Aurnab Ghose - Related publications

Affiliations: 
IISER Pune, Pune, Maharashtra, India 
Area:
Development and organisation of neural circuits
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 CB Hanna, D Mudaliar, K John, CL Allen, L Sun, JE Hawkinson, Schönbrunn E, Georg GI, Jensen JT. Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis Biology of Reproduction. 103. PMID 32667031 DOI: 10.1093/biolre/ioaa097   
2020 Hanna CB, Mudaliar D, John K, Allen CL, Sun L, Hawkinson JE, Schönbrunn E, Georg GI, Jensen JT. Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis Biology of Reproduction. 103. PMID 32667031 DOI: 10.1093/biolre/ioaa097   
2020 Lacey BM, Xu Z, Chai X, Laskey J, Fradera X, Mittal P, Mishra S, Piesvaux J, Saradjian P, Shaffer L, Vassileva G, Gerdt C, Wang Y, Ferguson H, Smith DM, et al. Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors. Slas Discovery : Advancing Life Sciences R & D. 2472555220952071. PMID 32844715 DOI: 10.1177/2472555220952071   
2020 Zhang Y, Zhang TJ, Tu S, Zhang ZH, Meng FH. Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations. Molecules (Basel, Switzerland). 25. PMID 32911607 DOI: 10.3390/molecules25184094   
2020 Du Y, Wang R. Revealing the unbinding kinetics and mechanism of Type I and Type II protein kinase inhibitors by local-scaled molecular dynamics simulations. Journal of Chemical Theory and Computation. PMID 32841004 DOI: 10.1021/acs.jctc.0c00342   
2020 Yang X, Wu D, Yuan S. Tyrosine Kinase Inhibitors in the Combination Therapy of HER2 Positive Breast Cancer. Technology in Cancer Research & Treatment. 19: 1533033820962140. PMID 33034269 DOI: 10.1177/1533033820962140   
2020 Fienberg S, Eyermann CJ, Arendse L, Basarab GS, McPhail J, Burke JE, Chibale K. Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-kinase Inhibitors. Acs Infectious Diseases. PMID 32966036 DOI: 10.1021/acsinfecdis.0c00566   
2020 Zeytün E, Altıntop MD, Sever B, Özdemir A, Ellakwa DE, Ocak Z, Ciftci HI, Otsuka M, Fujita M, Radwan MO. A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors. Anti-Cancer Agents in Medicinal Chemistry. PMID 32838725 DOI: 10.2174/1871520620666200824100408   
2020 Wang Z, Shi J, Zhu X, Zhao W, Gong Y, Hao X, Hou Y, Liu Y, Ding S, Liu J, Chen Y. Design, synthesis and biological evaluation of novel 4-phenoxypyridine based 3-oxo-3,4-dihydroquinoxaline-2-carboxamide derivatives as potential c-Met kinase inhibitors. Bioorganic Chemistry. 105: 104371. PMID 33075664 DOI: 10.1016/j.bioorg.2020.104371   
2020 Colella B, Colardo M, Iannone G, Contadini C, Saiz-Ladera C, Fuoco C, Barilà D, Velasco G, Segatto M, Di Bartolomeo S. mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells. Cancers. 12. PMID 32823532 DOI: 10.3390/cancers12082266   
2020 Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Molecular Systems Biology. 16: e9518. PMID 33073539 DOI: 10.15252/msb.20209518   
2020 Shapira T, Rankine-Wilson L, Chao JD, Pichler V, Rens C, Pfeifer T, Av-Gay Y. High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against . Frontiers in Microbiology. 11: 553962. PMID 33042061 DOI: 10.3389/fmicb.2020.553962   
2020 Laufkötter O, Laufer S, Bajorath J. Kinase inhibitor data set for systematic analysis of representative kinases across the human kinome. Data in Brief. 32: 106189. PMID 32904416 DOI: 10.1016/j.dib.2020.106189   
2020 Wang B, Zhang W, Liu X, Zou F, Wang J, Liu Q, Wang A, Hu Z, Chen Y, Qi S, Jiang Z, Chen C, Hu C, Wang L, Wang W, et al. Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants. European Journal of Medicinal Chemistry. 207: 112744. PMID 32949955 DOI: 10.1016/j.ejmech.2020.112744   
2020 Pierotti CL, Tanzer MC, Jacobsen AV, Hildebrand JM, Garnier JM, Sharma P, Lucet IS, Cowan AD, Kersten WJ, Luo MX, Liang LY, Fitzgibbon C, Garnish SE, Hempel A, Nachbur U, et al. Potent inhibition of Necroptosis by simultaneously targeting multiple effectors of the pathway. Acs Chemical Biology. PMID 32902249 DOI: 10.1021/acschembio.0c00482   
