Stefan Heller - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Auditory system, TRP channels

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Jan TA, Eltawil Y, Ling AH, Chen L, Ellwanger DC, Heller S, Cheng AG. Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics. Cell Reports. 36: 109358. PMID 34260939 DOI: 10.1016/j.celrep.2021.109358  0.359
2021 Benkafadar N, Janesick A, Scheibinger M, Ling AH, Jan TA, Heller S. Transcriptomic characterization of dying hair cells in the avian cochlea. Cell Reports. 34: 108902. PMID 33761357 DOI: 10.1016/j.celrep.2021.108902  0.374
2021 Janesick A, Scheibinger M, Benkafadar N, Kirti S, Ellwanger DC, Heller S. Cell-type identity of the avian cochlea. Cell Reports. 34: 108900. PMID 33761346 DOI: 10.1016/j.celrep.2021.108900  0.382
2021 Kubota M, Scheibinger M, Jan TA, Heller S. Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea. Cell Reports. 34: 108646. PMID 33472062 DOI: 10.1016/j.celrep.2020.108646  0.357
2020 Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature. PMID 32494013 DOI: 10.1038/S41586-020-2352-3  0.36
2019 Roccio M, Senn P, Heller S. Novel insights into inner ear development and regeneration for targeted hearing loss therapies. Hearing Research. 107859. PMID 31810596 DOI: 10.1016/j.heares.2019.107859  0.387
2019 Zhu Y, Scheibinger M, Ellwanger DC, Krey JF, Choi D, Kelly RT, Heller S, Barr-Gillespie PG. Single-cell proteomics reveals changes in expression during hair-cell development. Elife. 8. PMID 31682227 DOI: 10.7554/Elife.50777  0.739
2019 Senn P, Mina A, Volkenstein S, Kranebitter V, Oshima K, Heller S. Progenitor Cells from the Adult Human Inner Ear. Anatomical Record (Hoboken, N.J. : 2007). PMID 31489779 DOI: 10.1002/ar.24228  0.456
2019 Zhu Y, Scheibinger M, Ellwanger DC, Krey JF, Choi D, Kelly RT, Heller S, Barr-Gillespie PG. Author response: Single-cell proteomics reveals changes in expression during hair-cell development Elife. DOI: 10.7554/Elife.50777.029  0.655
2018 Durruthy-Durruthy R, Sperry ED, Bowen ME, Attardi LD, Heller S, Martin DM. Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Mutant Mouse Ear. Frontiers in Genetics. 9: 473. PMID 30459807 DOI: 10.3389/Fgene.2018.00473  0.436
2018 Roccio M, Perny M, Ealy M, Widmer HR, Heller S, Senn P. Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors. Nature Communications. 9: 4027. PMID 30279445 DOI: 10.1038/s41467-018-06334-7  0.467
2018 Janesick AS, Heller S. Stem Cells and the Bird Cochlea-Where Is Everybody? Cold Spring Harbor Perspectives in Medicine. PMID 30249599 DOI: 10.1101/cshperspect.a033183  0.458
2018 Hartman BH, Bӧscke R, Ellwanger DC, Keymeulen S, Scheibinger M, Heller S. Fbxo2 mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination. Developmental Biology. PMID 30179592 DOI: 10.1016/J.Ydbio.2018.08.013  0.778
2018 Ellwanger DC, Scheibinger M, Dumont RA, Barr-Gillespie PG, Heller S. Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails. Cell Reports. 23: 2901-2914.e14. PMID 29874578 DOI: 10.1016/J.Celrep.2018.05.002  0.728
2018 Lee J, Bӧscke R, Tang PC, Hartman BH, Heller S, Koehler KR. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids. Cell Reports. 22: 242-254. PMID 29298425 DOI: 10.1016/J.Celrep.2017.12.007  0.752
2017 Scheibinger M, Ellwanger DC, Corrales CE, Stone JS, Heller S. Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle. Journal of the Association For Research in Otolaryngology : Jaro. PMID 29134476 DOI: 10.1007/s10162-017-0646-4  0.452
2017 Meese S, Cepeda AP, Gahlen F, Adams CM, Ficner R, Ricci AJ, Heller S, Reisinger E, Herget M. Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca(2+) Affinity of the Multi-C2-Domain Protein Otoferlin. Frontiers in Synaptic Neuroscience. 9: 13. PMID 29046633 DOI: 10.3389/Fnsyn.2017.00013  0.605
