David Bredt - Publications

Affiliations: 
Eli Lilly and Co., Basingstoke, England, United Kingdom 
Area:
Neurotransmitters

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kweon HJ, Gu S, Witham E, Dhara M, Yu H, Mandon ED, Jawhari A, Bredt DS. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Cell Reports. 32: 108025. PMID 32783947 DOI: 10.1016/J.Celrep.2020.108025  0.359
2020 Dhara M, Matta JA, Lei M, Knowland D, Yu H, Gu S, Bredt DS. Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology. Nature Communications. 11: 2799. PMID 32493979 DOI: 10.1038/S41467-020-16629-3  0.355
2019 Dawe GB, Yu H, Gu S, Blackler AN, Matta JA, Siuda ER, Rex EB, Bredt DS. α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins. Nature Communications. 10: 2746. PMID 31227712 DOI: 10.1038/S41467-019-10723-X  0.386
2019 Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, ... ... Bredt DS, et al. Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 30910921 DOI: 10.1124/Jpet.118.250126  0.306
2019 Gu S, Matta JA, Davini WB, Dawe GB, Lord B, Bredt DS. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Reports. 26: 866-874.e3. PMID 30673609 DOI: 10.1016/j.celrep.2018.12.103  0.304
2017 Maher MP, Matta JA, Gu S, Seierstad M, Bredt DS. Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins. Neuron. 96: 989-1001. PMID 29216460 DOI: 10.1016/j.neuron.2017.10.001  0.301
2016 Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, ... ... Bredt DS, et al. Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine. PMID 27820603 DOI: 10.1038/Nm.4221  0.446
2016 Gardinier KM, Gernert DL, Porter WJ, Reel JK, Ornstein PL, Spinazze P, Stevens FC, Hahn P, Hollinshead SP, Mayhugh D, Schkeryantz J, Khilevich A, De Frutos O, Gleason SD, Kato AS, ... ... Bredt D, et al. The Discovery of The First α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent Upon Transmembrane AMPA Receptor Regulatory Protein (TARP) Gamma-8. Journal of Medicinal Chemistry. PMID 27067148 DOI: 10.1021/Acs.Jmedchem.6B00125  0.453
2016 Erlenhardt N, Yu H, Abiraman K, Yamasaki T, Wadiche JI, Tomita S, Bredt DS. Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission. Cell Reports. PMID 26776514 DOI: 10.1016/J.Celrep.2015.12.078  0.617
2013 Yudowski GA, Olsen O, Adesnik H, Marek KW, Bredt DS. Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses. Plos One. 8: e53965. PMID 23342049 DOI: 10.1371/Journal.Pone.0053965  0.823
2012 Kato AS, Knierman MD, Siuda ER, Isaac JT, Nisenbaum ES, Bredt DS. Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15296-308. PMID 23115168 DOI: 10.1523/Jneurosci.0705-12.2012  0.356
2012 Gill MB, Kato AS, Wang H, Bredt DS. AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. The European Journal of Neuroscience. 35: 182-94. PMID 22211840 DOI: 10.1111/J.1460-9568.2011.07948.X  0.684
2011 Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S. PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity. Nature Neuroscience. 14: 1410-2. PMID 22002768 DOI: 10.1038/Nn.2952  0.766
2011 Gill MB, Kato AS, Roberts MF, Yu H, Wang H, Tomita S, Bredt DS. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6928-38. PMID 21543622 DOI: 10.1523/Jneurosci.6271-10.2011  0.755
2011 Schober DA, Gill MB, Yu H, Gernert DL, Jeffries MW, Ornstein PL, Kato AS, Felder CC, Bredt DS. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. The Journal of Biological Chemistry. 286: 13134-42. PMID 21343286 DOI: 10.1074/Jbc.M110.212522  0.711
2011 Gill MB, Bredt DS. An emerging role for TARPs in neuropsychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 362-3. PMID 21116256 DOI: 10.1038/Npp.2010.149  0.574
2011 Kato A, Gill M, Roberts M, Tomita S, Bredt D. Cornichon-2 dictates physical and pharmacological properties of AMPA receptors by controlling AMPA receptor-TARP assembly Neuroscience Research. 71: e93. DOI: 10.1016/J.Neures.2011.07.400  0.7
2010 Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 68: 1082-96. PMID 21172611 DOI: 10.1016/J.Neuron.2010.11.026  0.764
