Christopher P. Austin - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
development of a toolbox of reagents and technologies to translate genome sequence into functional insights
Website:
http://www.genome.gov/12512321

170 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR, Kavlock RJ, Kitano H, Lidbury BA, Muotri AR, Peng SQ, Sakharov D, Seidle T, et al. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environmental Health Perspectives. 123: A268-72. PMID 26523530 DOI: 10.1289/ehp.1510345  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/nchembio.1867  1
2015 Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, Pattaradilokrat S, Martin S, Qi Y, Nair SC, Bolland S, Cohen JI, Austin CP, Long CA, Myers TG, et al. Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. Cell Reports. PMID 26190101 DOI: 10.1016/j.celrep.2015.06.058  1
2015 Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, ... ... Austin CP, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/journal.pone.0130796  1
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  1
2015 Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environmental Health Perspectives. 123: 49-56. PMID 25302578 DOI: 10.1289/ehp.1408642  1
2015 Colvis CM, Austin CP. The NIH-industry new therapeutic uses pilot program: Demonstrating the power of crowdsourcing Assay and Drug Development Technologies. 13: 297-298. DOI: 10.1089/adt.2015.29006.cmcdrrr  1
2014 Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED. Identification of small molecule modulators of gene transcription with anticancer activity. Acs Chemical Biology. 9: 2603-11. PMID 25188650 DOI: 10.1021/cb500532x  1
2014 Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, ... ... Austin CP, et al. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports. 4: 5664. PMID 25012808 DOI: 10.1038/srep05664  1
2014 Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, Coksaygan T, DeTolla L, Marugan JJ, Austin CP, McKew JC, Gong DW, Zheng W. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. Journal of Biomolecular Screening. 19: 1164-1173. PMID 24907126 DOI: 10.1177/1087057114537378  1
2014 Blackford JA, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS. Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology (Baltimore, Md.). 28: 1194-206. PMID 24850414 DOI: 10.1210/me.2014-1069  1
2014 Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/nar/gku275  1
2014 Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/journal.pone.0090766  1
2014 Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Research. 74: 2520-32. PMID 24599128 DOI: 10.1158/0008-5472.CAN-13-2033  1
2014 Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, ... ... Austin CP, et al. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54. PMID 24469833 DOI: 10.1073/pnas.1311846111  1
2014 Colvis CM, Austin CP. Innovation in therapeutics development at the NCATS. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 230-2. PMID 24317308 DOI: 10.1038/npp.2013.247  1
2014 Ottinger EA, Kao ML, Carrillo-Carrasco N, Yanjanin N, Shankar RK, Janssen M, Brewster M, Scott I, Xu X, Cradock J, Terse P, Dehdashti SJ, Marugan J, Zheng W, Portilla L, ... ... Austin CP, et al. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Current Topics in Medicinal Chemistry. 14: 330-9. PMID 24283970 DOI: 10.2174/1568026613666131127160118  1
2014 Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, ... Austin CP, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/hmg/ddt542  1
2014 Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. Journal of Biomolecular Screening. 19: 66-76. PMID 24003057 DOI: 10.1177/1087057113502851  1
2013 Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, et al. A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. Plos One. 8: e79950. PMID 24223206 DOI: 10.1371/journal.pone.0079950  1
2013 Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/jm400904m  1
2013 Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. Plos One. 8: e75252. PMID 24073257 DOI: 10.1371/journal.pone.0075252  1
2013 Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. Acs Medicinal Chemistry Letters. 4: 79-84. PMID 24040486 DOI: 10.1021/ml300286h  1
