James H. Soper, Ph.D. - Related publications

2008 University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 He S, Wang F, Yung KKL, Zhang S, Qu S. Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease. Acs Chemical Neuroscience. PMID 33769791 DOI: 10.1021/acschemneuro.1c00028   
2021 Stojkovska I, Mazzulli JR. Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. Star Protocols. 2: 100372. PMID 33733241 DOI: 10.1016/j.xpro.2021.100372   
2021 Kwon OC, Song JJ, Yang Y, Kim SH, Kim JY, Seok MJ, Hwang I, Yu JW, Karmacharya J, Maeng HJ, Kim J, Jho EH, Ko SY, Son H, Chang MY, et al. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. Embo Molecular Medicine. e13076. PMID 33646633 DOI: 10.15252/emmm.202013076   
2021 Yan J, Ma H, Lai X, Wu J, Liu A, Huang J, Sun W, Shen M, Zhang Y. Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP-treated SH-SY5Y cells. Journal of Biological Research (Thessalonike, Greece). 28: 6. PMID 33632304 DOI: 10.1186/s40709-021-00137-6   
2021 Follett J, Farrer MJ. LRRK2; a dynamic regulator of cellular trafficking. Brain Research. 1761: 147394. PMID 33662339 DOI: 10.1016/j.brainres.2021.147394   
2021 Tavassoly O, Del Cid Pellitero E, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33713002 DOI: 10.1007/s13311-021-01017-6   
2021 Terracciano A, Aschwanden D, Stephan Y, Cerasa A, Passamonti L, Toschi N, Sutin AR. Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33817817 DOI: 10.1002/mds.28575   
2021 Ajoolabady A, Aslkhodapasandhokmabad H, Henninger N, Demillard LJ, Nikanfar M, Nourazarian A, Ren J. Targeting Autophagy in Neurodegenerative Diseases: from Molecular Mechanisms to Clinical Therapeutics. Clinical and Experimental Pharmacology & Physiology. PMID 33752254 DOI: 10.1111/1440-1681.13500   
2021 Falabella M, Vernon HJ, Hanna MG, Claypool SM, Pitceathly RDS. Cardiolipin, Mitochondria, and Neurological Disease. Trends in Endocrinology and Metabolism: Tem. PMID 33640250 DOI: 10.1016/j.tem.2021.01.006   
2021 Zhang Y, Li J, Zhang X, Song D, Tian T. Advances of Mechanisms-Related Metabolomics in Parkinson's Disease. Frontiers in Neuroscience. 15: 614251. PMID 33613180 DOI: 10.3389/fnins.2021.614251   
2021 Brás IC, Outeiro TF. Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies. Cells. 10. PMID 33673034 DOI: 10.3390/cells10020375   
2021 Tong Q, Chen L. Associations of Alzheimer's Disease Neuropathologic Changes with Clinical Presentations of Parkinson's Disease. Journal of Alzheimer's Disease : Jad. PMID 33720903 DOI: 10.3233/JAD-210114   
2021 Reyes JF, Ekmark-Léwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M. Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease. Acta Neuropathologica Communications. 9: 46. PMID 33743820 DOI: 10.1186/s40478-021-01136-3   
2021 Nam Y, Moon GJ, Kim SR. Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases. International Journal of Molecular Sciences. 22. PMID 33802760 DOI: 10.3390/ijms22063064   
2021 Pingale TD, Gupta GL. Novel therapeutic approaches for Parkinson's disease by targeting brain cholesterol homeostasis. The Journal of Pharmacy and Pharmacology. PMID 33822122 DOI: 10.1093/jpp/rgaa063   
2021 Streubel-Gallasch L, Giusti V, Sandre M, Tessari I, Plotegher N, Giusto E, Masato A, Iovino L, Battisti I, Arrigoni G, Shimshek D, Greggio E, Tremblay ME, Bubacco L, Erlandsson A, et al. Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance. Molecular Neurobiology. PMID 33629273 DOI: 10.1007/s12035-021-02327-8   
2021 Lee JH, Kim HJ, Kim JU, Yook TH, Kim KH, Lee JY, Yang G. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease. International Journal of Molecular Sciences. 22. PMID 33525754 DOI: 10.3390/ijms22031324   
