Adam S. Crystal, Ph.D. - Related publications

2005 University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Zheng X, Lin W, Jiang Y, Lu K, Wei W, Huo Q, Cui S, Yang X, Li M, Xu N, Tang C, Song JX. Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 1-15. PMID 33622188 DOI: 10.1080/15548627.2021.1886720   
2021 Al-Thani HF, Ahmad MN, Younes S, Zayed H. Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review. Alzheimer Disease and Associated Disorders. PMID 33769987 DOI: 10.1097/WAD.0000000000000447   
2021 Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033   
2021 Chang Z, Deng J, Zhao W, Yang J. Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques. Chemistry and Physics of Lipids. 105062. PMID 33600803 DOI: 10.1016/j.chemphyslip.2021.105062   
2021 Zimmer JA, Shcherbinin S, Devous MD, Bragg SM, Selzler KJ, Wessels AM, Shering C, Mullen J, Landry J, Andersen SW, Downing AM, Fleisher AS, Svaldi DO, Sims JR. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12123. PMID 33614894 DOI: 10.1002/trc2.12123   
2021 Morris DL, Tjandra N. Inducible fold-switching as a mechanism to fibrillate pro-apoptotic BCL-2 proteins. Biopolymers. e23424. PMID 33764501 DOI: 10.1002/bip.23424   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Lee SB, Park A, Ma CT, Kim YH, Yang HO. 3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells. Biomolecules & Therapeutics. PMID 33619237 DOI: 10.4062/biomolther.2020.195   
2021 Brown A, Török M. Functional amyloids in the human body. Bioorganic & Medicinal Chemistry Letters. 127914. PMID 33691165 DOI: 10.1016/j.bmcl.2021.127914   
2021 Tosh JL, Rhymes ER, Mumford P, Whittaker HT, Pulford LJ, Noy SJ, Cleverley K, , Walker MC, Tybulewicz VLJ, Wykes RC, Fisher EMC, Wiseman FK. Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. Scientific Reports. 11: 5736. PMID 33707583 DOI: 10.1038/s41598-021-85062-3   
2021 Mitchell SM, Graham M, Liu X, Leonhardt RM. Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL. Scientific Reports. 11: 7730. PMID 33833328 DOI: 10.1038/s41598-021-87259-y   
2021 Husain MA, Laurent B, Plourde M. APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in Neuroscience. 15: 630502. PMID 33679311 DOI: 10.3389/fnins.2021.630502   
2021 Foley AR, Raskatov JA. Understanding and controlling amyloid aggregation with chirality. Current Opinion in Chemical Biology. 64: 1-9. PMID 33610939 DOI: 10.1016/j.cbpa.2021.01.003   
2021 Paulus A, Engdahl A, Yang Y, Boza-Serrano A, Bachiller S, Torres-Garcia L, Svanbergsson A, Garcia MG, Gouras GK, Li JY, Deierborg T, Klementieva O. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33810433 DOI: 10.3390/ijms22073430   
2021 Miranda A, Montiel E, Ulrich H, Paz C. Selective Secretase Targeting for Alzheimer's Disease Therapy. Journal of Alzheimer's Disease : Jad. PMID 33749645 DOI: 10.3233/JAD-201027   
2021 Wells C, Brennan S, Keon M, Ooi L. The role of amyloid oligomers in neurodegenerative pathologies. International Journal of Biological Macromolecules. PMID 33766600 DOI: 10.1016/j.ijbiomac.2021.03.113   
2021 Belloy ME, Eger SJ, Le Guen Y, Napolioni V, Deters KD, Yang HS, Scelsi MA, Porter T, James SN, Wong A, Schott JM, Sperling RA, Laws SM, Mormino EC, He Z, ... , ... , ... , ... , et al. KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers. Neurobiology of Aging. 101: 123-129. PMID 33610961 DOI: 10.1016/j.neurobiolaging.2021.01.008   
