Lennart Mucke - Publications

Gladstone Institute/UCSF, San Francisco, CA, United States 
 University of California, San Francisco, San Francisco, CA 
Neurobiology of Diseases Affecting Cognitive Functions

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Year Citation  Score
2020 Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Molecular Neurodegeneration. 15: 53. PMID 32921309 DOI: 10.1186/s13024-020-00393-5  1
2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, ... ... Mucke L, et al. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Science Translational Medicine. 12. PMID 32848093 DOI: 10.1126/scitranslmed.aaz5677  1
2020 Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, Guo W, Mucke L. Tau Reduction Prevents Key Features of Autism in Mouse Models. Neuron. PMID 32126198 DOI: 10.1016/j.neuron.2020.01.038  0.64
2019 Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathologica Communications. 7: 77. PMID 31101070 DOI: 10.1186/s40478-019-0723-5  0.6
2018 Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L. Klotho controls the brain-immune system interface in the choroid plexus. Proceedings of the National Academy of Sciences of the United States of America. PMID 30413620 DOI: 10.1073/pnas.1808609115  0.64
2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, ... ... Mucke L, et al. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 174: 505-520. PMID 30053424 DOI: 10.1016/j.cell.2018.06.016  1
2018 Das M, Maeda S, Hu B, Yu GQ, Guo W, Lopez I, Yu X, Tai C, Wang X, Mucke L. Neuronal levels and sequence of tau modulate the power of brain rhythms. Neurobiology of Disease. PMID 29859869 DOI: 10.1016/j.nbd.2018.05.020  0.64
2018 Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. PMID 29551491 DOI: 10.1016/j.neuron.2018.02.029  1
2017 Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiology of Disease. PMID 29100987 DOI: 10.1016/j.nbd.2017.10.014  0.64
2016 Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nature Reviews. Neuroscience. PMID 27829687 DOI: 10.1038/nrn.2016.141  1
2016 Maeda S, Mucke L. Tau Phosphorylation-Much More than a Biomarker. Neuron. 92: 265-267. PMID 27764656 DOI: 10.1016/j.neuron.2016.10.011  0.4
2016 Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, ... ... Mucke L, et al. Incidence and Impact of Subclinical Epileptiform Activity in Alzheimer's Disease. Annals of Neurology. PMID 27696483 DOI: 10.1002/ana.24794  0.76
2016 Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. Embo Reports. PMID 26931567 DOI: 10.15252/embr.201541438  1
2015 Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Annals of Clinical and Translational Neurology. 2: 1012-28. PMID 26732627 DOI: 10.1002/acn3.257  0.64
2015 Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nature Communications. 6: 8897. PMID 26615780 DOI: 10.1038/ncomms9897  1
2015 Miyamoto T, Kim D, Knox JA, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell-Surface Glutamate Receptors by a Mechanism that Requires EphB2's PDZ-binding Motif and Neuronal Activity. The Journal of Biological Chemistry. PMID 26589795 DOI: 10.1074/jbc.M115.666529  1
2015 Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nature Neuroscience. 18: 1183-9. PMID 26192747 DOI: 10.1038/nn.4067  0.4
2015 Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of Cell Biology. 209: 419-33. PMID 25963821 DOI: 10.1083/jcb.201407065  1
2015 Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2358-71. PMID 25673831 DOI: 10.1523/JNEUROSCI.5791-12.2015  1
2015 Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nature Neuroscience. 18: 423-34. PMID 25622143 DOI: 10.1038/nn.3930  1
2015 Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice Nature Neuroscience. 18: 1183-1189. DOI: 10.1038/nn.4067  1
2014 Cheng JS, Craft R, Yu GQ, Ho K, Wang X, Mohan G, Mangnitsky S, Ponnusamy R, Mucke L. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. Plos One. 9: e115765. PMID 25551452 DOI: 10.1371/journal.pone.0115765  1
2014 Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature Medicine. 20: 1157-64. PMID 25261995 DOI: 10.1038/nm.3672  1
2014 Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L. Tau reduction prevents disease in a mouse model of Dravet syndrome. Annals of Neurology. 76: 443-56. PMID 25042160 DOI: 10.1002/ana.24230  1
