Binu Tharakan - Publications

Affiliations: 
2012-2019 Surgery Texas A&M University College of Medicine and & Baylor Scott and White Research Institute 
 2019- Surgery Morehouse School of Medicine, Atlanta, GA, United States 
Area:
Blood-brain barrier, microvascular permeability, traumatic brain injury

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Malek AJ, Robinson BD, Hitt AR, Shaver CN, Tharakan B, Isbell CL. Doxycycline improves traumatic brain injury outcomes in a murine survival model. The Journal of Trauma and Acute Care Surgery. PMID 32467458 DOI: 10.1097/TA.0000000000002801  0.48
2020 Robinson BD, Tharakan B, Lomas A, Wiggins-Dohlvik K, Alluri H, Shaji CA, Jupiter D, Isbell CL. Exploring blood-brain barrier hyperpermeability and potential biomarkers in traumatic brain injury. Proceedings (Baylor University. Medical Center). 33: 199-204. PMID 32313461 DOI: 10.1080/08998280.2020.1727706  0.92
2019 Anasooya Shaji C, Robinson BD, Yeager A, Beeram MR, Davis ML, Isbell CL, Huang JH, Tharakan B. The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells. Scientific Reports. 9: 133. PMID 30644421 DOI: 10.1038/s41598-018-36769-3  0.76
2018 Robinson BD, Isbell CL, Shaji CA, Kurek S, Regner JL, Tharakan B. QUETIAPINE PROTECTS THE BLOOD-BRAIN BARRIER IN TRAUMATIC BRAIN INJURY. The Journal of Trauma and Acute Care Surgery. PMID 29985239 DOI: 10.1097/TA.0000000000002011  0.76
2018 Robinson BD, Shaji CA, Lomas A, Tharakan B. Measurement of Microvascular Endothelial Barrier Dysfunction and Hyperpermeability In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1717: 237-242. PMID 29468597 DOI: 10.1007/978-1-4939-7526-6_19  0.76
2018 Wiggins-Dohlvik K, Tharakan B. A Rat Burn Injury Model for Studying Changes in Microvascular Permeability. Methods in Molecular Biology (Clifton, N.J.). 1717: 93-100. PMID 29468586 DOI: 10.1007/978-1-4939-7526-6_8  0.92
2018 Alluri H, Shaji CA, Davis ML, Tharakan B. A Mouse Controlled Cortical Impact Model of Traumatic Brain Injury for Studying Blood-Brain Barrier Dysfunctions. Methods in Molecular Biology (Clifton, N.J.). 1717: 37-52. PMID 29468582 DOI: 10.1007/978-1-4939-7526-6_4  0.76
2017 Liu Y, Wang J, Li J, Wang R, Tharakan B, Zhang SL, Tong CW, Peng X. Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia. Clinical and Translational Medicine. 6: 40. PMID 29101495 DOI: 10.1186/s40169-017-0171-4  0.32
2016 Alluri H, Grimsley M, Anasooya Shaji C, Varghese KP, Zhang SL, Peddaboina C, Robinson B, Beeram MR, Huang JH, Tharakan B. Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. The Journal of Biological Chemistry. PMID 27875293 DOI: 10.1074/jbc.M116.735365  0.76
2016 Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Patel S, Liu Y, Peng X, Beeram MR, Davis ML, Huang JH, Tharakan B. Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition. Plos One. 11: e0154427. PMID 27152411 DOI: 10.1371/journal.pone.0154427  1
2016 Dayawansa S, Zhang J, Shih CH, Tharakan B, Huang JH. Functional, electrophysiological recoveries of rats with sciatic nerve lesions following transplantation of elongated DRG cells. Neurological Research. 1-6. PMID 27078705 DOI: 10.1080/01616412.2015.1105586  1
2015 Wiggins-Dohlvik K, Stagg HW, Han MS, Alluri H, Oakley RP, Shaji CA, Davis ML, Tharakan B. Doxycycline Attenuates Lipopolysaccharide-Induced Microvascular Endothelial Cell Derangements. Shock (Augusta, Ga.). PMID 26717103 DOI: 10.1097/SHK.0000000000000556  1