2021 Bansal A, Schmidt M, Rennegarbe M, Haupt C, Liberta F, Stecher S, Puscalau-Girtu I, Biedermann A, Fändrich M. AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils. Nature Communications. 12: 1013. PMID 33579941 DOI: 10.1038/s41467-021-21129-z   
2021 Takahashi RH, Yokotsuka M, Tobiume M, Sato Y, Hasegawa H, Nagao T, Gouras GK. Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains. Brain Pathology (Zurich, Switzerland). e12941. PMID 33624334 DOI: 10.1111/bpa.12941   
2021 Khan A, Das S, Sergi C. Therapeutic Potential of Neu1 in Alzheimer's Disease Via the Immune System. American Journal of Alzheimer's Disease and Other Dementias. 36: 1533317521996147. PMID 33719595 DOI: 10.1177/1533317521996147   
2021 Bretland KA, Lin L, Bretland KM, Smith MA, Fleming SM, Dengler-Crish CM. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathology and Applied Neurobiology. PMID 33768561 DOI: 10.1111/nan.12711   
2021 Csincsik L, Nelson R, Walpert MJ, Peto T, Holland A, Lengyel I. Increased choroidal thickness in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12170. PMID 33748396 DOI: 10.1002/dad2.12170   
2021 Zhang Y, Zhang M, Liu Y, Zhang D, Tang Y, Ren B, Zheng J. Dual amyloid cross-seeding reveals steric zipper-facilitated fibrillization and pathological links between protein misfolding diseases. Journal of Materials Chemistry. B. PMID 33651875 DOI: 10.1039/d0tb02958k   
2021 Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Schöll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K. Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology. Acta Neuropathologica. PMID 33585983 DOI: 10.1007/s00401-021-02275-6   
2021 Delgado A, Cholevas C, Theoharides TC. Neuroinflammation in Alzheimer's disease and beneficial action of luteolin. Biofactors (Oxford, England). PMID 33615581 DOI: 10.1002/biof.1714   
2021 Qu Y, Wang W, Chen T, Yang Y, Zhang Y, Wang D. The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling. Aging. 13. PMID 33819182 DOI: 10.18632/aging.202776   
2021 Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of Aging. 103: 31-41. PMID 33789210 DOI: 10.1016/j.neurobiolaging.2021.02.025   
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313   
2021 Yi S, Chen S, Xiang J, Tan J, Huang K, Zhang H, Wang Y, Wu H. Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in Aβ25-35-induced Alzheimer's disease models in vitro. Folia Histochemica Et Cytobiologica. PMID 33605427 DOI: 10.5603/FHC.a2021.0006   
2021 Ni R, Röjdner J, Voytenko L, Dyrks T, Thiele A, Marutle A, Nordberg A. In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK1195 in Autopsy Alzheimer's Brain Tissue. Journal of Alzheimer's Disease : Jad. PMID 33749648 DOI: 10.3233/JAD-201344   
2021 Thompson TB, Meisl G, Knowles TPJ, Goriely A. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of Chemical Physics. 154: 125101. PMID 33810689 DOI: 10.1063/5.0031650   
2021 Stepanchuk AA, Heyne B, Stys PK. Complex Photophysical Properties of K114 Make for a Versatile Fluorescent Probe for Amyloid Detection. Acs Chemical Neuroscience. PMID 33705095 DOI: 10.1021/acschemneuro.1c00101   
2021 Butt OH, Long JM, Henson RL, Herries E, Sutphen CL, Fagan AM, Cruchaga C, Ladenson JH, Holtzman DM, Morris JC, Ances BM, Schindler SE, . Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25. Neurobiology of Aging. 102: 64-72. PMID 33765432 DOI: 10.1016/j.neurobiolaging.2021.02.008   
2021 Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease. Plos Genetics. 17: e1009406. PMID 33830999 DOI: 10.1371/journal.pgen.1009406   
