David E. Hurtado, Ph.D. - Related publications

2011 University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Carlomagno Y, Manne S, DeTure M, Prudencio M, Zhang YJ, Hanna Al-Shaikh R, Dunmore JA, Daughrity LM, Song Y, Castanedes-Casey M, Lewis-Tuffin LJ, Nicholson KA, Wszolek ZK, Dickson DW, Fitzpatrick AWP, et al. The AD tau core spontaneously self-assembles and recruits full-length tau to filaments. Cell Reports. 34: 108843. PMID 33730588 DOI: 10.1016/j.celrep.2021.108843   
2021 Li L, Shi R, Gu J, Tung YC, Zhou Y, Zhou D, Wu R, Chu D, Jin N, Deng K, Xu J, Gong CX, Iqbal K, Liu F. Alzheimer's disease brain contains tau fractions with differential prion-like activities. Acta Neuropathologica Communications. 9: 28. PMID 33597014 DOI: 10.1186/s40478-021-01127-4   
2021 Tarutani A, Miyata H, Nonaka T, Hasegawa K, Yoshida M, Saito Y, Murayama S, Robinson AC, Mann DMA, Tomita T, Hasegawa M. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a Journal of Neurology. PMID 33693528 DOI: 10.1093/brain/awab091   
2021 Lathuiliere A, Hyman BT. Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids. Frontiers in Neuroscience. 15: 654176. PMID 33828458 DOI: 10.3389/fnins.2021.654176   
2021 Pan D, Gu JH, Zhang J, Hu Y, Liu F, Iqbal K, Cekic N, Vocadlo DJ, Dai CL, Gong CX. Thiamme2-G, A Novel O-GlcNAcase Inhibitor, Reduces Tau Hyperphosphorylation and Rescues Cognitive Impairment in Mice. Journal of Alzheimer's Disease : Jad. PMID 33814439 DOI: 10.3233/JAD-201450   
2021 Soares AC, Ferreira A, Mariën J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynck L. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. The Journal of Biological Chemistry. 100636. PMID 33831417 DOI: 10.1016/j.jbc.2021.100636   
2021 Mueller RL, Combs B, Alhadidy MM, Brady ST, Morfini GA, Kanaan NM. Tau: A Signaling Hub Protein. Frontiers in Molecular Neuroscience. 14: 647054. PMID 33815057 DOI: 10.3389/fnmol.2021.647054   
2021 McMurray L, Macdonald JA, Ramakrishnan NK, Zhao Y, Williamson DW, Tietz O, Zhou X, Kealey S, Fagan SG, Smolek T, Cubinkova V, Žilka N, Spillantini MG, Tolkovsky AM, Goedert M, et al. Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models. Acs Chemical Neuroscience. PMID 33689290 DOI: 10.1021/acschemneuro.0c00790   
2021 Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, et al. Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathologica Communications. 9: 38. PMID 33750467 DOI: 10.1186/s40478-021-01138-1   
2021 Song L, Wells EA, Robinson AS. Critical Molecular and Cellular Contributors to Tau Pathology. Biomedicines. 9. PMID 33672982 DOI: 10.3390/biomedicines9020190   
2021 Darling AL, Dahrendorff J, Creodore SG, Dickey CA, Blair LJ, Uversky VN. Small heat shock protein 22kDa can modulate the aggregation and liquid-liquid phase separation behavior of Tau. Protein Science : a Publication of the Protein Society. PMID 33686711 DOI: 10.1002/pro.4060   
2021 Vasconcelos IC, Campos RM, Schwaemmle HM, Masson AP, Ferrari GD, Alberici LC, Faça VM, Garcia-Cairasco N, Sebollela A. A freeze-and-thaw induced-fragment of the microtubule-associated protein Tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity. Bioscience Reports. PMID 33629708 DOI: 10.1042/BSR20203980   
2021 Shin J, Yang SH, Du YE, Park K, Kim D, Shin D, Kim J, Kim SH, Kim YK, Shin J, Oh DC, Kim Y. Borrelidin from Saltern-Derived Halophilic sp. Dissociates Amyloid- and Tau Fibrils. Journal of Alzheimer's Disease Reports. 5: 7-13. PMID 33681712 DOI: 10.3233/ADR-200247   
2021 Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611   
2021 Ding XL, Tuo QZ, Lei P. An Introduction to Ultrasensitive Assays for Plasma Tau Detection. Journal of Alzheimer's Disease : Jad. PMID 33682718 DOI: 10.3233/JAD-201499   
