Richard A. Young - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
gene control
Website:
https://biology.mit.edu/people/richard_young

343 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ma H, Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, ... Young RA, et al. The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Cell Stem Cell. 29: 1611. PMID 36332573 DOI: 10.1016/j.stem.2022.10.003  0.377
2022 Morelli E, Fulciniti M, Samur MK, Ribeiro C, Wert-Lamas L, Henninger JE, Gulla A, Aktas Samur A, Todoerti K, Talluri S, Park WD, Federico C, Scionti F, Amodio N, Bianchi G, ... ... Young R, et al. A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth. Blood. PMID 36126301 DOI: 10.1182/blood.2022016892  0.523
2022 Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, ... Young RA, et al. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nature Communications. 13: 4345. PMID 35896549 DOI: 10.1038/s41467-022-31541-8  0.501
2022 Banani SF, Afeyan LK, Hawken SW, Henninger JE, Dall'Agnese A, Clark VE, Platt JM, Oksuz O, Hannett NM, Sagi I, Lee TI, Young RA. Genetic variation associated with condensate dysregulation in disease. Developmental Cell. PMID 35809564 DOI: 10.1016/j.devcel.2022.06.010  0.773
2022 Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, ... Young RA, et al. The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Cell Stem Cell. PMID 35452598 DOI: 10.1016/j.stem.2022.03.015  0.498
2021 Reddy J, Fonseca MAS, Corona RI, Nameki R, Segato Dezem F, Klein IA, Chang H, Chaves-Moreira D, Afeyan LK, Malta TM, Lin X, Abbasi F, Font-Tello A, Sabedot T, Cejas P, ... ... Young RA, et al. Predicting master transcription factors from pan-cancer expression data. Science Advances. 7: eabf6123. PMID 34818047 DOI: 10.1126/sciadv.abf6123  0.794
2021 Zhang L, Richards A, Barrasa MI, Hughes SH, Young RA, Jaenisch R. Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34702742 DOI: 10.1073/pnas.2114995118  0.378
2021 Zhang L, Richards A, Barrasa MI, Hughes SH, Young RA, Jaenisch R. Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34344760 DOI: 10.1073/pnas.2109497118  0.356
2021 Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, ... ... Young RA, et al. STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell. 39: 827-844.e10. PMID 34129824 DOI: 10.1016/j.ccell.2021.05.007  0.317
2021 Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, ... ... Young RA, et al. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372: 716-721. PMID 33986176 DOI: 10.1126/science.aaz2740  0.321
2021 Zhang L, Richards A, Barrasa MI, Hughes SH, Young RA, Jaenisch R. Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33958444 DOI: 10.1073/pnas.2105968118  0.439
2021 Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, ... ... Young RA, et al. Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity. Cell Reports. Medicine. 2: 100188. PMID 33521702 DOI: 10.1016/j.xcrm.2020.100188  0.571
2020 Henninger JE, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng MM, Andrews JO, Zamudio AV, Lazaris C, Hannett NM, Lee TI, Sharp PA, Cissé II, Chakraborty AK, Young RA. RNA-Mediated Feedback Control of Transcriptional Condensates. Cell. PMID 33333019 DOI: 10.1016/j.cell.2020.11.030  0.803
2020 Zhang L, Richards A, Khalil A, Wogram E, Ma H, Young RA, Jaenisch R. SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome. Biorxiv : the Preprint Server For Biology. PMID 33330870 DOI: 10.1101/2020.12.12.422516  0.454
2020 Choudhuri A, Trompouki E, Abraham BJ, Colli LM, Kock KH, Mallard W, Yang ML, Vinjamur DS, Ghamari A, Sporrij A, Hoi K, Hummel B, Boatman S, Chan V, Tseng S, ... ... Young RA, et al. Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nature Genetics. PMID 33230299 DOI: 10.1038/s41588-020-00738-2  0.325
2020 Daneshvar K, Ardehali MB, Klein IA, Hsieh FK, Kratkiewicz AJ, Mahpour A, Cancelliere SOL, Zhou C, Cook BM, Li W, Pondick JV, Gupta SK, Moran SP, Young RA, Kingston RE, et al. lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nature Cell Biology. PMID 32895492 DOI: 10.1038/S41556-020-0572-2  0.83
2020 Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, ... ... Young RA, et al. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32883883 DOI: 10.1073/Pnas.2003228117  0.497
2020 Li CH, Coffey EL, Dall'Agnese A, Hannett NM, Tang X, Henninger JE, Platt JM, Oksuz O, Zamudio AV, Afeyan LK, Schuijers J, Liu XS, Markoulaki S, Lungjangwa T, LeRoy G, ... ... Young RA, et al. MeCP2 links heterochromatin condensates and neurodevelopmental disease. Nature. PMID 32698189 DOI: 10.1038/S41586-020-2574-4  0.784
2020 Sabari BR, Dall'Agnese A, Young RA. Biomolecular Condensates in the Nucleus. Trends in Biochemical Sciences. PMID 32684431 DOI: 10.1016/j.tibs.2020.06.007  0.783
2020 Tao T, Shi H, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601179 DOI: 10.1073/Pnas.1922692117  0.519
2020 Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, ... ... Young RA, et al. Partitioning of cancer therapeutics in nuclear condensates. Science (New York, N.Y.). 368: 1386-1392. PMID 32554597 DOI: 10.1126/Science.Aaz4427  0.758
2020 Michowski W, Chick JM, Chu C, Kolodziejczyk A, Wang Y, Suski JM, Abraham B, Anders L, Day D, Dunkl LM, Li Cheong Man M, Zhang T, Laphanuwat P, Bacon NA, Liu L, ... ... Young RA, et al. Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells. Molecular Cell. PMID 32240602 DOI: 10.1016/J.Molcel.2020.03.010  0.431
2020 Yao Y, Park WD, Morelli E, Samur MK, Kwiatkowski NP, Xu Y, Chakraborty C, Nabet B, Chesi M, Avet-Loiseau H, Gray N, Young RA, Anderson K, Lin CY, Munshi NC, et al. Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition Blood. 136: 1-2. DOI: 10.1182/blood-2020-142592  0.302
2020 Morelli E, Fulciniti M, Samur MK, Ribeiro C, Wert-Lamas L, Gulla A, Aktas-Samur A, Todoerti K, Talluri S, Park WD, Henninger JE, Federico C, Bianchi G, Scionti F, Yao Y, ... ... Young RA, et al. RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma Blood. 136: 20-21. DOI: 10.1182/blood-2020-142514  0.358
2020 Durbin AD, Wimalasena V, Zimmerman MW, Deyao L, Frank ES, Park P, Morita K, Dharia NV, Ross KN, Schonbrunn E, Young RA, Abraham BJ, Stegmaier K, Look AT, Qi J. Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Pr11  0.415
2020 Zimmerman MW, Durbin AD, Abraham BJ, Berezovskaya A, He S, Oppel F, Young RA, Look AT. Abstract B22: Cell state and lineage specification are controlled by epigenetic landscapes regulating the core transcriptional regulatory circuitry in pediatric neuroblastoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B22  0.539
2020 Durbin AD, Kugener G, Zimmerman MW, Yan C, Dharia NV, Frank ES, Chen X, Ross KN, Paolella B, Krill-Burger M, Root DE, Boehm JS, Vazquez F, Hong AL, Tsherniak A, ... ... Young RA, et al. Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B10  0.441
2019 Wang L, Tan TK, Durbin AD, Zimmerman MW, Abraham BJ, Tan SH, Ngoc PCT, Weichert-Leahey N, Akahane K, Lawton LN, Rokita JL, Maris JM, Young RA, Look AT, Sanda T. ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. Nature Communications. 10: 5622. PMID 31819055 DOI: 10.1038/S41467-019-13515-5  0.519
2019 Zamudio AV, Dall'Agnese A, Henninger JE, Manteiga JC, Afeyan LK, Hannett NM, Coffey EL, Li CH, Oksuz O, Sabari BR, Boija A, Klein IA, Hawken SW, Spille JH, Decker TM, ... ... Young RA, et al. Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes. Molecular Cell. PMID 31563432 DOI: 10.1016/J.Molcel.2019.08.016  0.814
2019 Song Y, van den Berg PR, Markoulaki S, Soldner F, Dall'Agnese A, Henninger JE, Drotar J, Rosenau N, Cohen MA, Young RA, Semrau S, Stelzer Y, Jaenisch R. Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Molecular Cell. PMID 31422875 DOI: 10.1016/J.Molcel.2019.06.045  0.524
2019 Shrinivas K, Sabari BR, Coffey EL, Klein IA, Boija A, Zamudio AV, Schuijers J, Hannett NM, Sharp PA, Young RA, Chakraborty AK. Enhancer Features that Drive Formation of Transcriptional Condensates. Molecular Cell. 75: 549-561.e7. PMID 31398323 DOI: 10.1016/J.Molcel.2019.07.009  0.823
2019 Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, ... ... Young RA, et al. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates. Nature. PMID 31391587 DOI: 10.1038/S41586-019-1464-0  0.793
2019 Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, ... ... Young RA, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. PMID 31391581 DOI: 10.1038/S41586-019-1472-0  0.473
2019 Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, ... ... Young RA, et al. CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation. Nature Communications. 10: 1757. PMID 30988284 DOI: 10.1038/S41467-019-09703-Y  0.445
2019 Rossmann MP, Hoi K, Chan V, Perlin JR, Hagedorn EJ, Abraham BJ, Yang S, Sullivan LB, Warren CR, Vyas S, Custo-Creig E, Dorjsuren B, Cowan C, Haigis MC, Young RA, et al. Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis Blood. 134: 152-152. DOI: 10.1182/Blood-2019-126833  0.427
