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Christopher P. Austin - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
development of a toolbox of reagents and technologies to translate genome sequence into functional insights
Website:
http://www.genome.gov/12512321
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Year Citation  Score
2020 Low LA, Mummery C, Berridge BR, Austin CP, Tagle DA. Organs-on-chips: into the next decade. Nature Reviews. Drug Discovery. PMID 32913334 DOI: 10.1038/s41573-020-0079-3  0.317
2019 Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. Nature Reviews. Drug Discovery. PMID 31836861 DOI: 10.1038/s41573-019-0049-9  0.334
2019 Huang R, Zhu H, Shinn P, Ngan D, Ye L, Thakur A, Grewal G, Zhao T, Southall N, Hall MD, Simeonov A, Austin CP. The NCATS Pharmaceutical Collection: a 10-year update. Drug Discovery Today. PMID 31585169 DOI: 10.1016/J.Drudis.2019.09.019  0.328
2019 Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Frontiers in Pharmacology. 10: 445. PMID 31133849 DOI: 10.3389/Fphar.2019.00445  0.312
2018 Nilubol N, Boufraqech M, Zhang L, Gaskins K, Shen M, Zhang YQ, Gara SK, Austin CP, Kebebew E. Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response. Oncotarget. 9: 33030-33042. PMID 30250647 DOI: 10.18632/oncotarget.26050  0.344
2018 Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, ... ... Austin CP, et al. The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. PMID 29877628 DOI: 10.1111/Cts.12570  0.341
2018 Marshall LJ, Austin CP, Casey W, Fitzpatrick SC, Willett C. Recommendations toward a human pathway-based approach to disease research. Drug Discovery Today. PMID 29870792 DOI: 10.1016/j.drudis.2018.05.038  0.323
2018 Huang R, Xia M, Sakamuru S, Zhao J, Lynch C, Zhao T, Zhu H, Austin CP, Simeonov A. Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles. Scientific Reports. 8: 3783. PMID 29491351 DOI: 10.1038/s41598-018-22046-w  0.36
2017 Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development. Clinical and Translational Science. PMID 29271559 DOI: 10.1111/cts.12531  0.315
2017 Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 0. PMID 28613987 DOI: 10.1080/15548627.2017.1329081  0.301
2017 Hsu CW, Huang R, Ramos MSA, Austin CP, Simeonov A, Xia M. Advances in high-throughput screening technology for toxicology International Journal of Risk Assessment and Management. 20: 109. DOI: 10.1504/IJRAM.2017.082562  0.353
2016 Huang R, Xia M, Sakamuru S, Zhao J, Shahane SA, Attene-Ramos M, Zhao T, Austin CP, Simeonov A. Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization. Nature Communications. 7: 10425. PMID 26811972 DOI: 10.1038/ncomms10425  0.333
2016 Brooks PJ, Yang NN, Austin CP. Gene Therapy: The View from NCATS. Human Gene Therapy. 27: 7-13. PMID 26784641 DOI: 10.1089/hum.2016.29018.pjb  0.341
2015 Colvis CM, Austin CP. The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing. Assay and Drug Development Technologies. 13: 297-8. PMID 26241208 DOI: 10.1089/adt.2015.29006.cmcdrrr  0.323
2015 Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, ... ... Austin CP, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796  0.37
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023  0.308
2015 Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, et al. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives. 123: 458-66. PMID 25622337 DOI: 10.1289/Ehp.1408775  0.322
2014 Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED. Identification of small molecule modulators of gene transcription with anticancer activity. Acs Chemical Biology. 9: 2603-11. PMID 25188650 DOI: 10.1021/Cb500532X  0.387
2014 Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, ... ... Austin CP, et al. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports. 4: 5664. PMID 25012808 DOI: 10.1038/Srep05664  0.354
2014 Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, Coksaygan T, DeTolla L, Marugan JJ, Austin CP, McKew JC, Gong DW, Zheng W. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. Journal of Biomolecular Screening. 19: 1164-1173. PMID 24907126 DOI: 10.1177/1087057114537378  0.337
2014 Blackford JA, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS. Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology (Baltimore, Md.). 28: 1194-206. PMID 24850414 DOI: 10.1210/Me.2014-1069  0.377
2014 Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/Journal.Pone.0090766  0.355
2014 Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Research. 74: 2520-32. PMID 24599128 DOI: 10.1158/0008-5472.Can-13-2033  0.336
2014 Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, ... ... Austin CP, et al. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54. PMID 24469833 DOI: 10.1073/Pnas.1311846111  0.389
2014 Colvis CM, Austin CP. Innovation in therapeutics development at the NCATS. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 230-2. PMID 24317308 DOI: 10.1038/npp.2013.247  0.338
2014 Ottinger EA, Kao ML, Carrillo-Carrasco N, Yanjanin N, Shankar RK, Janssen M, Brewster M, Scott I, Xu X, Cradock J, Terse P, Dehdashti SJ, Marugan J, Zheng W, Portilla L, ... ... Austin CP, et al. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Current Topics in Medicinal Chemistry. 14: 330-9. PMID 24283970 DOI: 10.2174/1568026613666131127160118  0.312
2014 Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, ... Austin CP, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/Hmg/Ddt542  0.375
2014 Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. Journal of Biomolecular Screening. 19: 66-76. PMID 24003057 DOI: 10.1177/1087057113502851  0.382
2013 Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, et al. A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. Plos One. 8: e79950. PMID 24223206 DOI: 10.1371/Journal.Pone.0079950  0.331
2013 Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. Plos One. 8: e75252. PMID 24073257 DOI: 10.1371/journal.pone.0075252  0.403
2013 Xia M, Huang R, Sakamuru S, Alcorta D, Cho MH, Lee DH, Park DM, Kelley MJ, Sommer J, Austin CP. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy. 14: 638-47. PMID 23792643 DOI: 10.4161/cbt.24596  0.341
2013 Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrobial Agents and Chemotherapy. 57: 425-35. PMID 23129054 DOI: 10.1128/Aac.00920-12  0.319
2013 Mathews LA, Guha R, Shinn P, Young RM, Lim K, Keller J, Liu D, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang J, Michael S, Mott BT, Patel PR, ... ... Austin CP, et al. Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas. Cancer Research. 73: 4543-4543. DOI: 10.1158/1538-7445.Am2013-4543  0.398
2012 Sun H, Veith H, Xia M, Austin CP, Tice RR, Huang R. Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Molecular Informatics. 31: 783-792. PMID 23459712 DOI: 10.1002/minf.201200065  0.342
2012 Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Journal of Translational Medicine. 10: 198. PMID 22999104 DOI: 10.1186/1479-5876-10-198  0.377
2012 Swaroop M, Thorne N, Rao MS, Austin CP, McKew JC, Zheng W. Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes. Journal of Biomolecular Screening. 17: 1243-51. PMID 22923786 DOI: 10.1177/1087057112456877  0.317
2012 Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/Pnas.1200037109  0.351
2012 Sun H, Xia M, Austin CP, Huang R. Paradigm shift in toxicity testing and modeling. The Aaps Journal. 14: 473-80. PMID 22528508 DOI: 10.1208/s12248-012-9358-1  0.349
