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Rachel A. Powers, Ph.D. - Publications

Affiliations: 
2002 Northwestern University, Evanston, IL 
Area:
GPCR, computational chemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Powers RA, June CM, Fernando MC, Fish ER, Maurer OL, Baumann RM, Beardsley TJ, Taracila MA, Rudin SD, Hujer KM, Hujer AM, Santi N, Villamil V, Introvigne ML, Prati F, et al. Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. Journal of Medicinal Chemistry. PMID 37358467 DOI: 10.1021/acs.jmedchem.3c00144  0.428
2023 Introvigne ML, Beardsley TJ, Fernando MC, Leonard DA, Wallar BJ, Rudin SD, Taracila MA, Rather PN, Colquhoun JM, Song S, Fini F, Hujer KM, Hujer AM, Prati F, Powers RA, et al. Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in . Antibiotics (Basel, Switzerland). 12. PMID 37107006 DOI: 10.3390/antibiotics12040644  0.388
2022 Mitchell JM, June CM, Baggett VL, Lowe BC, Ruble JF, Bonomo RA, Leonard DA, Powers RA. Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. The Journal of Biological Chemistry. 102127. PMID 35709986 DOI: 10.1016/j.jbc.2022.102127  0.42
2020 Curtis BN, Smolen KA, Barlow SJ, Caselli E, Prati F, Taracila MA, Bonomo RA, Wallar BJ, Powers RA. Structural insights into inhibition of the derived cephalosporinase ADC-7 by ceftazidime and its boronic acid transition state analog. Antimicrobial Agents and Chemotherapy. PMID 32988830 DOI: 10.1128/AAC.01183-20  0.447
2020 Caselli E, Fini F, Introvigne ML, Stucchii M, Taracila MA, Fish E, Smolen K, Rather PN, Powers RA, Wallar BJ, Bonomo RA, Prati F. 1,2,3-Triazolylmethaneboronate: a Structure Activity Relationship Study of a New Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase (ADC-7). Acs Infectious Diseases. PMID 32502340 DOI: 10.1021/Acsinfecdis.0C00254  0.543
2018 Powers R, Mitchell J, Basinski B, Pham U. Structure-based discovery and optimization of inhibitors for the class D β-lactamase OXA-24/40 Acta Crystallographica Section a Foundations and Advances. 74: a394-a394. DOI: 10.1107/S010876731809606X  0.448
2017 Harper TM, June CM, Taracila MA, Bonomo RA, Powers RA, Leonard DA. Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239. The Biochemical Journal. PMID 29229762 DOI: 10.1042/Bcj20170702  0.464
2017 Caselli E, Romagnoli C, Powers RA, Taracila MA, Bouza AA, Swanson HC, Smolen KA, Fini F, Wallar BJ, Bonomo RA, Prati F. Inhibition of Acinetobacter-Derived Cephalosporinase (ADC): Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors. Acs Infectious Diseases. PMID 29144725 DOI: 10.1021/Acsinfecdis.7B00153  0.5
2017 Bouza AA, Swanson HC, Smolen KA, VanDine AL, Taracila MA, Romagnoli C, Caselli E, Prati F, Bonomo RA, Powers RA, Wallar BJ. Structure-based analysis of boronic acids as inhibitors of Acinetobacter-derived cephalosporinase-7 (ADC-7), a unique class C β-lactamase. Acs Infectious Diseases. PMID 29144724 DOI: 10.1021/Acsinfecdis.7B00152  0.558
2017 Springsdorf R, Mutete D, Morales A, Werner J, Mitchell J, Powers R. Novel boronic acid inhibitors of the class D β-lactamase OXA-24 Acta Crystallographica Section a Foundations and Advances. 73: a355-a355. DOI: 10.1107/S0108767317096532  0.444
2016 Werner JP, Mitchell JM, Taracila MA, Bonomo RA, Powers RA. Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase. Protein Science : a Publication of the Protein Society. PMID 27997706 DOI: 10.1002/Pro.3100  0.514
2016 June CM, Muckenthaler TJ, Schroder EC, Klamer ZL, Wawrzak Z, Powers RA, Szarecka A, Leonard DA. The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity. Protein Science : a Publication of the Protein Society. PMID 27636561 DOI: 10.1002/Pro.3040  0.476
