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Polo C. Lam, Ph.D. - Publications

Affiliations: 
2004 Virginia Polytechnic Institute and State University, Blacksburg, VA, United States 
Area:
Stereoselective synthesis, medicinal chemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J. Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae. Insect Science. PMID 28247978 DOI: 10.1111/1744-7917.12450  0.549
2016 Mutunga JM, Chen QH, Wong DM, Lam PC, Li J, Totrov MM, Gross AD, Carlier PR, Bloomquist JR. Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae. Chimia. 70: 704-708. PMID 27779928 DOI: 10.2533/Chimia.2016.704  0.652
2015 Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae. Bioorganic & Medicinal Chemistry. 23: 1321-40. PMID 25684426 DOI: 10.1016/J.Bmc.2015.01.026  0.717
2013 Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Pérez de León AA, Bloomquist JR. Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi. Pesticide Biochemistry and Physiology. 106. PMID 24187393 DOI: 10.1016/J.Pestbp.2013.03.005  0.641
2013 Mutunga JM, Boina DR, Anderson TD, Bloomquist JR, Carlier PR, Wong DM, Lam PC, Totrov MM. Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase. Archives of Insect Biochemistry and Physiology. 83: 180-94. PMID 23740645 DOI: 10.1002/Arch.21104  0.591
2013 Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR. Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae. Chemico-Biological Interactions. 203: 314-8. PMID 22989775 DOI: 10.1016/J.Cbi.2012.09.001  0.616
2012 Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, et al. Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron). Plos One. 7: e46712. PMID 23049714 DOI: 10.1371/Journal.Pone.0046712  0.691
2012 Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 22: 4593-8. PMID 22738634 DOI: 10.1016/J.Bmcl.2012.05.103  0.633
2011 Monceaux CJ, Hirata-Fukae C, Lam PC, Totrov MM, Matsuoka Y, Carlier PR. Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3992-6. PMID 21621412 DOI: 10.1016/J.Bmcl.2011.05.007  0.629
2009 Hsu DC, Lam PC, Slebodnick C, Carlier PR. Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones. Journal of the American Chemical Society. 131: 18168-76. PMID 19921816 DOI: 10.1021/Ja907507J  0.7
2008 Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC, Totrov MM, Bloomquist JR. Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae. Chemico-Biological Interactions. 175: 368-75. PMID 18554580 DOI: 10.1016/J.Cbi.2008.04.037  0.712
2005 Lam PC, Carlier PR. Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations. The Journal of Organic Chemistry. 70: 1530-8. PMID 15730270 DOI: 10.1021/Jo048450N  0.595
2003 Carlier PR, Zhao H, DeGuzman J, Lam PC. Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality. Journal of the American Chemical Society. 125: 11482-3. PMID 13129335 DOI: 10.1021/Ja0365781  0.61
2002 Carlier PR, Lam PC, Wong DM. Catalytic asymmetric synthesis of protected tryptophan regioisomers. The Journal of Organic Chemistry. 67: 6256-9. PMID 12182675 DOI: 10.1021/jo025964i  0.567
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