PMID 29970909 DOI: 10.1038/S41583-018-0031-2  0.803
2017 Wagatsuma A, Okuyama T, Sun C, Smith LM, Abe K, Tonegawa S. Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279390 DOI: 10.1073/pnas.1714082115  0.609
2017 Roy DS, Muralidhar S, Smith LM, Tonegawa S. Silent memory engrams as the basis for retrograde amnesia. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078397 DOI: 10.1073/Pnas.1714248114  0.797
2017 Xu S, Das G, Hueske E, Tonegawa S. Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off. Current Biology : Cb. PMID 28988863 DOI: 10.1016/j.cub.2017.09.008  0.771
2017 Yamamoto J, Tonegawa S. Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay. Neuron. 96: 217-227.e4. PMID 28957670 DOI: 10.1016/J.Neuron.2017.09.017  0.529
2017 Roy DS, Okuyama T, Tonegawa S. Tagging activated neurons with light. Nature Biotechnology. 35: 827-828. PMID 28898205 DOI: 10.1038/Nbt.3954  0.698
2017 Roy DS, Kitamura T, Okuyama T, Ogawa SK, Sun C, Obata Y, Yoshiki A, Tonegawa S. Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories. Cell. PMID 28823555 DOI: 10.1016/J.Cell.2017.07.013  0.821
2017 Kitamura T, Ogawa SK, Roy DS, Okuyama T, Morrissey MD, Smith LM, Redondo RL, Tonegawa S. Engrams and circuits crucial for systems consolidation of a memory. Science (New York, N.Y.). 356: 73-78. PMID 28386011 DOI: 10.1126/Science.Aam6808  0.819
2017 Kim J, Zhang X, Muralidhar S, LeBlanc SA, Tonegawa S. Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors. Neuron. 93: 1464-1479.e5. PMID 28334609 DOI: 10.1016/J.Neuron.2017.02.034  0.66
2017 Roy DS, Tonegawa S. Manipulating memory in space and time Current Opinion in Behavioral Sciences. 17: 1-6. DOI: 10.1016/J.Cobeha.2017.05.020  0.71
2016 Kim J, Pignatelli M, Xu S, Itohara S, Tonegawa S. Antagonistic negative and positive neurons of the basolateral amygdala. Nature Neuroscience. PMID 27749826 DOI: 10.1038/nn.4414  0.717
2016 Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science (New York, N.Y.). 353: 1536-1541. PMID 27708103 DOI: 10.1126/Science.Aaf7003  0.816
2016 Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, et al. What is memory? The present state of the engram. Bmc Biology. 14: 40. PMID 27197636 DOI: 10.1186/S12915-016-0261-6  0.655
2016 Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S. Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease. Nature. PMID 26982728 DOI: 10.1038/Nature17172  0.765
2016 Ryan TJ, Tonegawa S. Rehebbilitating Memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 1437. PMID 26964904 DOI: 10.1038/Npp.2016.4  0.55
2016 Ryan TJ, Tonegawa S. Rehebbilitating Memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 370-1. PMID 26657949 DOI: 10.1038/Npp.2015.264  0.571
2015 Kitamura T, Sun C, Martin J, Kitch LJ, Schnitzer MJ, Tonegawa S. Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. Neuron. 87: 1317-31. PMID 26402611 DOI: 10.1016/J.Neuron.2015.08.036  0.693
2015 Tonegawa S, Liu X, Ramirez S, Redondo R. Memory Engram Cells Have Come of Age. Neuron. 87: 918-31. PMID 26335640 DOI: 10.1016/J.Neuron.2015.08.002  0.756
2015 Kitamura T, Macdonald CJ, Tonegawa S. Entorhinal-hippocampal neuronal circuits bridge temporally discontiguous events. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 438-43. PMID 26286654 DOI: 10.1101/Lm.038687.115  0.759
2015 Tonegawa S, Pignatelli M, Roy DS, Ryan TJ. Memory engram storage and retrieval. Current Opinion in Neurobiology. 35: 101-109. PMID 26280931 DOI: 10.1016/J.Conb.2015.07.009  0.756
2015 Sariñana J, Tonegawa S. Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory. Hippocampus. PMID 26174222 DOI: 10.1002/hipo.22492  0.803
2015 Sun C, Kitamura T, Yamamoto J, Martin J, Pignatelli M, Kitch LJ, Schnitzer MJ, Tonegawa S. Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9466-71. PMID 26170279 DOI: 10.1073/Pnas.1511668112  0.687
2015 Bittner KC, Grienberger C, Vaidya SP, Milstein AD, Macklin JJ, Suh J, Tonegawa S, Magee JC. Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons. Nature Neuroscience. 18: 1133-42. PMID 26167906 DOI: 10.1038/Nn.4062  0.632
2015 Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 522: 335-9. PMID 26085274 DOI: 10.1038/Nature14514  0.797
2015 Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S. Memory. Engram cells retain memory under retrograde amnesia. Science (New York, N.Y.). 348: 1007-13. PMID 26023136 DOI: 10.1126/Science.Aaa5542  0.767
2015 Sun C, Kitamura T, Yamamoto J, Martin J, Pignatelli M, Kitch LJ, Schnitzer MJ, Tonegawa S. Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells Proceedings of the National Academy of Sciences of the United States of America. 112: 9466-9471. DOI: 10.1073/pnas.1511668112  0.62
2015 Tonegawa S, Pignatelli M, Roy DS, Ryan TJ. Memory engram storage and retrieval Current Opinion in Neurobiology. 35: 101-109. DOI: 10.1016/j.conb.2015.07.009  0.734
2014 Liu X, Ramirez S, Redondo RL, Tonegawa S. Identification and Manipulation of Memory Engram Cells. Cold Spring Harbor Symposia On Quantitative Biology. 79: 59-65. PMID 25637263 DOI: 10.1101/Sqb.2014.79.024901  0.754
2014 Redondo RL, Kim J, Arons AL, Ramirez S, Liu X, Tonegawa S. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature. 513: 426-30. PMID 25162525 DOI: 10.1038/Nature13725  0.773
2014 Yi F, Ball J, Stoll KE, Satpute VC, Mitchell SM, Pauli JL, Holloway BB, Johnston AD, Nathanson NM, Deisseroth K, Gerber DJ, Tonegawa S, Lawrence JJ. Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition. The Journal of Physiology. 592: 3463-94. PMID 24879872 DOI: 10.1113/Jphysiol.2014.275453  0.424
2014 Sariñana J, Kitamura T, Künzler P, Sultzman L, Tonegawa S. Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory. Proceedings of the National Academy of Sciences of the United States of America. 111: 8245-50. PMID 24843151 DOI: 10.1073/Pnas.1407395111  0.798
