Kangning Liu, Ph.D. - Related publications

Affiliations: 
2005 University of Pennsylvania, Philadelphia, PA, United States 
Area:
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Zimmer JA, Shcherbinin S, Devous MD, Bragg SM, Selzler KJ, Wessels AM, Shering C, Mullen J, Landry J, Andersen SW, Downing AM, Fleisher AS, Svaldi DO, Sims JR. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12123. PMID 33614894 DOI: 10.1002/trc2.12123   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Lee SB, Park A, Ma CT, Kim YH, Yang HO. 3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells. Biomolecules & Therapeutics. PMID 33619237 DOI: 10.4062/biomolther.2020.195   
2021 Zheng X, Lin W, Jiang Y, Lu K, Wei W, Huo Q, Cui S, Yang X, Li M, Xu N, Tang C, Song JX. Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 1-15. PMID 33622188 DOI: 10.1080/15548627.2021.1886720   
2021 Brown A, Török M. Functional amyloids in the human body. Bioorganic & Medicinal Chemistry Letters. 127914. PMID 33691165 DOI: 10.1016/j.bmcl.2021.127914   
2021 Keshavan A, Wellington H, Chen Z, Khatun A, Chapman M, Hart M, Cash DM, Coath W, Parker TD, Buchanan SM, Keuss SE, Harris MJ, Murray-Smith H, Heslegrave A, Fox NC, et al. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12131. PMID 33598527 DOI: 10.1002/dad2.12131   
2021 Alakbarzade V, French JM, Howlett DR, Attems J, Francis PT, Stratton S, Clark CN, Pereira AC, Hainsworth AH. Cerebral amyloid angiopathy distribution in older people: A cautionary note. Alzheimer's & Dementia (New York, N. Y.). 7: e12145. PMID 33644295 DOI: 10.1002/trc2.12145   
2021 Tosh JL, Rhymes ER, Mumford P, Whittaker HT, Pulford LJ, Noy SJ, Cleverley K, , Walker MC, Tybulewicz VLJ, Wykes RC, Fisher EMC, Wiseman FK. Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. Scientific Reports. 11: 5736. PMID 33707583 DOI: 10.1038/s41598-021-85062-3   
2021 Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033   
2021 Abbaszadeh M, Sahin M, Ozgun A, Oncu G, Garipcan B, Saybasili H. A Transient Survival Model of Alteration of Electrophysiological Properties Due to Amyloid-Beta Toxicity Based on SH-SY5Y Cell Line. Current Alzheimer Research. PMID 33583383 DOI: 10.2174/1567205018666210212155750   
2021 Ashford MT, Veitch DP, Neuhaus J, Nosheny RL, Tosun D, Weiner MW. The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33583100 DOI: 10.1002/alz.12253   
2021 Möllers T, Stocker H, Perna L, Nabers A, Rujescu D, Hartmann AM, Holleczek B, Schöttker B, Gerwert K, Brenner H. Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12151. PMID 33614887 DOI: 10.1002/dad2.12151   
2021 Lee JH, Ahn NH, Choi SB, Kwon Y, Yang SH. Natural Products Targeting Amyloid Beta in Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33652858 DOI: 10.3390/ijms22052341   
2021 Khan A, Das S, Sergi C. Therapeutic Potential of Neu1 in Alzheimer's Disease Via the Immune System. American Journal of Alzheimer's Disease and Other Dementias. 36: 1533317521996147. PMID 33719595 DOI: 10.1177/1533317521996147   
2021 Paulus A, Engdahl A, Yang Y, Boza-Serrano A, Bachiller S, Torres-Garcia L, Svanbergsson A, Garcia MG, Gouras GK, Li JY, Deierborg T, Klementieva O. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33810433 DOI: 10.3390/ijms22073430   
2021 Yang J, Perrett S, Wu S. Single Molecule Characterization of Amyloid Oligomers. Molecules (Basel, Switzerland). 26. PMID 33670093 DOI: 10.3390/molecules26040948   
2021 Miranda A, Montiel E, Ulrich H, Paz C. Selective Secretase Targeting for Alzheimer's Disease Therapy. Journal of Alzheimer's Disease : Jad. PMID 33749645 DOI: 10.3233/JAD-201027   
2021 Foley AR, Raskatov JA. Understanding and controlling amyloid aggregation with chirality. Current Opinion in Chemical Biology. 64: 1-9. PMID 33610939 DOI: 10.1016/j.cbpa.2021.01.003   