2020 Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, Duez J, Fant X, Bach S, Marie D, Place M, Ben Salah S, Chartier A, Berteina-Raboin S, Chaikuad A, et al. Design of new disubstituted imidazo[1,2-]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1840-1853. PMID 33040634 DOI: 10.1080/14756366.2020.1825408   
2020 Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND. Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells. Biomolecules & Therapeutics. PMID 33073770 DOI: 10.4062/biomolther.2020.153   
2020 Mittal S, Kamath A, Joseph AM, Rajala MS. PLCγ1‑dependent invasion and migration of cells expressing NSCLC‑associated EGFR mutants. International Journal of Oncology. PMID 32945365 DOI: 10.3892/ijo.2020.5112   
2020 Xie T, Saleh T, Rossi P, Kalodimos CG. Conformational states dynamically populated by a kinase determine its function. Science (New York, N.Y.). PMID 33004676 DOI: 10.1126/science.abc2754   
2020 Amraei R, Alwani T, Ho RX, Aryan Z, Wang S, Rahimi N. Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy. The Journal of Biological Chemistry. PMID 32978258 DOI: 10.1074/jbc.RA120.014790   
2020 Halkowycz P, Grimshaw CE, Keung W, Tanis P, Proffitt C, Peacock K, de Jong R, Sabat M, Banerjee U, Ermolieff J. Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times. Slas Discovery : Advancing Life Sciences R & D. 2472555220964450. PMID 33084478 DOI: 10.1177/2472555220964450   
2020 Halkowycz P, Grimshaw CE, Keung W, Tanis P, Proffitt C, Peacock K, de Jong R, Sabat M, Banerjee U, Ermolieff J. Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times. Slas Discovery : Advancing Life Sciences R & D. 2472555220964450. PMID 33084478 DOI: 10.1177/2472555220964450   
2020 Jeong H, Park S, Kim SY, Cho SH, Jeong MS, Kim SR, Seo JB, Kim SH, Kim KN. 1-Cinnamoyltrichilinin from Causes Apoptosis through the p38 MAPK Pathway in HL-60 Human Leukemia Cells. International Journal of Molecular Sciences. 21. PMID 33053881 DOI: 10.3390/ijms21207506   
2020 Kang SJ, Lee JW, Song J, Park J, Choi J, Suh KH, Min KH. Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1928-1936. PMID 33086897 DOI: 10.1080/14756366.2020.1833876   
2020 Dai C, Shen L, Jin W, Lv B, Liu P, Wang X, Yin Y, Fu Y, Liang L, Ma Z, Zhang X, Wang Y, Xu D, Chen Z. Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicology and Applied Pharmacology. 115273. PMID 33035574 DOI: 10.1016/j.taap.2020.115273   
2020 Tran T, Mitra J, Ha T, Kavran JM. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling. The Journal of Biological Chemistry. PMID 32994222 DOI: 10.1074/jbc.RA120.015723   
2020 Tamir TY, Drewry DH, Wells C, Major MB, Axtman AD. PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor. Scientific Reports. 10: 15826. PMID 32985588 DOI: 10.1038/s41598-020-72869-9   
2020 Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M. Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers. Cancers. 12. PMID 33003386 DOI: 10.3390/cancers12102795   
2020 Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M. Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers. Cancers. 12. PMID 33003386 DOI: 10.3390/cancers12102795   
2020 Liu QQ, Zeng XL, Guan YL, Lu JX, Tu K, Liu FY. Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met. Journal of Zhejiang University. Science. B. 21: 779-795. PMID 33043644 DOI: 10.1631/jzus.B2000190   
2020 Kumar S, Singh SK, Rana B, Rana A. The regulatory function of mixed lineage kinase 3 in tumor and host immunity. Pharmacology & Therapeutics. 107704. PMID 33045253 DOI: 10.1016/j.pharmthera.2020.107704   
2020 Peyressatre M, Arama DP, Laure A, González-Vera JA, Pellerano M, Masurier N, Lisowski V, Morris MC. Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation. Frontiers in Chemistry. 8: 691. PMID 32974274 DOI: 10.3389/fchem.2020.00691   
2020 He P, Mann-Collura O, Fling J, Edara N, Hetz R, Razzaque MS. High phosphate actively induces cytotoxicity by rewiring pro-survival and pro-apoptotic signaling networks in HEK293 and HeLa cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32892444 DOI: 10.1096/fj.202000799RR   