2019 Abraham BJ, Reddy J, Fonseca MA, Klein IA, Afeyan LK, Corona RI, Cejas P, Segato F, Karlan BY, Gayther SA, Freedman ML, Noushmehr H, Brown M, Matulonis UA, Lawrenson K, ... Young RA, et al. Abstract 2615: Systematic approaches to predict oncogenic transcriptional regulatory circuitries identify important nodes in high-grade serous ovarian cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2615  0.316
2018 Fulciniti M, Lin CY, Samur MK, Lopez MA, Singh I, Lawlor MA, Szalat RE, Ott CJ, Avet-Loiseau H, Anderson KC, Young RA, Bradner JE, Munshi NC. Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma. Cell Reports. 25: 3693-3705.e6. PMID 30590042 DOI: 10.1016/j.celrep.2018.12.016  0.662
2018 Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, ... ... Young RA, et al. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell. PMID 30449618 DOI: 10.1016/J.Cell.2018.10.042  0.8
2018 Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. PMID 30209401 DOI: 10.1038/S41586-018-0487-2  0.768
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature Genetics. PMID 30127528 DOI: 10.1038/S41588-018-0191-Z  0.495
2018 Mansour MR, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, ... ... Young RA, et al. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of Experimental Medicine. PMID 29941549 DOI: 10.1084/Jem.20170484  0.333
2018 Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, ... ... Young RA, et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science (New York, N.Y.). PMID 29930091 DOI: 10.1126/Science.Aar3958  0.823
2018 Schuijers J, Manteiga JC, Weintraub AS, Day DS, Zamudio AV, Hnisz D, Lee TI, Young RA. Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism. Cell Reports. 23: 349-360. PMID 29641996 DOI: 10.1016/j.celrep.2018.03.056  0.832
2018 Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, ... ... Young RA, et al. Cross-cohort analysis identifies a TEAD4 ↔ MYCN positive-feedback loop as the core regulatory element of high-risk neuroblastoma. Cancer Discovery. PMID 29510988 DOI: 10.1158/2159-8290.Cd-16-0861  0.407
2018 Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. PMID 29456084 DOI: 10.1016/J.Cell.2018.01.012  0.492
2018 Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. BET bromodomain proteins regulate enhancer function during adipogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29444854 DOI: 10.1073/Pnas.1711155115  0.634
2018 Eliades P, Abraham BJ, Ji Z, Miller DM, Christensen CL, Kwiatkowski N, Kumar R, Njauw CN, Taylor M, Miao B, Zhang T, Wong KK, Gray NS, Young RA, Tsao H. High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma. The Journal of Investigative Dermatology. PMID 29408204 DOI: 10.1016/J.Jid.2017.09.056  0.394
2018 Iniguez AB, Stolte B, Wang EJ, Conway AS, Alexe G, Dharia NV, Kwiatkowski N, Zhang T, Abraham BJ, Mora J, Kalev P, Leggett A, Chowdhury D, Benes CH, Young RA, et al. EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. Cancer Cell. PMID 29358035 DOI: 10.1016/J.Ccell.2017.12.009  0.363
2018 Ott CJ, Szalat R, Lawlor M, Samur MK, Xu Y, Epstein CB, Lin CY, Prabhala R, Farrell N, Walter LD, Schwartz L, Wen K, Tai Y, Fulciniti M, Wang J, ... ... Young RA, et al. Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma Blood. 132: 1313-1313. DOI: 10.1182/Blood-2018-99-119941  0.476
2018 Choudhuri A, Trompouki E, Abraham BJ, Colli L, Mallard W, Yang M, Vinjamur D, Ghamari A, Nandakumar S, Hoi K, Hummel B, Boatman S, Chan V, Bowman TV, Yang S, ... ... Young RA, et al. Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits Blood. 132: 1277-1277. DOI: 10.1182/Blood-2018-99-118637  0.45
2018 Tothova Z, Krill-Burger JM, Day DS, Haydu JE, Abraham BJ, Landers CC, Malolepsza E, Hartigan CR, Holmes A, Donahue M, Popova KD, Koochaki S, Rivera J, Seiler M, Hnisz D, ... ... Young RA, et al. STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia Blood. 132: 940-940. DOI: 10.1182/Blood-2018-99-117480  0.388
2018 Chakraborty C, Samur MK, Young RA, Anderson K, Lin CY, Fulciniti M, Munshi N. Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma Blood. 132: 3156-3156. DOI: 10.1182/BLOOD-2018-99-112583  0.513
2018 Dharia NV, Malone C, Iniguez AB, Guenther L, Chen L, Alexe G, Durbin AD, Zimmerman MW, Hong A, Bandopadhayay P, Filbin MG, Howard T, Paolella B, Fung I, Lee J, ... ... Young RA, et al. Abstract 2352: Defining a pediatric cancer dependency map Cancer Research. 78: 2352-2352. DOI: 10.1158/1538-7445.Am2018-2352  0.37
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Balboni-Iniguez A, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry Cancer Research. 78: 2062-2062. DOI: 10.1158/1538-7445.Am2018-2062  0.517
2017 Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT. c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification. Cancer Discovery. PMID 29284669 DOI: 10.1158/2159-8290.Cd-17-0993  0.358
2017 Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature Chemical Biology. PMID 29251720 DOI: 10.1038/Nchembio.2538  0.322
2017 Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, ... Young RA, et al. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Cell. 171: 1573-1588.e28. PMID 29224777 DOI: 10.1016/J.Cell.2017.11.008  0.819
2017 Rusan M, Li K, Li Y, Christensen CL, Abraham BJ, Kwiatkowski N, Buczkowski KA, Bockorny B, Chen T, Li S, Rhee K, Zhang H, Chen W, Terai H, Tavares T, ... ... Young RA, et al. Suppression of adaptive responses to targeted cancer therapy by transcriptional repression. Cancer Discovery. PMID 29054992 DOI: 10.1158/2159-8290.Cd-17-0461  0.334
2017 Kalan S, Amat R, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Reports. 21: 467-481. PMID 29020632 DOI: 10.1016/J.Celrep.2017.09.056  0.372
2017 Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, ... ... Young RA, et al. TOX regulates growth, DNA repair, and genomic instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discovery. PMID 28974511 DOI: 10.1158/2159-8290.Cd-17-0267  0.344
2017 Hnisz D, Young RA. New Insights into Genome Structure: Genes of a Feather Stick Together. Molecular Cell. 67: 730-731. PMID 28886334 DOI: 10.1016/j.molcel.2017.08.023  0.355
2017 Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Science Translational Medicine. 9. PMID 28637928 DOI: 10.1126/scitranslmed.aai9118  0.305
2017 Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sánchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & Development. PMID 28607179 DOI: 10.1101/Gad.295857.117  0.507
2017 Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A Phase Separation Model for Transcriptional Control. Cell. 169: 13-23. PMID 28340338 DOI: 10.1016/J.Cell.2017.02.007  0.403
2017 Suzuki HI, Young RA, Sharp PA. Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell. 168: 1000-1014.e15. PMID 28283057 DOI: 10.1016/j.cell.2017.02.015  0.304
2017 Rahman S, Magnussen M, León TE, Farah N, Li Z, Abraham BJ, Alapi KZ, Mitchell RJ, Naughton T, Fielding AK, Pizzey A, Bustraan S, Allen C, Popa T, Pike-Overzet K, ... ... Young RA, et al. Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood. PMID 28270453 DOI: 10.1182/blood-2016-09-742148  0.371
2017 Li Z, Abraham BJ, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan SH, Sanda T, Weintraub AS, Li B, Shen S, Zhang J, Mansour MR, Young RA, et al. APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia. PMID 28260788 DOI: 10.1038/leu.2017.75  0.392
2017 Harmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, ... ... Young RA, et al. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications. 8: 14433. PMID 28195122 DOI: 10.1038/Ncomms14433  0.376
2017 Bradner JE, Hnisz D, Young RA. Transcriptional Addiction in Cancer. Cell. 168: 629-643. PMID 28187285 DOI: 10.1016/j.cell.2016.12.013  0.385
2017 Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, ... ... Young RA, et al. Small genomic insertions form enhancers that misregulate oncogenes. Nature Communications. 8: 14385. PMID 28181482 DOI: 10.1038/Ncomms14385  0.347
2017 Lin CY, Fulciniti M, Lopez MA, Samur MK, Szalat R, Ott CJ, Epstein C, Young RA, Bradner J, Anderson KC, Munshi N. Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC Blood. 130: 64-64. DOI: 10.1182/Blood.V130.Suppl_1.64.64  0.5
2017 Fulciniti M, Lin CY, Samur MK, Young R, Avet-loiseau H, Anderson K, Bradner J, Munshi N. Abstract 5490: Non-overlapping promoter and super-enhancer-associated dependencies in multiple myeloma Cancer Research. 77: 5490-5490. DOI: 10.1158/1538-7445.Am2017-5490  0.514
2017 Rusan M, Li K, Li Y, Christensen CL, Abraham BJ, Kwiatkowski N, Buczkowski K, Bockorny B, Chen T, Li S, Zhang H, Terai H, Tavares T, Zhang T, Kim TJ, ... ... Young RA, et al. Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition Cancer Research. 77: 15-15. DOI: 10.1158/1538-7445.Am2017-15  0.31
2017 Balboni AL, Stolte B, Conway AS, Alexe G, Wang EJ, Kwiatkowski N, Zhang T, Abraham BJ, Kalev P, Chowdhury D, Benes CH, Young RA, Gray NS, Stegmaier K. Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements Cancer Research. 77: 1118-1118. DOI: 10.1158/1538-7445.Am2017-1118  0.337
2016 Hnisz D, Day DS, Young RA. Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Cell. 167: 1188-1200. PMID 27863240 DOI: 10.1016/j.cell.2016.10.024  0.471