2021 Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER, Filshtein TJ, Power MC, Elahi FM, Brickman AM, Glymour MM. Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis. Bmj (Clinical Research Ed.). 372: n156. PMID 33632704 DOI: 10.1136/bmj.n156   
2021 Qiu Z, Shen Q, Jiang C, Yao L, Sun X, Li J, Duan C, Li R, Li X, Gopinath SCB, Anbu P, Lakshmipriya T, Li X. Alzheimer's Disease Determination by a Dual Probe on Gold Nanourchins and Nanohorn Hybrids. International Journal of Nanomedicine. 16: 2311-2322. PMID 33776435 DOI: 10.2147/IJN.S302396   
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313   
2021 Bansal A, Schmidt M, Rennegarbe M, Haupt C, Liberta F, Stecher S, Puscalau-Girtu I, Biedermann A, Fändrich M. AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils. Nature Communications. 12: 1013. PMID 33579941 DOI: 10.1038/s41467-021-21129-z   
2021 Koh SH, Kwon HS, Choi SH, Jeong JH, Na HR, Lee CN, Yang Y, Lee AY, Lee JH, Park KW, Han HJ, Kim BC, Park JS, Lee JY, Kim S, et al. Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer's disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial. Alzheimer's Research & Therapy. 13: 66. PMID 33771205 DOI: 10.1186/s13195-021-00803-w   
2021 Choi J, Chung C, Woo H. Diet-Related Mobile Apps to Promote Healthy Eating and Proper Nutrition: A Content Analysis and Quality Assessment. International Journal of Environmental Research and Public Health. 18. PMID 33800531 DOI: 10.3390/ijerph18073496   
2021 Mintun MA, Lo AC, Duggan Evans C, Wessels AM, Ardayfio PA, Andersen SW, Shcherbinin S, Sparks J, Sims JR, Brys M, Apostolova LG, Salloway SP, Skovronsky DM. Donanemab in Early Alzheimer's Disease. The New England Journal of Medicine. PMID 33720637 DOI: 10.1056/NEJMoa2100708   
2021 Zhang Y, Zhang M, Liu Y, Zhang D, Tang Y, Ren B, Zheng J. Dual amyloid cross-seeding reveals steric zipper-facilitated fibrillization and pathological links between protein misfolding diseases. Journal of Materials Chemistry. B. PMID 33651875 DOI: 10.1039/d0tb02958k   
2021 Morgello S, Cortes EP, Gensler G, Meloni G, Jacobs MM, Murray J, Borukov V, Crary JF. HIV disease duration, but not active brain infection, predicts cortical amyloid beta deposition. Aids (London, England). PMID 33813555 DOI: 10.1097/QAD.0000000000002893   
2021 Takahashi RH, Yokotsuka M, Tobiume M, Sato Y, Hasegawa H, Nagao T, Gouras GK. Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains. Brain Pathology (Zurich, Switzerland). e12941. PMID 33624334 DOI: 10.1111/bpa.12941   
2021 Michiels L, Van Weehaeghe D, Vandenberghe R, Demeestere J, Van Laere K, Lemmens R. The Role of Amyloid PET in Diagnosing Possible Transmissible Cerebral Amyloid Angiopathy in Young Adults with a History of Neurosurgery: A Case Series. Cerebrovascular Diseases (Basel, Switzerland). 1-5. PMID 33744891 DOI: 10.1159/000514139   
2021 Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model. Scientific Reports. 11: 4359. PMID 33623128 DOI: 10.1038/s41598-021-83932-4   
2021 He B, Wang L, Xu B, Zhang Y, . Association between CSF Aβ42 and amyloid negativity in patients with different stage mild cognitive impairment. Neuroscience Letters. 135765. PMID 33667602 DOI: 10.1016/j.neulet.2021.135765   
2021 Jin L, Liu C, Zhang N, Zhang R, Yan M, Bhunia A, Zhang Q, Liu M, Han J, Siebert HC. Attenuation of Human Lysozyme Amyloid Fibrillation by ACE Inhibitor Captopril: A Combined Spectroscopy, Microscopy, Cytotoxicity, and Docking Study. Biomacromolecules. PMID 33844512 DOI: 10.1021/acs.biomac.0c01802   
2021 Yoon JH, Lee N, Youn K, Jo MR, Kim HR, Lee DS, Ho CT, Jun M. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell. Marine Drugs. 19. PMID 33804171 DOI: 10.3390/md19030152   
