Selcuk A. Tanik, Ph.D. - Related publications

2013 Biology University of Pennsylvania, Philadelphia, PA, United States 
tau, dementia, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Stojkovska I, Mazzulli JR. Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. Star Protocols. 2: 100372. PMID 33733241 DOI: 10.1016/j.xpro.2021.100372   
2021 Tavassoly O, Del Cid Pellitero E, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33713002 DOI: 10.1007/s13311-021-01017-6   
2021 Ajoolabady A, Aslkhodapasandhokmabad H, Henninger N, Demillard LJ, Nikanfar M, Nourazarian A, Ren J. Targeting Autophagy in Neurodegenerative Diseases: from Molecular Mechanisms to Clinical Therapeutics. Clinical and Experimental Pharmacology & Physiology. PMID 33752254 DOI: 10.1111/1440-1681.13500   
2021 Follett J, Farrer MJ. LRRK2; a dynamic regulator of cellular trafficking. Brain Research. 1761: 147394. PMID 33662339 DOI: 10.1016/j.brainres.2021.147394   
2021 He S, Wang F, Yung KKL, Zhang S, Qu S. Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease. Acs Chemical Neuroscience. PMID 33769791 DOI: 10.1021/acschemneuro.1c00028   
2021 Wulansari N, Darsono WHW, Woo HJ, Chang MY, Kim J, Bae EJ, Sun W, Lee JH, Cho IJ, Shin H, Lee SJ, Lee SH. Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked mutations. Science Advances. 7. PMID 33597231 DOI: 10.1126/sciadv.abb1540   
2021 Kwon OC, Song JJ, Yang Y, Kim SH, Kim JY, Seok MJ, Hwang I, Yu JW, Karmacharya J, Maeng HJ, Kim J, Jho EH, Ko SY, Son H, Chang MY, et al. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. Embo Molecular Medicine. e13076. PMID 33646633 DOI: 10.15252/emmm.202013076   
2021 Jin JW, Fan X, Del Cid-Pellitero E, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, et al. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Communications Biology. 4: 232. PMID 33608634 DOI: 10.1038/s42003-021-01746-6   
2021 Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F. SGTA associates with intracellular aggregates in neurodegenerative diseases. Molecular Brain. 14: 59. PMID 33757575 DOI: 10.1186/s13041-021-00770-1   
2021 Brás IC, Outeiro TF. Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies. Cells. 10. PMID 33673034 DOI: 10.3390/cells10020375   
2021 Nam Y, Moon GJ, Kim SR. Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases. International Journal of Molecular Sciences. 22. PMID 33802760 DOI: 10.3390/ijms22063064   
2021 Dhakal S, Wyant CE, George HE, Morgan SE, Rangachari V. Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils. Journal of Molecular Biology. 166953. PMID 33771571 DOI: 10.1016/j.jmb.2021.166953   
2021 Thompson TB, Meisl G, Knowles TPJ, Goriely A. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of Chemical Physics. 154: 125101. PMID 33810689 DOI: 10.1063/5.0031650   
2021 Yan J, Ma H, Lai X, Wu J, Liu A, Huang J, Sun W, Shen M, Zhang Y. Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP-treated SH-SY5Y cells. Journal of Biological Research (Thessalonike, Greece). 28: 6. PMID 33632304 DOI: 10.1186/s40709-021-00137-6   
2021 Song L, Wells EA, Robinson AS. Critical Molecular and Cellular Contributors to Tau Pathology. Biomedicines. 9. PMID 33672982 DOI: 10.3390/biomedicines9020190   
2021 Jiang C, Hopfner F, Berg D, Hu MT, Pilotto A, Borroni B, Davis JJ, Tofaris GK. Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33826157 DOI: 10.1002/mds.28591   
2021 Fiolek TJ, Keel KL, Tepe JJ. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. Acs Chemical Neuroscience. PMID 33788542 DOI: 10.1021/acschemneuro.1c00099   
