Deepak M. Sampathu, Ph.D. - Related publications

2006 University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Song L, Wells EA, Robinson AS. Critical Molecular and Cellular Contributors to Tau Pathology. Biomedicines. 9. PMID 33672982 DOI: 10.3390/biomedicines9020190   
2021 Ajoolabady A, Aslkhodapasandhokmabad H, Henninger N, Demillard LJ, Nikanfar M, Nourazarian A, Ren J. Targeting Autophagy in Neurodegenerative Diseases: from Molecular Mechanisms to Clinical Therapeutics. Clinical and Experimental Pharmacology & Physiology. PMID 33752254 DOI: 10.1111/1440-1681.13500   
2021 Kwon OC, Song JJ, Yang Y, Kim SH, Kim JY, Seok MJ, Hwang I, Yu JW, Karmacharya J, Maeng HJ, Kim J, Jho EH, Ko SY, Son H, Chang MY, et al. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. Embo Molecular Medicine. e13076. PMID 33646633 DOI: 10.15252/emmm.202013076   
2021 Chang CW, Shao E, Mucke L. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). 371. PMID 33632820 DOI: 10.1126/science.abb8255   
2021 Tavassoly O, Del Cid Pellitero E, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33713002 DOI: 10.1007/s13311-021-01017-6   
2021 Follett J, Farrer MJ. LRRK2; a dynamic regulator of cellular trafficking. Brain Research. 1761: 147394. PMID 33662339 DOI: 10.1016/j.brainres.2021.147394   
2021 Stojkovska I, Mazzulli JR. Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. Star Protocols. 2: 100372. PMID 33733241 DOI: 10.1016/j.xpro.2021.100372   
2021 Mueller RL, Combs B, Alhadidy MM, Brady ST, Morfini GA, Kanaan NM. Tau: A Signaling Hub Protein. Frontiers in Molecular Neuroscience. 14: 647054. PMID 33815057 DOI: 10.3389/fnmol.2021.647054   
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9   
2021 Peyron PA, Hirtz C, Baccino E, Ginestet N, Tiers L, Martinez AY, Lehmann S, Delaby C. Tau protein in cerebrospinal fluid: a novel biomarker of the time of death? International Journal of Legal Medicine. PMID 33740116 DOI: 10.1007/s00414-021-02558-3   
2021 Criado-Marrero M, Gebru NT, Blazier DM, Gould LA, Baker JD, Beaulieu-Abdelahad D, Blair LJ. Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. Acta Neuropathologica Communications. 9: 65. PMID 33832539 DOI: 10.1186/s40478-021-01159-w   
2021 Chen X, Zhang Y, Wang Q, Qin Y, Yang X, Xing Z, Shen Y, Wu H, Qi Y. The function of SUMOylation and its crucial roles in the development of neurological diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21510. PMID 33710677 DOI: 10.1096/fj.202002702R   
2021 Xing J, Xu C. Role of connexins in neurodegenerative diseases (Review). Molecular Medicine Reports. 23. PMID 33760195 DOI: 10.3892/mmr.2021.12034   
2021 Xu MM, Zhou MT, Li SW, Zhen XC, Yang S. Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach. Journal of Neuroscience Research. PMID 33634546 DOI: 10.1002/jnr.24805   
2021 Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY. LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons. Journal of Parkinson's Disease. PMID 33720852 DOI: 10.3233/JPD-212562   
2021 Ravanfar P, Loi SM, Syeda WT, Van Rheenen TE, Bush AI, Desmond P, Cropley VL, Lane DJR, Opazo CM, Moffat BA, Velakoulis D, Pantelis C. Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases. Frontiers in Neuroscience. 15: 618435. PMID 33679303 DOI: 10.3389/fnins.2021.618435   
2021 Nam Y, Moon GJ, Kim SR. Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases. International Journal of Molecular Sciences. 22. PMID 33802760 DOI: 10.3390/ijms22063064   
2021 Root J, Merino P, Nuckols A, Johnson M, Kukar T. Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiology of Disease. 105360. PMID 33812000 DOI: 10.1016/j.nbd.2021.105360   
