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Joshua P. Thaler, Ph.D. - Publications

Affiliations: 
2001 University of California, San Diego, La Jolla, CA 
Area:
Development
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34/44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Banerjee J, Dorfman MD, Fasnacht R, Douglass JD, Wyse-Jackson AC, Barria A, Thaler JP. CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding. International Journal of Molecular Sciences. 23. PMID 35742824 DOI: 10.3390/ijms23126380  0.337
2020 Dorfman MD, Frey J, Ness KM, Niraula A, Kanter JE, Bornfeldt K, Rubinow K, Schur E, Thaler J. 212-OR: Testosterone Deficiency Increases Hypothalamic Gliosis and Metabolic Risk Diabetes. 69. DOI: 10.2337/Db20-212-Or  0.368
2020 Niraula A, Fasnacht R, Ness KM, Frey J, Dorfman MD, Thaler J. 1759-P: Prostaglandin PGE2 Receptor EP4 Signaling Deficiency in Microglia Reduces Weight Gain with Transient Glucose Improvements in Diet-Induced Obesity Diabetes. 69. DOI: 10.2337/Db20-1759-P  0.319
2017 Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism. 26: 185-197.e3. PMID 28683286 DOI: 10.1016/J.Cmet.2017.05.015  0.364
2017 Douglass JD, Dorfman MD, Fasnacht R, Shaffer LD, Thaler JP. Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Molecular Metabolism. 6: 366-373. PMID 28377875 DOI: 10.1016/J.Molmet.2017.01.010  0.36
2017 Dorfman MD, Krull JE, Douglass JD, Fasnacht R, Lara-Lince F, Meek TH, Shi X, Damian V, Nguyen HT, Matsen ME, Morton GJ, Thaler JP. Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature Communications. 8: 14556. PMID 28223698 DOI: 10.1038/Ncomms14556  0.329
2017 Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Deletion of Protein Kinase C Lambda in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. PMID 28073831 DOI: 10.2337/Db16-0482  0.413
2016 Douglass JD, Dorfman MD, Thaler JP. Glia: silent partners in energy homeostasis and obesity pathogenesis. Diabetologia. PMID 27986987 DOI: 10.1007/S00125-016-4181-3  0.384
2016 Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG, Schwartz MW, Morton GJ. Functional identification of a neurocircuit regulating blood glucose. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001850 DOI: 10.1073/Pnas.1521160113  0.407
2015 Dorfman MD, Thaler JP. Hypothalamic inflammation and gliosis in obesity. Current Opinion in Endocrinology, Diabetes, and Obesity. 22: 325-30. PMID 26192704 DOI: 10.1097/Med.0000000000000182  0.319
2014 Berkseth KE, Guyenet SJ, Melhorn SJ, Lee D, Thaler JP, Schur EA, Schwartz MW. Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology. 155: 2858-67. PMID 24914942 DOI: 10.1210/En.2014-1121  0.354
2014 Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, et al. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia. 62: 17-25. PMID 24166765 DOI: 10.1002/Glia.22580  0.339
2013 Karatsoreos IN, Thaler JP, Borgland SL, Champagne FA, Hurd YL, Hill MN. Food for thought: hormonal, experiential, and neural influences on feeding and obesity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17610-6. PMID 24198352 DOI: 10.1523/Jneurosci.3452-13.2013  0.314
2013 Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes. 62: 2629-34. PMID 23881189 DOI: 10.2337/Db12-1605  0.335
2013 Lee D, Thaler JP, Berkseth KE, Melhorn SJ, Schwartz MW, Schur EA. Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. American Journal of Physiology. Endocrinology and Metabolism. 304: E1245-50. PMID 23548614 DOI: 10.1152/Ajpendo.00020.2013  0.304
2013 Guyenet SJ, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP. High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Research. 1512: 97-105. PMID 23548599 DOI: 10.1016/J.Brainres.2013.03.033  0.349
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, et al. Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation. 122: 153-62. PMID 22201683 DOI: 10.1172/Jci59660  0.377
2011 German JP, Thaler JP, Wisse BE, Oh-I S, Sarruf DA, Matsen ME, Fischer JD, Taborsky GJ, Schwartz MW, Morton GJ. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology. 152: 394-404. PMID 21159853 DOI: 10.1210/En.2010-0890  0.31
2010 Thaler JP, Schwartz MW. Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology. 151: 4109-15. PMID 20573720 DOI: 10.1210/En.2010-0336  0.34
2010 German JP, Wisse BE, Thaler JP, Oh-I S, Sarruf DA, Ogimoto K, Kaiyala KJ, Fischer JD, Matsen ME, Taborsky GJ, Schwartz MW, Morton GJ. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 59: 1626-34. PMID 20424233 DOI: 10.2337/Db09-1918  0.318
2010 Oh-I S, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, Schwartz MW. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. American Journal of Physiology. Endocrinology and Metabolism. 299: E47-53. PMID 20371733 DOI: 10.1152/Ajpendo.00026.2010  0.34
