Richard Neubig - Publications

Affiliations: 
1980 pharmacolgy Harvard Medical School, Boston, MA, United States 

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Sjogren B, Parra S, Atkins KB, Karaj B, Neubig RR. DIGOXIN-MEDIATED UP-REGULATION OF RGS2 PROTEIN PROTECTS AGAINST CARDIAC INJURY. The Journal of Pharmacology and Experimental Therapeutics. PMID 26941169 DOI: 10.1124/jpet.115.231571  0.72
2016 Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R. RGS proteins and gαi2 modulate sleep, wakefulness, and disruption of sleep/ wake states after isoflurane and sevoflurane anesthesia Sleep. 39: 393-404. DOI: 10.5665/sleep.5450  0.72
2015 Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. 88: 762-773. PMID 26590347 DOI: 10.1016/j.neuron.2015.10.039  0.72
2015 Sumit M, Neubig RR, Takayama S, Linderman JJ. Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 1378-86. PMID 26374065 DOI: 10.1039/c5ib00181a  0.72
2015 Neubig RR. RGS-Insensitive G Proteins as In Vivo Probes of RGS Function. Progress in Molecular Biology and Translational Science. 133: 13-30. PMID 26123300 DOI: 10.1016/bs.pmbts.2015.04.010  0.72
2015 Sjögren B, Swaney S, Neubig RR. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Plos One. 10: e0123581. PMID 25970626 DOI: 10.1371/journal.pone.0123581  0.72
2015 Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. Acs Chemical Neuroscience. 6: 911-9. PMID 25844489 DOI: 10.1021/acschemneuro.5b00063  0.72
2015 Sisson TH, Ajayi IO, Subbotina N, Dodi AE, Rodansky ES, Chibucos LN, Kim KK, Keshamouni VG, White ES, Zhou Y, Higgins PD, Larsen SD, Neubig RR, Horowitz JC. Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis. The American Journal of Pathology. 185: 969-86. PMID 25681733 DOI: 10.1016/j.ajpath.2014.12.005  0.72
2014 Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. Journal of Molecular and Cellular Cardiology. 75: 152-61. PMID 25106095 DOI: 10.1016/j.yjmcc.2014.07.017  0.72
2014 Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Molecular Pharmacology. 86: 406-16. PMID 25086086 DOI: 10.1124/mol.114.092403  0.72
2014 Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacological Reviews. 66: 918-47. PMID 25026896 DOI: 10.1124/pr.114.008862  0.72
2014 Parra S, Huang X, Charbeneau RA, Wade SM, Kaur K, Rorabaugh BR, Neubig RR. Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury. Bmc Pharmacology & Toxicology. 15: 29. PMID 24899231 DOI: 10.1186/2050-6511-15-29  0.72
2014 Tsou PS, Haak AJ, Khanna D, Neubig RR. Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription. American Journal of Physiology. Cell Physiology. 307: C2-13. PMID 24740541 DOI: 10.1152/ajpcell.00060.2014  0.72
2014 Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. The Journal of Pharmacology and Experimental Therapeutics. 349: 480-6. PMID 24706986 DOI: 10.1124/jpet.114.213520  0.72
2014 Kehrl JM, Sahaya K, Dalton HM, Charbeneau RA, Kohut KT, Gilbert K, Pelz MC, Parent J, Neubig RR. Gain-of-function mutation in Gnao1: a murine model of epileptiform encephalopathy (EIEE17)? Mammalian Genome : Official Journal of the International Mammalian Genome Society. 25: 202-10. PMID 24700286 DOI: 10.1007/s00335-014-9509-z  0.72
2014 Lundquist MR, Storaska AJ, Liu TC, Larsen SD, Evans T, Neubig RR, Jaffrey SR. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 156: 563-76. PMID 24440334 DOI: 10.1016/j.cell.2013.12.035  0.72
2014 Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. The Journal of Biological Chemistry. 289: 1580-91. PMID 24297163 DOI: 10.1074/jbc.M113.528273  0.72
2014 Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflammatory Bowel Diseases. 20: 154-65. PMID 24280883 DOI: 10.1097/01.MIB.0000437615.98881.31  0.72
2013 Vashisth H, Storaska AJ, Neubig RR, Brooks CL. Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. Acs Chemical Biology. 8: 2778-84. PMID 24093330 DOI: 10.1021/cb400568g  0.72
2013 Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Cellular Signalling. 25: 2848-55. PMID 24041654 DOI: 10.1016/j.cellsig.2013.09.007  0.72
2013 Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway. Beilstein Journal of Organic Chemistry. 9: 966-73. PMID 23766813 DOI: 10.3762/bjoc.9.111  0.72
2013 Jovic A, Wade SM, Neubig RR, Linderman JJ, Takayama S. Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 932-9. PMID 23732791 DOI: 10.1039/c3ib40032h  0.72
2013 Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorganic & Medicinal Chemistry Letters. 23: 3826-32. PMID 23707258 DOI: 10.1016/j.bmcl.2013.04.080  0.72
2013 Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacological Reviews. 65: 967-86. PMID 23686350 DOI: 10.1124/pr.112.007179  0.72
2013 Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. The Journal of Biological Chemistry. 288: 17167-78. PMID 23629648 DOI: 10.1074/jbc.M113.464065  0.72
2013 Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4369-77. PMID 23467353 DOI: 10.1523/JNEUROSCI.5470-12.2013  0.72