2010 Kato AS, Gill MB, Yu H, Nisenbaum ES, Bredt DS. TARPs differentially decorate AMPA receptors to specify neuropharmacology. Trends in Neurosciences. 33: 241-8. PMID 20219255 DOI: 10.1016/J.Tins.2010.02.004  0.721
2010 Bredt D, Kato AS, Gill MB. AMPA receptor auxiliary subunits to specify neuropharmacology and synapticplasticity Neuroscience Research. 68: e10. DOI: 10.1016/J.Neures.2010.07.274  0.658
2008 Kato AS, Siuda ER, Nisenbaum ES, Bredt DS. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Neuron. 59: 986-96. PMID 18817736 DOI: 10.1016/J.Neuron.2008.07.034  0.33
2008 Menuz K, O'Brien JL, Karmizadegan S, Bredt DS, Nicoll RA. TARP redundancy is critical for maintaining AMPA receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8740-6. PMID 18753375 DOI: 10.1523/JNEUROSCI.1319-08.2008  0.576
2008 Srinivasan K, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK. MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex. Development (Cambridge, England). 135: 1781-90. PMID 18403412 DOI: 10.1242/Dev.013847  0.561
2008 Bredt DS, Nicoll RA. Alaa El-Din El-Husseini (1962–2007) Visionary Neurobiologist and Revered Mentor Neuron. 57: 498-499. DOI: 10.1016/j.neuron.2008.02.010  0.475
2007 Tomita S, Byrd RK, Rouach N, Bellone C, Venegas A, O'Brien JL, Kim KS, Olsen O, Nicoll RA, Bredt DS. AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 104: 18784-8. PMID 18000041 DOI: 10.1073/Pnas.0708970104  0.766
2007 Olsen O, Funke L, Long JF, Fukata M, Kazuta T, Trinidad JC, Moore KA, Misawa H, Welling PA, Burlingame AL, Zhang M, Bredt DS. Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. The Journal of Cell Biology. 179: 151-64. PMID 17923534 DOI: 10.1083/Jcb.200702054  0.548
2007 Milstein AD, Zhou W, Karimzadegan S, Bredt DS, Nicoll RA. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron. 55: 905-18. PMID 17880894 DOI: 10.1016/j.neuron.2007.08.022  0.583
2007 Kato AS, Zhou W, Milstein AD, Knierman MD, Siuda ER, Dotzlaf JE, Yu H, Hale JE, Nisenbaum ES, Nicoll RA, Bredt DS. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4969-77. PMID 17475805 DOI: 10.1523/Jneurosci.5561-06.2007  0.629
2007 Tomita S, Shenoy A, Fukata Y, Nicoll RA, Bredt DS. Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology. 52: 87-91. PMID 16919685 DOI: 10.1016/j.neuropharm.2006.07.012  0.662
2007 Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA. Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins (DOI:10.1016/j.neuron.2006.09.012) Neuron. 53: 465. DOI: 10.1016/j.neuron.2007.01.007  0.554
2006 Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA. Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron. 52: 307-20. PMID 17046693 DOI: 10.1016/J.Neuron.2006.09.012  0.551
2006 Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (New York, N.Y.). 313: 1792-5. PMID 16990550 DOI: 10.1126/science.1129947  0.519
2006 Tomita S, Sekiguchi M, Wada K, Nicoll RA, Bredt DS. Stargazin controls the pharmacology of AMPA receptor potentiators. Proceedings of the National Academy of Sciences of the United States of America. 103: 10064-7. PMID 16785437 DOI: 10.1073/pnas.0603128103  0.646
2006 Nicoll RA, Tomita S, Bredt DS. Auxiliary subunits assist AMPA-type glutamate receptors. Science (New York, N.Y.). 311: 1253-6. PMID 16513974 DOI: 10.1126/science.1123339  0.659
2006 Olsen O, Moore KA, Nicoll RA, Bredt DS. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Current Opinion in Cell Biology. 18: 223-7. PMID 16504495 DOI: 10.1016/J.Ceb.2006.02.010  0.682
2005 Rouach N, Byrd K, Petralia RS, Elias GM, Adesnik H, Tomita S, Karimzadegan S, Kealey C, Bredt DS, Nicoll RA. TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nature Neuroscience. 8: 1525-33. PMID 16222232 DOI: 10.1038/nn1551  0.675
2005 Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. The Journal of Cell Biology. 170: 1127-34. PMID 16186258 DOI: 10.1083/Jcb.200503011  0.704
