Richard A. Young - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
gene control
Website:
https://biology.mit.edu/people/richard_young

241 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Fulciniti M, Lin CY, Samur MK, Lopez MA, Singh I, Lawlor MA, Szalat RE, Ott CJ, Avet-Loiseau H, Anderson KC, Young RA, Bradner JE, Munshi NC. Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma. Cell Reports. 25: 3693-3705.e6. PMID 30590042 DOI: 10.1016/j.celrep.2018.12.016  0.32
2018 Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, ... ... Young RA, et al. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell. PMID 30449618 DOI: 10.1016/j.cell.2018.10.042  0.4
2018 Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. PMID 30209401 DOI: 10.1038/s41586-018-0487-2  0.52
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature Genetics. PMID 30127528 DOI: 10.1038/s41588-018-0191-z  0.4
2018 Mansour MR, He S, Li Z, Lobbardi R, Abraham BJ, Hug C, Rahman S, Leon TE, Kuang YY, Zimmerman MW, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, ... ... Young RA, et al. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of Experimental Medicine. PMID 29941549 DOI: 10.1084/jem.20170484  0.4
2018 Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, ... ... Young RA, et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science (New York, N.Y.). PMID 29930091 DOI: 10.1126/science.aar3958  0.4
2018 Harmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, ... ... Young RA, et al. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications. 9: 16215. PMID 29676392 DOI: 10.1038/ncomms16215  0.4
2018 Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, ... ... Young RA, et al. Cross-cohort analysis identifies a TEAD4 ↔ MYCN positive-feedback loop as the core regulatory element of high-risk neuroblastoma. Cancer Discovery. PMID 29510988 DOI: 10.1158/2159-8290.CD-16-0861  0.4
2018 Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. PMID 29456084 DOI: 10.1016/j.cell.2018.01.012  0.64
2018 Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. BET bromodomain proteins regulate enhancer function during adipogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29444854 DOI: 10.1073/pnas.1711155115  0.32
2018 Eliades P, Abraham BJ, Ji Z, Miller DM, Christensen CL, Kwiatkowski N, Kumar R, Njauw CN, Taylor M, Miao B, Zhang T, Wong KK, Gray NS, Young RA, Tsao H. High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma. The Journal of Investigative Dermatology. PMID 29408204 DOI: 10.1016/j.jid.2017.09.056  0.4
2018 Iniguez AB, Stolte B, Wang EJ, Conway AS, Alexe G, Dharia NV, Kwiatkowski N, Zhang T, Abraham BJ, Mora J, Kalev P, Leggett A, Chowdhury D, Benes CH, Young RA, et al. EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. Cancer Cell. PMID 29358035 DOI: 10.1016/j.ccell.2017.12.009  0.4
2017 Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT. c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification. Cancer Discovery. PMID 29284669 DOI: 10.1158/2159-8290.CD-17-0993  0.4
2017 Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature Chemical Biology. PMID 29251720 DOI: 10.1038/nchembio.2538  0.32
2017 Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, ... Young RA, et al. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Cell. 171: 1573-1588.e28. PMID 29224777 DOI: 10.1016/j.cell.2017.11.008  0.64
2017 Rusan M, Li K, Li Y, Christensen CL, Abraham BJ, Kwiatkowski N, Buczkowski KA, Bockorny B, Chen T, Li S, Rhee K, Zhang H, Chen W, Terai H, Tavares T, ... ... Young RA, et al. Suppression of adaptive responses to targeted cancer therapy by transcriptional repression. Cancer Discovery. PMID 29054992 DOI: 10.1158/2159-8290.CD-17-0461  0.4
2017 Kalan S, Amat R, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Reports. 21: 467-481. PMID 29020632 DOI: 10.1016/j.celrep.2017.09.056  0.4
2017 Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, ... ... Young RA, et al. TOX regulates growth, DNA repair, and genomic instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discovery. PMID 28974511 DOI: 10.1158/2159-8290.CD-17-0267  0.4
2017 Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Science Translational Medicine. 9. PMID 28637928 DOI: 10.1126/scitranslmed.aai9118  0.4
2017 Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, ... ... Young RA, et al. Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes. Nature Communications. 8: 15797. PMID 28569765 DOI: 10.1038/ncomms15797  0.4
2017 Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, Ho P, Gip P, Swigut T, Sherwood RI, Clarke MF, ... ... Young RA, et al. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nature Communications. 8: 14802. PMID 28378740 DOI: 10.1038/ncomms14802  0.4
2017 Rahman S, Magnussen M, León TE, Farah N, Li Z, Abraham BJ, Alapi KZ, Mitchell RJ, Naughton T, Fielding AK, Pizzey A, Bustraan S, Allen C, Popa T, Pike-Overzet K, ... ... Young RA, et al. Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood. PMID 28270453 DOI: 10.1182/blood-2016-09-742148  0.4
2017 Harmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, ... ... Young RA, et al. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications. 8: 14433. PMID 28195122 DOI: 10.1038/ncomms14433  0.4
2017 Bradner JE, Hnisz D, Young RA. Transcriptional Addiction in Cancer. Cell. 168: 629-643. PMID 28187285 DOI: 10.1016/j.cell.2016.12.013  0.32
2017 Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, ... ... Young RA, et al. Small genomic insertions form enhancers that misregulate oncogenes. Nature Communications. 8: 14385. PMID 28181482 DOI: 10.1038/ncomms14385  0.4
2016 Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, Shu J, Dadon D, Young RA, Jaenisch R. Editing DNA Methylation in the Mammalian Genome. Cell. 167: 233-247.e17. PMID 27662091 DOI: 10.1016/j.cell.2016.08.056  0.52
