| Year |
Citation |
Score |
| 2020 |
Terriente-Felix A, Wilson EL, Whitworth AJ. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. Plos Genetics. 16: e1008844. PMID 33085661 DOI: 10.1371/journal.pgen.1008844 |
0.404 |
|
| 2020 |
Lee JJ, Andreazza S, Whitworth AJ. The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models. Scientific Reports. 10: 2693. PMID 32060339 DOI: 10.1038/s41598-020-59647-3 |
0.429 |
|
| 2020 |
De Lazzari F, Sandrelli F, Whitworth AJ, Bisaglia M. Antioxidant Therapy in Parkinson's Disease: Insights from . Antioxidants (Basel, Switzerland). 9. PMID 31936094 DOI: 10.3390/antiox9010052 |
0.311 |
|
| 2019 |
Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, ... Whitworth AJ, et al. Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nature Communications. 10: 3280. PMID 31337756 DOI: 10.1038/S41467-019-10857-Y |
0.68 |
|
| 2019 |
von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, et al. Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. Life Science Alliance. 2. PMID 30988163 DOI: 10.26508/lsa.201900392 |
0.384 |
|
| 2018 |
Lovero D, Giordano L, Marsano RM, Sanchez-Martinez A, Boukhatmi H, Drechsler M, Oliva M, Whitworth AJ, Porcelli D, Caggese C. Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. Plos One. 13: e0201811. PMID 30096161 DOI: 10.1371/journal.pone.0201811 |
0.413 |
|
| 2018 |
Schöndorf DC, Ivanyuk D, Baden P, Sanchez-Martinez A, De Cicco S, Yu C, Giunta I, Schwarz LK, Di Napoli G, Panagiotakopoulou V, Nestel S, Keatinge M, Pruszak J, Bandmann O, Heimrich B, ... ... Whitworth AJ, et al. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. Cell Reports. 23: 2976-2988. PMID 29874584 DOI: 10.1016/J.Celrep.2018.05.009 |
0.405 |
|
| 2018 |
Biosa A, Sanchez-Martinez A, Filograna R, Terriente-Felix A, Alam SM, Beltramini M, Bubacco L, Bisaglia M, Whitworth AJ. Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss. Human Molecular Genetics. PMID 29529199 DOI: 10.1093/Hmg/Ddy069 |
0.41 |
|
| 2018 |
Lee JJ, Sanchez-Martinez A, Zarate AM, Benincá C, Mayor U, Clague MJ, Whitworth AJ. Basal mitophagy is widespread inbut minimally affected by loss of Pink1 or parkin. The Journal of Cell Biology. PMID 29500189 DOI: 10.1083/jcb.201801044 |
0.339 |
|
| 2017 |
Khalil B, Cabirol-Pol MJ, Miguel L, Whitworth AJ, Lecourtois M, Liévens JC. Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies. Neurobiology of Aging. 54: 71-83. PMID 28324764 DOI: 10.1016/J.Neurobiolaging.2017.02.016 |
0.334 |
|
| 2017 |
Whitworth AJ, Pallanck LJ. PINK1/Parkin mitophagy and neurodegeneration-what do we really know in vivo? Current Opinion in Genetics & Development. 44: 47-53. PMID 28213158 DOI: 10.1016/j.gde.2017.01.016 |
0.676 |
|
| 2017 |
Hewitt VL, Whitworth AJ. Mechanisms of Parkinson's Disease: Lessons from Drosophila. Current Topics in Developmental Biology. 121: 173-200. PMID 28057299 DOI: 10.1016/bs.ctdb.2016.07.005 |
0.45 |
|
| 2016 |
Sanchez-Martinez A, Beavan M, Gegg ME, Chau KY, Whitworth AJ, Schapira AH. Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models. Scientific Reports. 6: 31380. PMID 27539639 DOI: 10.1038/srep31380 |
0.334 |
|
| 2015 |
Malik BR, Godena VK, Whitworth AJ. VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin. Human Molecular Genetics. 24: 6106-17. PMID 26251041 DOI: 10.1093/hmg/ddv322 |
0.449 |
|
| 2015 |
López Del Amo V, Seco-Cervera M, García-Giménez JL, Whitworth AJ, Pallardó FV, Galindo MI. Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy. Human Molecular Genetics. 24: 21-36. PMID 25122658 DOI: 10.1093/hmg/ddu416 |
0.413 |
|
| 2014 |
Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H, Whitworth AJ. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Plos Genetics. 10: e1004815. PMID 25412178 DOI: 10.1371/journal.pgen.1004815 |
0.421 |
|
| 2014 |
Ivatt RM, Whitworth AJ. SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease. Autophagy. 10: 1476-7. PMID 24991824 DOI: 10.4161/auto.29642 |
0.361 |
|
| 2014 |
Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E, Whitworth AJ. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 8494-9. PMID 24912190 DOI: 10.1073/Pnas.1321207111 |
0.4 |
|
| 2014 |
Ivatt RM, Whitworth AJ. The many faces of mitophagy. Embo Reports. 15: 5-6. PMID 24398127 DOI: 10.1002/embr.201338224 |
0.363 |
|
| 2013 |
Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nature Neuroscience. 16: 1257-65. PMID 23933751 DOI: 10.1038/Nn.3489 |
0.441 |
|
| 2013 |
Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A. TRAP1 rescues PINK1 loss-of-function phenotypes. Human Molecular Genetics. 22: 2829-41. PMID 23525905 DOI: 10.1093/Hmg/Ddt132 |