2021 Adams JN, Maass A, Berron D, Harrison TM, Baker SL, Thomas WP, Stanfill M, Jagust WJ. Reduced repetition suppression in aging is driven by tau-related hyperactivity in medial temporal lobe. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33731446 DOI: 10.1523/JNEUROSCI.2504-20.2021   
2021 Xiao S, Lu Y, Wu Q, Yang J, Chen J, Zhong S, Eliezer D, Tan Q, Wu C. Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International Journal of Biological Macromolecules. PMID 33662414 DOI: 10.1016/j.ijbiomac.2021.02.210   
2021 Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA. Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathologica Communications. 9: 41. PMID 33712082 DOI: 10.1186/s40478-021-01141-6   
2021 Yap SY, Frias B, Wren MC, Schöll M, Fox NC, Årstad E, Lashley T, Sander K. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a Journal of Neurology. PMID 33742656 DOI: 10.1093/brain/awab120   
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9   
2021 Bajracharya R, Brici D, Bodea LG, Janowicz PW, Götz J, Nisbet RM. Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Acta Neuropathologica Communications. 9: 42. PMID 33712083 DOI: 10.1186/s40478-021-01147-0   
2021 Hao J, Tang Y, Liu X, Yao E. Inhibiting PI3K leads to glucose metabolism disturbance in default mode network. Brain Research Bulletin. PMID 33626336 DOI: 10.1016/j.brainresbull.2021.02.020   
2021 Devous MD, Fleisher AS, Pontecorvo MJ, Lu M, Siderowf A, Navitsky M, Kennedy I, Southekal S, Harris TS, Mintun MA. Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET. Journal of Alzheimer's Disease : Jad. PMID 33682705 DOI: 10.3233/JAD-200808   
2021 Ding X, Zhang S, Jiang L, Wang L, Li T, Lei P. Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease: a systematic review and meta-analysis. Translational Neurodegeneration. 10: 10. PMID 33712071 DOI: 10.1186/s40035-021-00234-5   
2021 Leonard C, Phillips C, McCarty J. Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer's Disease Protofibril Core. Frontiers in Molecular Biosciences. 8: 624302. PMID 33816551 DOI: 10.3389/fmolb.2021.624302   
2021 Criado-Marrero M, Gebru NT, Blazier DM, Gould LA, Baker JD, Beaulieu-Abdelahad D, Blair LJ. Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. Acta Neuropathologica Communications. 9: 65. PMID 33832539 DOI: 10.1186/s40478-021-01159-w   
2021 Kim S, Kim K, Nho K, Myung W, Won HH. Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. Journal of Alzheimer's Disease : Jad. PMID 33646147 DOI: 10.3233/JAD-200671   
2021 Khodarahmi R, Akbari V, Mohammadi S, Farshadnia T, Rahimabadi MM, Goicoechea HC, Jalalvand AR. Chemometric modeling of the electrochemical data to investigate proline cis/trans isomeration effect on aggregation of Tau protein. Protein Expression and Purification. 182: 105858. PMID 33639278 DOI: 10.1016/j.pep.2021.105858   
2021 Chang CW, Shao E, Mucke L. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). 371. PMID 33632820 DOI: 10.1126/science.abb8255   
2021 Suire CN, Leissring MA. Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease. Journal of Experimental Neurology. 2: 10-15. PMID 33665647   
2021 Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, et al. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619090 DOI: 10.1073/pnas.2014188118   
2021 Friedrich MG, Skora A, Hancock SE, Mitchell TW, Else PL, Truscott RJW. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International Journal of Molecular Sciences. 22. PMID 33805376 DOI: 10.3390/ijms22073521   
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w   
