| Year |
Citation |
Score |
| 2019 |
Koutzoumis DN, Vergara M, Pino J, Buddendorff J, Khoshbouei H, Mandel RJ, Torres GE. Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease. Experimental Neurology. 113159. PMID 31843492 DOI: 10.1016/J.Expneurol.2019.113159 |
0.383 |
|
| 2017 |
Mandel RJ, Marmion DJ, Kirik D, Chu Y, Heindel C, McCown T, Gray SJ, Kordower JH. Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. Acta Neuropathologica Communications. 5: 47. PMID 28619074 DOI: 10.1186/S40478-017-0451-7 |
0.434 |
|
| 2016 |
Guadiana SM, Parker AK, Filho GF, Sequeira A, Semple-Rowland S, Shaw G, Mandel RJ, Foster TC, Kumar A, Sarkisian MR. Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia. Frontiers in Aging Neuroscience. 8: 127. PMID 27303293 DOI: 10.3389/Fnagi.2016.00127 |
0.31 |
|
| 2014 |
Gombash SE, Manfredsson FP, Mandel RJ, Collier TJ, Fischer DL, Kemp CJ, Kuhn NM, Wohlgenant SL, Fleming SM, Sortwell CE. Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways. Gene Therapy. 21: 682-93. PMID 24807806 DOI: 10.1038/Gt.2014.42 |
0.449 |
|
| 2014 |
Oliveria SF, Foote KD, Mandel R. 192 Stereotactic Striatal Injection of a Regulated Glial Derived Neurotrophic Factor Expression System Neurosurgery. 61: 223-224. DOI: 10.1227/01.Neu.0000452466.42032.53 |
0.355 |
|
| 2012 |
Manfredsson FP, Bloom DC, Mandel RJ. Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues. Neurobiology of Disease. 48: 212-21. PMID 22426391 DOI: 10.1016/J.Nbd.2012.03.001 |
0.408 |
|
| 2012 |
Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 544-54. PMID 22008908 DOI: 10.1038/Mt.2011.216 |
0.478 |
|
| 2011 |
Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Human Molecular Genetics. 20: 2770-82. PMID 21515588 DOI: 10.1093/Hmg/Ddr176 |
0.301 |
|
| 2011 |
Manfredsson FP, Mandel RJ. The development of flexible lentiviral vectors for gene transfer in the CNS. Experimental Neurology. 229: 201-6. PMID 21459087 DOI: 10.1016/J.Expneurol.2011.03.013 |
0.435 |
|
| 2011 |
Mandel RJ, Lowenstein PR, Byrne BJ. AAV6-mediated gene silencing fALS short. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 231-3. PMID 21289637 DOI: 10.1038/Mt.2010.306 |
0.335 |
|
| 2011 |
Rising AC, Xu J, Carlson A, Napoli VV, Denovan-Wright EM, Mandel RJ. Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats. Experimental Neurology. 228: 173-82. PMID 21192926 DOI: 10.1016/J.Expneurol.2010.12.017 |
0.345 |
|
| 2010 |
Gorbatyuk OS, Li S, Nguyen FN, Manfredsson FP, Kondrikova G, Sullivan LF, Meyers C, Chen W, Mandel RJ, Muzyczka N. α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1758-68. PMID 20664530 DOI: 10.1038/Mt.2010.137 |
0.403 |
|
| 2010 |
Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-7. PMID 20551914 DOI: 10.1038/Mt.2010.115 |
0.355 |
|
| 2010 |
Dodiya HB, Bjorklund T, Stansell J, Mandel RJ, Kirik D, Kordower JH. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 579-87. PMID 19773746 DOI: 10.1038/Mt.2009.216 |
0.473 |
|
| 2009 |
Manfredsson FP, Okun MS, Mandel RJ. Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson's disease. Current Gene Therapy. 9: 375-88. PMID 19860652 DOI: 10.2174/156652309789753400 |
0.424 |
|
| 2009 |
Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1857-67. PMID 19707186 DOI: 10.1038/Mt.2009.196 |
0.446 |
|
| 2009 |
Björklund T, Hall H, Breysse N, Soneson C, Carlsson T, Mandel RJ, Carta M, Kirik D. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats. Journal of Neurochemistry. 111: 355-67. PMID 19686242 DOI: 10.1111/J.1471-4159.2009.06340.X |
0.423 |
|
| 2009 |
Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 980-91. PMID 19277011 DOI: 10.1038/Mt.2009.45 |