2021 Wells C, Brennan S, Keon M, Ooi L. The role of amyloid oligomers in neurodegenerative pathologies. International Journal of Biological Macromolecules. PMID 33766600 DOI: 10.1016/j.ijbiomac.2021.03.113   
2021 Streubel-Gallasch L, Giusti V, Sandre M, Tessari I, Plotegher N, Giusto E, Masato A, Iovino L, Battisti I, Arrigoni G, Shimshek D, Greggio E, Tremblay ME, Bubacco L, Erlandsson A, et al. Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance. Molecular Neurobiology. PMID 33629273 DOI: 10.1007/s12035-021-02327-8   
2021 Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nature Structural & Molecular Biology. PMID 33767451 DOI: 10.1038/s41594-021-00565-x   
2021 Kim C, Kwon S, Iba M, Spencer B, Rockenstein E, Mante M, Adame A, Shin SJ, Fields JA, Rissman RA, Lee SJ, Masliah E. Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells. Experimental & Molecular Medicine. PMID 33594256 DOI: 10.1038/s12276-021-00562-6   
2021 Pan Q, Ban Y, Khan S. Antioxidant activity of calycosin against α-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson's disease. International Journal of Biological Macromolecules. PMID 33798579 DOI: 10.1016/j.ijbiomac.2021.03.186   
2021 Akter R, Rahman MH, Behl T, Chowdhury MAR, Manirujjaman M, Bulbul IJ, Elshenaw SE, Tit DM, Bungau S. Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases. Cns & Neurological Disorders Drug Targets. PMID 33602109 DOI: 10.2174/1871527320666210218084444   
2021 Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY. LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons. Journal of Parkinson's Disease. PMID 33720852 DOI: 10.3233/JPD-212562   
2021 Terracciano A, Aschwanden D, Stephan Y, Cerasa A, Passamonti L, Toschi N, Sutin AR. Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33817817 DOI: 10.1002/mds.28575   
2021 Kumari P, Ghosh D, Vanas A, Fleischmann Y, Wiegand T, Jeschke G, Riek R, Eichmann C. Structural insights into α-synuclein monomer-fibril interactions. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33649211 DOI: 10.1073/pnas.2012171118   
2021 Chen X, Zhang Y, Wang Q, Qin Y, Yang X, Xing Z, Shen Y, Wu H, Qi Y. The function of SUMOylation and its crucial roles in the development of neurological diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21510. PMID 33710677 DOI: 10.1096/fj.202002702R   
2021 Liu X, Yin L, Li T, Lin L, Zhang J, Li Y. Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes. Plos Genetics. 17: e1009415. PMID 33730050 DOI: 10.1371/journal.pgen.1009415   
2021 Singh A, Agrawal N. Deciphering the key mechanisms leading to alteration of lipid metabolism in Drosophila model of Huntington's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166127. PMID 33722743 DOI: 10.1016/j.bbadis.2021.166127   
2021 Psol M, Darvas SG, Leite K, Mahajani SU, Bähr M, Kügler S. Dementia with Lewy bodies-associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions. Human Molecular Genetics. PMID 33760043 DOI: 10.1093/hmg/ddab036   
2021 Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB. Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience. 13: 635760. PMID 33828477 DOI: 10.3389/fnagi.2021.635760   
2021 Pirie E, Oh CK, Zhang X, Han X, Cieplak P, Scott HR, Deal AK, Ghatak S, Martinez FJ, Yeo GW, Yates JR, Nakamura T, Lipton SA. S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33692125 DOI: 10.1073/pnas.2021368118   
2021 Ju IG, Huh E, Kim N, Lee S, Choi JG, Hong J, Oh MS. Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 84: 153501. PMID 33626425 DOI: 10.1016/j.phymed.2021.153501   