2016 Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, ... ... Young RA, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nature Chemical Biology. PMID 27571479 DOI: 10.1038/nchembio.2166  0.52
2016 Clark VE, Harmancı AS, Bai H, Youngblood MW, Lee TI, Baranoski JF, Ercan-Sencicek AG, Abraham BJ, Weintraub AS, Hnisz D, Simon M, Krischek B, Erson-Omay EZ, Henegariu O, Carrión-Grant G, ... ... Young RA, et al. Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nature Genetics. PMID 27548314 DOI: 10.1038/ng.3651  0.4
2016 Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & Development. PMID 27492367 DOI: 10.1101/gad.282756.116  0.92
2016 Soldner F, Stelzer Y, Shivalila CS, Abraham BJ, Latourelle JC, Barrasa MI, Goldmann J, Myers RH, Young RA, Jaenisch R. Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature. PMID 27096366 DOI: 10.1038/nature17939  0.92
2016 Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, ... ... Young RA, et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science (New York, N.Y.). PMID 26940867 DOI: 10.1126/science.aad9024  0.92
2016 Saint-André V, Federation AJ, Lin CY, Abraham BJ, Reddy J, Lee TI, Bradner JE, Young RA. Models of human core transcriptional regulatory circuitries. Genome Research. PMID 26843070 DOI: 10.1101/gr.197590.115  0.92
2016 Heyn H, Vidal E, Ferreira HJ, Vizoso M, Sayols S, Gomez A, Moran S, Boque-Sastre R, Guil S, Martinez-Cardus A, Lin CY, Royo R, Sanchez-Mut JV, Martinez R, Gut M, ... ... Young RA, et al. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer. Genome Biology. 17: 11. PMID 26813288 DOI: 10.1186/s13059-016-0879-2  0.92
2016 Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Jin Huh S, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, ... ... Young RA, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. PMID 26735014 DOI: 10.1038/nature16508  0.32
2015 Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA. 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell. PMID 26686465 DOI: 10.1016/j.stem.2015.11.007  0.52
2015 D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA. A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity. Stem Cell Reports. PMID 26603904 DOI: 10.1016/j.stemcr.2015.09.016  0.52
2015 Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, ... ... Young RA, et al. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature. PMID 26560027 DOI: 10.1038/nature15540  0.52
2015 Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Transcription factor trapping by RNA in gene regulatory elements. Science (New York, N.Y.). PMID 26516199 DOI: 10.1126/science.aad3346  0.52
2015 Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 163: 174-186. PMID 26406377 DOI: 10.1016/j.cell.2015.08.063  0.52
2015 Hnisz D, Schuijers J, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA. Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Molecular Cell. 58: 362-70. PMID 25801169 DOI: 10.1016/j.molcel.2015.02.014  0.52
2015 Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proceedings of the National Academy of Sciences of the United States of America. 112: 3841-6. PMID 25755260 DOI: 10.1073/pnas.1502971112  0.92
2015 Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes & Development. 29: 483-8. PMID 25737277 DOI: 10.1101/gad.254151.114  0.92
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell. 15: 524-526. PMID 28903030 DOI: 10.1016/j.stem.2014.09.003  0.64
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell. 15: 523. PMID 28903029 DOI: 10.1016/j.stem.2014.08.002  0.64
2014 Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel JB, Cavanaugh JD, ... ... Young RA, et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell. 26: 909-22. PMID 25490451 DOI: 10.1016/j.ccell.2014.10.019  0.52
2014 Cassady JP, D'Alessio AC, Sarkar S, Dani VS, Fan ZP, Ganz K, Roessler R, Sur M, Young RA, Jaenisch R. Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells. Stem Cell Reports. 3: 948-56. PMID 25454632 DOI: 10.1016/j.stemcr.2014.10.001  0.52
2014 Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, Zhang T, Hatheway CM, Abraham BJ, Sharma B, Yeung C, Altabef A, Perez-Atayde A, Wong KK, Yuan GC, Gray NS, Young RA, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell. 159: 1126-39. PMID 25416950 DOI: 10.1016/j.cell.2014.10.024  0.52
2014 Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science (New York, N.Y.). 346: 1373-7. PMID 25394790 DOI: 10.1126/science.1259037  0.52
2014 Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schuijers J, Lee TI, Zhao K, Young RA. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 159: 374-87. PMID 25303531 DOI: 10.1016/j.cell.2014.09.030  0.52
2014 Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham BJ, Porubsky D, Kulenkampff E, Faddah DA, Shi L, Gao Q, Sarkar S, ... ... Young RA, et al. The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell. 15: 295-309. PMID 25192464 DOI: 10.1016/j.stem.2014.07.003  0.52
2014 Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D'Alessio A, ... ... Young RA, et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 15: 471-87. PMID 25090446 DOI: 10.1016/j.stem.2014.07.002  0.52
2014 Choi YJ, Saez B, Anders L, Hydbring P, Stefano J, Bacon NA, Cook C, Kalaszczynska I, Signoretti S, Young RA, Scadden DT, Sicinski P. D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Developmental Cell. 30: 255-67. PMID 25087893 DOI: 10.1016/j.devcel.2014.06.015  0.52
2014 Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, ... ... Young RA, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 511: 616-20. PMID 25043025 DOI: 10.1038/nature13393  0.52