2021 Roberts C, Kaplow J, Giroux M, Krause S, Kanekiyo M. Amyloid and APOE Status of Screened Subjects in the Elenbecestat MissionAD Phase 3 Program. The Journal of Prevention of Alzheimer's Disease. 8: 218-223. PMID 33569570 DOI: 10.14283/jpad.2021.4   
2021 Nakamura M, Li Y, Choi BR, Matas-Rico E, Troncoso J, Takahashi C, Sockanathan S. GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein. Science Translational Medicine. 13. PMID 33731436 DOI: 10.1126/scitranslmed.abe6178   
2021 He B, Wang L, Xu B, Zhang Y, . Association between CSF Aβ42 and amyloid negativity in patients with different stage mild cognitive impairment. Neuroscience Letters. 135765. PMID 33667602 DOI: 10.1016/j.neulet.2021.135765   
2021 Gaudreault R, Hervé V, van de Ven TGM, Mousseau N, Ramassamy C. Polyphenol-Peptide Interactions in Mitigation of Alzheimer's Disease: Role of Biosurface-Induced Aggregation. Journal of Alzheimer's Disease : Jad. PMID 33749653 DOI: 10.3233/JAD-201549   
2021 Li Y, Tang H, Andrikopoulos N, Javed I, Cecchetto L, Nandakumar A, Kakinen A, Davis TP, Ding F, Ke PC. The membrane axis of Alzheimer's nanomedicine. Advanced Nanobiomed Research. 1. PMID 33748816 DOI: 10.1002/anbr.202000040   
2021 Geisler SM, Benedetti A, Schöpf CL, Schwarzer C, Stefanova N, Schwartz A, Obermair GJ. Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit αδ-2 Mutant (Ducky) and αδ Double Knockout Mice. Frontiers in Synaptic Neuroscience. 13: 634412. PMID 33679366 DOI: 10.3389/fnsyn.2021.634412   
2021 Lee JH, Ahn NH, Choi SB, Kwon Y, Yang SH. Natural Products Targeting Amyloid Beta in Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33652858 DOI: 10.3390/ijms22052341   
2021 Dhakal S, Wyant CE, George HE, Morgan SE, Rangachari V. Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils. Journal of Molecular Biology. 166953. PMID 33771571 DOI: 10.1016/j.jmb.2021.166953   
2021 Sharma S. Role of Extracellular vesicles in Alzheimer's disease: Current Advances. Current Molecular Medicine. PMID 33823777 DOI: 10.2174/1566524021666210406121807   
2021 Balana AT, Levine PM, Craven TW, Mukherjee S, Pedowitz NJ, Moon SP, Takahashi TT, Becker CFW, Baker D, Pratt MR. O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity. Nature Chemistry. PMID 33723378 DOI: 10.1038/s41557-021-00648-8   
2021 Sait A, Angeli C, Doig AJ, Day PJR. Viral Involvement in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33687205 DOI: 10.1021/acschemneuro.0c00719   
2021 Yoon JH, Lee N, Youn K, Jo MR, Kim HR, Lee DS, Ho CT, Jun M. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell. Marine Drugs. 19. PMID 33804171 DOI: 10.3390/md19030152   
2021 Yang J, Perrett S, Wu S. Single Molecule Characterization of Amyloid Oligomers. Molecules (Basel, Switzerland). 26. PMID 33670093 DOI: 10.3390/molecules26040948   
2021 Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J. Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. Neurobiology of Aging. PMID 33789815 DOI: 10.1016/j.neurobiolaging.2021.02.021   
2021 Koriyama Y, Hori A, Ito H, Yonezawa S, Baba Y, Tanimoto N, Ueno T, Yamamoto S, Yamamoto T, Asada N, Morimoto K, Einaru S, Sakai K, Kanazu T, Matsuda A, et al. Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of Medicinal Chemistry. 64: 1873-1888. PMID 33588527 DOI: 10.1021/acs.jmedchem.0c01917   
2021 Al-Shabib NA, Khan JM, Malik A, Rehman MT, Husain FM, AlAjmi MF, Hamdan Ali Alghamdi O, Khan A. Quinoline yellow dye stimulates whey protein fibrillation via electrostatic and hydrophobic interaction: A biophysical study. Journal of Dairy Science. PMID 33685710 DOI: 10.3168/jds.2020-19766