2021 Xiao Y, Wang SK, Zhang Y, Rostami A, Kenkare A, Casella G, Yuan ZQ, Li X. Role of extracellular vesicles in neurodegenerative diseases. Progress in Neurobiology. 102022. PMID 33617919 DOI: 10.1016/j.pneurobio.2021.102022   
2021 Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY. LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons. Journal of Parkinson's Disease. PMID 33720852 DOI: 10.3233/JPD-212562   
2021 Chen HL, Chen PC, Lu CH, Tsai NW, Yu CC, Chou KH, Lai YR, Taoka T, Lin WC. Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease. Oxidative Medicine and Cellular Longevity. 2021: 4034509. PMID 33680283 DOI: 10.1155/2021/4034509   
2021 Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, et al. α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease. Jci Insight. 6. PMID 33682798 DOI: 10.1172/jci.insight.135633   
2021 Jiang C, Hopfner F, Berg D, Hu MT, Pilotto A, Borroni B, Davis JJ, Tofaris GK. Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33826157 DOI: 10.1002/mds.28591   
2021 Oh YS, Yoo SW, Lyoo CH, Yoo JY, Yoon H, Ha S, Lee KS, Kim JS. The Association of β-Amyloid with Cognition and Striatal Dopamine in Early, Non-Demented Parkinson's Disease. Journal of Parkinson's Disease. PMID 33646180 DOI: 10.3233/JPD-202496   
2021 Shill HA, Zhang N, Driver-Dunckley E, Mehta S, Adler CH, Beach TG. Olfaction in Neuropathologically Defined Progressive Supranuclear Palsy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33755262 DOI: 10.1002/mds.28568   
2021 Ju IG, Huh E, Kim N, Lee S, Choi JG, Hong J, Oh MS. Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 84: 153501. PMID 33626425 DOI: 10.1016/j.phymed.2021.153501   
2021 Adams JL, Lizarraga KJ, Waddell EM, Myers TL, Jensen-Roberts S, Modica JS, Schneider RB. Digital Technology in Movement Disorders: Updates, Applications, and Challenges. Current Neurology and Neuroscience Reports. 21: 16. PMID 33660110 DOI: 10.1007/s11910-021-01101-6   
2021 Qin LX, Tan JQ, Zhang HN, Tang JG, Jiang B, Shen XM, Guo JF, Tan LM, Tang B, Wang CY. Preliminary Study of hsa-mir-626 Change in the Cerebrospinal Fluid in Parkinson's Disease. Neurology India. 69: 115-118. PMID 33642281 DOI: 10.4103/0028-3886.310102   
2021 Tran SM, Mohajeri MH. The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease. Nutrients. 13. PMID 33669008 DOI: 10.3390/nu13030732   
2021 Girges C, Vijiaratnam N, Athauda D, Auld G, Gandhi S, Foltynie T. The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability. Drugs & Aging. PMID 33738783 DOI: 10.1007/s40266-021-00853-7   
2021 Ravanfar P, Loi SM, Syeda WT, Van Rheenen TE, Bush AI, Desmond P, Cropley VL, Lane DJR, Opazo CM, Moffat BA, Velakoulis D, Pantelis C. Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases. Frontiers in Neuroscience. 15: 618435. PMID 33679303 DOI: 10.3389/fnins.2021.618435   
2021 Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F. SGTA associates with intracellular aggregates in neurodegenerative diseases. Molecular Brain. 14: 59. PMID 33757575 DOI: 10.1186/s13041-021-00770-1   
2021 Roshanbin S, Aniszewska A, Gumucio A, Masliah E, Erlandsson A, Bergström J, Ingelsson M, Ekmark-Lewén S. Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice. Neurobiology of Aging. 101: 207-220. PMID 33639338 DOI: 10.1016/j.neurobiolaging.2021.01.010   
2021 Gu H, Yang X, Mao X, Xu E, Qi C, Wang H, Brahmachari S, York B, Sriparna M, Li A, Chang M, Patel P, Dawson VL, Dawson TM. Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice. Frontiers in Cellular Neuroscience. 15: 656426. PMID 33776654 DOI: 10.3389/fncel.2021.656426   