2021 Locci A, Orellana H, Rodriguez G, Gottliebson M, McClarty B, Dominguez S, Keszycki R, Dong H. Comparison of memory, affective behavior, and neuropathology in APP knock-in mice to 5xFAD and APP/PS1 mice. Behavioural Brain Research. 113192. PMID 33607163 DOI: 10.1016/j.bbr.2021.113192   
2021 Al-Thani HF, Ahmad MN, Younes S, Zayed H. Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review. Alzheimer Disease and Associated Disorders. PMID 33769987 DOI: 10.1097/WAD.0000000000000447   
2021 Bretland KA, Lin L, Bretland KM, Smith MA, Fleming SM, Dengler-Crish CM. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathology and Applied Neurobiology. PMID 33768561 DOI: 10.1111/nan.12711   
2021 Jang M, Choi SH, Choi JH, Oh J, Lee RM, Lee NE, Cho YJ, Rhim H, Kim HC, Cho IH, Nah SY. Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease. Experimental and Therapeutic Medicine. 21: 310. PMID 33717253 DOI: 10.3892/etm.2021.9741   
2021 Davis N, Mota BC, Stead L, Palmer EOC, Lombardero L, Rodríguez-Puertas R, de Paola V, Barnes SJ, Sastre M. Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer's disease. Journal of Neuroinflammation. 18: 73. PMID 33731156 DOI: 10.1186/s12974-021-02117-y   
2021 Delgado A, Cholevas C, Theoharides TC. Neuroinflammation in Alzheimer's disease and beneficial action of luteolin. Biofactors (Oxford, England). PMID 33615581 DOI: 10.1002/biof.1714   
2021 Park KW, Wood CA, Li J, Taylor BC, Oh S, Young NL, Jankowsky JL. Gene therapy using Aβ variants for amyloid reduction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33647457 DOI: 10.1016/j.ymthe.2021.02.026   
2021 Koriyama Y, Hori A, Ito H, Yonezawa S, Baba Y, Tanimoto N, Ueno T, Yamamoto S, Yamamoto T, Asada N, Morimoto K, Einaru S, Sakai K, Kanazu T, Matsuda A, et al. Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of Medicinal Chemistry. 64: 1873-1888. PMID 33588527 DOI: 10.1021/acs.jmedchem.0c01917   
2021 Sharma S. Role of Extracellular vesicles in Alzheimer's disease: Current Advances. Current Molecular Medicine. PMID 33823777 DOI: 10.2174/1566524021666210406121807   
2021 Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of Aging. 103: 31-41. PMID 33789210 DOI: 10.1016/j.neurobiolaging.2021.02.025   
2021 Leinenga G, Koh WK, Götz J. A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research & Therapy. 13: 76. PMID 33836798 DOI: 10.1186/s13195-021-00809-4   
2021 Gao J, Suo C, Tseng JH, Moss MA, Terry AV, Chapman J. Design and Synthesis of Ranitidine Analogs as Multi-Target Directed Ligands for the Treatment of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33803769 DOI: 10.3390/ijms22063120   
2021 Schrott L, Yi P, Jackson K, Jackson GS, Webb C, Minagar A, Yun WJ, Purdum G, Rios DJ, Tyler TA, Vizcanio MI, Castor JL, Castor T, Alexander JS. Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model. Current Alzheimer Research. PMID 33602091 DOI: 10.2174/1567205018666210218155835   
2021 Csincsik L, Nelson R, Walpert MJ, Peto T, Holland A, Lengyel I. Increased choroidal thickness in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12170. PMID 33748396 DOI: 10.1002/dad2.12170   
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w   
2021 Belloy ME, Eger SJ, Le Guen Y, Napolioni V, Deters KD, Yang HS, Scelsi MA, Porter T, James SN, Wong A, Schott JM, Sperling RA, Laws SM, Mormino EC, He Z, ... , ... , ... , ... , et al. KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers. Neurobiology of Aging. 101: 123-129. PMID 33610961 DOI: 10.1016/j.neurobiolaging.2021.01.008   
2021 Deng Z, Wang J, Xiao Y, Li F, Niu L, Liu X, Meng L, Zheng H. Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 11: 4351-4362. PMID 33754065 DOI: 10.7150/thno.52436