2016 Witt AE, Lee CW, Lee TI, Azzam DJ, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick EB, Gropper AB, Wahlestedt C, Richardson AL, Shiekhattar R, Young RA, et al. Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene. PMID 27694895 DOI: 10.1038/Onc.2016.337  0.358
2016 Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, Shu J, Dadon D, Young RA, Jaenisch R. Editing DNA Methylation in the Mammalian Genome. Cell. 167: 233-247.e17. PMID 27662091 DOI: 10.1016/J.Cell.2016.08.056  0.527
2016 Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, ... ... Young RA, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nature Chemical Biology. PMID 27571479 DOI: 10.1038/Nchembio.2166  0.431
2016 Clark VE, Harmancı AS, Bai H, Youngblood MW, Lee TI, Baranoski JF, Ercan-Sencicek AG, Abraham BJ, Weintraub AS, Hnisz D, Simon M, Krischek B, Erson-Omay EZ, Henegariu O, Carrión-Grant G, ... ... Young RA, et al. Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nature Genetics. PMID 27548314 DOI: 10.1038/Ng.3651  0.389
2016 Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & Development. PMID 27492367 DOI: 10.1101/Gad.282756.116  0.796
2016 Soldner F, Stelzer Y, Shivalila CS, Abraham BJ, Latourelle JC, Barrasa MI, Goldmann J, Myers RH, Young RA, Jaenisch R. Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature. PMID 27096366 DOI: 10.1038/Nature17939  0.575
2016 Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, ... ... Young RA, et al. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell. 62: 34-46. PMID 27058786 DOI: 10.1016/J.Molcel.2016.03.013  0.561
2016 Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, ... ... Young RA, et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science (New York, N.Y.). PMID 26940867 DOI: 10.1126/Science.Aad9024  0.793
2016 Saint-André V, Federation AJ, Lin CY, Abraham BJ, Reddy J, Lee TI, Bradner JE, Young RA. Models of human core transcriptional regulatory circuitries. Genome Research. PMID 26843070 DOI: 10.1101/Gr.197590.115  0.836
2016 Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, ... ... Young RA, et al. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science (New York, N.Y.). 351: aad2197. PMID 26823433 DOI: 10.1126/Science.Aad2197  0.367
2016 Heyn H, Vidal E, Ferreira HJ, Vizoso M, Sayols S, Gomez A, Moran S, Boque-Sastre R, Guil S, Martinez-Cardus A, Lin CY, Royo R, Sanchez-Mut JV, Martinez R, Gut M, ... ... Young RA, et al. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer. Genome Biology. 17: 11. PMID 26813288 DOI: 10.1186/S13059-016-0879-2  0.535
2016 Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Jin Huh S, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, ... ... Young RA, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. PMID 26735014 DOI: 10.1038/Nature16508  0.522
2016 Rahman S, Magnussen M, León TE, Farah N, Abraham BJ, Li Z, Alapi KZ, Mitchell RJ, Naughton T, Fielding AK, Pizzey A, Bustraan S, Allen C, Gale RE, Linch DC, ... Young RA, et al. Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter Blood. 128: 733-733. DOI: 10.1182/blood.V128.22.733.733  0.381
2016 Guo YE, Young R. Abstract A166: Biogenesis and regulatory functions of super-enhancer RNAs in cancer cells of the immune system Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A166  0.434
2016 Guo YE, Seyffert M, Abraham B, Ji X, Young R. Abstract B121: Oncogenic MYC contributes to tumor super-enhancers via eRNA amplification Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B121  0.454
2016 Kaufman CK, Mosimann C, Thomas A, Fan ZP, Yang S, Tan J, Fogley RD, Rooijen Ev, Hagedorn E, Ciarlo C, White R, Matos D, Puller A, Santoriello C, Liao E, ... Young RA, et al. Abstract PR06: The reemergence of neural crest progenitor identity is a key event in the initiation of melanoma from a field of cancer-prone melanocytes Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Pr06  0.383
2016 Schuijers J, Day DS, Saint-Andre V, Young RA. Abstract PR01: 3D enhancer clusters in the response to Wnt-driven colorectal cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Pr01  0.354
2016 Shu S, Lin C, He HH, Witwicki R, Roberts J, Tabassum D, Liang Y, Ekram M, Doherty E, Brown J, Mohammed H, D'Santos C, McKeown M, Ott C, Qi J, ... ... Young R, et al. Abstract B16: Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-B16  0.393
2016 Krajewska M, Moore NF, Chipumuro E, Zhang T, Marco E, Hatheway C, Sharma B, Kwiatkowski N, Yuan G, Young RA, Gray NS, George RE. Abstract PR04: Targeting super-enhancer driven oncogene transcription through cyclin-dependent kinase inhibitors Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Pr04  0.46
2016 Soto-Feliciano YM, Bartlebaugh JM, Liu Y, Sánchez-Rivera FJ, Weintraub AS, Bhutkar A, Jacks TE, Young RA, Hemann MT. Abstract A44: The role of PHF6 in maintaining pre-B cell commitment in B-cell acute lymphoblastic leukemia Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-A44  0.396
2016 Lobbardi R, Pinder J, Martinez-Pastor B, Blackburn J, Abraham BJ, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, Waard Md, Jain E, Bhere D, Shah K, Gutierrez A, ... ... Young RA, et al. Abstract 3583: Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia Cancer Research. 76: 3583-3583. DOI: 10.1158/1538-7445.Am2016-3583  0.377
2016 Balboni A, Stolte B, Kalev P, Kwiatkowski N, Zhang T, Abraham B, Alexe G, Chowdhury D, Young RA, Gray NS, Stegmaier K. Abstract 2441: CDK12/13 inhibition cooperates with the Ewing sarcoma oncoprotein EWS/FLI to attenuate homologous recombination repair in Ewing sarcoma cells Cancer Research. 76: 2441-2441. DOI: 10.1158/1538-7445.Am2016-2441  0.422
2016 Sanda T, Akahanse K, Abraham BJ, Weichert N, Durbin A, Anders L, Tan SH, Yam AWY, Lawton LN, Young RA, Maris JM, Look AT. Abstract 2007: Transcriptional regulatory program controlled by the oncogenic transcription factor LMO1 in neuroblastoma Cancer Research. 76: 2007-2007. DOI: 10.1158/1538-7445.Am2016-2007  0.482
2016 Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Rahman S, Li Z, Lee TI, Look AT, Mansour M, Young RA. Abstract 2004: Nucleation of transcriptional super-enhancers at tumor oncogenes by small insertions Cancer Research. 76: 2004-2004. DOI: 10.1158/1538-7445.Am2016-2004  0.396
2015 Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA. 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell. PMID 26686465 DOI: 10.1016/J.Stem.2015.11.007  0.57
2015 D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA. A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity. Stem Cell Reports. PMID 26603904 DOI: 10.1016/J.Stemcr.2015.09.016  0.6
2015 Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, ... ... Young RA, et al. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature. PMID 26560027 DOI: 10.1038/Nature15540  0.365
2015 Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Transcription factor trapping by RNA in gene regulatory elements. Science (New York, N.Y.). PMID 26516199 DOI: 10.1126/science.aad3346  0.823
2015 Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 163: 174-186. PMID 26406377 DOI: 10.1016/J.Cell.2015.08.063  0.406
2015 Tan SH, Yam AW, Lawton LN, Wong RW, Young RA, Look AT, Sanda T. TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia. Leukemia. PMID 26202930 DOI: 10.1038/leu.2015.195  0.337
2015 Hnisz D, Schuijers J, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA. Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Molecular Cell. 58: 362-70. PMID 25801169 DOI: 10.1016/j.molcel.2015.02.014  0.613
2015 Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proceedings of the National Academy of Sciences of the United States of America. 112: 3841-6. PMID 25755260 DOI: 10.1073/Pnas.1502971112  0.528
2015 Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes & Development. 29: 483-8. PMID 25737277 DOI: 10.1101/Gad.254151.114  0.418
2015 Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, Zhang T, Hatheway CM, Abraham BJ, Sharma B, Yeung C, Altabef A, Perez-Atayde A, Wong K, Yuan G, Gray NS, Young RA, et al. Abstract PR05: Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-Pr05  0.397
2015 Zhang X, Francis J, Lin C, Rahl P, Bradner J, Young R. Abstract A38: The role of MGA loss-of-function mutations in lung adenocarcinomas Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A38  0.323
2015 Abraham BJ, Kwiatkowski N, Weintraub AS, Hnisz D, Hannett N, Young RA. Abstract PR14: Nucleation of transcriptional super-enhancers at tumor oncogenes Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr14  0.402
2015 Abraham BJ, Kwiatkowski N, Weintraub AS, Hnisz D, Hannett N, Young RA. Abstract PR06: Nucleation of transcriptional super-enhancers at tumor oncogenes Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr06  0.401
2015 Christensen C, Kwiatkowski N, Abraham B, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie G, Akbay E, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel J, Cavanaugh J, ... ... Young R, et al. Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor Cancer Cell. 27: 149. DOI: 10.1016/J.Ccell.2014.12.007  0.322
