Norman Haughey - Publications

Johns Hopkins University, Baltimore, MD 
Sphingolipids and Neurodegeneration

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yoo SW, Waheed AA, Deme P, Tohumeken S, Rais R, Smith MD, DeMarino C, Calabresi PA, Kashanchi F, Freed EO, Slusher BS, Haughey NJ. Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219543120. PMID 37406092 DOI: 10.1073/pnas.2219543120  0.301
2019 Taïb B, Aboussalah AM, Moniruzzaman M, Chen S, Haughey NJ, Kim SF, Ahima RS. Lipid accumulation and oxidation in glioblastoma multiforme. Scientific Reports. 9: 19593. PMID 31863022 DOI: 10.1038/s41598-019-55985-z  0.503
2019 Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. Aids (London, England). 33: 973-984. PMID 30946151 DOI: 10.1097/Qad.0000000000002150  0.354
2019 Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, ... ... Haughey N, et al. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nature Neuroscience. PMID 30936556 DOI: 10.1038/S41593-019-0366-7  0.344
2019 Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, ... ... Haughey NJ, et al. Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology. PMID 30787163 DOI: 10.1212/Wnl.0000000000007125  0.334
2018 Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, ... Haughey N, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Scientific Reports. 8: 17715. PMID 30531925 DOI: 10.1038/S41598-018-36144-2  0.327
2017 Hu G, Yelamanchili S, Kashanchi F, Haughey N, Bond VC, Witwer KW, Pulliam L, Buch S. Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs". Journal of Neurovirology. PMID 29147885 DOI: 10.1007/S13365-017-0599-8  0.368
2017 Sacktor N, Skolasky RL, Moxley R, Wang S, Mielke MM, Munro C, Steiner J, Nath A, Haughey N, McArthur J. Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. Journal of Neurovirology. PMID 29063516 DOI: 10.1007/S13365-017-0587-Z  0.366
2017 Couch Y, Akbar N, Roodselaar J, Evans MC, Gardiner C, Sargent I, Romero IA, Bristow A, Buchan AM, Haughey N, Anthony DC. Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation. Scientific Reports. 7: 9574. PMID 28851955 DOI: 10.1038/S41598-017-09710-3  0.305
2017 Hu G, Witwer KW, Bond VC, Haughey N, Kashanchi F, Pulliam L, Buch S. Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs". Journal of Extracellular Vesicles. 6: 1294360. PMID 28800366 DOI: 10.1080/20013078.2017.1294360  0.38
2017 Dickens AM, Yoo SW, Chin AC, Xu J, Johnson TP, Trout AL, Hauser KF, Haughey NJ. Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging. Scientific Reports. 7: 7748. PMID 28798382 DOI: 10.1038/S41598-017-07570-5  0.31
2017 Dickens AM, Tovar-Y-Romo LB, Yoo SW, Trout AL, Bae M, Kanmogne M, Megra B, Williams DW, Witwer KW, Gacias M, Tabatadze N, Cole RN, Casaccia P, Berman JW, Anthony DC, ... Haughey NJ, et al. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Science Signaling. 10. PMID 28377412 DOI: 10.1126/Scisignal.Aai7696  0.662
2017 Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity. Nature Structural & Molecular Biology. PMID 28218748 DOI: 10.1038/Nsmb.3379  0.323
2017 Yoo SW, Bae M, Tovar-Y-Romo LB, Haughey NJ. Hippocampal encoding of interoceptive context during fear conditioning. Translational Psychiatry. 7: e991. PMID 28045462 DOI: 10.1038/Tp.2016.254  0.653
2017 Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, et al. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. The American Journal of Pathology. 187: 91-109. PMID 27993242 DOI: 10.1016/J.Ajpath.2016.09.006  0.303
2016 Almad AA, Doreswamy A, Gross SK, Richard JP, Huo Y, Haughey N, Maragakis NJ. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. PMID 27083773 DOI: 10.1002/glia.22989  0.319
2016 Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nature Reviews. Neurology. PMID 26965674 DOI: 10.1038/Nrneurol.2016.27  0.412
2015 Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 200-16. PMID 25404050 DOI: 10.1007/S13311-014-0315-9  0.309