2014 Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, ... ... Mucke L, et al. Life extension factor klotho enhances cognition. Cell Reports. 7: 1065-76. PMID 24813892 DOI: 10.1016/j.celrep.2014.03.076  1
2013 Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, ... ... Mucke L, et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. Jama Neurology. 70: 1158-66. PMID 23835471 DOI: 10.1001/jamaneurol.2013.136  1
2013 Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Nature Neuroscience. 16: 613-21. PMID 23525040 DOI: 10.1038/nn.3356  1
2013 Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiology of Aging. 34: 1523-9. PMID 23332171 DOI: 10.1016/j.neurobiolaging.2012.12.003  1
2012 Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. Plos One. 7: e45881. PMID 23029293 DOI: 10.1371/journal.pone.0045881  1
2012 Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proceedings of the National Academy of Sciences of the United States of America. 109: E2895-903. PMID 22869752 DOI: 10.1073/pnas.1121081109  1
2012 Mucke L, Selkoe DJ. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harbor Perspectives in Medicine. 2: a006338. PMID 22762015 DOI: 10.1101/cshperspect.a006338  1
2012 Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 149: 708-21. PMID 22541439 DOI: 10.1016/j.cell.2012.02.046  1
2012 Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell. 148: 1204-22. PMID 22424230 DOI: 10.1016/j.cell.2012.02.040  1
2012 Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. Selective targeting of microglia by quantum dots. Journal of Neuroinflammation. 9: 22. PMID 22272874 DOI: 10.1186/1742-2094-9-22  1
2011 Morris M, Koyama A, Masliah E, Mucke L. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. Plos One. 6: e29257. PMID 22206005 DOI: 10.1371/journal.pone.0029257  1
2011 Cissé M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L. Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10427-31. PMID 21775587 DOI: 10.1523/JNEUROSCI.1459-11.2011  1
2011 Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron. 70: 410-26. PMID 21555069 DOI: 10.1016/j.neuron.2011.04.009  1
2011 Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 700-11. PMID 21228179 DOI: 10.1523/JNEUROSCI.4152-10.2011  1
2011 Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 469: 47-52. PMID 21113149 DOI: 10.1038/nature09635  1
2011 Palop JJ, Mucke L, Roberson ED. Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. Methods in Molecular Biology (Clifton, N.J.). 670: 245-62. PMID 20967595 DOI: 10.1007/978-1-60761-744-0_17  1
2010 Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop JJ, Masliah E, Mucke L. Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron. 68: 428-41. PMID 21040845 DOI: 10.1016/j.neuron.2010.10.020  1
2010 Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. Tau reduction prevents Abeta-induced defects in axonal transport. Science (New York, N.Y.). 330: 198. PMID 20829454 DOI: 10.1126/science.1194653  1
2010 Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. The American Journal of Pathology. 177: 563-9. PMID 20595630 DOI: 10.2353/ajpath.2010.090973  1
2010 Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature Neuroscience. 13: 812-8. PMID 20581818 DOI: 10.1038/nn.2583  1
2010 Sanchez-Mejia RO, Mucke L. Phospholipase A2 and arachidonic acid in Alzheimer's disease. Biochimica Et Biophysica Acta. 1801: 784-90. PMID 20553961 DOI: 10.1016/j.bbalip.2010.05.013  1
2010 Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 372-81. PMID 20053918 DOI: 10.1523/JNEUROSCI.5341-09.2010  1
2010 Palop JJ, Mucke L. Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin? Neuromolecular Medicine. 12: 48-55. PMID 19838821 DOI: 10.1007/s12017-009-8097-7  1
2009 Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 5: 624-33. PMID 19951690 DOI: 10.1016/j.stem.2009.10.003  1
2009 Mucke L. Neuroscience: Alzheimer's disease. Nature. 461: 895-7. PMID 19829367 DOI: 10.1038/461895a  1
2009 Cisse M, Mucke L. Alzheimer's disease: A prion protein connection. Nature. 457: 1090-1. PMID 19242462 DOI: 10.1038/4571090a  1
2009 Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1977-86. PMID 19228952 DOI: 10.1523/JNEUROSCI.2984-08.2009  1