2013 Dehdashti SJ, Zheng W, Gever JR, Wilhelm R, Nguyen DT, Sittampalam G, McKew JC, Austin CP, Prusiner SB. A high-throughput screening assay for determining cellular levels of total tau protein. Current Alzheimer Research. 10: 679-87. PMID 23905996 DOI: 10.2174/15672050113109990143  1
2013 Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, Schnellmann RG, Beeson CC, Tice RR, Austin CP, Xia M. Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. Chemical Research in Toxicology. 26: 1323-32. PMID 23895456 DOI: 10.1021/tx4001754  1
2013 Sun H, Xia M, Shahane SA, Jadhav A, Austin CP, Huang R. Are hERG channel blockers also phospholipidosis inducers? Bioorganic & Medicinal Chemistry Letters. 23: 4587-90. PMID 23856051 DOI: 10.1016/j.bmcl.2013.06.034  1
2013 Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/ncomms3044  1
2013 Xia M, Huang R, Sakamuru S, Alcorta D, Cho MH, Lee DH, Park DM, Kelley MJ, Sommer J, Austin CP. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy. 14: 638-47. PMID 23792643 DOI: 10.4161/cbt.24596  1
2013 Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/JNEUROSCI.4742-12.2013  1
2013 Attene-Ramos MS, Miller N, Huang R, Michael S, Itkin M, Kavlock RJ, Austin CP, Shinn P, Simeonov A, Tice RR, Xia M. The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discovery Today. 18: 716-23. PMID 23732176 DOI: 10.1016/j.drudis.2013.05.015  1
2013 Tice RR, Austin CP, Kavlock RJ, Bucher JR. Improving the human hazard characterization of chemicals: a Tox21 update. Environmental Health Perspectives. 121: 756-65. PMID 23603828 DOI: 10.1289/ehp.1205784  1
2013 Teng C, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions. 203: 556-64. PMID 23562765 DOI: 10.1016/j.cbi.2013.03.013  1
2013 Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR, et al. Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. Altex. 30: 51-6. PMID 23338806  1
2013 Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrobial Agents and Chemotherapy. 57: 425-35. PMID 23129054 DOI: 10.1128/AAC.00920-12  1
2013 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders (Journal of Biological Chemistry (2012) 287, (39349-39360)) Journal of Biological Chemistry. 288: 296. DOI: 10.1074/jbc.A112.357707  1
2012 Sun H, Veith H, Xia M, Austin CP, Tice RR, Huang R. Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Molecular Informatics. 31: 783-792. PMID 23459712 DOI: 10.1002/minf.201200065  1
2012 Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490: 187-91. PMID 23060188 DOI: 10.1038/nature11556  1
2012 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Finkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. The Journal of Biological Chemistry. 287: 39349-60. PMID 23035117 DOI: 10.1074/jbc.M112.357707  1
2012 Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Journal of Translational Medicine. 10: 198. PMID 22999104 DOI: 10.1186/1479-5876-10-198  1
2012 Swaroop M, Thorne N, Rao MS, Austin CP, McKew JC, Zheng W. Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes. Journal of Biomolecular Screening. 17: 1243-51. PMID 22923786 DOI: 10.1177/1087057112456877  1
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Austin CP, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/nchembio.1060  1
2012 Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/pnas.1200037109  1
2012 Sun H, Shahane S, Xia M, Austin CP, Huang R. Structure based model for the prediction of phospholipidosis induction potential of small molecules. Journal of Chemical Information and Modeling. 52: 1798-805. PMID 22725677 DOI: 10.1021/ci3001875  1
2012 Shukla SJ, Huang R, Simmons SO, Tice RR, Witt KL, Vanleer D, Ramabhadran R, Austin CP, Xia M. Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environmental Health Perspectives. 120: 1150-6. PMID 22551509 DOI: 10.1289/ehp.1104709  1
2012 Sun H, Xia M, Austin CP, Huang R. Paradigm shift in toxicity testing and modeling. The Aaps Journal. 14: 473-80. PMID 22528508 DOI: 10.1208/s12248-012-9358-1  1
