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Bhushan Nagar, Ph.D. - Publications

Affiliations: 
2001 University of Toronto, Toronto, ON, Canada 
Area:
sturucture of glycosyltransferases
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gorelik A, Labriola JM, Illes K, Nagar B. Crystal structure of the nucleotide-metabolizing enzyme NTPDase4. Protein Science : a Publication of the Protein Society. PMID 32767432 DOI: 10.1002/Pro.3926  0.383
2020 Gorelik A, Illes K, Nagar B. Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme. Structure (London, England : 1993). PMID 32109365 DOI: 10.1016/J.Str.2020.02.001  0.398
2018 Dementiev A, Joachimiak A, Nguyen H, Gorelik A, Illes K, Shabani S, Gelsomino M, Ahn EE, Nagar B, Doan N. Molecular mechanism of inhibition of acid ceramidase by carmofur. Journal of Medicinal Chemistry. PMID 30525581 DOI: 10.2210/Pdb6Mhm/Pdb  0.326
2018 Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B. Molecular mechanism of activation of the immunoregulatory amidase NAAA. Proceedings of the National Academy of Sciences of the United States of America. PMID 30301806 DOI: 10.1073/Pnas.1811759115  0.372
2018 Gebai A, Gorelik A, Nagar B. Crystal structure of saposin D in an open conformation. Journal of Structural Biology. PMID 30026085 DOI: 10.1016/J.Jsb.2018.07.011  0.339
2018 Labriola J, Zhou Y, Nagar B. Structural analysis of the bacterial effector, AvrA, identifies a critical helix involved in MKK4-substrate recognition. Biochemistry. PMID 30025209 DOI: 10.1021/Acs.Biochem.8B00512  0.439
2018 Gorelik A, Randriamihaja A, Illes K, Nagar B. Structural Basis for Nucleotide Recognition by the Ectoenzyme CD203c. The Febs Journal. PMID 29717535 DOI: 10.1111/Febs.14489  0.351
2018 Gebai A, Gorelik A, Li Z, Illes K, Nagar B. Structural basis for the activation of acid ceramidase. Nature Communications. 9: 1621. PMID 29692406 DOI: 10.2210/Pdb5U84/Pdb  0.357
2018 Gorelik A, Illes K, Nagar B. Crystal structure of the mammalian lipopolysaccharide detoxifier. Proceedings of the National Academy of Sciences of the United States of America. PMID 29343645 DOI: 10.1073/Pnas.1719834115  0.32
2017 Gorelik A, Randriamihaja A, Illes K, Nagar B. A Key Tyrosine Substitution Restricts Nucleotide Hydrolysis by the Ectoenzyme NPP5. The Febs Journal. PMID 28898552 DOI: 10.1111/Febs.14266  0.372
2017 Frank F, Nagar B. Structural and Functional Characterization of Plant ARGONAUTE MID Domains. Methods in Molecular Biology (Clifton, N.J.). 1640: 227-239. PMID 28608347 DOI: 10.1007/978-1-4939-7165-7_17  0.364
2017 Gorelik A, Liu F, Illes K, Nagar B. Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition. The Journal of Biological Chemistry. PMID 28292932 DOI: 10.1074/Jbc.M116.769273  0.366
2017 Abbas YM, Laudenbach BT, Martínez-Montero S, Cencic R, Habjan M, Pichlmair A, Damha MJ, Pelletier J, Nagar B. Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28251928 DOI: 10.1073/Pnas.1612444114  0.306
2016 Gorelik A, Heinz LX, Illes K, Superti-Furga G, Nagar B. Crystal Structure of the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. The Journal of Biological Chemistry. PMID 27687724 DOI: 10.1074/Jbc.M116.755801  0.378
2016 Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B. Crystal structure of mammalian acid sphingomyelinase. Nature Communications. 7: 12196. PMID 27435900 DOI: 10.1038/Ncomms12196  0.432
2016 Gorelik A, Illes K, Superti-Furga G, Nagar B. Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3A. The Journal of Biological Chemistry. PMID 26792860 DOI: 10.1074/Jbc.M115.711085  0.415
2014 Dimech C, Nagar B. Towards a structural characterization of the IFIT antiviral complex Acta Crystallographica Section a Foundations and Advances. 70: C246-C246. DOI: 10.1107/S2053273314097538  0.363
2014 Sabboobeh S, Nagar B. Structural Characterization of Human Immunity-Related GTPase Family M (IRGM) Acta Crystallographica Section a Foundations and Advances. 70: C835-C835. DOI: 10.1107/S2053273314091645  0.332
2014 Seirafi M, Trempe J, Sauve V, Kozlov G, Menade M, Nagar B, Gehring k. Structure of parkin reveals the mechanism of autoinhibition Acta Crystallographica Section a Foundations and Advances. 70: C838-C838. DOI: 10.1107/S205327331409161X  0.389
2014 Abbas Y, Xie IY, Nagar B. Crystal structure of N-terminal IFIT3 reveals domain-swapping dimerization Acta Crystallographica Section a Foundations and Advances. 70: C1629-C1629. DOI: 10.1107/S2053273314083703  0.442
2013 Trempe JF, Sauvé V, Grenier K, Seirafi M, Tang MY, Ménade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science (New York, N.Y.). 340: 1451-5. PMID 23661642 DOI: 10.1126/Science.1237908  0.367
2013 Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nature Structural & Molecular Biology. 20: 735-9. PMID 23644599 DOI: 10.1038/Nsmb.2572  0.387
2013 Ishiyama N, Tanaka N, Abe K, Yang YJ, Abbas YM, Umitsu M, Nagar B, Bueler SA, Rubinstein JL, Takeichi M, Ikura M. An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions. The Journal of Biological Chemistry. 288: 15913-25. PMID 23589308 DOI: 10.1074/Jbc.M113.453928  0.321