2009 Palop JJ, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Archives of Neurology. 66: 435-40. PMID 19204149 DOI: 10.1001/archneurol.2009.15  1
2009 Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity. Nature Neuroscience. 12: 119-21. PMID 19122666 DOI: 10.1038/nn.2240  1
2008 Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nature Neuroscience. 11: 1311-8. PMID 18931664 DOI: 10.1038/nn.2213  1
2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, ... ... Mucke L, et al. Genes contributing to prion pathogenesis. The Journal of General Virology. 89: 1777-88. PMID 18559949 DOI: 10.1099/vir.0.2008/001255-0  1
2008 Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5007-17. PMID 18463254 DOI: 10.1523/JNEUROSCI.0590-08.2008  1
2008 Gan L, Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 58: 10-4. PMID 18400158 DOI: 10.1016/j.neuron.2008.03.015  1
2008 Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L. Abnormal social behaviors in mice lacking Fgf17. Genes, Brain, and Behavior. 7: 344-54. PMID 17908176 DOI: 10.1111/j.1601-183X.2007.00357.x  1
2008 Deipolyi AR, Fang S, Palop JJ, Yu GQ, Wang X, Mucke L. Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiology of Aging. 29: 253-66. PMID 17126954 DOI: 10.1016/j.neurobiolaging.2006.10.021  1
2007 deIpolyi AR, Rankin KP, Mucke L, Miller BL, Gorno-Tempini ML. Spatial cognition and the human navigation network in AD and MCI. Neurology. 69: 986-97. PMID 17785667 DOI: 10.1212/01.wnl.0000271376.19515.c6  1
2007 Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 55: 697-711. PMID 17785178 DOI: 10.1016/j.neuron.2007.07.025  1
2007 Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. The Journal of Biological Chemistry. 282: 23818-28. PMID 17548355 DOI: 10.1074/jbc.M701078200  1
2007 Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science (New York, N.Y.). 316: 750-4. PMID 17478722 DOI: 10.1126/science.1141736  1
2007 Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L. Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2727-33. PMID 17360894 DOI: 10.1523/JNEUROSCI.3758-06.2007  1
2006 Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease. Science (New York, N.Y.). 314: 781-4. PMID 17082448 DOI: 10.1126/science.1132813  1
2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. The Journal of Clinical Investigation. 116: 3060-9. PMID 17080199 DOI: 10.1172/JCI27341  1
2006 Palop JJ, Chin J, Mucke L. A network dysfunction perspective on neurodegenerative diseases. Nature. 443: 768-73. PMID 17051202 DOI: 10.1038/nature05289  1
2006 Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 51: 703-14. PMID 16982417 DOI: 10.1016/j.neuron.2006.07.027  1
2006 Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO. PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 8215-20. PMID 16698938 DOI: 10.1073/pnas.0509725103  1
2006 Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5167-79. PMID 16687508 DOI: 10.1523/JNEUROSCI.0482-06.2006  1
2006 Morris R, Mucke L. Alzheimer's disease: A needle from the haystack. Nature. 440: 284-5. PMID 16541054 DOI: 10.1038/440284a  1
2005 Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9694-703. PMID 16237174 DOI: 10.1523/JNEUROSCI.2980-05.2005  1
2005 Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L. Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9686-93. PMID 16237173 DOI: 10.1523/JNEUROSCI.2829-05.2005  1
2005 Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. The Journal of Biological Chemistry. 280: 40364-74. PMID 16183991 DOI: 10.1074/jbc.M509329200  1
2005 Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. The Journal of Biological Chemistry. 280: 32957-67. PMID 16027115 DOI: 10.1074/jbc.M507016200  1
2004 Esposito L, Gan L, Yu GQ, Essrich C, Mucke L. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. Journal of Neurochemistry. 91: 1260-74. PMID 15584903 DOI: 10.1111/j.1471-4159.2004.02816.x  1
2004 Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nature Medicine. 10: 1190-2. PMID 15502844 DOI: 10.1038/nm1123  1
2004 Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, ... Mucke L, et al. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. The Embo Journal. 23: 4096-105. PMID 15457210 DOI: 10.1038/sj.emboj.7600415  1