2020 van Beijnum JR, Weiss A, Berndsen RH, Wong TJ, Reckman LC, Piersma SR, Zoetemelk M, de Haas R, Dormond O, Bex A, Henneman AA, Jimenez CR, Griffioen AW, Nowak-Sliwinska P. Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment. Cancers. 12. PMID 32967224 DOI: 10.3390/cancers12092697   
2020 Kang BW, Chau I. Molecular target: pan-AKT in gastric cancer. Esmo Open. 5. PMID 32948630 DOI: 10.1136/esmoopen-2020-000728   
2020 Jha V, Macchia M, Tuccinardi T, Poli G. Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors. Cancers. 12. PMID 32824733 DOI: 10.3390/cancers12082327   
2020 Kesar S, Paliwal S, Mishra P, Madan K, Chauhan M, Chauhan N, Verma K, Sharma S. Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity. Acs Medicinal Chemistry Letters. 11: 1694-1703. PMID 32944136 DOI: 10.1021/acsmedchemlett.0c00126   
2020 Liu R, Chen Y, Liu G, Li C, Song Y, Cao Z, Li W, Hu J, Lu C, Liu Y. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death & Disease. 11: 797. PMID 32973135 DOI: 10.1038/s41419-020-02998-6   
2020 Fang CY, Lai TC, Hsiao M, Chang YC. The Diverse Roles of TAO Kinases in Health and Diseases. International Journal of Molecular Sciences. 21. PMID 33050415 DOI: 10.3390/ijms21207463   
2020 Yang C, Sheng Y, Shi X, Liu Y, He Y, Du Y, Zhang G, Gao F. CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor. Cell Death & Disease. 11: 831. PMID 33024087 DOI: 10.1038/s41419-020-03037-0   
2020 Hermawati E, Ellita SD, Juliawaty LD, Hakim EH, Syah YM, Ishikawa H. Epoxyquinophomopsins A and B from endophytic fungus Phomopsis sp. and their activity against tyrosine kinase. Journal of Natural Medicines. PMID 33030695 DOI: 10.1007/s11418-020-01454-1   
2020 Shaaya M, Fauser J, Zhurikhina A, Conage-Pough JE, Huyot V, Brennan M, Flower CT, Matsche J, Khan S, Natarajan V, Rehman J, Kota P, White FM, Tsygankov D, Karginov AV. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife. 9. PMID 32965214 DOI: 10.7554/eLife.60647   
2020 Spengler K, Zibrova D, Woods A, Langendorf CG, Scott JW, Carling D, Heller R. Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495. The Biochemical Journal. PMID 32869834 DOI: 10.1042/BCJ20200555   
2020 Zhang M, Jang H, Nussinov R. Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases. Journal of Molecular Biology. PMID 32918948 DOI: 10.1016/j.jmb.2020.09.002   
2020 Chen Y, Zhou X. Research progress of mTOR inhibitors. European Journal of Medicinal Chemistry. 208: 112820. PMID 32966896 DOI: 10.1016/j.ejmech.2020.112820   
2020 Thompson PA, Eam B, Young NP, Fish S, Chen J, Barrera M, Howard H, Sung E, Parra A, Staunton J, Chiang GG, Gerson-Gurwitz A, Wegerski CJ, Nevarez A, Clarine J, et al. Targeting oncogene mRNA translation in B cell malignancies with eFT226, a potent and selective inhibitor of eIF4A1. Molecular Cancer Therapeutics. PMID 33037136 DOI: 10.1158/1535-7163.MCT-19-0973   
2020 Wang Q, Zhang Y, Zhu J, Zheng H, Chen S, Chen L, Yang HS. IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas. Signal Transduction and Targeted Therapy. 5: 153. PMID 32843616 DOI: 10.1038/s41392-020-0204-0   
2020 Laufkötter O, Laufer S, Bajorath J. Identifying representative kinases for inhibitor evaluation via systematic analysis of compound-based target relationships. European Journal of Medicinal Chemistry. 204: 112641. PMID 32745818 DOI: 10.1016/j.ejmech.2020.112641   
2020 Hu B, Zhang Y, Deng T, Gu J, Liu J, Yang H, Xu Y, Yan Y, Yang F, Zhang H, Jin Y, Zhou J. PDPK1 regulates autophagosome biogenesis by binding to PIK3C3. Autophagy. PMID 32876514 DOI: 10.1080/15548627.2020.1817279   
2020 LaMarche MJ, Acker MG, Argintaru A, Bauer D, Boisclair J, Chan H, Chen C, Chen YP, Chen Z, Deng Z, Doré M, Dunstan D, Fan J, Fekkes P, Firestone B, et al. Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 32910655 DOI: 10.1021/acs.jmedchem.0c01170