2021 Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, et al. α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease. Jci Insight. 6. PMID 33682798 DOI: 10.1172/jci.insight.135633   
2021 Xing J, Xu C. Role of connexins in neurodegenerative diseases (Review). Molecular Medicine Reports. 23. PMID 33760195 DOI: 10.3892/mmr.2021.12034   
2021 Kawakami I, Motoda A, Hashimoto M, Shimozawa A, Masuda-Suzukake M, Ohtani R, Takase M, Kumashiro M, Samejima K, Hasegawa M. Progression of phosphorylated α-synuclein in Macaca fuscata. Brain Pathology (Zurich, Switzerland). e12952. PMID 33754430 DOI: 10.1111/bpa.12952   
2021 Rahul, Siddique YH. Neurodegenerative diseases and Flavonoids: Special reference to kaempferol. Cns & Neurological Disorders Drug Targets. PMID 33511932 DOI: 10.2174/1871527320666210129122033   
2021 Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey BW, Radford SE, Jat P, Collinge J, Bieschke J. Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium. Journal of Molecular Biology. 166878. PMID 33610557 DOI: 10.1016/j.jmb.2021.166878   
2021 Holbrook JA, Jarosz-Griffiths HH, Caseley E, Lara-Reyna S, Poulter JA, Williams-Gray CH, Peckham D, McDermott MF. Neurodegenerative Disease and the NLRP3 Inflammasome. Frontiers in Pharmacology. 12: 643254. PMID 33776778 DOI: 10.3389/fphar.2021.643254   
2021 Lee JH, Kim HJ, Kim JU, Yook TH, Kim KH, Lee JY, Yang G. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease. International Journal of Molecular Sciences. 22. PMID 33525754 DOI: 10.3390/ijms22031324   
2021 Shill HA, Zhang N, Driver-Dunckley E, Mehta S, Adler CH, Beach TG. Olfaction in Neuropathologically Defined Progressive Supranuclear Palsy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33755262 DOI: 10.1002/mds.28568   
2021 Reyes JF, Ekmark-Léwen S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, Nilsson P, Nilsson KPR, Alafuzoff I, Ingelsson M, Hallbeck M. Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease. Acta Neuropathologica Communications. 9: 46. PMID 33743820 DOI: 10.1186/s40478-021-01136-3   
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9   
2021 Xiao Y, Wang SK, Zhang Y, Rostami A, Kenkare A, Casella G, Yuan ZQ, Li X. Role of extracellular vesicles in neurodegenerative diseases. Progress in Neurobiology. 102022. PMID 33617919 DOI: 10.1016/j.pneurobio.2021.102022   
2021 Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, et al. Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity. Genome Biology. 22: 73. PMID 33663567 DOI: 10.1186/s13059-021-02301-6   
2021 Gu H, Yang X, Mao X, Xu E, Qi C, Wang H, Brahmachari S, York B, Sriparna M, Li A, Chang M, Patel P, Dawson VL, Dawson TM. Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice. Frontiers in Cellular Neuroscience. 15: 656426. PMID 33776654 DOI: 10.3389/fncel.2021.656426   
2021 Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M, Ling D. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. Acs Nano. PMID 33683854 DOI: 10.1021/acsnano.0c10690   
2021 Root J, Merino P, Nuckols A, Johnson M, Kukar T. Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiology of Disease. 105360. PMID 33812000 DOI: 10.1016/j.nbd.2021.105360   
2021 Paulus A, Engdahl A, Yang Y, Boza-Serrano A, Bachiller S, Torres-Garcia L, Svanbergsson A, Garcia MG, Gouras GK, Li JY, Deierborg T, Klementieva O. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33810433 DOI: 10.3390/ijms22073430   
2021 Zhang Y, Li J, Zhang X, Song D, Tian T. Advances of Mechanisms-Related Metabolomics in Parkinson's Disease. Frontiers in Neuroscience. 15: 614251. PMID 33613180 DOI: 10.3389/fnins.2021.614251