Michael J. Owens - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
neuropharmacology
Website:
http://www.psychiatry.emory.edu/faculty/owens_michael.html

193 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Thrivikraman KV, Kinkead B, Owens MJ, Rapaport MH, Plotsky PM. Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity and Cardiovascular Homeostasis in Male Rats. Neuroendocrinology. PMID 34649254 DOI: 10.1159/000520192  0.585
2020 Stehouwer JS, Birnbaum MS, Voll RJ, Owens MJ, Plott SJ, Bourke CH, Wassef MA, Kilts CD, Goodman MM. Erratum to "Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor" [Bioorg. Med. Chem. 23 (2015) 4286-4302]. Bioorganic & Medicinal Chemistry. 115660. PMID 32747078 DOI: 10.1016/j.bmc.2020.115660  0.75
2019 Kalin M, Cochran A, Newport DJ, Knight B, Morris N, Ritchie J, Owens M, Stowe Z. S58. Fetal Antidepressant Exposure and Outcomes Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.809  0.549
2018 Coplan JD, Lu D, El Sehamy AM, Tang C, Jackowski AP, Abdallah CG, Nemeroff CB, Owens MJ, Mathew SJ, Gorman JM. Early Life Stress Associated With Increased Striatal -Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates. Chronic Stress (Thousand Oaks, Calif.). 2. PMID 29963652  0.539
2018 Coplan JD, Rozenboym AV, Fulton SL, Panthangi V, Tang J, Thiramangalakdi L, Perera TD, Liu Y, Kamran H, Owens MJ, Nemeroff CB, Rosenblum LA, Kral JG, Salciccioli L, Lazar J. Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders. Neurobiology of Stress. 8: 202-210. PMID 29888314 DOI: 10.1016/j.ynstr.2017.01.001  0.554
2017 Adhikarla V, Dunlop BW, Jarkas N, Goodman M, Mayberg H, Owens MJ, Nye JA. Test-retest reliability of the SERT imaging agent [(11)C]HOMADAM in healthy humans. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28935840 DOI: 10.2967/Jnumed.117.196915  0.485
2017 Syed SA, Smith EL, Batuman O, Rosenblum LA, Owens MJ, Nemeroff CB, Coplan JD. Adult Glucocorticoid Receptor mRNA Expression Volatility in Response to an Acute Stressor and Juvenile CSF Corticotropin-Releasing Factor: A Pilot Neurodevelopmental Study. Neuroscience Letters. PMID 28330718 DOI: 10.1016/j.neulet.2017.03.017  0.595
2016 Neigh GN, Nemeth CL, Kelly SD, Hardy EE, Bourke C, Stowe ZN, Owens MJ. Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram. Physiology & Behavior. PMID 27422674 DOI: 10.1016/j.physbeh.2016.07.009  0.792
2015 Stehouwer JS, Bourke CH, Owens MJ, Voll RJ, Kilts CD, Goodman MM. Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors. Bioorganic & Medicinal Chemistry Letters. 25: 5111-4. PMID 26456805 DOI: 10.1016/j.bmcl.2015.10.010  0.747
2015 Stehouwer JS, Birnbaum MS, Voll RJ, Owens MJ, Plott SJ, Bourke CH, Wassef MA, Kilts CD, Goodman MM. Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor. Bioorganic & Medicinal Chemistry. PMID 26145817 DOI: 10.1016/j.bmc.2015.06.036  0.749
2015 Ehrlich DE, Neigh GN, Bourke CH, Nemeth CL, Hazra R, Ryan SJ, Rowson S, Jairam N, Sholar CA, Rainnie DG, Stowe ZN, Owens MJ. Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. Neuropharmacology. 97: 251-258. PMID 26032436 DOI: 10.1016/J.Neuropharm.2015.05.012  0.805
2014 Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, et al. Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene. Frontiers in Behavioral Neuroscience. 8: 342. PMID 25339875 DOI: 10.3389/Fnbeh.2014.00342  0.56
2014 Bourke CH, Stowe ZN, Owens MJ. Prenatal antidepressant exposure: clinical and preclinical findings. Pharmacological Reviews. 66: 435-65. PMID 24567054 DOI: 10.1124/pr.111.005207  0.756
2014 Chappell JC, Eisenhofer G, Owens MJ, Haber H, Lachno DR, Dean RA, Knadler MP, Nemeroff CB, Mitchell MI, Detke MJ, Iyengar S, Pangallo B, Lobo ED. Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects. Journal of Clinical Psychopharmacology. 34: 9-16. PMID 24346757 DOI: 10.1097/JCP.0000000000000061  0.547
2014 Bourke CH, Capello CF, Rogers SM, Yu ML, Boss-Williams KA, Weiss JM, Stowe ZN, Owens MJ. Erratum to: Prenatal exposure to escitalopram and/or stress in rats Psychopharmacology. 231: 4583-4583. DOI: 10.1007/s00213-014-3701-4  0.767
2013 Bourke CH, Stowe ZN, Neigh GN, Olson DE, Owens MJ. Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats. Neurotoxicology and Teratology. 39: 100-9. PMID 23906943 DOI: 10.1016/j.ntt.2013.07.008  0.798
2013 Thrivikraman KV, Kinkead B, Murray KE, Owens MJ. In vivo dialysis setup with a loop injection valve facilitates retrodialysis studies. Journal of Pharmacological and Toxicological Methods. 68: 217-24. PMID 23831608 DOI: 10.1016/j.vascn.2013.06.002  0.614
2013 Bourke CH, Capello CF, Rogers SM, Yu ML, Boss-Williams KA, Weiss JM, Stowe ZN, Owens MJ. Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. Psychopharmacology. 228: 231-41. PMID 23436130 DOI: 10.1007/s00213-013-3030-z  0.767
2013 Flandreau EI, Bourke CH, Ressler KJ, Vale WW, Nemeroff CB, Owens MJ. Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala. Psychoneuroendocrinology. 38: 1349-61. PMID 23267723 DOI: 10.1016/J.Psyneuen.2012.11.020  0.794
2012 Rye DB, Bliwise DL, Parker K, Trotti LM, Saini P, Fairley J, Freeman A, Garcia PS, Owens MJ, Ritchie JC, Jenkins A. Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science Translational Medicine. 4: 161ra151. PMID 23175709 DOI: 10.1126/Scitranslmed.3004685  0.481
