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Kenneth A. Bradley - Publications

Affiliations: 
2002-2015 Microbiology, Immunology & Molecular Genetics University of California, Los Angeles, Los Angeles, CA 
 2015- Antibiotics Discovery Hoffmann-La Roche 
Area:
biological toxins
Website:
https://www.linkedin.com/in/ken-bradley-b23b09b4
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Hartmann S, Nusbaum DJ, Kim K, Alameh S, Ho CC, Cruz RL, Levitin A, Bradley KA, Martchenko M. The role of a small molecule in the modulation of cell death signal transduction pathways. Acs Infectious Diseases. PMID 30354048 DOI: 10.1021/Acsinfecdis.8B00231  0.479
2018 Hartmann S, Lopez Cruz R, Alameh S, Ho CC, Rabideau AE, Pentelute BL, Bradley KA, Martchenko M. Characterization of a novel piperidine-based inhibitor of cathepsin B-dependent bacterial toxins and viruses. Acs Infectious Diseases. PMID 29749721 DOI: 10.1021/Acsinfecdis.8B00053  0.475
2015 Dixon SD, Huynh MM, Tamilselvam B, Spiegelman LM, Son SB, Eshraghi A, Blanke SR, Bradley KA. Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins. Plos One. 10: e0143977. PMID 26618479 DOI: 10.1371/Journal.Pone.0143977  0.678
2015 Zilbermintz L, Leonardi W, Jeong SY, Sjodt M, McComb R, Ho CL, Retterer C, Gharaibeh D, Zamani R, Soloveva V, Bavari S, Levitin A, West J, Bradley KA, Clubb RT, et al. Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting. Scientific Reports. 5: 13476. PMID 26310922 DOI: 10.1038/Srep13476  0.392
2015 Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1. Plos One. 10: e0121833. PMID 25811598 DOI: 10.1371/Journal.Pone.0121833  0.318
2014 Rodgers MJ, Banks DJ, Bradley KA, Young JA. CHD1 and CHD2 are positive regulators of HIV-1 gene expression. Virology Journal. 11: 180. PMID 25297984 DOI: 10.1186/1743-422X-11-180  0.486
2014 Eshraghi A, Dixon SD, Tamilselvam B, Kim EJ, Gargi A, Kulik JC, Damoiseaux R, Blanke SR, Bradley KA. Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry. Plos Pathogens. 10: e1004295. PMID 25078082 DOI: 10.1371/Journal.Ppat.1004295  0.633
2014 Jung ME, Chamberlain BT, Ho CL, Gillespie EJ, Bradley KA. Structure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry. Acs Medicinal Chemistry Letters. 5: 363-7. PMID 24900841 DOI: 10.1021/Ml400486K  0.79
2014 Liu R, France B, George S, Rallo R, Zhang H, Xia T, Nel AE, Bradley K, Cohen Y. Association rule mining of cellular responses induced by metal and metal oxide nanoparticles. The Analyst. 139: 943-53. PMID 24260774 DOI: 10.1039/C3An01409F  0.309
2013 Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, ... ... Bradley KA, et al. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences of the United States of America. 110: E4904-12. PMID 24191014 DOI: 10.1073/Pnas.1302334110  0.793
2013 Gargi A, Tamilselvam B, Powers B, Prouty MG, Lincecum T, Eshraghi A, Maldonado-Arocho FJ, Wilson BA, Bradley KA, Blanke SR. Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi. The Journal of Biological Chemistry. 288: 7492-505. PMID 23306199 DOI: 10.1074/Jbc.M112.448118  0.797
2013 Papineni R, Ahmed I, LeVine S, Bradley K, Mclaughlin W, Pizzonia J, Umar S. Abstract 2864: Molecular imaging of early inflammatory response during hyperplasia and/or colitis in response to bacterial infection. Cancer Research. 73: 2864-2864. DOI: 10.1158/1538-7445.Am2013-2864  0.356
2012 Weigel KJ, Rues L, Doyle EJ, Buchheit CL, Wood JG, Gallagher RJ, Kelly LE, Radel JD, Bradley KA, LeVine SM. Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background. Plos One. 7: e40126. PMID 22792226 DOI: 10.1371/Journal.Pone.0040126  0.305
2012 Ivask A, Suarez E, Patel T, Boren D, Ji Z, Holden P, Telesca D, Damoiseaux R, Bradley KA, Godwin H. Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial. Environmental Science & Technology. 46: 2398-405. PMID 22148163 DOI: 10.1021/Es203087M  0.333
2011 Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Ho CL, Mehrabian M, Pan C, Lusis AJ, Davis RC, LeVine SM, Bradley KA. Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. Plos Pathogens. 7: e1002469. PMID 22241984 DOI: 10.1371/Journal.Ppat.1002469  0.735
2011 Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, et al. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Molecular Cancer Therapeutics. 10: 1818-28. PMID 21859839 DOI: 10.1158/1535-7163.Mct-11-0268  0.309
2011 Larabee JL, Maldonado-Arocho FJ, Pacheco S, France B, DeGiusti K, Shakir SM, Bradley KA, Ballard JD. Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages. Infection and Immunity. 79: 3302-8. PMID 21576335 DOI: 10.1128/Iai.05070-11  0.797
2011 Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, et al. Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells. Acs Nano. 5: 2756-69. PMID 21366263 DOI: 10.1021/Nn200328M  0.339
