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Danielle A. Simmons - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
neuroinflammation, BDNF, Huntington's Disease
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30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Latif-Hernandez A, Yang T, Raymond-Butler R, Losada PM, Minhas P, White H, Tran KC, Liu H, Simmons DA, Langness V, Andreasson K, Wyss-Coray T, Longo FM. A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. Biorxiv : the Preprint Server For Biology. PMID 37781573 DOI: 10.1101/2023.09.18.558138  0.451
2023 Simmons DA, Belichenko NP, Longo FM. Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease. Journal of Huntington's Disease. PMID 37638447 DOI: 10.3233/JHD-230589  0.496
2021 Gonzalez S, McHugh TLM, Yang T, Syriani W, Massa SM, Longo FM, Simmons DA. Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage. Neurobiology of Disease. 105563. PMID 34838668 DOI: 10.1016/j.nbd.2021.105563  0.511
2021 Simmons DA, Mills BD, Butler Iii RR, Kuan J, McHugh TLM, Akers C, Zhou J, Syriani W, Grouban M, Zeineh M, Longo FM. Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 Ligand LM11A-31. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33786806 DOI: 10.1007/s13311-021-01023-8  0.443
2019 Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, et al. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31253467 DOI: 10.1016/J.Radonc.2019.06.006  0.458
2019 Boakye PA, Rancic V, Whitlock KH, Simmons D, Longo FM, Ballanyi K, Smith PA. Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1). Journal of Neurophysiology. PMID 30995156 DOI: 10.1152/Jn.00839.2018  0.499
2018 Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM. TSPO-PET Imaging Using [18F]PBR06 is a Potential Translatable Biomarker for Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31. Human Molecular Genetics. PMID 29860333 DOI: 10.1093/Hmg/Ddy202  0.482
2017 Simmons DA. Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease. Journal of Huntington's Disease. 6: 303-325. PMID 29254102 DOI: 10.3233/JHD-170275  0.364
2016 Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. 25: 4920-4938. PMID 28171570 DOI: 10.1093/Hmg/Ddw316  0.537
2016 Simmons DA, Longo FM, Massa SM. Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease. Cns & Neurological Disorders Drug Targets. PMID 27823570 DOI: 10.2174/1871527315666161107093047  0.525
2016 Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signaling and reduces Huntington's Disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. PMID 27638888 DOI: 10.1093/hmg/ddw316  0.483
2016 Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. PMID 27334657 DOI: 10.1016/J.Neuropharm.2016.06.015  0.54
2014 Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. Plos One. 9: e102136. PMID 25153701 DOI: 10.1371/journal.pone.0102136  0.517
2014 Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20: 659-63. PMID 24793238 DOI: 10.1038/Nm.3569  0.472
2013 Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18712-27. PMID 24285878 DOI: 10.1523/Jneurosci.1310-13.2013  0.563
2013 Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging. 34: 2052-63. PMID 23545424 DOI: 10.1016/J.Neurobiolaging.2013.02.015  0.532
2013 Longo F, Nguyen T, Simmons D, Yang T, Knowles J, Zhang H, Arancio O, Massa S, Longo F. S4-02-04: Targeting Alzheimer's disease-related mechanisms with p75 ligands Alzheimer's & Dementia. 9: P674-P674. DOI: 10.1016/J.Jalz.2013.04.323  0.468
2012 Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiology of Aging. 33: 708-19. PMID 20674095 DOI: 10.1016/J.Neurobiolaging.2010.06.008  0.444
2011 Simmons DA, Yahr P. Nitric oxidergic cells related to ejaculation in gerbil forebrain contain androgen receptor and respond to testosterone. The Journal of Comparative Neurology. 519: 900-15. PMID 21280043 DOI: 10.1002/cne.22557  0.652
2011 Simmons DA, Hoffman NW, Yahr P. A forebrain-retrorubral pathway involved in male sex behavior is GABAergic and activated with mating in gerbils. Neuroscience. 175: 162-8. PMID 21118711 DOI: 10.1016/j.neuroscience.2010.11.048  0.638
2011 Simmons DA, Yahr P. Distribution of catecholaminergic and peptidergic cells in the gerbil medial amygdala, caudal preoptic area and caudal bed nuclei of the stria terminalis with a focus on areas activated at ejaculation. Journal of Chemical Neuroanatomy. 41: 13-9. PMID 21087661 DOI: 10.1016/j.jchemneu.2010.10.005  0.635
2011 Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G. Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiology of Disease. 41: 436-44. PMID 20977939 DOI: 10.1016/J.Nbd.2010.10.015  0.472
2009 Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 4906-11. PMID 19264961 DOI: 10.1073/Pnas.0811228106  0.476
2007 Fedulov V, Rex CS, Simmons DA, Palmer L, Gall CM, Lynch G. Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8031-9. PMID 17652593 DOI: 10.1523/Jneurosci.2003-07.2007  0.485
2007 Simmons DA, Casale M, Alcon B, Pham N, Narayan N, Lynch G. Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease. Glia. 55: 1074-84. PMID 17551926 DOI: 10.1002/glia.20526  0.448
2007 Lynch G, Kramar EA, Rex CS, Jia Y, Chappas D, Gall CM, Simmons DA. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4424-34. PMID 17442827 DOI: 10.1523/Jneurosci.5113-06.2007  0.508
2003 Simmons DA, Yahr P. GABA and glutamate in mating-activated cells in the preoptic area and medial amygdala of male gerbils. The Journal of Comparative Neurology. 459: 290-300. PMID 12655511 DOI: 10.1002/cne.10605  0.64
2002 Simmons DA, Yahr P. Projections of the posterodorsal preoptic nucleus and the lateral part of the posterodorsal medial amygdala in male gerbils, with emphasis on cells activated with ejaculation. The Journal of Comparative Neurology. 444: 75-94. PMID 11835183 DOI: 10.1002/cne.10128  0.626
1998 Lonstein JS, Simmons DA, Stern JM. Functions of the caudal periaqueductal gray in lactating rats: kyphosis, lordosis, maternal aggression, and fearfulness. Behavioral Neuroscience. 112: 1502-18. PMID 9926832 DOI: 10.1037/0735-7044.112.6.1502  0.365
1998 Lonstein JS, Simmons DA, Swann JM, Stern JM. Forebrain expression of c-fos due to active maternal behaviour in lactating rats. Neuroscience. 82: 267-81. PMID 9483519 DOI: 10.1016/S0306-4522(97)00283-2  0.443
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