| Year |
Citation |
Score |
| 2020 |
Low LA, Mummery C, Berridge BR, Austin CP, Tagle DA. Organs-on-chips: into the next decade. Nature Reviews. Drug Discovery. PMID 32913334 DOI: 10.1038/s41573-020-0079-3 |
0.317 |
|
| 2019 |
Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. Nature Reviews. Drug Discovery. PMID 31836861 DOI: 10.1038/s41573-019-0049-9 |
0.334 |
|
| 2019 |
Huang R, Zhu H, Shinn P, Ngan D, Ye L, Thakur A, Grewal G, Zhao T, Southall N, Hall MD, Simeonov A, Austin CP. The NCATS Pharmaceutical Collection: a 10-year update. Drug Discovery Today. PMID 31585169 DOI: 10.1016/J.Drudis.2019.09.019 |
0.328 |
|
| 2019 |
Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Frontiers in Pharmacology. 10: 445. PMID 31133849 DOI: 10.3389/Fphar.2019.00445 |
0.312 |
|
| 2018 |
Nilubol N, Boufraqech M, Zhang L, Gaskins K, Shen M, Zhang YQ, Gara SK, Austin CP, Kebebew E. Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response. Oncotarget. 9: 33030-33042. PMID 30250647 DOI: 10.18632/oncotarget.26050 |
0.344 |
|
| 2018 |
Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, ... ... Austin CP, et al. The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. PMID 29877628 DOI: 10.1111/Cts.12570 |
0.341 |
|
| 2018 |
Marshall LJ, Austin CP, Casey W, Fitzpatrick SC, Willett C. Recommendations toward a human pathway-based approach to disease research. Drug Discovery Today. PMID 29870792 DOI: 10.1016/j.drudis.2018.05.038 |
0.323 |
|
| 2018 |
Huang R, Xia M, Sakamuru S, Zhao J, Lynch C, Zhao T, Zhu H, Austin CP, Simeonov A. Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles. Scientific Reports. 8: 3783. PMID 29491351 DOI: 10.1038/s41598-018-22046-w |
0.36 |
|
| 2017 |
Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development. Clinical and Translational Science. PMID 29271559 DOI: 10.1111/cts.12531 |
0.315 |
|
| 2017 |
Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 0. PMID 28613987 DOI: 10.1080/15548627.2017.1329081 |
0.301 |
|
| 2017 |
Hsu CW, Huang R, Ramos MSA, Austin CP, Simeonov A, Xia M. Advances in high-throughput screening technology for toxicology International Journal of Risk Assessment and Management. 20: 109. DOI: 10.1504/IJRAM.2017.082562 |
0.353 |
|
| 2016 |
Huang R, Xia M, Sakamuru S, Zhao J, Shahane SA, Attene-Ramos M, Zhao T, Austin CP, Simeonov A. Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization. Nature Communications. 7: 10425. PMID 26811972 DOI: 10.1038/ncomms10425 |
0.333 |
|
| 2016 |
Brooks PJ, Yang NN, Austin CP. Gene Therapy: The View from NCATS. Human Gene Therapy. 27: 7-13. PMID 26784641 DOI: 10.1089/hum.2016.29018.pjb |
0.341 |
|
| 2015 |
Colvis CM, Austin CP. The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing. Assay and Drug Development Technologies. 13: 297-8. PMID 26241208 DOI: 10.1089/adt.2015.29006.cmcdrrr |
0.323 |
|
| 2015 |
Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, ... ... Austin CP, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796 |
0.37 |
|
| 2015 |
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023 |
0.308 |
|
| 2015 |
Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, et al. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives. 123: 458-66. PMID 25622337 DOI: 10.1289/Ehp.1408775 |
0.322 |
|
| 2014 |
Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED. Identification of small molecule modulators of gene transcription with anticancer activity. Acs Chemical Biology. 9: 2603-11. PMID 25188650 DOI: 10.1021/Cb500532X |
0.387 |
|
| 2014 |
Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, ... ... Austin CP, et al. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports. 4: 5664. PMID 25012808 DOI: 10.1038/Srep05664 |