2015 Powers RA. Structural and Functional Aspects of Extended-Spectrum AmpC cephalosporinases. Current Drug Targets. PMID 26073861 DOI: 10.2174/1573399811666150615144707  0.475
2015 Mitchell JM, Clasman JR, June CM, Kaitany KC, LaFleur JR, Taracila MA, Klinger NV, Bonomo RA, Wymore T, Szarecka A, Powers RA, Leonard DA. Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii. Biochemistry. 54: 1976-87. PMID 25710192 DOI: 10.1021/Bi501547K  0.479
2014 Powers RA, Swanson HC, Taracila MA, Florek NW, Romagnoli C, Caselli E, Prati F, Bonomo RA, Wallar BJ. Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii. Biochemistry. 53: 7670-9. PMID 25380506 DOI: 10.1021/Bi500887N  0.538
2014 Hendershot JM, Mishra UJ, Smart RP, Schroeder W, Powers RA. Structure-based efforts to optimize a non-β-lactam inhibitor of AmpC β-lactamase. Bioorganic & Medicinal Chemistry. 22: 3351-9. PMID 24835785 DOI: 10.1016/J.Bmc.2014.04.051  0.494
2014 June CM, Vallier BC, Bonomo RA, Leonard DA, Powers RA. Structural origins of oxacillinase specificity in class D β-lactamases. Antimicrobial Agents and Chemotherapy. 58: 333-41. PMID 24165180 DOI: 10.1128/Aac.01483-13  0.538
2013 Leonard DA, Bonomo RA, Powers RA. Class D β-lactamases: a reappraisal after five decades. Accounts of Chemical Research. 46: 2407-15. PMID 23902256 DOI: 10.1021/Ar300327A  0.482
2013 Kaitany KC, Klinger NV, June CM, Ramey ME, Bonomo RA, Powers RA, Leonard DA. Structures of the class D Carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam. Antimicrobial Agents and Chemotherapy. 57: 4848-55. PMID 23877677 DOI: 10.1128/Aac.00762-13  0.492
2012 Ruble JF, Lefurgy ST, Cornish VW, Powers RA. Structural analysis of the Asn152Gly mutant of P99 cephalosporinase. Acta Crystallographica. Section D, Biological Crystallography. 68: 1189-93. PMID 22948919 DOI: 10.1107/S0907444912024080  0.415
2011 Schneider KD, Ortega CJ, Renck NA, Bonomo RA, Powers RA, Leonard DA. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. Journal of Molecular Biology. 406: 583-94. PMID 21215758 DOI: 10.1016/J.Jmb.2010.12.042  0.509
2009 Schneider KD, Karpen ME, Bonomo RA, Leonard DA, Powers RA. The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem. Biochemistry. 48: 11840-7. PMID 19919101 DOI: 10.1021/Bi901690R  0.554
2006 Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM. Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato. Acta Crystallographica. Section D, Biological Crystallography. 62: 683-6. PMID 16699197 DOI: 10.1107/S0907444906014107  0.345
2002 Powers RA, Morandi F, Shoichet BK. Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase. Structure (London, England : 1993). 10: 1013-23. PMID 12121656 DOI: 10.1016/S0969-2126(02)00799-2  0.683
2002 Powers RA, Shoichet BK. Structure-based approach for binding site identification on AmpC beta-lactamase. Journal of Medicinal Chemistry. 45: 3222-34. PMID 12109906 DOI: 10.1021/Jm020002P  0.626
2001 Powers RA, Caselli E, Focia PJ, Prati F, Shoichet BK. Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry. 40: 9207-14. PMID 11478888 DOI: 10.1021/Bi0109358  0.667
2001 Tondi D, Powers RA, Caselli E, Negri MC, Blázquez J, Costi MP, Shoichet BK. Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase. Chemistry & Biology. 8: 593-611. PMID 11410378 DOI: 10.1016/S1074-5521(01)00034-5  0.681
2001 Caselli E, Powers RA, Blasczcak LC, Wu CY, Prati F, Shoichet BK. Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases. Chemistry & Biology. 8: 17-31. PMID 11182316 DOI: 10.1016/S1074-5521(00)00052-1  0.651
1999 Powers RA, Blázquez J, Weston GS, Morosini MI, Baquero F, Shoichet BK. The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Science : a Publication of the Protein Society. 8: 2330-7. PMID 10595535 DOI: 10.1110/Ps.8.11.2330  0.666
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