2012 Dunlop BW, Binder EB, Cubells JF, Goodman MM, Kelley ME, Kinkead B, Kutner M, Nemeroff CB, Newport DJ, Owens MJ, Pace TW, Ritchie JC, Rivera VA, Westen D, Craighead WE, et al. Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial. Trials. 13: 106. PMID 22776534 DOI: 10.1186/1745-6215-13-106  0.778
2012 Coccaro EF, Lee R, Owens MJ, Kinkead B, Nemeroff CB. Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects. Biological Psychiatry. 72: 238-43. PMID 22449753 DOI: 10.1016/J.Biopsych.2012.02.023  0.703
2012 Flandreau EI, Ressler KJ, Owens MJ, Nemeroff CB. Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus. Psychoneuroendocrinology. 37: 27-38. PMID 21616602 DOI: 10.1016/J.Psyneuen.2011.04.014  0.801
2011 Hanson ND, Owens MJ, Nemeroff CB. Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2589-602. PMID 21937982 DOI: 10.1038/npp.2011.220  0.708
2011 Capello CF, Bourke CH, Ritchie JC, Stowe ZN, Newport DJ, Nemeroff A, Owens MJ. Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk. The Journal of Pharmacology and Experimental Therapeutics. 339: 275-85. PMID 21775476 DOI: 10.1124/jpet.111.183855  0.776
2011 Hanson ND, Owens MJ, Boss-Williams KA, Weiss JM, Nemeroff CB. Several stressors fail to reduce adult hippocampal neurogenesis. Psychoneuroendocrinology. 36: 1520-9. PMID 21600697 DOI: 10.1016/j.psyneuen.2011.04.006  0.71
2011 Coplan JD, Abdallah CG, Mathew SJ, Shungu DC, Mao X, Smith EL, Kaufman D, Gorman JM, Owens MJ, Nemeroff CB, Banerji MA, Rosenblum LA, Kral JG. Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. Physiology & Behavior. 103: 535-9. PMID 21459102 DOI: 10.1016/j.physbeh.2011.03.020  0.547
2011 Hanson ND, Nemeroff CB, Owens MJ. Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. The Journal of Pharmacology and Experimental Therapeutics. 337: 180-6. PMID 21220416 DOI: 10.1124/jpet.110.175372  0.712
2011 Bonne O, Gill JM, Luckenbaugh DA, Collins C, Owens MJ, Alesci S, Neumeister A, Yuan P, Kinkead B, Manji HK, Charney DS, Vythilingam M. Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine. The Journal of Clinical Psychiatry. 72: 1124-8. PMID 21208596 DOI: 10.4088/Jcp.09M05106Blu  0.656
2011 Gutman DA, Owens MJ, Thrivikraman KV, Nemeroff CB. Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in rats. Neuropharmacology. 60: 1135-41. PMID 20951149 DOI: 10.1016/j.neuropharm.2010.10.004  0.715
2011 Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study. Psychoneuroendocrinology. 36: 289-93. PMID 20692103 DOI: 10.1016/J.Psyneuen.2010.07.011  0.563
2010 Stehouwer JS, Daniel LM, Chen P, Voll RJ, Williams L, Plott SJ, Votaw JR, Owens MJ, Howell L, Goodman MM. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. Journal of Medicinal Chemistry. 53: 5549-57. PMID 20597489 DOI: 10.1021/Jm100269C  0.482
2010 Neigh GN, Owens MJ, Taylor WR, Nemeroff CB. Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1100-4. PMID 20372172 DOI: 10.1038/jcbfm.2010.46  0.701
2010 Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB. Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Archives of General Psychiatry. 67: 369-79. PMID 20368512 DOI: 10.1001/Archgenpsychiatry.2010.18  0.648
2010 Martin EI, Ressler KJ, Jasnow AM, Dabrowska J, Hazra R, Rainnie DG, Nemeroff CB, Owens MJ. A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biological Psychiatry. 67: 1212-6. PMID 20303068 DOI: 10.1016/J.Biopsych.2010.01.026  0.519
2010 Nye JA, Owens MJ, Dunlop BW, Jarkas N, Mayberg HS, Goodman MM. Test–retest reliability of the SERT imaging agent [11C]HOMADAM in healthy humans ☆ Neuroimage. 52. DOI: 10.1016/J.Neuroimage.2010.04.089  0.454
2009 Neigh GN, Karelina K, Zhang N, Glasper ER, Owens MJ, Plotsky PM, Nemeroff CB, Devries AC. Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1673-82. PMID 19553908 DOI: 10.1038/Jcbfm.2009.85  0.703
2009 Nemeroff CB, Owens MJ. The role of serotonin in the pathophysiology of depression: as important as ever. Clinical Chemistry. 55: 1578-9. PMID 19498050 DOI: 10.1373/clinchem.2009.123752  0.563
2009 Keen-Rhinehart E, Michopoulos V, Toufexis DJ, Martin EI, Nair H, Ressler KJ, Davis M, Owens MJ, Nemeroff CB, Wilson ME. Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. Molecular Psychiatry. 14: 37-50. PMID 18698320 DOI: 10.1038/Mp.2008.91  0.624
2009 Gutman DA, Coyer MJ, Boss-Williams KA, Owens MJ, Nemeroff CB, Weiss JM. Erratum to “Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test” [Psychoneuroendocrinology 33(8) (2008) 1093–1101] Psychoneuroendocrinology. 34: 630-631. DOI: 10.1016/j.psyneuen.2009.01.008  0.665
2008 Stehouwer JS, Jarkas N, Zeng F, Voll RJ, Williams L, Camp VM, Malveaux EJ, Votaw JR, Howell L, Owens MJ, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of Medicinal Chemistry. 51: 7788-99. PMID 19053782 DOI: 10.1021/jm800781a  0.411
2008 Gutman DA, Coyer MJ, Boss-Williams KA, Owens MJ, Nemeroff CB, Weiss JM. Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 33: 1093-101. PMID 18676086 DOI: 10.1016/j.psyneuen.2008.05.003  0.666
2008 Owens MJ, Krulewicz S, Simon JS, Sheehan DV, Thase ME, Carpenter DJ, Plott SJ, Nemeroff CB. Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 3201-12. PMID 18418363 DOI: 10.1038/npp.2008.47  0.55
2008 Kinkead B, Yan F, Owens MJ, Nemeroff CB. Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats. Psychoneuroendocrinology. 33: 178-87. PMID 18155361 DOI: 10.1016/j.psyneuen.2007.11.005  0.717