2004 Mucke L, Pitas RE. Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD. Neuron. 43: 596-9. PMID 15339638 DOI: 10.1016/j.neuron.2004.08.025  1
2004 Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 23: 189-204. PMID 15181247 DOI: 10.1385/JMN:23:3:189  1
2004 Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4692-7. PMID 15140940 DOI: 10.1523/JNEUROSCI.0277-04.2004  1
2004 Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2527-34. PMID 15014128 DOI: 10.1523/JNEUROSCI.4315-03.2004  1
2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10966-71. PMID 12939405 DOI: 10.1073/pnas.1434398100  1
2003 Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proceedings of the National Academy of Sciences of the United States of America. 100: 9572-7. PMID 12881482 DOI: 10.1073/pnas.1133381100  1
2002 Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10539-48. PMID 12486146  1
2002 Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron. 35: 419-32. PMID 12165466 DOI: 10.1016/S0896-6273(02)00794-8  1
2002 Raber J, Bongers G, LeFevour A, Buttini M, Mucke L. Androgens protect against apolipoprotein E4-induced cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5204-9. PMID 12077215  1
2001 Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 12245-50. PMID 11572944 DOI: 10.1073/pnas.211412398  1
2001 Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nature Medicine. 7: 612-8. PMID 11329064 DOI: 10.1038/87945  1
2000 Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. The American Journal of Pathology. 157: 2003-10. PMID 11106573  1
2000 Wyss-Coray T, Mucke L. Ibuprofen, inflammation and Alzheimer disease. Nature Medicine. 6: 973-4. PMID 10973311 DOI: 10.1038/79661  1
2000 Wyss-Coray T, Lin C, von Euw D, Masliah E, Mucke L, Lacombe P. Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates. Annals of the New York Academy of Sciences. 903: 317-23. PMID 10818521  1
2000 Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4050-8. PMID 10818140  1
2000 Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L. Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience. 97: 207-10. PMID 10799751 DOI: 10.1016/S0306-4522(00)00069-5  1
2000 Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L. Apolipoprotein E and cognitive performance. Nature. 404: 352-4. PMID 10746713 DOI: 10.1038/35006165  1
2000 Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L. Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2064-71. PMID 10684907  1
2000 Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science (New York, N.Y.). 287: 1265-9. PMID 10678833 DOI: 10.1126/science.287.5456.1265  1
2000 Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. The American Journal of Pathology. 156: 139-50. PMID 10623661  1
1999 D'hooge R, Franck F, Mucke L, De Deyn PP. Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. The European Journal of Neuroscience. 11: 4398-402. PMID 10594667  1
1999 Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. The American Journal of Pathology. 155: 1741-7. PMID 10550330 DOI: 10.1016/S0002-9440(10)65489-2  1
1999 Sofroniew MV, Bush TG, Blumauer N, Lawrence Kruger, Mucke L, Johnson MH. Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice. Brain Research. 835: 91-5. PMID 10448200 DOI: 10.1016/S0006-8993(99)01639-X  1
1999 Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 23: 297-308. PMID 10399936 DOI: 10.1016/S0896-6273(00)80781-3  1
1999 Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 7547-52. PMID 10377452 DOI: 10.1073/pnas.96.13.7547  1
1999 Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4867-80. PMID 10366621  1
1999 Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proceedings of the National Academy of Sciences of the United States of America. 96: 3228-33. PMID 10077666 DOI: 10.1073/pnas.96.6.3228  1
1998 Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proceedings of the National Academy of Sciences of the United States of America. 95: 10914-9. PMID 9724804 DOI: 10.1073/pnas.95.18.10914  1
1998 Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L. Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis. The Journal of Biological Chemistry. 273: 12548-54. PMID 9575214 DOI: 10.1074/jbc.273.20.12548  1