2012 Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin CP, Xia M. Application of a homogenous membrane potential assay to assess mitochondrial function. Physiological Genomics. 44: 495-503. PMID 22433785 DOI: 10.1152/physiolgenomics.00161.2011  0.318
2012 Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/Journal.Pone.0029861  0.376
2012 Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/Toxsci/Kfs023  0.37
2012 Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Research. 72: 1055-8. PMID 22246671 DOI: 10.1158/0008-5472.CAN-11-3439  0.323
2011 Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5239-43. PMID 21831635 DOI: 10.1016/j.bmcl.2011.07.043  0.315
2011 Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/Jm200497T  0.312
2011 Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (New York, N.Y.). 333: 724-9. PMID 21817045 DOI: 10.1126/Science.1205216  0.358
2011 Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cellular and Molecular Neurobiology. 31: 901-7. PMID 21598037 DOI: 10.1007/s10571-011-9689-y  0.359
2011 Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199  0.351
2011 Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/Aac.00618-10  0.367
2010 Shukla SJ, Huang R, Austin CP, Xia M. The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discovery Today. 15: 997-1007. PMID 20708096 DOI: 10.1016/j.drudis.2010.07.007  0.353
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015  0.309
2010 Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical Pharmacology. 79: 1272-80. PMID 20067776 DOI: 10.1016/j.bcp.2009.12.021  0.33
2010 Shen M, Zhang Y, Wiestner AU, Ashlock MA, Austin CP, Auld DS. Abstract 3685: A strategy to identify therapeutic candidates for chronic lymphocytic leukemia from a library of FDA approved drugs Cancer Research. 70: 3685-3685. DOI: 10.1158/1538-7445.Am10-3685  0.403
2009 Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin CP, Inglese J. Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Molecular Cancer. 8: 117. PMID 20003191 DOI: 10.1186/1476-4598-8-117  0.348
2009 Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/Nbt.1581  0.347
2009 Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/Toxsci/Kfp231  0.32
2009 Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. A high-throughput approach for identification of novel general anesthetics. Plos One. 4: e7150. PMID 19777064 DOI: 10.1371/Journal.Pone.0007150  0.344
2009 Norton JT, Titus SA, Dexter D, Austin CP, Zheng W, Huang S. Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening. 14: 1045-53. PMID 19762548 DOI: 10.1177/1087057109343120  0.378
2009 Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 5: 765-71. PMID 19734910 DOI: 10.1038/Nchembio.215  0.315
2009 Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/B902021G  0.358
2009 Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/J.Ab.2009.07.003  0.346
2009 Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/J.Bmc.2009.05.054  0.371
2009 Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123  0.333
2009 Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. Plos One. 4: e5740. PMID 19484131 DOI: 10.1371/journal.pone.0005740  0.375
2009 Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3686-92. PMID 19464886 DOI: 10.1016/J.Bmcl.2009.01.057  0.301
2009 Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114  0.357
2008 Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977  0.364
2008 Kimple AJ, Yasgar A, Hughes M, Jadhav A, Willard FS, Muller RE, Austin CP, Inglese J, Ibeanu GC, Siderovski DP, Simeonov A. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Combinatorial Chemistry & High Throughput Screening. 11: 396-409. PMID 18537560 DOI: 10.2174/138620708784534770  0.333
2008 Cho MH, Niles A, Huang R, Inglese J, Austin CP, Riss T, Xia M. A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicology in Vitro : An International Journal Published in Association With Bibra. 22: 1099-106. PMID 18400464 DOI: 10.1016/j.tiv.2008.02.013  0.352
2008 Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nature Medicine. 14: 407-12. PMID 18345010 DOI: 10.1038/Nm1737  0.317
2008 Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. Plos Neglected Tropical Diseases. 2: e127. PMID 18235848 DOI: 10.1371/Journal.Pntd.0000127  0.387
2008 Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786  0.351
2008 Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry. 375: 237-48. PMID 18211814 DOI: 10.1016/J.Ab.2007.12.028  0.378
2008 Simeonov A, Yasgar A, Jadhav A, Lokesh GL, Klumpp C, Michael S, Austin CP, Natarajan A, Inglese J. Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Analytical Biochemistry. 375: 60-70. PMID 18158907 DOI: 10.1016/J.Ab.2007.11.039  0.358
2008 Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, ... ... Austin CP, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/J.Bmcl.2007.10.100  0.359
2007 Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/Adt.2006.048  0.366
2004 Austin CP, Brady LS, Insel TR, Collins FS. NIH Molecular Libraries Initiative. Science (New York, N.Y.). 306: 1138-9. PMID 15542455 DOI: 10.1126/Science.1105511  0.369
2003 Austin CP. The completed human genome: implications for chemical biology. Current Opinion in Chemical Biology. 7: 511-5. PMID 12941427 DOI: 10.1016/S1367-5931(03)00083-8  0.301
2000 Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis with retroviral vectors. Methods in Enzymology. 327: 118-45. PMID 11044979 DOI: 10.1016/S0076-6879(00)27272-8  0.589
1998 Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis using retroviral vectors. Methods (San Diego, Calif.). 14: 393-406. PMID 9608510 DOI: 10.1006/Meth.1998.0594  0.592
1996 Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 93: 589-95. PMID 8570600 DOI: 10.1073/Pnas.93.2.589  0.686
1995 Austin CP, Feldman DE, Ida JA, Cepko CL. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development (Cambridge, England). 121: 3637-50. PMID 8582277  0.492
1994 Austin CP, Cepko CL. Retrovirus mediated gene transduction into the vertebrate CNS. Gene Therapy. 1: S6-9. PMID 8542405  0.415
1993 Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 225: 933-60. PMID 8231895 DOI: 10.1016/0076-6879(93)25059-B  0.556
1991 Misson JP, Austin CP, Takahashi T, Cepko CL, Caviness VS. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex (New York, N.Y. : 1991). 1: 221-9. PMID 1668365  0.439
1990 Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S. Studies of cortical development using retrovirus vectors. Cold Spring Harbor Symposia On Quantitative Biology. 55: 265-78. PMID 2132820 DOI: 10.1101/Sqb.1990.055.01.029  0.529
1990 Austin CP, Cepko CL. Cellular migration patterns in the developing mouse cerebral cortex. Development (Cambridge, England). 110: 713-32. PMID 2088716  0.443
Low-probability matches (unlikely to be authored by this person)
2019 Boycott KM, Lau LP, Cutillo CM, Austin CP. International collaborative actions and transparency to understand, diagnose, and develop therapies for rare diseases. Embo Molecular Medicine. PMID 30979709 DOI: 10.15252/emmm.201910486  0.3
2011 Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicology and Applied Pharmacology. 252: 250-8. PMID 21362439 DOI: 10.1016/J.Taap.2011.02.016  0.298
2007 Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, Auld DS. High-throughput screening assays for the identification of chemical probes. Nature Chemical Biology. 3: 466-79. PMID 17637779 DOI: 10.1038/nchembio.2007.17  0.297
2011 Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environmental and Molecular Mutagenesis. 52: 547-61. PMID 21538559 DOI: 10.1002/em.20656  0.296