2012 Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin CP, Xia M. Application of a homogenous membrane potential assay to assess mitochondrial function. Physiological Genomics. 44: 495-503. PMID 22433785 DOI: 10.1152/physiolgenomics.00161.2011  1
2012 Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proceedings of the National Academy of Sciences of the United States of America. 109: 5423-8. PMID 22431602 DOI: 10.1073/pnas.1114278109  1
2012 Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/ml200244k  1
2012 Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/journal.pone.0029861  1
2012 Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/toxsci/kfs023  1
2012 Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Research. 72: 1055-8. PMID 22246671 DOI: 10.1158/0008-5472.CAN-11-3439  1
2012 Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. Reply to Kojo: Mechanisms of antioxidant-induced DNA damage Proceedings of the National Academy of Sciences of the United States of America. 109: E2029. DOI: 10.1073/pnas.1207795109  1
2011 Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W. The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm. 2: 1016-1020. PMID 22408719 DOI: 10.1039/C1MD00145K  1
2011 Sun H, Veith H, Xia M, Austin CP, Huang R. Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. Journal of Chemical Information and Modeling. 51: 2474-81. PMID 21905670 DOI: 10.1021/ci200311w  1
2011 Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5239-43. PMID 21831635 DOI: 10.1016/j.bmcl.2011.07.043  1
2011 Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/jm200497t  1
2011 Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (New York, N.Y.). 333: 724-9. PMID 21817045 DOI: 10.1126/science.1205216  1
2011 Leister KP, Huang R, Goodwin BL, Chen A, Austin CP, Xia M. Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells. Current Chemical Genomics. 5: 21-9. PMID 21643507 DOI: 10.2174/1875397301105010021  1
2011 Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cellular and Molecular Neurobiology. 31: 901-7. PMID 21598037 DOI: 10.1007/s10571-011-9689-y  1
2011 Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environmental Health Perspectives. 119: 1142-8. PMID 21543282 DOI: 10.1289/ehp.1002952  1
2011 Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environmental and Molecular Mutagenesis. 52: 547-61. PMID 21538559 DOI: 10.1002/em.20656  1
2011 Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine. 3: 80ps16. PMID 21525397 DOI: 10.1126/scitranslmed.3001862  1
2011 Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199  1
2011 Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicology and Applied Pharmacology. 252: 250-8. PMID 21362439 DOI: 10.1016/j.taap.2011.02.016  1
2011 Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. The Journal of Biological Chemistry. 286: 11895-908. PMID 21321127 DOI: 10.1074/jbc.M110.200436  1
2011 Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. Pharmacology, Biochemistry, and Behavior. 98: 349-55. PMID 21296104 DOI: 10.1016/j.pbb.2011.02.001  1
2011 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. Journal of Medicinal Chemistry. 54: 1033-58. PMID 21250698 DOI: 10.1021/jm1008902  1
2011 Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/AAC.00618-10  1
2011 Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M. Identification of clinically used drugs that activate pregnane X receptors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 151-9. PMID 20966043 DOI: 10.1124/dmd.110.035105  1
2011 Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, VanLeer D, Auld DS, Austin CP, Xia M. Identification of clinically utilized drugs that activate pregnane X receptors (Drug Metabolism and Disposition (2011) 39 (151-159)) Drug Metabolism and Disposition. 39: 351. DOI: 10.1124/dmd.39.2.351  1
2010 McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. Acs Chemical Neuroscience. 1: 559-574. PMID 21116448 DOI: 10.1021/cn100040h  1
2010 Shukla SJ, Huang R, Austin CP, Xia M. The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discovery Today. 15: 997-1007. PMID 20708096 DOI: 10.1016/j.drudis.2010.07.007  1