1998 Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 93: 189-201. PMID 9568712 DOI: 10.1016/S0092-8674(00)81571-8  1
1998 Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L. Novel role of human CD4 molecule identified in neurodegeneration. Nature Medicine. 4: 441-6. PMID 9546790 DOI: 10.1038/nm0498-441  1
1998 Krucker T, Toggas SM, Mucke L, Siggins GR. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience. 83: 691-700. PMID 9483553 DOI: 10.1016/S0306-4522(97)00413-2  1
1997 Xu X, Raber J, Yang D, Su B, Mucke L. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proceedings of the National Academy of Sciences of the United States of America. 94: 12655-60. PMID 9356505 DOI: 10.1073/pnas.94.23.12655  1
1997 Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 389: 603-6. PMID 9335500 DOI: 10.1038/39321  1
1997 Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. The Embo Journal. 16: 6057-65. PMID 9321385 DOI: 10.1093/emboj/16.20.6057  1
1997 Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice . Journal of Neuroimmunology. 77: 45-50. PMID 9209267 DOI: 10.1016/S0165-5728(97)00049-0  1
1997 Raber J, Chen S, Mucke L, Feng L. Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. The Journal of Biological Chemistry. 272: 15057-60. PMID 9182522 DOI: 10.1074/jbc.272.24.15057  1
1997 Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 78: 135-46. PMID 9135095 DOI: 10.1016/S0306-4522(96)00553-2  1
1997 Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Research. Brain Research Reviews. 23: 47-61. PMID 9063586 DOI: 10.1016/S0165-0173(96)00014-8  1
1996 D'Hooge R, Nagels G, Westland CE, Mucke L, De Deyn PP. Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein. Neuroreport. 7: 2807-11. PMID 8981472  1
1996 Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L. Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. Virology. 226: 362-73. PMID 8955056 DOI: 10.1006/viro.1996.0664  1
1996 Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. The Journal of Biological Chemistry. 271: 31407-11. PMID 8940150 DOI: 10.1074/jbc.271.49.31407  1
1996 Masliah E, Ge N, Mucke L. Pathogenesis of HIV-1 associated neurodegeneration. Critical Reviews in Neurobiology. 10: 57-67. PMID 8853954  1
1996 Toggas SM, Masliah E, Mucke L. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Research. 706: 303-7. PMID 8822372 DOI: 10.1016/0006-8993(95)01197-8  1
1996 Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5795-811. PMID 8795633  1
1996 Mucke L, Abraham CR, Masliah E. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Annals of the New York Academy of Sciences. 777: 82-8. PMID 8624131  1
1996 Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, Mucke L. Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. The Journal of Clinical Investigation. 97: 789-98. PMID 8609236 DOI: 10.1172/JCI118478  1
1996 Toggas SM, Mucke L. Transgenic models in the study of AIDS dementia complex. Current Topics in Microbiology and Immunology. 206: 223-41. PMID 8608719  1
1995 Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 373: 523-7. PMID 7845465 DOI: 10.1038/373523a0  1
1995 Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L. Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes. Glia. 13: 174-84. PMID 7782103 DOI: 10.1002/glia.440130304  1
1995 Verderber L, Johnson W, Mucke L, Sarthy V. Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells. Investigative Ophthalmology & Visual Science. 36: 1137-43. PMID 7730023  1
1995 Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E. Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. The Journal of Experimental Medicine. 181: 1551-6. PMID 7699335 DOI: 10.1084/jem.181.4.1551  1
1995 Lipton SA, Brenneman DE, Silverstein FS, Masliah E, Mucke L. gp120 and neurotoxicity in vivo. Trends in Pharmacological Sciences. 16: 122. PMID 7610496 DOI: 10.1016/S0165-6147(00)88998-1  1
1995 Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. The American Journal of Pathology. 147: 53-67. PMID 7604885  1
1995 Rall GF, Mucke L, Oldstone MB. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. The Journal of Experimental Medicine. 182: 1201-12. PMID 7595191 DOI: 10.1084/jem.182.5.1201  1
