Ashley E. Brady, Ph.D. - Publications

Affiliations: 
2003 Vanderbilt University, Nashville, TN 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2011 Brady AE, Chen Y, Limbird LE, Wang Q. Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 746: 347-55. PMID 21607867 DOI: 10.1007/978-1-61779-126-0_19  0.96
2010 Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI. Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. Acs Chemical Neuroscience. 1: 542-551. PMID 20835371 DOI: 10.1021/cn100011e  0.96
2009 Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14271-86. PMID 19906975 DOI: 10.1523/JNEUROSCI.3930-09.2009  0.96
2009 Kennedy JP, Bridges TM, Gentry PR, Brogan JT, Kane AS, Jones CK, Brady AE, Shirey JK, Conn PJ, Lindsley CW. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor. Chemmedchem. 4: 1600-7. PMID 19705385 DOI: 10.1002/cmdc.200900231  0.96
2009 Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular Pharmacology. 75: 577-88. PMID 19047481 DOI: 10.1124/mol.108.052886  0.96
2008 Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10422-33. PMID 18842902 DOI: 10.1523/JNEUROSCI.1850-08.2008  0.96
2008 Miller NR, Daniels RN, Bridges TM, Brady AE, Conn PJ, Lindsley CW. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorganic & Medicinal Chemistry Letters. 18: 5443-7. PMID 18829311 DOI: 10.1016/j.bmcl.2008.09.032  0.96
2008 Bridges TM, Brady AE, Kennedy JP, Daniels RN, Miller NR, Kim K, Breininger ML, Gentry PR, Brogan JT, Jones CK, Conn PJ, Lindsley CW. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorganic & Medicinal Chemistry Letters. 18: 5439-42. PMID 18805692 DOI: 10.1016/j.bmcl.2008.09.023  0.96
2008 Brady AE, Jones CK, Bridges TM, Kennedy JP, Thompson AD, Heiman JU, Breininger ML, Gentry PR, Yin H, Jadhav SB, Shirey JK, Conn PJ, Lindsley CW. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. The Journal of Pharmacology and Experimental Therapeutics. 327: 941-53. PMID 18772318 DOI: 10.1124/jpet.108.140350  0.96
2008 Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology. 4: 42-50. PMID 18059262 DOI: 10.1038/nchembio.2007.55  0.96
2007 Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. The Journal of Pharmacology and Experimental Therapeutics. 322: 254-64. PMID 17416742 DOI: 10.1124/jpet.106.117093  0.96
2006 Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Molecular Pharmacology. 70: 616-26. PMID 16645124 DOI: 10.1124/mol.105.021857  0.96
2005 Brady AE, Wang Q, Allen PB, Rizzo M, Greengard P, Limbird LE. Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype. Molecular Pharmacology. 67: 1690-6. PMID 15705742 DOI: 10.1124/mol.104.005215  0.96
2004 Brady AE, Wang Q, Limbird LE. Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 259: 371-8. PMID 15250505 DOI: 10.1385/1-59259-754-8:371  0.96
2004 Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/science.1098274  0.96
2004 Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE. Membrane trafficking of G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 44: 559-609. PMID 14744258 DOI: 10.1146/annurev.pharmtox.44.101802.121558  0.96
2003 Patterson D, Webster J, McInnes G, Brady A, MacDonald T. The effects of KT3-671, a new angiotensin II (AT 1) receptor blocker in mild to moderate hypertension British Journal of Clinical Pharmacology. 56: 513-519. PMID 14651725 DOI: 10.1046/j.1365-2125.2003.01932.x  0.96
2003 Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. The Journal of Biological Chemistry. 278: 32405-12. PMID 12738775 DOI: 10.1074/jbc.M304195200  0.96
2002 Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cellular Signalling. 14: 297-309. PMID 11858937 DOI: 10.1016/S0898-6568(01)00239-X  0.96
2001 Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. The Journal of Biological Chemistry. 276: 15003-8. PMID 11154706 DOI: 10.1074/jbc.M011679200  0.96
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