2010 Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ. Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environmental Science & Technology. 44: 5979-85. PMID 20602530 DOI: 10.1021/es102150z  1
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/j.bmcl.2010.04.015  1
2010 Terry S, Austin C, Inglese J, Meeker D, Terry P. Assay, preclinical, and clinical brick walls and opportunities for system change through GRANDRx Assay and Drug Development Technologies. 8: 128-134. PMID 20307201 DOI: 10.1089/adt.2010.0802.rt  1
2010 Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay and Drug Development Technologies. 8: 367-79. PMID 20230302 DOI: 10.1089/adt.2009.0245  1
2010 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Sidransky E, Aungst RA, Liu K, Sadhukhan SK, Austin CP. Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. European Journal of Medicinal Chemistry. 45: 1880-97. PMID 20206419 DOI: 10.1016/j.ejmech.2010.01.027  1
2010 Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical Pharmacology. 79: 1272-80. PMID 20067776 DOI: 10.1016/j.bcp.2009.12.021  1
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/jm901577g  1
2010 Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/jm901069a  1
2010 Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. Journal of Medicinal Chemistry. 53: 37-51. PMID 19908840 DOI: 10.1021/jm901070c  1
2010 Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Research. 38: e11. PMID 19897549 DOI: 10.1093/nar/gkp899  1
2009 Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin CP, Inglese J. Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Molecular Cancer. 8: 117. PMID 20003191 DOI: 10.1186/1476-4598-8-117  1
2009 Xia M, Guo V, Huang R, Inglese J, Nirenberg M, Austin CP. A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway. Current Chemical Genomics. 3: 7-12. PMID 19936037 DOI: 10.2174/1875397300903010007  1
2009 Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/nbt.1581  1
2009 Patnaik S, Dietz HC, Zheng W, Austin C, Marugan JJ. Multi-gram scale synthesis of FR180204. The Journal of Organic Chemistry. 74: 8870-3. PMID 19852504 DOI: 10.1021/jo901835m  1
2009 Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ. Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorganic & Medicinal Chemistry Letters. 19: 6700-5. PMID 19837585 DOI: 10.1016/j.bmcl.2009.09.121  1
2009 Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening. 14: 1216-27. PMID 19828774 DOI: 10.1177/1087057109349355  1
2009 Thomas CJ, Auld DS, Huang R, Huang W, Jadhav A, Johnson RL, Leister W, Maloney DJ, Marugan JJ, Michael S, Simeonov A, Southall N, Xia M, Zheng W, Inglese J, ... Austin CP, et al. The pilot phase of the NIH Chemical Genomics Center. Current Topics in Medicinal Chemistry. 9: 1181-93. PMID 19807664 DOI: 10.2174/156802609789753644  1
2009 Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/toxsci/kfp231  1
2009 Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. A high-throughput approach for identification of novel general anesthetics. Plos One. 4: e7150. PMID 19777064 DOI: 10.1371/journal.pone.0007150  1
2009 Norton JT, Titus SA, Dexter D, Austin CP, Zheng W, Huang S. Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening. 14: 1045-53. PMID 19762548 DOI: 10.1177/1087057109343120  1
2009 Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, et al. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. Journal of Medicinal Chemistry. 52: 6474-83. PMID 19761212 DOI: 10.1021/jm901021k  1
2009 Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 5: 765-71. PMID 19734910 DOI: 10.1038/nchembio.215  1
2009 Dorjsuren D, Wilson DM, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Research. 37: e128. PMID 19684079 DOI: 10.1093/nar/gkp641  1
2009 Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.CAN-09-0891  1
2009 Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/b902021g  1
2009 Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/pnas.0904506106  1
2009 Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/j.ab.2009.07.003  1
2009 Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/bi9006435  1