2013 Storaska AJ, Neubig RR. NMR methods for detection of small molecule binding to RGS4. Methods in Enzymology. 522: 133-52. PMID 23374184 DOI: 10.1016/B978-0-12-407865-9.00008-X  0.72
2013 Lim WK, Kanelakis KC, Neubig RR. Regulation of G protein signaling by the 70kDa heat shock protein. Cellular Signalling. 25: 389-96. PMID 23153586 DOI: 10.1016/j.cellsig.2012.11.002  0.72
2012 Cho H, Kamenyeva O, Yung S, Gao JL, Hwang IY, Park C, Murphy PM, Neubig RR, Kehrl JH. The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites. Molecular and Cellular Biology. 32: 4561-71. PMID 22966200 DOI: 10.1128/MCB.00651-12  0.72
2012 Visovatti SH, Hyman MC, Bouis D, Neubig R, McLaughlin VV, Pinsky DJ. Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. Plos One. 7: e40829. PMID 22792409 DOI: 10.1371/journal.pone.0040829  0.72
2012 Jacob RT, Larsen MJ, Larsen SD, Kirchhoff PD, Sherman DH, Neubig RR. MScreen: an integrated compound management and high-throughput screening data storage and analysis system. Journal of Biomolecular Screening. 17: 1080-7. PMID 22706349 DOI: 10.1177/1087057112450186  0.72
2012 Sjögren B, Parra S, Heath LJ, Atkins KB, Xie ZJ, Neubig RR. Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels. Molecular Pharmacology. 82: 500-9. PMID 22695717 DOI: 10.1124/mol.112.079293  0.72
2012 Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein. Inflammation. 35: 1611-7. PMID 22581266 DOI: 10.1007/s10753-012-9476-z  0.72
2012 Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 443-53. PMID 22411356 DOI: 10.1007/s00210-011-0705-z  0.72
2012 Turner EM, Blazer LL, Neubig RR, Husbands SM. Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins. Acs Medicinal Chemistry Letters. 3: 146-150. PMID 22368763 DOI: 10.1021/ml200263y  0.72
2012 Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 119: 1935-45. PMID 22210881 DOI: 10.1182/blood-2011-10-387910  0.72
2011 Neubig RR. Major developments in our understanding of G protein-coupled receptors. Advances in Pharmacology (San Diego, Calif.). 62: xv-xvi. PMID 21907904 DOI: 10.1016/B978-0-12-385952-5.00012-9  0.72
2011 Kaur K, Kehrl JM, Charbeneau RA, Neubig RR. RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins. Methods in Molecular Biology (Clifton, N.J.). 756: 75-98. PMID 21870221 DOI: 10.1007/978-1-61779-160-4_4  0.72
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  0.72
2011 Jovic A, Wade SM, Miyawaki A, Neubig RR, Linderman JJ, Takayama S. Hi-Fi transmission of periodic signals amid cell-to-cell variability. Molecular Biosystems. 7: 2238-44. PMID 21559542 DOI: 10.1039/c1mb05031a  0.72
2011 Waterson RE, Thompson CG, Mabe NW, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR. Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart. Cardiovascular Research. 91: 45-52. PMID 21349876 DOI: 10.1093/cvr/cvr054  0.72
2011 Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 50: 3181-92. PMID 21329361 DOI: 10.1021/bi1019622  0.72
2011 Proudfoot J, Nosjean O, Blanchard J, Wang J, Besson D, Crankshaw D, Gauglitz G, Hertzberg R, Homon C, Llewellyn L, Neubig R, Walker L, Villa P. Glossary of terms used in biomolecular screening (IUPAC recommendations 2011) Pure and Applied Chemistry. 83: 1129-1158. DOI: 10.1351/PAC-REC-09-05-03  0.72
2010 Jovic A, Howell B, Cote M, Wade SM, Mehta K, Miyawaki A, Neubig RR, Linderman JJ, Takayama S. Phase-locked signals elucidate circuit architecture of an oscillatory pathway. Plos Computational Biology. 6: e1001040. PMID 21203481 DOI: 10.1371/journal.pcbi.1001040  0.72
2010 Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 116: 6092-100. PMID 20852125 DOI: 10.1182/blood-2010-05-283846  0.72
2010 Sjögren B, Blazer LL, Neubig RR. Regulators of G protein signaling proteins as targets for drug discovery. Progress in Molecular Biology and Translational Science. 91: 81-119. PMID 20691960 DOI: 10.1016/S1877-1173(10)91004-1  0.72
2010 Sjögren B, Neubig RR. Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Molecular Pharmacology. 78: 550-7. PMID 20664002 DOI: 10.1124/mol.110.065219  0.72
2010 Neubig RR. Mind your salts: when the inactive constituent isn't. Molecular Pharmacology. 78: 558-9. PMID 20651116 DOI: 10.1124/mol.110.067645  0.72
2010 Murai K, Qiu R, Zhang H, Wang J, Wu C, Neubig RR, Lu Q. Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells. Stem Cells (Dayton, Ohio). 28: 1581-9. PMID 20629171 DOI: 10.1002/stem.474  0.72
2010 Motulsky HJ, Neubig RR. Analyzing binding data. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 7.5. PMID 20578035 DOI: 10.1002/0471142301.ns0705s52  0.72
2010 Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology. 78: 524-33. PMID 20571077 DOI: 10.1124/mol.110.065128  0.72
2010 Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 107: 11086-91. PMID 20534514 DOI: 10.1073/pnas.1000003107  0.72