2021 Holbrook JA, Jarosz-Griffiths HH, Caseley E, Lara-Reyna S, Poulter JA, Williams-Gray CH, Peckham D, McDermott MF. Neurodegenerative Disease and the NLRP3 Inflammasome. Frontiers in Pharmacology. 12: 643254. PMID 33776778 DOI: 10.3389/fphar.2021.643254   
2021 McMurray L, Macdonald JA, Ramakrishnan NK, Zhao Y, Williamson DW, Tietz O, Zhou X, Kealey S, Fagan SG, Smolek T, Cubinkova V, Žilka N, Spillantini MG, Tolkovsky AM, Goedert M, et al. Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models. Acs Chemical Neuroscience. PMID 33689290 DOI: 10.1021/acschemneuro.0c00790   
2021 Vasconcelos IC, Campos RM, Schwaemmle HM, Masson AP, Ferrari GD, Alberici LC, Faça VM, Garcia-Cairasco N, Sebollela A. A freeze-and-thaw induced-fragment of the microtubule-associated protein Tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity. Bioscience Reports. PMID 33629708 DOI: 10.1042/BSR20203980   
2021 Singh A, Agrawal N. Deciphering the key mechanisms leading to alteration of lipid metabolism in Drosophila model of Huntington's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166127. PMID 33722743 DOI: 10.1016/j.bbadis.2021.166127   
2021 He S, Wang F, Yung KKL, Zhang S, Qu S. Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease. Acs Chemical Neuroscience. PMID 33769791 DOI: 10.1021/acschemneuro.1c00028   
2021 Reyes JF, Ekmark-Léwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M. Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease. Acta Neuropathologica Communications. 9: 46. PMID 33743820 DOI: 10.1186/s40478-021-01136-3   
2021 Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F. SGTA associates with intracellular aggregates in neurodegenerative diseases. Molecular Brain. 14: 59. PMID 33757575 DOI: 10.1186/s13041-021-00770-1   
2021 Xiao S, Lu Y, Wu Q, Yang J, Chen J, Zhong S, Eliezer D, Tan Q, Wu C. Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International Journal of Biological Macromolecules. PMID 33662414 DOI: 10.1016/j.ijbiomac.2021.02.210   
2021 Wells C, Brennan S, Keon M, Ooi L. The role of amyloid oligomers in neurodegenerative pathologies. International Journal of Biological Macromolecules. PMID 33766600 DOI: 10.1016/j.ijbiomac.2021.03.113   
2021 Soares AC, Ferreira A, Mariën J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynck L. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. The Journal of Biological Chemistry. 100636. PMID 33831417 DOI: 10.1016/j.jbc.2021.100636   
2021 Kawakami I, Motoda A, Hashimoto M, Shimozawa A, Masuda-Suzukake M, Ohtani R, Takase M, Kumashiro M, Samejima K, Hasegawa M. Progression of phosphorylated α-synuclein in Macaca fuscata. Brain Pathology (Zurich, Switzerland). e12952. PMID 33754430 DOI: 10.1111/bpa.12952   
2021 Darling AL, Dahrendorff J, Creodore SG, Dickey CA, Blair LJ, Uversky VN. Small heat shock protein 22kDa can modulate the aggregation and liquid-liquid phase separation behavior of Tau. Protein Science : a Publication of the Protein Society. PMID 33686711 DOI: 10.1002/pro.4060   
2021 Falabella M, Vernon HJ, Hanna MG, Claypool SM, Pitceathly RDS. Cardiolipin, Mitochondria, and Neurological Disease. Trends in Endocrinology and Metabolism: Tem. PMID 33640250 DOI: 10.1016/j.tem.2021.01.006   
2021 Rübsamen N, Maceski A, Leppert D, Benkert P, Kuhle J, Wiendl H, Peters A, Karch A, Berger K. Serum neurofilament light and tau as prognostic markers for all-cause mortality in the elderly general population-an analysis from the MEMO study. Bmc Medicine. 19: 38. PMID 33583409 DOI: 10.1186/s12916-021-01915-8   