2014 Yamamoto J, Suh J, Takeuchi D, Tonegawa S. Successful execution of working memory linked to synchronized high-frequency gamma oscillations. Cell. 157: 845-57. PMID 24768692 DOI: 10.1016/J.Cell.2014.04.009  0.725
2014 Kitamura T, Pignatelli M, Suh J, Kohara K, Yoshiki A, Abe K, Tonegawa S. Island cells control temporal association memory. Science (New York, N.Y.). 343: 896-901. PMID 24457215 DOI: 10.1126/Science.1244634  0.818
2014 Dragoi G, Tonegawa S. Selection of preconfigured cell assemblies for representation of novel spatial experiences. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20120522. PMID 24366134 DOI: 10.1098/Rstb.2012.0522  0.627
2014 Kohara K, Pignatelli M, Rivest AJ, Jung HY, Kitamura T, Suh J, Frank D, Kajikawa K, Mise N, Obata Y, Wickersham IR, Tonegawa S. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nature Neuroscience. 17: 269-79. PMID 24336151 DOI: 10.1038/Nn.3614  0.793
2014 Liu X, Ramirez S, Tonegawa S. Inception of a false memory by optogenetic manipulation of a hippocampal memory engram. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130142. PMID 24298144 DOI: 10.1098/Rstb.2013.0142  0.67
2013 Ramirez S, Tonegawa S, Liu X. Identification and optogenetic manipulation of memory engrams in the hippocampus. Frontiers in Behavioral Neuroscience. 7: 226. PMID 24478647 DOI: 10.3389/Fnbeh.2013.00226  0.664
2013 Dragoi G, Tonegawa S. Development of schemas revealed by prior experience and NMDA receptor knock-out. Elife. 2: e01326. PMID 24327561 DOI: 10.7554/Elife.01326  0.681
2013 Suh J, Foster DJ, Davoudi H, Wilson MA, Tonegawa S. Impaired hippocampal ripple-associated replay in a mouse model of schizophrenia. Neuron. 80: 484-93. PMID 24139046 DOI: 10.1016/j.neuron.2013.09.014  0.739
2013 Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, Ryan TJ, Tonegawa S. Creating a false memory in the hippocampus. Science (New York, N.Y.). 341: 387-91. PMID 23888038 DOI: 10.1126/Science.1239073  0.828
2013 Dragoi G, Tonegawa S. Distinct preplay of multiple novel spatial experiences in the rat. Proceedings of the National Academy of Sciences of the United States of America. 110: 9100-5. PMID 23671088 DOI: 10.1073/Pnas.1306031110  0.634
2013 Dolan BM, Duron SG, Campbell DA, Vollrath B, Shankaranarayana Rao BS, Ko HY, Lin GG, Govindarajan A, Choi SY, Tonegawa S. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proceedings of the National Academy of Sciences of the United States of America. 110: 5671-6. PMID 23509247 DOI: 10.1073/Pnas.1219383110  0.775
2013 Dragoi G, Tonegawa S. Author response: Development of schemas revealed by prior experience and NMDA receptor knock-out Elife. DOI: 10.7554/Elife.01326.017  0.602
2012 Lopez CM, Pelkey KA, Chittajallu R, Nakashiba T, Tóth K, Tonegawa S, McBain CJ. Competition from newborn granule cells does not drive axonal retraction of silenced old granule cells in the adult hippocampus. Frontiers in Neural Circuits. 6: 85. PMID 23162435 DOI: 10.3389/fncir.2012.00085  0.351
2012 Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature. 484: 381-5. PMID 22441246 DOI: 10.1038/Nature11028  0.822
2012 Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, Sauvage MM. NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 164-9. PMID 22419815 DOI: 10.1101/Lm.025254.111  0.825
2012 Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell. 149: 188-201. PMID 22365813 DOI: 10.1016/J.Cell.2012.01.046  0.786
2011 Suh J, Rivest AJ, Nakashiba T, Tominaga T, Tonegawa S. Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science (New York, N.Y.). 334: 1415-20. PMID 22052975 DOI: 10.1126/Science.1210125  0.813
2011 Govindarajan A, Israely I, Huang SY, Tonegawa S. The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP. Neuron. 69: 132-46. PMID 21220104 DOI: 10.1016/j.neuron.2010.12.008  0.754
2011 Dragoi G, Tonegawa S. Preplay of future place cell sequences by hippocampal cellular assemblies. Nature. 469: 397-401. PMID 21179088 DOI: 10.1038/Nature09633  0.634
2011 Tonegawa S. How does the hippocampus handle episodic memories Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.1827  0.415
2010 Torborg CL, Nakashiba T, Tonegawa S, McBain CJ. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15628-37. PMID 21084618 DOI: 10.1523/JNEUROSCI.3099-10.2010  0.36
2010 Wiltgen BJ, Royle GA, Gray EE, Abdipranoto A, Thangthaeng N, Jacobs N, Saab F, Tonegawa S, Heinemann SF, O'Dell TJ, Fanselow MS, Vissel B. A role for calcium-permeable AMPA receptors in synaptic plasticity and learning. Plos One. 5. PMID 20927382 DOI: 10.1371/Journal.Pone.0012818  0.754
2010 Liu X, Tonegawa S. Optogenetics 3.0. Cell. 141: 22-4. PMID 20371341 DOI: 10.1016/j.cell.2010.03.019  0.381
2010 Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. Enhancement of learning and memory by elevating brain magnesium. Neuron. 65: 165-77. PMID 20152124 DOI: 10.1016/J.Neuron.2009.12.026  0.817
2010 Kamsler A, McHugh TJ, Gerber D, Huang SY, Tonegawa S. Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 107: 1618-23. PMID 20080609 DOI: 10.1073/pnas.0912540107  0.799
2010 Hashimoto K, Serafin A, Tonegawa S, Katsumata R, Okazaki R, Saito T, Fukazawa H, Kohori Y, Kihou K, Lee CH, Iyo A, Eisaki H, Ikeda H, Matsuda Y, Carrington A, et al. Evidence for superconducting gap nodes in the zone-centered hole bands of KFe2As2 from magnetic penetration-depth measurements Physical Review B - Condensed Matter and Materials Physics. 82. DOI: 10.1103/PhysRevB.82.014526  0.388
2010 Kasahara S, Shibauchi T, Hashimoto K, Ikada K, Tonegawa S, Okazaki R, Shishido H, Ikeda H, Takeya H, Hirata K, Terashima T, Matsuda Y. Evolution from non-Fermi- to Fermi-liquid transport via isovalent doping in BaFe2(As1-xPx)2 superconductors Physical Review B - Condensed Matter and Materials Physics. 81. DOI: 10.1103/Physrevb.81.184519  0.41