2009 MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. Monitoring compound integrity with cytochrome P450 assays and qHTS. Journal of Biomolecular Screening. 14: 538-46. PMID 19483146 DOI: 10.1177/1087057109336954  0.295
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/Ng0904-921  0.295
2016 Lochmüller H, Le Cam Y, Jonker AH, Lau LP, Baynam G, Kaufmann P, Lasko P, Dawkins HJ, Austin CP, Boycott KM. 'IRDiRC Recognized Resources': a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases. European Journal of Human Genetics : Ejhg. PMID 27782107 DOI: 10.1038/ejhg.2016.137  0.295
2009 Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. A new resorufin-based alpha-glucosidase assay for high-throughput screening. Analytical Biochemistry. 390: 79-84. PMID 19371716 DOI: 10.1016/J.Ab.2009.04.010  0.295
2009 Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.Can-09-0891  0.295
2013 Attene-Ramos MS, Miller N, Huang R, Michael S, Itkin M, Kavlock RJ, Austin CP, Shinn P, Simeonov A, Tice RR, Xia M. The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discovery Today. 18: 716-23. PMID 23732176 DOI: 10.1016/j.drudis.2013.05.015  0.294
2012 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Finkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. The Journal of Biological Chemistry. 287: 39349-60. PMID 23035117 DOI: 10.1074/Jbc.M112.357707  0.294
2018 Kaufmann P, Pariser AR, Austin C. From scientific discovery to treatments for rare diseases - the view from the National Center for Advancing Translational Sciences - Office of Rare Diseases Research. Orphanet Journal of Rare Diseases. 13: 196. PMID 30400963 DOI: 10.1186/s13023-018-0936-x  0.291
2019 Baynam GS, Groft S, van der Westhuizen FH, Gassman SD, du Plessis K, Coles EP, Selebatso E, Selebatso M, Gaobinelwe B, Selebatso T, Joel D, Llera VA, Vorster BC, Wuebbels B, Djoudalbaye B, ... Austin CP, et al. A call for global action for rare diseases in Africa. Nature Genetics. PMID 31873296 DOI: 10.1038/S41588-019-0552-2  0.291
2017 Cutillo CM, Austin CP, Groft SC. A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC). Advances in Experimental Medicine and Biology. 1031: 349-369. PMID 29214582 DOI: 10.1007/978-3-319-67144-4_20  0.291
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Austin CP, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060  0.289
2017 Julkowska D, Austin CP, Cutillo CM, Gancberg D, Hager C, Halftermeyer J, Jonker AH, Lau LPL, Norstedt I, Rath A, Schuster R, Simelyte E, van Weely S. The importance of international collaboration for rare diseases research-a European perspective. Gene Therapy. PMID 28440796 DOI: 10.1038/gt.2017.29  0.289
2019 Menetski JP, Hoffmann S, Cush S, Kamphaus TN, Austin CP, Herrling P, Wagner JA. The FNIH Biomarkers Consortium: Past Accomplishments and New Strategic Direction. Clinical Pharmacology and Therapeutics. PMID 30648736 DOI: 10.1002/cpt.1362  0.288
2018 Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, ... ... Austin CP, et al. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environmental Health Perspectives. 126: 077010. PMID 30059008 DOI: 10.1289/EHP2589  0.288
2013 Sun H, Xia M, Shahane SA, Jadhav A, Austin CP, Huang R. Are hERG channel blockers also phospholipidosis inducers? Bioorganic & Medicinal Chemistry Letters. 23: 4587-90. PMID 23856051 DOI: 10.1016/j.bmcl.2013.06.034  0.288
2009 Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ. Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorganic & Medicinal Chemistry Letters. 19: 6700-5. PMID 19837585 DOI: 10.1016/J.Bmcl.2009.09.121  0.287
2004 Austin CP. The impact of the completed human genome sequence on the development of novel therapeutics for human disease. Annual Review of Medicine. 55: 1-13. PMID 14746506 DOI: 10.1146/annurev.med.55.091902.104426  0.287
2007 Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ. N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorganic & Medicinal Chemistry Letters. 17: 5783-9. PMID 17827006 DOI: 10.1016/J.Bmcl.2007.08.050  0.286
2009 Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. Analytical and Bioanalytical Chemistry. 394: 1903-9. PMID 19521690 DOI: 10.1007/S00216-009-2879-5  0.285
2012 Chen CZ, Sobczak K, Hoskins J, Southall N, Marugan JJ, Zheng W, Thornton CA, Austin CP. Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. Analytical and Bioanalytical Chemistry. 402: 1889-98. PMID 22218462 DOI: 10.1007/S00216-011-5604-0  0.285
2017 Austin CP, Cutillo CM, Lau LP, Jonker AH, Rath A, Julkowska D, Thomson D, Terry S, de Montleau B, Ardigò D, Hivert V, Boycott KM, Baynam G, Kaufmann P, Taruscio D, et al. Future of Rare Diseases Research 2017-2027: an IRDiRC Perspective. Clinical and Translational Science. PMID 28796445 DOI: 10.1111/cts.12500  0.283
2016 Walkley SU, Davidson CD, Jacoby J, Marella PD, Ottinger EA, Austin CP, Porter FD, Vite CH, Ory DS. Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease. Orphanet Journal of Rare Diseases. 11: 161. PMID 27903269 DOI: 10.1186/S13023-016-0540-X  0.283
2013 Teng C, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions. 203: 556-64. PMID 23562765 DOI: 10.1016/J.Cbi.2013.03.013  0.282
2019 Menetski JP, Austin CP, Brady LS, Eakin G, Leptak C, Meltzer A, Wagner JA. The FNIH Biomarkers Consortium embraces the BEST. Nature Reviews. Drug Discovery. 18: 567-568. PMID 31367046 DOI: 10.1038/d41573-019-00015-w  0.281
2013 Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/Ncomms3044  0.28
2008 Skoumbourdis AP, Huang R, Southall N, Leister W, Guo V, Cho MH, Inglese J, Nirenberg M, Austin CP, Xia M, Thomas CJ. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters. 18: 1297-303. PMID 18243697 DOI: 10.1016/J.Bmcl.2008.01.028  0.277
2015 Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, Pattaradilokrat S, Martin S, Qi Y, Nair SC, Bolland S, Cohen JI, Austin CP, Long CA, Myers TG, et al. Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. Cell Reports. PMID 26190101 DOI: 10.1016/J.Celrep.2015.06.058  0.273
2010 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Sidransky E, Aungst RA, Liu K, Sadhukhan SK, Austin CP. Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. European Journal of Medicinal Chemistry. 45: 1880-97. PMID 20206419 DOI: 10.1016/J.Ejmech.2010.01.027  0.27
2007 Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 13192-7. PMID 17670938 DOI: 10.1073/Pnas.0705637104  0.269
2017 Dawkins HJ, Draghia-Akli R, Lasko P, Lau LP, Jonker AH, Cutillo CM, Rath A, Boycott KM, Baynam G, Lochmüller H, Kaufmann P, Cam YL, Hivert V, Austin CP. Progress in rare diseases research 2010-2016: an IRDiRC perspective. Clinical and Translational Science. PMID 28796411 DOI: 10.1111/cts.12501  0.266
2017 Ory DS, Ottinger EA, Farhat NY, King KA, Jiang X, Weissfeld L, Berry-Kravis E, Davidson CD, Bianconi S, Keener LA, Rao R, Soldatos A, Sidhu R, Walters KA, Xu X, ... ... Austin CP, et al. Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial. Lancet (London, England). PMID 28803710 DOI: 10.1016/S0140-6736(17)31465-4  0.265
2017 Lochmüller H, Torrent I Farnell J, Le Cam Y, Jonker AH, Lau LP, Baynam G, Kaufmann P, Dawkins HJ, Lasko P, Austin CP, Boycott KM. The International Rare Diseases Research Consortium: Policies and Guidelines to maximize impact. European Journal of Human Genetics : Ejhg. PMID 29158551 DOI: 10.1038/s41431-017-0008-z  0.262