2021 Ju IG, Huh E, Kim N, Lee S, Choi JG, Hong J, Oh MS. Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 84: 153501. PMID 33626425 DOI: 10.1016/j.phymed.2021.153501   
2021 Bourgognon JM, Spiers JG, Robinson SW, Scheiblich H, Glynn P, Ortori C, Bradley SJ, Tobin AB, Steinert JR. Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33653950 DOI: 10.1073/pnas.2009579118   
2021 Maxwell SP, Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinical and neuropathological variability in the rare IVS10 + 14 tau mutation. Neurobiology of Aging. PMID 33612310 DOI: 10.1016/j.neurobiolaging.2021.01.004   
2021 Ungerleider K, Beck J, Lissa D, Turnquist C, Horikawa I, Harris BT, Harris CC. Astrocyte senescence and SASP in neurodegeneration: tau joins the loop. Cell Cycle (Georgetown, Tex.). 1-13. PMID 33818291 DOI: 10.1080/15384101.2021.1909260   
2021 Gelpi E, Aldecoa I, Lopez-Villegas D, Abellan-Vidal MT, Mercadel-Fañanas P, Fortea J, Roser R, Estrella M, Gomez-Anson B, Molina-Porcel L, Ximelis T, Borrego S, Antonell A, Rovelet-Lecrux A, Klotz S, et al. Atypical astroglial pTDP-43 pathology in astroglial predominant tauopathy. Neuropathology and Applied Neurobiology. PMID 33730418 DOI: 10.1111/nan.12707   
2021 Bachstetter AD, Garrett FG, Jicha GA, Nelson PT. Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review. Acta Neuropathologica Communications. 9: 49. PMID 33757579 DOI: 10.1186/s40478-021-01152-3   
2021 Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611   
2021 Moloney CM, Lowe VJ, Murray ME. Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33797838 DOI: 10.1002/alz.12321   
2021 Streubel-Gallasch L, Giusti V, Sandre M, Tessari I, Plotegher N, Giusto E, Masato A, Iovino L, Battisti I, Arrigoni G, Shimshek D, Greggio E, Tremblay ME, Bubacco L, Erlandsson A, et al. Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance. Molecular Neurobiology. PMID 33629273 DOI: 10.1007/s12035-021-02327-8   
2021 Thompson TB, Meisl G, Knowles TPJ, Goriely A. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of Chemical Physics. 154: 125101. PMID 33810689 DOI: 10.1063/5.0031650   
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011   
2021 Terracciano A, Aschwanden D, Stephan Y, Cerasa A, Passamonti L, Toschi N, Sutin AR. Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33817817 DOI: 10.1002/mds.28575   
2021 Wisessaowapak C, Visitnonthachai D, Watcharasit P, Satayavivad J. Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2. Environmental Toxicology and Pharmacology. 84: 103626. PMID 33621689 DOI: 10.1016/j.etap.2021.103626   
2021 Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of Aging. 103: 31-41. PMID 33789210 DOI: 10.1016/j.neurobiolaging.2021.02.025   
2021 Fiolek TJ, Keel KL, Tepe JJ. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. Acs Chemical Neuroscience. PMID 33788542 DOI: 10.1021/acschemneuro.1c00099   
2021 Xiao Y, Wang SK, Zhang Y, Rostami A, Kenkare A, Casella G, Yuan ZQ, Li X. Role of extracellular vesicles in neurodegenerative diseases. Progress in Neurobiology. 102022. PMID 33617919 DOI: 10.1016/j.pneurobio.2021.102022   
2021 Bi D, Xiao S, Lin Z, Yao L, Fang W, Wu Y, Xu H, Lu J, Xu X. Alginate-Derived Mannuronate Oligosaccharide Attenuates Tauopathy through Enhancing Autophagy. Journal of Agricultural and Food Chemistry. PMID 33829789 DOI: 10.1021/acs.jafc.1c00394   
2021 Pirie E, Oh CK, Zhang X, Han X, Cieplak P, Scott HR, Deal AK, Ghatak S, Martinez FJ, Yeo GW, Yates JR, Nakamura T, Lipton SA. S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33692125 DOI: 10.1073/pnas.2021368118