2010 Kasahara S, Hashimoto K, Okazaki R, Shishido H, Yamashita M, Ikada K, Tonegawa S, Nakata N, Sensyu Y, Takeya H, Hirata K, Shibauchi T, Terashima T, Matsuda Y. Superconductivity induced by isovalent doping in single crystals of BaFe2(As1-xPx)2 Physica C: Superconductivity and Its Applications. 470: S462-S463. DOI: 10.1016/J.Physc.2009.10.137  0.399
2009 Jinde S, Belforte JE, Yamamoto J, Wilson MA, Tonegawa S, Nakazawa K. Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. The European Journal of Neuroscience. 30: 1036-55. PMID 19735292 DOI: 10.1111/J.1460-9568.2009.06896.X  0.794
2009 McHugh TJ, Tonegawa S. CA3 NMDA receptors are required for the rapid formation of a salient contextual representation. Hippocampus. 19: 1153-8. PMID 19650121 DOI: 10.1002/hipo.20684  0.744
2009 Nakashiba T, Buhl DL, McHugh TJ, Tonegawa S. Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory. Neuron. 62: 781-7. PMID 19555647 DOI: 10.1016/j.neuron.2009.05.013  0.828
2009 Hashimoto K, Shibauchi T, Kasahara S, Ikada K, Tonegawa S, Kato T, Okazaki R, van der Beek CJ, Konczykowski M, Takeya H, Hirata K, Terashima T, Matsuda Y. Microwave surface-impedance measurements of the magnetic penetration depth in single crystal Ba1-xKxFe2As2 superconductors: evidence for a disorder-dependent superfluid density. Physical Review Letters. 102: 207001. PMID 19519062 DOI: 10.1103/Physrevlett.102.207001  0.399
2009 McHugh T, Nakashiba T, Buhl DL, Young JZ, Tonegawa S. The role of CA3 transmission in the acquisition and consolidation of spatial memory Neuroscience Research. 65: S31. DOI: 10.1016/j.neures.2009.09.1674  0.813
2008 Nakashiba T, Young JZ, McHugh TJ, Buhl DL, Tonegawa S. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science (New York, N.Y.). 319: 1260-4. PMID 18218862 DOI: 10.1126/science.1151120  0.812
2008 Tonegawa S, McHugh TJ. The ins and outs of hippocampal circuits. Neuron. 57: 175-7. PMID 18215616 DOI: 10.1016/j.neuron.2008.01.005  0.755
2008 Gharami K, Xie Y, An JJ, Tonegawa S, Xu B. Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice. Journal of Neurochemistry. 105: 369-79. PMID 18086127 DOI: 10.1111/J.1471-4159.2007.05137.X  0.319
2008 Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cerebral Cortex (New York, N.Y. : 1991). 18: 53-66. PMID 17478416 DOI: 10.1093/Cercor/Bhm031  0.471
2008 Nakazawa K, Wilson MA, Tonegawa S. On crucial roles of hippocampal NMDA receptors in acquisition and recall of associative memory Topics in Integrative Neuroscience: From Cells to Cognition. 326-356. DOI: 10.1017/CBO9780511541681.017  0.737
2007 Kent K, Hess K, Tonegawa S, Small SA. CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Hippocampus. 17: 1003-11. PMID 17607765 DOI: 10.1002/Hipo.20332  0.386
2007 Hayashi ML, Rao BS, Seo JS, Choi HS, Dolan BM, Choi SY, Chattarji S, Tonegawa S. Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 11489-94. PMID 17592139 DOI: 10.1073/pnas.0705003104  0.703
2007 McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (New York, N.Y.). 317: 94-9. PMID 17556551 DOI: 10.1126/Science.1140263  0.811
2007 McHugh TJ, Tonegawa S. Spatial exploration is required for the formation of contextual fear memory. Behavioral Neuroscience. 121: 335-9. PMID 17469922 DOI: 10.1037/0735-7044.121.2.335  0.745
2007 Kishimoto Y, Nakazawa K, Tonegawa S, Kano M, Kirino Y. 1P203 Hippocampal CA3 NMDA receptors network is crucial for adaptive timing and retrieval of trace conditioning(Chemoreception, neuron and sensory system, neural network, and brain computing,Oral Presentations) Seibutsu Butsuri. 47: S74. DOI: 10.2142/Biophys.47.S74_2  0.785
2006 Govindarajan A, Rao BS, Nair D, Trinh M, Mawjee N, Tonegawa S, Chattarji S. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 103: 13208-13. PMID 16924103 DOI: 10.1073/pnas.0605180103  0.781
2006 Wang KH, Majewska A, Schummers J, Farley B, Hu C, Sur M, Tonegawa S. In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. Cell. 126: 389-402. PMID 16873068 DOI: 10.1016/J.Cell.2006.06.038  0.512
2006 Govindarajan A, Kelleher RJ, Tonegawa S. A clustered plasticity model of long-term memory engrams. Nature Reviews. Neuroscience. 7: 575-83. PMID 16791146 DOI: 10.1038/nrn1937  0.801
2006 Rondi-Reig L, Petit GH, Tobin C, Tonegawa S, Mariani J, Berthoz A. Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4071-81. PMID 16611824 DOI: 10.1523/Jneurosci.3408-05.2006  0.811
2006 Kishimoto Y, Nakazawa K, Tonegawa S, Kirino Y, Kano M. Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1562-70. PMID 16452679 DOI: 10.1523/Jneurosci.4142-05.2006  0.812
2005 Chan GC, Tonegawa S, Storm DR. Hippocampal neurons express a calcineurin-activated adenylyl cyclase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9913-8. PMID 16251439 DOI: 10.1523/JNEUROSCI.2376-05.2005  0.39
2005 Anderson MP, Mochizuki T, Xie J, Fischler W, Manger JP, Talley EM, Scammell TE, Tonegawa S. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proceedings of the National Academy of Sciences of the United States of America. 102: 1743-8. PMID 15677322 DOI: 10.1073/Pnas.0409644102  0.541
2004 Kelleher RJ, Govindarajan A, Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron. 44: 59-73. PMID 15450160 DOI: 10.1016/J.Neuron.2004.09.013  0.795
2004 Newton JR, Ellsworth C, Miyakawa T, Tonegawa S, Sur M. Acceleration of visually cued conditioned fear through the auditory pathway. Nature Neuroscience. 7: 968-73. PMID 15322551 DOI: 10.1038/nn1306  0.465
2004 Hayashi ML, Choi SY, Rao BS, Jung HY, Lee HK, Zhang D, Chattarji S, Kirkwood A, Tonegawa S. Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice. Neuron. 42: 773-87. PMID 15182717 DOI: 10.1016/j.neuron.2004.05.003  0.819
2004 Nakazawa K, McHugh TJ, Wilson MA, Tonegawa S. NMDA receptors, place cells and hippocampal spatial memory. Nature Reviews. Neuroscience. 5: 361-72. PMID 15100719 DOI: 10.1038/nrn1385  0.835
2004 Kelleher RJ, Govindarajan A, Jung HY, Kang H, Tonegawa S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 116: 467-79. PMID 15016380 DOI: 10.1016/S0092-8674(04)00115-1  0.811
