Nick P. Franks - Publications

Affiliations: 
Imperial College, London, London, England, United Kingdom 
Area:
Biophysics, Anesthesia Mechanisms, Structural Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Harding EC, Franks NP, Wisden W. Sleep and thermoregulation. Current Opinion in Physiology. 15: 7-13. PMID 32617439 DOI: 10.1016/J.Cophys.2019.11.008  0.826
2020 Yu X, Ba W, Zhao G, Ma Y, Harding EC, Yin L, Wang D, Li H, Zhang P, Shi Y, Yustos R, Vyssotski AL, Dong H, Franks NP, Wisden W. Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Molecular Psychiatry. PMID 32555422 DOI: 10.1038/S41380-020-0810-9  0.827
2020 Nollet M, Wisden W, Franks NP. Sleep deprivation and stress: a reciprocal relationship. Interface Focus. 10: 20190092. PMID 32382403 DOI: 10.1098/Rsfs.2019.0092  0.75
2020 Wisden W, Franks NP. The stillness of sleep. Science (New York, N.Y.). 367: 366-367. PMID 31974235 DOI: 10.1126/Science.Aba4485  0.749
2019 Ma Y, Miracca G, Yu X, Harding EC, Miao A, Yustos R, Vyssotski AL, Franks NP, Wisden W. Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation. Current Biology : Cb. PMID 31543455 DOI: 10.1016/J.Cub.2019.07.087  0.842
2019 Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W. Corrigendum: Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep. PMID 31152538 DOI: 10.1093/sleep/zsz107  0.828
2019 Harding EC, Franks NP, Wisden W. The Temperature Dependence of Sleep. Frontiers in Neuroscience. 13: 336. PMID 31105512 DOI: 10.3389/Fnins.2019.00336  0.831
2019 Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W. Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep. PMID 30722053 DOI: 10.1093/Sleep/Zsz031  0.836
2019 Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, ... ... Franks NP, et al. GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nature Neuroscience. 22: 106-119. PMID 30559475 DOI: 10.1038/S41593-018-0288-9  0.833
2018 Paul EJ, Kalk E, Tossell K, Irvine EE, Franks NP, Wisden W, Withers DJ, Leiper J, Ungless MA. nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta. Eneuro. 5. PMID 30456293 DOI: 10.1523/ENEURO.0381-18.2018  0.563
2018 Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y. Histamine: Neural circuits and new medications. Sleep. PMID 30239935 DOI: 10.1093/Sleep/Zsy183  0.652
2018 Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP. A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Current Biology : Cb. PMID 30017485 DOI: 10.1016/J.Cub.2018.05.054  0.842
2018 Yu X, Franks NP, Wisden W. Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems. Frontiers in Neural Circuits. 12: 4. PMID 29434539 DOI: 10.3389/Fncir.2018.00004  0.769
2018 Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP. Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Current Biology : Cb. PMID 29398217 DOI: 10.1016/J.Cub.2017.12.050  0.812
2018 Brickley SG, Franks NP, Wisden W. Modulation of GABA A receptor function and sleep Current Opinion in Physiology. 2: 51-57. DOI: 10.1016/J.Cophys.2017.12.011  0.756
2017 Wisden W, Yu X, Franks NP. GABA Receptors and the Pharmacology of Sleep. Handbook of Experimental Pharmacology. PMID 28993837 DOI: 10.1007/164_2017_56  0.703
2017 Brickley SG, Ye Z, Yu X, Houston CM, Aboukhalil Z, Franks NP, Wisden W. Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits. Frontiers in Cellular Neuroscience. 11: 95. PMID 28420966 DOI: 10.3389/Fncel.2017.00095  0.562
2016 Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W. Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11171-11184. PMID 27807161 DOI: 10.1523/Jneurosci.3714-15.2016  0.84
2015 Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 87: 164-78. PMID 26094607 DOI: 10.1016/J.Neuron.2015.06.003  0.641
2015 Zhang Z, Ferretti V, Güntan ?, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. Nature Neuroscience. 18: 553-61. PMID 25706476 DOI: 10.1038/Nn.3957  0.841