2010 Roman DL, Blazer LL, Monroy CA, Neubig RR. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Molecular Pharmacology. 78: 360-5. PMID 20530129 DOI: 10.1124/mol.109.063388  0.72
2010 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 26: 1804-5. PMID 20501551 DOI: 10.1093/bioinformatics/btq264  0.72
2010 Blazer LL, Roman DL, Muxlow MR, Neubig RR. Use of flow cytometric methods to quantify protein-protein interactions. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.11.1-15. PMID 20069525 DOI: 10.1002/0471142956.cy1311s51  0.72
2010 Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/j.1471-4159.2009.06519.x  0.72
2010 Evelyn CR, Bell JL, Ryu JG, Wade SM, Kocab A, Harzdorf NL, Showalter HD, Neubig RR, Larsen SD. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorganic & Medicinal Chemistry Letters. 20: 665-72. PMID 19963382 DOI: 10.1016/j.bmcl.2009.11.056  0.72
2009 Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R. Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. Anesthesia and Analgesia. 109: 1500-5. PMID 19843788 DOI: 10.1213/ANE.0b013e3181ba7815  0.72
2009 Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ. A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells. Cellular Signalling. 21: 1569-78. PMID 19560536 DOI: 10.1016/j.cellsig.2009.06.003  0.72
2009 Roman DL, Ota S, Neubig RR. Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors. Journal of Biomolecular Screening. 14: 610-9. PMID 19531661 DOI: 10.1177/1087057109336590  0.72
2009 Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9  0.72
2009 Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacological Reviews. 61: 1-8. PMID 19325074 DOI: 10.1124/pr.109.001107  0.72
2009 Huang X, Fu Y, Charbeneau RA, Neubig RR. GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. Medical Hypotheses. 73: 56-9. PMID 19282110 DOI: 10.1016/j.mehy.2009.01.040  0.72
2009 Peng W, Peltier DC, Larsen MJ, Kirchhoff PD, Larsen SD, Neubig RR, Miller DJ. Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses. The Journal of Infectious Diseases. 199: 950-7. PMID 19239364 DOI: 10.1086/597275  0.72
2009 Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Molecular Pharmacology. 75: 1222-30. PMID 19225179 DOI: 10.1124/mol.108.054296  0.72
2009 Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR. High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay. Journal of Biomolecular Screening. 14: 161-72. PMID 19196702 DOI: 10.1177/1087057108328761  0.72
2009 Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Molecular Pharmacology. 75: 514-24. PMID 19098122 DOI: 10.1124/mol.108.048744  0.72
2009 Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, ... ... Neubig RR, et al. IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Research. 37: D680-5. PMID 18948278 DOI: 10.1093/nar/gkn728  0.72
2009 Blazer LL, Neubig RR. Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 126-41. PMID 18800065 DOI: 10.1038/npp.2008.151  0.72
2008 Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/jbc.M805860200  0.72
2008 Bernsteel DJ, Roman DL, Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Analytical Biochemistry. 383: 180-5. PMID 18796290 DOI: 10.1016/j.ab.2008.08.026  0.72
2008 Neubig RR. And the winner is ... RGS4! Circulation Research. 103: 444-6. PMID 18757831 DOI: 10.1161/CIRCRESAHA.108.183384  0.72
2008 Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/j.1747-0285.2008.00687.x  0.72
2008 Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT. Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system. Analytical Chemistry. 80: 5225-31. PMID 18465881 DOI: 10.1021/ac800553g  0.72
2008 Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR. Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele. Diabetes. 57: 77-85. PMID 17928396 DOI: 10.2337/db07-0599  0.72
2007 Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science (New York, N.Y.). 318: 1923-7. PMID 18096806 DOI: 10.1126/science.1147554  0.72
2007 Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Van Rooijen N, Huber-Lang MS, Neubig RR, Ward PA. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature. 449: 721-5. PMID 17914358 DOI: 10.1038/nature06185  0.72
2007 Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Molecular Cancer Therapeutics. 6: 2249-60. PMID 17699722 DOI: 10.1158/1535-7163.MCT-06-0782  0.72
2007 Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. Bmc Bioinformatics. 8: 177. PMID 17537266 DOI: 10.1186/1471-2105-8-177  0.72
2007 Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara RK. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Combinatorial Chemistry & High Throughput Screening. 10: 289-98. PMID 17506713 DOI: 10.2174/138620707780636600  0.72
2007 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/pr.59.1.5  0.72
2007 Neubig RR. Missing links: mechanisms of protean agonism. Molecular Pharmacology. 71: 1200-2. PMID 17293557 DOI: 10.1124/mol.107.034926  0.72