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell. 15: 524-526. PMID 28903030 DOI: 10.1016/j.stem.2014.09.003  0.768
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell. 15: 523. PMID 28903029 DOI: 10.1016/J.Stem.2014.08.002  0.767
2014 Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel JB, Cavanaugh JD, ... ... Young RA, et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell. 26: 909-22. PMID 25490451 DOI: 10.1016/J.Ccell.2014.10.019  0.415
2014 Cassady JP, D'Alessio AC, Sarkar S, Dani VS, Fan ZP, Ganz K, Roessler R, Sur M, Young RA, Jaenisch R. Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells. Stem Cell Reports. 3: 948-56. PMID 25454632 DOI: 10.1016/J.Stemcr.2014.10.001  0.556
2014 Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, Zhang T, Hatheway CM, Abraham BJ, Sharma B, Yeung C, Altabef A, Perez-Atayde A, Wong KK, Yuan GC, Gray NS, Young RA, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell. 159: 1126-39. PMID 25416950 DOI: 10.1016/J.Cell.2014.10.024  0.434
2014 Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science (New York, N.Y.). 346: 1373-7. PMID 25394790 DOI: 10.1126/Science.1259037  0.448
2014 Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schuijers J, Lee TI, Zhao K, Young RA. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 159: 374-87. PMID 25303531 DOI: 10.1016/J.Cell.2014.09.030  0.834
2014 Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham BJ, Porubsky D, Kulenkampff E, Faddah DA, Shi L, Gao Q, Sarkar S, ... ... Young RA, et al. The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell. 15: 295-309. PMID 25192464 DOI: 10.1016/J.Stem.2014.07.003  0.803
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 15: 471-87. PMID 25090446 DOI: 10.1016/J.Stem.2014.07.002  0.8
2014 Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, ... ... Young RA, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 511: 616-20. PMID 25043025 DOI: 10.1038/Nature13393  0.825
2014 Dowen JM, Young RA. SMC complexes link gene expression and genome architecture. Current Opinion in Genetics & Development. 25: 131-7. PMID 24794701 DOI: 10.1016/J.Gde.2013.11.009  0.823
2014 Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, ... ... Young RA, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 40: 477-89. PMID 24745332 DOI: 10.1016/J.Immuni.2014.04.004  0.667
2014 Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, ... ... Young RA, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 6: 313-24. PMID 24440720 DOI: 10.1016/J.Celrep.2013.12.032  0.489
2014 Rahl PB, Young RA. MYC and transcription elongation. Cold Spring Harbor Perspectives in Medicine. 4: a020990. PMID 24384817 DOI: 10.1101/cshperspect.a020990  0.514
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Genome-wide localization of small molecules. Nature Biotechnology. 32: 92-6. PMID 24336317 DOI: 10.1038/Nbt.2776  0.793
2014 Chipumuro E, Marco E, Zhang T, Christensen C, Kwiatkowski N, Sharma B, Hatheway C, Altabef A, Abraham BJ, Wong K, Yuan G, Young RA, Gray NS, George RE. Abstract LB-125: Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-125  0.433
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Abstract 3230: Genome-wide localization of anti-cancer drugs Cancer Research. 74: 3230-3230. DOI: 10.1158/1538-7445.Am2014-3230  0.699
2014 Theunissen T, Powell B, Wang H, Mitalipova M, Faddah D, Reddy J, Fan Z, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young R, et al. Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (DOI:10.1016/j.stem.2014.07.002) Cell Stem Cell. DOI: 10.1016/j.stem.2014.08.002  0.371
2014 Choudhuri A, Abraham B, Mallard W, Hummel B, Boatman S, Bowman T, DiBiase A, Rinn J, Young R, Zon L, Trompouki E. Lineage regulators and signaling transcription factors during erythropoiesis Experimental Hematology. 42: S63. DOI: 10.1016/J.Exphem.2014.07.239  0.404
2013 Chapuy B, McKeown MR, Lin CY, Monti S, Roemer MG, Qi J, Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E, Kung AL, Rodig SJ, Young RA, Shipp MA, et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. Cancer Cell. 24: 777-90. PMID 24332044 DOI: 10.1016/J.Ccr.2013.11.003  0.552
2013 Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 1: 371-8. PMID 24286025 DOI: 10.1016/J.Stemcr.2013.09.002  0.833
2013 Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Young RA, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/Gad.232710.113  0.507
2013 Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 155: 934-47. PMID 24119843 DOI: 10.1016/j.cell.2013.09.053  0.827
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, ... Young RA, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/J.Stem.2013.09.001  0.532
2013 Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 16061-6. PMID 24043772 DOI: 10.1073/Pnas.1315204110  0.412
2013 Mazzoni EO, Mahony S, Peljto M, Patel T, Thornton SR, McCuine S, Reeder C, Boyer LA, Young RA, Gifford DK, Wichterle H. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nature Neuroscience. 16: 1191-8. PMID 23955559 DOI: 10.1038/Nn.3490  0.688
2013 Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. The Journal of Experimental Medicine. 210: 1545-57. PMID 23857984 DOI: 10.1084/Jem.20122516  0.333
2013 Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, D'Alessio AC, Young RA, Weinberg RA. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell. 154: 61-74. PMID 23827675 DOI: 10.1016/J.Cell.2013.06.005  0.629
2013 Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA. Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes & Development. 27: 941-54. PMID 23630078 DOI: 10.1101/Gad.215376.113  0.396
2013 Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/J.Cell.2013.03.036  0.816
2013 Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 153: 307-19. PMID 23582322 DOI: 10.1016/J.Cell.2013.03.035  0.67
2013 Lee TI, Young RA. Transcriptional regulation and its misregulation in disease. Cell. 152: 1237-51. PMID 23498934 DOI: 10.1016/j.cell.2013.02.014  0.474
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/Pnas.1221904110  0.84
2013 Young RA. Control of the Stem Cell Gene Expression Program Blood. 122: SCI-46-SCI-46. DOI: 10.1182/BLOOD.V122.21.SCI-46.SCI-46  0.459
2013 Chapuy B, Michael M, Lin CY, Monti S, Roemer MG, Qi J, Rahl PB, Sun H, Yeda KT, Kung AL, Rodig SJ, Young RA, Shipp MA, Bradner JE. Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma Blood. 122: 3021-3021. DOI: 10.1182/Blood.V122.21.3021.3021  0.53
2013 Young RA. Abstract IA01: Transcriptional and epigenetic control of oncogenes Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-Ia01  0.435
2012 Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA. Revisiting global gene expression analysis. Cell. 151: 476-82. PMID 23101621 DOI: 10.1016/J.Cell.2012.10.012  0.811
2012 Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 151: 56-67. PMID 23021215 DOI: 10.1016/J.Cell.2012.08.026  0.624
2012 Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 22: 209-21. PMID 22897851 DOI: 10.1016/J.Ccr.2012.06.007  0.419
2012 Welstead GG, Creyghton MP, Bilodeau S, Cheng AW, Markoulaki S, Young RA, Jaenisch R. X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 109: 13004-9. PMID 22826230 DOI: 10.1073/Pnas.1210787109  0.516
2012 Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/J.Ygeno.2012.07.006  0.737
2012 Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 11: 319-32. PMID 22770845 DOI: 10.1016/J.Stem.2012.06.002  0.453
2012 Guenther MG, Young RA. Grounded: transcriptional pausing in naive mESCs. Cell Stem Cell. 10: 484-5. PMID 22560069 DOI: 10.1016/J.Stem.2012.04.016  0.713
2012 Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Developmental Cell. 22: 625-38. PMID 22421047 DOI: 10.1016/J.Devcel.2012.01.003  0.482
2012 Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. 482: 221-5. PMID 22297846 DOI: 10.1038/Nature10805  0.83
2012 Cheng B, Li T, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH. Functional association of Gdown1 with RNA polymerase II poised on human genes. Molecular Cell. 45: 38-50. PMID 22244331 DOI: 10.1016/J.Molcel.2011.10.022  0.407
2012 Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 535-40. PMID 22203960 DOI: 10.1073/Pnas.1119351109  0.469
2012 Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina C, von Boehmer H, Young R, Look AT. The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia Blood. 120: 1296-1296. DOI: 10.1182/Blood.V120.21.1296.1296  0.3
2011 Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H. Embryonic stem cell-based mapping of developmental transcriptional programs. Nature Methods. 8: 1056-8. PMID 22081127 DOI: 10.1038/Nmeth.1775  0.471
2011 Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, ... ... Young RA, et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 147: 577-89. PMID 22036566 DOI: 10.1182/Blood.V118.21.3387.3387  0.446
2011 Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/J.Cell.2011.08.050  0.818