2015 Wiggins-Dohlvik K, Oakley RP, Han MS, Stagg HW, Alluri H, Shaji CA, Davis ML, Tharakan B. Tissue inhibitor of metalloproteinase-2 inhibits burn-induced derangements and hyperpermeability in microvascular endothelial cells. American Journal of Surgery. PMID 26601648 DOI: 10.1016/j.amjsurg.2015.08.016  1
2015 Sawant DA, Tharakan B, Hunter FA, Childs EW. Glycogen synthase kinase 3 inhibitor protects against microvascular hyperpermeability following hemorrhagic shock. The Journal of Trauma and Acute Care Surgery. 79: 609-16. PMID 26402535 DOI: 10.1097/TA.0000000000000807  1
2015 Alluri H, Anasooya Shaji C, Davis ML, Tharakan B. Oxygen-glucose deprivation and reoxygenation as an in vitro ischemia-reperfusion injury model for studying blood-brain barrier dysfunction. Journal of Visualized Experiments : Jove. e52699. PMID 25992584 DOI: 10.3791/52699  1
2015 Alluri H, Wiggins-Dohlvik K, Davis ML, Huang JH, Tharakan B. Blood-brain barrier dysfunction following traumatic brain injury. Metabolic Brain Disease. PMID 25624154 DOI: 10.1007/s11011-015-9651-7  1
2014 Sawant DA, Wilson RL, Tharakan B, Stagg HW, Hunter FA, Childs EW. Tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability: role of intrinsic apoptotic signaling. Journal of Physiology and Biochemistry. 70: 971-80. PMID 25392259 DOI: 10.1007/s13105-014-0366-8  1
2014 Wiggins-Dohlvik K, Merriman M, Shaji CA, Alluri H, Grimsley M, Davis ML, Smith RW, Tharakan B. Tumor necrosis factor-α disruption of brain endothelial cell barrier is mediated through matrix metalloproteinase-9. American Journal of Surgery. 208: 954-60; discussion 9. PMID 25312844 DOI: 10.1016/j.amjsurg.2014.08.014  1
2014 Sawant DA, Tharakan B, Hunter FA, Childs EW. The role of intrinsic apoptotic signaling in hemorrhagic shock-induced microvascular endothelial cell barrier dysfunction. Journal of Cardiovascular Translational Research. 7: 711-8. PMID 25277298 DOI: 10.1007/s12265-014-9589-x  1
2014 Wiggins-Dohlvik K, Han MS, Stagg HW, Alluri H, Shaji CA, Oakley RP, Davis ML, Tharakan B. Melatonin inhibits thermal injury-induced hyperpermeability in microvascular endothelial cells. The Journal of Trauma and Acute Care Surgery. 77: 899-905; discussion . PMID 25051382 DOI: 10.1097/TA.0000000000000346  1
2014 Oakley R, Tharakan B. Vascular hyperpermeability and aging. Aging and Disease. 5: 114-25. PMID 24729937 DOI: 10.14336/AD.2014.0500114  1
2014 Alluri H, Stagg HW, Wilson RL, Clayton RP, Sawant DA, Koneru M, Beeram MR, Davis ML, Tharakan B. Reactive oxygen species-caspase-3 relationship in mediating blood-brain barrier endothelial cell hyperpermeability following oxygen-glucose deprivation and reoxygenation. Microcirculation (New York, N.Y. : 1994). 21: 187-95. PMID 24372803 DOI: 10.1111/micc.12110  1
2014 Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC. The effects of inflammatory cytokines on lymphatic endothelial barrier function. Angiogenesis. 17: 395-406. PMID 24141404 DOI: 10.1007/s10456-013-9393-2  1
2013 Stagg HW, Whaley JG, Tharakan B, Hunter FA, Jupiter D, Little DC, Davis ML, Smythe WR, Childs EW. Doxycycline attenuates burn-induced microvascular hyperpermeability. The Journal of Trauma and Acute Care Surgery. 75: 1040-6; discussion 1. PMID 24256679 DOI: 10.1097/TA.0b013e3182aa9c79  1
2013 Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW. Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large. The Journal of Surgical Research. 184: 628-37. PMID 23731686 DOI: 10.1016/j.jss.2013.04.079  1
