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Peter B. Sampson, Ph.D. - Publications

Affiliations: 
2000 University of Waterloo, Waterloo, ON, Canada 
Area:
interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Li SW, Liu Y, Sampson PB, Patel NK, Forrest BT, Edwards L, Laufer R, Feher M, Ban F, Awrey DE, Hodgson R, Beletskaya I, Mao G, Mason JM, Wei X, et al. Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy. Bioorganic & Medicinal Chemistry Letters. PMID 27592744 DOI: 10.1016/J.Bmcl.2016.08.063  0.36
2016 Liu Y, Laufer R, Patel NK, Ng G, Sampson PB, Li SW, Lang Y, Feher M, Brokx R, Beletskaya I, Hodgson R, Plotnikova O, Awrey DE, Qiu W, Chirgadze NY, et al. Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent. Acs Medicinal Chemistry Letters. 7: 671-5. PMID 27437075 DOI: 10.1021/Acsmedchemlett.5B00485  0.367
2015 Liu Y, Lang Y, Patel NK, Ng G, Laufer R, Li SW, Edwards L, Forrest B, Sampson PB, Feher M, Ban F, Awrey DE, Beletskaya I, Mao G, Hodgson R, et al. The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents. Journal of Medicinal Chemistry. 58: 3366-92. PMID 25763473 DOI: 10.1021/Jm501740A  0.375
2015 Sampson PB, Liu Y, Patel NK, Feher M, Forrest B, Li SW, Edwards L, Laufer R, Lang Y, Ban F, Awrey DE, Mao G, Plotnikova O, Leung G, Hodgson R, et al. The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. Journal of Medicinal Chemistry. 58: 130-46. PMID 24867403 DOI: 10.1021/Jm5005336  0.345
2013 Laufer R, Forrest B, Li SW, Liu Y, Sampson P, Edwards L, Lang Y, Awrey DE, Mao G, Plotnikova O, Leung G, Hodgson R, Beletskaya I, Mason JM, Luo X, et al. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. Journal of Medicinal Chemistry. 56: 6069-87. PMID 23829549 DOI: 10.1021/Jm400380M  0.372
2009 Sampson PB, Picard C, Handerson S, McGrath TE, Domagala M, Leeson A, Romanov V, Awrey DE, Thambipillai D, Bardouniotis E, Kaplan N, Berman JM, Pauls HW. Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI). Bioorganic & Medicinal Chemistry Letters. 19: 5355-8. PMID 19682901 DOI: 10.1016/J.Bmcl.2009.07.129  0.355
2009 Ramnauth J, Surman MD, Sampson PB, Forrest B, Wilson J, Freeman E, Manning DD, Martin F, Toro A, Domagala M, Awrey DE, Bardouniotis E, Kaplan N, Berman J, Pauls HW. 2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI. Bioorganic & Medicinal Chemistry Letters. 19: 5359-62. PMID 19682900 DOI: 10.1016/J.Bmcl.2009.07.094  0.382
2005 Vaughan MD, Sampson PB, Daub E, Honek JF. Investigation of bioisosteric effects on the interaction of substrates/ inhibitors with the methionyl-tRNA synthetase from Escherichia coli. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 1: 227-37. PMID 16787318 DOI: 10.2174/1573406053765477  0.649
2004 Richardson TI, Ornstein PL, Briner K, Fisher MJ, Backer RT, Biggers CK, Clay MP, Emmerson PJ, Hertel LW, Hsiung HM, Husain S, Kahl SD, Lee JA, Lindstrom TD, Martinelli MJ, ... ... Sampson PB, et al. Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. Journal of Medicinal Chemistry. 47: 744-55. PMID 14736255 DOI: 10.1021/Jm0304109  0.306
2003 Crepin T, Schmitt E, Mechulam Y, Sampson PB, Vaughan MD, Honek JF, Blanquet S. Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase. Journal of Molecular Biology. 332: 59-72. PMID 12946347 DOI: 10.1016/S0022-2836(03)00917-3  0.614
2002 Vaughan MD, Sampson PB, Honek JF. Methionine in and out of proteins: targets for drug design. Current Medicinal Chemistry. 9: 385-409. PMID 11860363 DOI: 10.2174/0929867023371102  0.628
2002 Steere JA, Sampson PB, Honek JF. Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase. Bioorganic & Medicinal Chemistry Letters. 12: 457-60. PMID 11814819 DOI: 10.1016/S0960-894X(01)00789-2  0.562
1999 Lowther WT, Zhang Y, Sampson PB, Honek JF, Matthews BW. Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry. 38: 14810-9. PMID 10555963 DOI: 10.1021/Bi991711G  0.588
1999 Sampson PB, Honek JF. Oxidative deprotection of diphenylmethylamines Organic Letters. 1: 1395-1397. DOI: 10.1021/Ol990956I  0.508
1998 Ly HD, Clugston SL, Sampson PB, Honek JF. Syntheses and kinetic evaluation of hydroxamate-based peptide inhibitors of glyoxalase I. Bioorganic & Medicinal Chemistry Letters. 8: 705-10. PMID 9871526 DOI: 10.1016/S0960-894X(98)00116-4  0.603
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