2011 Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, ... ... Young RA, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/J.Cell.2011.08.017  0.431
2011 Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. Plos One. 6: e22416. PMID 21886766 DOI: 10.1371/Journal.Pone.0022416  0.765
2011 Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell. 9: 219-32. PMID 21885018 DOI: 10.1016/J.Stem.2011.07.015  0.424
2011 Wong P, Hattangadi SM, Cheng AW, Frampton GM, Young RA, Lodish HF. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood. 118: e128-38. PMID 21860024 DOI: 10.1182/Blood-2011-03-341404  0.467
2011 Wang J, Kumar RM, Biggs VJ, Lee H, Chen Y, Kagey MH, Young RA, Abate-Shen C. The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. Developmental Cell. 21: 575-88. PMID 21852201 DOI: 10.1016/J.Devcel.2011.07.003  0.497
2011 White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, ... ... Young RA, et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471: 518-22. PMID 21430780 DOI: 10.1038/Nature09882  0.566
2011 Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, ... ... Young RA, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471: 513-7. PMID 21430779 DOI: 10.1038/Nature09806  0.412
2011 Young RA. Control of the embryonic stem cell state. Cell. 144: 940-54. PMID 21414485 DOI: 10.1016/j.cell.2011.01.032  0.412
2011 Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, ... ... Young RA, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 144: 296-309. PMID 21241896 DOI: 10.1016/J.Cell.2011.01.004  0.485
2011 Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK. Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Genome Biology. 12: R2. PMID 21232103 DOI: 10.1186/Gb-2011-12-1-R2  0.386
2011 Sanda T, Lawton LN, Barrasa MI, Fan ZP, Ahn Y, Young R, Look AT. Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia, Blood. 118: 3453-3453. DOI: 10.1182/Blood.V118.21.3453.3453  0.481
2011 Issa GC, Delmore JE, McKeown MR, Lemieux ME, Rahl PB, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Shi J, Chesi M, Schinzel AC, Vakoc CR, Bergsagel P, ... ... Young R, et al. Inhibition of c-Myc Expression and Function in Hematologic Malignancies Blood. 118: 1409-1409. DOI: 10.1182/Blood.V118.21.1409.1409  0.359
2011 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, Van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture (Nature (2010) 467 (430-435)) Nature. 472: 247. DOI: 10.1038/Nature09930  0.695
2011 Mullen AC, Newman JJ, Orlando DA, Young RA. Oct4 Directs TGF-Beta Signaling in Embryonic Stem Cells Gastroenterology. 140: S-321. DOI: 10.1016/S0016-5085(11)61300-0  0.689
2010 Newman JJ, Young RA. Connecting transcriptional control to chromosome structure and human disease. Cold Spring Harbor Symposia On Quantitative Biology. 75: 227-35. PMID 21209391 DOI: 10.1101/sqb.2010.75.016  0.512
2010 Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proceedings of the National Academy of Sciences of the United States of America. 107: 21931-6. PMID 21106759 DOI: 10.1073/Pnas.1016071107  0.778
2010 Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 67: 781-96. PMID 20826310 DOI: 10.1016/J.Neuron.2010.08.008  0.323
2010 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 467: 430-5. PMID 20720539 DOI: 10.1038/nature09380  0.822
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/J.Stem.2010.06.015  0.786
2010 Guenther MG, Young RA. Transcription. Repressive transcription. Science (New York, N.Y.). 329: 150-1. PMID 20616255 DOI: 10.1126/Science.1193995  0.747
2010 Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes & Development. 24: 1479-84. PMID 20581084 DOI: 10.1101/Gad.1935210  0.734
2010 Kanhere A, Viiri K, Araújo CC, Rasaiyaah J, Bouwman RD, Whyte WA, Pereira CF, Brookes E, Walker K, Bell GW, Pombo A, Fisher AG, Young RA, Jenner RG. Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Molecular Cell. 38: 675-88. PMID 20542000 DOI: 10.1016/j.molcel.2010.03.019  0.484
2010 Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 141: 872-83. PMID 20471072 DOI: 10.1016/J.Cell.2010.04.010  0.741
2010 Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA. c-Myc regulates transcriptional pause release. Cell. 141: 432-45. PMID 20434984 DOI: 10.1016/J.Cell.2010.03.030  0.639
2010 Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 463: 374-8. PMID 20090754 DOI: 10.1038/Nature08684  0.788
2010 Trompouki E, Bowman TV, Lawton LN, Fan ZP, DiBiase A, Cech J, Sessa A, LeBlanc J, Li P, Heffner G, Daley GQ, Young R, Zon LI. BMP and WNT-Directed Transcription Factors TCF7L2/TCF4 and SMAD1 Bind to Distinct Hematopoietic-Specific Target Genes Depending on Cell Lineage Blood. 116: 3870-3870. DOI: 10.1182/Blood.V116.21.3870.3870  0.487
2010 Mullen AC, Newman JJ, Kumar RM, Orlando DA, Young RA. 786 TGF-β Signaling is Directed to the Targets of Master Transcription Factors Gastroenterology. 138: S-110-S-111. DOI: 10.1016/S0016-5085(10)60507-0  0.706
2009 Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA. SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes & Development. 23: 2484-9. PMID 19884255 DOI: 10.1101/gad.1837309  0.495
2009 Juan AH, Kumar RM, Marx JG, Young RA, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Molecular Cell. 36: 61-74. PMID 19818710 DOI: 10.1016/J.Molcel.2009.08.008  0.371
2009 Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proceedings of the National Academy of Sciences of the United States of America. 106: 17876-81. PMID 19805038 DOI: 10.1073/Pnas.0909357106  0.407
2008 Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes & Development. 22: 3403-8. PMID 19141473 DOI: 10.1101/Gad.1741408  0.817
2008 Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Divergent transcription from active promoters. Science (New York, N.Y.). 322: 1849-51. PMID 19056940 DOI: 10.1126/Science.1162253  0.696
2008 Cole MF, Young RA. Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harbor Symposia On Quantitative Biology. 73: 183-93. PMID 19022761 DOI: 10.1101/Sqb.2008.73.027  0.501
2008 Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, Young RA, Jaenisch R, Boyer LA. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell. 135: 649-61. PMID 18992931 DOI: 10.1016/J.Cell.2008.09.056  0.844
2008 Lopez-Bigas N, Kisiel TA, Dewaal DC, Holmes KB, Volkert TL, Gupta S, Love J, Murray HL, Young RA, Benevolenskaya EV. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Molecular Cell. 31: 520-30. PMID 18722178 DOI: 10.1016/j.molcel.2008.08.004  0.504
2008 Burkhardt BR, Cook JR, Young RA, Wolf BA. PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter. Biochimica Et Biophysica Acta. 1779: 645-51. PMID 18708173 DOI: 10.1016/J.Bbagrm.2008.07.007  0.353
2008 Mathur D, Danford TW, Boyer LA, Young RA, Gifford DK, Jaenisch R. Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET. Genome Biology. 9: R126. PMID 18700969 DOI: 10.1186/Gb-2008-9-8-R126  0.77
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, ... ... Young RA, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/J.Cell.2008.07.020  0.799
2008 Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell. 3: 132-5. PMID 18682236 DOI: 10.1016/J.Stem.2008.06.019  0.662
2008 Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes & Development. 22: 746-55. PMID 18347094 DOI: 10.1101/Gad.1642408  0.83
2008 Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 132: 567-82. PMID 18295576 DOI: 10.1016/J.Cell.2008.01.015  0.53
2007 Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nature Genetics. 39: 1512-6. PMID 17994019 DOI: 10.1038/Ng.2007.26  0.747
2007 Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. Plos One. 2: e1061. PMID 17957245 DOI: 10.1371/Journal.Pone.0001061  0.476
2007 Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell. 130: 77-88. PMID 17632057 DOI: 10.1016/J.Cell.2007.05.042  0.851
2007 Zeitlinger J, Zinzen RP, Stark A, Kellis M, Zhang H, Young RA, Levine M. Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes & Development. 21: 385-90. PMID 17322397 DOI: 10.1101/Gad.1509607  0.729
2007 Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 445: 931-5. PMID 17237765 DOI: 10.1038/Nature05478  0.771
2007 Palomero T, Wei KL, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, et al. Erratum: NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth (Proceedings of the National Academy of Sciences of the United States of America (2006) 103, 48, (18261-18266) DOI: 10.1073/pnas.0606108103) Proceedings of the National Academy of Sciences of the United States of America. 104. DOI: 10.1073/Pnas.0700840104  0.369
2006 Lee TI, Johnstone SE, Young RA. Chromatin immunoprecipitation and microarray-based analysis of protein location. Nature Protocols. 1: 729-48. PMID 17406303 DOI: 10.1038/nprot.2006.98  0.775
2006 Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proceedings of the National Academy of Sciences of the United States of America. 103: 18261-6. PMID 17114293 DOI: 10.1073/Pnas.0606108103  0.452
