Joshua P. Thaler, Ph.D. - Publications

Affiliations: 
2001 University of California, San Diego, La Jolla, CA 
Area:
Development

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG, Schwartz MW, Morton GJ. Functional identification of a neurocircuit regulating blood glucose. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001850 DOI: 10.1073/pnas.1521160113  0.68
2015 Dorfman MD, Thaler JP. Hypothalamic inflammation and gliosis in obesity. Current Opinion in Endocrinology, Diabetes, and Obesity. 22: 325-30. PMID 26192704 DOI: 10.1097/MED.0000000000000182  0.68
2014 Berkseth KE, Guyenet SJ, Melhorn SJ, Lee D, Thaler JP, Schur EA, Schwartz MW. Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology. 155: 2858-67. PMID 24914942 DOI: 10.1210/en.2014-1121  0.68
2014 Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, et al. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia. 62: 17-25. PMID 24166765 DOI: 10.1002/glia.22580  0.68
2013 Karatsoreos IN, Thaler JP, Borgland SL, Champagne FA, Hurd YL, Hill MN. Food for thought: hormonal, experiential, and neural influences on feeding and obesity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17610-6. PMID 24198352 DOI: 10.1523/JNEUROSCI.3452-13.2013  0.68
2013 Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes. 62: 2629-34. PMID 23881189 DOI: 10.2337/db12-1605  0.68
2013 Lee D, Thaler JP, Berkseth KE, Melhorn SJ, Schwartz MW, Schur EA. Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. American Journal of Physiology. Endocrinology and Metabolism. 304: E1245-50. PMID 23548614 DOI: 10.1152/ajpendo.00020.2013  0.68
2013 Guyenet SJ, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP. High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Research. 1512: 97-105. PMID 23548599 DOI: 10.1016/j.brainres.2013.03.033  0.68
2013 Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ. In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. American Journal of Physiology. Endocrinology and Metabolism. 304: E734-46. PMID 23384771 DOI: 10.1152/ajpendo.00488.2012  0.68
2013 Meek TH, Wisse BE, Thaler JP, Guyenet SJ, Matsen ME, Fischer JD, Taborsky GJ, Schwartz MW, Morton GJ. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes. 62: 1512-8. PMID 23274899 DOI: 10.2337/db12-0837  0.68
2012 Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE. Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. Plos One. 7: e41473. PMID 22936977 DOI: 10.1371/journal.pone.0041473  0.68
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, et al. Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation. 122: 153-62. PMID 22201683 DOI: 10.1172/JCI59660  0.68
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, et al. Obesity is associated with hypothalamic injury in rodents and humans (The Journal of Clinical Investigation (2012) 122, 1, (153-162) DOI: 10.1172/JCI59660) Journal of Clinical Investigation. 122: 778. DOI: 10.1172/JCI62813  0.68
2011 German JP, Thaler JP, Wisse BE, Oh-I S, Sarruf DA, Matsen ME, Fischer JD, Taborsky GJ, Schwartz MW, Morton GJ. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology. 152: 394-404. PMID 21159853 DOI: 10.1210/en.2010-0890  0.68
2010 Thaler JP, Schwartz MW. Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology. 151: 4109-15. PMID 20573720 DOI: 10.1210/en.2010-0336  0.68
2010 German JP, Wisse BE, Thaler JP, Oh-I S, Sarruf DA, Ogimoto K, Kaiyala KJ, Fischer JD, Matsen ME, Taborsky GJ, Schwartz MW, Morton GJ. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 59: 1626-34. PMID 20424233 DOI: 10.2337/db09-1918  0.68
2010 Oh-I S, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, Schwartz MW. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. American Journal of Physiology. Endocrinology and Metabolism. 299: E47-53. PMID 20371733 DOI: 10.1152/ajpendo.00026.2010  0.68
2010 Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes. 59: 1817-24. PMID 20357365 DOI: 10.2337/db09-1878  0.68
2010 Thaler JP, Choi SJ, Schwartz MW, Wisse BE. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Frontiers in Neuroendocrinology. 31: 79-84. PMID 19822168 DOI: 10.1016/j.yfrne.2009.10.002  0.68
2009 Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW. Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology. 150: 5362-72. PMID 19819945 DOI: 10.1210/en.2009-0509  0.68
2009 Thaler JP, Cummings DE. Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology. 150: 2518-25. PMID 19372197 DOI: 10.1210/en.2009-0367  0.68
2008 Thaler JP, Cummings DE. Metabolism: food alert. Nature. 452: 941-2. PMID 18432230 DOI: 10.1038/452941a  0.68
2008 Ghosh S, Marquardt T, Thaler JP, Carter N, Andrews SE, Pfaff SL, Hunter T. Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proceedings of the National Academy of Sciences of the United States of America. 105: 335-40. PMID 18162555 DOI: 10.1073/pnas.0705713105  0.68
2007 Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circulation Research. 100: 1589-96. PMID 17478729 DOI: 10.1161/CIRCRESAHA.106.142851  0.68
2005 Mizutani A, Wang L, Rajan H, Vig PJ, Alaynick WA, Thaler JP, Tsai CC. Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. The Embo Journal. 24: 3339-51. PMID 16121196 DOI: 10.1038/sj.emboj.7600785  0.68
2004 Thaler JP, Koo SJ, Kania A, Lettieri K, Andrews S, Cox C, Jessell TM, Pfaff SL. A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 41: 337-50. PMID 14766174 DOI: 10.1016/S0896-6273(04)00011-X  0.68
2002 Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell. 110: 237-49. PMID 12150931 DOI: 10.1016/S0092-8674(02)00823-1  0.68
1999 Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J, Pfaff SL. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron. 23: 675-87. PMID 10482235 DOI: 10.1016/S0896-6273(01)80027-1  0.68
1999 Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nature Genetics. 23: 71-5. PMID 10471502 DOI: 10.1038/12674  0.68
1993 Stewart RJ, Thaler JP, Goldstein LS. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein. Proceedings of the National Academy of Sciences of the United States of America. 90: 5209-13. PMID 8506368  0.68
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