2017 Chen CC, Butz ES, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C. Small Molecules for Early Endosome-Specific Patch Clamping. Cell Chemical Biology. 24: 907-916.e4. PMID 28732201 DOI: 10.1016/j.chembiol.2017.05.025  0.308
2016 DeJonge RE, Liu XP, Deig CR, Heller S, Koehler KR, Hashino E. Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture. Plos One. 11: e0162508. PMID 27607106 DOI: 10.1371/journal.pone.0162508  0.43
2016 Ealy M, Ellwanger DC, Kosaric N, Stapper AP, Heller S. Single-cell analysis delineates a trajectory toward the human early otic lineage. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402757 DOI: 10.1073/Pnas.1605537113  0.469
2015 Maass JC, Gu R, Basch ML, Waldhaus J, Lopez EM, Xia A, Oghalai JS, Heller S, Groves AK. Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea. Frontiers in Cellular Neuroscience. 9: 110. PMID 25873862 DOI: 10.3389/Fncel.2015.00110  0.452
2015 Hartman BH, Durruthy-Durruthy R, Laske RD, Losorelli S, Heller S. Identification and characterization of mouse otic sensory lineage genes. Frontiers in Cellular Neuroscience. 9: 79. PMID 25852475 DOI: 10.3389/Fncel.2015.00079  0.775
2014 Slattery EL, Oshima K, Heller S, Warchol ME. Cisplatin exposure damages resident stem cells of the mammalian inner ear. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 243: 1328-37. PMID 24888499 DOI: 10.1002/Dvdy.24150  0.421
2014 Durruthy-Durruthy R, Gottlieb A, Hartman BH, Waldhaus J, Laske RD, Altman R, Heller S. Reconstruction of the mouse otocyst and early neuroblast lineage at single-cell resolution. Cell. 157: 964-78. PMID 24768691 DOI: 10.1016/J.Cell.2014.03.036  0.762
2014 Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV. Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Molecular Biology of the Cell. 25: 1854-66. PMID 24743598 DOI: 10.1091/Mbc.E13-10-0609  0.358
2013 Volkenstein S, Oshima K, Sinkkonen ST, Corrales CE, Most SP, Chai R, Jan TA, van Amerongen R, Cheng AG, Heller S. Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus. Proceedings of the National Academy of Sciences of the United States of America. 110: 14456-61. PMID 23940359 DOI: 10.1073/Pnas.1307376110  0.393
2013 Herget M, Scheibinger M, Guo Z, Jan TA, Adams CM, Cheng AG, Heller S. A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis. Plos One. 8: e66026. PMID 23750277 DOI: 10.1371/Journal.Pone.0066026  0.457
2013 Guo Z, Grimm C, Becker L, Ricci AJ, Heller S. A novel ion channel formed by interaction of TRPML3 with TRPV5. Plos One. 8: e58174. PMID 23469151 DOI: 10.1371/Journal.Pone.0058174  0.585
2013 Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development (Cambridge, England). 140: 1196-206. PMID 23444352 DOI: 10.1242/Dev.087528  0.486
2013 Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S, Xu Z. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Plos One. 8: e56516. PMID 23437151 DOI: 10.1371/journal.pone.0056516  0.319
2012 Bermingham-McDonogh O, Corwin JT, Hauswirth WW, Heller S, Reed R, Reh TA. Regenerative medicine for the special senses: restoring the inputs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14053-7. PMID 23055472 DOI: 10.1523/Jneurosci.3336-12.2012  0.511
2011 Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske RD, Gahlen F, Sinkkonen W, Cheng AG, Oshima K, Heller S. Intrinsic regenerative potential of murine cochlear supporting cells. Scientific Reports. 1: 26. PMID 22355545 DOI: 10.1038/Srep00026  0.779
2011 Monk KR, Oshima K, Jörs S, Heller S, Talbot WS. Gpr126 is essential for peripheral nerve development and myelination in mammals. Development (Cambridge, England). 138: 2673-80. PMID 21613327 DOI: 10.1242/Dev.062224  0.322