2007 Fu Y, Huang X, Piao L, Lopatin AN, Neubig RR. Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2532-9. PMID 17277016 DOI: 10.1152/ajpheart.01391.2006  0.72
2007 Jameson EE, Pei J, Wade SM, Neubig RR, Milligan G, Kennedy RT. Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity. Analytical Chemistry. 79: 1158-63. PMID 17263349 DOI: 10.1021/ac061099g  0.72
2007 Bodenstein J, Sunahara RK, Neubig RR. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Molecular Pharmacology. 71: 1040-50. PMID 17220356 DOI: 10.1124/mol.106.029397  0.72
2007 Rovati GE, Capra V, Neubig RR. The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Molecular Pharmacology. 71: 959-64. PMID 17192495 DOI: 10.1124/mol.106.029470  0.72
2007 Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara RK, Perkins NC, Steel DG, Swanson JA. Under the microscope: single molecule symposium at the University of Michigan, 2006. Biopolymers. 85: 106-14. PMID 17080420 DOI: 10.1002/bip.20621  0.72
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/mol.106.028670  0.72
2006 Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR. Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Molecular and Cellular Biology. 26: 6870-9. PMID 16943428 DOI: 10.1128/MCB.00314-06  0.72
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/j.1747-0285.2006.00373.x  0.72
2006 Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circulation Research. 98: 659-66. PMID 16456099 DOI: 10.1161/01.RES.0000207497.50477.60  0.72
2006 Myung CS, Lim WK, DeFilippo JM, Yasuda H, Neubig RR, Garrison JC. Regions in the G protein gamma subunit important for interaction with receptors and effectors. Molecular Pharmacology. 69: 877-87. PMID 16319284 DOI: 10.1124/mol.105.018994  0.72
2005 Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacological Reviews. 57: 541-6. PMID 16382107 DOI: 10.1124/pr.57.4.1  0.72
2005 Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacological Reviews. 57: 279-88. PMID 15914470 DOI: 10.1124/pr.57.2.5  0.72
2005 Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ. Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. The Journal of Biological Chemistry. 280: 22564-71. PMID 15767248 DOI: 10.1074/jbc.M414589200  0.72
2005 Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry. 44: 3418-31. PMID 15736952 DOI: 10.1021/bi0478704  0.72
2005 Traynor JR, Neubig RR. Regulators of G protein signaling & drugs of abuse. Molecular Interventions. 5: 30-41. PMID 15734717 DOI: 10.1124/mi.5.1.7  0.72
2005 Jameson EE, Roof RA, Whorton MH, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues Journal of Biological Chemistry. 280: 7712-7719. PMID 15613467 DOI: 10.1074/jbc.M413810200  0.72
2004 Whelan RJ, Sunahara RK, Neubig RR, Kennedy RT. Affinity assays using fluorescence anisotropy with capillary electrophoresis separation. Analytical Chemistry. 76: 7380-6. PMID 15595883 DOI: 10.1021/ac0489566  0.72
2004 Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity. Methods in Enzymology. 389: 266-77. PMID 15313571 DOI: 10.1016/S0076-6879(04)89016-5  0.72
2004 Wang Q, Liu M, Kozasa T, Rothestein JD, Sternweis PC, Neubig RR. Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins. Methods in Enzymology. 389: 244-65. PMID 15313570 DOI: 10.1016/S0076-6879(04)89015-3  0.72
2004 Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR. RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins. Methods in Enzymology. 389: 229-43. PMID 15313569 DOI: 10.1016/S0076-6879(04)89014-1  0.72
2004 Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR. Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. The Journal of Biological Chemistry. 279: 28831-4. PMID 15143072 DOI: 10.1074/jbc.C400105200  0.72
2004 Clark MJ, Neubig RR, Traynor JR. Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization. The Journal of Pharmacology and Experimental Therapeutics. 310: 215-22. PMID 15014136 DOI: 10.1124/jpet.103.064824  0.72
2004 Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors Journal of Peptide Research. 63: 141-146. PMID 15009535 DOI: 10.1111/j.1399-3011.2003.00114.x  0.72
2004 Simons PC, Biggs SM, Waller A, Foutz T, Cimino DF, Guo Q, Neubig RR, Tang WJ, Prossnitz ER, Sklar LA. Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. The Journal of Biological Chemistry. 279: 13514-21. PMID 14726530 DOI: 10.1074/jbc.M310306200  0.72
2003 Soyer OS, Dimmic MW, Neubig RR, Goldstein RA. Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution. Biochemistry. 42: 14522-31. PMID 14661965 DOI: 10.1021/bi035097r  0.72
2003 Neubig RR, Spedding M, Kenakin T, Christopoulos A. International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology Pharmacological Reviews. 55: 597-606. PMID 14657418 DOI: 10.1124/pr.55.4.4  0.72
2003 Jameson EE, Cunliffe JM, Neubig RR, Sunahara RK, Kennedy RT. Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue Analytical Chemistry. 75: 4297-4304. PMID 14632149 DOI: 10.1021/ac0342976  0.72