0.355 |
|
| 2009 |
Manfredsson FP, Rising AC, Mandel RJ. AAV9: a potential blood-brain barrier buster. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 403-5. PMID 19247366 DOI: 10.1038/Mt.2009.15 |
0.342 |
|
| 2009 |
Leriche L, Björklund T, Breysse N, Besret L, Grégoire MC, Carlsson T, Dollé F, Mandel RJ, Déglon N, Hantraye P, Kirik D. Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1544-53. PMID 19193901 DOI: 10.1523/Jneurosci.4491-08.2009 |
0.415 |
|
| 2009 |
Peden CS, Manfredsson FP, Reimsnider SK, Poirier AE, Burger C, Muzyczka N, Mandel RJ. Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 524-37. PMID 19142181 DOI: 10.1038/Mt.2008.284 |
0.387 |
|
| 2008 |
Denovan-Wright EM, Attis M, Rodriguez-Lebron E, Mandel RJ. Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice. Journal of Neuroscience Research. 86: 1748-57. PMID 18293418 DOI: 10.1002/Jnr.21636 |
0.393 |
|
| 2008 |
Burger C, Lopez MC, Baker HV, Mandel RJ, Muzyczka N. Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus. Neurobiology of Learning and Memory. 89: 379-96. PMID 18234529 DOI: 10.1016/J.Nlm.2007.11.006 |
0.313 |
|
| 2008 |
Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, Mandel RJ, Muzyczka N. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 763-8. PMID 18178617 DOI: 10.1073/Pnas.0711053105 |
0.396 |
|
| 2008 |
Denovan-Wright EM, Rodriguez-Lebron E, Lewin AS, Mandel RJ. Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo. Neurobiology of Disease. 29: 446-55. PMID 18166484 DOI: 10.1016/J.Nbd.2007.11.003 |
0.382 |
|
| 2008 |
Foust KD, Flotte TR, Reier PJ, Mandel RJ. Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat. Human Gene Therapy. 19: 71-82. PMID 18072858 DOI: 10.1089/Hum.2007.104 |
0.327 |
|
| 2008 |
Foust KD, Poirier A, Pacak CA, Mandel RJ, Flotte TR. Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons. Human Gene Therapy. 19: 61-70. PMID 18052722 DOI: 10.1089/Hum.2007.093 |
0.39 |
|
| 2008 |
Mandel RJ, Burger C, Snyder RO. Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production. Experimental Neurology. 209: 58-71. PMID 17916354 DOI: 10.1016/J.Expneurol.2007.08.008 |
0.436 |
|
| 2007 |
Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG. Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Current Gene Therapy. 7: 347-60. PMID 17979681 DOI: 10.2174/156652307782151498 |
0.396 |
|
| 2007 |
Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology. 207: 289-301. PMID 17678648 DOI: 10.1016/J.Expneurol.2007.06.019 |
0.452 |
|
| 2007 |
Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1504-11. PMID 17565350 DOI: 10.1038/Sj.Mt.6300227 |
0.445 |
|
| 2007 |
Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain : a Journal of Neurology. 130: 799-815. PMID 17303591 DOI: 10.1093/Brain/Awl382 |
0.349 |
|
| 2007 |
Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, Singleton AB. BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neuroscience Letters. 415: 59-63. PMID 17229524 DOI: 10.1016/J.Neulet.2006.12.038 |
0.315 |
|
| 2006 |
Kearns SM, Scheffler B, Goetz AK, Lin DD, Baker HD, Roper SN, Mandel RJ, Steindler DA. A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit. Journal of Neuroscience Methods. 157: 1-9. PMID 16704878 DOI: 10.1016/J.Jneumeth.2006.03.020 |
0.388 |
|
| 2006 |
Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K, Burger C. Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 463-83. PMID 16412695 DOI: 10.1016/J.Ymthe.2005.11.009 |
0.378 |
|
| 2006 |
Scholz SW, Xiromerisiou G, Fung HC, Eerola J, Hellström O, Papadimitriou A, Hadjigeorgiou GM, Tienari PJ, Fernandez HH, Mandel R, Okun MS, Gwinn-Hardy K, Singleton AB. The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations. Neuroscience Letters. 395: 227-9. PMID 16298483 DOI: 10.1016/J.Neulet.2005.10.081 |