2003 Gianfranceschi L, Siciliano R, Walls J, Morales B, Kirkwood A, Huang ZJ, Tonegawa S, Maffei L. Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF. Proceedings of the National Academy of Sciences of the United States of America. 100: 12486-91. PMID 14514885 DOI: 10.1073/Pnas.1934836100  0.608
2003 Shutoh F, Katoh A, Ohki M, Itohara S, Tonegawa S, Nagao S. Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice. The European Journal of Neuroscience. 18: 134-42. PMID 12859346 DOI: 10.1046/j.1460-9568.2003.02717.x  0.535
2003 Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M, Tonegawa S. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 100: 8993-8. PMID 12851458 DOI: 10.1073/pnas.1432927100  0.428
2003 Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova TD, Zeng H, Caron MG, Tonegawa S. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 100: 8987-92. PMID 12851457 DOI: 10.1073/Pnas.1432926100  0.605
2003 Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF. NMDA receptor-dependent ocular dominance plasticity in adult visual cortex. Neuron. 38: 977-85. PMID 12818182 DOI: 10.1016/S0896-6273(03)00323-4  0.781
2003 Tonegawa S, Nakazawa K, Wilson MA. Genetic neuroscience of mammalian learning and memory. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 787-95. PMID 12740125 DOI: 10.1098/rstb.2002.1243  0.774
2003 Nakazawa K, Sun LD, Quirk MC, Rondi-Reig L, Wilson MA, Tonegawa S. Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron. 38: 305-15. PMID 12718863 DOI: 10.1016/S0896-6273(03)00165-X  0.826
2003 Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 4855-60. PMID 12676993 DOI: 10.1073/pnas.0830996100  0.367
2003 Hinds HL, Goussakov I, Nakazawa K, Tonegawa S, Bolshakov VY. Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proceedings of the National Academy of Sciences of the United States of America. 100: 4275-80. PMID 12629219 DOI: 10.1073/Pnas.0530202100  0.793
2003 Newton JR, Ellsworth C, Miyakawa T, Tonegawa S, Sur M. C-fos expression and accelerated visual cued fear conditioning in mice with visual input directed to the auditory thalamus Journal of Vision. 3: 770a. DOI: 10.1167/3.9.770  0.441
2003 Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF. Erratum Neuron. 39: 727. DOI: 10.1016/S0896-6273(03)00475-6  0.737
2002 Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Johnston D, Wilson MA, Tonegawa S. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science (New York, N.Y.). 297: 211-8. PMID 12040087 DOI: 10.1126/science.1071795  0.789
2002 Huang ZJ, Yu W, Lovett C, Tonegawa S. Cre/loxP recombination-activated neuronal markers in mouse neocortex and hippocampus. Genesis (New York, N.Y. : 2000). 32: 209-17. PMID 11892010 DOI: 10.1002/Gene.10054  0.642
2001 Arrow KJ, Axelrod J, Benacerraf B, Berg P, Bishop JM, Bloembergen N, Brown HC, Cibelli J, Cohen S, Cooper LN, Corey EJ, Cronin JW, Curl R, Dulbecco R, Fischer EH, ... ... Tonegawa S, et al. Nobel laureates' letter to President Bush. The Washington Post. A02. PMID 12462241  0.539
2001 Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S. Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell. 107: 617-29. PMID 11733061 DOI: 10.1016/S0092-8674(01)00585-2  0.831
2001 Kang H, Sun LD, Atkins CM, Soderling TR, Wilson MA, Tonegawa S. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell. 106: 771-83. PMID 11572782 DOI: 10.1016/S0092-8674(01)00497-4  0.676
2001 Rondi-Reig L, Libbey M, Eichenbaum H, Tonegawa S. CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proceedings of the National Academy of Sciences of the United States of America. 98: 3543-8. PMID 11248114 DOI: 10.1073/pnas.041620798  0.786
2000 Wang Y, Xu R, Sasaoka T, Tonegawa S, Kung MP, Sankoorikal EB. Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8305-14. PMID 11069937 DOI: 10.1523/Jneurosci.20-22-08305.2000  0.319
2000 Iwasato T, Datwani A, Wolf AM, Nishiyama H, Taguchi Y, Tonegawa S, Knöpfel T, Erzurumlu RS, Itohara S. Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature. 406: 726-31. PMID 10963597 DOI: 10.1038/35021059  0.535
2000 Huerta PT, Sun LD, Wilson MA, Tonegawa S. Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron. 25: 473-80. PMID 10719900 DOI: 10.1016/S0896-6273(00)80909-5  0.811
1999 Hanover JL, Huang ZJ, Tonegawa S, Stryker MP. Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: RC40. PMID 10559430 DOI: 10.1523/Jneurosci.19-22-J0003.1999  0.598
1999 Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 98: 739-55. PMID 10499792 DOI: 10.1016/S0092-8674(00)81509-3  0.626
1999 Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Research. Molecular Brain Research. 69: 273-80. PMID 10366748 DOI: 10.1016/S0169-328X(99)00119-9  0.311
1999 Levelt CN, de Jong YP, Mizoguchi E, O'Farrelly C, Bhan AK, Tonegawa S, Terhorst C, Simpson SJ. High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 96: 5628-33. PMID 10318935 DOI: 10.1073/pnas.96.10.5628  0.64
1999 Demas GE, Kriegsfeld LJ, Poss KD, Tonegawa S, Nelson RJ. Circadian locomotor rhythms in mice with targeted disruption of the gene for the carbon monoxide synthesizing enzyme, heme oxygenase-2 Biological Rhythm Research. 30: 282-289. DOI: 10.1076/Brhm.30.3.282.3053  0.582
1998 Hinds HL, Tonegawa S, Malinow R. CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice. Learning & Memory (Cold Spring Harbor, N.Y.). 5: 344-54. PMID 10454359 DOI: 10.1101/Lm.5.4.344  0.792
1998 Levelt CN, Mizoguchi E, Huang X, Zacks R, Bhan AK, Tonegawa S. Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide. Proceedings of the National Academy of Sciences of the United States of America. 95: 14349-54. PMID 9826703 DOI: 10.1073/pnas.95.24.14349  0.655
1998 Van de Keere F, Tonegawa S. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. The Journal of Experimental Medicine. 188: 1875-82. PMID 9815265 DOI: 10.1084/jem.188.10.1875  0.308