1995 Borrow P, Cornell JL, Ruppe MD, Mucke L. Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes. Journal of Neuroimmunology. 61: 133-49. PMID 7593549 DOI: 10.1016/0165-5728(95)00082-D  1
1995 Mucke L, Masliah E, Campbell IL. Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines. Current Topics in Microbiology and Immunology. 202: 187-205. PMID 7587363  1
1995 Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MB. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron. 15: 1183-91. PMID 7576660 DOI: 10.1016/0896-6273(95)90105-1  1
1995 Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. The Journal of Biological Chemistry. 270: 28257-67. PMID 7499323 DOI: 10.1074/jbc.270.47.28257  1
1995 Lipton SA, Brenneman DE, Silverstein FS, Masliah E, Mucke L. gp120 and neurotoxicity in vivo. Consideration of animal models and technical methods in interpretation of negative data Trends in Pharmacological Sciences. 16: 122. DOI: 10.1016/S0165-6147(00)88998-1  1
1994 Rall GF, Mucke L, Nerenberg M, Oldstone MB. A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes. Journal of Neuroimmunology. 52: 61-8. PMID 8207120 DOI: 10.1016/0165-5728(94)90163-5  1
1994 Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 367: 188-93. PMID 8114918 DOI: 10.1038/367188a0  1
1994 Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Research. 666: 151-67. PMID 7882025 DOI: 10.1016/0006-8993(94)90767-6  1
1993 Eddleston M, Mucke L. Molecular profile of reactive astrocytes--implications for their role in neurologic disease. Neuroscience. 54: 15-36. PMID 8515840 DOI: 10.1016/0306-4522(93)90380-X  1
1993 Mucke L, Eddleston M. Astrocytes in infectious and immune-mediated diseases of the central nervous system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 7: 1226-32. PMID 8405808  1
1993 Abraham CR, Kanemaru K, Mucke L. Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes. Brain Research. 621: 222-32. PMID 8242336 DOI: 10.1016/0006-8993(93)90110-9  1
1993 Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proceedings of the National Academy of Sciences of the United States of America. 90: 10061-5. PMID 7694279  1
1993 Bloom FE, Campbell IL, Mucke L. Epilogue: Outlook, problems and future directions Discussions in Neuroscience. 9: 132-134.  1
1993 Campbell IL, Mucke L. Cell-cell communication in the immune system Discussions in Neuroscience. 9: 19-28.  1
1992 Mucke L, Oldstone MB. The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). Journal of Neuroimmunology. 36: 193-8. PMID 1732281 DOI: 10.1016/0165-5728(92)90050-U  1
1992 Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein. Annals of the New York Academy of Sciences. 674: 174-9. PMID 1288362 DOI: 10.1111/j.1749-6632.1992.tb27486.x  1
1991 Joly E, Mucke L, Oldstone MB. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science (New York, N.Y.). 253: 1283-5. PMID 1891717  1
1991 Mucke L, Oldstone MB, Morris JC, Nerenberg MI. Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury. The New Biologist. 3: 465-74. PMID 1883812  1
1990 Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 520-30. PMID 2303857  1
1988 Berger JR, Mucke L. Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy. Neurology. 38: 1060-5. PMID 3386823  1
1988 Benedek G, Mucke L, Norita M, Albowitz B, Creutzfeldt OD. Anterior ectosylvian visual area (AEV) of the cat: physiological properties. Progress in Brain Research. 75: 245-55. PMID 3187054  1
1988 Berger JR, Mucke L. Reply from the authors: Progressive multifocal leukoencephalopathy (PML) in AIDS Neurology. 38: 1897.  1
1987 Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH. Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiologica Scandinavica. 131: 631-2. PMID 3442246 DOI: 10.1111/j.1748-1716.1987.tb08288.x  1
1987 Mucke L, Maciewicz R. Clinical management of neuropathic pain. Neurologic Clinics. 5: 649-63. PMID 2828905  1
1986 Norita M, Mucke L, Benedek G, Albowitz B, Katoh Y, Creutzfeldt OD. Connections of the anterior ectosylvian visual area (AEV). Experimental Brain Research. 62: 225-40. PMID 3709710 DOI: 10.1007/BF00238842  1
1982 Mucke L, Norita M, Benedek G, Creutzfeldt O. Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat. Experimental Brain Research. 46: 1-11. PMID 7067781 DOI: 10.1007/BF00238092  1
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