2017 Baynam G, Bowman F, Lister K, Walker CE, Pachter N, Goldblatt J, Boycott KM, Gahl WA, Kosaki K, Adachi T, Ishii K, Mahede T, McKenzie F, Townshend S, Slee J, ... ... Austin CP, et al. Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework. Advances in Experimental Medicine and Biology. 1031: 55-94. PMID 29214566 DOI: 10.1007/978-3-319-67144-4_4  0.261
2012 Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490: 187-91. PMID 23060188 DOI: 10.1038/Nature11556  0.258
2020 Huang R, Xu M, Zhu H, Chen CZ, Lee EM, He S, Shamim K, Bougie D, Huang W, Hall MD, Lo D, Simeonov A, Austin CP, Qiu X, Tang H, et al. Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32766591 DOI: 10.1101/2020.07.27.223578  0.257
2016 Gilliland CT, Zuk D, Kocis P, Johnson M, Hay S, Hajduch M, Bietrix F, Aversa G, Austin CP, Ussi AE. Putting translational science on to a global stage. Nature Reviews. Drug Discovery. 15: 217-8. PMID 27032820 DOI: 10.1038/nrd.2016.33  0.256
2009 Dorjsuren D, Wilson DM, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Research. 37: e128. PMID 19684079 DOI: 10.1093/Nar/Gkp641  0.255
2018 Perry ME, Valdes KM, Wilder E, Austin CP, Brooks PJ. Genome editing to 're-write' wrongs. Nature Reviews. Drug Discovery. PMID 29930285 DOI: 10.1038/nrd.2018.91  0.252
2021 Huang R, Xu M, Zhu H, Chen CZ, Zhu W, Lee EM, He S, Zhang L, Zhao J, Shamim K, Bougie D, Huang W, Xia M, Hall MD, Lo D, ... ... Austin CP, et al. Biological activity-based modeling identifies antiviral leads against SARS-CoV-2. Nature Biotechnology. PMID 33623157 DOI: 10.1038/s41587-021-00839-1  0.249
2012 Shukla SJ, Huang R, Simmons SO, Tice RR, Witt KL, Vanleer D, Ramabhadran R, Austin CP, Xia M. Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environmental Health Perspectives. 120: 1150-6. PMID 22551509 DOI: 10.1289/ehp.1104709  0.249
2020 Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Needleman KIM, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Publisher Correction: Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. Nature Reviews. Drug Discovery. PMID 31913355 DOI: 10.1038/s41573-019-0059-7  0.245
2009 Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening. 14: 1216-27. PMID 19828774 DOI: 10.1177/1087057109349355  0.237
2011 Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. Pharmacology, Biochemistry, and Behavior. 98: 349-55. PMID 21296104 DOI: 10.1016/J.Pbb.2011.02.001  0.237
2006 Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proceedings of the National Academy of Sciences of the United States of America. 103: 11473-8. PMID 16864780 DOI: 10.1073/pnas.0604348103  0.236
2011 Leister KP, Huang R, Goodwin BL, Chen A, Austin CP, Xia M. Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells. Current Chemical Genomics. 5: 21-9. PMID 21643507 DOI: 10.2174/1875397301105010021  0.236
2008 Liu K, Titus S, Southall N, Zhu P, Inglese J, Austin CP, Zheng W. Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Current Chemical Genomics. 1: 70-8. PMID 20161830 DOI: 10.2174/1875397300801010070  0.236
2012 Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proceedings of the National Academy of Sciences of the United States of America. 109: 5423-8. PMID 22431602 DOI: 10.1073/Pnas.1114278109  0.236
2008 Michael S, Auld D, Klumpp C, Jadhav A, Zheng W, Thorne N, Austin CP, Inglese J, Simeonov A. A robotic platform for quantitative high-throughput screening. Assay and Drug Development Technologies. 6: 637-57. PMID 19035846 DOI: 10.1089/adt.2008.150  0.235
2009 Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proceedings of the National Academy of Sciences of the United States of America. 106: 2412-7. PMID 19196967 DOI: 10.1073/Pnas.0813020106  0.235
2021 Chen Y, Tristan CA, Chen L, Jovanovic VM, Malley C, Chu PH, Ryu S, Deng T, Ormanoglu P, Tao D, Fang Y, Slamecka J, Hong H, LeClair CA, Michael S, ... Austin CP, et al. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nature Methods. PMID 33941937 DOI: 10.1038/s41592-021-01126-2  0.234
2009 Xia M, Guo V, Huang R, Inglese J, Nirenberg M, Austin CP. A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway. Current Chemical Genomics. 3: 7-12. PMID 19936037 DOI: 10.2174/1875397300903010007  0.231
2013 Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/Jneurosci.4742-12.2013  0.231
2008 Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chemical Research in Toxicology. 21: 659-67. PMID 18281954 DOI: 10.1021/Tx700365E  0.228
2011 Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine. 3: 80ps16. PMID 21525397 DOI: 10.1126/Scitranslmed.3001862  0.228
2011 Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environmental Health Perspectives. 119: 1142-8. PMID 21543282 DOI: 10.1289/ehp.1002952  0.227
2008 Zhu PJ, Zheng W, Auld DS, Jadhav A, Macarthur R, Olson KR, Peng K, Dotimas H, Austin CP, Inglese J. A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS. Combinatorial Chemistry & High Throughput Screening. 11: 545-59. PMID 18694391 DOI: 10.2174/138620708785204045  0.224
2009 Shukla SJ, Nguyen DT, Macarthur R, Simeonov A, Frazee WJ, Hallis TM, Marks BD, Singh U, Eliason HC, Printen J, Austin CP, Inglese J, Auld DS. Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay and Drug Development Technologies. 7: 143-69. PMID 19505231 DOI: 10.1089/adt.2009.193  0.223
2021 Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, ... ... Austin CP, et al. Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit. The Journal of Infectious Diseases. PMID 34111271 DOI: 10.1093/infdis/jiab305  0.22
2010 Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Research. 38: e11. PMID 19897549 DOI: 10.1093/Nar/Gkp899  0.22
2012 Sun H, Shahane S, Xia M, Austin CP, Huang R. Structure based model for the prediction of phospholipidosis induction potential of small molecules. Journal of Chemical Information and Modeling. 52: 1798-805. PMID 22725677 DOI: 10.1021/ci3001875  0.219
2020 Richard AM, Huang R, Waidyanatha S, Shinn P, Collins BJ, Thillainadarajah I, Grulke CM, Williams AJ, Lougee RR, Judson RS, Houck KA, Shobair M, Yang C, Rathman JF, Yasgar A, ... ... Austin CP, et al. The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology. Chemical Research in Toxicology. PMID 33140634 DOI: 10.1021/acs.chemrestox.0c00264  0.219
2011 Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M. Identification of clinically used drugs that activate pregnane X receptors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 151-9. PMID 20966043 DOI: 10.1124/dmd.110.035105  0.217
2017 Johnston SC, Austin CP, Lewis-Hall F. Voluntary Site Accreditation - Improving the Execution of Multicenter Clinical Trials. The New England Journal of Medicine. 377: 1414-1415. PMID 29020596 DOI: 10.1056/NEJMp1709203  0.213
2010 Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. Journal of Medicinal Chemistry. 53: 37-51. PMID 19908840 DOI: 10.1021/Jm901070C  0.213
2008 Urban DJ, Zheng W, Goker-Alpan O, Jadhav A, Lamarca ME, Inglese J, Sidransky E, Austin CP. Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. Combinatorial Chemistry & High Throughput Screening. 11: 817-24. PMID 19075603 DOI: 10.2174/138620708786734244  0.212
2013 Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, Schnellmann RG, Beeson CC, Tice RR, Austin CP, Xia M. Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. Chemical Research in Toxicology. 26: 1323-32. PMID 23895456 DOI: 10.1021/Tx4001754  0.211
2011 Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. Journal of Medicinal Chemistry. 54: 1033-58. PMID 21250698 DOI: 10.1021/Jm1008902  0.211
2012 Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K  0.211
