Andrew Jenkins - Publications

Emory University, Atlanta, GA 
GABA receptors, Anesthetic mechanisms, ion channel function

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Perszyk RE, Yip MC, McConnell OL, Wang ET, Jenkins A, Traynelis SF, Forest CR. Automated intracellular pharmacological electrophysiology for ligand-gated ionotropic receptor and pharmacology screening. Molecular Pharmacology. PMID 33958481 DOI: 10.1124/molpharm.120.000195  0.787
2019 Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckols TA, Xu M, Martinson DE, Tranghese F, ... ... Jenkins A, et al. Modulating native GABA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. Journal of Neuro-Oncology. PMID 30725256 DOI: 10.1007/S11060-019-03115-0  0.772
2019 Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckois A, Xu M, Martinson DE, Tranghese F, ... ... Jenkins A, et al. Abstract 2623: Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death Cancer Research. 79: 2623-2623. DOI: 10.1158/1538-7445.Am2019-2623  0.363
2019 Burnhamm A, Kaluzova M, Kallay L, Li G, Ahmed T, Rashid F, Jenkins A, Cook J, Krummel DP, Sengupta S. Abstract 255: Antagonizing Na-K-Cl cotransporter NKCC1 impairs medulloblastoma cell viability Cancer Research. 79: 255-255. DOI: 10.1158/1538-7445.Am2019-255  0.325
2018 Moody OA, Jenkins A. The role of loops B and C in determining the potentiation of GABA receptors by midazolam. Pharmacology Research & Perspectives. 6: e00433. PMID 30459951 DOI: 10.1002/prp2.433  0.781
2018 Butler KM, Moody OA, Schuler E, Coryell J, Alexander JJ, Jenkins A, Escayg A. De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy. Brain : a Journal of Neurology. PMID 29961870 DOI: 10.1093/Brain/Awy171  0.784
2018 Singh A, Jenkins MA, Burke KJ, Beck G, Jenkins A, Scimemi A, Traynelis SF, Papa SM. Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Reports. 22: 941-952. PMID 29386136 DOI: 10.1016/J.Celrep.2017.12.095  0.507
2018 Kallay L, Keskin H, Ross A, Moody O, Cottrill K, Nuckols A, Li G, Ahmed T, Rashid F, Stephen M, Xu M, Martinson D, Macdonald T, Kowalski J, Wang X, ... ... Jenkins A, et al. PDTM-45. POSITIVE MODULATION OF NATIVE GABAA RECEPTORS IN MEDULLOBLASTOMA CANCER CELLS WITH BENZODIAZEPINES INDUCES RAPID MITOCHONDRIAL FRAGMENTATION AND TP53-DEPENDENT, CELL CYCLE-INDEPENDENT APOPTOSIS Neuro-Oncology. 20: vi213-vi213. DOI: 10.1093/Neuonc/Noy148.884  0.753
2017 Moody OA, Talwar S, Jenkins MA, Freeman AA, Trotti LM, García PS, Bliwise D, Lynch JW, Cherson B, Hernandez EM, Feldman N, Saini P, Rye DB, Jenkins A. Rigor, Reproducibility and in vitro CSF assays: The Devil in the Details. Annals of Neurology. PMID 28440033 DOI: 10.1002/Ana.24940  0.719
2017 Safavynia SA, Keating G, Speigel I, Fidler JA, Kreuzer M, Rye DB, Jenkins A, García PS. In Reply. Anesthesiology. 126: 352-353. PMID 28098616 DOI: 10.1097/ALN.0000000000001446  0.686
2017 Kallay L, Ross A, Moody O, Li G, Cook J, MacDonald T, Jenkins A, Krummel DP, Sengupta S. PATH-50. UNDERSTANDING THE MECHANISM OF BENZODIAZEPINE MEDIATED CELL DEATH IN GABRA5 OVEREXPRESSING GROUP 3 MEDULLOBLASTOMAS Neuro-Oncology. 19: vi182-vi182. DOI: 10.1093/Neuonc/Nox168.739  0.732
2017 McConnell O, Wang E, Bassell G, Moody O, Jenkins A, Freeman A, Trotti L, Saini P, Rye D. Impaired consciousness states in myotonic dystrophy-type 1 mediation by γ-amino butyric acid (GABA) Sleep Medicine. 40: e285. DOI: 10.1016/J.Sleep.2017.11.836  0.745
2016 Jenkins MA, Jenkins A. Anesthetic-Receptor Relationship Status: It's Complicated. Anesthesiology. PMID 27753643 DOI: 10.1097/Aln.0000000000001391  0.341
2016 Kolb I, Stoy WA, Rousseau EB, Moody OA, Jenkins A, Forest CR. Cleaning patch-clamp pipettes for immediate reuse. Scientific Reports. 6: 35001. PMID 27725751 DOI: 10.1038/Srep35001  0.741
2016 Safavynia SA, Keating G, Spiegel I, Fidler JA, Kreuzer M, Rye DB, Jenkins A, García PS. Effects of γ-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia. Anesthesiology. PMID 27111534 DOI: 10.1097/Aln.0000000000001134  0.62
2016 Kolb I, Stoy WA, Rousseau E, Moody OA, Jenkins A, Forest CR. Cleaning Patch Clamp Pipettes Enables their Reuse Biophysical Journal. 110: 149a. DOI: 10.1016/J.Bpj.2015.11.838  0.735