0.354 |
|
| 2014 |
Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, Coksaygan T, DeTolla L, Marugan JJ, Austin CP, McKew JC, Gong DW, Zheng W. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. Journal of Biomolecular Screening. 19: 1164-1173. PMID 24907126 DOI: 10.1177/1087057114537378 |
0.337 |
|
| 2014 |
Blackford JA, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS. Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology (Baltimore, Md.). 28: 1194-206. PMID 24850414 DOI: 10.1210/Me.2014-1069 |
0.377 |
|
| 2014 |
Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/Journal.Pone.0090766 |
0.355 |
|
| 2014 |
Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Research. 74: 2520-32. PMID 24599128 DOI: 10.1158/0008-5472.Can-13-2033 |
0.336 |
|
| 2014 |
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, ... ... Austin CP, et al. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54. PMID 24469833 DOI: 10.1073/Pnas.1311846111 |
0.389 |
|
| 2014 |
Colvis CM, Austin CP. Innovation in therapeutics development at the NCATS. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 230-2. PMID 24317308 DOI: 10.1038/npp.2013.247 |
0.338 |
|
| 2014 |
Ottinger EA, Kao ML, Carrillo-Carrasco N, Yanjanin N, Shankar RK, Janssen M, Brewster M, Scott I, Xu X, Cradock J, Terse P, Dehdashti SJ, Marugan J, Zheng W, Portilla L, ... ... Austin CP, et al. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Current Topics in Medicinal Chemistry. 14: 330-9. PMID 24283970 DOI: 10.2174/1568026613666131127160118 |
0.312 |
|
| 2014 |
Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, ... Austin CP, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/Hmg/Ddt542 |
0.375 |
|
| 2014 |
Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. Journal of Biomolecular Screening. 19: 66-76. PMID 24003057 DOI: 10.1177/1087057113502851 |
0.382 |
|
| 2013 |
Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, et al. A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. Plos One. 8: e79950. PMID 24223206 DOI: 10.1371/Journal.Pone.0079950 |
0.331 |
|
| 2013 |
Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. Plos One. 8: e75252. PMID 24073257 DOI: 10.1371/journal.pone.0075252 |
0.403 |
|
| 2013 |
Xia M, Huang R, Sakamuru S, Alcorta D, Cho MH, Lee DH, Park DM, Kelley MJ, Sommer J, Austin CP. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy. 14: 638-47. PMID 23792643 DOI: 10.4161/cbt.24596 |
0.341 |
|
| 2013 |
Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrobial Agents and Chemotherapy. 57: 425-35. PMID 23129054 DOI: 10.1128/Aac.00920-12 |
0.319 |
|
| 2013 |
Mathews LA, Guha R, Shinn P, Young RM, Lim K, Keller J, Liu D, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang J, Michael S, Mott BT, Patel PR, ... ... Austin CP, et al. Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas. Cancer Research. 73: 4543-4543. DOI: 10.1158/1538-7445.Am2013-4543 |
0.398 |
|
| 2012 |
Sun H, Veith H, Xia M, Austin CP, Tice RR, Huang R. Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Molecular Informatics. 31: 783-792. PMID 23459712 DOI: 10.1002/minf.201200065 |
0.342 |
|
| 2012 |
Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Journal of Translational Medicine. 10: 198. PMID 22999104 DOI: 10.1186/1479-5876-10-198 |
0.377 |
|
| 2012 |
Swaroop M, Thorne N, Rao MS, Austin CP, McKew JC, Zheng W. Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes. Journal of Biomolecular Screening. 17: 1243-51. PMID 22923786 DOI: 10.1177/1087057112456877 |
0.317 |
|
| 2012 |
Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/Pnas.1200037109 |
0.351 |
|
| 2012 |