2015 Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W. The role of K₂p channels in anaesthesia and sleep. PflüGers Archiv : European Journal of Physiology. 467: 907-16. PMID 25482669 DOI: 10.1007/S00424-014-1654-4  0.662
2014 Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W. Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture. Current Biology : Cb. 24: 2838-44. PMID 25454592 DOI: 10.1016/J.Cub.2014.10.019  0.778
2014 Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP. Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13326-35. PMID 25274812 DOI: 10.1523/Jneurosci.1519-14.2014  0.738
2014 Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP. Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep. The European Journal of Neuroscience. 40: 2311-9. PMID 24674448 DOI: 10.1111/Ejn.12570  0.68
2012 Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13062-75. PMID 22993424 DOI: 10.1523/Jneurosci.2931-12.2012  0.697
2012 Houston CM, McGee TP, Mackenzie G, Troyano-Cuturi K, Rodriguez PM, Kutsarova E, Diamanti E, Hosie AM, Franks NP, Brickley SG. Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3887-97. PMID 22423109 DOI: 10.1523/Jneurosci.5406-11.2012  0.37
2011 Franks NP, Zecharia AY. Sleep and general anesthesia. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthã©Sie. 58: 139-48. PMID 21170623 DOI: 10.1007/s12630-010-9420-3  0.634
2009 Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP. An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proceedings of the National Academy of Sciences of the United States of America. 106: 17546-51. PMID 19805135 DOI: 10.1073/Pnas.0907228106  0.653
2009 Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2177-87. PMID 19228970 DOI: 10.1523/JNEUROSCI.4997-08.2009  0.574
2008 Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nature Reviews. Neuroscience. 9: 370-86. PMID 18425091 DOI: 10.1038/nrn2372  0.507
2008 Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. The Journal of Comparative Neurology. 508: 648-62. PMID 18383504 DOI: 10.1002/Cne.21685  0.509
2007 Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology. 106: 746-53. PMID 17413912 DOI: 10.1097/01.anes.0000264762.48920.80  0.309
2007 Bright DP, Adham SD, Lemaire LC, Benavides R, Gruss M, Taylor GW, Smith EH, Franks NP. Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel. The Journal of Biological Chemistry. 282: 12038-47. PMID 17311911 DOI: 10.1074/jbc.M700479200  0.756
2006 Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neuroscience Letters. 409: 128-33. PMID 17052852 DOI: 10.1016/j.neulet.2006.09.020  0.309
2006 Nelson LE, Franks NP, Maze M. The mechanistic relationship between NREM sleep and anesthesia Sleep and Sleep Disorders: a Neuropsychopharmacological Approach. 43-52. DOI: 10.1007/0-387-27682-3_6  0.511
2005 Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Annals of Neurology. 58: 182-93. PMID 16049939 DOI: 10.1002/ana.20547  0.307
2004 Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. European Journal of Pharmacology. 502: 87-97. PMID 15464093 DOI: 10.1016/j.ejphar.2004.08.044  0.331
2004 Nelson LE, Franks NP, Maze M. Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Anesthesiology. 100: 1341-2. PMID 15166550 DOI: 10.1097/00000542-200406000-00003  0.594
2004 Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Molecular Pharmacology. 65: 443-52. PMID 14742687 DOI: 10.1124/Mol.65.2.443  0.761
2003 Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 98: 428-36. PMID 12552203 DOI: 10.1097/00000542-200302000-00024  0.547
2002 Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nature Neuroscience. 5: 979-84. PMID 12195434 DOI: 10.1038/Nn913  0.368