2005 Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS. Molecular constituents of neuronal AMPA receptors. The Journal of Cell Biology. 169: 399-404. PMID 15883194 DOI: 10.1083/Jcb.200501121  0.559
2005 Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature. 435: 1052-8. PMID 15858532 DOI: 10.1038/Nature03624  0.673
2005 Kato A, Rouach N, Nicoll RA, Bredt DS. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 102: 5600-5. PMID 15809437 DOI: 10.1073/Pnas.0501769102  0.56
2005 Vandenberghe W, Nicoll RA, Bredt DS. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1095-102. PMID 15689545 DOI: 10.1523/JNEUROSCI.3568-04.2005  0.575
2005 Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 45: 269-77. PMID 15664178 DOI: 10.1016/J.Neuron.2005.01.009  0.659
2005 Vandenberghe W, Nicoll RA, Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proceedings of the National Academy of Sciences of the United States of America. 102: 485-90. PMID 15630087 DOI: 10.1073/pnas.0408269102  0.587
2005 Olsen O, Wade JB, Morin N, Bredt DS, Welling PA. Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney. American Journal of Physiology. Renal Physiology. 288: F345-52. PMID 15494546 DOI: 10.1152/Ajprenal.00235.2004  0.583
2004 Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS. Identification of PSD-95 palmitoylating enzymes. Neuron. 44: 987-96. PMID 15603741 DOI: 10.1016/j.neuron.2004.12.005  0.565
2004 Cuadra AE, Kuo SH, Kawasaki Y, Bredt DS, Chetkovich DM. AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7491-502. PMID 15329396 DOI: 10.1523/JNEUROSCI.1255-04.2004  0.582
2004 Xu Y, Zhang B, Hua Z, Johns RA, Bredt DS, Tao YX. Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. Experimental Neurology. 189: 16-24. PMID 15296832 DOI: 10.1016/j.expneurol.2004.05.013  0.326
2004 McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS. Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 42: 89-99. PMID 15066267 DOI: 10.1016/S0896-6273(04)00149-7  0.674
2004 Tomita S, Fukata M, Nicoll RA, Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (New York, N.Y.). 303: 1508-11. PMID 15001777 DOI: 10.1126/science.1090262  0.676
2004 Parker MJ, Zhao S, Bredt DS, Sanes JR, Feng G. PSD93 regulates synaptic stability at neuronal cholinergic synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 378-88. PMID 14724236 DOI: 10.1523/JNEUROSCI.3865-03.2004  0.334
2003 Bredt DS, Nicoll RA. AMPA receptor trafficking at excitatory synapses. Neuron. 40: 361-79. PMID 14556714 DOI: 10.1016/S0896-6273(03)00640-8  0.592
2003 Dakoji S, Tomita S, Karimzadegan S, Nicoll RA, Bredt DS. Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases. Neuropharmacology. 45: 849-56. PMID 14529722 DOI: 10.1016/S0028-3908(03)00267-3  0.655
2003 Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll RA. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Molecular Pharmacology. 64: 703-6. PMID 12920207 DOI: 10.1124/Mol.64.3.703  0.788
2003 Tao YX, Rumbaugh G, Wang GD, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M, Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RA. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6703-12. PMID 12890763 DOI: 10.1523/Jneurosci.23-17-06703.2003  0.337
2003 Stein V, House DR, Bredt DS, Nicoll RA. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5503-6. PMID 12843250 DOI: 10.1523/Jneurosci.23-13-05503.2003  0.518
2003 Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. The Journal of Cell Biology. 161: 805-16. PMID 12771129 DOI: 10.1083/Jcb.200212116  0.672
2003 McGee AW, Bredt DS. Assembly and plasticity of the glutamatergic postsynaptic specialization. Current Opinion in Neurobiology. 13: 111-8. PMID 12593989 DOI: 10.1016/S0959-4388(03)00008-4  0.75
2003 Olsen O, Bredt DS. Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases. The Journal of Biological Chemistry. 278: 6873-8. PMID 12482754 DOI: 10.1074/Jbc.M210165200  0.561
2002 Misawa H, Sherr EH, Lee DJ, Chetkovich DM, Tan A, Schreiner CE, Bredt DS. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10088-93. PMID 12451109 DOI: 10.1523/Jneurosci.22-23-10088.2002  0.557