1998 Burnett AL, Johns DG, Kriegsfeld LJ, Klein SL, Calvin DC, Demas GE, Schramm LP, Tonegawa S, Nelson RJ, Snyder SH, Poss KD. Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nature Medicine. 4: 84-7. PMID 9427611 DOI: 10.1038/Nm0198-084  0.58
1998 Newell KL, Shen J, Berezovska O, Christie RH, Tonegawa S, Hyman BT. Neuropathological Studies In Mice Heterozygous For The Disrupted Presenilin-1 Gene Journal of Neuropathology and Experimental Neurology. 57: 512. DOI: 10.1097/00005072-199805000-00192  0.306
1997 Iwasato T, Erzurumlu RS, Huerta PT, Chen DF, Sasaoka T, Ulupinar E, Tonegawa S. NMDA receptor-dependent refinement of somatotopic maps. Neuron. 19: 1201-10. PMID 9427244 DOI: 10.1016/S0896-6273(00)80412-2  0.681
1997 Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, Snyder SH. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America. 94: 14848-53. PMID 9405702 DOI: 10.1073/Pnas.94.26.14848  0.579
1997 Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 10925-30. PMID 9380736 DOI: 10.1073/Pnas.94.20.10925  0.568
1997 Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proceedings of the National Academy of Sciences of the United States of America. 94: 10919-24. PMID 9380735 DOI: 10.1073/Pnas.94.20.10919  0.537
1997 Xu M, Koeltzow TE, Santiago GT, Moratalla R, Cooper DC, Hu XT, White NM, Graybiel AM, White FJ, Tonegawa S. Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 19: 837-48. PMID 9354330 DOI: 10.1016/S0896-6273(00)80965-4  0.664
1997 Silva AJ, Simpson EM, Takahashi JS, Lipp HP, Nakanishi S, Wehner JM, Giese KP, Tully T, Abel T, Chapman PF, Fox K, Grant S, Itohara S, Lathe R, Mayford M, ... ... Tonegawa S, et al. Mutant mice and neuroscience: Recommendations concerning genetic background Neuron. 19: 755-759. PMID 9354323 DOI: 10.1016/S0896-6273(00)80958-7  0.702
1997 Marusi? S, Tonegawa S. Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide. The Journal of Experimental Medicine. 186: 507-15. PMID 9254649 DOI: 10.1084/jem.186.4.507  0.304
1997 Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89: 629-39. PMID 9160754 DOI: 10.1016/S0092-8674(00)80244-5  0.304
1997 Pereira P, Lafaille JJ, Gerber D, Tonegawa S. The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proceedings of the National Academy of Sciences of the United States of America. 94: 5761-6. PMID 9159147 DOI: 10.1073/Pnas.94.11.5761  0.308
1997 Wilson MA, Tonegawa S. Synaptic plasticity, place cells and spatial memory: study with second generation knockouts. Trends in Neurosciences. 20: 102-6. PMID 9061862 DOI: 10.1016/S0166-2236(96)01023-5  0.679
1997 Chen C, Tonegawa S. Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annual Review of Neuroscience. 20: 157-84. PMID 9056711 DOI: 10.1146/annurev.neuro.20.1.157  0.431
1997 Kano M, Hashimoto K, Kurihara H, Watanabe M, Inoue Y, Aiba A, Tonegawa S. Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron. 18: 71-9. PMID 9010206 DOI: 10.1016/S0896-6273(01)80047-7  0.303
1997 Simpson SJ, Mellor A, Terhorst C, Tonegawa S, Levelt C. CD8α+β− intestinal intraepithelial lymphocytes in T cell receptor transgenic mice are positively selected by high affinity ligands Immunology Letters. 56: 99. DOI: 10.1016/S0165-2478(97)85392-8  0.659
1996 Goda Y, Stevens CF, Tonegawa S. Phorbol ester effects at hippocampal synapses act independently of the gamma isoform of PKC. Learning & Memory (Cold Spring Harbor, N.Y.). 3: 182-7. PMID 10456088 DOI: 10.1101/Lm.3.2-3.182  0.367
1996 Tonegawa S, Tsien JZ, McHugh TJ, Huerta P, Blum KI, Wilson MA. Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harbor Symposia On Quantitative Biology. 61: 225-38. PMID 9246451 DOI: 10.1101/Sqb.1996.061.01.025  0.797
1996 McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell. 87: 1339-49. PMID 8980239 DOI: 10.1016/S0092-8674(00)81828-0  0.82
1996 Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 87: 1327-38. PMID 8980238 DOI: 10.1016/S0092-8674(00)81827-9  0.806
1996 Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell. 87: 1317-26. PMID 8980237 DOI: 10.1016/S0092-8674(00)81826-7  0.68
1996 Moratalla R, Xu M, Tonegawa S, Graybiel AM. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 14928-33. PMID 8962158 DOI: 10.1073/Pnas.93.25.14928  0.658
1996 Chen C, Kim JJ, Thompson RF, Tonegawa S. Hippocampal lesions impair contextual fear conditioning in two strains of mice. Behavioral Neuroscience. 110: 1177-80. PMID 8919020 DOI: 10.1037/0735-7044.110.5.1177  0.334
1996 Ebralidze AK, Rossi DJ, Tonegawa S, Slater NT. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5014-25. PMID 8756432 DOI: 10.1523/Jneurosci.16-16-05014.1996  0.315
1996 Mizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK. Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. The Journal of Experimental Medicine. 183: 847-56. PMID 8642289 DOI: 10.1084/jem.183.3.847  0.305
1995 Hsia AY, Salin PA, Castillo PE, Aiba A, Abeliovich A, Tonegawa S, Nicoll RA. Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists. Neuropharmacology. 34: 1567-72. PMID 8606804 DOI: 10.1016/0028-3908(95)00115-M  0.309
1995 Kano M, Hashimoto K, Chen C, Abeliovich A, Aiba A, Kurihara H, Watanabe M, Inoue Y, Tonegawa S. Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Cell. 83: 1223-31. PMID 8548808 DOI: 10.1016/0092-8674(95)90147-7  0.31
1995 Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Ploegh HL. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. European Journal of Immunology. 25: 174-8. PMID 7843229 DOI: 10.1002/Eji.1830250129  0.304
1995 Martien van Santen H, Woolsey A, Rickardt PG, Van Kaer L, Baas EJ, Berns A, Tonegawa S, Ploegh HL. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. The Journal of Experimental Medicine. 181: 787-92. PMID 7836931 DOI: 10.1084/Jem.181.2.787  0.31