0.31 |
|
| 2006 |
Manfredsson FP, Lewin AS, Mandel RJ. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Therapy. 13: 517-24. PMID 16267570 DOI: 10.1038/Sj.Gt.3302669 |
0.367 |
|
| 2006 |
Tümer N, Scarpace PJ, Dogan MD, Broxson CS, Matheny M, Yurek DM, Peden CS, Burger C, Muzyczka N, Mandel RJ. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiology of Aging. 27: 459-70. PMID 15964099 DOI: 10.1016/J.Neurobiolaging.2005.03.018 |
0.325 |
|
| 2006 |
Reimsnider SK, Manfredsson FP, Burger C, Muzczyka N, Mandel RJ. 903. Re-Administration of Recombinant AAV2 and AAV5 in the Brain Molecular Therapy. 13: S348. DOI: 10.1016/J.Ymthe.2006.08.992 |
0.381 |
|
| 2006 |
Manfredsson FP, Rising AC, Mandel RJ. 895. Separate rAAV1 Vectors Co-Infect Striatal Neurons Efficiently Molecular Therapy. 13: S345. DOI: 10.1016/J.Ymthe.2006.08.984 |
0.45 |
|
| 2006 |
Burger C, Piercefield E, Sullivan L, Mandel R, Muyczka N. 323. In Vivo Regulation of rAAV-Mediated GDNF Expression in the Rat Striatum Molecular Therapy. 13: S123. DOI: 10.1016/J.Ymthe.2006.08.380 |
0.407 |
|
| 2006 |
Manfredsson FP, Mandel RJ, Zolotukhin S, Lewin AS. 1032. rAAV Mediated Knock-Down of Tyrosine Hydroxylase in the Substantia Nigra Using a pol II Transcribed siRNA Molecular Therapy. 13: S396. DOI: 10.1016/J.Ymthe.2006.08.1127 |
0.403 |
|
| 2005 |
Burger C, Nash K, Mandel RJ. Recombinant adeno-associated viral vectors in the nervous system. Human Gene Therapy. 16: 781-91. PMID 16000060 DOI: 10.1089/Hum.2005.16.781 |
0.436 |
|
| 2005 |
Eslamboli A, Georgievska B, Ridley RM, Baker HF, Muzyczka N, Burger C, Mandel RJ, Annett L, Kirik D. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 769-77. PMID 15673656 DOI: 10.1523/Jneurosci.4421-04.2005 |
0.461 |
|
| 2005 |
Burger C, Nguyen FN, Deng J, Mandel RJ. Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 327-31. PMID 15668145 DOI: 10.1016/J.Ymthe.2004.08.031 |
0.47 |
|
| 2005 |
Carlsson T, Winkler C, Burger C, Muzyczka N, Mandel RJ, Cenci A, Björklund A, Kirik D. Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain : a Journal of Neurology. 128: 559-69. PMID 15659429 DOI: 10.1093/Brain/Awh374 |
0.447 |
|
| 2005 |
Reimsnider SK, Manfredsson F, Muzyczka N, Mandel RJ. 1082. Transduction Comparison of AAV Serotype Vectors in the Central Nervous System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.629 |
0.437 |
|
| 2005 |
Foust KD, Reier PJ, Mandel RJ, Flotte TR. 654. Quantifying GDNF Levels in the Spinal Cord after Intracerebral Delivery of rAAV5 GDNF Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.194 |
0.315 |
|
| 2005 |
Manfredsson FP, Lewin AS, Muzyczka N, Burger C, Mandel RJ. 59. rAAV-Mediated Nigral Parkin Over-Expression Is Neuroprotective in the 6-OHDA Rat Model of Parkinson's Disease Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.087 |
0.47 |
|
| 2005 |
Rodriguez E, Denovan-Wright E, Nash K, Lewin AS, Mandel RJ. 53. Post-Transcriptional Suppression of Striatal Mutant Huntingtin Leads to Mild Phenotypic Improvements in the R6/1 Mouse Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.081 |
0.382 |
|
| 2004 |
Rogaeva E, Johnson J, Lang AE, Gulick C, Gwinn-Hardy K, Kawarai T, Sato C, Morgan A, Werner J, Nussbaum R, Petit A, Okun MS, McInerney A, Mandel R, Groen JL, et al. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Archives of Neurology. 61: 1898-904. PMID 15596610 DOI: 10.1001/Archneur.61.12.1898 |
0.306 |
|
| 2004 |
Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 302-17. PMID 15294177 DOI: 10.1016/J.Ymthe.2004.05.024 |