2014 Dowen JM, Young RA. SMC complexes link gene expression and genome architecture. Current Opinion in Genetics & Development. 25: 131-7. PMID 24794701 DOI: 10.1016/j.gde.2013.11.009  0.52
2014 Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, ... ... Young RA, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 40: 477-89. PMID 24745332 DOI: 10.1016/j.immuni.2014.04.004  0.52
2014 Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, ... ... Young RA, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 6: 313-24. PMID 24440720 DOI: 10.1016/j.celrep.2013.12.032  0.52
2014 Rahl PB, Young RA. MYC and transcription elongation. Cold Spring Harbor Perspectives in Medicine. 4: a020990. PMID 24384817 DOI: 10.1101/cshperspect.a020990  0.52
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Genome-wide localization of small molecules. Nature Biotechnology. 32: 92-6. PMID 24336317 DOI: 10.1038/nbt.2776  0.52
2014 Chapuy B, McKeown MR, Lin CY, Monti S, Roemer MGM, Qi J, Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E, Kung AL, Rodig SJ, Young RA, Shipp MA, et al. Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma Cancer Cell. 25: 545-546. DOI: 10.1016/j.ccr.2014.03.029  0.92
2013 Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 1: 371-8. PMID 24286025 DOI: 10.1016/j.stemcr.2013.09.002  0.52
2013 Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Young RA, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/gad.232710.113  0.52
2013 Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 155: 934-47. PMID 24119843 DOI: 10.1016/j.cell.2013.09.053  0.92
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, ... Young RA, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/j.stem.2013.09.001  0.52
2013 Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 16061-6. PMID 24043772 DOI: 10.1073/pnas.1315204110  0.52
2013 Mazzoni EO, Mahony S, Peljto M, Patel T, Thornton SR, McCuine S, Reeder C, Boyer LA, Young RA, Gifford DK, Wichterle H. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nature Neuroscience. 16: 1191-8. PMID 23955559 DOI: 10.1038/nn.3490  0.52
2013 Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. The Journal of Experimental Medicine. 210: 1545-57. PMID 23857984 DOI: 10.1084/jem.20122516  0.52
2013 Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, D'Alessio AC, Young RA, Weinberg RA. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell. 154: 61-74. PMID 23827675 DOI: 10.1016/j.cell.2013.06.005  0.52
2013 Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA. Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes & Development. 27: 941-54. PMID 23630078 DOI: 10.1101/gad.215376.113  0.52
2013 Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/j.cell.2013.03.036  0.92
2013 Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 153: 307-19. PMID 23582322 DOI: 10.1016/j.cell.2013.03.035  0.92
2013 Lee TI, Young RA. Transcriptional regulation and its misregulation in disease. Cell. 152: 1237-51. PMID 23498934 DOI: 10.1016/j.cell.2013.02.014  0.92
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/pnas.1221904110  0.92
2012 Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA. Revisiting global gene expression analysis. Cell. 151: 476-82. PMID 23101621 DOI: 10.1016/j.cell.2012.10.012  0.92
2012 Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 151: 56-67. PMID 23021215 DOI: 10.1016/j.cell.2012.08.026  0.92
2012 Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 22: 209-21. PMID 22897851 DOI: 10.1016/j.ccr.2012.06.007  0.92
2012 Welstead GG, Creyghton MP, Bilodeau S, Cheng AW, Markoulaki S, Young RA, Jaenisch R. X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 109: 13004-9. PMID 22826230 DOI: 10.1073/pnas.1210787109  0.52
2012 Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/j.ygeno.2012.07.006  0.92
2012 Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 11: 319-32. PMID 22770845 DOI: 10.1016/j.stem.2012.06.002  0.92
2012 Guenther MG, Young RA. Grounded: transcriptional pausing in naive mESCs. Cell Stem Cell. 10: 484-5. PMID 22560069 DOI: 10.1016/j.stem.2012.04.016  0.92
2012 Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Developmental Cell. 22: 625-38. PMID 22421047 DOI: 10.1016/j.devcel.2012.01.003  0.92
2012 Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. 482: 221-5. PMID 22297846 DOI: 10.1038/nature10805  0.92
2012 Cheng B, Li T, Rahl PB, Adamson TE, Loudas NB, Guo J, Varzavand K, Cooper JJ, Hu X, Gnatt A, Young RA, Price DH. Functional association of Gdown1 with RNA polymerase II poised on human genes. Molecular Cell. 45: 38-50. PMID 22244331 DOI: 10.1016/j.molcel.2011.10.022  0.92
2011 Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H. Embryonic stem cell-based mapping of developmental transcriptional programs. Nature Methods. 8: 1056-8. PMID 22081127 DOI: 10.1038/nmeth.1775  0.92
2011 Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, ... ... Young RA, et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 147: 577-89. PMID 22036566 DOI: 10.1016/j.cell.2011.09.044  0.92
2011 Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/j.cell.2011.08.050  0.92
2011 Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, ... ... Young RA, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/j.cell.2011.08.017  0.92
2011 Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. Plos One. 6: e22416. PMID 21886766 DOI: 10.1371/journal.pone.0022416  0.92
2011 Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell. 9: 219-32. PMID 21885018 DOI: 10.1016/j.stem.2011.07.015  0.92
2011 Wong P, Hattangadi SM, Cheng AW, Frampton GM, Young RA, Lodish HF. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood. 118: e128-38. PMID 21860024 DOI: 10.1182/blood-2011-03-341404  0.92