2013 Stagg HW, Bowen KA, Sawant DA, Rodriguez M, Tharakan B, Childs EW. Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through phosphatidylinositol 3-kinase pathway. American Journal of Surgery. 205: 419-25. PMID 23375756 DOI: 10.1016/j.amjsurg.2012.10.027  1
2013 Sawant DA, Tharakan B, Tobin RP, Reilly J, Hunter FA, Newell MK, Smythe WR, Childs EW. Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine. The Journal of Trauma and Acute Care Surgery. 74: 516-23. PMID 23354245 DOI: 10.1097/TA.0b013e31827a0620  1
2013 Sawant DA, Tharakan B, Tobin RP, Stagg HW, Hunter FA, Newell MK, Smythe WR, Childs EW. Inhibition of Fas-Fas ligand interaction attenuates microvascular hyperpermeability following hemorrhagic shock. Shock (Augusta, Ga.). 39: 161-7. PMID 23324886 DOI: 10.1097/SHK.0b013e31827bba73  1
2013 Driscoll MD, Robin BN, Horie M, Hubert ZT, Sampson HW, Jupiter DC, Tharakan B, Reeve RE. Marrow stimulation improves meniscal healing at early endpoints in a rabbit meniscal injury model. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 29: 113-21. PMID 23200846 DOI: 10.1016/j.arthro.2012.06.023  1
2012 Stahl D, Souder N, Probe R, Sampson W, Tharakan B, Ward R. The effects of hypothermia and L-arginine on skeletal muscle function in ischemia-reperfusion injury. Journal of Orthopaedic Trauma. 26: 579-84. PMID 22430525 DOI: 10.1097/BOT.0b013e31823dea55  1
2012 Tharakan B, Dhanasekaran M, Manyam BV. Differential effects of dopaminergic neurotoxins on DNA cleavage. Life Sciences. 91: 1-4. PMID 22213117 DOI: 10.1016/j.lfs.2011.12.003  1
2012 Tharakan B, Hellman J, Sawant DA, Tinsley JH, Parrish AR, Hunter FA, Smythe WR, Childs EW. β-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability. Shock (Augusta, Ga.). 37: 306-11. PMID 22089197 DOI: 10.1097/SHK.0b013e318240b564  1
2011 Sawant DA, Tharakan B, Hunter FA, Smythe WR, Childs EW. Role of β-catenin in regulating microvascular endothelial cell hyperpermeability. The Journal of Trauma. 70: 481-7; discussion 48. PMID 21307750 DOI: 10.1097/TA.0b013e31820b3ed7  1
2011 Sawant DA, Tharakan B, Adekanbi A, Hunter FA, Smythe WR, Childs EW. Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability. Microcirculation (New York, N.Y. : 1994). 18: 46-55. PMID 21166925 DOI: 10.1111/j.1549-8719.2010.00067.x  1
2011 Tharakan B, Chowdhury I, Bhat G. Fundamental mechanisms and implications of neuronal apoptosis Neuronal Cell Apoptosis. 143-165.  1
2010 Tharakan B, Hunter FA, Smythe WR, Childs EW. Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock. Clinical and Experimental Pharmacology & Physiology. 37: 939-44. PMID 20528978 DOI: 10.1111/j.1440-1681.2010.05414.x  1
2010 Childs EW, Tharakan B, Nurudeen S, Delmas TL, Hellman J, Christie T, Hunter FA, Smythe WR. Cyclosporine A--protection against microvascular hyperpermeability is calcineurin independent. American Journal of Surgery. 199: 542-8. PMID 20359571 DOI: 10.1016/j.amjsurg.2009.11.002  1
2010 Childs EW, Tharakan B, Hunter FA, Smythe WR. 17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling. Shock (Augusta, Ga.). 34: 229-35. PMID 20160663 DOI: 10.1097/SHK.0b013e3181d75b50  1
2010 Tharakan B, Whaley JG, Hunter FA, Smythe WR, Childs EW. (-)-Deprenyl inhibits vascular hyperpermeability after hemorrhagic shock. Shock (Augusta, Ga.). 33: 56-63. PMID 19373132 DOI: 10.1097/SHK.0b013e3181a7fb7c  1
2009 Whaley JG, Tharakan B, Smith B, Hunter FA, Childs EW. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. Journal of Burn Care & Research : Official Publication of the American Burn Association. 30: 1018-27. PMID 19826263 DOI: 10.1097/BCR.0b013e3181bfb825  1
