Jeffrey R. Holt - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
sensory hair cells
Website:
https://sites.google.com/site/holtgeleoclab/people

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nature Communications. 10: 734. PMID 30737404 DOI: 10.1038/s41467-019-08716-x  0.56
2019 Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nature Communications. 10: 236. PMID 30670701 DOI: 10.1038/s41467-018-08264-w  0.56
2019 Holt JR, Geleoc GS. Split otoferlins reunited. Embo Molecular Medicine. 11. PMID 30573543 DOI: 10.15252/emmm.201809995  0.32
2018 Corey DP, Akyuz N, Holt JR. Function and Dysfunction of TMC Channels in Inner Ear Hair Cells. Cold Spring Harbor Perspectives in Medicine. PMID 30291150 DOI: 10.1101/cshperspect.a033506  0.92
2018 Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 99: 736-753.e6. PMID 30138589 DOI: 10.1016/j.neuron.2018.07.033  0.92
2018 Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. Scientific Reports. 8: 12124. PMID 30108254 DOI: 10.1038/s41598-018-28958-x  0.6
2018 Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ. Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Scientific Reports. 8: 12125. PMID 30108230 DOI: 10.1038/s41598-018-29709-8  0.56
2018 Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A. Regenerating hair cells in human vestibular sensory epithelia. Elife. 7. PMID 30019672 DOI: 10.7554/eLife.34817  0.4
2017 Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, ... ... Holt JR, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. PMID 29258297 DOI: 10.1038/nature25164  0.56
2017 Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nature Biotechnology. PMID 28459451 DOI: 10.1038/nbt.3840  0.56
2017 Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nature Biotechnology. PMID 28165476 DOI: 10.1038/nbt.3801  0.56
2017 Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nature Biotechnology. PMID 28165475 DOI: 10.1038/nbt.3781  0.56
2016 Corey DP, Holt JR. Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10921-10926. PMID 27798174 DOI: 10.1523/JNEUROSCI.1148-16.2016  0.92
2016 Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJ. RNA Interference Prevents Autosomal-Dominant Hearing Loss. American Journal of Human Genetics. PMID 27236922 DOI: 10.1016/j.ajhg.2016.03.028  0.56
2016 Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. Nature Communications. 7: 11508. PMID 27215798 DOI: 10.1038/ncomms11508  0.56
2016 Akyuz N, Holt JR. Plug-N-Play: Mechanotransduction Goes Modular. Neuron. 89: 1128-30. PMID 26985721 DOI: 10.1016/j.neuron.2016.02.041  0.44
2015 Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B. TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Reports. 12: 1606-17. PMID 26321635 DOI: 10.1016/j.celrep.2015.07.058  1
2015 Pan B, Holt JR. The molecules that mediate sensory transduction in the mammalian inner ear. Current Opinion in Neurobiology. 34: 165-71. PMID 26218316 DOI: 10.1016/j.conb.2015.06.013  1
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Science Translational Medicine. 7: 295ra108. PMID 26157030 DOI: 10.1126/scitranslmed.aab1996  0.56
2015 Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR. Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation. PflüGers Archiv : European Journal of Physiology. 467: 85-94. PMID 25074487 DOI: 10.1007/s00424-014-1582-3  1
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1996  1
2014 Géléoc GS, Holt JR. Sound strategies for hearing restoration. Science (New York, N.Y.). 344: 1241062. PMID 24812404 DOI: 10.1126/science.1241062  1
2014 Horwitz GC, Risner-Janiczek JR, Holt JR. Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons. The Journal of General Physiology. 143: 481-97. PMID 24638995 DOI: 10.1085/jgp.201311126  1
2014 Holt JR, Pan B, Koussa MA, Asai Y. TMC function in hair cell transduction. Hearing Research. 311: 17-24. PMID 24423408 DOI: 10.1016/j.heares.2014.01.001  1
2014 Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J. Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Human Molecular Genetics. 23: 2374-90. PMID 24334608 DOI: 10.1093/hmg/ddt629  1
2014 Gribelyuk MA, Ontalus V, Baumann FH, Zhu Z, Holt JR. Electron holography of devices with epitaxial layers Journal of Applied Physics. 116. DOI: 10.1063/1.4898859  0.32
2013 Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV. A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2: e01341. PMID 24327562 DOI: 10.7554/eLife.01341  1