2011 Wang J, Kumar RM, Biggs VJ, Lee H, Chen Y, Kagey MH, Young RA, Abate-Shen C. The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. Developmental Cell. 21: 575-88. PMID 21852201 DOI: 10.1016/j.devcel.2011.07.003  0.92
2011 White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, ... ... Young RA, et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471: 518-22. PMID 21430780 DOI: 10.1038/nature09882  0.92
2011 Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, ... ... Young RA, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471: 513-7. PMID 21430779 DOI: 10.1038/nature09806  0.92
2011 Young RA. Control of the embryonic stem cell state. Cell. 144: 940-54. PMID 21414485 DOI: 10.1016/j.cell.2011.01.032  0.92
2011 Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, ... ... Young RA, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 144: 296-309. PMID 21241896 DOI: 10.1016/j.cell.2011.01.004  0.92
2011 Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK. Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Genome Biology. 12: R2. PMID 21232103 DOI: 10.1186/gb-2011-12-1-r2  0.92
2011 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, Van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture (Nature (2010) 467 (430-435)) Nature. 472: 247. DOI: 10.1038/nature09930  0.92
2010 Newman JJ, Young RA. Connecting transcriptional control to chromosome structure and human disease. Cold Spring Harbor Symposia On Quantitative Biology. 75: 227-35. PMID 21209391 DOI: 10.1101/sqb.2010.75.016  0.92
2010 Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proceedings of the National Academy of Sciences of the United States of America. 107: 21931-6. PMID 21106759 DOI: 10.1073/pnas.1016071107  0.92
2010 Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 67: 781-96. PMID 20826310 DOI: 10.1016/j.neuron.2010.08.008  0.92
2010 Heard E, Tishkoff S, Todd JA, Vidal M, Wagner GP, Wang J, Weigel D, Young R. Ten years of genetics and genomics: what have we achieved and where are we heading? Nature Reviews. Genetics. 11: 723-33. PMID 20820184 DOI: 10.1038/nrg2878  0.92
2010 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 467: 430-5. PMID 20720539 DOI: 10.1038/nature09380  0.92
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/j.stem.2010.06.015  0.92
2010 Guenther MG, Young RA. Transcription. Repressive transcription. Science (New York, N.Y.). 329: 150-1. PMID 20616255 DOI: 10.1126/science.1193995  0.92
2010 Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes & Development. 24: 1479-84. PMID 20581084 DOI: 10.1101/gad.1935210  0.92
2010 Kanhere A, Viiri K, Araújo CC, Rasaiyaah J, Bouwman RD, Whyte WA, Pereira CF, Brookes E, Walker K, Bell GW, Pombo A, Fisher AG, Young RA, Jenner RG. Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Molecular Cell. 38: 675-88. PMID 20542000 DOI: 10.1016/j.molcel.2010.03.019  0.92
2010 Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 141: 872-83. PMID 20471072 DOI: 10.1016/j.cell.2010.04.010  0.92
2010 Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA. c-Myc regulates transcriptional pause release. Cell. 141: 432-45. PMID 20434984 DOI: 10.1016/j.cell.2010.03.030  0.92
2010 Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 463: 374-8. PMID 20090754 DOI: 10.1038/nature08684  0.92
2009 Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA. SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes & Development. 23: 2484-9. PMID 19884255 DOI: 10.1101/gad.1837309  0.92
2009 Juan AH, Kumar RM, Marx JG, Young RA, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Molecular Cell. 36: 61-74. PMID 19818710 DOI: 10.1016/j.molcel.2009.08.008  0.92
2009 Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proceedings of the National Academy of Sciences of the United States of America. 106: 17876-81. PMID 19805038 DOI: 10.1073/pnas.0909357106  0.92
2008 Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes & Development. 22: 3403-8. PMID 19141473 DOI: 10.1101/gad.1741408  0.92
2008 Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Divergent transcription from active promoters. Science (New York, N.Y.). 322: 1849-51. PMID 19056940 DOI: 10.1126/science.1162253  0.92
2008 Cole MF, Young RA. Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harbor Symposia On Quantitative Biology. 73: 183-93. PMID 19022761 DOI: 10.1101/sqb.2008.73.027  0.92
2008 Creyghton MP, Markoulaki S, Levine SS, Hanna J, Lodato MA, Sha K, Young RA, Jaenisch R, Boyer LA. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell. 135: 649-61. PMID 18992931 DOI: 10.1016/j.cell.2008.09.056  0.92
2008 Lopez-Bigas N, Kisiel TA, Dewaal DC, Holmes KB, Volkert TL, Gupta S, Love J, Murray HL, Young RA, Benevolenskaya EV. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Molecular Cell. 31: 520-30. PMID 18722178 DOI: 10.1016/j.molcel.2008.08.004  0.92
2008 Mathur D, Danford TW, Boyer LA, Young RA, Gifford DK, Jaenisch R. Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET. Genome Biology. 9: R126. PMID 18700969 DOI: 10.1186/gb-2008-9-8-r126  0.92
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, ... ... Young RA, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/j.cell.2008.07.020  0.92
2008 Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell. 3: 132-5. PMID 18682236 DOI: 10.1016/j.stem.2008.06.019  0.92
2008 Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes & Development. 22: 746-55. PMID 18347094 DOI: 10.1101/gad.1642408  0.92
2008 Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 132: 567-82. PMID 18295576 DOI: 10.1016/j.cell.2008.01.015  0.92
2007 Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nature Genetics. 39: 1512-6. PMID 17994019 DOI: 10.1038/ng.2007.26  0.92