2009 Tharakan B, Holder-Haynes JG, Hunter FA, Smythe WR, Childs EW. Cyclosporine A prevents vascular hyperpermeability after hemorrhagic shock by inhibiting apoptotic signaling. The Journal of Trauma. 66: 1033-9. PMID 19359911 DOI: 10.1097/TA.0b013e31816c905f  1
2009 Uddin MN, McLean LB, Hunter FA, Horvat D, Severson J, Tharakan B, Childs EW, Puschett JB. Vascular leak in a rat model of preeclampsia. American Journal of Nephrology. 30: 26-33. PMID 19194101 DOI: 10.1159/000193220  1
2009 Tharakan B, Corprew R, Hunter FA, Whaley JG, Smythe WR, Childs EW. 17beta-estradiol mediates protection against microvascular endothelial cell hyperpermeability. American Journal of Surgery. 197: 147-54. PMID 19185107 DOI: 10.1016/j.amjsurg.2008.10.003  1
2009 Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytotherapy Research : Ptr. 23: 14-9. PMID 19048607 DOI: 10.1002/ptr.2405  1
2008 Tharakan B, Hunter FA, Smythe WR, Childs EW. Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeability. Shock (Augusta, Ga.). 30: 571-7. PMID 18923301 DOI: 10.1097/SHK.0b013e31816a7308  1
2008 Chowdhury I, Tharakan B, Bhat GK. Caspases - an update. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 151: 10-27. PMID 18602321 DOI: 10.1016/j.cbpb.2008.05.010  1
2008 Childs EW, Tharakan B, Hunter FA, Isong M, Liggins ND. Mitochondrial complex III is involved in proapoptotic BAK-induced microvascular endothelial cell hyperpermeability. Shock (Augusta, Ga.). 29: 636-41. PMID 18414238 DOI: 10.1097/SHK.0b013e318157f524  1
2008 Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2285-95. PMID 18344375 DOI: 10.1152/ajpheart.01361.2007  1
2008 Tharakan B, Holder-Haynes JG, Hunter FA, Childs EW. Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling. American Journal of Surgery. 195: 174-8. PMID 18096126 DOI: 10.1016/j.amjsurg.2007.09.028  1
2008 Dhanasekaran M, Tharakan B, Manyam BV. Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity. Phytotherapy Research : Ptr. 22: 6-11. PMID 18064727 DOI: 10.1002/ptr.2109  1
2007 Tharakan B, Dhanasekaran M, Mize-Berge J, Manyam BV. Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage. Phytotherapy Research : Ptr. 21: 1124-6. PMID 17622977 DOI: 10.1002/ptr.2219  1
2007 Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytotherapy Research : Ptr. 21: 965-9. PMID 17604373 DOI: 10.1002/ptr.2195  1
2007 Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. American Journal of Physiology. Heart and Circulatory Physiology. 292: H3179-89. PMID 17307990 DOI: 10.1152/ajpheart.01337.2006  1
2006 Chowdhury I, Tharakan B, Bhat GK. Current concepts in apoptosis: the physiological suicide program revisited. Cellular & Molecular Biology Letters. 11: 506-25. PMID 16977376 DOI: 10.2478/s11658-006-0041-3  1
2006 Tharakan B, Dhanasekaran M, Brown-Borg HM, Manyam BV. Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. Phytotherapy Research : Ptr. 20: 165-8. PMID 16617470 DOI: 10.1002/ptr.1773  1
2006 Tharakan B, Manyam BV. Botanical therapies in chronic fatigue. Phytotherapy Research : Ptr. 20: 91-5. PMID 16444659 DOI: 10.1002/ptr.1794  1
2005 Tharakan B, Dhanasekaran M, Manyam BV. Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus zeylanicus. Phytotherapy Research : Ptr. 19: 669-73. PMID 16177968 DOI: 10.1002/ptr.1725  1
2005 Tharakan B, Manyam BV. Botanical therapies in sexual dysfunction. Phytotherapy Research : Ptr. 19: 457-63. PMID 16114077 DOI: 10.1002/ptr.1634  1
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