2008 Jarkas N, Voll RJ, Williams L, Votaw JR, Owens M, Goodman MM. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. Journal of Medicinal Chemistry. 51: 271-81. PMID 18085744 DOI: 10.1021/jm0707929  0.421
2008 Zeng F, Jarkas N, Stehouwer JS, Voll RJ, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorganic & Medicinal Chemistry. 16: 783-93. PMID 17983754 DOI: 10.1016/j.bmc.2007.10.025  0.627
2008 Carpenter LL, Bayat L, Moreno F, Kling MA, Price LH, Tyrka AR, Kinkead B, Owens MJ, Nemeroff CB. Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy. Psychiatry Research. 157: 123-9. PMID 17976740 DOI: 10.1016/J.Psychres.2007.04.016  0.722
2007 Plisson C, Stehouwer JS, Voll RJ, Howell L, Votaw JR, Owens MJ, Goodman MM. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. Journal of Medicinal Chemistry. 50: 4553-60. PMID 17705359 DOI: 10.1021/jm061303s  0.421
2007 Newport DJ, Calamaras MR, DeVane CL, Donovan J, Beach AJ, Winn S, Knight BT, Gibson BB, Viguera AC, Owens MJ, Nemeroff CB, Stowe ZN. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. The American Journal of Psychiatry. 164: 1214-20. PMID 17671284 DOI: 10.1176/appi.ajp.2007.06111886  0.653
2007 Skelton KH, Oren D, Gutman DA, Easterling K, Holtzman SG, Nemeroff CB, Owens MJ. The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal. European Journal of Pharmacology. 571: 17-24. PMID 17610870 DOI: 10.1016/j.ejphar.2007.05.041  0.818
2007 Zeng F, Stehouwer JS, Jarkas N, Voll RJ, Williams L, Camp VM, Votaw JR, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents. Bioorganic & Medicinal Chemistry Letters. 17: 3044-7. PMID 17446069 DOI: 10.1016/j.bmcl.2007.03.056  0.614
2007 Skelton KH, Gutman DA, Thrivikraman KV, Nemeroff CB, Owens MJ. The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. Psychopharmacology. 192: 385-96. PMID 17297634 DOI: 10.1007/s00213-007-0713-3  0.819
2007 McConathy J, Capello C, Jarkas N, Stowe ZN, Owens MJ. Preparation of antidepressants for use in preclinical research. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 10: 759-63. PMID 17201995 DOI: 10.1017/S1461145706007474  0.769
2006 Stehouwer JS, Jarkas N, Zeng F, Voll RJ, Williams L, Owens MJ, Votaw JR, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of Medicinal Chemistry. 49: 6760-7. PMID 17154506 DOI: 10.1021/Jm060641Q  0.479
2006 Gutman DA, Owens MJ. Serotonin and norepinephrine transporter binding profile of SSRIs. Essential Psychopharmacology. 7: 35-41. PMID 16989291  0.489
2006 Coplan JD, Smith EL, Altemus M, Mathew SJ, Perera T, Kral JG, Gorman JM, Owens MJ, Nemeroff CB, Rosenblum LA. Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations. Annals of the New York Academy of Sciences. 1071: 525-33. PMID 16891612 DOI: 10.1196/annals.1364.057  0.551
2006 DeVane CL, Stowe ZN, Donovan JL, Newport DJ, Pennell PB, Ritchie JC, Owens MJ, Wang JS. Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities. Journal of Psychopharmacology (Oxford, England). 20: 54-9. PMID 16785271 DOI: 10.1177/1359786806066054  0.648
2006 Zeng F, Jarkas N, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorganic & Medicinal Chemistry Letters. 16: 4661-3. PMID 16784855 DOI: 10.1016/j.bmcl.2006.05.098  0.612
2006 Geracioti TD, Carpenter LL, Owens MJ, Baker DG, Ekhator NN, Horn PS, Strawn JR, Sanacora G, Kinkead B, Price LH, Nemeroff CB. Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression. The American Journal of Psychiatry. 163: 637-43. PMID 16585438 DOI: 10.1176/Ajp.2006.163.4.637  0.72
2006 Kinkead B, Selz KA, Owens MJ, Mandell AJ. Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism. Journal of Neuroscience Methods. 151: 68-81. PMID 16423408 DOI: 10.1016/j.jneumeth.2005.07.015  0.701
2006 Loughhead AM, Fisher AD, Newport DJ, Ritchie JC, Owens MJ, DeVane CL, Stowe ZN. Antidepressants in amniotic fluid: another route of fetal exposure. The American Journal of Psychiatry. 163: 145-7. PMID 16390902 DOI: 10.1176/appi.ajp.163.1.145  0.647
2006 Loughhead AM, Stowe ZN, Newport DJ, Ritchie JC, DeVane CL, Owens MJ. Placental passage of tricyclic antidepressants. Biological Psychiatry. 59: 287-90. PMID 16271264 DOI: 10.1016/j.biopsych.2005.06.040  0.638
2006 Gutman DA, Gutman AR, Owens MJ, Nemeroff CB. Stress neurobiology and corticotropin-releasing factor Psychiatric Times. 23: 91-95.  0.643
2005 Cáceda R, Kinkead B, Owens MJ, Nemeroff CB. Virally mediated increased neurotensin 1 receptor in the nucleus accumbens decreases behavioral effects of mesolimbic system activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11748-56. PMID 16354933 DOI: 10.1523/JNEUROSCI.4282-05.2005  0.794
2005 Davidson J, Watkins L, Owens M, Krulewicz S, Connor K, Carpenter D, Krishnan R, Nemeroff C. Effects of paroxetine and venlafaxine XR on heart rate variability in depression Journal of Clinical Psychopharmacology. 25: 480-484. PMID 16160626 DOI: 10.1097/01.jcp.0000177547.28961.03  0.5
2005 Coplan JD, Altemus M, Mathew SJ, Smith EL, Sharf B, Coplan PM, Kral JG, Gorman JM, Owens MJ, Nemeroff CB, Rosenblum LA. Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. Cns Spectrums. 10: 530-6. PMID 16155510 DOI: 10.1017/S109285290001018X  0.542
2005 Stowe ZN, Landry JC, Tang Z, Owens MJ, Kinkead B, Nemeroff CB. The electrophysiological effects of neurotensin on spontaneously active neurons in the nucleus accumbens: an in vivo study. Synapse (New York, N.Y.). 58: 165-72. PMID 16108007 DOI: 10.1002/syn.20190  0.764
