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Binqing Wei, Ph.D. - Publications

Affiliations: 
2003 Northwestern University, Evanston, IL 
Area:
GPCR, computational chemistry
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Staben LR, Chen J, Cruz-Chuh JD, Del Rosario G, Go MA, Guo J, Khojasteh SC, Kozak KR, Li G, Ng C, Lewis Phillips G, Pillow TH, Rowntree RK, Wai J, Wei B, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. Journal of Medicinal Chemistry. PMID 32787101 DOI: 10.1021/Acs.Jmedchem.0C00691  0.387
2019 Dragovich PS, Adhikari P, Blake RA, Blaquiere N, Chen J, Cheng YX, den Besten W, Han J, Hartman SJ, He J, He M, Rei Ingalla E, Kamath AV, Kleinheinz T, Lai T, ... ... Wei B, et al. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907. PMID 31902710 DOI: 10.1016/J.Bmcl.2019.126907  0.319
2019 Su D, Chen J, Cosino E, Cruz-Chuh JD, Davis H, Del Rosario G, Figueroa I, Goon L, He J, Kamath A, Kaur S, Kozak K, Lau J, Lee D, Lee MV, ... ... Wei B, et al. Antibody-drug Conjugates Derived From Cytotoxic seco-CBI-Dimer Payloads are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate Chemistry. PMID 30966735 DOI: 10.1021/Acs.Bioconjchem.9B00133  0.381
2018 Ohri R, Bhakta S, Fourie-O'Donohue A, Dela Cruz-Chuh J, Tsai SP, Cook R, Wei B, Ng C, Wong AW, Bos AB, Farahi F, Bhakta J, Pillow TH, Raab H, Vandlen R, et al. High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers. Bioconjugate Chemistry. PMID 29425028 DOI: 10.1021/Acs.Bioconjchem.7B00791  0.314
2018 Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis-Phillips GD, Vollmar B, Sadowsky J, Vandlen R, Wei B, Su D, et al. Immolation of p-aminobenzyl ether linker and payload potency and stability determine the cell killing activity of antibody-drug conjugates with phenol-containing payloads. Bioconjugate Chemistry. PMID 29369629 DOI: 10.1021/Acs.Bioconjchem.7B00576  0.326
2017 Wei B, Gunzner-Toste J, Yao H, Wang T, Wang J, Xu Z, Chen J, Wai J, Nonomiya J, Tsai SP, Cruz-Chuh JD, Kozak KR, Liu Y, Yu SF, Lau J, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. Journal of Medicinal Chemistry. PMID 29227683 DOI: 10.1021/Acs.Jmedchem.7B01430  0.34
2017 Gregson SJ, Masterson LA, Wei B, Pillow TH, Spencer SD, Kang GD, Yu SF, Raab H, Lau J, Li G, Lewis Phillips GD, Gunzner-Toste J, Safina BS, Ohri R, Darwish M, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Non-Cleavable Drug-Linkers. Journal of Medicinal Chemistry. PMID 29112410 DOI: 10.1021/Acs.Jmedchem.7B00736  0.32
2017 Safina BS, Elliott RL, Forrest AK, Heald RA, Murray JM, Nonomiya J, Pang J, Salphati L, Seward EM, Staben ST, Ultsch M, Wei B, Yang W, Sutherlin DP. Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles. Acs Medicinal Chemistry Letters. 8: 936-940. PMID 28947940 DOI: 10.1021/Acsmedchemlett.7B00170  0.396
2017 Vollmar BS, Wei B, Ohri R, Zhou J, He J, Yu SF, Leipold D, Cosino E, Yee S, Fourie-O'Donohue A, Li G, Lewis Phillips GD, Kozak KR, Kamath A, Xu K, et al. Attachment site cysteine thiol pKa is a key driver for site-dependent stability of THIOMAB(TM) antibody-drug conjugates. Bioconjugate Chemistry. PMID 28885827 DOI: 10.1021/Acs.Bioconjchem.7B00365  0.307
2016 Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, ... ... Wei B, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119. PMID 27874860 DOI: 10.1038/Nchem.2635  0.403