2021 Gelpi E, Aldecoa I, Lopez-Villegas D, Abellan-Vidal MT, Mercadel-Fañanas P, Fortea J, Roser R, Estrella M, Gomez-Anson B, Molina-Porcel L, Ximelis T, Borrego S, Antonell A, Rovelet-Lecrux A, Klotz S, et al. Atypical astroglial pTDP-43 pathology in astroglial predominant tauopathy. Neuropathology and Applied Neurobiology. PMID 33730418 DOI: 10.1111/nan.12707   
2021 Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM. Alzheimer's disease. Lancet (London, England). PMID 33667416 DOI: 10.1016/S0140-6736(20)32205-4   
2021 Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M, Ling D. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. Acs Nano. PMID 33683854 DOI: 10.1021/acsnano.0c10690   
2021 Klein J, Yan X, Johnson A, Tomljanovic Z, Zou J, Polly K, Honig LS, Brickman AM, Stern Y, Devanand DP, Lee S, Kreisl WC. Olfactory Impairment is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33646153 DOI: 10.3233/JAD-201149   
2021 Wisessaowapak C, Visitnonthachai D, Watcharasit P, Satayavivad J. Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2. Environmental Toxicology and Pharmacology. 84: 103626. PMID 33621689 DOI: 10.1016/j.etap.2021.103626   
2021 Xu M, Lu M, Zhang W, Jin Q, Chen Y. Simultaneous Detection of Six Isoforms of Tau Protein in Human Cerebrospinal Fluid by Multidimensional Mass Spectrometry-Based Targeted Proteomics. Journal of Proteome Research. PMID 33843226 DOI: 10.1021/acs.jproteome.0c00826   
2021 Martellucci S, Clementi L, Sabetta S, Muzi P, Mattei V, Bologna M, Angelucci A. Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment. Journal of Cancer Research and Clinical Oncology. PMID 33811272 DOI: 10.1007/s00432-021-03598-3   
2021 Xia Y, Nasif L, Giasson BI. Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction. Journal of Neurochemistry. PMID 33772783 DOI: 10.1111/jnc.15358   
2021 Ahmad SS, Khalid M, Kamal MA, Younis K. Study of Nutraceuticals and Phytochemicals for the Management of Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 33588732 DOI: 10.2174/1570159X19666210215122333   
2021 Lee SH, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, Rezzonico MG, Imperio J, Lalehzadeh G, Huntley MA, Stark KL, Foreman O, Carano RAD, Friedman BA, Sheng M, et al. Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology. Neuron. PMID 33675684 DOI: 10.1016/j.neuron.2021.02.010   
2021 Gaudreault R, Hervé V, van de Ven TGM, Mousseau N, Ramassamy C. Polyphenol-Peptide Interactions in Mitigation of Alzheimer's Disease: Role of Biosurface-Induced Aggregation. Journal of Alzheimer's Disease : Jad. PMID 33749653 DOI: 10.3233/JAD-201549   
2021 Moloney CM, Lowe VJ, Murray ME. Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33797838 DOI: 10.1002/alz.12321   
2021 Chiu MJ, Yang SY, Chen TF, Lin CH, Yang FC, Chen WP, Zetterberg H, Blennow K. Synergistic Association between Plasma Aβ and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia. Acs Chemical Neuroscience. PMID 33825443 DOI: 10.1021/acschemneuro.1c00010   
2021 Prikas E, Ahel H, Stefanoska K, Asih PR, Volkerling A, Ittner LM, Ittner A. Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 33794133 DOI: 10.1139/bcb-2020-0604   
2021 Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of Aging. 103: 31-41. PMID 33789210 DOI: 10.1016/j.neurobiolaging.2021.02.025   
2021 Yu D, Yin Q, Wang J, Yang J, Chen Z, Gao Z, Huang Q, Li S. SERS-Based Immunoassay Enhanced with Silver Probe for Selective Separation and Detection of Alzheimer's Disease Biomarkers. International Journal of Nanomedicine. 16: 1901-1911. PMID 33707945 DOI: 10.2147/IJN.S293042   
2021 Schoemaker D, Charidimou A, Zanon Zotin MC, Raposo N, Johnson KA, Sanchez JS, Greenberg SM, Viswanathan A. Association of Memory Impairment with Concomitant Tau Pathology in Patients with Cerebral Amyloid Angiopathy. Neurology. PMID 33627498 DOI: 10.1212/WNL.0000000000011745