2007 Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. Plos One. 2: e1061. PMID 17957245 DOI: 10.1371/journal.pone.0001061  0.92
2007 Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell. 130: 77-88. PMID 17632057 DOI: 10.1016/j.cell.2007.05.042  0.92
2007 Zeitlinger J, Zinzen RP, Stark A, Kellis M, Zhang H, Young RA, Levine M. Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes & Development. 21: 385-90. PMID 17322397 DOI: 10.1101/gad.1509607  0.92
2007 Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 445: 931-5. PMID 17237765 DOI: 10.1038/nature05478  0.92
2006 Lee TI, Johnstone SE, Young RA. Chromatin immunoprecipitation and microarray-based analysis of protein location. Nature Protocols. 1: 729-48. PMID 17406303 DOI: 10.1038/nprot.2006.98  0.92
2006 Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proceedings of the National Academy of Sciences of the United States of America. 103: 18261-6. PMID 17114293 DOI: 10.1073/pnas.0606108103  0.92
2006 Qi Y, Rolfe A, MacIsaac KD, Gerber GK, Pokholok D, Zeitlinger J, Danford T, Dowell RD, Fraenkel E, Jaakkola TS, Young RA, Gifford DK. High-resolution computational models of genome binding events. Nature Biotechnology. 24: 963-70. PMID 16900145 DOI: 10.1038/nbt1233  0.92
2006 Wardle FC, Odom DT, Bell GW, Yuan B, Danford TW, Wiellette EL, Herbolsheimer E, Sive HL, Young RA, Smith JC. Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biology. 7: R71. PMID 16889661 DOI: 10.1186/gb-2006-7-8-R71  0.92
2006 Pokholok DK, Zeitlinger J, Hannett NM, Reynolds DB, Young RA. Activated signal transduction kinases frequently occupy target genes. Science (New York, N.Y.). 313: 533-6. PMID 16873666 DOI: 10.1126/science.1127677  0.92
2006 Odom DT, Dowell RD, Jacobsen ES, Nekludova L, Rolfe PA, Danford TW, Gifford DK, Fraenkel E, Bell GI, Young RA. Core transcriptional regulatory circuitry in human hepatocytes. Molecular Systems Biology. 2: 2006.0017. PMID 16738562 DOI: 10.1038/msb4100059  0.92
2006 Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, ... ... Young RA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 125: 301-13. PMID 16630818 DOI: 10.1016/j.cell.2006.02.043  0.92
2006 Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 441: 349-53. PMID 16625203 DOI: 10.1038/nature04733  0.92
2006 Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood. 108: 986-92. PMID 16621969 DOI: 10.1182/blood-2005-08-3482  0.92
2006 Schreiber J, Jenner RG, Murray HL, Gerber GK, Gifford DK, Young RA. Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 103: 5899-904. PMID 16595631 DOI: 10.1073/pnas.0510996103  0.92
2006 Keshet I, Schlesinger Y, Farkash S, Rand E, Hecht M, Segal E, Pikarski E, Young RA, Niveleau A, Cedar H, Simon I. Evidence for an instructive mechanism of de novo methylation in cancer cells. Nature Genetics. 38: 149-53. PMID 16444255 DOI: 10.1038/ng1719  0.92
2006 Cao Y, Kumar RM, Penn BH, Berkes CA, Kooperberg C, Boyer LA, Young RA, Tapscott SJ. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. The Embo Journal. 25: 502-11. PMID 16437161 DOI: 10.1038/sj.emboj.7600958  0.92
2006 Macisaac KD, Gordon DB, Nekludova L, Odom DT, Schreiber J, Gifford DK, Young RA, Fraenkel E. A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data. Bioinformatics (Oxford, England). 22: 423-9. PMID 16332710 DOI: 10.1093/bioinformatics/bti815  0.92
2005 Kiburz BM, Reynolds DB, Megee PC, Marston AL, Lee BH, Lee TI, Levine SS, Young RA, Amon A. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes & Development. 19: 3017-30. PMID 16357219 DOI: 10.1101/gad.1373005  0.92
2005 Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122: 947-56. PMID 16153702 DOI: 10.1016/j.cell.2005.08.020  0.92
2005 Balciunaite E, Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Molecular and Cellular Biology. 25: 8166-78. PMID 16135806 DOI: 10.1128/MCB.25.18.8166-8178.2005  0.92
2005 Pokholok DK, Harbison CT, Levine S, Cole M, Hannett NM, Lee TI, Bell GW, Walker K, Rolfe PA, Herbolsheimer E, Zeitlinger J, Lewitter F, Gifford DK, Young RA. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell. 122: 517-27. PMID 16122420 DOI: 10.1016/j.cell.2005.06.026  0.92
2005 Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Molecular Cell. 18: 623-35. PMID 15949438 DOI: 10.1016/j.molcel.2005.05.012  0.92
2005 Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA. Global and Hox-specific roles for the MLL1 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 8603-8. PMID 15941828 DOI: 10.1073/pnas.0503072102  0.92
2005 Jenner RG, Young RA. Insights into host responses against pathogens from transcriptional profiling. Nature Reviews. Microbiology. 3: 281-94. PMID 15806094 DOI: 10.1038/nrmicro1126  0.92
2004 Mukherjee S, Berger MF, Jona G, Wang XS, Muzzey D, Snyder M, Young RA, Bulyk ML. Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nature Genetics. 36: 1331-9. PMID 15543148 DOI: 10.1038/ng1473  0.92
2004 Cam H, Balciunaite E, Blais A, Spektor A, Scarpulla RC, Young R, Kluger Y, Dynlacht BD. A common set of gene regulatory networks links metabolism and growth inhibition. Molecular Cell. 16: 399-411. PMID 15525513 DOI: 10.1016/j.molcel.2004.09.037  0.92
2004 Robert F, Pokholok DK, Hannett NM, Rinaldi NJ, Chandy M, Rolfe A, Workman JL, Gifford DK, Young RA. Global position and recruitment of HATs and HDACs in the yeast genome. Molecular Cell. 16: 199-209. PMID 15494307 DOI: 10.1016/j.molcel.2004.09.021  0.92
2004 Harbison CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J, Jennings EG, Zeitlinger J, Pokholok DK, Kellis M, Rolfe PA, ... ... Young RA, et al. Transcriptional regulatory code of a eukaryotic genome. Nature. 431: 99-104. PMID 15343339 DOI: 10.1038/nature02800  0.92
2004 Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science (New York, N.Y.). 303: 1378-81. PMID 14988562 DOI: 10.1126/science.1089769  0.92