0.432 |
|
| 2004 |
Peden CS, Burger C, Muzyczka N, Mandel RJ. Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. Journal of Virology. 78: 6344-59. PMID 15163728 DOI: 10.1128/Jvi.78.12.6344-6359.2004 |
0.403 |
|
| 2004 |
Toussaint NY, Kearns S, Scheffler B, Mandel R, Sullivan SM. 851. Development of Brain Tumor Organ Cultures for Characterizing Polymer/Plasmid DNA Mediated Gene Transfer Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.752 |
0.333 |
|
| 2004 |
Manfredsson FP, Lewin AS, Mandel RJ. 529. rAAV mediated parkin expression confers some protection in the rat 6-OHDA lesion model Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.476 |
0.439 |
|
| 2004 |
Kohlbrenner E, Aslanidi G, Knop DR, Gorbatyuk O, Nash K, Mandel RJ, Muzyczka N, Burns BJ, Snyder RO, Zolotukhin S. 420. Adaptation of Baculovirus System for Large-Scale Production of rAAV Vector Serotypes Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.340 |
0.329 |
|
| 2004 |
Foust KD, Mandel RJ, Reier PJ, Flotte TR. 1055. Anterograde Delivery of Gene Product by rAAV5 Vectors|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.1000 |
0.365 |
|
| 2003 |
Arvidsson A, Kirik D, Lundberg C, Mandel RJ, Andsberg G, Kokaia Z, Lindvall O. Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats. Neurobiology of Disease. 14: 542-56. PMID 14678770 DOI: 10.1016/J.Nbd.2003.08.002 |
0.412 |
|
| 2003 |
Eslamboli A, Cummings RM, Ridley RM, Baker HF, Muzyczka N, Burger C, Mandel RJ, Kirik D, Annett LE. Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus). Experimental Neurology. 184: 536-48. PMID 14637123 DOI: 10.1016/J.Expneurol.2003.08.007 |
0.436 |
|
| 2003 |
Gustafsson E, Andsberg G, Darsalia V, Mohapel P, Mandel RJ, Kirik D, Lindvall O, Kokaia Z. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. The European Journal of Neuroscience. 17: 2667-78. PMID 12823474 DOI: 10.1046/J.1460-9568.2003.02713.X |
0.389 |
|
| 2003 |
Matalon R, Surendran S, Rady PL, Quast MJ, Campbell GA, Matalon KM, Tyring SK, Wei J, Peden CS, Ezell EL, Muzyczka N, Mandel RJ. Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 580-7. PMID 12718900 DOI: 10.1016/S1525-0016(03)00066-2 |
0.365 |
|
| 2003 |
Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Björklund A. Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 2884-9. PMID 12601150 DOI: 10.1073/Pnas.0536383100 |
0.387 |
|
| 2002 |
Larsson E, Mandel RJ, Klein RL, Muzyczka N, Lindvall O, Kokaia Z. Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor. Experimental Neurology. 177: 1-8. PMID 12429205 DOI: 10.1006/Exnr.2002.7992 |
0.361 |
|
| 2002 |
Owen R, Mandel RJ, Ammini CV, Conlon TJ, Kerr DS, Stacpoole PW, Flotte TR. Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 394-9. PMID 12231176 DOI: 10.1006/Mthe.2002.0683 |
0.45 |
|
| 2002 |
Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Björklund A. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2780-91. PMID 11923443 DOI: 10.1523/Jneurosci.22-07-02780.2002 |
0.435 |
|
| 2002 |
Kirik D, Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel RJ, Bjorklund A. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 99: 4708-13. PMID 11917105 DOI: 10.1073/Pnas.062047599 |
0.404 |
|
| 2002 |
Andsberg G, Kokaia Z, Klein RL, Muzyczka N, Lindvall O, Mandel RJ. Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats. Neurobiology of Disease. 9: 187-204. PMID 11895371 DOI: 10.1006/Nbdi.2001.0456 |
0.416 |
|
| 2000 |
Englund U, Ericson C, Rosenblad C, Mandel RJ, Trono D, Wictorin K, Lundberg C. The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS. Neuroreport. 11: 3973-7. PMID 11192612 DOI: 10.1097/00001756-200012180-00014 |