2005 McConathy J, Owens MJ, Kilts CD, Malveaux EJ, Votaw JR, Nemeroff CB, Goodman MM. Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents. Nuclear Medicine and Biology. 32: 593-605. PMID 16026706 DOI: 10.1016/j.nucmedbio.2005.04.012  0.75
2005 Jarkas N, Votaw JR, Voll RJ, Williams L, Camp VM, Owens MJ, Purselle DC, Bremner JD, Kilts CD, Nemeroff CB, Goodman MM. Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. Nuclear Medicine and Biology. 32: 211-24. PMID 15820756 DOI: 10.1016/j.nucmedbio.2004.11.007  0.637
2005 Garlow SJ, Boone E, Li W, Owens MJ, Nemeroff CB. Genetic analysis of the hypothalamic corticotropin-releasing factor system. Endocrinology. 146: 2362-8. PMID 15705776 DOI: 10.1210/en.2004-1450  0.708
2004 Skelton KH, Nemeroff CB, Owens MJ. Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9303-12. PMID 15496666 DOI: 10.1523/JNEUROSCI.1737-04.2004  0.809
2004 Tyrka AR, Carpenter LL, McDougle CJ, Kirwin PD, Owens MJ, Nemeroff CB, Strong DR, Price LH. Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults. Biological Psychiatry. 56: 531-4. PMID 15450791 DOI: 10.1016/J.Biopsych.2004.06.035  0.578
2004 Newport DJ, Owens MJ, Knight DL, Ragan K, Morgan N, Nemeroff CB, Stowe ZN. Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. Journal of Psychiatric Research. 38: 467-73. PMID 15380396 DOI: 10.1016/j.jpsychires.2004.01.011  0.671
2004 Binder EB, Kinkead B, Owens MJ, Nemeroff CB. Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 2200-7. PMID 15328528 DOI: 10.1038/sj.npp.1300546  0.762
2004 McConathy J, Owens MJ, Kilts CD, Malveaux EJ, Camp VM, Votaw JR, Nemeroff CB, Goodman MM. Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter. Nuclear Medicine and Biology. 31: 705-18. PMID 15246361 DOI: 10.1016/j.nucmedbio.2003.05.001  0.726
2004 Nemeroff CB, Owens MJ. Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis. Cns Spectrums. 9: 23-31. PMID 15181382 DOI: 10.1017/S1092852900025475  0.583
2004 Arborelius L, Hawks BW, Owens MJ, Plotsky PM, Nemeroff CB. Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation. Psychopharmacology. 176: 248-55. PMID 15173929 DOI: 10.1007/S00213-004-1883-X  0.78
2004 Selz KA, Mandell AJ, Shlesinger MF, Arcuragi V, Owens MJ. Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators. Biophysical Journal. 86: 1308-31. PMID 14990463 DOI: 10.1016/S0006-3495(04)74204-6  0.525
2004 Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biological Psychiatry. 55: 320-2. PMID 14744476 DOI: 10.1016/j.biopsych.2003.07.006  0.545
2004 Carpenter LL, Tyrka AR, McDougle CJ, Malison RT, Owens MJ, Nemeroff CB, Price LH. Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 777-84. PMID 14702025 DOI: 10.1038/Sj.Npp.1300375  0.589
2004 Owens M, Hanson N, Gutman D. S.19.05 Development of molecular targets for understanding and treating stress-related disorders European Neuropsychopharmacology. 14: S148-S149. DOI: 10.1016/S0924-977X(04)80060-9  0.519
2003 McConathy J, Owens MJ. Stereochemistry in Drug Action. Primary Care Companion to the Journal of Clinical Psychiatry. 5: 70-73. PMID 15156233 DOI: 10.4088/Pcc.V05N0202  0.581
2003 Owens MJ, Nemeroff CB. Pharmacology of valproate. Psychopharmacology Bulletin. 37: 17-24. PMID 14624230  0.483
2003 Nemeroff CB, Owens MJ. Neuropharmacology of paroxetine. Psychopharmacology Bulletin. 37: 8-18. PMID 14566196  0.521
2003 Mandell AJ, Selz KA, Owens MJ, Kinkead B, Shlesinger MF, Gutman DA, Arguragi V. Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: S98-107. PMID 12827150 DOI: 10.1038/sj.npp.1300134  0.751
2003 Newport DJ, Heim C, Owens MJ, Ritchie JC, Ramsey CH, Bonsall R, Miller AH, Nemeroff CB. Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 569-76. PMID 12629539 DOI: 10.1038/sj.npp.1300071  0.741
2003 Gilmor ML, Skelton KH, Nemeroff CB, Owens MJ. The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems. The Journal of Pharmacology and Experimental Therapeutics. 305: 434-9. PMID 12606697 DOI: 10.1124/jpet.102.045419  0.811
2003 Stowe ZN, Hostetter AL, Owens MJ, Ritchie JC, Sternberg K, Cohen LS, Nemeroff CB. The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. The Journal of Clinical Psychiatry. 64: 73-80. PMID 12590627 DOI: 10.4088/Jcp.V64N0114  0.714
2003 Gutman DA, Owens MJ, Skelton KH, Thrivikraman KV, Nemeroff CB. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. The Journal of Pharmacology and Experimental Therapeutics. 304: 874-80. PMID 12538845 DOI: 10.1124/jpet.102.042788  0.811
2003 Nemeroff CB, Owens MJ. Reply to 'Editorial policies on financial disclosure' Nature Neuroscience. 6: 1000-1001. DOI: 10.1038/NN1003-1000  0.488
2003 Watkins L, Davidson J, Connor K, Beebe K, Krulewicz S, Abraham K, Zhang W, Owens M, Nemeroff C. P.1.233 Effects of paroxetine and venlafaxine-XP on heart rate variability in depression European Neuropsychopharmacology. 13: S274. DOI: 10.1016/S0924-977X(03)91943-2  0.521
2003 Fitzgerald LZ, Chang L, Lee CK, Owens MJ, Mayer M, Naliboff BD, Nemeroff CB, Mayer EA. Elevated levels of central stress mediators in irritable bowel syndrome Gastroenterology. 124: A252. DOI: 10.1016/S0016-5085(03)81266-0  0.533
2002 Nemeroff CB, Owens MJ. Treatment of mood disorders. Nature Neuroscience. 5: 1068-70. PMID 12403988 DOI: 10.1038/nn943  0.538
2002 Gilmor ML, Owens MJ, Nemeroff CB. Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine. The American Journal of Psychiatry. 159: 1702-10. PMID 12359676 DOI: 10.1176/appi.ajp.159.10.1702  0.791