2004 Palliser D, Huang Q, Hacohen N, Lamontagne SP, Guillen E, Young RA, Eisen HN. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. Journal of Immunology (Baltimore, Md. : 1950). 172: 2885-93. PMID 14978090  0.92
2003 Bar-Joseph Z, Gerber GK, Lee TI, Rinaldi NJ, Yoo JY, Robert F, Gordon DB, Fraenkel E, Jaakkola TS, Young RA, Gifford DK. Computational discovery of gene modules and regulatory networks. Nature Biotechnology. 21: 1337-42. PMID 14555958 DOI: 10.1038/nbt890  0.92
2003 Dror RO, Murnick JG, Rinaldi NJ, Marinescu VD, Rifkin RM, Young RA. Bayesian estimation of transcript levels using a general model of array measurement noise. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 10: 433-52. PMID 12935337 DOI: 10.1089/10665270360688110  0.92
2003 Shen WC, Bhaumik SR, Causton HC, Simon I, Zhu X, Jennings EG, Wang TH, Young RA, Green MR. Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. The Embo Journal. 22: 3395-402. PMID 12840001 DOI: 10.1093/emboj/cdg336  0.92
2003 Nau GJ, Schlesinger A, Richmond JF, Young RA. Cumulative Toll-like receptor activation in human macrophages treated with whole bacteria. Journal of Immunology (Baltimore, Md. : 1950). 170: 5203-9. PMID 12734368  0.92
2003 Zeitlinger J, Simon I, Harbison CT, Hannett NM, Volkert TL, Fink GR, Young RA. Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell. 113: 395-404. PMID 12732146 DOI: 10.1016/S0092-8674(03)00301-5  0.92
2003 Ng HH, Robert F, Young RA, Struhl K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Molecular Cell. 11: 709-19. PMID 12667453 DOI: 10.1016/S1097-2765(03)00092-3  0.92
2003 Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nature Medicine. 9: 191-7. PMID 12539042 DOI: 10.1038/nm822  0.92
2002 Ansari AZ, Koh SS, Zaman Z, Bongards C, Lehming N, Young RA, Ptashne M. Transcriptional activating regions target a cyclin-dependent kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 14706-9. PMID 12417740 DOI: 10.1073/pnas.232573899  0.92
2002 Lee TI, Rinaldi NJ, Robert F, Odom DT, Bar-Joseph Z, Gerber GK, Hannett NM, Harbison CT, Thompson CM, Simon I, Zeitlinger J, Jennings EG, Murray HL, Gordon DB, Ren B, ... ... Young RA, et al. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (New York, N.Y.). 298: 799-804. PMID 12399584 DOI: 10.1126/science.1075090  0.92
2002 Stanojevic D, Young RA. A highly potent artificial transcription factor. Biochemistry. 41: 7209-16. PMID 12044151 DOI: 10.1021/bi015906b  0.92
2002 Pokholok DK, Hannett NM, Young RA. Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Molecular Cell. 9: 799-809. PMID 11983171  0.32
2002 Ng HH, Robert F, Young RA, Struhl K. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes & Development. 16: 806-19. PMID 11937489 DOI: 10.1101/gad.978902  0.92
2002 Damelin M, Simon I, Moy TI, Wilson B, Komili S, Tempst P, Roth FP, Young RA, Cairns BR, Silver PA. The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Molecular Cell. 9: 563-73. PMID 11931764 DOI: 10.1016/S1097-2765(02)00475-6  0.92
2002 Hartemink AJ, Gifford DK, Jaakkola TS, Young RA. Combining location and expression data for principled discovery of genetic regulatory network models. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 437-49. PMID 11928497  0.92
2002 Wyrick JJ, Young RA. Deciphering gene expression regulatory networks. Current Opinion in Genetics & Development. 12: 130-6. PMID 11893484 DOI: 10.1016/S0959-437X(02)00277-0  0.92
2002 Nau GJ, Richmond JF, Schlesinger A, Jennings EG, Lander ES, Young RA. Human macrophage activation programs induced by bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 99: 1503-8. PMID 11805289 DOI: 10.1073/pnas.022649799  0.44
2002 Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes & Development. 16: 245-56. PMID 11799067 DOI: 10.1101/gad.949802  0.92
2001 Young RA, Lesperance RM. The Gaussian derivative model for spatial-temporal vision: II. Cortical data. Spatial Vision. 14: 321-89. PMID 11817741 DOI: 10.1163/156856801753253591  0.08
2001 Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP, Aparicio OM. Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (New York, N.Y.). 294: 2357-60. PMID 11743203 DOI: 10.1126/science.1066101  0.92
2001 Virbasius CM, Holstege FC, Young RA, Green MR. Promoter-specific activation defects by a novel yeast TBP mutant compromised for TFIIB interaction. Current Biology : Cb. 11: 1794-8. PMID 11719223  0.52
2001 Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science (New York, N.Y.). 294: 870-5. PMID 11679675 DOI: 10.1126/science.294.5543.870  0.92
2001 Simon I, Barnett J, Hannett N, Harbison CT, Rinaldi NJ, Volkert TL, Wyrick JJ, Zeitlinger J, Gifford DK, Jaakkola TS, Young RA. Serial regulation of transcriptional regulators in the yeast cell cycle. Cell. 106: 697-708. PMID 11572776 DOI: 10.1016/S0092-8674(01)00494-9  0.92
2001 Wilson CJ, Guglielmo C, Moua ND, Tudor M, Grosveld G, Young RA, Murray PJ. Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. Analytical Biochemistry. 296: 270-8. PMID 11554723 DOI: 10.1006/abio.2001.5304  0.48
2001 Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS, Carr SA, Deshaies RJ. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes & Development. 15: 1078-92. PMID 11331604 DOI: 10.1101/gad.867501  0.92
2001 Geisberg JV, Holstege FC, Young RA, Struhl K. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Molecular and Cellular Biology. 21: 2736-42. PMID 11283253 DOI: 10.1128/MCB.21.8.2736-2742.2001  0.92
2001 Hartemink AJ, Gifford DK, Jaakkola TS, Young RA. Using graphical models and genomic expression data to statistically validate models of genetic regulatory networks. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 422-33. PMID 11262961  0.92