2017 Wagner J, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. A dynamic map for learning, communicating, navigating and improving therapeutic development. Nature Reviews. Drug Discovery. PMID 29269942 DOI: 10.1038/nrd.2017.217  0.211
2007 Feng BY, Simeonov A, Jadhav A, Babaoglu K, Inglese J, Shoichet BK, Austin CP. A high-throughput screen for aggregation-based inhibition in a large compound library. Journal of Medicinal Chemistry. 50: 2385-90. PMID 17447748 DOI: 10.1021/Jm061317Y  0.208
2011 Sun H, Veith H, Xia M, Austin CP, Huang R. Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. Journal of Chemical Information and Modeling. 51: 2474-81. PMID 21905670 DOI: 10.1021/ci200311w  0.206
2015 Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR, Kavlock RJ, Kitano H, Lidbury BA, Muotri AR, Peng SQ, Sakharov D, Seidle T, et al. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environmental Health Perspectives. 123: A268-72. PMID 26523530 DOI: 10.1289/Ehp.1510345  0.203
2008 Babaoglu K, Simeonov A, Irwin JJ, Nelson ME, Feng B, Thomas CJ, Cancian L, Costi MP, Maltby DA, Jadhav A, Inglese J, Austin CP, Shoichet BK. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. Journal of Medicinal Chemistry. 51: 2502-11. PMID 18333608 DOI: 10.1021/Jm701500E  0.201
2013 Tice RR, Austin CP, Kavlock RJ, Bucher JR. Improving the human hazard characterization of chemicals: a Tox21 update. Environmental Health Perspectives. 121: 756-65. PMID 23603828 DOI: 10.1289/ehp.1205784  0.201
2018 Austin CP, Colvis CM, Southall NT. Deconstructing the Translational Tower of Babel. Clinical and Translational Science. PMID 30412342 DOI: 10.1111/Cts.12595  0.201
2006 Parker CN, Shamu CE, Kraybill B, Austin CP, Bajorath J. Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? Drug Discovery Today. 11: 863-5. PMID 16997135 DOI: 10.1016/j.drudis.2006.08.006  0.196
2013 Dehdashti SJ, Zheng W, Gever JR, Wilhelm R, Nguyen DT, Sittampalam G, McKew JC, Austin CP, Prusiner SB. A high-throughput screening assay for determining cellular levels of total tau protein. Current Alzheimer Research. 10: 679-87. PMID 23905996 DOI: 10.2174/15672050113109990143  0.192
2008 Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay and Drug Development Technologies. 6: 551-5. PMID 18665782 DOI: 10.1089/adt.2008.149  0.192
2013 Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. Acs Medicinal Chemistry Letters. 4: 79-84. PMID 24040486 DOI: 10.1021/Ml300286H  0.19
2015 Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environmental Health Perspectives. 123: 49-56. PMID 25302578 DOI: 10.1289/ehp.1408642  0.189
2009 Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Molecular Cancer Therapeutics. 8: 240-8. PMID 19139134 DOI: 10.1158/1535-7163.Mct-08-0878  0.186
2012 Titus SA, Southall N, Marugan J, Austin CP, Zheng W. High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Current Chemical Genomics. 6: 79-86. PMID 23346268 DOI: 10.2174/1875397301206010079  0.182
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G  0.181
2013 Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR, et al. Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. Altex. 30: 51-6. PMID 23338806 DOI: 10.14573/Altex.2013.1.051  0.18
2019 Duncan KK, Rudnicki DD, Austin CP, Tagle DA. Exploring Novel Biologically-Relevant Chemical Space Through Artificial Intelligence: The NCATS ASPIRE Program. Frontiers in Robotics and Ai. 6: 143. PMID 33501158 DOI: 10.3389/frobt.2019.00143  0.178
2008 Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Characterization of chemical libraries for luciferase inhibitory activity. Journal of Medicinal Chemistry. 51: 2372-86. PMID 18363348 DOI: 10.1021/Jm701302V  0.177
2010 Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/Jm901069A  0.177
2008 Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspectives. 116: 284-91. PMID 18335092 DOI: 10.1289/Ehp.10727  0.174
2006 Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods in Enzymology. 414: 566-89. PMID 17110211 DOI: 10.1016/S0076-6879(06)14029-X  0.168
2009 Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/Bi9006435  0.167
2009 Brimacombe KR, Hall MD, Auld DS, Inglese J, Austin CP, Gottesman MM, Fung KL. A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay and Drug Development Technologies. 7: 233-49. PMID 19548831 DOI: 10.1089/Adt.2008.165  0.166
2014 Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/Nar/Gku275  0.162
2008 Yasgar A, Shinn P, Jadhav A, Auld D, Michael S, Zheng W, Austin CP, Inglese J, Simeonov A. Compound Management for Quantitative High-Throughput Screening. Jala (Charlottesville, Va.). 13: 79-89. PMID 18496600 DOI: 10.1016/j.jala.2007.12.004  0.161
2009 Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry. 52: 1450-8. PMID 19215089 DOI: 10.1021/Jm8014525  0.16
2013 Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Correction: Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs Plos One. 8. DOI: 10.1371/annotation/e2536fcb-3ab3-44a0-8eab-91aaeb8e49b6  0.159
2011 Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W. The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm. 2: 1016-1020. PMID 22408719 DOI: 10.1039/C1Md00145K  0.156
2009 Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, et al. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. Journal of Medicinal Chemistry. 52: 6474-83. PMID 19761212 DOI: 10.1021/Jm901021K  0.156
2003 Figueroa DJ, Borish L, Baramki D, Philip G, Austin CP, Evans JF. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 33: 1380-8. PMID 14519144 DOI: 10.1046/j.1365-2222.2003.01786.x  0.155
2009 Thomas CJ, Auld DS, Huang R, Huang W, Jadhav A, Johnson RL, Leister W, Maloney DJ, Marugan JJ, Michael S, Simeonov A, Southall N, Xia M, Zheng W, Inglese J, ... Austin CP, et al. The pilot phase of the NIH Chemical Genomics Center. Current Topics in Medicinal Chemistry. 9: 1181-93. PMID 19807664 DOI: 10.2174/156802609789753644  0.151
2010 Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ. Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environmental Science & Technology. 44: 5979-85. PMID 20602530 DOI: 10.1021/Es102150Z  0.149
2022 Korn D, Thieme AJ, Alves VM, Yeakey M, Borba JVVB, Capuzzi SJ, Fecho K, Bizon C, Edwards SW, Chirkova R, Colvis CM, Southall NT, Austin CP, Muratov EN, Tropsha A. Defining clinical outcome pathways. Drug Discovery Today. PMID 35182735 DOI: 10.1016/j.drudis.2022.02.008  0.147
1999 Chen F, Figueroa DJ, Marmorstein AD, Zhang Q, Petrukhin K, Caskey CT, Austin CP. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 15149-54. PMID 10611353 DOI: 10.1073/Pnas.96.26.15149  0.147
2022 Faupel-Badger JM, Vogel AL, Hussain SF, Austin CP, Hall MD, Ness E, Sanderson P, Terse PS, Xu X, Balakrishnan K, Patnaik S, Marugan JJ, Rudloff U, Ferrer M. Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences. Journal of Clinical and Translational Science. 6: e66. PMID 35754433 DOI: 10.1017/cts.2022.374  0.146
2009 Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/Pnas.0904506106  0.145
2002 Figueroa DJ, Morris JA, Ma L, Kandpal G, Chen E, Li YM, Austin CP. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiology of Disease. 9: 49-60. PMID 11848684 DOI: 10.1006/nbdi.2001.0447  0.143
2021 Austin CP. Opportunities and Challenges in Translational Science. Clinical and Translational Science. PMID 33982407 DOI: 10.1111/cts.13055  0.139
1998 Petrukhin K, Koisti MJ, Bakall B, Li W, Xie G, Marknell T, Sandgren O, Forsman K, Holmgren G, Andreasson S, Vujic M, Bergen AA, McGarty-Dugan V, Figueroa D, Austin CP, et al. Identification of the gene responsible for Best macular dystrophy. Nature Genetics. 19: 241-7. PMID 9662395 DOI: 10.1038/915  0.138