Sun H, Xia M, Austin CP, Huang R. Paradigm shift in toxicity testing and modeling. The Aaps Journal. 14: 473-80. PMID 22528508 DOI: 10.1208/s12248-012-9358-1 |
0.349 |
|
| 2012 |
Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin CP, Xia M. Application of a homogenous membrane potential assay to assess mitochondrial function. Physiological Genomics. 44: 495-503. PMID 22433785 DOI: 10.1152/physiolgenomics.00161.2011 |
0.318 |
|
| 2012 |
Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/Journal.Pone.0029861 |
0.376 |
|
| 2012 |
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/Toxsci/Kfs023 |
0.37 |
|
| 2012 |
Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Research. 72: 1055-8. PMID 22246671 DOI: 10.1158/0008-5472.CAN-11-3439 |
0.323 |
|
| 2011 |
Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5239-43. PMID 21831635 DOI: 10.1016/j.bmcl.2011.07.043 |
0.315 |
|
| 2011 |
Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/Jm200497T |
0.312 |
|
| 2011 |
Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (New York, N.Y.). 333: 724-9. PMID 21817045 DOI: 10.1126/Science.1205216 |
0.358 |
|
| 2011 |
Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cellular and Molecular Neurobiology. 31: 901-7. PMID 21598037 DOI: 10.1007/s10571-011-9689-y |
0.359 |
|
| 2011 |
Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199 |
0.351 |
|
| 2011 |
Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/Aac.00618-10 |
0.367 |
|
| 2010 |
Shukla SJ, Huang R, Austin CP, Xia M. The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discovery Today. 15: 997-1007. PMID 20708096 DOI: 10.1016/j.drudis.2010.07.007 |
0.353 |
|
| 2010 |
Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015 |
0.309 |
|
| 2010 |
Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical Pharmacology. 79: 1272-80. PMID 20067776 DOI: 10.1016/j.bcp.2009.12.021 |
0.33 |
|
| 2010 |
Shen M, Zhang Y, Wiestner AU, Ashlock MA, Austin CP, Auld DS. Abstract 3685: A strategy to identify therapeutic candidates for chronic lymphocytic leukemia from a library of FDA approved drugs Cancer Research. 70: 3685-3685. DOI: 10.1158/1538-7445.Am10-3685 |
0.403 |
|
| 2009 |
Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin CP, Inglese J. Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Molecular Cancer. 8: 117. PMID 20003191 DOI: 10.1186/1476-4598-8-117 |
0.348 |
|
| 2009 |
Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/Nbt.1581 |
0.347 |
|
| 2009 |
Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/Toxsci/Kfp231 |
0.32 |
|
| 2009 |
Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. A high-throughput approach for identification of novel general anesthetics. Plos One. 4: e7150. PMID 19777064 DOI: 10.1371/Journal.Pone.0007150 |
0.344 |
|
| 2009 |
Norton JT, Titus SA, Dexter D, Austin CP, Zheng W, Huang S. Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening. 14: 1045-53. PMID 19762548 DOI: 10.1177/1087057109343120 |
0.378 |
|
| 2009 |
Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 5: 765-71. PMID 19734910 DOI: 10.1038/Nchembio.215 |
0.315 |
|
| 2009 |
Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/B902021G |
0.358 |
|
| 2009 |
Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/J.Ab.2009.07.003 |
0.346 |
|
| 2009 |
Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/J.Bmc.2009.05.054 |
0.371 |
|
| 2009 |
Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123 |
0.333 |
|
| 2009 |
Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. Plos One. 4: e5740. PMID 19484131 DOI: 10.1371/journal.pone.0005740 |
0.375 |
|
| 2009 |
Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3686-92. PMID 19464886 DOI: 10.1016/J.Bmcl.2009.01.057 |
0.301 |
|
| 2009 |
Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114 |