2002 Klöcker N, Bunn RC, Schnell E, Caruana G, Bernstein A, Nicoll RA, Bredt DS. Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. The European Journal of Neuroscience. 16: 1517-22. PMID 12405965 DOI: 10.1046/J.1460-9568.2002.02228.X  0.547
2002 Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proceedings of the National Academy of Sciences of the United States of America. 99: 13902-7. PMID 12359873 DOI: 10.1073/Pnas.172511199  0.547
2002 Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS. Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6415-25. PMID 12151521 DOI: 10.1523/Jneurosci.22-15-06415.2002  0.582
2002 Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS. Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5791-6. PMID 12122038 DOI: 10.1523/Jneurosci.22-14-05791.2002  0.739
2002 El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 108: 849-63. PMID 11955437 DOI: 10.1016/S0092-8674(02)00683-9  0.578
2001 McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Molecular Cell. 8: 1291-301. PMID 11779504 DOI: 10.1016/S1097-2765(01)00411-7  0.765
2001 Tomita S, Nicoll RA, Bredt DS. PDZ protein interactions regulating glutamate receptor function and plasticity. The Journal of Cell Biology. 153: F19-24. PMID 11381098 DOI: 10.1083/Jcb.153.5.F19  0.669
2001 McGee AW, Topinka JR, Hashimoto K, Petralia RS, Kakizawa S, Kauer FW, Aguilera-Moreno A, Wenthold RJ, Kano M, Bredt DS, Kauer F. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3085-91. PMID 11312293 DOI: 10.1523/Jneurosci.21-09-03085.2001  0.761
2001 Misawa H, Kawasaki Y, Mellor J, Sweeney N, Jo K, Nicoll RA, Bredt DS. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. The Journal of Biological Chemistry. 276: 9264-72. PMID 11104771 DOI: 10.1074/Jbc.M009334200  0.564
2000 Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 408: 936-43. PMID 11140673 DOI: 10.1038/35050030  0.759
2000 Firestein BL, Craven SE, Bredt DS. Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. Neuroreport. 11: 3479-84. PMID 11095503 DOI: 10.1097/00001756-200011090-00016  0.547
2000 El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS. PSD-95 involvement in maturation of excitatory synapses. Science (New York, N.Y.). 290: 1364-8. PMID 11082065 DOI: 10.1126/Science.290.5495.1364  0.814
2000 Lehrer-Graiwer JE, Firestein BL, Bredt DS. Nitric oxide mediated induction of cytochrome c oxidase mRNA and protein in a mouse macrophage cell line. Neuroscience Letters. 288: 107-10. PMID 10876072 DOI: 10.1016/S0304-3940(00)01205-2  0.547
2000 El-Husseini AE, Topinka JR, Lehrer-Graiwer JE, Firestein BL, Craven SE, Aoki C, Bredt DS. Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs. The Journal of Biological Chemistry. 275: 23904-10. PMID 10779526 DOI: 10.1074/Jbc.M909919199  0.715
2000 El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, Bredt DS. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. The Journal of Cell Biology. 148: 159-72. PMID 10629226 DOI: 10.1083/Jcb.148.1.159  0.777
1999 Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS. Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. Neuron. 24: 659-72. PMID 10595517 DOI: 10.1016/S0896-6273(00)81120-4  0.715
1999 Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. The Journal of Biological Chemistry. 274: 27467-73. PMID 10488080 DOI: 10.1074/Jbc.274.39.27467  0.303
1999 McGee AW, Bredt DS. Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. The Journal of Biological Chemistry. 274: 17431-6. PMID 10364172 DOI: 10.1074/Jbc.274.25.17431  0.698
1999 Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ. Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 3926-34. PMID 10234023  0.733
1999 Craven SE, El-Husseini AE, Bredt DS. Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron. 22: 497-509. PMID 10197530 DOI: 10.1016/S0896-6273(00)80705-9  0.606