2013 Kim YH, Holt JR. Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear. The Journal of General Physiology. 142: 207-23. PMID 23980193 DOI: 10.1085/jgp.201311019  1
2013 Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR. TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron. 79: 504-15. PMID 23871232 DOI: 10.1016/j.neuron.2013.06.019  1
2012 Holt JR, Vandenberghe LH. Gene therapy for deaf mice goes viral. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1836-7. PMID 23023054 DOI: 10.1038/mt.2012.196  1
2012 Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9485-98. PMID 22787034 DOI: 10.1523/JNEUROSCI.0311-12.2012  1
2012 Levin ME, Holt JR. The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear. Journal of Neurophysiology. 108: 175-86. PMID 22496522 DOI: 10.1152/jn.00098.2012  1
2011 Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ. Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. The Journal of Clinical Investigation. 121: 4796-809. PMID 22105175 DOI: 10.1172/JCI60405  1
2011 Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR. HCN channels expressed in the inner ear are necessary for normal balance function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16814-25. PMID 22090507 DOI: 10.1523/JNEUROSCI.3064-11.2011  1
2011 Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12241-50. PMID 21865467 DOI: 10.1523/JNEUROSCI.6531-10.2011  1
2011 Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, Srisailapathy CR, Oostrik J, Admiraal RJ, Neely HR, Latoche JR, Smith RJ, Northup JK, Kremer H, Holt JR, et al. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nature Communications. 2: 201. PMID 21326233 DOI: 10.1038/ncomms1200  1
2010 Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR. Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11259-69. PMID 20739546 DOI: 10.1523/JNEUROSCI.1949-10.2010  1
2010 Horwitz GC, Lelli A, Géléoc GS, Holt JR. HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear. Plos One. 5: e8627. PMID 20062532 DOI: 10.1371/journal.pone.0008627  1
2010 Asai Y, Holt JR, Géléoc GS. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Journal of the Association For Research in Otolaryngology : Jaro. 11: 27-37. PMID 19834762 DOI: 10.1007/s10162-009-0193-8  1
2010 Dube A, Chakravarti A, Takalkar R, Li J, Yang F, Madan A, Zhu Z, Loesing R, Murphy R, Adam TN, Black LR, Holt JR, Harley ECT, Stoker MW, Schepis DJ, et al. Epitaxial growth of Si:C alloys: Process development and challenges Ecs Transactions. 28: 63-71. DOI: 10.1149/1.3375589  0.32
2010 Stauffer EA, Lelli A, Holt JR. Hair Cell Transduction and Adaptation: Physiology and Molecular Mechanisms The Senses: a Comprehensive Reference. 3: 263-292. DOI: 10.1016/B978-012370880-9.00024-4  1
2010 Géléoc GSG, Holt JR. Hair Cells: Sensory Transduction Encyclopedia of Neuroscience. 1015-1020. DOI: 10.1016/B978-008045046-9.00255-2  1
2009 Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. Bmc Neuroscience. 10: 122. PMID 19778451 DOI: 10.1186/1471-2202-10-122  1
2009 Lelli A, Asai Y, Forge A, Holt JR, Géléoc GS. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. Journal of Neurophysiology. 101: 2961-73. PMID 19339464 DOI: 10.1152/jn.00136.2009  1
2009 Schwander M, Xiong W, Tokita J, Lelli A, Elledge HM, Kazmierczak P, Sczaniecka A, Kolatkar A, Wiltshire T, Kuhn P, Holt JR, Kachar B, Tarantino L, Müller U. A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 5252-7. PMID 19270079 DOI: 10.1073/pnas.0900691106  1
2009 Collado MS, Holt JR. Can neurosphere production help restore inner ear transduction? Proceedings of the National Academy of Sciences of the United States of America. 106: 8-9. PMID 19118205 DOI: 10.1073/pnas.0811804106  1
2008 Kesser BW, Hashisaki GT, Holt JR. Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy. The Laryngoscope. 118: 821-31. PMID 18300702 DOI: 10.1097/MLG.0b013e318164d0aa  1
2007 Stauffer EA, Holt JR. Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system. Journal of Neurophysiology. 98: 3360-9. PMID 17942617 DOI: 10.1152/jn.00914.2007  1
2007 Holt JR, Stauffer EA, Abraham D, Géléoc GS. Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8940-51. PMID 17699675 DOI: 10.1523/JNEUROSCI.2085-07.2007  1
2007 Kesser BW, Hashisaki GT, Fletcher K, Eppard H, Holt JR. An in vitro model system to study gene therapy in the human inner ear. Gene Therapy. 14: 1121-31. PMID 17568767 DOI: 10.1038/sj.gt.3302980  1