2015 Trotti LM, Saini P, Bliwise DL, Freeman AA, Jenkins A, Rye DB. Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. Annals of Neurology. PMID 26094838 DOI: 10.1002/Ana.24459  0.422
2015 Yuan H, Low CM, Moody OA, Jenkins A, Traynelis SF. Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases. Molecular Pharmacology. 88: 203-17. PMID 25904555 DOI: 10.1124/Mol.115.097998  0.791
2014 Jenkins MA, Wells G, Bachman J, Snyder JP, Jenkins A, Huganir RL, Oswald RE, Traynelis SF. Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Molecular Pharmacology. 85: 618-29. PMID 24452473 DOI: 10.1124/Mol.113.091488  0.57
2013 Trotti LM, Saini P, Freeman AA, Bliwise DL, García PS, Jenkins A, Rye DB. Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience. Journal of Psychopharmacology (Oxford, England). 28: 697-702. PMID 24306133 DOI: 10.1177/0269881113515062  0.39
2012 Rye DB, Bliwise DL, Parker K, Trotti LM, Saini P, Fairley J, Freeman A, Garcia PS, Owens MJ, Ritchie JC, Jenkins A. Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science Translational Medicine. 4: 161ra151. PMID 23175709 DOI: 10.1126/Scitranslmed.3004685  0.441
2012 Nash R, Krishnamoorthy M, Jenkins A, Csete M. Human embryonic stem cell model of ethanol-mediated early developmental toxicity. Experimental Neurology. 234: 127-35. PMID 22227564 DOI: 10.1016/J.Expneurol.2011.12.022  0.307
2012 O'Toole KK, Jenkins A. The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability. Molecular Pharmacology. 81: 189-97. PMID 22042665 DOI: 10.1124/mol.111.074476  0.591
2011 O'Toole KK, Jenkins A. Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function. The Journal of Biological Chemistry. 286: 37990-9. PMID 21903587 DOI: 10.1074/jbc.M111.258012  0.591
2011 Perszyk RE, Wiliams CA, Jenkins A. A conserved Asparagine Between Loops A and E of Anion Ligand-Gated Channels is Critical for Gaba(A) Receptor Function Biophysical Journal. 100: 271a. DOI: 10.1016/j.bpj.2010.12.1690  0.782
2010 Williams CA, Bell SV, Jenkins A. A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor. The Journal of Biological Chemistry. 285: 7281-7. PMID 20007704 DOI: 10.1074/jbc.M109.050294  0.485
2010 O'Toole K, Jenkins A. Effect of GABA Concentration on Current-Voltage Properties of the GABA(A) Receptor Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3863  0.591
2010 Williams CA, Jenkins A. Optimizing the State Identities in Markov Models of Macroscopic Ion Channel Activity Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3117  0.485
2009 O'Shea SM, Williams CA, Jenkins A. Inverse effects on gating and modulation caused by a mutation in the M2-M3 Linker of the GABA(A) receptor gamma subunit. Molecular Pharmacology. 76: 641-51. PMID 19553237 DOI: 10.1124/mol.109.055111  0.792
2008 Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI. General anesthetics have additive actions on three ligand gated ion channels. Anesthesia and Analgesia. 107: 486-93. PMID 18633027 DOI: 10.1213/Ane.0B013E31817B70C1  0.417
2008 Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM. Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesthesia and Analgesia. 107: 479-85. PMID 18633026 DOI: 10.1213/01.Ane.0000295805.70887.65  0.373
2008 Watt EE, Betts BA, Kotey FO, Humbert DJ, Griffith TN, Kelly EW, Veneskey KC, Gill N, Rowan KC, Jenkins A, Hall AC. Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol. European Journal of Pharmacology. 590: 120-6. PMID 18593637 DOI: 10.1016/j.ejphar.2008.06.003  0.448
2008 Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL. Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. Journal of Chemical Information and Modeling. 48: 344-9. PMID 18197653 DOI: 10.1021/ci700324a  0.573
2008 Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL. ChemInform Abstract: Molecular Modeling and Mutagenesis Reveals a Tetradentate Binding Site for Zn2+in GABAAαβ Receptors and Provides a Structural Basis for the Modulating Effect of the γ Subunit. Cheminform. 39. DOI: 10.1002/CHIN.200821214  0.538
2007 Richardson JE, Garcia PS, O'Toole KK, Derry JM, Bell SV, Jenkins A. A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol. Anesthesiology. 107: 412-8. PMID 17721243 DOI: 10.1097/01.anes.0000278875.36639.2c  0.591