2002 Mathew SJ, Coplan JD, Smith EL, Scharf BA, Owens MJ, Nemeroff CB, Mann JJ, Gorman JM, Rosenblum LA. Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing. Stress (Amsterdam, Netherlands). 5: 185-93. PMID 12186681 DOI: 10.1080/1025389021000010521  0.517
2002 Rosenblum LA, Smith EL, Altemus M, Scharf BA, Owens MJ, Nemeroff CB, Gorman JM, Coplan JD. Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. Psychoneuroendocrinology. 27: 651-60. PMID 12084658 DOI: 10.1016/S0306-4530(01)00056-7  0.56
2002 Stout SC, Owens MJ, Nemeroff CB. Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment. The Journal of Pharmacology and Experimental Therapeutics. 300: 1085-92. PMID 11861819 DOI: 10.1124/Jpet.300.3.1085  0.798
2001 Owens MJ, Nemeroff CB. An old transmitter in a new millennium. Cns Spectrums. 6: 655. PMID 15520612 DOI: 10.1017/S1092852900001334  0.486
2001 O'Brien D, Skelton KH, Owens MJ, Nemeroff CB. Are CRF receptor antagonists potential antidepressants? Human Psychopharmacology. 16: 81-87. PMID 12404602 DOI: 10.1002/hup.187  0.812
2001 Binder EB, Kinkead B, Owens MJ, Nemeroff CB. The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. Biological Psychiatry. 50: 856-72. PMID 11743941 DOI: 10.1016/S0006-3223(01)01211-2  0.731
2001 Binder EB, Kinkead B, Owens MJ, Nemeroff CB. Neurotensin and dopamine interactions. Pharmacological Reviews. 53: 453-86. PMID 11734615  0.736
2001 Owens MJ, Knight DL, Nemeroff CB. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biological Psychiatry. 50: 345-50. PMID 11543737 DOI: 10.1016/S0006-3223(01)01145-3  0.548
2001 Coplan JD, Smith EL, Altemus M, Scharf BA, Owens MJ, Nemeroff CB, Gorman JM, Rosenblum LA. Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry. 50: 200-4. PMID 11513819 DOI: 10.1016/S0006-3223(01)01175-1  0.557
2001 Stout SC, Owens MJ, Lindsey KP, Knight DL, Nemeroff CB. Effects of sodium valproate on corticotropin-releasing factor systems in rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 624-31. PMID 11331142 DOI: 10.1016/S0893-133X(00)00243-8  0.792
2001 Martarello L, Kilts CD, Ely T, Owens MJ, Nemeroff CB, Camp M, Goodman MM. Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor. Nuclear Medicine and Biology. 28: 187-95. PMID 11295429 DOI: 10.1016/S0969-8051(00)00199-2  0.637
2001 Stout SC, Owens MJ, Nemeroff CB. Neurokinin(1) receptor antagonists as potential antidepressants. Annual Review of Pharmacology and Toxicology. 41: 877-906. PMID 11264480 DOI: 10.1146/Annurev.Pharmtox.41.1.877  0.763
2001 Binder EB, Kinkead B, Owens MJ, Kilts CD, Nemeroff CB. Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 601-8. PMID 11160439 DOI: 10.1523/Jneurosci.21-02-00601.2001  0.759
2001 Radke JM, Owens MJ, Nemeroff CB. The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis. European Journal of Pharmacology. 411: 129-134. PMID 11137867 DOI: 10.1016/S0014-2999(00)00912-2  0.563
2001 Wisner KL, Findling RL, Perel JM, Stowe ZN, Cohen LS, Ritchie JC, Owens MJ, Nemeroff CB. Paroxetine in breast milk [3] (multiple letters) American Journal of Psychiatry. 158: 144-145. PMID 11136654 DOI: 10.1176/appi.ajp.158.1.144  0.685
2001 STOWE ZN, COHEN LS, RITCHIE JC, OWENS MJ, NEMEROFF CB. Dr. Stowe and Colleagues Reply American Journal of Psychiatry. 158: 144-b-145. DOI: 10.1176/APPI.AJP.158.1.144-B  0.689
2001 Owens M, Gutman D. CRF1 receptor antagonists: Long term treatment and efficacy in animal models European Neuropsychopharmacology. 11: S179-S180. DOI: 10.1016/S0924-977X(01)80118-8  0.519
2001 O'Brien D, Skelton KH, Owens MJ, Nemeroff CB. Novel approaches to the treatment of depression by modulating the hypothalamic-pituitary-adrenal axis Human Psychopharmacology. 16: 89-93. DOI: 10.1002/hup.188  0.691
2001 Gutman DA, Owens MJ, Nemeroff CB. CRF receptor antagonists: A new approach to the treatment of depression Pharmaceutical News. 8: 18-25.  0.46
2000 Kinkead B, Owens MJ, Nemeroff CB. The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain. Brain Research. Developmental Brain Research. 124: 1-10. PMID 11113506 DOI: 10.1016/S0165-3806(00)00097-3  0.733
2000 Vythilingam M, Anderson GM, Owens MJ, Halaszynski TM, Bremner JD, Carpenter LL, Heninger GR, Nemeroff CB, Charney DS. Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone. The Journal of Clinical Endocrinology and Metabolism. 85: 4138-45. PMID 11095445 DOI: 10.1210/jcem.85.11.6968  0.584
2000 Skelton KH, Owens MJ, Nemeroff CB. The neurobiology of urocortin. Regulatory Peptides. 93: 85-92. PMID 11033056 DOI: 10.1016/S0167-0115(00)00180-4  0.795
2000 Kinkead B, Lorch SM, Owens MJ, Nemeroff CB. Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 295: 205-11. PMID 10991980  0.712
2000 Kinkead B, Shahid S, Owens MJ, Nemeroff CB. Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 295: 67-73. PMID 10991962  0.718
2000 Coplan JD, Smith EL, Trost RC, Scharf BA, Altemus M, Bjornson L, Owens MJ, Gorman JM, Nemeroff CB, Rosenblum LA. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research. 95: 93-102. PMID 10963795 DOI: 10.1016/S0165-1781(00)00173-6  0.583
2000 Skelton KH, Nemeroff CB, Owens MJ. A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research. Psychopharmacology. 151: 72-6. PMID 10958119 DOI: 10.1007/s002130000469  0.779
2000 Stout SC, Mortas P, Owens MJ, Nemeroff CB, Moreau J. Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats. European Journal of Pharmacology. 401: 39-46. PMID 10915835 DOI: 10.1016/S0014-2999(00)00412-X  0.804