2010 Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes. 59: 1817-24. PMID 20357365 DOI: 10.2337/Db09-1878  0.343
2010 Thaler JP, Choi SJ, Schwartz MW, Wisse BE. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Frontiers in Neuroendocrinology. 31: 79-84. PMID 19822168 DOI: 10.1016/J.Yfrne.2009.10.002  0.332
2010 Thaler JP, Schwartz MW. Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up Endocrine Reviews. 31: 600-600. DOI: 10.1210/Edrv.31.4.9998  0.339
2009 Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW. Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology. 150: 5362-72. PMID 19819945 DOI: 10.1210/En.2009-0509  0.328
2008 Thaler JP, Cummings DE. Metabolism: food alert. Nature. 452: 941-2. PMID 18432230 DOI: 10.1038/452941A  0.325
2008 Ghosh S, Marquardt T, Thaler JP, Carter N, Andrews SE, Pfaff SL, Hunter T. Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proceedings of the National Academy of Sciences of the United States of America. 105: 335-40. PMID 18162555 DOI: 10.1073/Pnas.0705713105  0.633
2007 Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circulation Research. 100: 1589-96. PMID 17478729 DOI: 10.1161/Circresaha.106.142851  0.352
2005 Mizutani A, Wang L, Rajan H, Vig PJ, Alaynick WA, Thaler JP, Tsai CC. Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. The Embo Journal. 24: 3339-51. PMID 16121196 DOI: 10.1038/Sj.Emboj.7600785  0.636
2004 Thaler JP, Koo SJ, Kania A, Lettieri K, Andrews S, Cox C, Jessell TM, Pfaff SL. A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 41: 337-50. PMID 14766174 DOI: 10.1016/S0896-6273(04)00011-X  0.672
2002 Thaler JP, Lee SK, Jurata LW, Gill GN, Pfaff SL. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell. 110: 237-49. PMID 12150931 DOI: 10.1016/S0092-8674(02)00823-1  0.684
1999 Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J, Pfaff SL. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron. 23: 675-87. PMID 10482235 DOI: 10.1016/S0896-6273(01)80027-1  0.666
1999 Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nature Genetics. 23: 71-5. PMID 10471502 DOI: 10.1038/12674  0.579
1993 Stewart RJ, Thaler JP, Goldstein LS. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein. Proceedings of the National Academy of Sciences of the United States of America. 90: 5209-13. PMID 8506368 DOI: 10.1073/Pnas.90.11.5209  0.336
Low-probability matches (unlikely to be authored by this person)
2022 Niraula A, Fasnacht RD, Ness KM, Frey JM, Cuschieri SA, Dorfman MD, Thaler JP. Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity. Diabetes. PMID 36318114 DOI: 10.2337/db21-1072  0.297
2013 Meek TH, Wisse BE, Thaler JP, Guyenet SJ, Matsen ME, Fischer JD, Taborsky GJ, Schwartz MW, Morton GJ. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes. 62: 1512-8. PMID 23274899 DOI: 10.2337/Db12-0837  0.296
2009 Thaler JP, Cummings DE. Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology. 150: 2518-25. PMID 19372197 DOI: 10.1210/Edrv.30.4.9999  0.291
2013 Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ. In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. American Journal of Physiology. Endocrinology and Metabolism. 304: E734-46. PMID 23384771 DOI: 10.1152/Ajpendo.00488.2012  0.281
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, et al. Obesity is associated with hypothalamic injury in rodents and humans (The Journal of Clinical Investigation (2012) 122, 1, (153-162) DOI: 10.1172/JCI59660) Journal of Clinical Investigation. 122: 778. DOI: 10.1172/Jci62813  0.258
2012 Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE. Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. Plos One. 7: e41473. PMID 22936977 DOI: 10.1371/Journal.Pone.0041473  0.248
2023 Douglass JD, Ness KM, Valdearcos M, Wyse-Jackson A, Dorfman MD, Frey JM, Fasnacht RD, Santiago OD, Niraula A, Banerjee J, Robblee M, Koliwad SK, Thaler JP. Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance. Cell Metabolism. PMID 37572666 DOI: 10.1016/j.cmet.2023.07.008  0.246
2020 Ness KM, Douglass J, Valdearcos-Contreras M, Dorfman MD, Niraula A, Koliwad SK, Thaler J. 1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis Diabetes. 69. DOI: 10.2337/Db20-1769-P  0.231
2023 Dorfman MD, Monfeuga T, Melhorn SJ, Kanter JE, Frey JM, Fasnacht RD, Chandran A, Lala E, Velasco I, Rubinow KB, Meek TH, Schur EA, Bornfeldt KE, Thaler JP. Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 37053049 DOI: 10.1152/ajpendo.00059.2023  0.189
2018 Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism. 27: 1356. PMID 29874568 DOI: 10.1016/j.cmet.2018.04.019  0.162
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