0.432 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Whitworth AJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.494 |
|
| 2012 |
Sanchez-Martinez A, Calleja M, Peralta S, Matsushima Y, Hernandez-Sierra R, Whitworth AJ, Kaguni LS, Garesse R. Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. Plos One. 7: e43954. PMID 22952820 DOI: 10.1371/Journal.Pone.0043954 |
0.378 |
|
| 2011 |
Pogson JH, Ivatt RM, Whitworth AJ. Molecular mechanisms of PINK1-related neurodegeneration. Current Neurology and Neuroscience Reports. 11: 283-90. PMID 21331528 DOI: 10.1007/s11910-011-0187-x |
0.436 |
|
| 2011 |
Whitworth AJ. Drosophila models of Parkinson's disease. Advances in Genetics. 73: 1-50. PMID 21310293 DOI: 10.1016/B978-0-12-380860-8.00001-X |
0.364 |
|
| 2011 |
Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Human Molecular Genetics. 20: 867-79. PMID 21138942 DOI: 10.1093/hmg/ddq526 |
0.406 |
|
| 2010 |
Ziviani E, Whitworth AJ. How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy. 6: 660-2. PMID 20484985 DOI: 10.4161/auto.6.5.12242 |
0.433 |
|
| 2010 |
Ziviani E, Tao RN, Whitworth AJ. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proceedings of the National Academy of Sciences of the United States of America. 107: 5018-23. PMID 20194754 DOI: 10.1073/pnas.0913485107 |
0.422 |
|
| 2010 |
Kieper N, Holmström KM, Ciceri D, Fiesel FC, Wolburg H, Ziviani E, Whitworth AJ, Martins LM, Kahle PJ, Krüger R. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Experimental Cell Research. 316: 1213-24. PMID 20064504 DOI: 10.1016/j.yexcr.2010.01.005 |
0.405 |
|
| 2009 |
Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway: a mitochondrial quality control system? Journal of Bioenergetics and Biomembranes. 41: 499-503. PMID 19967438 DOI: 10.1007/s10863-009-9253-3 |
0.693 |
|
| 2009 |
Tain LS, Whitworth AJ. Translating translation: regulated protein translation as a biomedical intervention. Fly. 3: 278-80. PMID 19875944 DOI: 10.4161/fly.10309 |
0.347 |
|
| 2009 |
Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, Whitworth AJ. Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nature Neuroscience. 12: 1129-35. PMID 19684592 DOI: 10.1038/nn.2372 |
0.331 |
|
| 2009 |
Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death and Differentiation. 16: 1118-25. PMID 19282869 DOI: 10.1038/Cdd.2009.23 |
0.479 |
|
| 2008 |
Whitworth AJ, Lee JR, Ho VM, Flick R, Chowdhury R, McQuibban GA. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Disease Models & Mechanisms. 1: 168-74; discussion 1. PMID 19048081 DOI: 10.1242/Dmm.000109 |
0.464 |
|
| 2008 |
Whitworth AJ, Pallanck LJ. Genetic models of Parkinson's disease: mechanisms and therapies. Seb Experimental Biology Series. 60: 93-113. PMID 18309789 |
0.615 |
|
| 2008 |
Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway regulates mitochondrial morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 1638-43. PMID 18230723 DOI: 10.1073/Pnas.0709336105 |
0.721 |
|
| 2006 |
Whitworth AJ, Wes PD, Pallanck LJ. Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug Discovery Today. 11: 119-26. PMID 16533709 DOI: 10.1016/S1359-6446(05)03693-7 |
0.652 |
|
| 2005 |
Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Current Biology : Cb. 15: 1572-7. PMID 16139213 DOI: 10.1016/J.Cub.2005.07.064 |
0.637 |
|
| 2005 |
Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 8024-9. PMID 15911761 DOI: 10.1073/Pnas.0501078102 |
0.676 |
|
| 2005 |
Jackson SM, Whitworth AJ, Greene JC, Libby RT, Baccam SL, Pallanck LJ, La Spada AR. A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage. Gene. 347: 35-41. PMID 15715978 DOI: 10.1016/j.gene.2004.12.008 |
0.619 |
|
| 2005 |
Greene JC, Whitworth AJ, Andrews LA, Parker TJ, Pallanck LJ. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Human Molecular Genetics. 14: 799-811. PMID 15689351 DOI: 10.1093/hmg/ddi074 |
0.658 |
|
| 2005 |
Pallanck LJ, Whitworth AJ. Drosophila models of parkinson disease Movement Disorders. 173-182. DOI: 10.1016/B978-012088382-0/50014-1 |
0.623 |
|
| 2003 |
Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proceedings of the National Academy of Sciences of the United States of America. 100: 4078-83. PMID 12642658 DOI: 10.1073/Pnas.0737556100 |
0.709 |
|
| 2003 |
Whitworth AJ, Russell S. Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing. Developmental Biology. 254: 277-88. PMID 12591247 DOI: 10.1016/S0012-1606(02)00036-2 |
0.429 |
|
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