2010 Lee KP, Nair AV, Grimm C, van Zeeland F, Heller S, Bindels RJ, Hoenderop JG. A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation. Cell Calcium. 48: 275-87. PMID 21035851 DOI: 10.1016/j.ceca.2010.09.007  0.305
2010 Xu Z, Oshima K, Heller S. PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23. Bmc Cell Biology. 11: 80. PMID 20958966 DOI: 10.1186/1471-2121-11-80  0.372
2010 Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell. 141: 704-16. PMID 20478259 DOI: 10.1016/J.Cell.2010.03.035  0.789
2010 Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S. Small molecule activators of TRPML3. Chemistry & Biology. 17: 135-48. PMID 20189104 DOI: 10.1016/j.chembiol.2009.12.016  0.335
2009 Peng AW, Belyantseva IA, Hsu PD, Friedman TB, Heller S. Twinfilin 2 regulates actin filament lengths in cochlear stereocilia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15083-8. PMID 19955359 DOI: 10.1523/Jneurosci.2782-09.2009  0.721
2009 Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. Bmc Neuroscience. 10: 122. PMID 19778451 DOI: 10.1186/1471-2202-10-122  0.418
2009 Samie MA, Grimm C, Evans JA, Curcio-Morelli C, Heller S, Slaugenhaupt SA, Cuajungco MP. The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Pflã¼Gers Archiv : European Journal of Physiology. 459: 79-91. PMID 19763610 DOI: 10.1007/s00424-009-0716-5  0.371
2009 Brigande JV, Heller S. Quo vadis, hair cell regeneration? Nature Neuroscience. 12: 679-85. PMID 19471265 DOI: 10.1038/Nn.2311  0.411
2009 Xu Z, Ricci AJ, Heller S. Rethinking how hearing happens. Neuron. 62: 305-7. PMID 19447085 DOI: 10.1016/J.Neuron.2009.04.019  0.625
2008 Xu Z, Peng AW, Oshima K, Heller S. MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11269-76. PMID 18971469 DOI: 10.1523/Jneurosci.3833-08.2008  0.713
2007 Grimm C, Cuajungco MP, van Aken AF, Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S. A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 19583-8. PMID 18048323 DOI: 10.1073/Pnas.0709846104  0.623
2007 Wu L, Gao X, Brown RC, Heller S, O'Neil RG. Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. American Journal of Physiology. Renal Physiology. 293: F1699-713. PMID 17699550 DOI: 10.1152/ajprenal.00462.2006  0.365
2007 Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Journal of the Association For Research in Otolaryngology : Jaro. 8: 18-31. PMID 17171473 DOI: 10.1007/S10162-006-0058-3  0.474
2006 Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. Journal of Neurobiology. 66: 1489-500. PMID 17013931 DOI: 10.1002/neu.20310  0.404
2006 Zhao Y, Wang Y, Wang Z, Liu H, Shen Y, Li W, Heller S, Li H. Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro. Neuroreport. 17: 121-4. PMID 16407756 DOI: 10.1097/01.wnr.0000198439.44636.49  0.461
2005 Li H, Corrales CE, Wang Z, Zhao Y, Wang Y, Liu H, Heller S. BMP4 signaling is involved in the generation of inner ear sensory epithelia. Bmc Developmental Biology. 5: 16. PMID 16107213 DOI: 10.1186/1471-213X-5-16  0.467
2004 Li H, Liu H, Sage C, Huang M, Chen ZY, Heller S. Islet-1 expression in the developing chicken inner ear. The Journal of Comparative Neurology. 477: 1-10. PMID 15281076 DOI: 10.1002/Cne.20190  0.469
2004 Li H, Liu H, Corrales CE, Mutai H, Heller S. Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. Journal of Neurobiology. 60: 61-70. PMID 15188273 DOI: 10.1002/neu.20013  0.461
2004 Li H, Liu H, Balt S, Mann S, Corrales CE, Heller S. Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear. The Journal of Comparative Neurology. 468: 125-34. PMID 14648695 DOI: 10.1002/cne.10944  0.406
2003 Keresztes G, Mutai H, Hibino H, Hudspeth AJ, Heller S. Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system. Molecular and Cellular Neurosciences. 24: 687-95. PMID 14664818 DOI: 10.1016/S1044-7431(03)00231-8  0.592