2007 Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Journal of the Association For Research in Otolaryngology : Jaro. 8: 18-31. PMID 17171473 DOI: 10.1007/s10162-006-0058-3  1
2006 Risner JR, Holt JR. Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons. Journal of Neurophysiology. 96: 2364-76. PMID 16855108 DOI: 10.1152/jn.00523.2006  1
2006 McGee J, Goodyear RJ, McMillan DR, Stauffer EA, Holt JR, Locke KG, Birch DG, Legan PK, White PC, Walsh EJ, Richardson GP. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6543-53. PMID 16775142 DOI: 10.1523/JNEUROSCI.0693-06.2006  1
2006 Senften M, Schwander M, Kazmierczak P, Lillo C, Shin JB, Hasson T, Géléoc GS, Gillespie PG, Williams D, Holt JR, Müller U. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2060-71. PMID 16481439 DOI: 10.1523/JNEUROSCI.4251-05.2006  1
2005 Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron. 47: 541-53. PMID 16102537 DOI: 10.1016/j.neuron.2005.07.024  1
2004 Géléoc GS, Risner JR, Holt JR. Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11148-59. PMID 15590931 DOI: 10.1523/JNEUROSCI.2662-04.2004  1
2004 Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 432: 723-30. PMID 15483558 DOI: 10.1038/nature03066  1
2003 Géléoc GS, Holt JR. Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nature Neuroscience. 6: 1019-20. PMID 12973354 DOI: 10.1038/nn1120  1
2003 Colclasure JC, Holt JR. Transduction and adaptation in sensory hair cells of the mammalian vestibular system. Gravitational and Space Biology Bulletin : Publication of the American Society For Gravitational and Space Biology. 16: 61-70. PMID 12959133  1
2003 Géléoc GS, Holt JR. Auditory amplification: outer hair cells pres the issue. Trends in Neurosciences. 26: 115-7. PMID 12591210 DOI: 10.1016/S0166-2236(03)00030-4  1
2002 Dumont RA, Zhao YD, Holt JR, Bähler M, Gillespie PG. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Journal of the Association For Research in Otolaryngology : Jaro. 3: 375-89. PMID 12486594 DOI: 10.1007/s101620020049  1
2002 Holt JR. Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiology & Neuro-Otology. 7: 157-60. PMID 12053137 DOI: 10.1159/000058302  1
2002 Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 108: 371-81. PMID 11853671 DOI: 10.1016/S0092-8674(02)00629-3  1
2001 Gillespie PG, Albanesi JP, Bahler M, Bement WM, Berg JS, Burgess DR, Burnside B, Cheney RE, Corey DP, Coudrier E, de Lanerolle P, Hammer JA, Hasson T, Holt JR, Hudspeth AJ, et al. Myosin-I nomenclature. The Journal of Cell Biology. 155: 703-4. PMID 11724811 DOI: 10.1083/jcb.200110032  1
2000 Huebner RC, Gray MA, Holt J, Wu XD, Mays JP. Characterization of a recombinant outer surface protein A (OspA) vaccine against Lyme disease. Developments in Biologicals. 103: 163-73. PMID 11214234  1
2000 Holt JR, Corey DP. Two mechanisms for transducer adaptation in vertebrate hair cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11730-5. PMID 11050202 DOI: 10.1073/pnas.97.22.11730  1
2000 Oghalai JS, Holt JR, Nakagawa T, Jung TM, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Harvesting human hair cells. The Annals of Otology, Rhinology, and Laryngology. 109: 9-16. PMID 10651405  1
1999 Holt JR, Vollrath MA, Eatock RA. Stimulus processing by type II hair cells in the mouse utricle. Annals of the New York Academy of Sciences. 871: 15-26. PMID 10372060 DOI: 10.1111/j.1749-6632.1999.tb09172.x  1
1999 Holt JR, Johns DC, Wang S, Chen ZY, Dunn RJ, Marban E, Corey DP. Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. Journal of Neurophysiology. 81: 1881-8. PMID 10200223  1
1999 Holt JR, Corey DP. Ion channel defects in hereditary hearing loss. Neuron. 22: 217-9. PMID 10069328  1
1998 Oghalai JS, Holt JR, Nakagawa T, Jung TM, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Ionic currents and electromotility in inner ear hair cells from humans. Journal of Neurophysiology. 79: 2235-9. PMID 9535985  1
1997 Holt JR, Corey DP, Eatock RA. Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8739-48. PMID 9348343  1
1995 Denk W, Holt JR, Shepherd GM, Corey DP. Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links. Neuron. 15: 1311-21. PMID 8845155 DOI: 10.1016/0896-6273(95)90010-1  1
1995 Holt JR, Eatock RA. Inwardly rectifying currents of saccular hair cells from the leopard frog. Journal of Neurophysiology. 73: 1484-502. PMID 7543944  1
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