☰

Kai Chen - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
organic chemistry, organometallic chemistry, chemical biology
Tree Info Similar researchers PubMed Report error

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wackelin DJ, Mao R, Sicinski KM, Zhao Y, Das A, Chen K, Arnold FH. Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society. PMID 38166100 DOI: 10.1021/jacs.3c11722  0.741
2023 Gao J, He XC, Liu YL, Ye ZP, Guan JP, Chen K, Xiang HY, Yang H. Photoredox/Nickel Dual Catalysis-Enabled Cross-Dehydrogenative C-H Amination of Indoles with Unactivated Amine. Organic Letters. PMID 37842950 DOI: 10.1021/acs.orglett.3c03073  0.324
2023 Deng KY, Wang ZW, Xie ZZ, He JT, Guan JP, Chen K, Xiang HY, Yang H. Photocatalysed C-H amidation of indoles enabled by -butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate. Chemical Communications (Cambridge, England). PMID 37668188 DOI: 10.1039/d3cc03532h  0.352
2023 Calvó-Tusell C, Liu Z, Chen K, Arnold FH, Garcia-Borràs M. Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie (International Ed. in English). e202303879. PMID 37260412 DOI: 10.1002/anie.202303879  0.583
2023 Yuan CP, Zheng Y, Xie ZZ, Deng KY, Chen HB, Xiang HY, Chen K, Yang H. Photosensitized Vicinal Sulfonylamination of Alkenes with Oxime Ester and DABCO·(SO). Organic Letters. 25: 1782-1786. PMID 36884012 DOI: 10.1021/acs.orglett.3c00559  0.301
2022 Li W, Zhang H, Chen K, Jiang H, Sun J, Zhu S. Palladium-catalyzed intramolecular enantioselective C(sp)-H insertion of donor/donor carbenes. Chemical Science. 13: 12396-12402. PMID 36382271 DOI: 10.1039/d2sc03524c  0.305
2022 Kang QK, Li Y, Chen K, Zhu H, Wu WQ, Lin Y, Shi H. Corrigendum: Rhodium-Catalyzed Stereoselective Deuteration of Benzylic C-H Bonds via Reversible η -Coordination. Angewandte Chemie (International Ed. in English). 61: e202203820. PMID 35686879 DOI: 10.1002/anie.202203820  0.316
2021 Liu Z, Calvó-Tusell C, Zhou AZ, Chen K, Garcia-Borràs M, Arnold FH. Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation. Nature Chemistry. 13: 1166-1172. PMID 34663919 DOI: 10.1038/s41557-021-00794-z  0.582
2020 Chen K, Arnold FH. Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes. Journal of the American Chemical Society. PMID 32223130 DOI: 10.1021/Jacs.0C01313  0.575
2020 Zhou AZ, Chen K, Arnold FH. Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers Acs Catalysis. 10: 5393-5398. DOI: 10.1021/Acscatal.0C01349  0.556
2019 Brandenberg OF, Chen K, Arnold FH. Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society. PMID 31070908 DOI: 10.1021/Jacs.9B02931  0.612
2019 Chen K, Huang X, Zhang SQ, Zhou AZ, Kan SBJ, Hong X, Arnold FH. Engineered Cytochrome -Catalyzed Lactone-Carbene B-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 378-382. PMID 30930550 DOI: 10.1055/S-0037-1611662  0.58
2018 Chen K, Shi BF. Macrocyclic peptide construction through C-H activation strategy. Science Bulletin. 63: 1238-1240. PMID 36658859 DOI: 10.1016/j.scib.2018.09.008  0.457
2018 Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp C-H functionalization. Nature. PMID 30568304 DOI: 10.1038/S41586-018-0808-5  0.74
2018 Chen K, Zhang SQ, Brandenberg OF, Hong X, Arnold FH. Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions. Journal of the American Chemical Society. PMID 30372623 DOI: 10.1021/Jacs.8B09613  0.601
2018 Knight AM, Kan SBJ, Lewis RD, Brandenberg OF, Chen K, Arnold FH. Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes. Acs Central Science. 4: 372-377. PMID 29632883 DOI: 10.1021/Acscentsci.7B00548  0.576
2018 Chen K, Huang X, Kan SBJ, Zhang RK, Arnold FH. Enzymatic construction of highly strained carbocycles. Science (New York, N.Y.). 360: 71-75. PMID 29622650 DOI: 10.1126/Science.Aar4239  0.52
2018 Brandenberg OF, Prier CK, Chen K, Knight AM, Wu Z, Arnold FH. Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes Acs Catalysis. 8: 2629-2634. DOI: 10.1021/Acscatal.7B04423  0.578
2017 Kan SBJ, Huang X, Gumulya Y, Chen K, Arnold FH. Genetically programmed chiral organoborane synthesis. Nature. 552: 132-136. PMID 29186119 DOI: 10.1038/Nature24996  0.6
2017 Ling PX, Fang SL, Yin XS, Zhang Q, Chen K, Shi BF. Palladium-catalyzed sequential monoarylation/amidation of C(sp(3))-H bonds: stereoselective synthesis of α-amino-β-lactams and anti-α,β-diamino acid. Chemical Communications (Cambridge, England). PMID 28555232 DOI: 10.1039/C7Cc02426F  0.589