2001 Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA. Remodeling of yeast genome expression in response to environmental changes. Molecular Biology of the Cell. 12: 323-37. PMID 11179418  0.92
2000 Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA. Genome-wide location and function of DNA binding proteins. Science (New York, N.Y.). 290: 2306-9. PMID 11125145 DOI: 10.1126/science.290.5500.2306  0.92
2000 Lee TI, Young RA. Transcription of eukaryotic protein-coding genes. Annual Review of Genetics. 34: 77-137. PMID 11092823 DOI: 10.1146/annurev.genet.34.1.77  0.32
2000 Young RA. Biomedical discovery with DNA arrays. Cell. 102: 9-15. PMID 10929708  0.92
2000 Lee TI, Causton HC, Holstege FC, Shen WC, Hannett N, Jennings EG, Winston F, Green MR, Young RA. Redundant roles for the TFIID and SAGA complexes in global transcription. Nature. 405: 701-4. PMID 10864329 DOI: 10.1038/35015104  0.92
2000 Robertson LS, Causton HC, Young RA, Fink GR. The yeast A kinases differentially regulate iron uptake and respiratory function. Proceedings of the National Academy of Sciences of the United States of America. 97: 5984-8. PMID 10811893 DOI: 10.1073/pnas.100113397  0.92
2000 Cho BK, Palliser D, Guillen E, Wisniewski J, Young RA, Chen J, Eisen HN. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity. 12: 263-72. PMID 10755613  0.92
2000 Huang Q, Richmond JF, Suzue K, Eisen HN, Young RA. In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independent. The Journal of Experimental Medicine. 191: 403-8. PMID 10637285 DOI: 10.1084/jem.191.2.403  0.92
1999 Wyrick JJ, Holstege FC, Jennings EG, Causton HC, Shore D, Grunstein M, Lander ES, Young RA. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature. 402: 418-21. PMID 10586882 DOI: 10.1038/46567  0.92
1999 Tudor M, Murray PJ, Onufryk C, Jaenisch R, Young RA. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes & Development. 13: 2365-8. PMID 10500093  0.64
1999 Kobor MS, Archambault J, Lester W, Holstege FC, Gileadi O, Jansma DB, Jennings EG, Kouyoumdjian F, Davidson AR, Young RA, Greenblatt J. An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. Molecular Cell. 4: 55-62. PMID 10445027 DOI: 10.1016/S1097-2765(00)80187-2  0.92
1999 Kimmelman J, Kaldis P, Hengartner CJ, Laff GM, Koh SS, Young RA, Solomon MJ. Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p. Molecular and Cellular Biology. 19: 4774-87. PMID 10373527  0.92
1999 Murray PJ, Young RA. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infection and Immunity. 67: 3087-95. PMID 10338525  0.48
1999 Jennings EG, Young RA. Genome expression on the World Wide Web. Trends in Genetics : Tig. 15: 202-4. PMID 10322488  0.44
1999 Holstege FC, Young RA. Transcriptional regulation: contending with complexity. Proceedings of the National Academy of Sciences of the United States of America. 96: 2-4. PMID 9874759  0.52
1998 Murray PJ, Young RA. Secretion of mammalian proteins from mycobacteria. Methods in Molecular Biology (Clifton, N.J.). 101: 275-84. PMID 9921486 DOI: 10.1385/0-89603-471-2:275  0.48
1998 Holstege FC, Jennings EG, Wyrick JJ, Lee TI, Hengartner CJ, Green MR, Golub TR, Lander ES, Young RA. Dissecting the regulatory circuitry of a eukaryotic genome. Cell. 95: 717-28. PMID 9845373  0.92
1998 Apone LM, Virbasius CA, Holstege FC, Wang J, Young RA, Green MR. Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. Molecular Cell. 2: 653-61. PMID 9844637  0.52
1998 Lee TI, Wyrick JJ, Koh SS, Jennings EG, Gadbois EL, Young RA. Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Molecular and Cellular Biology. 18: 4455-62. PMID 9671455  0.92
1998 Koh SS, Ansari AZ, Ptashne M, Young RA. An activator target in the RNA polymerase II holoenzyme. Molecular Cell. 1: 895-904. PMID 9660972  0.92
1998 Lee TI, Young RA. Regulation of gene expression by TBP-associated proteins. Genes & Development. 12: 1398-408. PMID 9585500  0.32
1998 Murray PJ, Young RA, Daley GQ. Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. Blood. 91: 2914-24. PMID 9531602  0.48
1997 Suzue K, Zhou X, Eisen HN, Young RA. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proceedings of the National Academy of Sciences of the United States of America. 94: 13146-51. PMID 9371814 DOI: 10.1073/pnas.94.24.13146  0.92
1997 Qin J, Fenyö D, Zhao Y, Hall WW, Chao DM, Wilson CJ, Young RA, Chait BT. A strategy for rapid, high-confidence protein identification. Analytical Chemistry. 69: 3995-4001. PMID 9322436  0.56
1997 Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Molecular and Cellular Biology. 17: 6029-39. PMID 9315662  0.4
1997 Nau GJ, Guilfoile P, Chupp GL, Berman JS, Kim SJ, Kornfeld H, Young RA. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 6414-9. PMID 9177232 DOI: 10.1073/pnas.94.12.6414  0.92
1997 Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. BRCA1 is a component of the RNA polymerase II holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 94: 5605-10. PMID 9159119  0.56
1997 Gadbois EL, Chao DM, Reese JC, Green MR, Young RA. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 3145-50. PMID 9096360 DOI: 10.1073/pnas.94.7.3145  0.92
1997 Murray PJ, Wang L, Onufryk C, Tepper RI, Young RA. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. Journal of Immunology (Baltimore, Md. : 1950). 158: 315-21. PMID 8977205  0.48
1996 Koleske AJ, Chao DM, Young RA. Purification of yeast RNA polymerase II holoenzymes. Methods in Enzymology. 273: 176-84. PMID 8791611  0.56
1996 Chao DM, Young RA. Activation without a vital ingredient. Nature. 383: 119-20. PMID 8774874 DOI: 10.1038/383119a0  0.56
1996 Rubin DM, Coux O, Wefes I, Hengartner C, Young RA, Goldberg AL, Finley D. Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome. Nature. 379: 655-7. PMID 8628401 DOI: 10.1038/379655a0  0.92