2003 Qian B, Soyer OS, Neubig RR, Goldstein RA. Depicting a protein's two faces: GPCR classification by phylogenetic tree-based HMMs. Febs Letters. 554: 95-9. PMID 14596921 DOI: 10.1016/S0014-5793(03)01112-8  0.72
2003 Simons PC, Shi M, Foutz T, Cimino DF, Lewis J, Buranda T, Lim WK, Neubig RR, McIntire WE, Garrison J, Prossnitz E, Sklar LA. Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry. Molecular Pharmacology. 64: 1227-38. PMID 14573773 DOI: 10.1124/mol.64.5.1227  0.72
2003 Shangguan Y, Hall KE, Neubig RR, Wiley JW. Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha. Journal of Neurochemistry. 86: 1006-14. PMID 12887697 DOI: 10.1046/j.1471-4159.2003.01912.x  0.72
2003 Chai BX, Neubig RR, Millhauser GL, Thompson DA, Jackson PJ, Barsh GS, Dickinson CJ, Li JY, Lai YM, Gantz I. Inverse agonist activity of agouti and agouti-related protein. Peptides. 24: 603-9. PMID 12860205 DOI: 10.1016/S0196-9781(03)00104-9  0.72
2003 Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. The Journal of Biological Chemistry. 278: 19634-41. PMID 12649269 DOI: 10.1074/jbc.M300052200  0.72
2003 Clark MJ, Harrison C, Zhong H, Neubig RR, Traynor JR. Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways. The Journal of Biological Chemistry. 278: 9418-25. PMID 12524446 DOI: 10.1074/jbc.M208885200  0.72
2003 Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR. A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. The Journal of Biological Chemistry. 278: 7278-84. PMID 12446706 DOI: 10.1074/jbc.M208819200  0.72
2002 Motulsky H, Neubig R. Analyzing radioligand binding data. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 7.5. PMID 18428565 DOI: 10.1002/0471142301.ns0705s19  0.72
2002 Neubig RR. Regulators of G protein signaling (RGS proteins): Novel central nervous system drug targets Journal of Peptide Research. 60: 312-316. PMID 12464108 DOI: 10.1034/j.1399-3011.2002.21064.x  0.72
2002 Yoo JH, Yang YS, Choi I, Shangguan Y, Song I, Neubig RR, Wiley JW. Expression of novel splice variants of the G protein subunit, Go alpha, is tissue-specific and age-dependent in the rat. Gene. 296: 249-55. PMID 12383522 DOI: 10.1016/S0378-1119(02)00866-1  0.72
2002 Sarvazyan NA, Lim WK, Neubig RR. Fluorescence analysis of receptor-G protein interactions in cell membranes Biochemistry. 41: 12858-12867. PMID 12379129 DOI: 10.1021/bi026212l  0.72
2002 Neubig RR, Siderovski DP. Regulators of G-protein signalling as new central nervous system drug targets Nature Reviews Drug Discovery. 1: 187-197. PMID 12120503  0.72
2002 Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR. Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochemical and Biophysical Research Communications. 293: 1233-41. PMID 12054508 DOI: 10.1016/S0006-291X(02)00357-1  0.72
2002 Wang Q, Liu M, Mullah B, Siderovski DP, Neubig RR. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells Journal of Biological Chemistry. 277: 24949-24958. PMID 12006602 DOI: 10.1074/jbc.M203802200  0.72
2002 Soyer O, Dimmic MW, Neubig RR, Goldstein RA. Using evolutionary methods to study G-protein coupled receptors. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 625-36. PMID 11928514  0.72
2002 Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR. NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. Biochemistry. 41: 3596-604. PMID 11888275 DOI: 10.1021/bi015811+  0.72
2002 Seta K, Nanamori M, Gregory Modrall J, Neubig RR, Sadoshima J. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs Journal of Biological Chemistry. 277: 9268-9277. PMID 11777928 DOI: 10.1074/jbc.M109221200  0.72
2002 McEwen DP, Gee KR, Kang HC, Neubig RR. Fluorescence approaches to study G protein mechanisms. Methods in Enzymology. 344: 403-20. PMID 11771399 DOI: 10.1016/S0076-6879(02)44730-1  0.72
2001 Motulsky H, Neubig R. Analyzing radioligand binding data. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Appendix 3H. PMID 18429075 DOI: 10.1002/0471140864.psa03hs21  0.72
2001 Lim WK, Myung CS, Garrison JC, Neubig RR. Receptor - G protein γ specificity: γ 11 shows unique potency for A1 adenosine and 5-HT1A receptors Biochemistry. 40: 10532-10541. PMID 11523995 DOI: 10.1021/bi010950c  0.72
2001 Modrall JG, Nanamori M, Sadoshima J, Barnhart DC, Stanley JC, Neubig RR. ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling. American Journal of Physiology. Cell Physiology. 281: C801-9. PMID 11502557  0.72
2001 Zhong H, Neubig RR. Regulator of G protein signaling proteins: Novel multifunctional drug targets Journal of Pharmacology and Experimental Therapeutics. 297: 837-845. PMID 11356902  0.72
2001 Bennett TA, Key TA, Gurevich VV, Neubig R, Prossnitz ER, Sklar LA. Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system. The Journal of Biological Chemistry. 276: 22453-60. PMID 11309376 DOI: 10.1074/jbc.M009679200  0.72