2017 Ling PX, Chen K, Shi BF. Palladium-catalyzed interannular meta-C-H arylation. Chemical Communications (Cambridge, England). PMID 28144666 DOI: 10.1039/C7Cc00110J  0.588
2016 Kan SB, Lewis RD, Chen K, Arnold FH. Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Science (New York, N.Y.). 354: 1048-1051. PMID 27885032 DOI: 10.1126/Science.Aah6219  0.573
2016 Liao G, Yin XS, Chen K, Zhang Q, Zhang SQ, Shi BF. Stereoselective alkoxycarbonylation of unactivated C(sp3)-H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis. Nature Communications. 7: 12901. PMID 27678161 DOI: 10.1038/Ncomms12901  0.548
2016 Liu YJ, Liu YH, Zhang ZZ, Yan SY, Chen K, Shi BF. Divergent and Stereoselective Synthesis of β-Silyl-α-Amino Acids through Palladium-Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C-H Bonds. Angewandte Chemie (International Ed. in English). PMID 27678130 DOI: 10.1002/Anie.201607766  0.593
2016 Chen K, Li X, Zhang S, Shi B. Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids Organic Chemistry Frontiers. 3: 204-208. DOI: 10.1039/C5Qo00319A  0.575
2015 Ling PX, Fang SL, Yin XS, Chen K, Sun BZ, Shi BF. Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 17503-7. PMID 26769628 DOI: 10.1002/Chem.201502621  0.556
2015 Chen K, Li X, Zhang SQ, Shi BF. Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp(3))-H alkylation of lactic acid. Chemical Communications (Cambridge, England). PMID 26679740 DOI: 10.1039/C5Cc07879B  0.596
2015 Rao WH, Zhan BB, Chen K, Ling PX, Zhang ZZ, Shi BF. Pd(II)-Catalyzed Direct Sulfonylation of Unactivated C(sp(3))-H Bonds with Sodium Sulfinates. Organic Letters. PMID 26110825 DOI: 10.1021/Acs.Orglett.5B01634  0.532
2015 Zhang Q, Yin XS, Chen K, Zhang SQ, Shi BF. Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp(3))-H Bonds: Scope and Mechanistic Studies. Journal of the American Chemical Society. 137: 8219-26. PMID 26067591 DOI: 10.1021/Jacs.5B03989  0.581
2015 Chen K, Zhang SQ, Jiang HZ, Xu JW, Shi BF. Practical synthesis of anti-β-hydroxy-α-amino acids by Pd(II) -catalyzed sequential C(sp(3) )-H functionalization. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 3264-70. PMID 25589007 DOI: 10.1002/Chem.201405942  0.553
2014 Chen K, Zhang SQ, Xu JW, Hu F, Shi BF. A general and practical palladium-catalyzed monoarylation of β-methyl C(sp³)-H of alanine. Chemical Communications (Cambridge, England). 50: 13924-7. PMID 25259442 DOI: 10.1039/C4Cc06652A  0.54
2014 Chen K, Shi BF. Sulfonamide-promoted palladium(II)-catalyzed alkylation of unactivated methylene C(sp3)-H bonds with alkyl iodides. Angewandte Chemie (International Ed. in English). 53: 11950-4. PMID 25213367 DOI: 10.1002/Anie.201407848  0.562
2014 Zhang Q, Chen K, Shi BF. Recent progress in the synthesis of functionalized β-lactams through transition-metal-catalyzed C(sp3)-H amidation Synlett. 25: 1941-1945. DOI: 10.1055/S-0033-1338645  0.534
2013 Zhang Q, Chen K, Rao W, Zhang Y, Chen FJ, Shi BF. Stereoselective synthesis of chiral α-amino-β-lactams through palladium(II)-catalyzed sequential monoarylation/amidation of C(sp(3) )-H bonds. Angewandte Chemie (International Ed. in English). 52: 13588-92. PMID 24174011 DOI: 10.1002/Anie.201306625  0.546
1993 Chen K, Arnold FH. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences of the United States of America. 90: 5618-22. PMID 8516309 DOI: 10.1073/Pnas.90.12.5618  0.498
1992 Economou C, Chen K, Arnold FH. Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E. Biotechnology and Bioengineering. 39: 658-62. PMID 18600995 DOI: 10.1002/Bit.260390610  0.469
1992 Martinez P, Van Dam ME, Robinson AC, Chen K, Arnold FH. Stabilization of substilisin E in organic solvents by site-directed mutagenesis. Biotechnology and Bioengineering. 39: 141-7. PMID 18600924 DOI: 10.1002/Bit.260390204  0.443
1991 Chen KQ, Arnold FH. Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media. Bio/Technology (Nature Publishing Company). 9: 1073-7. PMID 1367624 DOI: 10.1038/Nbt1191-1073  0.471
1991 Chen KQ, Robinson AC, Van Dam ME, Martinez P, Economou C, Arnold FH. Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress. 7: 125-9. PMID 1367168 DOI: 10.1021/Bp00008A007  0.455
Show low-probability matches.