1995 Eichelberger M, McMickle A, Blackman M, Mombaerts P, Tonegawa S, Doherty PC. Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. Journal of Immunology (Baltimore, Md. : 1950). 154: 1569-76. PMID 7836742  0.53
1995 Ladel CH, Hess J, Daugelat S, Mombaerts P, Tonegawa S, Kaufmann SH. Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guérin: studies with T cell receptor-deficient mutant mice. European Journal of Immunology. 25: 838-46. PMID 7705416 DOI: 10.1002/eji.1830250331  0.586
1995 Levelt CN, Mombaerts P, Wang B, Kohler H, Tonegawa S, Eichmann K, Terhorst C. Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection. Immunity. 3: 215-22. PMID 7648394 DOI: 10.1016/1074-7613(95)90091-8  0.764
1995 Mombaerts P, Terhorst C, Jacks T, Tonegawa S, Sancho J. Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 92: 7420-4. PMID 7638208 DOI: 10.1073/Pnas.92.16.7420  0.571
1995 Tonegawa S. Mammalian learning and memory studied by gene targeting. Annals of the New York Academy of Sciences. 758: 213-7. PMID 7625692 DOI: 10.1111/j.1749-6632.1995.tb24828.x  0.367
1995 Butler LS, Silva AJ, Abeliovich A, Watanabe Y, Tonegawa S, McNamara JO. Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. Proceedings of the National Academy of Sciences of the United States of America. 92: 6852-5. PMID 7624331 DOI: 10.1073/Pnas.92.15.6852  0.557
1995 Komano H, Fujiura Y, Kawaguchi M, Matsumoto S, Hashimoto Y, Obana S, Mombaerts P, Tonegawa S, Yamamoto H, Itohara S. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 6147-51. PMID 7597094 DOI: 10.1073/pnas.92.13.6147  0.674
1995 Langhorne J, Mombaerts P, Tonegawa S. alpha beta and gamma delta T cells in the immune response to the erythrocytic stages of malaria in mice. International Immunology. 7: 1005-11. PMID 7577794 DOI: 10.1093/intimm/7.6.1005  0.588
1995 Poss KD, Thomas MJ, Ebralidze AK, O'Dell TJ, Tonegawa S. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 15: 867-73. PMID 7576635 DOI: 10.1016/0896-6273(95)90177-9  0.61
1995 Tonegawa S, Li Y, Erzurumlu RS, Jhaveri S, Chen C, Goda Y, Paylor R, Silva AJ, Kim JJ, Wehner JM. The gene knockout technology for the analysis of learning and memory, and neural development. Progress in Brain Research. 105: 3-14. PMID 7568891 DOI: 10.1016/S0079-6123(08)63279-3  0.588
1994 Li Y, Erzurumlu RS, Chen C, Jhaveri S, Tonegawa S. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell. 76: 427-37. PMID 8313466 DOI: 10.1016/0092-8674(94)90108-2  0.347
1994 Tsuji M, Mombaerts P, Lefrancois L, Nussenzweig RS, Zavala F, Tonegawa S. Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 345-9. PMID 8278391 DOI: 10.1073/Pnas.91.1.345  0.586
1994 Aldrich CJ, Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Forman J. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 6525-8. PMID 8022816 DOI: 10.1073/pnas.91.14.6525  0.31
1994 Ljunggren HG, Van Kaer L, Ploegh HL, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 6520-4. PMID 8022815 DOI: 10.1073/Pnas.91.14.6520  0.307
1994 Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, Tonegawa S. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell. 79: 945-55. PMID 8001143 DOI: 10.1016/0092-8674(94)90026-4  0.653
1994 Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 79: 729-42. PMID 7954836 DOI: 10.1016/0092-8674(94)90557-6  0.743
1994 Aiba A, Kano M, Chen C, Stanton ME, Fox GD, Herrup K, Zwingman TA, Tonegawa S. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell. 79: 377-88. PMID 7954803 DOI: 10.1016/0092-8674(94)90205-4  0.351
1994 Aiba A, Chen C, Herrup K, Rosenmund C, Stevens CF, Tonegawa S. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 79: 365-75. PMID 7954802 DOI: 10.1016/0092-8674(94)90204-6  0.376
1994 Chen C, Rainnie DG, Greene RW, Tonegawa S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science (New York, N.Y.). 266: 291-4. PMID 7939668 DOI: 10.1126/Science.7939668  0.327
1994 Mombaerts P, Anderson SJ, Perlmutter RM, Mak TW, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1: 261-7. PMID 7889413 DOI: 10.1016/1074-7613(94)90077-9  0.589
1994 Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1: 533-41. PMID 7600282 DOI: 10.1016/1074-7613(94)90043-4  0.324
1994 Godfrey DI, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. Journal of Immunology (Baltimore, Md. : 1950). 152: 4783-92. PMID 7513723  0.507
1993 Silva AJ, Paylor R, Wehner JM, Tonegawa S. Responses. Science (New York, N.Y.). 262: 761-2. PMID 17812342 DOI: 10.1126/science.262.5134.761  0.339
1993 Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke AR, Hooper ML, Farr A, Tonegawa S. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell. 72: 337-48. PMID 8381716 DOI: 10.1016/0092-8674(93)90112-4  0.682
1993 Mombaerts P, Arnoldi J, Russ F, Tonegawa S, Kaufmann SH. Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. Nature. 365: 53-6. PMID 8361537 DOI: 10.1038/365053a0  0.583
1993 Abeliovich A, Paylor R, Chen C, Kim JJ, Wehner JM, Tonegawa S. PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning. Cell. 75: 1263-71. PMID 8269510 DOI: 10.1016/0092-8674(93)90614-V  0.424
1993 Abeliovich A, Chen C, Goda Y, Silva AJ, Stevens CF, Tonegawa S. Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell. 75: 1253-62. PMID 8269509 DOI: 10.1016/0092-8674(93)90613-U  0.534
1993 Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proceedings of the National Academy of Sciences of the United States of America. 90: 11401-5. PMID 8248261 DOI: 10.1073/Pnas.90.23.11401  0.775
1993 Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell. 75: 274-82. PMID 8104709 DOI: 10.1016/0092-8674(93)80069-Q  0.604
1992 Abeliovich A, Gerber D, Tanaka O, Katsuki M, Graybiel AM, Tonegawa S. On somatic recombination in the central nervous system of transgenic mice. Science (New York, N.Y.). 257: 404-10. PMID 1631561 DOI: 10.1126/Science.1631561  0.522
1992 Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68: 869-77. PMID 1547488 DOI: 10.1016/0092-8674(92)90030-G  0.607