2003 Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Conn PJ, Conn JP, Pettibone DJ, Austin C, Sur C. Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Analytical Biochemistry. 321: 31-7. PMID 12963052 DOI: 10.1016/S0003-2697(03)00431-7  0.137
1998 AUSTIN C. The genomics revolution and its implications for new drug discovery American Journal of Hypertension. 11: 242A. DOI: 10.1016/S0895-7061(97)91608-3  0.137
2019 Sittampalam GS, Rudnicki DD, Tagle DA, Simeonov A, Austin CP. Mapping biologically active chemical space to accelerate drug discovery. Nature Reviews. Drug Discovery. 18: 83-84. PMID 30710133 DOI: 10.1038/d41573-018-00007-2  0.134
2008 Simeonov A, Jadhav A, Thomas CJ, Wang Y, Huang R, Southall NT, Shinn P, Smith J, Austin CP, Auld DS, Inglese J. Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry. 51: 2363-71. PMID 18363325 DOI: 10.1021/Jm701301M  0.134
2002 Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, et al. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics. 79: 785-92. PMID 12036292 DOI: 10.1006/geno.2002.6771  0.133
2021 Austin CP, Mount BA, Colvis CM. Envisioning an actionable research agenda to facilitate repurposing of off-patent drugs. Nature Reviews. Drug Discovery. PMID 34045734 DOI: 10.1038/d41573-021-00090-y  0.133
2013 Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/Jm400904M  0.13
2011 Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, VanLeer D, Auld DS, Austin CP, Xia M. Identification of clinically utilized drugs that activate pregnane X receptors (Drug Metabolism and Disposition (2011) 39 (151-159)) Drug Metabolism and Disposition. 39: 351. DOI: 10.1124/dmd.39.2.351  0.128
2011 Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. The Journal of Biological Chemistry. 286: 11895-908. PMID 21321127 DOI: 10.1074/jbc.M110.200436  0.128
2002 Parent SA, Zhang T, Chrebet G, Clemas JA, Figueroa DJ, Ky B, Blevins RA, Austin CP, Rosen H. Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Gene. 293: 33-46. PMID 12137941 DOI: 10.1016/S0378-1119(02)00722-9  0.127
1999 Liu Q, Pong SS, Zeng Z, Zhang Q, Howard AD, Williams DL, Davidoff M, Wang R, Austin CP, McDonald TP, Bai C, George SR, Evans JF, Caskey CT. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. Biochemical and Biophysical Research Communications. 266: 174-8. PMID 10581185 DOI: 10.1006/Bbrc.1999.1796  0.127
2016 Abera MB, Xiao J, Nofziger J, Titus S, Southall N, Zheng W, Moritz KE, Ferrer M, Cherry JJ, Androphy EJ, Wang A, Xu X, Austin C, Fischbeck KH, Marugan JJ, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. Jci Insight. 1: e88427. PMID 27882347 DOI: 10.1172/Jci.Insight.88427  0.125
2006 Hobson J, Liu S, Rønø B, Zheng W, Zhu P, Austin C, Inglese J, Leppla S, Bugge T. ID: 296 Non-invasive, optical imaging of specific cell surface proteolytic activity in single living cells Journal of Thrombosis and Haemostasis. 4: 95-95. DOI: 10.1111/j.1538-7836.2006.00296.x  0.124
2018 Gan HM, Austin C, Linton S. Transcriptome-Guided Identification of Carbohydrate Active Enzymes (CAZy) from the Christmas Island Red Crab, Gecarcoidea natalis and a Vote for the Inclusion of Transcriptome-Derived Crustacean CAZys in Comparative Studies. Marine Biotechnology (New York, N.Y.). PMID 29995174 DOI: 10.1007/s10126-018-9836-2  0.123
2001 Hui Y, Yang G, Galczenski H, Figueroa DJ, Austin CP, Copeland NG, Gilbert DJ, Jenkins NA, Funk CD. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. The Journal of Biological Chemistry. 276: 47489-95. PMID 11591709 DOI: 10.1074/jbc.M107556200  0.122
2002 Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene. 296: 205-12. PMID 12383518  0.122
2010 Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay and Drug Development Technologies. 8: 367-79. PMID 20230302 DOI: 10.1089/Adt.2009.0245  0.121
2003 Woods JW, Tanen M, Figueroa DJ, Biswas C, Zycband E, Moller DE, Austin CP, Berger JP. Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons. Brain Research. 975: 10-21. PMID 12763589  0.121
2019 Gilliland CT, White J, Gee B, Kreeftmeijer-Vegter R, Bietrix F, Ussi AE, Hajduch M, Kocis P, Chiba N, Hirasawa R, Suematsu M, Bryans J, Newman S, Hall MD, Austin CP. The Fundamental Characteristics of a Translational Scientist. Acs Pharmacology & Translational Science. 2: 213-216. PMID 32259057 DOI: 10.1021/acsptsci.9b00022  0.118
2019 Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, et al. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. Learning Health Systems. 3: e10073. PMID 31245596 DOI: 10.1002/lrh2.10073  0.118
2007 Honson NS, Johnson RL, Huang W, Inglese J, Austin CP, Kuret J. Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease. 28: 251-60. PMID 17761424 DOI: 10.1016/J.Nbd.2007.07.018  0.118
2010 McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. Acs Chemical Neuroscience. 1: 559-574. PMID 21116448 DOI: 10.1021/Cn100040H  0.116
2001 Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, Liu Q. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochemical and Biophysical Research Communications. 284: 1189-93. PMID 11414709 DOI: 10.1006/Bbrc.2001.5098  0.113
2021 Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, ... ... Austin CP, et al. The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction. Medrxiv : the Preprint Server For Health Sciences. PMID 33469592 DOI: 10.1101/2021.01.12.21249511  0.113
2000 Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 97: 1230-5. PMID 10655513 DOI: 10.1073/pnas.97.3.1230  0.112
2022 Markossian S, Brimacombe KR, Sittampalam GS, Grossman A, Coussens NP, Inglese J, Auld DS, Chin W, Austin CP, Hall MD. The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation. Nature Reviews. Drug Discovery. PMID 36253455 DOI: 10.1038/d41573-022-00170-7  0.111
2009 Kajiyama H, Titus S, Austin CP, Chiotos K, Matsumoto T, Sakairi T, Kopp JB. Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. American Journal of Nephrology. 29: 153-63. PMID 18753740 DOI: 10.1159/000151770  0.111
2002 Blair IP, Adams LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35. Molecular Psychiatry. 7: 867-73. PMID 12232780 DOI: 10.1038/Sj.Mp.4001113  0.106
2001 Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, ... ... Austin CP, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genetics. 27: 89-93. PMID 11138005 DOI: 10.1038/83817  0.104
2002 Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, et al. A role for the melanocortin 4 receptor in sexual function. Proceedings of the National Academy of Sciences of the United States of America. 99: 11381-6. PMID 12172010 DOI: 10.1073/Pnas.172378699  0.103
2000 Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Austin CP, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/Jbc.M003490200  0.101
2001 Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, ... ... Austin CP, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proceedings of the National Academy of Sciences of the United States of America. 98: 7564-9. PMID 11404457 DOI: 10.1073/pnas.121170598  0.095
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/Nchembio.1867  0.095
2021 Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, ... ... Austin CP, et al. Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative. Jama Network Open. 4: e2116901. PMID 34255046 DOI: 10.1001/jamanetworkopen.2021.16901  0.093