2006 Qi Y, Rolfe A, MacIsaac KD, Gerber GK, Pokholok D, Zeitlinger J, Danford T, Dowell RD, Fraenkel E, Jaakkola TS, Young RA, Gifford DK. High-resolution computational models of genome binding events. Nature Biotechnology. 24: 963-70. PMID 16900145 DOI: 10.1038/Nbt1233  0.74
2006 Wardle FC, Odom DT, Bell GW, Yuan B, Danford TW, Wiellette EL, Herbolsheimer E, Sive HL, Young RA, Smith JC. Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biology. 7: R71. PMID 16889661 DOI: 10.1186/Gb-2006-7-8-R71  0.436
2006 Pokholok DK, Zeitlinger J, Hannett NM, Reynolds DB, Young RA. Activated signal transduction kinases frequently occupy target genes. Science (New York, N.Y.). 313: 533-6. PMID 16873666 DOI: 10.1126/science.1127677  0.733
2006 Odom DT, Dowell RD, Jacobsen ES, Nekludova L, Rolfe PA, Danford TW, Gifford DK, Fraenkel E, Bell GI, Young RA. Core transcriptional regulatory circuitry in human hepatocytes. Molecular Systems Biology. 2: 2006.0017. PMID 16738562 DOI: 10.1038/Msb4100059  0.494
2006 Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, ... ... Young RA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 125: 301-13. PMID 16630818 DOI: 10.1016/J.Cell.2006.02.043  0.835
2006 Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 441: 349-53. PMID 16625203 DOI: 10.1038/Nature04733  0.846
2006 Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood. 108: 986-92. PMID 16621969 DOI: 10.1182/Blood-2005-08-3482  0.448
2006 Schreiber J, Jenner RG, Murray HL, Gerber GK, Gifford DK, Young RA. Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 103: 5899-904. PMID 16595631 DOI: 10.1073/pnas.0510996103  0.435
2006 Keshet I, Schlesinger Y, Farkash S, Rand E, Hecht M, Segal E, Pikarski E, Young RA, Niveleau A, Cedar H, Simon I. Evidence for an instructive mechanism of de novo methylation in cancer cells. Nature Genetics. 38: 149-53. PMID 16444255 DOI: 10.1038/Ng1719  0.392
2006 Cao Y, Kumar RM, Penn BH, Berkes CA, Kooperberg C, Boyer LA, Young RA, Tapscott SJ. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. The Embo Journal. 25: 502-11. PMID 16437161 DOI: 10.1038/Sj.Emboj.7600958  0.744
2006 Macisaac KD, Gordon DB, Nekludova L, Odom DT, Schreiber J, Gifford DK, Young RA, Fraenkel E. A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data. Bioinformatics (Oxford, England). 22: 423-9. PMID 16332710 DOI: 10.1093/Bioinformatics/Bti815  0.361
2005 Kiburz BM, Reynolds DB, Megee PC, Marston AL, Lee BH, Lee TI, Levine SS, Young RA, Amon A. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes & Development. 19: 3017-30. PMID 16357219 DOI: 10.1101/Gad.1373005  0.625
2005 Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122: 947-56. PMID 16153702 DOI: 10.1016/J.Cell.2005.08.020  0.838
2005 Balciunaite E, Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Molecular and Cellular Biology. 25: 8166-78. PMID 16135806 DOI: 10.1128/Mcb.25.18.8166-8178.2005  0.453
2005 Pokholok DK, Harbison CT, Levine S, Cole M, Hannett NM, Lee TI, Bell GW, Walker K, Rolfe PA, Herbolsheimer E, Zeitlinger J, Lewitter F, Gifford DK, Young RA. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell. 122: 517-27. PMID 16122420 DOI: 10.1016/J.Cell.2005.06.026  0.819
2005 Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Molecular Cell. 18: 623-35. PMID 15949438 DOI: 10.1016/J.Molcel.2005.05.012  0.476
2005 Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA. Global and Hox-specific roles for the MLL1 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 8603-8. PMID 15941828 DOI: 10.1073/Pnas.0503072102  0.765
2005 Jenner RG, Young RA. Insights into host responses against pathogens from transcriptional profiling. Nature Reviews. Microbiology. 3: 281-94. PMID 15806094 DOI: 10.1038/nrmicro1126  0.418
2005 Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, ... Young RA, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proceedings of the National Academy of Sciences of the United States of America. 102: 4459-64. PMID 15753290 DOI: 10.1073/Pnas.0501076102  0.622
2004 Mukherjee S, Berger MF, Jona G, Wang XS, Muzzey D, Snyder M, Young RA, Bulyk ML. Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nature Genetics. 36: 1331-9. PMID 15543148 DOI: 10.1038/Ng1473  0.508
2004 Cam H, Balciunaite E, Blais A, Spektor A, Scarpulla RC, Young R, Kluger Y, Dynlacht BD. A common set of gene regulatory networks links metabolism and growth inhibition. Molecular Cell. 16: 399-411. PMID 15525513 DOI: 10.1016/J.Molcel.2004.09.037  0.448
2004 Robert F, Pokholok DK, Hannett NM, Rinaldi NJ, Chandy M, Rolfe A, Workman JL, Gifford DK, Young RA. Global position and recruitment of HATs and HDACs in the yeast genome. Molecular Cell. 16: 199-209. PMID 15494307 DOI: 10.1016/J.Molcel.2004.09.021  0.824
2004 Harbison CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J, Jennings EG, Zeitlinger J, Pokholok DK, Kellis M, Rolfe PA, ... ... Young RA, et al. Transcriptional regulatory code of a eukaryotic genome. Nature. 431: 99-104. PMID 15343339 DOI: 10.1038/Nature02800  0.815
2004 Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science (New York, N.Y.). 303: 1378-81. PMID 14988562 DOI: 10.1126/Science.1089769  0.835
2004 Palomero T, Odom DT, O’Neil J, Ferrando AA, Winter SS, Larson RS, Young RA, Look AT. Genome-Wide Transcriptional Regulatory Networks Downstream of TAL1/SCL in T-Cell Acute Lymphoblastic Leukemia. Blood. 104: 416-416. DOI: 10.1182/Blood.V104.11.416.416  0.472
2003 Bar-Joseph Z, Gerber GK, Lee TI, Rinaldi NJ, Yoo JY, Robert F, Gordon DB, Fraenkel E, Jaakkola TS, Young RA, Gifford DK. Computational discovery of gene modules and regulatory networks. Nature Biotechnology. 21: 1337-42. PMID 14555958 DOI: 10.1038/Nbt890  0.82
2003 Dror RO, Murnick JG, Rinaldi NJ, Marinescu VD, Rifkin RM, Young RA. Bayesian estimation of transcript levels using a general model of array measurement noise. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 10: 433-52. PMID 12935337 DOI: 10.1089/10665270360688110  0.778
2003 Shen WC, Bhaumik SR, Causton HC, Simon I, Zhu X, Jennings EG, Wang TH, Young RA, Green MR. Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. The Embo Journal. 22: 3395-402. PMID 12840001 DOI: 10.1093/Emboj/Cdg336  0.827
2003 Nau GJ, Schlesinger A, Richmond JF, Young RA. Cumulative Toll-like receptor activation in human macrophages treated with whole bacteria. Journal of Immunology (Baltimore, Md. : 1950). 170: 5203-9. PMID 12734368 DOI: 10.4049/Jimmunol.170.10.5203  0.792
2003 Zeitlinger J, Simon I, Harbison CT, Hannett NM, Volkert TL, Fink GR, Young RA. Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell. 113: 395-404. PMID 12732146 DOI: 10.1016/S0092-8674(03)00301-5  0.757
2003 Ng HH, Robert F, Young RA, Struhl K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Molecular Cell. 11: 709-19. PMID 12667453 DOI: 10.1016/S1097-2765(03)00092-3  0.696
2003 Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nature Medicine. 9: 191-7. PMID 12539042 DOI: 10.1038/nm822  0.321
2002 Ansari AZ, Koh SS, Zaman Z, Bongards C, Lehming N, Young RA, Ptashne M. Transcriptional activating regions target a cyclin-dependent kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 14706-9. PMID 12417740 DOI: 10.1073/Pnas.232573899  0.578
2002 Lee TI, Rinaldi NJ, Robert F, Odom DT, Bar-Joseph Z, Gerber GK, Hannett NM, Harbison CT, Thompson CM, Simon I, Zeitlinger J, Jennings EG, Murray HL, Gordon DB, Ren B, ... ... Young RA, et al. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (New York, N.Y.). 298: 799-804. PMID 12399584 DOI: 10.1126/Science.1075090  0.804
2002 Stanojevic D, Young RA. A highly potent artificial transcription factor. Biochemistry. 41: 7209-16. PMID 12044151 DOI: 10.1021/bi015906b  0.475
2002 Pokholok DK, Hannett NM, Young RA. Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Molecular Cell. 9: 799-809. PMID 11983171 DOI: 10.1016/S1097-2765(02)00502-6  0.43
2002 Ng HH, Robert F, Young RA, Struhl K. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes & Development. 16: 806-19. PMID 11937489 DOI: 10.1101/Gad.978902  0.751
2002 Damelin M, Simon I, Moy TI, Wilson B, Komili S, Tempst P, Roth FP, Young RA, Cairns BR, Silver PA. The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Molecular Cell. 9: 563-73. PMID 11931764 DOI: 10.1016/S1097-2765(02)00475-6  0.424
2002 Wyrick JJ, Young RA. Deciphering gene expression regulatory networks. Current Opinion in Genetics & Development. 12: 130-6. PMID 11893484 DOI: 10.1016/S0959-437X(02)00277-0  0.697
2002 Nau GJ, Richmond JF, Schlesinger A, Jennings EG, Lander ES, Young RA. Human macrophage activation programs induced by bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 99: 1503-8. PMID 11805289 DOI: 10.1073/Pnas.022649799  0.785
2002 Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes & Development. 16: 245-56. PMID 11799067 DOI: 10.1101/Gad.949802  0.611
2001 Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP, Aparicio OM. Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (New York, N.Y.). 294: 2357-60. PMID 11743203 DOI: 10.1126/Science.1066101  0.653