2003 Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10175-81. PMID 14614075 DOI: 10.1523/Jneurosci.23-32-10175.2003  0.306
2003 Li H, Roblin G, Liu H, Heller S. Generation of hair cells by stepwise differentiation of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 13495-500. PMID 14593207 DOI: 10.1073/pnas.2334503100  0.481
2003 Fuhrmann S, Stark MR, Heller S. Expression of Frizzled genes in the developing chick eye. Gene Expression Patterns : Gep. 3: 659-62. PMID 12972002 DOI: 10.1016/S1567-133X(03)00107-8  0.317
2003 Li H, Liu H, Heller S. Pluripotent stem cells from the adult mouse inner ear. Nature Medicine. 9: 1293-9. PMID 12949502 DOI: 10.1038/nm925  0.474
2002 Heller S, Bell AM, Denis CS, Choe Y, Hudspeth AJ. Parvalbumin 3 is an abundant Ca2+ buffer in hair cells. Journal of the Association For Research in Otolaryngology : Jaro. 3: 488-98. PMID 12072915 DOI: 10.1007/s10162-002-2050-x  0.669
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  0.321
2000 Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 103: 525-35. PMID 11081638 DOI: 10.1016/S0092-8674(00)00143-4  0.668
2000 Robertson NG, Heller S, Lin JS, Resendes BL, Weremowicz S, Denis CS, Bell AM, Hudspeth AJ, Morton CC. A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. Genomics. 66: 242-8. PMID 10873378 DOI: 10.1006/geno.2000.6224  0.576
1998 Fuhrmann S, Heller S, Rohrer H, Hofmann HD. A transient role for ciliary neurotrophic factor in chick photoreceptor development. Journal of Neurobiology. 37: 672-83. PMID 9858267 DOI: 10.1002/(Sici)1097-4695(199812)37:4<672::Aid-Neu14>3.0.Co;2-1  0.579
1998 Geissen M, Heller S, Pennica D, Ernsberger U, Rohrer H. The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling. Development (Cambridge, England). 125: 4791-801. PMID 9806927  0.515
1998 Robertson NG, Lu L, Heller S, Merchant SN, Eavey RD, McKenna M, Nadol JB, Miyamoto RT, Linthicum FH, Lubianca Neto JF, Hudspeth AJ, Seidman CE, Morton CC, Seidman JG. Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nature Genetics. 20: 299-303. PMID 9806553 DOI: 10.1038/3118  0.561
1998 Fuhrmann S, Kirsch M, Heller S, Rohrer H, Hofmann HD. Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during development of the chick retina. The Journal of Comparative Neurology. 400: 244-54. PMID 9766402 DOI: 10.1002/(Sici)1096-9861(19981019)400:2<244::Aid-Cne6>3.0.Co;2-9  0.613
1998 Heller S, Sheane CA, Javed Z, Hudspeth AJ. Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Proceedings of the National Academy of Sciences of the United States of America. 95: 11400-5. PMID 9736748 DOI: 10.1073/pnas.95.19.11400  0.615
1998 Heller S, Hudspeth AJ. Two deaf mice, two deaf mice... Nature Medicine. 4: 560-1. PMID 9585227 DOI: 10.1038/nm0598-560  0.501
1997 Rosenblatt KP, Sun ZP, Heller S, Hudspeth AJ. Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea. Neuron. 19: 1061-75. PMID 9390519 DOI: 10.1016/S0896-6273(00)80397-9  0.588
1997 Holst A, Heller S, Junghans D, Geissen M, Ernsberger U, Rohrer H. Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia. Developmental Biology. 191: 1-13. PMID 9356167 DOI: 10.1006/Dbio.1997.8714  0.543
1996 Heller S, Ernsberger U, Rohrer H. Extrinsic signals in the developing nervous system: the role of neurokines during neurogenesis. Perspectives On Developmental Neurobiology. 4: 19-34. PMID 9169916  0.462
1995 Heller S, Finn TP, Huber J, Nishi R, Geissen M, Püschel AW, Rohrer H. Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development. Development (Cambridge, England). 121: 2681-93. PMID 7671828  0.49
1993 Heller S, Huber J, Finn TP, Nishi R, Rohrer H. GPA and CNTF produce similar effects in sympathetic neurones but differ in receptor binding. Neuroreport. 5: 357-60. PMID 8298104 DOI: 10.1097/00001756-199312000-00045  0.532
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