1996 Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Nature. 380: 82-5. PMID 8598913 DOI: 10.1038/380082a0  0.56
1996 Murray PJ, Aldovini A, Young RA. Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines. Proceedings of the National Academy of Sciences of the United States of America. 93: 934-9. PMID 8570663  0.48
1996 Wilson CJ, Chao DM, Imbalzano AN, Schnitzler GR, Kingston RE, Young RA. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell. 84: 235-44. PMID 8565069 DOI: 10.1016/S0092-8674(00)80978-2  0.92
1995 Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature. 374: 280-2. PMID 7885450 DOI: 10.1038/374280a0  0.92
1995 Liao SM, Zhang J, Jeffery DA, Koleske AJ, Thompson CM, Chao DM, Viljoen M, van Vuuren HJ, Young RA. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature. 374: 193-6. PMID 7877695 DOI: 10.1038/374193a0  0.92
1995 Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao SM, Koleske AJ, Okamura S, Young RA. Association of an activator with an RNA polymerase II holoenzyme. Genes & Development. 9: 897-910. PMID 7774808  0.92
1995 Thompson CM, Young RA. General requirement for RNA polymerase II holoenzymes in vivo. Proceedings of the National Academy of Sciences of the United States of America. 92: 4587-90. PMID 7753848  0.56
1995 Koleske AJ, Young RA. The RNA polymerase II holoenzyme and its implications for gene regulation. Trends in Biochemical Sciences. 20: 113-6. PMID 7709429 DOI: 10.1016/S0968-0004(00)88977-X  0.92
1995 Murray PJ, Watowich SS, Lodish HF, Young RA, Hilton DJ. Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions. Analytical Biochemistry. 229: 170-9. PMID 7485969 DOI: 10.1006/abio.1995.1399  0.48
1994 O'Donnell MA, Aldovini A, Duda RB, Yang H, Szilvasi A, Young RA, DeWolf WC. Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infection and Immunity. 62: 2508-14. PMID 8188376  0.92
1994 Koleske AJ, Young RA. An RNA polymerase II holoenzyme responsive to activators. Nature. 368: 466-9. PMID 8133894 DOI: 10.1038/368466a0  0.92
1994 Jindal S, Burke E, Bettencourt B, Khandekar S, Young RA, Dwyer DS. Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation. Immunology Letters. 39: 127-35. PMID 7912221 DOI: 10.1016/0165-2478(94)90097-3  0.92
1994 Tsomides TJ, Aldovini A, Johnson RP, Walker BD, Young RA, Eisen HN. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. The Journal of Experimental Medicine. 180: 1283-93. PMID 7523570  0.92
1993 Woychik NA, McKune K, Lane WS, Young RA. Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. Gene Expression. 3: 77-82. PMID 8508029  0.96
1993 Woychik NA, Young RA. RNA polymerase II subunit RPB10 is essential for yeast cell viability. The Journal of Biological Chemistry. 268: 12230. PMID 8505344  0.96
1993 McKune K, Richards KL, Edwards AM, Young RA, Woychik NA. RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability. Yeast (Chichester, England). 9: 295-9. PMID 8488730 DOI: 10.1002/yea.320090309  0.96
1993 Thompson CM, Koleske AJ, Chao DM, Young RA. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell. 73: 1361-75. PMID 8324825 DOI: 10.1016/0092-8674(93)90362-T  0.52
1992 Murray PJ, Young RA. Stress and immunological recognition in host-pathogen interactions. Journal of Bacteriology. 174: 4193-6. PMID 1624412  0.48
1992 Koleske AJ, Buratowski S, Nonet M, Young RA. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Cell. 69: 883-94. PMID 1591782 DOI: 10.1016/0092-8674(92)90298-Q  0.92
1992 Jindal S, Young RA. Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins. Journal of Virology. 66: 5357-62. PMID 1501279  0.92
1991 Young RA, Davis RW. Gene isolation with lambda gt11 system. Methods in Enzymology. 194: 230-8. PMID 1826035 DOI: 10.1016/0076-6879(91)94018-8  0.92
1987 Snyder M, Elledge S, Sweetser D, Young RA, Davis RW. Lambda gt 11: gene isolation with antibody probes and other applications. Methods in Enzymology. 154: 107-28. PMID 2448583  0.88
1985 Young RA, Mehra V, Sweetser D, Buchanan T, Clark-Curtiss J, Davis RW, Bloom BR. Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae. Nature. 316: 450-2. PMID 3894979  0.88
1985 Young RA, Bloom BR, Grosskinsky CM, Ivanyi J, Thomas D, Davis RW. Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. Proceedings of the National Academy of Sciences of the United States of America. 82: 2583-7. PMID 2581251  0.88
1983 Young RA, Davis RW. Yeast RNA polymerase II genes: isolation with antibody probes. Science (New York, N.Y.). 222: 778-82. PMID 6356359  0.92
1983 Young RA, Davis RW. Efficient isolation of genes by using antibody probes. Proceedings of the National Academy of Sciences of the United States of America. 80: 1194-8. PMID 6219389  0.88
1980 Bram RJ, Young RA, Steitz JA. The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli. Cell. 19: 393-401. PMID 6153577  1
1979 Reed RR, Young RA, Steitz JA, Grindley ND, Guyer MS. Transposition of the Escherichia coli insertion element gamma generates a five-base-pair repeat. Proceedings of the National Academy of Sciences of the United States of America. 76: 4882-6. PMID 388421 DOI: 10.1073/pnas.76.10.4882  0.92
1979 Young RA, Macklis R, Steitz JA. Sequence of the 16 S-23 s spacer region in two ribosomal RNA operons of Escherichia coli. The Journal of Biological Chemistry. 254: 3264-71. PMID 372188  1
1979 Young RA, Steitz JA. Tandem promoters direct E. coli ribosomal RNA synthesis. Cell. 17: 225-34. PMID 110460  1
1978 Young RA, Steitz JA. Complementary sequences 1700 nucleotides apart form a ribonuclease III cleavage site in Escherichia coli ribosomal precursor RNA. Proceedings of the National Academy of Sciences of the United States of America. 75: 3593-7. PMID 358189  1
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