2006 Sebel LE, Richardson JE, Singh SP, Bell SV, Jenkins A. Additive effects of sevoflurane and propofol on gamma-aminobutyric acid receptor function. Anesthesiology. 104: 1176-83. PMID 16732088 DOI: 10.1097/00000542-200606000-00012  0.478
2005 Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL. A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes, Brain, and Behavior. 4: 10-9. PMID 15660664 DOI: 10.1111/J.1601-183X.2004.00090.X  0.576
2005 Jenkins A, Kash TL, Schofield CM, Trudell JR, Harrison NL. Structural elements governing activation and modulation of GABAA receptors International Congress Series. 1283: 26-31. DOI: 10.1016/j.ics.2005.07.075  0.766
2003 Schofield CM, Jenkins A, Harrison NL. A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor. The Journal of Biological Chemistry. 278: 34079-83. PMID 12826676 DOI: 10.1074/Jbc.M302416200  0.796
2003 Topf N, Jenkins A, Baron N, Harrison NL. Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists. Anesthesiology. 98: 306-11. PMID 12552186 DOI: 10.1097/00000542-200302000-00007  0.648
2003 Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature. 421: 272-5. PMID 12529644 DOI: 10.1038/nature01280  0.731
2003 Kash TL, Jenkins A, Harrison NL. Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Brain Research. 960: 36-41. PMID 12505655 DOI: 10.1016/S0006-8993(02)03748-4  0.753
2002 Jenkins A, Andreasen A, Trudell JR, Harrison NL. Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology. 43: 669-78. PMID 12367612 DOI: 10.1016/S0028-3908(02)00175-2  0.646
2002 Nishikawa K, Jenkins A, Paraskevakis I, Harrison NL. Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations. Neuropharmacology. 42: 337-45. PMID 11897112 DOI: 10.1016/S0028-3908(01)00189-7  0.639
2002 Bertaccini EJ, Trudell JR, Jenkins A, Harrison NL. Docking of Anesthetics to a GABA Receptor Model Reproduces In Vitro Potency Order Anesthesiology. 96: A116. DOI: 10.1097/00000542-200209002-00116  0.622
2001 Lingamaneni R, Krasowski MD, Jenkins A, Truong T, Giunta AL, Blackbeer J, MacIver MB, Harrison NL, Hemmings HC. Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia. Anesthesiology. 94: 1050-7. PMID 11465597 DOI: 10.1097/00000542-200106000-00020  0.69
2001 Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility. The Journal of Pharmacology and Experimental Therapeutics. 297: 338-51. PMID 11259561  0.592
2001 Jenkins A, Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: RC136. PMID 11245705 DOI: 10.1523/Jneurosci.21-06-J0002.2001  0.598
2000 Jenkins A, Harrison N. Room 224-226, 10/18/2000 10: 30 AM - 12: 00 PM (PD) Halothane Action at the GABAA Receptor is Determined by Side Chain Volume at α270  Anesthesiology. 93: A-809. DOI: 10.1097/00000542-200009001-00809  0.539
2000 Harrison N, Andreasen A, Viner A, Light A, Jenkins A. Room D, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Multiple Mutations Are Required to Remove Chloroform Sensitivity from GABAAReceptors  Anesthesiology. 93: A-754. DOI: 10.1097/00000542-200009001-00754  0.504
1999 Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A, Harrison NL. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue. Molecular Pharmacology. 56: 1087-93. PMID 10531417 DOI: 10.1124/Mol.56.5.1087  0.637
1999 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Preparation of barbiturate optical isomers and their effects on GABA(A) receptors. Anesthesiology. 90: 1714-22. PMID 10360871 DOI: 10.1097/00000542-199906000-00029  0.543
1999 Jenkins A, Franks NP, Lieb WR. Effects of temperature and volatile anesthetics on GABA(A) receptors. Anesthesiology. 90: 484-91. PMID 9952156 DOI: 10.1097/00000542-199902000-00024  0.543
1998 Franks NP, Jenkins A, Conti E, Lieb WR, Brick P. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophysical Journal. 75: 2205-11. PMID 9788915 DOI: 10.1016/S0006-3495(98)77664-7  0.532
1998 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology. 88: 708-17. PMID 9523815 DOI: 10.1097/00000542-199803000-00022  0.543
1996 Jenkins A, Franks NP, Lieb WR. Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. British Journal of Pharmacology. 117: 1507-15. PMID 8730747 DOI: 10.1111/J.1476-5381.1996.Tb15314.X  0.543
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