2009 Brimacombe KR, Hall MD, Auld DS, Inglese J, Austin CP, Gottesman MM, Fung KL. A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay and Drug Development Technologies. 7: 233-49. PMID 19548831 DOI: 10.1089/adt.2008.165  1
2009 Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/j.bmc.2009.05.054  1
2009 Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. Analytical and Bioanalytical Chemistry. 394: 1903-9. PMID 19521690 DOI: 10.1007/s00216-009-2879-5  1
2009 Shukla SJ, Nguyen DT, Macarthur R, Simeonov A, Frazee WJ, Hallis TM, Marks BD, Singh U, Eliason HC, Printen J, Austin CP, Inglese J, Auld DS. Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay and Drug Development Technologies. 7: 143-69. PMID 19505231 DOI: 10.1089/adt.2009.193  1
2009 Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/toxsci/kfp123  1
2009 Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. Plos One. 4: e5740. PMID 19484131 DOI: 10.1371/journal.pone.0005740  1
2009 MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. Monitoring compound integrity with cytochrome P450 assays and qHTS. Journal of Biomolecular Screening. 14: 538-46. PMID 19483146 DOI: 10.1177/1087057109336954  1
2009 Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3686-92. PMID 19464886 DOI: 10.1016/j.bmcl.2009.01.057  1
2009 Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. A new resorufin-based alpha-glucosidase assay for high-throughput screening. Analytical Biochemistry. 390: 79-84. PMID 19371716 DOI: 10.1016/j.ab.2009.04.010  1
2009 Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry. 52: 1450-8. PMID 19215089 DOI: 10.1021/jm8014525  1
2009 Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114  1
2009 Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proceedings of the National Academy of Sciences of the United States of America. 106: 2412-7. PMID 19196967 DOI: 10.1073/pnas.0813020106  1
2009 Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Molecular Cancer Therapeutics. 8: 240-8. PMID 19139134 DOI: 10.1158/1535-7163.MCT-08-0878  1
2009 Kajiyama H, Titus S, Austin CP, Chiotos K, Matsumoto T, Sakairi T, Kopp JB. Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. American Journal of Nephrology. 29: 153-63. PMID 18753740 DOI: 10.1159/000151770  1
2008 Urban DJ, Zheng W, Goker-Alpan O, Jadhav A, Lamarca ME, Inglese J, Sidransky E, Austin CP. Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. Combinatorial Chemistry & High Throughput Screening. 11: 817-24. PMID 19075603 DOI: 10.2174/138620708786734244  1
2008 Michael S, Auld D, Klumpp C, Jadhav A, Zheng W, Thorne N, Austin CP, Inglese J, Simeonov A. A robotic platform for quantitative high-throughput screening. Assay and Drug Development Technologies. 6: 637-57. PMID 19035846 DOI: 10.1089/adt.2008.150  1
2008 Zhu PJ, Zheng W, Auld DS, Jadhav A, Macarthur R, Olson KR, Peng K, Dotimas H, Austin CP, Inglese J. A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS. Combinatorial Chemistry & High Throughput Screening. 11: 545-59. PMID 18694391 DOI: 10.2174/138620708785204045  1
2008 Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay and Drug Development Technologies. 6: 551-5. PMID 18665782 DOI: 10.1089/adt.2008.149  1
2008 Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977  1
2008 Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Characterization of chemical libraries for luciferase inhibitory activity. Journal of Medicinal Chemistry. 51: 2372-86. PMID 18363348 DOI: 10.1021/jm701302v  1
2008 Simeonov A, Jadhav A, Thomas CJ, Wang Y, Huang R, Southall NT, Shinn P, Smith J, Austin CP, Auld DS, Inglese J. Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry. 51: 2363-71. PMID 18363325 DOI: 10.1021/jm701301m  1
2008 Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspectives. 116: 284-91. PMID 18335092 DOI: 10.1289/ehp.10727  1
2008 Babaoglu K, Simeonov A, Irwin JJ, Nelson ME, Feng B, Thomas CJ, Cancian L, Costi MP, Maltby DA, Jadhav A, Inglese J, Austin CP, Shoichet BK. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. Journal of Medicinal Chemistry. 51: 2502-11. PMID 18333608 DOI: 10.1021/jm701500e  1
2008 Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chemical Research in Toxicology. 21: 659-67. PMID 18281954 DOI: 10.1021/tx700365e  1