2016 Purkey HE, Robarge K, Chen J, Chen Z, Corson LB, Ding CZ, DiPasquale AG, Dragovich PS, Eigenbrot C, Evangelista M, Fauber BP, Gao Z, Ge H, Hitz A, Ho Q, ... ... Wei B, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Medicinal Chemistry Letters. 7: 896-901. PMID 27774125 DOI: 10.1021/Acsmedchemlett.6B00190  0.328
2016 Heffron TP, Heald RA, Ndubaku CO, Wei B, Augustin M, Do S, Edgar K, Eigenbrot C, Lori F, Gancia E, Jackson P, Jones G, Kolesnikov A, Lee L, Lesnick J, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the -Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). Journal of Medicinal Chemistry. PMID 26741947 DOI: 10.1021/Acs.Jmedchem.5B01483  0.38
2015 Labadie S, Dragovich PS, Chen J, Fauber BP, Boggs J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Ho Q, Lai KW, Ma S, Malek S, Peterson D, Purkey HE, ... ... Wei B, et al. Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 25: 75-82. PMID 25466195 DOI: 10.1016/J.Bmcl.2014.11.008  0.369
2014 Fauber BP, Dragovich PS, Chen J, Corson LB, Ding CZ, Eigenbrot C, Labadie S, Malek S, Peterson D, Purkey HE, Robarge K, Sideris S, Ultsch M, Wei B, Yen I, et al. Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 24: 5683-7. PMID 25467161 DOI: 10.1016/J.Bmcl.2014.10.067  0.32
2014 Dragovich PS, Fauber BP, Boggs J, Chen J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Li C, Liu Y, Liu Y, Ma S, ... ... Wei B, et al. Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 24: 3764-71. PMID 25037916 DOI: 10.1016/J.Bmcl.2014.06.076  0.362
2013 Fauber BP, Dragovich PS, Chen J, Corson LB, Ding CZ, Eigenbrot C, Giannetti AM, Hunsaker T, Labadie S, Liu Y, Liu Y, Malek S, Peterson D, Pitts K, Sideris S, ... ... Wei B, et al. Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 23: 5533-9. PMID 24012183 DOI: 10.1016/J.Bmcl.2013.08.060  0.351
2013 Safina BS, Sweeney ZK, Li J, Chan BK, Bisconte A, Carrera D, Castanedo G, Flagella M, Heald R, Lewis C, Murray JM, Nonomiya J, Pang J, Price S, Reif K, ... ... Wei B, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 23: 4953-9. PMID 23867164 DOI: 10.1016/J.Bmcl.2013.06.052  0.352
2013 Ndubaku CO, Heffron TP, Staben ST, Baumgardner M, Blaquiere N, Bradley E, Bull R, Do S, Dotson J, Dudley D, Edgar KA, Friedman LS, Goldsmith R, Heald RA, Kolesnikov A, ... ... Wei B, et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. Journal of Medicinal Chemistry. 56: 4597-610. PMID 23662903 DOI: 10.1021/Jm4003632  0.375
2013 Dragovich PS, Fauber BP, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Liu Y, Malek S, Pan B, Peterson D, Pitts K, Purkey HE, ... ... Wei B, et al. Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 23: 3186-94. PMID 23628333 DOI: 10.1016/J.Bmcl.2013.04.001  0.35
2013 Staben ST, Ndubaku C, Blaquiere N, Belvin M, Bull RJ, Dudley D, Edgar K, Gray D, Heald R, Heffron TP, Jones GE, Jones M, Kolesnikov A, Lee L, Lesnick J, ... ... Wei B, et al. Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform. Bioorganic & Medicinal Chemistry Letters. 23: 2606-13. PMID 23540645 DOI: 10.1016/J.Bmcl.2013.02.102  0.326
2013 Staben ST, Blaquiere N, Tsui V, Kolesnikov A, Do S, Bradley EK, Dotson J, Goldsmith R, Heffron TP, Lesnick J, Lewis C, Murray J, Nonomiya J, Olivero AG, Pang J, ... ... Wei B, et al. Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 23: 897-901. PMID 23265894 DOI: 10.1016/J.Bmcl.2012.10.121  0.311