2001 Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams DL, Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, ... ... Austin CP, et al. Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. The Journal of Biological Chemistry. 276: 36961-9. PMID 11481330 DOI: 10.1074/jbc.M105308200  0.092
2000 Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, ... ... Austin CP, et al. Identification of receptors for neuromedin U and its role in feeding. Nature. 406: 70-4. PMID 10894543 DOI: 10.1038/35017610  0.092
2003 Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Human Molecular Genetics. 12: 1591-608. PMID 12812986  0.091
2016 Austin C, Kusumoto F. The application of Big Data in medicine: current implications and future directions. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 26814841 DOI: 10.1007/s10840-016-0104-y  0.091
2022 Faupel-Badger JM, Vogel AL, Austin CP, Rutter JL. Advancing translational science education. Clinical and Translational Science. PMID 36045637 DOI: 10.1111/cts.13390  0.09
2020 Brooks P, Ottinger E, Portero D, Lomash RM, Alimardanov A, Terse P, Xu X, Chandler RJ, Geist Hauserman J, Esposito E, Bönnemann CG, Venditti CP, Austin C, Pariser A, Lo DC. The Platform Vector Gene Therapies (PaVe-GT) Project: Increasing the efficiency of adeno-associated virus (AAV) gene therapy clinical trial startup. Human Gene Therapy. PMID 32993373 DOI: 10.1089/hum.2020.259  0.089
2000 Figueroa DJ, Hess JF, Ky B, Brown SD, Sandig V, Hermanowski-Vosatka A, Twells RC, Todd JA, Austin CP. Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 48: 1357-68. PMID 10990489 DOI: 10.1177/002215540004801006  0.089
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/Nchembio1115-887C  0.089
2012 Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. Reply to Kojo: Mechanisms of antioxidant-induced DNA damage Proceedings of the National Academy of Sciences of the United States of America. 109: E2029. DOI: 10.1073/Pnas.1207795109  0.086
1999 Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658  0.086
2016 Austin C, Kusumoto F. Innovative pacing: Recent advances, emerging technologies, and future directions in cardiac pacing. Trends in Cardiovascular Medicine. PMID 27017442 DOI: 10.1016/j.tcm.2016.02.006  0.085
2002 Ma L, Liu Y, Ky B, Shughrue PJ, Austin CP, Morris JA. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 80: 662-72. PMID 12504857 DOI: 10.1006/geno.2002.7012  0.085
2017 Austin CP, Dawkins HJS. Medical research: Next decade's goals for rare diseases. Nature. 548: 158. PMID 28796211 DOI: 10.1038/548158c  0.084
2016 Collins FS, Anderson JM, Austin CP, Battey JF, Birnbaum LS, Briggs JP, Clayton JA, Cuthbert B, Eisinger RW, Fauci AS, Gallin JI, Gibbons GH, Glass RI, Gottesman MM, Gray PA, et al. Basic science: Bedrock of progress. Science (New York, N.Y.). 351: 1405. PMID 27013720 DOI: 10.1126/Science.351.6280.1405-A  0.083
2001 Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101  0.081
1999 Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, et al. Receptor for motilin identified in the human gastrointestinal system. Science (New York, N.Y.). 284: 2184-8. PMID 10381885 DOI: 10.1126/science.284.5423.2184  0.08
2010 Terry S, Austin C, Inglese J, Meeker D, Terry P. Assay, preclinical, and clinical brick walls and opportunities for system change through GRANDRx Assay and Drug Development Technologies. 8: 128-134. PMID 20307201 DOI: 10.1089/adt.2010.0802.rt  0.08
2010 Terry S, Austin C, Inglese J, Meeker D, Terry P. Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx. Assay and Drug Development Technologies. PMID 20233071 DOI: 10.1089/adt.2009.0802.rt  0.08
2023 Taj S, Hussain A, Sanekommu H, Miller B, Austin C, Kilada C, Dandu S, Ahsan E, Erler BS. Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma. Acg Case Reports Journal. 10: e01097. PMID 37434661 DOI: 10.14309/crj.0000000000001097  0.079
2009 Patnaik S, Dietz HC, Zheng W, Austin C, Marugan JJ. Multi-gram scale synthesis of FR180204. The Journal of Organic Chemistry. 74: 8870-3. PMID 19852504 DOI: 10.1021/Jo901835M  0.079
2023 Buse JB, Austin CP, Johnston SC, Lewis-Hall F, March AN, Shore CK, Tenaerts P, Rutter JL. A framework for assessing clinical trial site readiness. Journal of Clinical and Translational Science. 7: e151. PMID 37456265 DOI: 10.1017/cts.2023.541  0.078
1995 Cepko C, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 254: 387-419. PMID 8531701 DOI: 10.1016/0076-6879(95)54027-X  0.076
2015 Colvis CM, Austin CP. The NIH-industry new therapeutic uses pilot program: Demonstrating the power of crowdsourcing Assay and Drug Development Technologies. 13: 297-298. DOI: 10.1089/adt.2015.29006.cmcdrrr  0.075
2019 Mott MC, Austin CP, Bianchi DW, Cashion AK, Gordon JA, Heemskerk JE, Hodes RJ, Koob GF, Riley WT, Sieving PA, Shurtleff D, Somerman MJ, Volkow ND, Anderson KC, Owens DF, et al. The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 39: 774-775. PMID 30700523 DOI: 10.1523/Jneurosci.2742-18.2018  0.074
2022 Austin CP, Odak M, Douedi S, Patel SV. Supraventricular Tachycardia: An Atypical Presentation of Thyroid Storm. Cureus. 14: e25449. PMID 35774700 DOI: 10.7759/cureus.25449  0.073
2022 Amin T, Austin CP, Udongwo N, Wiseman K, Parhar AS, Chaughtai S. Iodinated Contrast-Induced Thyroid Storm With Concomitant Cardiac Tamponade: A Case Report. Cureus. 14: e28001. PMID 36134087 DOI: 10.7759/cureus.28001  0.072
2004 Austin CP, Ky B, Ma L, Morris JA, Shughrue PJ. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 124: 3-10. PMID 14960334 DOI: 10.1016/j.neuroscience.2003.11.010  0.071
2007 Gerhold D, Bagchi A, Lu M, Figueroa D, Keenan K, Holder D, Wang Y, Jin H, Connolly B, Austin C, Alonso-Galicia M. Androgens drive divergent responses to salt stress in male versus female rat kidneys. Genomics. 89: 731-44. PMID 17481853 DOI: 10.1016/j.ygeno.2007.01.009  0.07
2021 Herstein JJ, Degarege A, Stover D, Austin C, Schwedhelm MM, Lawler JV, Lowe JJ, Ramos AK, Donahue M. Characteristics of SARS-CoV-2 Transmission among Meat Processing Workers in Nebraska, USA, and Effectiveness of Risk Mitigation Measures. Emerging Infectious Diseases. 27. PMID 33591249 DOI: 10.3201/eid2704.204800  0.068
1993 Green AI, Austin CP. Psychopathology of pancreatic cancer. A psychobiologic probe. Psychosomatics. 34: 208-21. PMID 8493302 DOI: 10.1016/S0033-3182(93)71882-4  0.067
2018 Austin C, Kusumoto F. Updates in medical professional liability: a primer for electrophysiologists. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 30276591 DOI: 10.1007/s10840-018-0453-9  0.065
2020 Zhang X, Kurilla MG, Austin CP. The CTSA program's role in improving rural public health: Community-engaged disease prevention and health care innovation. Journal of Clinical and Translational Science. 4: 373-376. PMID 33244424 DOI: 10.1017/cts.2020.541  0.064
2008 Patel S, Novikova N, Beenders B, Austin C, Bellini M. Live images of RNA polymerase II transcription units Chromosome Research. 16: 223-232. PMID 18320360 DOI: 10.1007/S10577-007-1189-Z  0.063
2009 Birney E, Hudson TJ, Green ED, Gunter C, Eddy S, Rogers J, Harris JR, Ehrlich SD, Apweiler R, Austin CP, Berglund L, Bobrow M, Bountra C, Brookes AJ, et al. Prepublication data sharing. Nature. 461: 168-70. PMID 19741685 DOI: 10.1038/461168A  0.063
2009 Kavlock RJ, Austin CP, Tice RR. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Analysis : An Official Publication of the Society For Risk Analysis. 29: 485-7; discussion 49. PMID 19076321 DOI: 10.1111/j.1539-6924.2008.01168.x  0.06