2014 Merali S, Barrero CA, Sacktor NC, Haughey NJ, Datta PK, Langford D, Khalili K. Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders. Journal of Aids & Clinical Research. 5: 1000312. PMID 25893137 DOI: 10.4172/2155-6113.1000312  0.313
2014 Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D, et al. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. Journal of Neurovirology. 20: 620-6. PMID 25377444 DOI: 10.1007/S13365-014-0292-0  0.37
2014 Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson MP, Haughey NJ. Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11485-503. PMID 25143627 DOI: 10.1523/Jneurosci.0210-14.2014  0.328
2013 Tovar-Y-Romo LB, Kolson DL, Bandaru VV, Drewes JL, Graham DR, Haughey NJ. Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 998-1009. PMID 23686368 DOI: 10.1007/S11481-013-9471-7  0.701
2013 Chen X, Hui L, Geiger NH, Haughey NJ, Geiger JD. Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production. Neurobiology of Aging. 34: 2370-8. PMID 23673310 DOI: 10.1016/J.Neurobiolaging.2013.04.015  0.31
2012 Tovar-y-Romo LB, Bumpus NN, Pomerantz D, Avery LB, Sacktor N, McArthur JC, Haughey NJ. Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz. The Journal of Pharmacology and Experimental Therapeutics. 343: 696-703. PMID 22984227 DOI: 10.1124/Jpet.112.195701  0.693
2012 Hui L, Chen X, Haughey NJ, Geiger JD. Role of endolysosomes in HIV-1 Tat-induced neurotoxicity. Asn Neuro. 4: 243-52. PMID 22591512 DOI: 10.1042/An20120017  0.341
2012 Hui L, Chen X, Bhatt D, Geiger NH, Rosenberger TA, Haughey NJ, Masino SA, Geiger JD. Ketone bodies protection against HIV-1 Tat-induced neurotoxicity. Journal of Neurochemistry. 122: 382-91. PMID 22524563 DOI: 10.1111/J.1471-4159.2012.07764.X  0.338
2012 Wojna V, Curry T, Haughey N, Bandaru V, Skolasky R, Hachavarria R, Mayo R, Bryant C, Anderson C, Fernandez M, Velez J, Nath A. Gonadal Hormone Dysfunction Modulates CSF Oxidative Stress Markers in HIV-Seropositive Women with Cognitive Impairment (S37.002) Neurology. 78. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S37.002  0.31
2011 Xu H, Bae M, Tovar-y-Romo LB, Patel N, Bandaru VV, Pomerantz D, Steiner JP, Haughey NJ. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17074-90. PMID 22114277 DOI: 10.1523/Jneurosci.4072-11.2011  0.678
2011 Haughey NJ, Tovar-y-Romo LB, Bandaru VV. Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 284-95. PMID 21445582 DOI: 10.1007/S11481-011-9274-7  0.683
2011 Lee MH, Wang T, Jang MH, Steiner J, Haughey N, Ming GL, Song H, Nath A, Venkatesan A. Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease. Neurobiology of Disease. 41: 678-87. PMID 21146610 DOI: 10.1016/J.Nbd.2010.12.002  0.445
2009 Varma R, Chai Y, Troncoso J, Gu J, Xing H, Stojilkovic SS, Mattson MP, Haughey NJ. Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity. Neuromolecular Medicine. 11: 63-75. PMID 19562525 DOI: 10.1007/S12017-009-8073-2  0.322
2007 Steiner JP, Galey D, Haughey NJ, Asch D, Nath A. Neuroprotective and antiretroviral effects of the immunophilin ligand GPI 1046. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 49-57. PMID 18040826 DOI: 10.1007/S11481-006-9060-0  0.333
2007 Chen W, Mi R, Haughey N, Oz M, Höke A. Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line. Journal of the Peripheral Nervous System : Jpns. 12: 121-30. PMID 17565537 DOI: 10.1111/j.1529-8027.2007.00131.x  0.321
2006 Steiner J, Haughey N, Li W, Venkatesan A, Anderson C, Reid R, Malpica T, Pocernich C, Butterfield DA, Nath A. Oxidative stress and therapeutic approaches in HIV dementia. Antioxidants & Redox Signaling. 8: 2089-100. PMID 17034352 DOI: 10.1089/Ars.2006.8.2089  0.409
2006 Caporello E, Nath A, Slevin J, Galey D, Hamilton G, Williams L, Steiner JP, Haughey NJ. The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load. Journal of Neurochemistry. 98: 146-55. PMID 16805804 DOI: 10.1111/J.1471-4159.2006.03863.X  0.316
2006 Turchan-Cholewo J, Liu Y, Gartner S, Reid R, Jie C, Peng X, Chen KC, Chauhan A, Haughey N, Cutler R, Mattson MP, Pardo C, Conant K, Sacktor N, McArthur JC, et al. Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl. Neurobiology of Disease. 23: 109-19. PMID 16697650 DOI: 10.1016/J.Nbd.2006.02.005  0.408