1992 Pereira P, Zijlstra M, McMaster J, Loring JM, Jaenisch R, Tonegawa S. Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. The Embo Journal. 11: 25-31. PMID 1531458 DOI: 10.1002/J.1460-2075.1992.Tb05023.X  0.312
1992 Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 71: 1205-14. PMID 1473153 DOI: 10.1016/S0092-8674(05)80068-6  0.317
1992 Silva AJ, Stevens CF, Tonegawa S, Wang Y. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (New York, N.Y.). 257: 201-6. PMID 1378648 DOI: 10.1126/Science.1378648  0.564
1992 Silva AJ, Wang Y, Paylor R, Wehner JM, Stevens CF, Tonegawa S. Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harbor Symposia On Quantitative Biology. 57: 527-39. PMID 1339689 DOI: 10.1101/Sqb.1992.057.01.058  0.508
1992 Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science (New York, N.Y.). 257: 206-11. PMID 1321493 DOI: 10.1126/Science.1321493  0.572
1991 Kappes DJ, Browne CP, Tonegawa S. Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain. Proceedings of the National Academy of Sciences of the United States of America. 88: 2204-8. PMID 2006158 DOI: 10.1073/Pnas.88.6.2204  0.311
1991 Bandeira A, Itohara S, Bonneville M, Burlen-Defranoux O, Mota-Santos T, Coutinho A, Tonegawa S. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. Proceedings of the National Academy of Sciences of the United States of America. 88: 43-7. PMID 1986381 DOI: 10.1073/Pnas.88.1.43  0.52
1991 Tonegawa S, Berns A, Bonneville M, Farr AG, Ishida I, Ito K, Itohara S, Janeway CA, Kanagawa O, Kubo R. Diversity, development, ligands, and probable functions of gamma delta T cells. Advances in Experimental Medicine and Biology. 292: 53-61. PMID 1835263  0.412
1991 Van Kaer L, Wu M, Ichikawa Y, Ito K, Bonneville M, Ostrand-Rosenberg S, Murphy DB, Tonegawa S. Recognition of MHC TL gene products by gamma delta T cells. Immunological Reviews. 120: 89-115. PMID 1830863 DOI: 10.1111/J.1600-065X.1991.Tb00589.X  0.31
1991 Mombaerts P, Clarke AR, Hooper ML, Tonegawa S. Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proceedings of the National Academy of Sciences of the United States of America. 88: 3084-7. PMID 1826563 DOI: 10.1073/Pnas.88.8.3084  0.574
1991 Wu M, van Kaer L, Itohara S, Tonegawa S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. The Journal of Experimental Medicine. 174: 213-8. PMID 1711563 DOI: 10.1084/Jem.174.1.213  0.523
1990 Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB, Tonegawa S. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell. 62: 549-61. PMID 2379238 DOI: 10.1016/0092-8674(90)90019-B  0.302
1990 Ishida I, Verbeek S, Bonneville M, Itohara S, Berns A, Tonegawa S. T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 3067-71. PMID 2326267 DOI: 10.1073/Pnas.87.8.3067  0.516
1990 Bonneville M, Ishida I, Itohara S, Verbeek S, Berns A, Kanagawa O, Haas W, Tonegawa S. Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation. Nature. 344: 163-5. PMID 2308634 DOI: 10.1038/344163a0  0.535
1990 Itohara S, Tonegawa S. Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. Proceedings of the National Academy of Sciences of the United States of America. 87: 7935-8. PMID 2236011 DOI: 10.1073/Pnas.87.20.7935  0.508
1990 Itohara S, Farr AG, Lafaille JJ, Bonneville M, Takagaki Y, Haas W, Tonegawa S. Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature. 343: 754-7. PMID 2154700 DOI: 10.1038/343754a0  0.451
1990 Bandeira A, Mota-Santos T, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A. Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization. The Journal of Experimental Medicine. 172: 239-44. PMID 2141628  0.445
1990 Farr A, Hosier S, Nelson A, Itohara S, Tonegawa S. Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development. Journal of Immunology (Baltimore, Md. : 1950). 144: 492-8. PMID 2136893  0.444
1990 Bonneville M, Itohara S, Krecko EG, Mombaerts P, Ishida I, Katsuki M, Berns A, Farr AG, Janeway CA, Tonegawa S. Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity. The Journal of Experimental Medicine. 171: 1015-26. PMID 2109035 DOI: 10.1084/Jem.171.4.1015  0.679
1989 Bonneville M, Ito K, Krecko EG, Itohara S, Kappes D, Ishida I, Kanagawa O, Janeway CA, Murphy DB, Tonegawa S. Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors. Proceedings of the National Academy of Sciences of the United States of America. 86: 5928-32. PMID 2788280 DOI: 10.1073/pnas.86.15.5928  0.528
1989 Itohara S, Nakanishi N, Kanagawa O, Kubo R, Tonegawa S. Monoclonal antibodies specific to native murine T-cell receptor gamma delta: analysis of gamma delta T cells during thymic ontogeny and in peripheral lymphoid organs. Proceedings of the National Academy of Sciences of the United States of America. 86: 5094-8. PMID 2787028 DOI: 10.1073/Pnas.86.13.5094  0.508
1989 Lafaille JJ, DeCloux A, Bonneville M, Takagaki Y, Tonegawa S. Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining. Cell. 59: 859-70. PMID 2590942 DOI: 10.1016/0092-8674(89)90609-0  0.303
1989 Takagaki Y, DeCloux A, Bonneville M, Tonegawa S. Diversity of gamma delta T-cell receptors on murine intestinal intra-epithelial lymphocytes. Nature. 339: 712-4. PMID 2544806 DOI: 10.1038/339712a0  0.318
1989 Tonegawa S, Berns A, Bonneville M, Farr A, Ishida I, Ito K, Itohara S, Janeway CA, Kanagawa O, Katsuki M. Diversity, development, ligands, and probable functions of gamma delta T cells. Cold Spring Harbor Symposia On Quantitative Biology. 54: 31-44. PMID 2534795  0.412
1989 Minoprio P, Itohara S, Heusser C, Tonegawa S, Coutinho A. Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells. Immunological Reviews. 112: 183-207. PMID 2514135 DOI: 10.1111/J.1600-065X.1989.Tb00558.X  0.452
1989 Bonneville M, Ishida I, Mombaerts P, Katsuki M, Verbeek S, Berns A, Tonegawa S. Blockage of alpha beta T-cell development by TCR gamma delta transgenes. Nature. 342: 931-4. PMID 2480528 DOI: 10.1038/342931a0  0.582