2008 Skoumbourdis AP, Huang R, Southall N, Leister W, Guo V, Cho MH, Inglese J, Nirenberg M, Austin CP, Xia M, Thomas CJ. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters. 18: 1297-303. PMID 18243697 DOI: 10.1016/j.bmcl.2008.01.028  1
2008 Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786  1
2008 Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry. 375: 237-48. PMID 18211814 DOI: 10.1016/j.ab.2007.12.028  1
2008 Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, ... ... Austin CP, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/j.bmcl.2007.10.100  1
2007 Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ. N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorganic & Medicinal Chemistry Letters. 17: 5783-9. PMID 17827006 DOI: 10.1016/j.bmcl.2007.08.050  1
2007 Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 13192-7. PMID 17670938 DOI: 10.1073/pnas.0705637104  1
2007 Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, Auld DS. High-throughput screening assays for the identification of chemical probes. Nature Chemical Biology. 3: 466-79. PMID 17637779 DOI: 10.1038/nchembio.2007.17  1
2007 Feng BY, Simeonov A, Jadhav A, Babaoglu K, Inglese J, Shoichet BK, Austin CP. A high-throughput screen for aggregation-based inhibition in a large compound library. Journal of Medicinal Chemistry. 50: 2385-90. PMID 17447748 DOI: 10.1021/jm061317y  1
2007 Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/adt.2006.048  1
2006 Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods in Enzymology. 414: 566-89. PMID 17110211 DOI: 10.1016/S0076-6879(06)14029-X  1
2006 Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proceedings of the National Academy of Sciences of the United States of America. 103: 11473-8. PMID 16864780 DOI: 10.1073/pnas.0604348103  1
2004 Austin CP, Brady LS, Insel TR, Collins FS. NIH Molecular Libraries Initiative. Science (New York, N.Y.). 306: 1138-9. PMID 15542455 DOI: 10.1126/science.1105511  1
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/ng0904-921  1
2004 Austin CP, Ky B, Ma L, Morris JA, Shughrue PJ. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 124: 3-10. PMID 14960334 DOI: 10.1016/j.neuroscience.2003.11.010  1
2003 Figueroa DJ, Borish L, Baramki D, Philip G, Austin CP, Evans JF. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 33: 1380-8. PMID 14519144 DOI: 10.1046/j.1365-2222.2003.01786.x  1
2003 Shughrue PJ, Ky B, Austin CP. Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. The Journal of Comparative Neurology. 465: 372-84. PMID 12966562 DOI: 10.1002/cne.10846  1
2003 Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. Neuroreport. 14: 951-4. PMID 12802181 DOI: 10.1097/01.wnr.0000074342.81633.63  1
2002 Ma L, Liu Y, Ky B, Shughrue PJ, Austin CP, Morris JA. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 80: 662-72. PMID 12504857 DOI: 10.1006/geno.2002.7012  1
2002 Blair IP, Adams LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35. Molecular Psychiatry. 7: 867-73. PMID 12232780 DOI: 10.1038/sj.mp.4001113  1
2002 Blair IP, Adam LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. Stylized transcript map of chromosome 4q35 encompassing the locus for a bipolar disorder susceptibility gene. Molecular Psychiatry. 7: 669. PMID 12192607 DOI: 10.1038/sj.mp.4001154  1
2002 Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, et al. A role for the melanocortin 4 receptor in sexual function. Proceedings of the National Academy of Sciences of the United States of America. 99: 11381-6. PMID 12172010 DOI: 10.1073/pnas.172378699  1
2002 Parent SA, Zhang T, Chrebet G, Clemas JA, Figueroa DJ, Ky B, Blevins RA, Austin CP, Rosen H. Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Gene. 293: 33-46. PMID 12137941 DOI: 10.1016/S0378-1119(02)00722-9  1
2002 Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, et al. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics. 79: 785-92. PMID 12036292 DOI: 10.1006/geno.2002.6771  1
2001 Hui Y, Yang G, Galczenski H, Figueroa DJ, Austin CP, Copeland NG, Gilbert DJ, Jenkins NA, Funk CD. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. The Journal of Biological Chemistry. 276: 47489-95. PMID 11591709 DOI: 10.1074/jbc.M107556200  1