2001 McEwen DP, Gee KR, Kang HC, Neubig RR. Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins. Analytical Biochemistry. 291: 109-17. PMID 11262163 DOI: 10.1006/abio.2001.5011  0.72
2001 Wade SM, Lan KL, Moore DJ, Neubig RR. Inverse agonist activity at the α2A-adrenergic receptor Molecular Pharmacology. 59: 532-542. PMID 11179449  0.72
2001 Lim WK, Neubig RR. Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) α and βγ subunits by urea Biochemical Journal. 354: 337-344. PMID 11171112 DOI: 10.1042/0264-6021:3540337  0.72
2001 Lapinski PE, Neubig RR, Raghavan M. Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding. The Journal of Biological Chemistry. 276: 7526-33. PMID 11099504 DOI: 10.1074/jbc.M009448200  0.72
2001 Park IK, Klug CA, Li K, Jerabek L, Lii L, Nanamori M, Neubig RR, Hoodi L, Weissman IL, Clarke MF. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells Journal of Biological Chemistry. 276: 915-923. PMID 11042171 DOI: 10.1074/jbc.M005947200  0.72
2000 Shea LD, Neubig RR, Linderman JJ. Timing is everything the role of kinetics in G protein activation. Life Sciences. 68: 647-58. PMID 11205879 DOI: 10.1016/S0024-3205(00)00977-2  0.72
2000 Lan KL, Zhong H, Nanamori M, Neubig RR. Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Gα(i) and Gα(o) deactivation: Gα specificity of RGS4 and RGS7 Journal of Biological Chemistry. 275: 33497-33503. PMID 10942773 DOI: 10.1074/jbc.M005785200  0.72
2000 Stanasila L, Lim WK, Neubig RR, Pattus F. Coupling efficacy and selectivity of the human μ-opioid receptor expressed as receptor-Gα fusion proteins in Escherichia coli Journal of Neurochemistry. 75: 1190-1199. PMID 10936202 DOI: 10.1046/j.1471-4159.2000.0751190.x  0.72
2000 Brink CB, Wade SM, Neubig RR. Agonist-directed trafficking of porcine α(2A)-adrenergic receptor signaling in chinese hamster ovary cells: I-isoproterenol selectively activates G(s) Journal of Pharmacology and Experimental Therapeutics. 294: 539-547. PMID 10900230  0.72
2000 Sullivan SM, Mishra R, Neubig RR, Maddock JR. Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era Journal of Bacteriology. 182: 3460-3466. PMID 10852878 DOI: 10.1128/JB.182.12.3460-3466.2000  0.72
1999 Popa-Wagner A, Fischer B, Platt D, Neubig R, Schmoll H, Kessler C. Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole Neuroscience. 94: 395-403. PMID 10579203 DOI: 10.1016/S0306-4522(99)00204-3  0.72
1999 Wade SM, Lim WK, Lan KL, Chung DA, Nanamori M, Neubig RR. G(i) activator region of {2A)-adrenergic receptors: Distinct basic residues mediate G(i) versus G(s) activation Molecular Pharmacology. 56: 1005-1013. PMID 10531407  0.72
1999 Remmers AE, Engel C, Liu M, Neubig RR. Interdomain interactions regulate GDP release from heterotrimeric G proteins Biochemistry. 38: 13795-13800. PMID 10529224 DOI: 10.1021/bi990887f  0.72
1998 Lan KL, Sarvazyan NA, Taussig R, Mackenzie RG, DiBello PR, Dohlman HG, Neubig RR. A point mutation in Gα(o) and Gα(i1) blocks interaction with regulator of G protein signaling proteins Journal of Biological Chemistry. 273: 12794-12797. PMID 9582306 DOI: 10.1074/jbc.273.21.12794  0.72
1998 Thompson JB, Wade SM, Harrison JK, Salafranca MN, Neubig RR. Cotransfection of second and third intracellular loop fragments inhibit angiotensin AT1a receptor activation of phospholipase C in HEK-293 cells. The Journal of Pharmacology and Experimental Therapeutics. 285: 216-22. PMID 9536013  0.72
1998 Sarvazyan NA, Remmers AE, Neubig RR. Determinants of G(i1)α and βγ binding. Measuring high affinity interactions in a lipid environment using flow cytometry Journal of Biological Chemistry. 273: 7934-7940. PMID 9525890 DOI: 10.1074/jbc.273.14.7934  0.72
1998 Lan KL, Remmers AE, Neubig RR. Roles of G(oα) tryptophans in GTP hydrolysis, GDP release, and fluorescence signals Biochemistry. 37: 837-843. PMID 9454573 DOI: 10.1021/bi972122i  0.72
1998 Sarvazyan NA, Neubig RR. Analysis of molecular assemblies by flow cytometry: Determinants of Gi1 α and βγ binding Proceedings of Spie - the International Society For Optical Engineering. 3256: 122-131. DOI: 10.1117/12.307055  0.72
1998 Neubig RR. Specificity of receptor-G protein coupling: Protein structure and cellular determinants Seminars in Neuroscience. 9: 189-197. DOI: 10.1006/smns.1997.0117  0.72
1997 Zhu M, Neubig RR, Wade SM, Posner P, Gelband CH, Sumners C. Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide American Journal of Physiology - Cell Physiology. 273: C1040-C1048. PMID 9316425  0.72
1997 Taylor P, Ross EM, Sternweis PC, Neubig RR, McCammon JA. Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997). Molecular Pharmacology. 52: 1-5. PMID 9224805  0.72
1997 Diversé-Pierluissi M, Remmers AE, Neubig RR, Dunlap K. Novel form of crosstalk between G protein and tyrosine kinase pathways. Proceedings of the National Academy of Sciences of the United States of America. 94: 5417-21. PMID 9144252 DOI: 10.1073/pnas.94.10.5417  0.72