1999 Firestein BL, Bredt DS. Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M. The Journal of Biological Chemistry. 274: 10545-50. PMID 10187848 DOI: 10.1074/jbc.274.15.10545  0.547
1999 Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 96: 657-62. PMID 9892689 DOI: 10.1073/Pnas.96.2.657  0.384
1998 Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 21: 1453-63. PMID 9883737 DOI: 10.1016/S0896-6273(00)80663-7  0.667
1998 Koulen P, Fletcher EL, Craven SE, Bredt DS, Wässle H. Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10136-49. PMID 9822767 DOI: 10.1523/Jneurosci.18-23-10136.1998  0.304
1998 Firestein BL, Bredt DS. Regulation of sensory neuron precursor proliferation by cyclic GMP-dependent protein kinase. Journal of Neurochemistry. 71: 1846-53. PMID 9798908 DOI: 10.1046/J.1471-4159.1998.71051846.X  0.547
1998 Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8805-13. PMID 9786987 DOI: 10.1523/Jneurosci.18-21-08805.1998  0.725
1997 Xia H, Winokur ST, Kuo WL, Altherr MR, Bredt DS. Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. The Journal of Cell Biology. 139: 507-15. PMID 9334352 DOI: 10.1083/jcb.139.2.507  0.431
1997 Brenman JE, Xia H, Chao DS, Black SM, Bredt DS. Regulation of neuronal nitric oxide synthase through alternative transcripts. Developmental Neuroscience. 19: 224-31. PMID 9208206 DOI: 10.1159/000111211  0.431
1997 Xia H, Fitzgerald J, Bredt DS, Forsayeth JR. Detection of mycoplasma infection of mammalian cells. Biotechniques. 22: 934-6. PMID 9149878 DOI: 10.2144/97225St08  0.431
1997 Chao DS, Silvagno F, Xia H, Cornwell TL, Lincoln TM, Bredt DS. Nitric oxide synthase and cyclic GMP-dependent protein kinase concentrated at the neuromuscular endplate. Neuroscience. 76: 665-72. PMID 9135041 DOI: 10.1016/S0306-4522(96)00367-3  0.5
1996 Brenman JE, Christopherson KS, Craven SE, McGee AW, Bredt DS. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7407-15. PMID 8922396 DOI: 10.1523/Jneurosci.16-23-07407.1996  0.757
1996 Cohen NA, Brenman JE, Snyder SH, Bredt DS. Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron. 17: 759-67. PMID 8893032 DOI: 10.1016/S0896-6273(00)80207-X  0.422
1996 Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochemical Research. 21: 861-8. PMID 8873091 DOI: 10.1007/Bf02532310  0.431
1996 Xia H, Bredt DS. Cloned and expressed nitric oxide synthase proteins. Methods in Enzymology. 268: 427-36. PMID 8782609 DOI: 10.1016/S0076-6879(96)68045-8  0.472
1996 Silvagno F, Xia H, Bredt DS. Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. The Journal of Biological Chemistry. 271: 11204-8. PMID 8626668 DOI: 10.1074/Jbc.271.19.11204  0.431
1996 Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 84: 757-67. PMID 8625413 DOI: 10.1016/S0092-8674(00)81053-3  0.769
1995 Bredt DS, Wang TL, Cohen NA, Guggino WB, Snyder SH. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 92: 6753-7. PMID 7624316 DOI: 10.1073/Pnas.92.15.6753  0.355
1995 Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell. 82: 743-52. PMID 7545544 DOI: 10.1016/0092-8674(95)90471-9  0.431
1995 Burnett AL, Ricker DD, Chamness SL, Maguire MP, Crone JK, Bredt DS, Snyder SH, Chang TS. Localization of nitric oxide synthase in the reproductive organs of the male rat. Biology of Reproduction. 52: 1-7. PMID 7536043 DOI: 10.1095/biolreprod52.1.1  0.33
1994 Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annual Review of Biochemistry. 63: 175-95. PMID 7526779 DOI: 10.1146/annurev.bi.63.070194.001135  0.308
1994 Bredt DS, Snyder SH. Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium. Neuron. 13: 301-13. PMID 7520252 DOI: 10.1016/0896-6273(94)90348-4  0.358
1994 Roskams AJ, Bredt DS, Dawson TM, Ronnett GV. Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons. Neuron. 13: 289-99. PMID 7520251 DOI: 10.1016/0896-6273(94)90347-6  0.463
1994 Saito S, Kidd GJ, Trapp BD, Dawson TM, Bredt DS, Wilson DA, Traystman RJ, Snyder SH, Hanley DF. Rat spinal cord neurons contain nitric oxide synthase. Neuroscience. 59: 447-56. PMID 7516502 DOI: 10.1016/0306-4522(94)90608-4  0.512