2000 Arborelius L, Skelton KH, Thrivikraman KV, Plotsky PM, Schulz DW, Owens MJ. Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat. The Journal of Pharmacology and Experimental Therapeutics. 294: 588-97. PMID 10900236  0.771
2000 Owens MJ, Knight DL, Nemeroff CB. Paroxetine binding to the rat norepinephrine transporter in vivo. Biological Psychiatry. 47: 842-5. PMID 10812044 DOI: 10.1016/S0006-3223(99)00314-5  0.564
2000 Goodman MM, Kilts CD, Keil R, Shi B, Martarello L, Xing D, Votaw J, Ely TD, Lambert P, Owens MJ, Camp VM, Malveaux E, Hoffman JM. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear Medicine and Biology. 27: 1-12. PMID 10755640 DOI: 10.1016/S0969-8051(99)00080-3  0.489
2000 Xing D, Chen P, Keil R, Kilts CD, Shi B, Camp VM, Malveaux G, Ely T, Owens MJ, Votaw J, Davis M, Hoffman JM, BaKay RA, Subramanian T, Watts RL, et al. Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography. Journal of Medicinal Chemistry. 43: 639-48. PMID 10691690 DOI: 10.1021/Jm9902234  0.477
2000 Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ, Nemeroff CB. Paroxetine in human breast milk and nursing infants. The American Journal of Psychiatry. 157: 185-9. PMID 10671385 DOI: 10.1176/appi.ajp.157.2.185  0.708
2000 Skelton KH, Nemeroff CB, Knight DL, Owens MJ. Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1240-8. PMID 10648728 DOI: 10.1523/Jneurosci.20-03-01240.2000  0.805
2000 Gutman D, Owens M, Nemeroff C. Corticotropin-releasing factor antagonists as novel psychotherapeutics Drugs of the Future. 25: 923. DOI: 10.1358/DOF.2000.025.09.665577  0.662
2000 Martarello L, Kilts CD, Ely T, Owens MJ, Nemeroff CB, Goodman MM. Design, synthesis and evaluation of amino-anilino-pyramidines as potential spect ligands for the CRF1 receptor Psychoneuroendocrinology. 25: S37. DOI: 10.1016/S0306-4530(00)90130-6  0.63
2000 Skelton KH, Nemeroff CB, Owens MJ. Urocortin, the CRF2 receptor and effects of anxiolytic drugs Psychoneuroendocrinology. 25: S17. DOI: 10.1016/S0306-4530(00)90091-X  0.807
2000 Mussleman D, Marzec U, Owens M, Reemsnyder A, Goodkin R, Hanson S, Nemeroff C. 253. Platelet activation in treatment responders vs. nonresponders in patients with major depression Biological Psychiatry. 47: S77. DOI: 10.1016/S0006-3223(00)00517-5  0.533
2000 Nemeroff C, Owens M, Skelton K, Guttman D, Winslow J, Plotsky P. 210. CRF1 receptor antagonists as novel putative antidepressants and anxiolytics Biological Psychiatry. 47: S64. DOI: 10.1016/S0006-3223(00)00473-X  0.78
1999 Owens MJ, Nemeroff CB. Corticotropin-releasing factor antagonists in affective disorders. Expert Opinion On Investigational Drugs. 8: 1849-1858. PMID 11139829 DOI: 10.1517/13543784.8.11.1849  0.606
1999 Ehlers CL, Somes C, Li TK, Lumeng L, Kinkead B, Owens MJ, Nemeroff CB. Neurontensin studies in alcohol naive, preferring and non-preferring rats. Neuroscience. 93: 227-36. PMID 10430486 DOI: 10.1016/S0306-4522(99)00113-X  0.719
1999 Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. The Journal of Endocrinology. 160: 1-12. PMID 9854171 DOI: 10.1677/joe.0.1600001  0.803
1999 Owens MJ, Nemeroff CB. Corticotropin-Releasing Factor Antagonists Cns Drugs. 12: 85-92. DOI: 10.2165/00023210-199912020-00001  0.608
1998 Malison RT, Price LH, Berman R, van Dyck CH, Pelton GH, Carpenter L, Sanacora G, Owens MJ, Nemeroff CB, Rajeevan N, Baldwin RM, Seibyl JP, Innis RB, Charney DS. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biological Psychiatry. 44: 1090-8. PMID 9836013 DOI: 10.1016/S0006-3223(98)00272-8  0.553
1998 Owens MJ, Nemeroff CB. The serotonin transporter and depression. Depression and Anxiety. 8: 5-12. PMID 9809208 DOI: 10.1002/(SICI)1520-6394(1998)8:1+<5::AID-DA2>3.0.CO;2-I  0.532
1998 Radke JM, Owens MJ, Ritchie JC, Nemeroff CB. Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions. Proceedings of the National Academy of Sciences of the United States of America. 95: 11462-4. PMID 9736759 DOI: 10.1073/pnas.95.19.11462  0.664
1998 Plotsky PM, Owens MJ, Nemeroff CB. Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis. The Psychiatric Clinics of North America. 21: 293-307. PMID 9670227 DOI: 10.1016/S0193-953X(05)70006-X  0.599
1998 Mandell AJ, Owens MJ, Selz KA, Morgan WN, Shlesinger MF, Nemeroff CB. Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions. Biopolymers. 46: 89-101. PMID 9664843 DOI: 10.1002/(SICI)1097-0282(199808)46:2<89::AID-BIP4>3.0.CO;2-T  0.635
1998 Coplan JD, Trost RC, Owens MJ, Cooper TB, Gorman JM, Nemeroff CB, Rosenblum LA. Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. Archives of General Psychiatry. 55: 473-7. PMID 9596051 DOI: 10.1001/Archpsyc.55.5.473  0.562
1998 STOWE ZN, OWENS MJ. Drs. Stowe and Owens Reply American Journal of Psychiatry. 155: 1626af-1626. DOI: 10.1176/AJP.155.11.1626AF  0.549
1998 Nemeroff C, Owens M, Plotsky P. 265. The HPA axis and the pathophysiology of depression: The role of early adverse Biological Psychiatry. 43: S79-S80. DOI: 10.1016/S0006-3223(98)90713-2  0.551
1997 Pariante CM, Pearce BD, Pisell TL, Owens MJ, Miller AH. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Molecular Pharmacology. 52: 571-81. PMID 9380019 DOI: 10.1124/Mol.52.4.571  0.373
1997 Stowe ZN, Owens MJ, Landry JC, Kilts CD, Ely T, Llewellyn A, Nemeroff CB. Sertraline and desmethylsertraline in human breast milk and nursing infants. The American Journal of Psychiatry. 154: 1255-60. PMID 9286185 DOI: 10.1176/Ajp.154.9.1255  0.649