0.357 |
|
| 2008 |
Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977 |
0.364 |
|
| 2008 |
Kimple AJ, Yasgar A, Hughes M, Jadhav A, Willard FS, Muller RE, Austin CP, Inglese J, Ibeanu GC, Siderovski DP, Simeonov A. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Combinatorial Chemistry & High Throughput Screening. 11: 396-409. PMID 18537560 DOI: 10.2174/138620708784534770 |
0.333 |
|
| 2008 |
Cho MH, Niles A, Huang R, Inglese J, Austin CP, Riss T, Xia M. A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicology in Vitro : An International Journal Published in Association With Bibra. 22: 1099-106. PMID 18400464 DOI: 10.1016/j.tiv.2008.02.013 |
0.352 |
|
| 2008 |
Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nature Medicine. 14: 407-12. PMID 18345010 DOI: 10.1038/Nm1737 |
0.317 |
|
| 2008 |
Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. Plos Neglected Tropical Diseases. 2: e127. PMID 18235848 DOI: 10.1371/Journal.Pntd.0000127 |
0.387 |
|
| 2008 |
Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786 |
0.351 |
|
| 2008 |
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry. 375: 237-48. PMID 18211814 DOI: 10.1016/J.Ab.2007.12.028 |
0.378 |
|
| 2008 |
Simeonov A, Yasgar A, Jadhav A, Lokesh GL, Klumpp C, Michael S, Austin CP, Natarajan A, Inglese J. Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Analytical Biochemistry. 375: 60-70. PMID 18158907 DOI: 10.1016/J.Ab.2007.11.039 |
0.358 |
|
| 2008 |
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, ... ... Austin CP, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/J.Bmcl.2007.10.100 |
0.359 |
|
| 2007 |
Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/Adt.2006.048 |
0.366 |
|
| 2004 |
Austin CP, Brady LS, Insel TR, Collins FS. NIH Molecular Libraries Initiative. Science (New York, N.Y.). 306: 1138-9. PMID 15542455 DOI: 10.1126/Science.1105511 |
0.369 |
|
| 2003 |
Austin CP. The completed human genome: implications for chemical biology. Current Opinion in Chemical Biology. 7: 511-5. PMID 12941427 DOI: 10.1016/S1367-5931(03)00083-8 |
0.301 |
|
| 2000 |
Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis with retroviral vectors. Methods in Enzymology. 327: 118-45. PMID 11044979 DOI: 10.1016/S0076-6879(00)27272-8 |
0.589 |
|
| 1998 |
Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis using retroviral vectors. Methods (San Diego, Calif.). 14: 393-406. PMID 9608510 DOI: 10.1006/Meth.1998.0594 |
0.592 |
|
| 1996 |
Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 93: 589-95. PMID 8570600 DOI: 10.1073/Pnas.93.2.589 |
0.686 |
|
| 1995 |
Austin CP, Feldman DE, Ida JA, Cepko CL. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development (Cambridge, England). 121: 3637-50. PMID 8582277 |
0.492 |
|
| 1994 |
Austin CP, Cepko CL. Retrovirus mediated gene transduction into the vertebrate CNS. Gene Therapy. 1: S6-9. PMID 8542405 |
0.415 |
|
| 1993 |
Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 225: 933-60. PMID 8231895 DOI: 10.1016/0076-6879(93)25059-B |
0.556 |
|
| 1991 |
Misson JP, Austin CP, Takahashi T, Cepko CL, Caviness VS. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex (New York, N.Y. : 1991). 1: 221-9. PMID 1668365 |
0.439 |
|
| 1990 |
Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S. Studies of cortical development using retrovirus vectors. Cold Spring Harbor Symposia On Quantitative Biology. 55: 265-78. PMID 2132820 DOI: 10.1101/Sqb.1990.055.01.029 |
0.529 |
|
| 1990 |
Austin CP, Cepko CL. Cellular migration patterns in the developing mouse cerebral cortex. Development (Cambridge, England). 110: 713-32. PMID 2088716 |
0.443 |
|
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