1994 Berezin I, Snyder SH, Bredt DS, Daniel EE. Ultrastructural localization of nitric oxide synthase in canine small intestine and colon. The American Journal of Physiology. 266: C981-9. PMID 7513956 DOI: 10.1152/AJPCELL.1994.266.4.C981  0.318
1993 Zhang X, Verge V, Wiesenfeld-Hallin Z, Ju G, Bredt D, Synder SH, Hökfelt T. Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy. The Journal of Comparative Neurology. 335: 563-75. PMID 7693774 DOI: 10.1002/Cne.903350408  0.303
1993 Anderson CR, Edwards SL, Furness JB, Bredt DS, Snyder SH. The distribution of nitric oxide synthase-containing autonomic preganglionic terminals in the rat. Brain Research. 614: 78-85. PMID 7688648 DOI: 10.1016/0006-8993(93)91020-S  0.364
1993 Yamamoto R, Bredt DS, Snyder SH, Stone RA. The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Neuroscience. 54: 189-200. PMID 7685860 DOI: 10.1016/0306-4522(93)90393-T  0.339
1993 Burnett AL, Tillman SL, Chang TS, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. The Journal of Urology. 150: 73-6. PMID 7685426 DOI: 10.1016/S0022-5347(17)35401-0  0.348
1993 Breslow MJ, Tobin JR, Bredt DS, Ferris CD, Snyder SH, Traystman RJ. Nitric oxide as a regulator of adrenal blood flow. The American Journal of Physiology. 264: H464-9. PMID 7680537 DOI: 10.1152/AJPHEART.1993.264.2.H464  0.579
1993 Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 13: 70-9. PMID 7678014 DOI: 10.1038/Jcbfm.1993.9  0.493
1993 Yamamoto R, Bredt DS, Dawson TM, Snyder SH, Stone RA. Enhanced expression of nitric oxide synthase by rat retina following pterygopalatine parasympathetic denervation. Brain Research. 631: 83-8. PMID 7507791 DOI: 10.1016/0006-8993(93)91190-4  0.477
1993 Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 75: 1273-86. PMID 7505721 DOI: 10.1016/0092-8674(93)90615-W  0.526
1993 Hwang P, Fotuhi M, Bredt D, Cunningham A, Snyder S. Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily The Journal of Neuroscience. 13: 1569-1576. DOI: 10.1523/JNEUROSCI.13-04-01569.1993  0.324
1992 Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Neuron. 8: 473-81. PMID 1550672 DOI: 10.1016/0896-6273(92)90275-I  0.621
1992 Ceccatelli S, Lundberg JM, Fahrenkrug J, Bredt DS, Snyder SH, Hökfelt T. Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow. Neuroscience. 51: 769-72. PMID 1488122 DOI: 10.1016/0306-4522(92)90518-7  0.322
1992 Ward SM, Xue C, Shuttleworth CW, Bredt DS, Snyder SH, Sanders KM. NADPH diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon. The American Journal of Physiology. 263: G277-84. PMID 1381151 DOI: 10.1152/Ajpgi.1992.263.2.G277  0.362
1992 Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proceedings of the National Academy of Sciences of the United States of America. 89: 6711-5. PMID 1379716 DOI: 10.1073/Pnas.89.15.6711  0.644
1992 Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science (New York, N.Y.). 257: 401-3. PMID 1378650 DOI: 10.1126/Science.1378650  0.368
1992 Young HM, Furness JB, Shuttleworth CW, Bredt DS, Snyder SH. Co-localization of nitric oxide synthase immunoreactivity and NADPH diaphorase staining in neurons of the guinea-pig intestine. Histochemistry. 97: 375-8. PMID 1377664 DOI: 10.1007/Bf00270041  0.357
1992 Llewellyn-Smith IJ, Song ZM, Costa M, Bredt DS, Snyder SH. Ultrastructural localization of nitric oxide synthase immunoreactivity in guinea-pig enteric neurons. Brain Research. 577: 337-42. PMID 1376636 DOI: 10.1016/0006-8993(92)90294-J  0.375
1992 Breslow MJ, Tobin JR, Bredt DS, Ferris CD, Snyder SH, Traystman RJ. Role of nitric oxide in adrenal medullary vasodilation during catecholamine secretion. European Journal of Pharmacology. 210: 105-6. PMID 1376270 DOI: 10.1016/0014-2999(92)90659-R  0.59
1992 Bredt DS, Ferris CD, Snyder SH. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. The Journal of Biological Chemistry. 267: 10976-81. PMID 1375933  0.575