2021 Kawakami I, Motoda A, Hashimoto M, Shimozawa A, Masuda-Suzukake M, Ohtani R, Takase M, Kumashiro M, Samejima K, Hasegawa M. Progression of phosphorylated α-synuclein in Macaca fuscata. Brain Pathology (Zurich, Switzerland). e12952. PMID 33754430 DOI: 10.1111/bpa.12952   
2021 Shafiq K, Sanghai N, Guo Y, Kong J. Implication of post-translationally modified SOD1 in pathological aging. Geroscience. PMID 33608813 DOI: 10.1007/s11357-021-00332-2   
2021 Wei J, Takamatsu Y, Wada R, Fujita M, Ho G, Masliah E, Hashimoto M. Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease. Biomolecules. 11. PMID 33672048 DOI: 10.3390/biom11020289   
2021 Fiolek TJ, Keel KL, Tepe JJ. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. Acs Chemical Neuroscience. PMID 33788542 DOI: 10.1021/acschemneuro.1c00099   
2021 Antunes ASLM, de Almeida V, Crunfli F, Carregari VC, Martins-de-Souza D. Proteomics for Target Identification in Psychiatric and Neurodegenerative Disorders. Advances in Experimental Medicine and Biology. 1286: 251-264. PMID 33725358 DOI: 10.1007/978-3-030-55035-6_17   
2021 Dion C, Frank BE, Crowley SJ, Hizel LP, Rodriguez K, Tanner J, Libon DJ, Price CC. Parkinson's Disease Cognitive Phenotypes Show Unique Clock Drawing Features when Measured with Digital Technology. Journal of Parkinson's Disease. PMID 33682726 DOI: 10.3233/JPD-202399   
2021 Li X, Yu Y, Tu Z. Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020). Molecules (Basel, Switzerland). 26. PMID 33668128 DOI: 10.3390/molecules26051202   
2021 Baik K, Yang JJ, Jung JH, Lee YH, Chung SJ, Yoo HS, Sohn YH, Lee PH, Lee JM, Ye BS. Structural connectivity networks in Alzheimer's disease and Lewy body disease. Brain and Behavior. e02112. PMID 33792194 DOI: 10.1002/brb3.2112   
2021 Baik K, Yang JJ, Jung JH, Lee YH, Chung SJ, Yoo HS, Sohn YH, Lee PH, Lee JM, Ye BS. Structural connectivity networks in Alzheimer's disease and Lewy body disease. Brain and Behavior. e02112. PMID 33792194 DOI: 10.1002/brb3.2112   
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011   
2021 Holbrook JA, Jarosz-Griffiths HH, Caseley E, Lara-Reyna S, Poulter JA, Williams-Gray CH, Peckham D, McDermott MF. Neurodegenerative Disease and the NLRP3 Inflammasome. Frontiers in Pharmacology. 12: 643254. PMID 33776778 DOI: 10.3389/fphar.2021.643254   
2021 Riley EA, Schekman R. Open science takes on Parkinson's disease. Elife. 10. PMID 33629954 DOI: 10.7554/eLife.66546   
2021 Khatua P, Jana AK, Hansmann UHE. Effect of Lauric Acid on the Stability of Aβ Oligomers. Acs Omega. 6: 5795-5804. PMID 33681618 DOI: 10.1021/acsomega.0c06211   
2021 Wells C, Brennan S, Keon M, Ooi L. The role of amyloid oligomers in neurodegenerative pathologies. International Journal of Biological Macromolecules. PMID 33766600 DOI: 10.1016/j.ijbiomac.2021.03.113   
2021 Kim R, Park S, Yoo D, Jun JS, Jeon B. Association of Physical Activity and Genotype With Longitudinal Cognitive Change in Early PD. Neurology. PMID 33790041 DOI: 10.1212/WNL.0000000000011852   
2021 Root J, Merino P, Nuckols A, Johnson M, Kukar T. Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiology of Disease. 105360. PMID 33812000 DOI: 10.1016/j.nbd.2021.105360   
2021 Teli P, Sahiba N, Soni J, Sethiya A, Agarwal DK, Agarwal S. Exploration of Potent Multi-Target-Directed-Ligands as Anti-Alzheimer's Disease Agents: A Moiety Based Review. Mini Reviews in Medicinal Chemistry. PMID 33663363 DOI: 10.2174/1389557521666210304111754