1997 Zhu M, Neubig RR, Wade SM, Posner P, Gelband CH, Sumners C. Modulati on of K+ and Ca2+ currents in cultured neurons by an angiotensin II type la receptor peptide American Journal of Physiology. 273: C988-C998.  0.72
1996 Graham RM, Neubig R, Lynch KR. alpha 2-Adrenoceptors take centre stage at Nashville meeting. Trends in Pharmacological Sciences. 17: 90-4. PMID 8936342 DOI: 10.1016/0165-6147(96)30004-7  0.72
1996 Wade SM, Scribner MK, Dalman HM, Taylor JM, Neubig RR. Structural requirements for G(o) activation by receptor-derived peptides: Activation and modulation domains of the α2-adrenergic receptor i3c region Molecular Pharmacology. 50: 351-358. PMID 8700143  0.72
1996 Taylor JM, Jacob-Mosier GG, Lawton RG, VanDort M, Neubig RR. Receptor and membrane interaction sites on Gbeta. A receptor-derived peptide binds to the carboxyl terminus. The Journal of Biological Chemistry. 271: 3336-9. PMID 8631928  0.72
1996 Remmers AE, Neubig RR. Partial G protein activation by fluorescent guanine nucleotide analogs: Evidence for a triphosphate-bound but inactive state Journal of Biological Chemistry. 271: 4791-4797. PMID 8617747  0.72
1995 Kjeldsen SE, Weder AB, Egan B, Neubig R, Zweifler AJ, Julius S. Effect of circulating epinephrine on platelet function and hematocrit Hypertension. 25: 1096-1105. PMID 7737722  0.72
1995 Marin EP, Neubig RR. Lack of association of G-protein β2- and γ2-subunit N-terminal fragments provides evidence against the coiled-coil model of subunit-βγ assembly Biochemical Journal. 309: 377-380. PMID 7625998  0.72
1995 Uhlen S, Axelrod D, Keefer JR, Limbird LE, Neubig RR. Membrane organization and mobility of α2 adrenergic receptors in MDCK cells Pharmacology Communications. 6: 155-167.  0.72
1994 Remmers AE, Posner R, Neubig RR. Fluorescent guanine nucleotide analogs and G protein activation Journal of Biological Chemistry. 269: 13771-13778. PMID 8188654  0.72
1994 Neubig RR. Membrane organization in G-protein mechanisms Faseb Journal. 8: 939-946. PMID 8088459  0.72
1994 Wade SM, Dalman HM, Yang SZ, Neubig RR. Multisite interactions of receptors and G proteins: Enhanced potency of dimeric receptor peptides in modifying G protein function Molecular Pharmacology. 45: 1191-1197. PMID 8022412  0.72
1994 Uhlen S, Porter AC, Neubig RR. The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors Journal of Pharmacology and Experimental Therapeutics. 271: 1558-1565. PMID 7996470  0.72
1994 Taylor JM, Jacob-Mosier GG, Lawton RG, Neubig RR. Coupling an alpha 2-adrenergic receptor peptide to G-protein: a new photolabeling agent. Peptides. 15: 829-34. PMID 7984502 DOI: 10.1016/0196-9781(94)90038-8  0.72
1994 Taylor JM, Jacob-Mosier GG, Lawton RG, Remmers AE, Neubig RR. Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha. The Journal of Biological Chemistry. 269: 27618-24. PMID 7961678  0.72
1994 Kwon G, Axelrod D, Neubig RR. Lateral mobility of tetramethylrhodamine (TMR) labelled G protein α and βγ subunits in NG 108-15 cells Cellular Signalling. 6: 663-679. PMID 7857770 DOI: 10.1016/0898-6568(94)90049-3  0.72
1994 Taylor JM, Neubig RR. Peptides as probes for G protein signal transduction Cellular Signalling. 6: 841-849. PMID 7718404 DOI: 10.1016/0898-6568(94)90017-5  0.72
1994 Neubig RR, Connolly MP, Remmers AE. Rapid kinetics of G protein subunit association: A rate-limiting conformational change? Febs Letters. 355: 251-253. PMID 7527348 DOI: 10.1016/0014-5793(94)01212-1  0.72
1993 Neubig RR, Sklar LA. Subsecond modulation of formyl peptide-linked guanine nucleotide-binding proteins by guanosine 5′-O-(3-thio)triphosphate in permeabilized neutrophils Molecular Pharmacology. 43: 734-740. PMID 8502230  0.72
1993 Neubig RR. Synthesis and characterization of fluorescently labeled bovine brain G protein subunits Biochemistry. 32: 2401-2408. PMID 8443180  0.72
1993 Graeser D, Neubig RR. Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: Lack of cross-talk in agonist binding among the α2-adrenergic, muscarinic, and opiate receptors Molecular Pharmacology. 43: 434-443. PMID 8095695  0.72
1993 Zuiderweg ERP, van Doren SR, Kurochkin AV, Neubig RR, Majumdar A. Modern NMR spectroscopy of proteins and peptides in solution and its relevance to drug design Perspectives in Drug Discovery and Design. 1: 391-417. DOI: 10.1007/BF02174537  0.72
1992 Mangels LA, Neubig RR, Hamm HE, Gnegy ME. Calmodulin binding distinguishes between βγ subunits of activated G proteins and transducin Biochemical Journal. 283: 683-690. PMID 1590758  0.72
1992 Omann GM, Harter JM, Hassan N, Mansfield PJ, Suchard SJ, Neubig RR. A threshold level of coupled G-proteins is required to transduce neutrophil responses. Journal of Immunology (Baltimore, Md. : 1950). 149: 2172-8. PMID 1517577  0.72
1991 Gerhardt MA, Neubig RR. Multiple Gi protein subtypes regulate a single effector mechanism Molecular Pharmacology. 40: 707-711. PMID 1658606  0.72