2001 Virbasius CM, Holstege FC, Young RA, Green MR. Promoter-specific activation defects by a novel yeast TBP mutant compromised for TFIIB interaction. Current Biology : Cb. 11: 1794-8. PMID 11719223 DOI: 10.1016/S0960-9822(01)00566-8  0.449
2001 Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science (New York, N.Y.). 294: 870-5. PMID 11679675 DOI: 10.1126/Science.294.5543.870  0.323
2001 Simon I, Barnett J, Hannett N, Harbison CT, Rinaldi NJ, Volkert TL, Wyrick JJ, Zeitlinger J, Gifford DK, Jaakkola TS, Young RA. Serial regulation of transcriptional regulators in the yeast cell cycle. Cell. 106: 697-708. PMID 11572776 DOI: 10.1016/S0092-8674(01)00494-9  0.728
2001 Wilson CJ, Guglielmo C, Moua ND, Tudor M, Grosveld G, Young RA, Murray PJ. Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. Analytical Biochemistry. 296: 270-8. PMID 11554723 DOI: 10.1006/abio.2001.5304  0.339
2001 Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS, Carr SA, Deshaies RJ. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes & Development. 15: 1078-92. PMID 11331604 DOI: 10.1101/Gad.867501  0.474
2001 Geisberg JV, Holstege FC, Young RA, Struhl K. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Molecular and Cellular Biology. 21: 2736-42. PMID 11283253 DOI: 10.1128/Mcb.21.8.2736-2742.2001  0.618
2001 Zaman Z, Ansari AZ, Koh SS, Young R, Ptashne M. Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression. Proceedings of the National Academy of Sciences of the United States of America. 98: 2550-4. PMID 11226276 DOI: 10.1073/Pnas.041611198  0.606
2001 Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA. Remodeling of yeast genome expression in response to environmental changes. Molecular Biology of the Cell. 12: 323-37. PMID 11179418 DOI: 10.1091/Mbc.12.2.323  0.539
2000 Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA. Genome-wide location and function of DNA binding proteins. Science (New York, N.Y.). 290: 2306-9. PMID 11125145 DOI: 10.1126/science.290.5500.2306  0.739
2000 Lee TI, Young RA. Transcription of eukaryotic protein-coding genes. Annual Review of Genetics. 34: 77-137. PMID 11092823 DOI: 10.1146/annurev.genet.34.1.77  0.483
2000 Lee TI, Causton HC, Holstege FC, Shen WC, Hannett N, Jennings EG, Winston F, Green MR, Young RA. Redundant roles for the TFIID and SAGA complexes in global transcription. Nature. 405: 701-4. PMID 10864329 DOI: 10.1038/35015104  0.453
2000 Robertson LS, Causton HC, Young RA, Fink GR. The yeast A kinases differentially regulate iron uptake and respiratory function. Proceedings of the National Academy of Sciences of the United States of America. 97: 5984-8. PMID 10811893 DOI: 10.1073/Pnas.100113397  0.357
1999 Wyrick JJ, Holstege FC, Jennings EG, Causton HC, Shore D, Grunstein M, Lander ES, Young RA. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature. 402: 418-21. PMID 10586882 DOI: 10.1038/46567  0.722
1999 Tudor M, Murray PJ, Onufryk C, Jaenisch R, Young RA. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes & Development. 13: 2365-8. PMID 10500093 DOI: 10.1101/Gad.13.18.2365  0.581
1999 Kobor MS, Archambault J, Lester W, Holstege FC, Gileadi O, Jansma DB, Jennings EG, Kouyoumdjian F, Davidson AR, Young RA, Greenblatt J. An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. Molecular Cell. 4: 55-62. PMID 10445027 DOI: 10.1016/S1097-2765(00)80187-2  0.378
1999 Kimmelman J, Kaldis P, Hengartner CJ, Laff GM, Koh SS, Young RA, Solomon MJ. Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p. Molecular and Cellular Biology. 19: 4774-87. PMID 10373527 DOI: 10.1128/Mcb.19.7.4774  0.307
1999 Viljoen M, Volschenk H, Young RA, van Vuuren HJ. Transcriptional regulation of the Schizosaccharomyces pombe malic enzyme gene, mae2. The Journal of Biological Chemistry. 274: 9969-75. PMID 10187772 DOI: 10.1074/Jbc.274.15.9969  0.474
1999 Holstege FC, Young RA. Transcriptional regulation: contending with complexity. Proceedings of the National Academy of Sciences of the United States of America. 96: 2-4. PMID 9874759 DOI: 10.1073/Pnas.96.1.2  0.494
1999 Ren B, Young P, Young RA. A yeast genome expression monitoring database Nature Genetics. 23: 70-70. DOI: 10.1038/14389  0.484
1999 Jennings EG, Holstege FC, Wyrick JJ, Young RA. Combinatorial negative regulation of glucose-responsive genes in yeast Nature Genetics. 23: 53-53. DOI: 10.1038/14333  0.696
1999 Causton HC, Lee TI, Holstege FC, Jennings E, Young RA. Functional redundancy of two transcriptional coactivator complexes Nature Genetics. 23: 36-37. DOI: 10.1038/14278  0.36
1999 Young RA. Dissecting transcriptional circuitry and mechanisms in yeast Nature Genetics. 23: 14-14. DOI: 10.1038/14226  0.414
1998 Holstege FC, Jennings EG, Wyrick JJ, Lee TI, Hengartner CJ, Green MR, Golub TR, Lander ES, Young RA. Dissecting the regulatory circuitry of a eukaryotic genome. Cell. 95: 717-28. PMID 9845373 DOI: 10.1016/S0092-8674(00)81641-4  0.754
1998 Apone LM, Virbasius CA, Holstege FC, Wang J, Young RA, Green MR. Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. Molecular Cell. 2: 653-61. PMID 9844637 DOI: 10.1016/S1097-2765(00)80163-X  0.497
1998 Parvin JD, Young RA. Regulatory targets in the RNA polymerase II holoenzyme. Current Opinion in Genetics & Development. 8: 565-70. PMID 9794828 DOI: 10.1016/S0959-437X(98)80012-9  0.404
1998 Hengartner CJ, Myer VE, Liao SM, Wilson CJ, Koh SS, Young RA. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Molecular Cell. 2: 43-53. PMID 9702190 DOI: 10.1016/S1097-2765(00)80112-4  0.381
1998 Lee TI, Wyrick JJ, Koh SS, Jennings EG, Gadbois EL, Young RA. Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Molecular and Cellular Biology. 18: 4455-62. PMID 9671455 DOI: 10.1128/Mcb.18.8.4455  0.738
1998 Koh SS, Ansari AZ, Ptashne M, Young RA. An activator target in the RNA polymerase II holoenzyme. Molecular Cell. 1: 895-904. PMID 9660972 DOI: 10.1016/S1097-2765(00)80088-X  0.621
1998 Lee TI, Young RA. Regulation of gene expression by TBP-associated proteins. Genes & Development. 12: 1398-408. PMID 9585500 DOI: 10.1101/Gad.12.10.1398  0.524
1997 Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Molecular and Cellular Biology. 17: 6029-39. PMID 9315662 DOI: 10.1128/Mcb.17.10.6029  0.362
1997 Nau GJ, Guilfoile P, Chupp GL, Berman JS, Kim SJ, Kornfeld H, Young RA. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 6414-9. PMID 9177232 DOI: 10.1073/Pnas.94.12.6414  0.365
1997 Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. BRCA1 is a component of the RNA polymerase II holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 94: 5605-10. PMID 9159119 DOI: 10.1073/Pnas.94.11.5605  0.418
1997 Gadbois EL, Chao DM, Reese JC, Green MR, Young RA. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 3145-50. PMID 9096360 DOI: 10.1073/Pnas.94.7.3145  0.435
1997 Volschenk H, Viljoen M, Grobler J, Petzold B, Bauer F, Subden RE, Young RA, Lonvaud A, Denayrolles M, van Vuuren HJ. Engineering pathways for malate degradation in Saccharomyces cerevisiae. Nature Biotechnology. 15: 253-7. PMID 9062925 DOI: 10.1038/nbt0397-253  0.306
1996 Koleske AJ, Chao DM, Young RA. Purification of yeast RNA polymerase II holoenzymes. Methods in Enzymology. 273: 176-84. PMID 8791611 DOI: 10.1016/S0076-6879(96)73018-5  0.65
1996 Chao DM, Young RA. Activation without a vital ingredient. Nature. 383: 119-20. PMID 8774874 DOI: 10.1038/383119a0  0.421
1996 Rubin DM, Coux O, Wefes I, Hengartner C, Young RA, Goldberg AL, Finley D. Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome. Nature. 379: 655-7. PMID 8628401 DOI: 10.1038/379655a0  0.382
1996 Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Nature. 380: 82-5. PMID 8598913 DOI: 10.1038/380082a0  0.415
1996 Wilson CJ, Chao DM, Imbalzano AN, Schnitzler GR, Kingston RE, Young RA. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell. 84: 235-44. PMID 8565069 DOI: 10.1016/S0092-8674(00)80978-2  0.425
1995 Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature. 374: 280-2. PMID 7885450 DOI: 10.1038/374280A0  0.391
1995 Liao SM, Zhang J, Jeffery DA, Koleske AJ, Thompson CM, Chao DM, Viljoen M, van Vuuren HJ, Young RA. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature. 374: 193-6. PMID 7877695 DOI: 10.1038/374193a0  0.645
1995 Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao SM, Koleske AJ, Okamura S, Young RA. Association of an activator with an RNA polymerase II holoenzyme. Genes & Development. 9: 897-910. PMID 7774808 DOI: 10.1101/Gad.9.8.897  0.662
1995 Thompson CM, Young RA. General requirement for RNA polymerase II holoenzymes in vivo. Proceedings of the National Academy of Sciences of the United States of America. 92: 4587-90. PMID 7753848 DOI: 10.1073/Pnas.92.10.4587  0.369
1995 Koleske AJ, Young RA. The RNA polymerase II holoenzyme and its implications for gene regulation. Trends in Biochemical Sciences. 20: 113-6. PMID 7709429 DOI: 10.1016/S0968-0004(00)88977-X  0.666
1994 Koleske AJ, Young RA. An RNA polymerase II holoenzyme responsive to activators. Nature. 368: 466-9. PMID 8133894 DOI: 10.1038/368466a0  0.652