2010 Bradley KA, LeVine SM. Anthrax toxin delivers a one-two punch. Cell Host & Microbe. 8: 394-5. PMID 21075350 DOI: 10.1016/J.Chom.2010.10.011  0.364
2010 Ramey JD, Villareal VA, Ng C, Ward SC, Xiong JP, Clubb RT, Bradley KA. Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry. 49: 7403-10. PMID 20690680 DOI: 10.1021/Bi100887W  0.719
2010 Eshraghi A, Maldonado-Arocho FJ, Gargi A, Cardwell MM, Prouty MG, Blanke SR, Bradley KA. Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. The Journal of Biological Chemistry. 285: 18199-207. PMID 20385557 DOI: 10.1074/Jbc.M110.112912  0.799
2010 Terra JK, Cote CK, France B, Jenkins AL, Bozue JA, Welkos SL, LeVine SM, Bradley KA. Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. Journal of Immunology (Baltimore, Md. : 1950). 184: 17-20. PMID 19949100 DOI: 10.4049/Jimmunol.0903114  0.761
2009 Averette KM, Pratt MR, Yang Y, Bassilian S, Whitelegge JP, Loo JA, Muir TW, Bradley KA. Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. Plos One. 4: e7913. PMID 19924255 DOI: 10.1371/Journal.Pone.0007913  0.77
2009 Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W. Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infection and Immunity. 77: 4028-40. PMID 19581399 DOI: 10.1128/Iai.00232-09  0.786
2009 Maldonado-Arocho FJ, Bradley KA. Anthrax edema toxin induces maturation of dendritic cells and enhances chemotaxis towards macrophage inflammatory protein 3beta. Infection and Immunity. 77: 2036-42. PMID 19273556 DOI: 10.1128/Iai.01329-08  0.777
2009 Poulos JL, Jeon TJ, Damoiseaux R, Gillespie EJ, Bradley KA, Schmidt JJ. Ion channel and toxin measurement using a high throughput lipid membrane platform. Biosensors & Bioelectronics. 24: 1806-10. PMID 18849158 DOI: 10.1016/J.Bios.2008.08.041  0.743
2008 Cote CK, DiMezzo TL, Banks DJ, France B, Bradley KA, Welkos SL. Early interactions between fully virulent Bacillus anthracis and macrophages that influence the balance between spore clearance and development of a lethal infection. Microbes and Infection / Institut Pasteur. 10: 613-9. PMID 18467145 DOI: 10.1016/J.Micinf.2008.02.006  0.456
2007 Sanchez AM, Thomas D, Gillespie EJ, Damoiseaux R, Rogers J, Saxe JP, Huang J, Manchester M, Bradley KA. Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrobial Agents and Chemotherapy. 51: 2403-11. PMID 17485504 DOI: 10.1128/Aac.01184-06  0.789
2006 Salles II, Voth DE, Ward SC, Averette KM, Tweten RK, Bradley KA, Ballard JD. Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cellular Microbiology. 8: 1272-81. PMID 16882031 DOI: 10.1111/J.1462-5822.2006.00708.X  0.76
2006 Maldonado-Arocho FJ, Fulcher JA, Lee B, Bradley KA. Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells. Molecular Microbiology. 61: 324-37. PMID 16856939 DOI: 10.1111/J.1365-2958.2006.05232.X  0.814
2006 Ding Z, Bradley KA, Amin Arnaout M, Xiong JP. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expression and Purification. 49: 121-8. PMID 16798009 DOI: 10.1016/J.Pep.2006.04.011  0.371
2006 Wang W, Mulakala C, Ward SC, Jung G, Luong H, Pham D, Waring AJ, Kaznessis Y, Lu W, Bradley KA, Lehrer RI. Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. The Journal of Biological Chemistry. 281: 32755-64. PMID 16790431 DOI: 10.1074/Jbc.M603614200  0.412
2006 Banks DJ, Ward SC, Bradley KA. New insights into the functions of anthrax toxin. Expert Reviews in Molecular Medicine. 8: 1-18. PMID 16608555 DOI: 10.1017/S1462399406010714  0.448
2005 Bruce JW, Bradley KA, Ahlquist P, Young JA. Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication. Journal of Virology. 79: 12969-78. PMID 16188999 DOI: 10.1128/Jvi.79.20.12969-12978.2005  0.535
2005 Banks DJ, Barnajian M, Maldonado-Arocho FJ, Sanchez AM, Bradley KA. Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge. Cellular Microbiology. 7: 1173-85. PMID 16008584 DOI: 10.1111/J.1462-5822.2005.00545.X  0.812
2004 Sánchez AM, Bradley KA. Anthrax toxin: can a little be a good thing? Trends in Microbiology. 12: 143-5. PMID 15116717 DOI: 10.1016/J.Tim.2004.02.003  0.43
2003 Bradley KA, Mogridge J, Jonah G, Rainey A, Batty S, Young JA. Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions. The Journal of Biological Chemistry. 278: 49342-7. PMID 14507921 DOI: 10.1074/Jbc.M307900200  0.584
2003 Scobie HM, Rainey GJ, Bradley KA, Young JA. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proceedings of the National Academy of Sciences of the United States of America. 100: 5170-4. PMID 12700348 DOI: 10.1073/Pnas.0431098100  0.751
2003 Bradley KA, Young JA. Anthrax toxin receptor proteins. Biochemical Pharmacology. 65: 309-14. PMID 12527323 DOI: 10.1016/S0006-2952(02)01455-7  0.557
2001 Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA. Identification of the cellular receptor for anthrax toxin. Nature. 414: 225-9. PMID 11700562 DOI: 10.1038/N35101999  0.619
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