1989 Ito K, Bonneville M, Takagaki Y, Nakanishi N, Kanagawa O, Krecko EG, Tonegawa S. Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development. Proceedings of the National Academy of Sciences of the United States of America. 86: 631-5. PMID 2463632 DOI: 10.1073/Pnas.86.2.631  0.304
1989 Tonegawa S, Berns A, Bonneville M, Farr AG, Ishida I, Ito K, Itohara S, Janeway CA, Kanagawa O, Katsuiki M, Kubo R, Lafaille JJ, Mombaerts P, Murphy DB, Nakanishi N, et al. Diversity, Development, Ligands, and Probable Functions of γδ T Cells Cold Spring Harbor Symposia On Quantitative Biology. 54: 243-257. DOI: 10.1007/978-3-642-83755-5_34  0.512
1988 von Boehmer H, Bonneville M, Ishida I, Ryser S, Lincoln G, Smith RT, Kishi H, Scott B, Kisielow P, Tonegawa S. Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment. Proceedings of the National Academy of Sciences of the United States of America. 85: 9729-32. PMID 2974164 DOI: 10.1073/Pnas.85.24.9729  0.306
1988 Bonneville M, Janeway CA, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S. Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. Nature. 336: 479-81. PMID 2461518 DOI: 10.1038/336479a0  0.3
1986 Reilly EB, Kranz DM, Tonegawa S, Eisen HN. A functional gamma gene formed from known gamma-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes. Nature. 321: 878-80. PMID 3487735 DOI: 10.1038/321878A0  0.308
1985 Hayday AC, Saito H, Gillies SD, Kranz DM, Tanigawa G, Eisen HN, Tonegawa S. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell. 40: 259-69. PMID 3917858 DOI: 10.1016/0092-8674(85)90140-0  0.519
1985 Hayday AC, Diamond DJ, Tanigawa G, Heilig JS, Folsom V, Saito H, Tonegawa S. Unusual organization and diversity of T-cell receptor alpha-chain genes. Nature. 316: 828-32. PMID 2993907 DOI: 10.1038/316828A0  0.53
1985 Raulet DH, Garman RD, Saito H, Tonegawa S. Developmental regulation of T-cell receptor gene expression. Nature. 314: 103-7. PMID 2983227 DOI: 10.1038/314103A0  0.31
1985 Heilig JS, Glimcher LH, Kranz DM, Clayton LK, Greenstein JL, Saito H, Maxam AM, Burakoff SJ, Eisen HN, Tonegawa S. Expression of the T-cell-specific gamma gene is unnecessary in T cells recognizing class II MHC determinants. Nature. 317: 68-70. PMID 2412133 DOI: 10.1038/317068A0  0.303
1985 Yamamura K, Kikutani H, Folsom V, Clayton LK, Kimoto M, Akira S, Kashiwamura S, Tonegawa S, Kishimoto T. Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice. Nature. 316: 67-9. PMID 2409451 DOI: 10.1038/316067a0  0.302
1984 Wiman KG, Clarkson B, Hayday AC, Saito H, Tonegawa S, Hayward WS. Activation of a translocated c-myc gene: role of structural alterations in the upstream region. Proceedings of the National Academy of Sciences of the United States of America. 81: 6798-802. PMID 6593728 DOI: 10.1073/Pnas.81.21.6798  0.49
1984 Hayday AC, Gillies SD, Saito H, Wood C, Wiman K, Hayward WS, Tonegawa S. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature. 307: 334-40. PMID 6420706 DOI: 10.1038/307334A0  0.594
1984 Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature. 309: 757-62. PMID 6330561 DOI: 10.1038/309757A0  0.521
1984 Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature. 312: 36-40. PMID 6208487 DOI: 10.1038/312036A0  0.518
1984 Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The Embo Journal. 3: 1209-19. PMID 6086308 DOI: 10.1002/J.1460-2075.1984.Tb01955.X  0.468
1983 Wood C, Tonegawa S. Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism. Proceedings of the National Academy of Sciences of the United States of America. 80: 3030-4. PMID 6407007 DOI: 10.1073/Pnas.80.10.3030  0.451
1983 Saito H, Hayday AC, Wiman K, Hayward WS, Tonegawa S. Activation of the c-myc gene by translocation: a model for translational control. Proceedings of the National Academy of Sciences of the United States of America. 80: 7476-80. PMID 6324175 DOI: 10.1073/Pnas.80.24.7476  0.493
1982 Kurosawa Y, Tonegawa S. Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. The Journal of Experimental Medicine. 155: 201-18. PMID 6798155 DOI: 10.1084/Jem.155.1.201  0.463
1981 Tonegawa S, Sakano H, Make R, Traunecker A, Heinrich G, Roeder W, Kurosawa Y. Somatic reorganization of immunoglobulin genes during lymphocyte differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 45: 839-58. PMID 6790217  0.578
1981 Kurosawa Y, von Boehmer H, Haas W, Sakano H, Trauneker A, Tonegawa S. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature. 290: 565-70. PMID 6783962 DOI: 10.1038/290565A0  0.63
1981 Sakano H, Kurosawa Y, Weigert M, Tonegawa S. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature. 290: 562-5. PMID 6783961 DOI: 10.1038/290562A0  0.612
1980 Sakano H, Maki R, Kurosawa Y, Roeder W, Tonegawa S. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature. 286: 676-83. PMID 6774258 DOI: 10.1038/286676A0  0.618
1980 Maki R, Traunecker A, Sakano H, Roeder W, Tonegawa S. Exon shuffling generates an immunoglobulin heavy chain gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 2138-42. PMID 6769120 DOI: 10.1073/Pnas.77.4.2138  0.507
1979 Sakano H, Hüppi K, Heinrich G, Tonegawa S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature. 280: 288-94. PMID 111144 DOI: 10.1038/280288a0  0.498
1979 Sakano H, Rogers JH, Hüppi K, Brack C, Traunecker A, Maki R, Wall R, Tonegawa S. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature. 277: 627-33. PMID 106304 DOI: 10.1038/277627a0  0.49
1970 Tonegawa S, Hayashi M. Intermediates in the assembly of phi X174. Journal of Molecular Biology. 48: 219-42. PMID 4915298 DOI: 10.1016/0022-2836(70)90158-0  0.557
1966 Tonegawa S, Hayashi M. The direction of in vitro genetic transcription on circular DNA. Biochimica Et Biophysica Acta. 123: 634-7. PMID 4291287 DOI: 10.1016/0005-2787(66)90236-X  0.558
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