2021 Livingstone KM, Tan MH, Abbott G, Duckham RL, Croft L, Ward J, McEvoy M, Keske MA, Austin C, Bowe SJ. Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study. Frontiers in Endocrinology. 12: 692677. PMID 34239500 DOI: 10.3389/fendo.2021.692677  0.059
2003 Shughrue PJ, Ky B, Austin CP. Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. The Journal of Comparative Neurology. 465: 372-84. PMID 12966562 DOI: 10.1002/cne.10846  0.058
2012 Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Jeffrey Conn P, Pettibone DJ, Austin C, Sura C. Corrigendum to “Development of a scintillation proximity assay for analysis of Na+/Cl− -dependent neurotransmitter transporter activity” [Anal. Biochem. 321 (2003) 31–37] Analytical Biochemistry. 429: 18. DOI: 10.1016/j.ab.2012.01.024  0.057
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang J, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Austin CP, et al. Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Nature Chemical Biology. 8: 1008-1008. DOI: 10.1038/Nchembio1212-1008B  0.057
2018 Ray JC, Burger C, Mergo P, Safford R, Blackshear J, Austin C, Fairweather D, Heckman MG, Zeiger T, Dubin M, Shapiro B. Pulmonary arterial stiffness assessed by cardiovascular magnetic resonance imaging is a predictor of mild pulmonary arterial hypertension. The International Journal of Cardiovascular Imaging. PMID 29934885 DOI: 10.1007/s10554-018-1397-y  0.054
2009 Austin C, Novikova N, Guacci V, Bellini M. Lampbrush chromosomes enable study of cohesin dynamics. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 17: 165-84. PMID 19308699 DOI: 10.1007/s10577-008-9015-9  0.054
2000 Uebele VN, Lagrutta A, Wade T, Figueroa DJ, Liu Y, McKenna E, Austin CP, Bennett PB, Swanson R. Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. The Journal of Biological Chemistry. 275: 23211-8. PMID 10766764 DOI: 10.1074/jbc.M910187199  0.052
2022 Taj S, Austin CP, Ahmed Z, Fareen N, Chaughtai Z, Pervaiz H, Chaughtai S. Lemierre's Syndrome: A Comeback Story. Cureus. 14: e25843. PMID 35832767 DOI: 10.7759/cureus.25843  0.051
2002 Blair IP, Adam LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. Stylized transcript map of chromosome 4q35 encompassing the locus for a bipolar disorder susceptibility gene. Molecular Psychiatry. 7: 669. PMID 12192607 DOI: 10.1038/Sj.Mp.4001154  0.051
2013 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders (Journal of Biological Chemistry (2012) 287, (39349-39360)) Journal of Biological Chemistry. 288: 296. DOI: 10.1074/Jbc.A112.357707  0.05
2007 Simeonov A, Yasgar A, Klumpp C, Zheng W, Shafqat N, Oppermann U, Austin CP, Inglese J. Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay and Drug Development Technologies. 5: 815-24. PMID 18078381 DOI: 10.1089/adt.2007.097  0.048
2017 Austin C, Burger C, Kane G, Safford R, Blackshear J, Ung R, Ray J, Alsaad A, Alassas K, Shapiro B. High-risk echocardiographic features predict mortality in pulmonary arterial hypertension. American Heart Journal. 189: 167-176. PMID 28625373 DOI: 10.1016/j.ahj.2017.04.013  0.047
2003 Zeng Z, McDonald TP, Wang R, Liu Q, Austin CP. Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata. Journal of Chemical Neuroanatomy. 25: 269-78. PMID 12842272  0.046
2021 Austin CP. Translational misconceptions. Nature Reviews. Drug Discovery. PMID 33462425 DOI: 10.1038/d41573-021-00008-8  0.046
2018 Austin CP. Translating translation. Nature Reviews. Drug Discovery. PMID 29674698 DOI: 10.1038/nrd.2018.27  0.045
1999 Austin CP, Holder DJ, Ma L, Mixson LA, Caskey CT. Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia. Molecular Psychiatry. 4: 261-6. PMID 10395216  0.044
2000 Liu Y, McKenna E, Figueroa DJ, Blevins R, Austin CP, Bennett PB, Swanson R. The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. Cytogenetics and Cell Genetics. 90: 60-3. PMID 11060447  0.044
2001 DiLella AG, Toner TJ, Austin CP, Connolly BM. Identification of genes differentially expressed in benign prostatic hyperplasia. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 49: 669-70. PMID 11304808  0.044
2022 Haines DE, Austin C, Kusumoto FM, Liu CH, Mounsey JP, Proto-Conroy K, Selzman KA. Heart Rhythm Society Policy Statement Update: Recommendations on the role of industry-employed allied professionals. Heart Rhythm. 20: 157-162. PMID 37264874 DOI: 10.1016/j.hrthm.2022.08.029  0.041
2004 Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes. 53: 597-607. PMID 14988243  0.041
2018 Rodgers G, Austin C, Anderson J, Pawlyk A, Colvis C, Margolis R, Baker J. Glimmers in illuminating the druggable genome. Nature Reviews. Drug Discovery. PMID 29348682 DOI: 10.1038/nrd.2017.252  0.04
2001 Figueroa DJ, Shi XP, Gardell SJ, Austin CP. Abetapp secretases are co-expressed with Abetapp in the pancreatic islets. Journal of Alzheimer's Disease : Jad. 3: 393-396. PMID 12214042 DOI: 10.3233/JAD-2001-3405  0.038
2003 Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. Neuroreport. 14: 951-4. PMID 12802181 DOI: 10.1097/01.wnr.0000074342.81633.63  0.037
2023 Taj S, Mujtaba M, Miller B, Dandu S, Austin CP, Ali Akbar U, Sanekommu H, Hossain MA. Role of Plasmapheresis in Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome. Cureus. 15: e35520. PMID 37007368 DOI: 10.7759/cureus.35520  0.032
2019 Tanaka ST, Paramsothy P, Thibadeau J, Wiener JS, Joseph DB, Cheng EY, Tu D, Austin C, Koh CJ, Wallis MC, Walker WO, Smith KA, Routh JC, Baum MA. Baseline Urinary Imaging in Infants Enrolled in Urologic Management to Preserve Initial Renal Function (UMPIRE) Protocol for Children with Spina Bifida. The Journal of Urology. PMID 30730412 DOI: 10.1097/JU.0000000000000141  0.027
2024 Deering TF, Catanzaro JN, Sandhu RK, Singleton M, Das S, Deyell MW, Mulpuru SK, Magnelli-Reyes CL, Koplan BA, Vergara GR, Austin C, Assis FR, Xiang K, Moore M, Smith AM. Heart Rhythm Society Quality Improvement Committee update. Heart Rhythm. 21: 241-243. PMID 38296459 DOI: 10.1016/j.hrthm.2023.11.014  0.027
2021 Austin CP, Jonson S, Kurilla MG. Foreword to the JCTS COVID-19 special issue. Journal of Clinical and Translational Science. 5: e103. PMID 34164155 DOI: 10.1017/cts.2021.400  0.026
2021 Goel R, Winchester DE, Austin C, Staples ED. Pneumopericardium Develops After Pacemaker Implantation. Texas Heart Institute Journal. 48. PMID 34665870 DOI: 10.14503/THIJ-19-7093  0.025
2013 Batton K, Moussa I, Blackshear J, Mergo P, Austin C, Shapiro B. Use of cardiac magnetic resonance imaging for alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Acute Cardiac Care. 15: 44-6. PMID 23663012 DOI: 10.3109/17482941.2013.781188  0.024
2015 Austin C, Alassas K, Burger C, Safford R, Pagan R, Duello K, Kumar P, Zeiger T, Shapiro B. Echocardiographic assessment of estimated right atrial pressure and size predicts mortality in pulmonary arterial hypertension. Chest. 147: 198-208. PMID 25211049 DOI: 10.1378/chest.13-3035  0.02
2010 Austin C. Editorial Comment Urology. 75: 169. PMID 20109716 DOI: 10.1016/j.urology.2009.07.1269  0.013
2021 Jones P, Rajasegaran A, Brassale S, Chen Y, Haslam R, Austin C, Seideman CA. Assessment of the Educational Value of Distal Hypospadias Repair Videos on YouTube. Urology. PMID 34461144 DOI: 10.1016/j.urology.2021.08.020  0.012
2020 Galson S, Austin CP, Khandekar E, Hudson LD, DiMasi JA, Califf R, Wagner JA. The failure to fail smartly. Nature Reviews. Drug Discovery. PMID 32968225 DOI: 10.1038/d41573-020-00167-0  0.01
1991 Austin CP, Lessell S. Horner's syndrome from hypothalamic infarction. Archives of Neurology. 48: 332-4. PMID 2001193  0.01
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