1993 Woychik NA, Young RA. RNA polymerase II subunit RPB10 is essential for yeast cell viability. The Journal of Biological Chemistry. 268: 12230. PMID 8505344  0.645
1993 McKune K, Richards KL, Edwards AM, Young RA, Woychik NA. RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability. Yeast (Chichester, England). 9: 295-9. PMID 8488730 DOI: 10.1002/Yea.320090309  0.698
1993 Choder M, Young RA. A portion of RNA polymerase II molecules has a component essential for stress responses and stress survival. Molecular and Cellular Biology. 13: 6984-91. PMID 8413288 DOI: 10.1128/Mcb.13.11.6984  0.349
1993 Thompson CM, Koleske AJ, Chao DM, Young RA. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell. 73: 1361-75. PMID 8324825 DOI: 10.1016/0092-8674(93)90362-T  0.647
1993 Aldovini A, Husson RN, Young RA. The uraA locus and homologous recombination in Mycobacterium bovis BCG. Journal of Bacteriology. 175: 7282-9. PMID 8226675 DOI: 10.1128/Jb.175.22.7282-7289.1993  0.35
1992 Bowen AR, Chen-Wu JL, Momany M, Young R, Szaniszlo PJ, Robbins PW. Classification of fungal chitin synthases. Proceedings of the National Academy of Sciences of the United States of America. 89: 519-23. PMID 1731323 DOI: 10.1073/Pnas.89.2.519  0.3
1992 Koleske AJ, Buratowski S, Nonet M, Young RA. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Cell. 69: 883-94. PMID 1591782 DOI: 10.1016/0092-8674(92)90298-Q  0.696
1992 Woychik NA, Young RA. Genes encoding transcription factor IIIA and the RNA polymerase common subunit RPB6 are divergently transcribed in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 89: 3999-4003. PMID 1570325 DOI: 10.1073/Pnas.89.9.3999  0.725
1992 Ferm MT, Söderström K, Jindal S, Grönberg A, Ivanyi J, Young R, Kiessling R. Induction of human hsp60 expression in monocytic cell lines International Immunology. 4: 305-311. PMID 1567788 DOI: 10.1093/Intimm/4.3.305  0.3
1992 Jindal S, Young RA. Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins. Journal of Virology. 66: 5357-62. PMID 1501279 DOI: 10.1128/Jvi.66.9.5357-5362.1992  0.303
1991 Hekmatpanah DS, Young RA. Mutations in a conserved region of RNA polymerase II influence the accuracy of mRNA start site selection. Molecular and Cellular Biology. 11: 5781-91. PMID 1922077 DOI: 10.1128/MCB.11.11.5781  0.35
1991 Young RA, Davis RW. Gene isolation with lambda gt11 system. Methods in Enzymology. 194: 230-8. PMID 1826035 DOI: 10.1016/0076-6879(91)94018-8  0.52
1991 Liao SM, Taylor ICA, Kingston RE, Young RA. RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro Genes and Development. 5: 2431-2440. PMID 1752437 DOI: 10.1101/Gad.5.12B.2431  0.42
1991 Woychik N, Lane W, Young R. Yeast RNA polymerase II subunit RPB9 is essential for growth at temperature extremes. Journal of Biological Chemistry. 266: 19053-19055. DOI: 10.1016/s0021-9258(18)55171-1  0.618
1990 Kolodziej P, Young RA. RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatus. Molecular and Cellular Biology. 9: 5387-94. PMID 2685562 DOI: 10.1128/MCB.9.12.5387  0.359
1990 Scafe C, Martin C, Nonet M, Podos S, Okamura S, Young RA. Conditional mutations occur predominantly in highly conserved residues of RNA polymerase II subunits Molecular and Cellular Biology. 10: 1270-1275. PMID 2406567 DOI: 10.1128/Mcb.10.3.1270  0.311
1990 Scafe C, Nonet M, Young RA. RNA polymerase II mutants defective in transcription of a subset of genes Molecular and Cellular Biology. 10: 1010-1016. PMID 2406558 DOI: 10.1128/Mcb.10.3.1010  0.416
1990 Scafe C, Chao D, Lopes J, Hirsch JP, Henry S, Young RA. RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals. Nature. 347: 491-4. PMID 2215664 DOI: 10.1038/347491A0  0.391
1990 Woychik NA, Liao SM, Kolodziej PA, Young RA. Subunits shared by eukaryotic nuclear RNA polymerases. Genes & Development. 4: 313-23. PMID 2186966 DOI: 10.1101/Gad.4.3.313  0.7
1990 Kolodziej PA, Woychik N, Liao SM, Young RA. RNA polymerase II subunit composition, stoichiometry, and phosphorylation. Molecular and Cellular Biology. 10: 1915-20. PMID 2183013 DOI: 10.1128/Mcb.10.5.1915  0.669
1990 Husson RN, James BE, Young RA. Gene replacement and expression of foreign DNA in mycobacteria. Journal of Bacteriology. 172: 519-24. PMID 2153655 DOI: 10.1128/JB.172.2.519-524.1990  0.329
1990 Aldovini A, Young RA. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. Journal of Virology. 64: 1920-1926. PMID 2109098 DOI: 10.1128/Jvi.64.5.1920-1926.1990  0.302
1990 Woychik NA, Young RA. RNA polymerase II: subunit structure and function. Trends in Biochemical Sciences. 15: 347-51. PMID 1700503 DOI: 10.1016/0968-0004(90)90074-L  0.7
1989 Woychik NA, Young RA. RNA polymerase II subunit RPB4 is essential for high- and low-temperature yeast cell growth. Molecular and Cellular Biology. 9: 2854-9. PMID 2674672 DOI: 10.1128/Mcb.9.7.2854  0.679
1989 Martin C, Young RA. KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth. Molecular and Cellular Biology. 9: 2341-9. PMID 2668732 DOI: 10.1128/MCB.9.6.2341  0.317
1987 Sweetser D, Nonet M, Young RA. Prokaryotic and eukaryotic RNA polymerases have homologous core subunits Proceedings of the National Academy of Sciences of the United States of America. 84: 1192-1196. PMID 3547406 DOI: 10.1073/Pnas.84.5.1192  0.351
1987 Nonet M, Sweetser D, Young RA. Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II Cell. 50: 909-915. PMID 3304659 DOI: 10.1016/0092-8674(87)90517-4  0.335
1987 Nonet M, Scafe C, Sexton J, Young R. Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis Molecular and Cellular Biology. 7: 1602-1611. PMID 3299050 DOI: 10.1128/Mcb.7.5.1602  0.304
1987 Snyder M, Elledge S, Sweetser D, Young RA, Davis RW. Lambda gt 11: gene isolation with antibody probes and other applications. Methods in Enzymology. 154: 107-28. PMID 2448583 DOI: 10.1016/0076-6879(87)54073-3  0.684
1986 Wei R, Wilkinson H, Pfeifer K, Schneider C, Young R, Guarente L. Two or more copies of Drosophila heat shock consensus sequence serve to activate transcription in yeast. Nucleic Acids Research. 14: 8183-8. PMID 3095794 DOI: 10.1093/Nar/14.20.8183  0.302
1986 Riva M, Memet S, Micouin JY, Huet J, Treich I, Dassa J, Young R, Buhler JM, Sentenac A, Fromageot P. Isolation of structural genes for yeast RNA polymerases by immunological screening. Proceedings of the National Academy of Sciences of the United States of America. 83: 1554-8. PMID 2937059 DOI: 10.1073/Pnas.83.6.1554  0.374
1986 Faust DM, Renkawitz-Pohl R, Falkenburg D, Gasch A, Bialojan S, Young RA, Bautz EK. Cloning and identification of the gene coding for the 140-kd subunit of Drosophila RNA polymerase II The Embo Journal. 5: 741-746. DOI: 10.1002/J.1460-2075.1986.Tb04276.X  0.401
1985 Young RA, Mehra V, Sweetser D, Buchanan T, Clark-Curtiss J, Davis RW, Bloom BR. Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae. Nature. 316: 450-2. PMID 3894979 DOI: 10.1038/316450A0  0.472
1985 Young RA, Bloom BR, Grosskinsky CM, Ivanyi J, Thomas D, Davis RW. Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. Proceedings of the National Academy of Sciences of the United States of America. 82: 2583-7. PMID 2581251 DOI: 10.1073/Pnas.82.9.2583  0.46
1983 Young RA, Davis RW. Yeast RNA polymerase II genes: isolation with antibody probes. Science (New York, N.Y.). 222: 778-82. PMID 6356359 DOI: 10.1126/Science.6356359  0.528
1983 Young RA, Davis RW. Efficient isolation of genes by using antibody probes. Proceedings of the National Academy of Sciences of the United States of America. 80: 1194-8. PMID 6219389 DOI: 10.1073/Pnas.80.5.1194  0.506
1981 Tosi M, Young RA, Hagenbuechle O, Schibler U. Multiple polyadenylation sites in a mouse α-amylase gene Nucleic Acids Research. 9: 2313-2323. PMID 6166922 DOI: 10.1093/Nar/9.10.2313  0.366
1980 Bram RJ, Young RA, Steitz JA. The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli. Cell. 19: 393-401. PMID 6153577 DOI: 10.1016/0092-8674(80)90513-9  0.549
1980 Young RA, Bram RJ, Steitz JA. rRNA and tRNA Processing Signals in the rRNA Operons of Escherichia coli Cold Spring Harbor Monograph Archive. 99-106. DOI: 10.1101/087969129.9B.99  0.571
1979 Reed RR, Young RA, Steitz JA, Grindley ND, Guyer MS. Transposition of the Escherichia coli insertion element gamma generates a five-base-pair repeat. Proceedings of the National Academy of Sciences of the United States of America. 76: 4882-6. PMID 388421 DOI: 10.1073/Pnas.76.10.4882  0.743
1979 Young RA, Macklis R, Steitz JA. Sequence of the 16 S-23 s spacer region in two ribosomal RNA operons of Escherichia coli. The Journal of Biological Chemistry. 254: 3264-71. PMID 372188  0.501
1979 Young RA, Steitz JA. Tandem promoters direct E. coli ribosomal RNA synthesis. Cell. 17: 225-34. PMID 110460 DOI: 10.1016/0092-8674(79)90310-6  0.557
1978 Young RA, Steitz JA. Complementary sequences 1700 nucleotides apart form a ribonuclease III cleavage site in Escherichia coli ribosomal precursor RNA. Proceedings of the National Academy of Sciences of the United States of America. 75: 3593-7. PMID 358189 DOI: 10.1073/Pnas.75.8.3593  0.556
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