1997 Heim C, Owens MJ, Plotsky PM, Nemeroff CB. The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor. Annals of the New York Academy of Sciences. 821: 194-207. PMID 9238204 DOI: 10.1111/j.1749-6632.1997.tb48279.x  0.655
1997 Heim C, Owens MJ, Plotsky PM, Nemeroff CB. Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder. Psychopharmacology Bulletin. 33: 185-92. PMID 9230630  0.654
1997 Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. The American Journal of Psychiatry. 154: 624-9. PMID 9137116 DOI: 10.1176/Ajp.154.5.624  0.515
1997 Behan DP, Khongsaly O, Owens MJ, Chung HD, Nemeroff CB, De Souza EB. Corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), and CRF/CRF-BP complex in Alzheimer's disease and control postmortem human brain. Journal of Neurochemistry. 68: 2053-60. PMID 9109532 DOI: 10.1046/J.1471-4159.1997.68052053.X  0.558
1997 Heit S, Owens MJ, Plotsky P, Nemeroff CB. ■ REVIEW : Corticotropin-releasing Factor, Stress, and Depression The Neuroscientist. 3: 186-194. DOI: 10.1177/107385849700300312  0.604
1997 Nemeroff C, Owens M, Plotsky P. S.15.05 The HPA axis and the pathophysiology of depression: The role of early adverse experience European Neuropsychopharmacology. 7: S109. DOI: 10.1016/S0924-977X(97)88411-8  0.548
1997 Stowe ZN, Llewellyn AM, Strader JR, Landry JC, Owens MJ, Ritchie J, Kilts CD, Nemeroff CB. S.15.04 Identification and treatment of postpartum depression European Neuropsychopharmacology. 7. DOI: 10.1016/S0924-977X(97)88410-6  0.663
1996 Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, Gorman JM, Nemeroff CB. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proceedings of the National Academy of Sciences of the United States of America. 93: 1619-23. PMID 8643680 DOI: 10.1073/Pnas.93.4.1619  0.591
1996 Ladd CO, Owens MJ, Nemeroff CB. Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. Endocrinology. 137: 1212-8. PMID 8625891 DOI: 10.1210/endo.137.4.8625891  0.817
1996 Hartline KM, Owens MJ, Nemeroff CB. Postmortem and cerebrospinal fluid studies of corticotropin-releasing factor in humans. Annals of the New York Academy of Sciences. 780: 96-105. PMID 8602742 DOI: 10.1111/J.1749-6632.1996.Tb15114.X  0.533
1995 See RE, Lynch AM, Aravagiri M, Nemeroff CB, Owens MJ. Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in rats. Brain Research. 704: 202-9. PMID 8788915 DOI: 10.1016/0006-8993(95)01114-5  0.556
1995 Owens MJ, Mulchahey JJ, Kasckow JW, Plotsky PM, Nemeroff CB. Exposure to an antisense oligonucleotide decreases corticotropin-releasing factor receptor binding in rat pituitary cultures. Journal of Neurochemistry. 64: 2358-61. PMID 7722522 DOI: 10.1046/J.1471-4159.1995.64052358.X  0.6
1995 Kinkead B, Owens MJ, Nemeroff CB. Ontogeny of the effect of antipsychotic drug treatment on neurotensin concentrations in the rat brain. Synapse (New York, N.Y.). 20: 244-8. PMID 7570356 DOI: 10.1002/syn.890200308  0.736
1995 Kasckow JW, Han JH, Parkes DG, Mulchahey JJ, Owens MJ, Risby ED, Fisher J, Nemeroff CB. Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones- BE(2)-M17 and BE(2)-C. Journal of Neuroendocrinology. 7: 461-6. PMID 7550293 DOI: 10.1111/J.1365-2826.1995.Tb00782.X  0.552
1995 Owens MJ, Ieni JR, Knight DL, Winders K, Nemeroff CB. The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life Sciences. 57: PL373-80. PMID 7475971 DOI: 10.1016/0024-3205(95)02222-5  0.551
1995 Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Cooper T, Gorman JM, Nemeroff CB. P-5-2 Behavioral, monoaminergic, neuroendecrine and neuropeptidergic alterations in grown nonhuman primates exposed to unpredictable early rearing: relevance to human anxiety European Neuropsychopharmacology. 5: 353. DOI: 10.1016/0924-977X(95)90606-E  0.535
1995 Nemeroff C, Stout S, Owens M. S-29-3 Stress peptides and HPA axis reactivity in depression European Neuropsychopharmacology. 5: 242-243. DOI: 10.1016/0924-977X(95)90296-P  0.757
1995 Han J, Kasckow J, Parkes D, Owens M, Stipetic M, Breitman D, Kazanjian H, Nemeroff C. Regulation of CRF in BE (2)-M17 and BE (2)-C neuroblastoma cell lines Biological Psychiatry. 37: 647. DOI: 10.1016/0006-3223(95)94607-X  0.5
1995 Stout SC, Owens MJ. Biological basis of brain function and disease. A. Frazer, P.B. Molinoff, A. Winokur, eds. Raven Press, New York, 1994. 459 pp. softcover, $39.00 (or $69.00 hardcover) Depression. 3: 264-266. DOI: 10.1002/Depr.3050030509  0.673
1994 Kasckow JW, Owens MJ, Stipetic MD, Han JH, Nemeroff CB. Corticotropin-releasing factor is secreted in the BE(2)-C neuroblastoma cell and is responsive to forskolin. Life Sciences. 54: 1825-9. PMID 8196496 DOI: 10.1016/0024-3205(94)90121-X  0.681
1994 Kasckow JW, Parkes DG, Owens MJ, Stipetic MD, Han JH, Nemeroff CB, Vale WW. The BE (2)-M17 neuroblastoma cell line synthesizes and secretes corticotropin-releasing factor. Brain Research. 654: 159-62. PMID 7982090 DOI: 10.1016/0006-8993(94)91583-0  0.712
1994 Kasckow JW, Mulcahey JJ, Han JH, Owens MJ, Stipetic MD, Breitman D, Nemeroff CB. Interleukin-1 alpha induces corticotropin-releasing factor secretion and synthesis from NPLC-KC cells through various second messenger pathways. Synapse (New York, N.Y.). 18: 354-8. PMID 7886628 DOI: 10.1002/syn.890180411  0.653