1992 Snyder SH, Bredt DS. Biological roles of nitric oxide. Scientific American. 266: 68-71, 74-7. PMID 1373517 DOI: 10.1038/SCIENTIFICAMERICAN0592-68  0.318
1992 Bredt DS, Snyder SH. Nitric oxide, a novel neuronal messenger. Neuron. 8: 3-11. PMID 1370373 DOI: 10.1016/0896-6273(92)90104-L  0.356
1992 Ferris CD, Cameron AM, Bredt DS, Huganir RL, Snyder SH. Autophosphorylation of inositol 1,4,5-trisphosphate receptors. The Journal of Biological Chemistry. 267: 7036-41. PMID 1313030  0.61
1992 Costa M, Furness JB, Pompolo S, Brookes SJ, Bornstein JC, Bredt DS, Snyder SH. Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neuroscience Letters. 148: 121-5. PMID 1284439 DOI: 10.1016/0304-3940(92)90819-S  0.342
1992 Hyman BT, Marzloff K, Wenniger JJ, Dawson TM, Bredt DS, Snyder SH. Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. Annals of Neurology. 32: 818-20. PMID 1281971 DOI: 10.1002/Ana.410320618  0.54
1992 McMillan K, Bredt DS, Hirsch DJ, Snyder SH, Clark JE, Masters BS. Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America. 89: 11141-5. PMID 1280819 DOI: 10.1073/PNAS.89.23.11141  0.358
1991 Ferris CD, Huganir RL, Bredt DS, Cameron AM, Snyder SH. Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles. Proceedings of the National Academy of Sciences of the United States of America. 88: 2232-5. PMID 1848697 DOI: 10.1073/PNAS.88.6.2232  0.629
1991 Ferris CD, Cameron AM, Bredt DS, Huganir RL, Snyder SH. Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589. Biochemical and Biophysical Research Communications. 175: 192-8. PMID 1847804 DOI: 10.1016/S0006-291X(05)81219-7  0.622
1991 Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 7: 615-24. PMID 1718335 DOI: 10.1016/0896-6273(91)90374-9  0.701
1991 Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proceedings of the National Academy of Sciences of the United States of America. 88: 7797-801. PMID 1715581 DOI: 10.1073/Pnas.88.17.7797  0.526
1991 Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends in Pharmacological Sciences. 12: 125-8. PMID 1712138 DOI: 10.1016/0165-6147(91)90526-X  0.355
1991 Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 351: 714-8. PMID 1712077 DOI: 10.1016/0962-8924(91)90032-5  0.648
1991 Dwyer MA, Bredt DS, Snyder SH. Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochemical and Biophysical Research Communications. 176: 1136-41. PMID 1710109 DOI: 10.1016/0006-291X(91)90403-T  0.329
1991 Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 88: 6368-71. PMID 1648740 DOI: 10.1073/Pnas.88.14.6368  0.528
1991 Bredt D, Hwang P, Glatt C, Lowenstein C, Reed R, Snyder S. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase Trends in Cell Biology. 1: 86. DOI: 10.1016/0962-8924(91)90032-5  0.628
1990 Hwang PM, Verma A, Bredt DS, Snyder SH. Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction. Proceedings of the National Academy of Sciences of the United States of America. 87: 7395-9. PMID 2217172 DOI: 10.1073/PNAS.87.19.7395  0.346
1990 Hwang PM, Bredt DS, Snyder SH. Autoradiographic imaging of phosphoinositide turnover in the brain. Science (New York, N.Y.). 249: 802-4. PMID 1975122 DOI: 10.1126/SCIENCE.1975122  0.335
1990 Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 347: 768-70. PMID 1700301 DOI: 10.1038/347768a0  0.351
1990 Ross CA, Bredt D, Snyder SH. Messenger molecules in the cerebellum. Trends in Neurosciences. 13: 216-22. PMID 1694327 DOI: 10.1016/0166-2236(90)90163-5  0.631
1990 Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proceedings of the National Academy of Sciences of the United States of America. 87: 682-5. PMID 1689048 DOI: 10.1073/PNAS.87.2.682  0.331
1989 Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 86: 9030-3. PMID 2573074 DOI: 10.1073/pnas.86.22.9030  0.358
1989 Bredt DS, Mourey RJ, Snyder SH. A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues. Biochemical and Biophysical Research Communications. 159: 976-82. PMID 2539157 DOI: 10.1016/0006-291X(89)92204-3  0.312
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