2001 Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams DL, Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, ... ... Austin CP, et al. Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. The Journal of Biological Chemistry. 276: 36961-9. PMID 11481330 DOI: 10.1074/jbc.M105308200  1
2001 Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, Liu Q. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochemical and Biophysical Research Communications. 284: 1189-93. PMID 11414709 DOI: 10.1006/bbrc.2001.5098  1
2001 Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, ... ... Austin CP, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proceedings of the National Academy of Sciences of the United States of America. 98: 7564-9. PMID 11404457 DOI: 10.1073/pnas.121170598  1
2001 Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101  1
2001 Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, ... ... Austin CP, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genetics. 27: 89-93. PMID 11138005 DOI: 10.1038/83817  1
2000 Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, ... ... Austin CP, et al. Identification of receptors for neuromedin U and its role in feeding. Nature. 406: 70-4. PMID 10894543 DOI: 10.1038/35017610  1
2000 Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Austin CP, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/jbc.M003490200  1
2000 Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 97: 1230-5. PMID 10655513 DOI: 10.1073/pnas.97.3.1230  1
1999 Chen F, Figueroa DJ, Marmorstein AD, Zhang Q, Petrukhin K, Caskey CT, Austin CP. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 15149-54. PMID 10611353 DOI: 10.1073/pnas.96.26.15149  1
1999 Liu Q, Pong SS, Zeng Z, Zhang Q, Howard AD, Williams DL, Davidoff M, Wang R, Austin CP, McDonald TP, Bai C, George SR, Evans JF, Caskey CT. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. Biochemical and Biophysical Research Communications. 266: 174-8. PMID 10581185 DOI: 10.1006/bbrc.1999.1796  1
1999 Austin CP, Holder DJ, Ma L, Mixson LA, Caskey CT. Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia. Molecular Psychiatry. 4: 261-6. PMID 10395216  1
1999 Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658  1
1999 Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, et al. Receptor for motilin identified in the human gastrointestinal system. Science (New York, N.Y.). 284: 2184-8. PMID 10381885 DOI: 10.1126/science.284.5423.2184  1
1998 Petrukhin K, Koisti MJ, Bakall B, Li W, Xie G, Marknell T, Sandgren O, Forsman K, Holmgren G, Andreasson S, Vujic M, Bergen AA, McGarty-Dugan V, Figueroa D, Austin CP, et al. Identification of the gene responsible for Best macular dystrophy. Nature Genetics. 19: 241-7. PMID 9662395 DOI: 10.1038/915  1
1996 Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 93: 589-95. PMID 8570600 DOI: 10.1073/pnas.93.2.589  1
1995 Austin CP, Feldman DE, Ida JA, Cepko CL. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development (Cambridge, England). 121: 3637-50. PMID 8582277  1
1995 Cepko C, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 254: 387-419. PMID 8531701 DOI: 10.1016/0076-6879(95)54027-X  1
1994 Austin CP, Cepko CL. Retrovirus mediated gene transduction into the vertebrate CNS. Gene Therapy. 1: S6-9. PMID 8542405  1
1993 Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 225: 933-60. PMID 8231895 DOI: 10.1016/0076-6879(93)25059-B  1
1991 Misson JP, Austin CP, Takahashi T, Cepko CL, Caviness VS. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex (New York, N.Y. : 1991). 1: 221-9. PMID 1668365  1
1990 Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S. Studies of cortical development using retrovirus vectors. Cold Spring Harbor Symposia On Quantitative Biology. 55: 265-78. PMID 2132820  1
1990 Austin CP, Cepko CL. Cellular migration patterns in the developing mouse cerebral cortex. Development (Cambridge, England). 110: 713-32. PMID 2088716  1
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