1994 Weiss JM, Stout JC, Aaron MF, Quan N, Owens MJ, Butler PD, Nemeroff CB. Depression and anxiety: role of the locus coeruleus and corticotropin-releasing factor. Brain Research Bulletin. 35: 561-72. PMID 7859114 DOI: 10.1016/0361-9230(94)90170-8  0.71
1994 Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical Chemistry. 40: 288-95. PMID 7508830 DOI: 10.1093/Clinchem/40.2.288  0.565
1994 Nemeroff C, Owens M, Owens C, Ehlers C, Robbins T, Levine S. The neurobiological consequences of early traumatic experiences: focus on corticotropin-releasing factor European Neuropsychopharmacology. 4: 255-256. DOI: 10.1016/0924-977X(94)90077-9  0.482
1994 Kasckow J, Owens M, Han J, Stipetic M, Nemeroff C. The BE(2)-C cell secretes corticotropin-releasing factor and responds to forskolin Biological Psychiatry. 35: 663. DOI: 10.1016/0006-3223(94)90833-8  0.531
1993 Koegler-Muly SM, Owens MJ, Ervin GN, Kilts CD, Nemeroff CB. Potential corticotropin-releasing factor pathways in the rat brain as determined by bilateral electrolytic lesions of the central amygdaloid nucleus and the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 5: 95-8. PMID 8485547 DOI: 10.1111/J.1365-2826.1993.Tb00367.X  0.716
1993 Ehlers CL, Kaneko WM, Owens MJ, Nemeroff CB. Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats. Biological Psychiatry. 33: 358-66. PMID 8471694 DOI: 10.1016/0006-3223(93)90325-8  0.552
1993 Pihoker C, Owens MJ, Kuhn CM, Schanberg SM, Nemeroff CB. Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. Psychoneuroendocrinology. 18: 485-93. PMID 8265736 DOI: 10.1016/0306-4530(93)90042-J  0.618
1993 Owens MJ, Vargas MA, Nemeroff CB. The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: implications for a role for CRF in the pathogenesis of anxiety disorders. Journal of Psychiatric Research. 27: 209-20. PMID 8145178 DOI: 10.1016/0022-3956(93)90029-2  0.625
1993 Owens MJ, Dole KC, Knight DL, Nemeroff CB. Preclinical evaluation of the putative antidepressant nefazodone Depression. 1: 315-323. DOI: 10.1002/DEPR.3050010606  0.585
1992 Vargas MA, Bissette G, Owens MJ, Ehlers CL, Nemeroff CB. Effects of chronic ethanol and benzodiazepine treatment and withdrawal on corticotropin-releasing factor neural systems. Annals of the New York Academy of Sciences. 654: 145-52. PMID 1632579 DOI: 10.1111/J.1749-6632.1992.Tb25963.X  0.539
1992 Ehlers CL, Chaplin RI, Wall TL, Lumeng L, Li TK, Owens MJ, Nemeroff CB. Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats. Psychopharmacology. 106: 359-64. PMID 1570383 DOI: 10.1007/Bf02245418  0.528
1992 Owens MJ, Ritchie JC, Nemeroff CB. 5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Brain Research. 573: 353-5. PMID 1504771 DOI: 10.1016/0006-8993(92)90788-B  0.627
1992 Ritchie JC, Owens MJ, Mayer H, Watson JT, Kilts C, Carroll BJ. Preliminary studies of 6 beta-hydroxydexamethasone and its importance in the DST. Biological Psychiatry. 32: 825-33. PMID 1450296 DOI: 10.1016/0006-3223(92)90086-F  0.444
1992 Owens MJ, Nemeroff CB. Stress, corticotropin-releasing factor neurons, and the actions of benzodiazepines. Clinical Neuropharmacology. 15: 155A-156A. PMID 1354023 DOI: 10.1097/00002826-199201001-00083  0.562
1992 Nemeroff C, Owens M. Serotonin antagonists as antipsychotic drugs European Neuropsychopharmacology. 2: 287. DOI: 10.1016/0924-977X(92)90119-S  0.529
1991 Cain ST, Owens MJ, Nemeroff CB. Subcellular distribution of corticotropin-releasing-factor-like immunoreactivity in rat central nervous system. Neuroendocrinology. 54: 36-41. PMID 1922675 DOI: 10.1159/000125848  0.5
1991 Owens MJ, Overstreet DH, Knight DL, Rezvani AH, Ritchie JC, Bissette G, Janowsky DS, Nemeroff CB. Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 4: 87-93. PMID 1851013  0.661
1991 Owens MJ, Knight DL, Ritchie JC, Nemeroff CB. The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration. The Journal of Pharmacology and Experimental Therapeutics. 256: 795-800. PMID 1847213  0.667
1991 Owens MJ, Knight DL, Ritchie JC, Nemeroff CB. The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neurons in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 256: 787-94. PMID 1847212  0.676
1991 Appel NM, Owens MJ, Culp S, Zaczek R, Contrera JF, Bissette G, Nemeroff CB, De Souza EB. Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats. Endocrinology. 128: 3237-46. PMID 1645265 DOI: 10.1210/endo-128-6-3237  0.544
1990 Owens MJ, Bartolome J, Schanberg SM, Nemeroff CB. Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone. Neuroendocrinology. 52: 626-31. PMID 2126613 DOI: 10.1159/000125655  0.539
1990 Owens MJ, Edwards E, Nemeroff CB. Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain. European Journal of Pharmacology. 190: 113-22. PMID 1963847 DOI: 10.1016/0014-2999(90)94118-H  0.578
1990 Nemeroff CB, Weiss JM, Bissette G, Owens MJ. Evidence for a role for corticotropin-releasing factor in the pathogenesis of anxiety disorders and in the action of triazolobenzodiazepines Journal of Psychiatric Research. 24: 90-91. DOI: 10.1016/0022-3956(90)90103-W  0.499
1989 Owens MJ, Bissette G, Nemeroff CB. Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain. Synapse (New York, N.Y.). 4: 196-202. PMID 2575286 DOI: 10.1002/syn.890040304  0.587
1988 Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Archives of General Psychiatry. 45: 577-9. PMID 2837159 DOI: 10.1001/archpsyc.1988.01800300075009  0.526
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