2012 Sutherlin DP, Baker S, Bisconte A, Blaney PM, Brown A, Chan BK, Chantry D, Castanedo G, DePledge P, Goldsmith P, Goldstein DM, Hancox T, Kaur J, Knowles D, Kondru R, ... ... Wei B, et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorganic & Medicinal Chemistry Letters. 22: 4296-302. PMID 22672799 DOI: 10.1016/J.Bmcl.2012.05.027  0.35
2012 Safina BS, Baker S, Baumgardner M, Blaney PM, Chan BK, Chen YH, Cartwright MW, Castanedo G, Chabot C, Cheguillaume AJ, Goldsmith P, Goldstein DM, Goyal B, Hancox T, Handa RK, ... ... Wei B, et al. Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition. Journal of Medicinal Chemistry. 55: 5887-900. PMID 22626259 DOI: 10.1021/Jm3003747  0.341
2012 Efremov IV, Vajdos FF, Borzilleri KA, Capetta S, Chen H, Dorff PH, Dutra JK, Goldstein SW, Mansour M, McColl A, Noell S, Oborski CE, O'Connell TN, O'Sullivan TJ, Pandit J, ... ... Wei B, et al. Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design. Journal of Medicinal Chemistry. 55: 9069-88. PMID 22468999 DOI: 10.1021/Jm201715D  0.409
2011 Heffron TP, Wei B, Olivero A, Staben ST, Tsui V, Do S, Dotson J, Folkes AJ, Goldsmith P, Goldsmith R, Gunzner J, Lesnick J, Lewis C, Mathieu S, Nonomiya J, et al. Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform. Journal of Medicinal Chemistry. 54: 7815-33. PMID 21985639 DOI: 10.1021/Jm2007084  0.324
2011 Sutherlin DP, Bao L, Berry M, Castanedo G, Chuckowree I, Dotson J, Folks A, Friedman L, Goldsmith R, Gunzner J, Heffron T, Lesnick J, Lewis C, Mathieu S, Murray J, ... ... Wei B, et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. Journal of Medicinal Chemistry. 54: 7579-87. PMID 21981714 DOI: 10.1021/Jm2009327  0.349
2011 Sutherlin DP, Belvin M, Bao L, Berry L, Berry M, Castanedo G, Edgar K, Folkes A, Friedman L, Heffron T, Patel S, Olivero A, Lesnick J, Lewis C, Marsters J, ... ... Wei B, et al. Abstract 2787: Discovery of GDC-0980, a selective PI3K/mTOR inhibitor in clinical trials Cancer Research. 71: 2787-2787. DOI: 10.1158/1538-7445.Am2011-2787  0.362
2004 Ferrari AM, Wei BQ, Costantino L, Shoichet BK. Soft docking and multiple receptor conformations in virtual screening. Journal of Medicinal Chemistry. 47: 5076-84. PMID 15456251 DOI: 10.1021/Jm049756P  0.506
2004 Wei BQ, Weaver LH, Ferrari AM, Matthews BW, Shoichet BK. Testing a flexible-receptor docking algorithm in a model binding site. Journal of Molecular Biology. 337: 1161-82. PMID 15046985 DOI: 10.1016/J.Jmb.2004.02.015  0.581
2003 Soelaiman S, Wei BQ, Bergson P, Lee YS, Shen Y, Mrksich M, Shoichet BK, Tang WJ. Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough Journal of Biological Chemistry. 278: 25990-25997. PMID 12676933 DOI: 10.1074/Jbc.M301232200  0.49
2002 Wei BQ, Baase WA, Weaver LH, Matthews BW, Shoichet BK. A model binding site for testing scoring functions in molecular docking. Journal of Molecular Biology. 322: 339-55. PMID 12217695 DOI: 10.1016/S0022-2836(02)00777-5  0.584
2002 Shoichet BK, McGovern SL, Wei B, Irwin JJ. Lead discovery using molecular docking. Current Opinion in Chemical Biology. 6: 439-46. PMID 12133718 DOI: 10.1016/S1367-5931(02)00339-3  0.674
2002 Irwin JJ, Lorber DM, McGovern SL, Wei B, Shoichet BK. Molecular docking and drug design 2002 International Conference On Computational Nanoscience and Nanotechnology - Iccn 2002. 50-51.  0.565
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