2006 Wang T, Allie R, Conant K, Haughey N, Turchan-Chelowo J, Hahn K, Rosen A, Steiner J, Keswani S, Jones M, Calabresi PA, Nath A. Granzyme B mediates neurotoxicity through a G-protein-coupled receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1209-11. PMID 16636104 DOI: 10.1096/Fj.05-5022Fje  0.329
2005 Mattson MP, Haughey NJ, Nath A. Cell death in HIV dementia. Cell Death and Differentiation. 12: 893-904. PMID 15761472 DOI: 10.1038/Sj.Cdd.4401577  0.368
2004 Sacktor N, Haughey N, Cutler R, Tamara A, Turchan J, Pardo C, Vargas D, Nath A. Novel markers of oxidative stress in actively progressive HIV dementia. Journal of Neuroimmunology. 157: 176-84. PMID 15579295 DOI: 10.1016/J.Jneuroim.2004.08.037  0.376
2004 Bilak M, Wu L, Wang Q, Haughey N, Conant K, St Hillaire C, Andreasson K. PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Annals of Neurology. 56: 240-8. PMID 15293276 DOI: 10.1002/Ana.20179  0.331
2004 Haughey NJ, Cutler RG, Tamara A, McArthur JC, Vargas DL, Pardo CA, Turchan J, Nath A, Mattson MP. Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Annals of Neurology. 55: 257-67. PMID 14755730 DOI: 10.1002/Ana.10828  0.368
2004 McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 257-68. PMID 14715958 DOI: 10.1523/Jneurosci.4485-03.2004  0.347
2003 Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A. Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. Journal of Neurovirology. 9: 358-71. PMID 12775419 DOI: 10.1080/13550280390201119  0.404
2003 McArthur JC, Haughey N, Gartner S, Conant K, Pardo C, Nath A, Sacktor N. Human immunodeficiency virus-associated dementia: an evolving disease. Journal of Neurovirology. 9: 205-21. PMID 12707851 DOI: 10.1080/13550280390194109  0.323
2002 Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiology of Disease. 11: 2-19. PMID 12460542 DOI: 10.1006/Nbdi.2002.0542  0.301
2002 Haughey NJ, Mattson MP. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. Journal of Acquired Immune Deficiency Syndromes (1999). 31: S55-61. PMID 12394783 DOI: 10.1097/00126334-200210012-00005  0.343
2002 Mattson MP, Duan W, Chan SL, Cheng A, Haughey N, Gary DS, Guo Z, Lee J, Furukawa K. Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior. Neurobiology of Aging. 23: 695-705. PMID 12392775 DOI: 10.1016/S0197-4580(02)00025-8  0.332
2002 Tomac AC, Agulnick AD, Haughey N, Chang CF, Zhang Y, Bäckman C, Morales M, Mattson MP, Wang Y, Westphal H, Hoffer BJ. Effects of cerebral ischemia in mice deficient in Persephin. Proceedings of the National Academy of Sciences of the United States of America. 99: 9521-6. PMID 12093930 DOI: 10.1073/Pnas.152535899  0.326
2002 Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1752-62. PMID 11880504 DOI: 10.1523/Jneurosci.22-05-01752.2002  0.301
2001 Lu C, Chan SL, Haughey N, Lee WT, Mattson MP. Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-D-aspartate channels. Journal of Neurochemistry. 78: 577-89. PMID 11483661 DOI: 10.1046/J.1471-4159.2001.00431.X  0.377
2001 Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. Journal of Neurochemistry. 78: 457-67. PMID 11483648 DOI: 10.1046/J.1471-4159.2001.00396.X  0.421
2000 Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Annals of Neurology. 47: 186-94. PMID 10665489 DOI: 10.1002/1531-8249(200002)47:2<186::Aid-Ana8>3.0.Co;2-3  0.333
1999 Holden CP, Haughey NJ, Nath A, Geiger JD. Role of Na+/H+ exchangers, excitatory amino acid receptors and voltage-operated Ca2+ channels in human immunodeficiency virus type 1 gp120-mediated increases in intracellular Ca2+ in human neurons and astrocytes. Neuroscience. 91: 1369-78. PMID 10391443 DOI: 10.1016/S0306-4522(98)00714-3  0.36
1996 Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. Journal of Virology. 70: 1475-80. PMID 8627665 DOI: 10.1128/Jvi.70.3.1475-1480.1996  0.36
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