2013 Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B. Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure (London, England : 1993). 21: 517-27. PMID 23478064 DOI: 10.1016/J.Str.2013.01.015  0.414
2013 Deleavey GF, Frank F, Hassler M, Wisnovsky S, Nagar B, Damha MJ. The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues. Nucleic Acid Therapeutics. 23: 81-7. PMID 23289589 DOI: 10.1089/Nat.2012.0393  0.306
2012 Frank F, Hauver J, Sonenberg N, Nagar B. Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The Embo Journal. 31: 3588-95. PMID 22850669 DOI: 10.1038/Emboj.2012.204  0.366
2012 Amaefuna SC, Harrington AM, Jean-Claude B, Nagar B, Henderson MN. Crystallization of the Abl Kinase Domain with Combi-Inhibitors, ZRF1 and ZRF2 Biophysical Journal. 102: 61a. DOI: 10.1016/J.Bpj.2011.11.364  0.378
2011 Frank F, Fabian MR, Stepinski J, Jemielity J, Darzynkiewicz E, Sonenberg N, Nagar B. Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Reports. 12: 415-20. PMID 21475248 DOI: 10.1038/Embor.2011.48  0.338
2011 Virgili G, Varlan I, Illes K, Nagar B. Structural studies on piRNA recognition by mammalian PIWI-like Argonaute proteins Acta Crystallographica Section a Foundations of Crystallography. 67: C658-C658. DOI: 10.1107/S0108767311083371  0.313
2010 Frank F, Sonenberg N, Nagar B. Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature. 465: 818-22. PMID 20505670 DOI: 10.1038/Nature09039  0.357
2010 Frank F, Virgili G, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 15-9. PMID 20057060 DOI: 10.1107/S1744309109044315  0.381
2009 Kanaan AS, Frank F, Maedler-Kron C, Verma K, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1060-4. PMID 19851022 DOI: 10.1107/S1744309109036513  0.377
2008 Nagar B. Structural biology in the battle against BCR-Abl Expert Opinion On Therapeutic Patents. 18: 975-988. DOI: 10.1517/13543776.18.9.975  0.305
2007 Nagar B. c-Abl tyrosine kinase and inhibition by the cancer drug imatinib (Gleevec/STI-571). The Journal of Nutrition. 137: 1518S-1523S; discuss. PMID 17513418 DOI: 10.1093/Jn/137.6.1518S  0.429
2007 Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty Structure. 15: 299-311. PMID 17355866 DOI: 10.1016/J.Str.2007.01.015  0.706
2006 Kozlov G, Maattanen P, Schrag JD, Pollock S, Cygler M, Nagar B, Thomas DY, Gehring K. Crystal structure of the bb' domains of the protein disulfide isomerase ERp57. Structure (London, England : 1993). 14: 1331-9. PMID 16905107 DOI: 10.1016/J.Str.2006.06.019  0.393
2006 Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase Molecular Cell. 21: 787-798. PMID 16543148 DOI: 10.1016/J.Molcel.2006.01.035  0.713
2005 Sondermann H, Nagar B, Bar-Sagi D, Kuriyan J. Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless Proceedings of the National Academy of Sciences of the United States of America. 102: 16632-16637. PMID 16267129 DOI: 10.1073/Pnas.0508315102  0.705
2005 Nagar B, Kuriyan J. SAXS and the working protein Structure. 13: 169-173. PMID 15698559 DOI: 10.1016/J.Str.2005.01.001  0.51
2004 Walker JR, Nagar B, Young NM, Hirama T, Rini JM. X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure. Biochemistry. 43: 3783-92. PMID 15049685 DOI: 10.1021/Bi035871A  0.663
2003 Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell. 112: 859-871. PMID 12654251 DOI: 10.1016/S0092-8674(03)00194-6  0.608
2003 Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G. A myristoyl/phosphotyrosine switch regulates c-Abl Cell. 112: 845-857. PMID 12654250 DOI: 10.1016/S0092-8674(03)00191-0  0.591
2003 Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 112: 685-95. PMID 12628188 DOI: 10.1016/S0092-8674(03)00149-1  0.636
2002 Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, Sawyers CL. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2: 117-25. PMID 12204532 DOI: 10.1016/S1535-6108(02)00096-X  0.531
2002 Wisniewski D, Lambek CL, Liu C, Strife A, Veach DR, Nagar B, Young MA, Schindler T, Bornmann WG, Bertino JR, Kuriyan J, Clarkson B. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases Cancer Research. 62: 4244-4255. PMID 12154026  0.459
2002 Nagar B, Bornmann WG, Pellicena P, Schindler T, Veach DR, Miller WT, Clarkson B, Kuriyan J. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Research. 62: 4236-43. PMID 12154025 DOI: 10.2210/Pdb1Iep/Pdb  0.586
1998 Smith GD, Nagar B, Rini JM, Hauptman HA, Blessing RH. The use of SnB to determine an anomalous scattering substructure. Acta Crystallographica. Section D, Biological Crystallography. 54: 799-804. PMID 9757093 DOI: 10.1107/S0907444997018805  0.513
1998 Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM. X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2. Science (New York, N.Y.). 280: 1277-81. PMID 9596584 DOI: 10.1126/Science.280.5367.1277  0.626
1998 Isenman D, Nagar B, Jones R, Clemenza L, Diefenbach R, Rini J. X-ray crystal structure of complement fragment C3d: The ligand for CR2 Molecular Immunology. 35: 359. DOI: 10.1016/S0161-5890(98)90645-9  0.567
1996 Nagar B, Overduin M, Ikura M, Rini JM. Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature. 380: 360-4. PMID 8598933 DOI: 10.1107/S0108767396092318  0.626
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