1991 Dalman HM, Neubig RR. Two peptides from the α2a-adrenergic receptor alter receptor G protein coupling by distinct mechanisms Journal of Biological Chemistry. 266: 11025-11029. PMID 1645720  0.72
1990 Sekkarie MA, Egan BM, Neubig RR, Supiano MA. Sensitization of human α1- and α2-adrenergic venous responses by guanadrel sulfate Clinical Pharmacology and Therapeutics. 48: 537-543. PMID 2171846  0.72
1990 Zamorski MA, Ferraro JC, Neubig RR. Subcellular distribution of α2-adrenergic receptors, pertussis-toxin substrate and adenylate cyclase in human platelets Biochemical Journal. 265: 755-762. PMID 2154968  0.72
1990 Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors. Molecular Pharmacology. 37: 65-8. PMID 2153910  0.72
1990 Gerhardt MA, Wade SM, Neubig RR. p-[125I]iodoclonidine is a partial agonist at the α2-adrenergic receptor Molecular Pharmacology. 38: 214-221. PMID 1974694  0.72
1990 Graeser CA, Neubig RR. Cross-talk: Effects of agonist binding and receptor/G-protein coupling European Journal of Pharmacology. 183: 2154. DOI: 10.1016/0014-2999(90)93678-J  0.72
1989 Kjeldsen SE, Neubig RR, Weder AB, Zweifler AJ. The hypertension-coronary heart disease dilemma: The catecholamine-blood platelet connection Journal of Hypertension. 7: 851-860. PMID 2691575  0.72
1989 Neubig RR, Thomsen WJ. How does a key fit a flexible lock? Structure and dynamics in receptor function Bioessays. 11: 136-141. PMID 2686629  0.72
1989 Thomsen WJ, Neubig RR. Rapid Kinetics of α2-Adrenergic Inhibition of Adenylate Cyclase. Evidence for a Distal Rate-Limiting Step Biochemistry. 28: 8778-8786. PMID 2574993  0.72
1989 Supiano MA, Neubig RR, Linares OA, Halter JB, Rosen SG. Effects of low-sodium diet on regulation of platelet α2-adrenergic receptors in young and elderly humans American Journal of Physiology - Endocrinology and Metabolism. 256: 19/3. PMID 2538069  0.72
1988 Thomsen WJ, Jacquez JA, Neubig RR. Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor. Molecular Pharmacology. 34: 814-22. PMID 2904647  0.72
1988 Gantzos RD, Neubig RR. Temperature effects on α2-adrenergic receptor-Gi interactions Biochemical Pharmacology. 37: 2815-2821. PMID 2840078 DOI: 10.1016/0006-2952(88)90045-7  0.72
1988 Neubig RR, Gantzos RD, Thomson WJ. Mechanism of Agonist and Antagonist Binding to α2 Adrenergic Receptors: Evidence for a Precoupled Receptor-Guanine Nucleotide Protein Complex Biochemistry®. 27: 2374-2384. PMID 2838071  0.72
1987 Van Dort M, Neubig R, Counsell RE. Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor. Journal of Medicinal Chemistry. 30: 1241-4. PMID 3037080  0.72
1987 Kim MH, Neubig RR. Membrane reconstitution of high-affinity α2 adrenergic agonist binding with guanine nucleotide regulatory proteins Biochemistry. 26: 3664-3672. PMID 2888480  0.72
1986 Bittner MA, Holz RW, Neubig RR. Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells. The Journal of Biological Chemistry. 261: 10182-8. PMID 3015921  0.72
1986 Neubig RR, Szamraj O. Large-scale purification of α2-adrenergic receptor-enriched membranes from human platelets. Persistent association of guanine nucleotides with nonpurified membranes Bba - Biomembranes. 854: 67-76. PMID 3002464 DOI: 10.1016/0005-2736(86)90065-9  0.72
1985 Kim MH, Neubig RR. Parallel inactivation of α2-adrenergic agonist binding and Ni by alkaline treatment Febs Letters. 192: 321-325. PMID 2998875 DOI: 10.1016/0014-5793(85)80134-4  0.72
1985 Egan B, Neubig R, Julius S. Pharmacologic reduction of sympathetic drive increases platelet alpha-2-receptor number Clinical Pharmacology and Therapeutics. 38: 519-524. PMID 2996819  0.72
1985 Neubig RR, Gantzos RD, Brasier RS. Agonist and antagonist binding to α2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry Molecular Pharmacology. 28: 475-486. PMID 2865672  0.72
1985 Egan B, Neubig R, Schneider RH, Julius S. Methods for measuring vascular and nonvascular α-receptor sensitivity in humans Journal of Cardiovascular Pharmacology. 7: S153-S158. PMID 2414579  0.72
1982 Neubig RR, Boyd ND, Cohen JB. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry. 21: 3460-7. PMID 7115680  0.72
1981 Froehner SC, Gulbrandsen V, Hyman C, Jeng AY, Neubig RR, Cohen JB. Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes. Proceedings of the National Academy of Sciences of the United States of America. 78: 5230-4. PMID 7029531  0.72
1980 Neubig RR, Cohen JB. Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times. Biochemistry. 19: 2770-9. PMID 7397104  0.92
1979 Neubig RR, Cohen JB. Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions. Biochemistry. 18: 5464-75. PMID 518850  0.92
1979 Neubig RR, Krodel EK, Boyd ND, Cohen JB. Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides. Proceedings of the National Academy of Sciences of the United States of America. 76: 690-4. PMID 34154  0.72
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