2002 Downie DL, Vicente-Agullo F, Campos-Caro A, Bushell TJ, Lieb WR, Franks NP. Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 277: 10367-73. PMID 11741933 DOI: 10.1074/jbc.M107847200  0.324
2002 Ma D, Wilhelm S, Maze M, Franks NP. Neuroprotective and neurotoxic properties of the ‘inert’ gas, xenon Bja: British Journal of Anaesthesia. 89: 739-746. DOI: 10.1093/Bja/89.5.739  0.303
2000 Dickinson R, White I, Lieb WR, Franks NP. Stereoselective loss of righting reflex in rats by isoflurane. Anesthesiology. 93: 837-43. PMID 10969319 DOI: 10.1097/00000542-200009000-00035  0.383
2000 Downie DL, Franks NP, Lieb WR. Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors. Anesthesiology. 93: 774-83. PMID 10969311 DOI: 10.1097/00000542-200009000-00027  0.346
2000 de Sousa SL, Dickinson R, Lieb WR, Franks NP. Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology. 92: 1055-66. PMID 10754626 DOI: 10.1097/00000542-200004000-00024  0.304
1999 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Preparation of barbiturate optical isomers and their effects on GABA(A) receptors. Anesthesiology. 90: 1714-22. PMID 10360871 DOI: 10.1097/00000542-199906000-00029  0.483
1999 Jenkins A, Franks NP, Lieb WR. Effects of temperature and volatile anesthetics on GABA(A) receptors. Anesthesiology. 90: 484-91. PMID 9952156 DOI: 10.1097/00000542-199902000-00024  0.484
1998 Franks NP, Jenkins A, Conti E, Lieb WR, Brick P. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophysical Journal. 75: 2205-11. PMID 9788915 DOI: 10.1016/S0006-3495(98)77664-7  0.442
1998 Lopes CM, Franks NP, Lieb WR. Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones. British Journal of Pharmacology. 125: 309-18. PMID 9786503 DOI: 10.1038/sj.bjp.0702069  0.3
1998 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology. 88: 708-17. PMID 9523815 DOI: 10.1097/00000542-199803000-00022  0.489
1997 Violet JM, Downie DL, Nakisa RC, Lieb WR, Franks NP. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics. Anesthesiology. 86: 866-74. PMID 9105231 DOI: 10.1097/00000542-199704000-00017  0.343
1996 Downie DL, Hall AC, Lieb WR, Franks NP. Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. British Journal of Pharmacology. 118: 493-502. PMID 8762070 DOI: 10.1111/J.1476-5381.1996.Tb15430.X  0.334
1996 Jenkins A, Franks NP, Lieb WR. Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. British Journal of Pharmacology. 117: 1507-15. PMID 8730747 DOI: 10.1111/J.1476-5381.1996.Tb15314.X  0.445
1995 Dickinson R, Lieb WR, Franks NP. The effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptor. British Journal of Pharmacology. 116: 2949-56. PMID 8680729 DOI: 10.1111/J.1476-5381.1995.Tb15949.X  0.333
1995 McKenzie D, Franks NP, Lieb WR. Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. British Journal of Pharmacology. 115: 275-82. PMID 7670729 DOI: 10.1111/J.1476-5381.1995.Tb15874.X  0.31
1994 Hall AC, Lieb WR, Franks NP. Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor. British Journal of Pharmacology. 112: 906-10. PMID 7921619 DOI: 10.1111/J.1476-5381.1994.Tb13166.X  0.301
1991 Franks NP, Lieb WR. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science (New York, N.Y.). 254: 427-30. PMID 1925602 DOI: 10.1126/Science.1925602  0.337
1988 Franks NP, Lieb WR. Volatile general anaesthetics activate a novel neuronal K+ current. Nature. 333: 662-4. PMID 2453807 DOI: 10.1038/333662a0  0.341
1987 Franks NP, Lieb WR. Neuron membranes: anaesthetics on the mind. Nature. 328: 113-4. PMID 3600786 DOI: 10.1038/328113a0  0.302
1982 Franks NP, Melchior V, Kirshner DA, Caspar DL. Structure of myelin lipid bilayers. Changes during maturation. Journal of Molecular Biology. 155: 133-53. PMID 7077673 DOI: 10.1016/0022-2836(82)90441-7  0.497
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