0.443 |
|
| 2000 |
Björklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Research. 886: 82-98. PMID 11119690 DOI: 10.1016/S0006-8993(00)02915-2 |
0.518 |
|
| 2000 |
Klein RL, Mandel RJ, Muzyczka N. Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system. Advances in Virus Research. 55: 507-28. PMID 11050954 DOI: 10.1016/S0065-3527(00)55015-5 |
0.469 |
|
| 2000 |
Chen EY, Kallwitz E, Leff SE, Cochran EJ, Mufson EJ, Kordower JH, Mandel RJ. Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. The Journal of Comparative Neurology. 426: 534-48. PMID 11027397 DOI: 10.1002/1096-9861(20001030)426:4<534::Aid-Cne3>3.0.Co;2-G |
0.308 |
|
| 2000 |
Kirik D, Rosenblad C, Bjorklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4686-700. PMID 10844038 DOI: 10.1523/Jneurosci.20-12-04686.2000 |
0.381 |
|
| 2000 |
Mandel RJ. Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease. Experimental Neurology. 161: 212-9. PMID 10683287 DOI: 10.1006/Exnr.1999.7245 |
0.349 |
|
| 1999 |
Mandel RJ, Snyder RO, Leff SE. Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease. Experimental Neurology. 160: 205-14. PMID 10630205 DOI: 10.1006/Exnr.1999.7203 |
0.511 |
|
| 1999 |
Mandel RJ, Rendahl KG, Snyder RO, Leff SE. Progress in direct striatal delivery of L-dopa via gene therapy for treatment of Parkinson's disease using recombinant adeno-associated viral vectors. Experimental Neurology. 159: 47-64. PMID 10486174 DOI: 10.1006/Exnr.1999.7159 |
0.46 |
|
| 1999 |
Szczypka MS, Mandel RJ, Donahue BA, Snyder RO, Leff SE, Palmiter RD. Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Neuron. 22: 167-78. PMID 10027299 DOI: 10.1016/S0896-6273(00)80688-1 |
0.403 |
|
| 1999 |
Mandel RJ, Gage FH, Clevenger DG, Spratt SK, Snyder RO, Leff SE. Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration. Experimental Neurology. 155: 59-64. PMID 9918705 DOI: 10.1006/Exnr.1998.6961 |
0.393 |
|
| 1998 |
Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L, Trono D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. Journal of Virology. 72: 9873-80. PMID 9811723 DOI: 10.1128/Jvi.72.12.9873-9880.1998 |
0.368 |
|
| 1998 |
Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L. A third-generation lentivirus vector with a conditional packaging system. Journal of Virology. 72: 8463-71. PMID 9765382 DOI: 10.1128/Jvi.72.11.8463-8471.1998 |
0.369 |
|
| 1998 |
Rendahl KG, Leff SE, Otten GR, Spratt SK, Bohl D, Van Roey M, Donahue BA, Cohen LK, Mandel RJ, Danos O, Snyder RO. Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nature Biotechnology. 16: 757-61. PMID 9702775 DOI: 10.1038/Nbt0898-757 |
0.316 |
|
| 1998 |
Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK, Leff SE. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 4271-84. PMID 9592104 DOI: 10.1523/Jneurosci.18-11-04271.1998 |
0.466 |
|
| 1997 |
Mandel RJ, Spratt SK, Snyder RO, Leff SE. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proceedings of the National Academy of Sciences of the United States of America. 94: 14083-8. PMID 9391156 DOI: 10.1073/Pnas.94.25.14083 |
0.485 |
|
| 1997 |
Bankiewicz KS, Leff SE, Nagy D, Jungles S, Rokovich J, Spratt K, Cohen L, Libonati M, Snyder RO, Mandel RJ. Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease. Experimental Neurology. 144: 147-56. PMID 9126164 DOI: 10.1006/Exnr.1996.6401 |
0.472 |
|
| 1993 |
Bankiewicz K, Mandel RJ, Sofroniew MV. Trophism, transplantation, and animal models of Parkinson's disease. Experimental Neurology. 124: 140-9. PMID 8282071 DOI: 10.1006/Exnr.1993.1185 |
0.302 |
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